EphA2

Summary

Gene Symbol: EphA2
Description: EPH receptor A2
Alias: ARCC2, CTPA, CTPP1, CTRCT6, ECK, ephrin type-A receptor 2, epithelial cell receptor protein tyrosine kinase, soluble EPHA2 variant 1, tyrosine-protein kinase receptor ECK
Species: human

Top Publications

  1. ncbi Upregulation of EphA2 during in vivo and in vitro renal ischemia-reperfusion injury: role of Src kinases
    Cindy Baldwin
    Dept of Medicine, Division of Nephrology, McGill Univ, Lyman Duff Bldg Rm 228, 3775 Univ St, Montreal, Quebec, Canada
    Am J Physiol Renal Physiol 291:F960-71. 2006
  2. ncbi Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo
    Dana M Brantley
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, TN 37232, USA
    Oncogene 21:7011-26. 2002
  3. pmc EPHA2 polymorphisms and age-related cataract in India
    Periasamy Sundaresan
    Department of Genetics, Dr G Venkataswamy Eye Research Institute, Aravind Medical Research Foundation, Aravind Eye Hospital, Madurai, Tamil Nadu, India
    PLoS ONE 7:e33001. 2012
  4. doi Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism
    Wei Bin Fang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Sci 121:358-68. 2008
  5. pmc Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract
    Margaret A Cooper
    Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 105:16620-5. 2008
  6. pmc Autosomal recessive congenital cataract linked to EPHA2 in a consanguineous Pakistani family
    Haiba Kaul
    National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Mol Vis 16:511-7. 2010
  7. ncbi Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase
    A Pandey
    Department of Pathology University of Michigan Medical School, Ann Arbor 48109 0602, USA
    J Biol Chem 270:19201-4. 1995
  8. ncbi Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity
    A Pandey
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109 0602
    J Biol Chem 269:30154-7. 1994
  9. ncbi ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers
    E P Sulman
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Genomics 40:371-4. 1997
  10. ncbi Negative regulation of EphA2 receptor by Cbl
    You jie Wang
    First Department of Pathology, Hamamatsu University School of Medicine, 1 20 1, Handayama, 431 3192, Hamamatsu, Japan
    Biochem Biophys Res Commun 296:214-20. 2002

Research Grants

  1. Jack T Stapleton; Fiscal Year: 2016
  2. Michael J Mullan; Fiscal Year: 2014
  3. Copolymer hydrogel microspheres for analysis of kinase activity in cell lysates
    Sean P Palecek; Fiscal Year: 2010
  4. Bingcheng Wang; Fiscal Year: 2014
  5. An allosteric inhibitor of ZAP-70 as a novel therapeutic for autoimmune disease
    Arthur Weiss; Fiscal Year: 2010
  6. STRUCTURAL STUDY OF THE INSULIN RECEPTOR TYROSINE KINASE
    Stevan R Hubbard; Fiscal Year: 2010
  7. Carol B Post; Fiscal Year: 2016
  8. ARTHUR ROBERT SALOMON; Fiscal Year: 2014
  9. Src Family Kinases as Molecular Targets for HIV/Nef
    THOMAS EDWARD SMITHGALL; Fiscal Year: 2010
  10. Complexes of HIV-1 Nef with Src-family Kinases as Therapeutic Targets
    Lori A Emert Sedlak; Fiscal Year: 2010

Detail Information

Publications211 found, 100 shown here

  1. ncbi Upregulation of EphA2 during in vivo and in vitro renal ischemia-reperfusion injury: role of Src kinases
    Cindy Baldwin
    Dept of Medicine, Division of Nephrology, McGill Univ, Lyman Duff Bldg Rm 228, 3775 Univ St, Montreal, Quebec, Canada
    Am J Physiol Renal Physiol 291:F960-71. 2006
    ..We found that one receptor in particular, EphA2, was strongly upregulated in the kidney following IRI...
  2. ncbi Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo
    Dana M Brantley
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, TN 37232, USA
    Oncogene 21:7011-26. 2002
    ..Ephrin-A1 ligand was expressed in both tumor and endothelial cells, and EphA2 receptor was localized primarily in tumor-associated vascular endothelial cells...
  3. pmc EPHA2 polymorphisms and age-related cataract in India
    Periasamy Sundaresan
    Department of Genetics, Dr G Venkataswamy Eye Research Institute, Aravind Medical Research Foundation, Aravind Eye Hospital, Madurai, Tamil Nadu, India
    PLoS ONE 7:e33001. 2012
    We investigated whether previously reported single nucleotide polymorphisms (SNPs) of EPHA2 in European studies are associated with cataract in India.
  4. doi Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism
    Wei Bin Fang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Sci 121:358-68. 2008
    b>EPHA2 receptor tyrosine kinase is overexpressed in several human cancer types and promotes malignancy. However, the mechanisms by which EPHA2 promotes tumor progression are not completely understood...
  5. pmc Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract
    Margaret A Cooper
    Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 105:16620-5. 2008
    ..We further demonstrate that ephrin-A5 interacts with the EphA2 receptor to regulate the adherens junction complex by enhancing recruitment of beta-catenin to N-cadherin...
  6. pmc Autosomal recessive congenital cataract linked to EPHA2 in a consanguineous Pakistani family
    Haiba Kaul
    National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
    Mol Vis 16:511-7. 2010
    ..To investigate the genetic basis of autosomal recessive congenital cataracts in a consanguineous Pakistani family...
  7. ncbi Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase
    A Pandey
    Department of Pathology University of Michigan Medical School, Ann Arbor 48109 0602, USA
    J Biol Chem 270:19201-4. 1995
    ..Using a yeast two-hybrid screen to identify molecules that interact with the cytoplasmic domain of Eck, it was previously shown that activated Eck RPTK bound to and stimulated phosphatidylinositol 3-kinase (Pandey, A...
  8. ncbi Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity
    A Pandey
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109 0602
    J Biol Chem 269:30154-7. 1994
    The Eph/Eck subfamily of receptor protein tyrosine kinases is currently the largest subfamily of receptor protein tyrosine kinases with a dozen members (Van der Geer, P., Hunter, T., and Lindberg, R. A. (1994) Annu. Rev. Cell Biol...
  9. ncbi ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers
    E P Sulman
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Genomics 40:371-4. 1997
    Mouse eck, a member of the EPH gene family, has been mapped to mouse chromosome 4...
  10. ncbi Negative regulation of EphA2 receptor by Cbl
    You jie Wang
    First Department of Pathology, Hamamatsu University School of Medicine, 1 20 1, Handayama, 431 3192, Hamamatsu, Japan
    Biochem Biophys Res Commun 296:214-20. 2002
    ..Here, we report that EphA2, a member of Eph receptor tyrosine kinases is negatively regulated by Cbl...
  11. ncbi Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade
    Rebecca L Pratt
    Department of Basic Medical Sciences, Purdue University Cancer Center, West Lafayette, Indiana, IN 47907 1246, USA
    Oncogene 21:7690-9. 2002
    ..Recent studies in our laboratory and others have demonstrated that the EphA2 receptor tyrosine kinase critically regulates tumor cell growth, migration and invasiveness...
  12. ncbi Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival
    Michael S Kinch
    MedImmune, Inc, Gaithersburg, Maryland 20878, USA
    Clin Cancer Res 9:613-8. 2003
    ..Recent advances in molecular biological substaging may provide an opportunity to identify those patients with the most aggressive forms of the disease, but there is a continuing need for accurate markers of disease relapse and survival...
  13. ncbi Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer
    Hideki Kataoka
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Cancer Sci 95:136-41. 2004
    ..Expression of two of them, EFNA1 ligand and its receptor, EPHA2, has been proposed to contribute to tumor-induced neovascularization...
  14. ncbi A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis
    Wei Bin Fang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2363, USA
    Oncogene 24:7859-68. 2005
    ..One family member in particular, the EphA2 receptor, has been linked to breast, prostate, lung and colon cancer, as well as melanoma...
  15. ncbi Expression of EphA2 and Ephrin A-1 in carcinoma of the urinary bladder
    Shaji Abraham
    Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47909, USA
    Clin Cancer Res 12:353-60. 2006
    The EphA2 receptor tyrosine kinase is believed to play a role in tumor growth and metastasis. The clinical significance of the expression of EphA2 was observed in breast, prostate, colon, skin, cervical, ovarian, and lung cancers...
  16. ncbi VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: implications for vasculogenic mimicry
    Angela R Hess
    Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Cancer Biol Ther 5:228-33. 2006
    ..This study contributes new observations demonstrating that VE-cadherin can regulate the expression of EphA2 at the cell membrane by mediating its ability to become phosphorylated through interactions with its membrane ..
  17. doi Interleukin-13 receptor alpha 2, EphA2, and Fos-related antigen 1 as molecular denominators of high-grade astrocytomas and specific targets for combinatorial therapy
    Jill Wykosky
    Brain Tumor Center of Excellence, Comprehensive Cancer Center, Department of Neurosurgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Clin Cancer Res 14:199-208. 2008
    We investigated the expression of interleukin-13 receptor alpha2 (IL-13R alpha 2), EphA2, and Fos-related antigen 1 (Fra-1) in astrocytomas and normal brain...
  18. pmc EphA2 overexpression promotes ovarian cancer growth
    Chunhua Lu
    Department of Gynecologic Oncology, U T M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 7:1098-103. 2008
    Silencing EphA2 has been shown to result in anti-tumor efficacy. However, it is not known whether increasing EphA2 expression specifically results in increased tumor growth and progression...
  19. doi Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract
    Tianxiao Zhang
    Department of Ophthalmology, China Medical University, Shenyang, China
    Hum Mutat 30:E603-11. 2009
    ..dominant posterior polar CC and total CC have both been mapped to the chromosomal 1p36 region harboring the EPHA2 receptor tyrosine kinase gene...
  20. doi EFNA1 ligand and its receptor EphA2: potential biomarkers for hepatocellular carcinoma
    Xiang Dan Cui
    Division of Gastroenterology and Hepatology, The Institute for Medical Science, Department of Internal Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk, Republic of Korea
    Int J Cancer 126:940-9. 2010
    ..We further examined the expression of EFNA1 and its receptor EphA2 and determined their biological implications during the development and progression of HCC...
  21. pmc Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells
    Mayumi Kawabe
    Department of Immunology, University of Pittsburgh School of Medicine, PA 15213, USA
    Cancer Res 69:6995-7003. 2009
    b>EphA2, a member of the receptor tyrosine kinase family, is commonly expressed by a broad range of cancer types, where its level of (over)expression correlates with poor clinical outcome...
  22. pmc EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation
    Leonardo Faoro
    Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:18575-85. 2010
    Non-small cell lung cancer (NSCLC) has a poor prognosis and improved therapies are needed. Expression of EphA2 is increased in NSCLC metastases...
  23. pmc Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells
    Nai Ying Yang
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Cell Signal 23:201-12. 2011
    ..The EphA2 receptor is highly expressed in most cancer cell types, where it has disparate activities that are not well ..
  24. pmc EphA2 is a critical oncogene in melanoma
    D Udayakumar
    Department of Dermatology, Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, MA, USA
    Oncogene 30:4921-9. 2011
    b>EphA2 is a member of the Eph family of receptor tyrosine kinases and is highly expressed in many aggressive cancer types, including melanoma...
  25. pmc Mutations in the EPHA2 gene are a major contributor to inherited cataracts in South-Eastern Australia
    Alpana Dave
    Department of Ophthalmology, Flinders University, Bedford Park, SA, Australia
    PLoS ONE 8:e72518. 2013
    ..Recently, mutations in the receptor tyrosine kinase gene, EPHA2, have been found to cause congenital cataract in six different families...
  26. pmc cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases
    R A Lindberg
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, San Diego, California 92186 5800
    Mol Cell Biol 10:6316-24. 1990
    ..Analysis of RNA from 13 adult rat organs showed that the eck gene is expressed most highly in tissues that contain a high proportion of epithelial cells, e.g...
  27. ncbi Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis
    A Pandey
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    Science 268:567-9. 1995
    B61, a cytokine-inducible endothelial gene product, is the ligand for the Eck receptor protein tyrosine kinase (RPTK)...
  28. ncbi The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development
    J C Ruiz
    Department of Biochemistry, Molecular Biology, and Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138
    Mech Dev 46:87-100. 1994
    ..Here, we analyze the expression of eck, a member of the eph family of R-PTKs, during gastrulation and early organogenesis by in situ hybridization...
  29. ncbi The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development
    P Ganju
    Ludwig Institute for Cancer Research, London, UK
    Oncogene 9:1613-24. 1994
    ..for additional receptor tyrosine kinases expressed during mouse embryogenesis we cloned the murine homolog of Eck, a member of the Eph subfamily, that maps to the distal region of mouse chromosome 4...
  30. ncbi Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis
    N W Gale
    Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York, 10591 6707, USA
    Neuron 17:9-19. 1996
    ..This reciprocal compartmentalization implicates the Eph family in the formation of spatial boundaries that may help to organize the developing body plan...
  31. ncbi The ephrins and Eph receptors in neural development
    J G Flanagan
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Neurosci 21:309-45. 1998
    ..This large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system...
  32. ncbi Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
    H Miao
    Rammelkamp Center for Research, MetroHealth Campus, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA
    Nat Cell Biol 2:62-9. 2000
    ..Here we show that activation of endogenous EphA2 kinase induces an inactive conformation of integrins and inhibits cell spreading, migration and integrin-mediated ..
  33. ncbi The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization
    K Ogawa
    The Burnham Institute, La Jolla, California 92037, USA
    Oncogene 19:6043-52. 2000
    ..By immunohistochemistry, the ephrin-A1 ligand and one of its receptors, EphA2, were detected throughout tumor vasculature...
  34. ncbi Multiple roles of EPH receptors and ephrins in neural development
    D G Wilkinson
    Division of Developmental Neurobiology, National Institute for Medical Research, Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Rev Neurosci 2:155-64. 2001
    ..Eph receptor tyrosine kinases and their ephrin ligands are key players in controlling these cell movements in many tissues and at multiple stages of patterning...
  35. ncbi EphA2 overexpression correlates with poor prognosis in esophageal squamous cell carcinoma
    Tatsuya Miyazaki
    Department of Surgery I, Gunma University Faculty of Medicine, Gunma, Japan
    Int J Cancer 103:657-63. 2003
    b>EphA2 is a member of the Eph family of receptor tyrosine kinases, which interact with cell-bound ligands known as ephrins...
  36. ncbi Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis
    Nikki Cheng
    Department of Cancer Biology, Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Cancer Res 1:2-11. 2002
    ..b>EphA2 RTK is activated by VEGF through induction of ephrinA1 ligand...
  37. ncbi c-Cbl-dependent EphA2 protein degradation is induced by ligand binding
    Jennifer Walker-Daniels
    Department of Basic Medical Sciences and Medicinal Chemistry and Molecular Pharmacology, Purdue University Cancer Center, West Lafayette, IN, USA
    Mol Cancer Res 1:79-87. 2002
    The EphA2 receptor protein tyrosine kinase is overexpressed and functionally altered in a large number of human carcinomas...
  38. ncbi Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer
    Michael S Kinch
    MedImmune, Inc, Gaithersburg, Maryland 20878, USA
    Clin Exp Metastasis 20:59-68. 2003
    ..In Recent studies have demonstrated that the EphA2 receptor tyrosine kinase is frequently overexpressed and functionally altered in aggressive tumor cells, and that ..
  39. pmc Differential regulation of EphA2 in normal and malignant cells
    Jennifer Walker-Daniels
    Department of Basic Medical Sciences, Purdue University Cancer Center, West Lafayette, Indiana, USA
    Am J Pathol 162:1037-42. 2003
  40. ncbi Human dendritic cells express neuronal Eph receptor tyrosine kinases: role of EphA2 in regulating adhesion to fibronectin
    Blandine de Saint-Vis
    Laboratory for Immunological Research, Schering Plough, 27 chemin des Peupliers, BP 11, 69571 Dardilly, France
    Blood 102:4431-40. 2003
    ..showed that DCs derived from CD34+ progenitors, but not from monocytes, expressed several receptors, in particular EphA2, EphA4, EphA7, EphB1, and EphB3 mRNA...
  41. pmc High-level expression of EphA2 receptor tyrosine kinase in prostatic intraepithelial neoplasia
    Guangyuan Zeng
    Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Pathol 163:2271-6. 2003
    b>EphA2 is a transmembrane receptor tyrosine kinase that is overexpressed in many carcinomas...
  42. ncbi Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness
    Mark S Duxbury
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biochem Biophys Res Commun 320:1096-102. 2004
    The Eph tyrosine kinases interact with ligands of the Ephrin family and have diverse cellular functions. EphA2 has been recognized to be an oncoprotein of importance in a range of cancers...
  43. ncbi EphA2 expression is associated with aggressive features in ovarian carcinoma
    Premal H Thaker
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:5145-50. 2004
    b>EphA2 (epithelial cell kinase) is a transmembrane receptor tyrosine kinase that has been implicated in oncogenesis. There are no published data regarding the role of EphA2 in ovarian carcinoma, which is the focus of the present study.
  44. ncbi EPHA2/EFNA1 expression in human gastric cancer
    Ritsuko Nakamura
    First Department of Pathology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 43 3192
    Cancer Sci 96:42-7. 2005
    ..A recent report, however, indicated that stimulation of the EPHA2 receptor ligand, ephrinA1 (EFNA1), inhibits the growth of EPHA2-expressing breast cancer...
  45. ncbi Expression of EphA2 is prognostic of disease-free interval and overall survival in surgically treated patients with renal cell carcinoma
    Christopher J Herrem
    Department of Immunology and Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 1863, USA
    Clin Cancer Res 11:226-31. 2005
    ..of cell-to-cell contact in adult epithelial tissues, recent studies have shown that the receptor tyrosine kinase EphA2 is overexpressed in numerous epithelial-type carcinomas, with the greatest level of EphA2 expression observed in ..
  46. ncbi EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase
    Matteo Parri
    Department of Biochemical Sciences, University of Florence, Via le Morgagni 50, Florence 50134, Italy
    J Biol Chem 280:34008-18. 2005
    ..study aimed to investigate the role of low molecular weight protein-tyrosine phosphatase (LMW-PTP) in ephrinA1/EphA2 signaling...
  47. ncbi A conditional feedback loop regulates Ras activity through EphA2
    Madhu Macrae
    Cancer Research Institute and Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94143, USA
    Cancer Cell 8:111-8. 2005
    The EphA2 receptor tyrosine kinase is frequently overexpressed in many cancers, including 40% of breast cancers...
  48. ncbi EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability
    Masamitsu Tanaka
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 280:42375-82. 2005
    Eph receptors and ephrin ligands are widely expressed in epithelial cells and mediate cell-cell interaction. EphA2 is expressed in various cancer tissues and cell lines...
  49. pmc Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival
    Nirmitha I Herath
    Leukaemia Foundation Research Unit, University of Queensland, Australia
    BMC Cancer 6:144. 2006
    ..This report describes aberrant expression of these genes in ovarian cancer, the commonest cause of death amongst gynaecological malignancies...
  50. ncbi EphA2 overexpression is associated with angiogenesis in ovarian cancer
    Yvonne G Lin
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 109:332-40. 2007
    b>EphA2 is overexpressed in the majority of ovarian cancers and predicts poor clinical outcome...
  51. ncbi Activation of the EGFR gene target EphA2 inhibits epidermal growth factor-induced cancer cell motility
    Alice Bjerregaard Larsen
    Department of Radiation Biology, Section 6321, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Mol Cancer Res 5:283-93. 2007
    b>EphA2 overexpression has been reported in many cancers and is believed to play an important role in tumor metastasis and angiogenesis...
  52. ncbi Constitutive activation of the Raf-MAPK pathway causes negative feedback inhibition of Ras-PI3K-AKT and cellular arrest through the EphA2 receptor
    C W Menges
    Department of Biochemistry, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Oncogene 27:2934-40. 2008
    ..show that activation of Raf-MEK1 signaling causes negative feedback inhibition of Ras through the ephrin receptor EphA2. EphA2-mediated negative feedback inhibition is required for Raf-induced AKT inhibition and cell cycle arrest, ..
  53. pmc The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling
    Dana M Brantley-Sieders
    Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Invest 118:64-78. 2008
    Overexpression of the receptor tyrosine kinase EPH receptor A2 (EphA2) is commonly observed in aggressive breast cancer and correlates with a poor prognosis...
  54. ncbi Increased expression of EphA2 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients
    Lin Fang Wang
    Department of Radiation Therapy and Radiooncology, Philipps University, D 35043 Marburg, Germany
    Oncol Rep 19:151-6. 2008
    ..The EphA2 receptor tyrosine kinase plays a pivotal role in tumor angiogenesis and an increased expression in glioma patients ..
  55. pmc Comparative 3'UTR analysis allows identification of regulatory clusters that drive Eph/ephrin expression in cancer cell lines
    Jennifer Winter
    Max Planck Institute for Molecular Genetics, Berlin Dahlem, Germany
    PLoS ONE 3:e2780. 2008
    ..Together our studies suggest that overexpression of HuR as found in many progressive tumors could be causative for disarranged Eph receptor to ephrin ligand ratios leading to a higher degree of tissue invasiveness...
  56. pmc Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor
    J Wykosky
    Department of Neurosurgery, Brain Tumor Center of Excellence, Wake Forest University School of Medicine, Comprehensive Cancer Center, Winston Salem, NC 27157, USA
    Oncogene 27:7260-73. 2008
    The ephrinA1 ligand exerts antioncogenic effects in tumor cells through activation and downregulation of the EphA2 receptor and has been described as a membrane-anchored protein requiring clustering for function...
  57. pmc Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer
    Q Chang
    Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
    Br J Cancer 99:1074-82. 2008
    Eph receptors constitute the largest family of receptor tyrosine kinases in the human genome. EphA2 is one prominent member that is overexpressed and functionally altered in many invasive cancers, including pancreatic cancer...
  58. pmc The EPHA2 gene is associated with cataracts linked to chromosome 1p
    Alan Shiels
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Vis 14:2042-55. 2008
    ....
  59. doi Expression of EphA2 and E-cadherin in gastric cancer: correlated with tumor progression and lymphogenous metastasis
    Weijie Yuan
    Department of General Surgery, Xiangya Hospital, Central South University, Xiangya Road, Changsha 410008, Hunan Province, Peoples Republic of China
    Pathol Oncol Res 15:473-8. 2009
    ..Immunohistochemistry of EphA2 and E-cadherin were performed on these tumor samples from 165 primary lesions of gastric cancer...
  60. pmc The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting
    Jill Wykosky
    Department of Neurosurgery, Brain Tumor Center of Excellence, Comprehensive Cancer Center of Wake Forest University, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Mol Cancer Res 6:1795-806. 2008
    ..Among these are EphA2 and ephrinA1, which are involved in the development and maintenance of many different types of solid tumors...
  61. pmc EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts
    Koichi Miura
    Department of Molecular Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Mol Biol Cell 20:1949-59. 2009
    ..and calcium ion concentration, and we provide evidence of a novel signaling pathway by which ligand-activated EphA2 suppresses Arf6 activity...
  62. pmc EphA2 as a promoter of melanoma tumorigenicity
    Naira V Margaryan
    The Children s Memorial Research Center, Chicago, IL, USA
    Cancer Biol Ther 8:279-88. 2009
    ..b>EphA2, a protein tyrosine kinase receptor commonly expressed in epithelial cells, has been found to be overexpressed and ..
  63. pmc Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis
    Maria Letizia Taddei
    Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
    Am J Pathol 174:1492-503. 2009
    Ligand-activated Eph tyrosine kinases regulate cellular repulsion, morphology, adhesion, and motility. EphA2 kinase is frequently up-regulated in several different types of cancers, including prostate, breast, colon, and lung carcinomas, ..
  64. doi Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer
    Jennifer M Brannan
    Departments of Thoracic Head and Neck Medical Oncology, Biostatistics, and Pathology, The University of Texas M D Anderson Cancer Center, USA
    Clin Cancer Res 15:4423-30. 2009
    Up-regulation of the receptor tyrosine kinase EphA2 has been shown in several epithelial cancers...
  65. pmc EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt
    Hui Miao
    Department of Medicine, Rammelkamp Center for Research, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Cancer Cell 16:9-20. 2009
    Both pro- and antioncogenic properties have been attributed to EphA2 kinase. We report that a possible cause for this apparent paradox is diametrically opposite roles of EphA2 in regulating cell migration and invasion...
  66. pmc EPHA2 is associated with age-related cortical cataract in mice and humans
    Gyungah Jun
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS Genet 5:e1000584. 2009
    ..We report that homozygous deletion of Epha2 in two independent strains of mice developed progressive cortical cataract...
  67. doi EphA2 in the early pathogenesis and progression of non-small cell lung cancer
    Jennifer M Brannan
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Cancer Prev Res (Phila) 2:1039-49. 2009
    Overexpression of the receptor tyrosine kinase EphA2 occurs in non-small cell lung cancer (NSCLC) and a number of other human cancers...
  68. doi Prognostic role of vasculogenic mimicry in colorectal cancer
    Coen I M Baeten
    Angiogenesis Laboratory, Research Institute for Growth and Development GROW, University Hospital Maastricht, Maastricht, The Netherlands
    Dis Colon Rectum 52:2028-35. 2009
    ..We investigated angiogenesis and the presence of vasculogenic mimicry in colorectal carcinoma in relation to tumor stage, patient survival, and genetic indicators of tumor cell plasticity...
  69. pmc Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy
    Guanglei Zhuang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tenessee 37232, USA
    Cancer Res 70:299-308. 2010
    ..In this study, we provide evidence that elevated level of the receptor tyrosine kinase Eph receptor A2 (EphA2) is an important contributor to trastuzumab resistance...
  70. pmc Restriction of receptor movement alters cellular response: physical force sensing by EphA2
    Khalid Salaita
    Howard Hughes Medical Institute, Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Science 327:1380-5. 2010
    Activation of the EphA2 receptor tyrosine kinase by ephrin-A1 ligands presented on apposed cell surfaces plays important roles in development and exhibits poorly understood functional alterations in cancer...
  71. pmc An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly
    Elena Seiradake
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Struct Mol Biol 17:398-402. 2010
    ..Upon activation, they form signaling clusters. We report crystal structures of the full ectodomain of human EphA2 (eEphA2) both alone and in complex with the receptor-binding domain of the ligand ephrinA5 (ephrinA5 RBD)...
  72. pmc EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma
    Jeong Won Lee
    Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:2562-70. 2010
    b>EphA2 overexpression is frequently observed in endometrial cancers and is predictive of poor clinical outcome...
  73. pmc Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism
    Nao Hiramoto-Yamaki
    Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 190:461-77. 2010
    b>EphA2, a member of the Eph receptor family, is frequently overexpressed in a variety of human cancers, including breast cancers, and promotes cancer cell motility and invasion independently of its ligand ephrin stimulation...
  74. doi De novo expression of EphA2 in osteosarcoma modulates activation of the mitogenic signalling pathway
    Raphaela Fritsche-Guenther
    Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Histopathology 57:836-50. 2010
    ..The aim of this study was to elucidate the molecular mechanisms governing osteosarcoma development and dissemination and, thereby, to identify possible novel drug targets for improved treatment...
  75. doi EphA2 induces metastatic growth regulating amoeboid motility and clonogenic potential in prostate carcinoma cells
    Maria Letizia Taddei
    Department of Biochemical Sciences, University of Florence, Tuscany Tumor Institute, Florence, Italy
    Mol Cancer Res 9:149-60. 2011
    b>EphA2 kinase regulates cell shape, adhesion, and motility and is frequently overexpressed in several cancers, including melanoma, prostate, breast, and colon cancers and lung carcinoma...
  76. pmc A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion
    Udhayakumar Gopal
    Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 6:e17649. 2011
    ..The receptor tyrosine kinase EphA2 is overexpressed in the majority of GBM specimens and is a critical mediator of GBM invasiveness through its AKT ..
  77. pmc Association of EPHA2 polymorphisms and age-related cortical cataract in a Han Chinese population
    Wei Tan
    Department of Ophthalmology, Research Institute of Field Surgery, Da Ping Hospital, Third Military Medical University, Chongqing, PR China
    Mol Vis 17:1553-8. 2011
    The gene for Eph-receptor tyrosinekinase-type A2 (EPHA2) has been shown to be involved in the pathogenesis of age-related cataract (ARC)...
  78. pmc Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome
    Dana M Brantley-Sieders
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United State of America
    PLoS ONE 6:e24426. 2011
    ..We found significant correlations between ephA2, ephA4, ephA7, ephB4, and ephB6 and overall and/or recurrence-free survival in large microarray datasets...
  79. pmc Kaposi's sarcoma-associated herpesvirus interacts with EphrinA2 receptor to amplify signaling essential for productive infection
    Sayan Chakraborty
    H M Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    Proc Natl Acad Sci U S A 109:E1163-72. 2012
    ..The tyrosine kinase EphrinA2 (EphA2), implicated in many cancers, was identified in this analysis. EphA2 was activated by KSHV...
  80. pmc Human cataract mutations in EPHA2 SAM domain alter receptor stability and function
    Jeong Eun Park
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, USA
    PLoS ONE 7:e36564. 2012
    ..In recent studies, several mutations in the cytoplasmic sterile-α-motif (SAM) domain of human EPHA2 on chromosome 1p36 have been associated with hereditary cataracts in several families...
  81. pmc The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma–associated herpesvirus
    Alexander S Hahn
    Virologisches Institut, Universitatsklinikum Erlangen, Erlangen, Germany
    Nat Med 18:961-6. 2012
    ..We show that the ephrin receptor tyrosine kinase A2 (EphA2) is a cellular receptor for KSHV gH-gL. EphA2 co-precipitated with both gH-gL and KSHV virions...
  82. pmc Association of the ephreceptor tyrosinekinase-type A2 (EPHA2) gene polymorphism rs3754334 with age-related cataract risk: a meta-analysis
    Jin Yang
    Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China
    PLoS ONE 8:e71003. 2013
    ..clinical studies have assessed the association of various polymorphisms on the ephreceptor tyrosinekinase-type A2 (EPHA2) with the risk for age-related cataract in populations of different ethnic/racial backgrounds, but inconsistent ..
  83. ncbi Expression of EphA2 in human astrocytic tumors: correlation with pathologic grade, proliferation and apoptosis
    Xia Li
    Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Tumour Biol 28:165-72. 2007
    A high expression of EphA2 has been detected in many non-central nervous system tumors; however, the EphA2 expression in brain astrocytic tumors remains unclear...
  84. pmc EphA2 is an essential mediator of UV radiation-induced apoptosis
    Guoqi Zhang
    Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 68:1691-6. 2008
    ..In a recent global screen of UVR response genes in melanocytes, we identified the receptor tyrosine kinase EPHA2. Using a combination of genetic and pharmacologic approaches, we set out to investigate the upstream regulation of ..
  85. doi Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma
    Constantinos Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75 Mikras Asias Str, Athens, 11527, Greece
    Pathol Oncol Res 16:267-76. 2010
    ....
  86. ncbi Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase
    Daniel P Zelinski
    Department of Basic Medical Sciences, Purdue University Cancer Center, West Lafayette, Indiana 47907, USA
    J Cell Biochem 85:714-20. 2002
    ..High levels of the EphA2 tyrosine kinase are consistently found in the most aggressive breast cancer cells, and EphA2 overexpression can ..
  87. ncbi LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain
    C J Kozlosky
    Department of Molecular Biology, Immunex Research and Development Corporation, 51 University Street, Seattle, WA, 98101, USA
    Cytokine 9:540-9. 1997
    ..In addition, a soluble form of LERK-7 will induce phosphorylation of eck expressed in a human duodenum adenocarcinoma cell line. LERK-7 expressed multiple transcripts (7.5-kb, 6...
  88. ncbi Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
    Jacek Nowakowski
    Syrrx, Inc, 10410 Science Center Drive, San Diego, CA 92121, USA
    Structure 10:1659-67. 2002
    ..report presents the structures of kinase domains for three cancer-associated protein kinases: ephrin receptor A2 (EphA2), focal adhesion kinase (FAK), and Aurora-A...
  89. ncbi Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues
    Keijo Luukko
    Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Cell Tissue Res 319:143-52. 2005
    ..roles of the ephrin-Eph system in tooth formation, we studied the cellular mRNA expression of Ephrin-A1-A5 and EphA2, EphA3, EphA4, EphA7, and EphA8 receptors during embryonic histomorphogenesis of the mouse first molar (embryonic ..
  90. ncbi Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation
    Guanglei Zhuang
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 282:2683-94. 2007
    ..In particular, ephrin-A ligand stimulation of tumor cells induces EphA2 receptor internalization and degradation, a process that has been explored as a means to reduce tumor malignancy...
  91. ncbi Inhibition of retinal neovascularization by soluble EphA2 receptor
    Jin Chen
    Department of Medicine, Division of Rheumatology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Exp Eye Res 82:664-73. 2006
    ..Soluble EphA2-Fc receptors inhibited ephrin-A1 ligand or VEGF-induced BRMEC migration and tube formation without affecting ..
  92. pmc The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction
    Polina Goichberg
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Circ Res 108:1071-83. 2011
    ..Understanding the mechanisms that regulate trafficking of human cardiac stem cells (hCSCs) may lead to development of new therapeutic approaches for the failing heart...
  93. ncbi EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation
    Dana M Brantley-Sieders
    Division of Rhematology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Cell Sci 117:2037-49. 2004
    ..Here, we report that EphA2 regulates endothelial cell assembly and migration through phosphoinositide (PI) 3-kinase-mediated activation of ..
  94. pmc Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors
    Roberta Noberini
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 283:29461-72. 2008
    ..to promiscuously bind many Eph receptors, the two compounds selectively target EphA4 and the closely related EphA2 receptor...
  95. pmc Activation of rabbit platelets by Ca2+ influx and thromboxane A2 release in an external Ca(2+)-dependent manner by zooxanthellatoxin-A, a novel polyol
    M C Rho
    Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Br J Pharmacol 115:433-40. 1995
    ..The resulting increase in [Ca2+]i subsequently stimulates the secondary release of TXA2 from platelets. Furthermore, the response to ZT-A may be associated with tyrosine phosphorylation...
  96. pmc Specificity of HCPTP variants toward EphA2 tyrosines by quantitative selected reaction monitoring
    Deepa Balasubramaniam
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Protein Sci 20:1172-81. 2011
    b>EphA2 receptor tyrosine kinase and the human cytoplasmic protein tyrosine phosphatase (HCPTP) are overexpressed in a number of epithelial cancers...
  97. pmc Anti-EphA2 Antibodies with Distinct In Vitro Properties Have Equal In Vivo Efficacy in Pancreatic Cancer
    Helenia Ansuini
    Istituto di Ricerca di Biologia Molecolare P Angeletti, Pomezia, 00040 Roma, Italy
    J Oncol 2009:951917. 2009
    The EphA2 receptor tyrosine kinase is overexpressed in a variety of human epithelial cancers and is a determinant of malignant cellular behavior in pancreatic adenocarcinoma cells...
  98. pmc Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase
    Wei Bin Fang
    Department of Cancer Biology, Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 283:16017-26. 2008
    b>EphA2 is a member of the Eph family of receptor tyrosine kinases. EphA2 mediates cell-cell communication and plays critical roles in a number of physiological and pathologic responses...
  99. pmc Structure-activity relationship analysis of peptides targeting the EphA2 receptor
    Sayantan Mitra
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 49:6687-95. 2010
    The EphA2 receptor tyrosine kinase has emerged as a promising new therapeutic target in cancer because of its high level of expression in tumors...
  100. ncbi Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression
    Dana M Brantley-Sieders
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2363, USA
    FASEB J 19:1884-6. 2005
    b>EphA2 belongs to a unique family of receptor tyrosine kinases that play critical roles in development and disease...
  101. pmc Expression and functional effects of Eph receptor tyrosine kinase A family members on Langerhans like dendritic cells
    Else Munthe
    Department of Immunology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    BMC Immunol 5:9. 2004
    ..Previously, the expression of a member of this family, EphA2, was identified on dendritic like cells in tonsils...

Research Grants69

  1. Jack T Stapleton; Fiscal Year: 2016
    ..Identification and characterization of this HCV E2 - lymphocyte interaction may contribute to the development of novel therapeutic and/or vaccine approaches to HCV, and potentially to related viruses within the Flaviviridae. ..
  2. Michael J Mullan; Fiscal Year: 2014
    ..We have identified CD40 signaling as a potentially key modulator of both amyloid and tau pathology and this proposal seeks to identify downstream molecules which are more tractable from a drug development perspective. ..
  3. Copolymer hydrogel microspheres for analysis of kinase activity in cell lysates
    Sean P Palecek; Fiscal Year: 2010
    ..This assay will likely be more rapid and less expensive than current methods, and have the advantage of predicting response to drug treatment. ..
  4. Bingcheng Wang; Fiscal Year: 2014
    Abstract: The overarching goal of this project is to evaluate the role of reciprocal regulation between EphA2 and Akt in glioma invasion and to understand the underlying molecular mechanisms...
  5. An allosteric inhibitor of ZAP-70 as a novel therapeutic for autoimmune disease
    Arthur Weiss; Fiscal Year: 2010
    ....
  6. STRUCTURAL STUDY OF THE INSULIN RECEPTOR TYROSINE KINASE
    Stevan R Hubbard; Fiscal Year: 2010
    ..By understanding at the molecular level how the insulin receptor is regulated, we hope to facilitate efforts to design small-molecule agonists and inhibitors that could potentially be used as anti-diabetic therapeutics. ..
  7. Carol B Post; Fiscal Year: 2016
    ..The proposed research aims to elucidate mechanisms of this control for Syk and Src PTKs with the goal of contributing new knowledge that is useful in fighting human disease. ..
  8. ARTHUR ROBERT SALOMON; Fiscal Year: 2014
    ..Testing of a newly postulated, phosphoproteomic data-inspired hypothesis about the Zap-70 dependent regulation of Fyn kinase through PTPa will be explored with classical molecular approaches. ..
  9. Src Family Kinases as Molecular Targets for HIV/Nef
    THOMAS EDWARD SMITHGALL; Fiscal Year: 2010
    ..Our work is focused on the interaction of Nef with protein kinases in infected cells. Completion of these experiments will validate these Nef-kinase complexes as targets for the discovery of new anti-HIV therapeutics. ..
  10. Complexes of HIV-1 Nef with Src-family Kinases as Therapeutic Targets
    Lori A Emert Sedlak; Fiscal Year: 2010
    ..This compound represents the first to target a viral protein:host cell protein kinase complex, providing a new lead for anti-HIV drug development. ..
  11. Direct identification of ready-to-use peptoid-DOTA theranostic systems
    DAMITH GOMIKA UDUGAMASOORIYA; Fiscal Year: 2013
    ..This library will be screened against Epidermal Growth Factor Receptor (EGFR) and ephrin receptor A2 (EphA2) as model target systems that overexpress in many cancer types which ideally form multimeric clusters on the cell ..
  12. Bingcheng Wang; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): There are two major goals in this proposal. One is to elucidate if Akt-EphA2 signaling axis is a "driver" mechanism underlying malignant progression of human prostate cancer (PCa);the other is to ..
  13. Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes
    Jan Novak; Fiscal Year: 2012
    ..Relevance: The improved understanding of the pathogenesis of IgAN will identify therapeutic targets for disease-specific therapy of IgAN as well as potential prognostic biomarkers. ..
  14. NATHANAEL SCHIANDER GRAY; Fiscal Year: 2015
    ..Emerging evidence suggests that abnormal EphA2 kinase activity plays a key role in many types of cancers, including breast, lung, ovary, prostate, glioblastoma, ..
  15. Optimization of EphA4 antagonists for CNS disorders
    ELENA B contact PASQUALE; Fiscal Year: 2010
    ..compounds that we have identified and extensively characterized, while highly selective for EphA4 and the related EphA2 receptor, have low potency...
  16. Mechanisms of H. pylori-Induced Hypochlorhydria
    Adam J Smolka; Fiscal Year: 2010
    ..Improved mechanistic understanding of H. pylori pathophysiology will inform later studies in translational models and in humans. ..
  17. Modulation of T cell Homeostasis in Myelodysplastic Syndrome (MDS)
    Javier Pinilla; Fiscal Year: 2012
    ..Mechanistic studies will aide our understanding of T-cell immunity and improve our ability to utilize this form of immunotherapy and other forms for the treatment of cancer in general. ..
  18. WILLIAM SCHIEMANN; Fiscal Year: 2016
    ..g., c-Abl for docetaxel response) and treatment options (e.g., Securinine and DPH) for TNBCs. ..
  19. Syk blockade in bullous skin diseases
    Uma Sinha; Fiscal Year: 2012
    ..In this Phase I program we will provide proof-of-concept for Syk inhibitors in BP using both animal models and relevant ex vivo human biospecimens. ..
  20. William G Cance; Fiscal Year: 2016
    ..Thus, this application will provide novel molecular cancer therapeutics that target the focal adhesion kinase. ..
  21. William J Snell; Fiscal Year: 2016
    ..Studying flagellar adhesion and flagellar shortening in Chlamydomonas will continue to uncover novel and fundamental properties of these remarkable organelles. ..
  22. Mechanisms of Breast Tumor Cell Growth, Motility, and Antiestrogen Response
    Amy H Bouton; Fiscal Year: 2013
    ..abstract_text> ..
  23. Spiro Getsios; Fiscal Year: 2016
    ..for long-term gene silencing and reconstitution will be employed to define the reciprocal roles for EphA1 and EphA2 in epidermal differentiation and morphogenesis...
  24. The role of BMX in Lymphangiogenesis
    Dennis Jones; Fiscal Year: 2011
    ..Ultimately novel inhibitor molecules against Bmx may be effective in cancer therapy. ..
  25. Paul J Chiao; Fiscal Year: 2014
    ..Targeting specific mutations and signaling pathways in pancreatic cancer may be one of the novel therapeutic interventions to treat cancer metastasis. ..
  26. Waldemar Debinski; Fiscal Year: 2014
    ..Furthermore, another receptor, EphA2 tyrosine kinase receptor, was found to be elevated in a large number of GBM specimens and cell lines, but not in ..
  27. Jin Chen; Fiscal Year: 2016
    ..ephrin-A1 promotes tumor metastasis through coordinated induction of angiogenic factors and direct activation of EphA2 receptors on vascular endothelial cells...
  28. KATHERINE RENEE AMATO HASTINGS; Fiscal Year: 2014
    ..One tyrosine kinase that has been shown to play a significant role in EGFR TKI resistance is EphA2. Preliminary data from our lab has shown that EphA2 is upregulated in many lung cancer cell lines and is further ..
  29. A Tumor Suppressor Function for the c-Fes Tyrosine Kinase in Colon Cancer
    THOMAS EDWARD SMITHGALL; Fiscal Year: 2012
    ..If c-fes is a true tumor suppressor, then mice lacking c-fes function are expected to develop more severe disease in terms of tumor size, number, and invasiveness. ..
  30. MerTK regulation of the PTTG and RPE phagocytosis
    Qingxian Lu; Fiscal Year: 2012
    ..The data from these studies is expected to provide us the new knowledge and understanding of the RPE function, which will allow us to develop and implement new therapies for treatment of RP caused by RPE dysfunction. ..
  31. Dissecting Wnt/PCP Signaling in Developing Cochlear Sensory Epithelium
    Xiaowei Lu; Fiscal Year: 2012
    ....
  32. Cell-based screening for EphA2 receptor inhibitors
    Elena B Pasquale; Fiscal Year: 2011
    The EphA2 receptor tyrosine kinase is a promising new target for inhibition of tumor angiogenesis and other forms of pathological angiogenesis...
  33. Small Molecule Inhibitors of ZAP-70 for the Treatment of Autoimmune Disorders
    Mark Gallop; Fiscal Year: 2013
    ....
  34. Methodology for Identification of Substrate-Competitive Kinase Inhibitors
    Matthew B Soellner; Fiscal Year: 2012
    ..Our methodology will initially focus on two kinases involved in cancer (c-Abl and c-Src) and two kinases involved in African sleeping sickness. ..
  35. DAVID BRAM LEWIS; Fiscal Year: 2014
    ....
  36. ANTIBODY V GENE EXPRESSION B CELL LYMPHOCYTIC LEUKEMIA
    Thomas J Kipps; Fiscal Year: 2013
    ..Further studies could enable us to refine this approach toward development of truly effective immune therapy for patients with this disease. ..
  37. Timothy A Springer; Fiscal Year: 2015
    ..Project 6 (Eck) examines signaling at focal adhesions and explores activation of the tyrosine kinase of FAK by ..
  38. Hsp90 Regulates EphA2 Signaling and Cell Migration in Glioblastoma
    Jennifer S Isaacs; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hsp90 regulates EphA2 signaling and cell migration in glioblastoma...
  39. Jin Chen; Fiscal Year: 2016
    ..This application will specifically determine the role of EphA2 receptor tyrosine kinase in intrinsic and acquired resistant to EGFR/HER2 inhibitors...
  40. Pathogenic Role of Islet Cell Autoantibodies in Type I Diabetes
    Raphael A Clynes; Fiscal Year: 2011
    ..abstract_text> ..
  41. Alex Y Strongin; Fiscal Year: 2014
    ..Precise analysis of the MT1-MMP functionality will pave the way for rational design of inhibitory molecules directed against its specific enzymatic and non-enzymatic functions. ..
  42. Regulation of breast cancer progression by FAK expression in tumor macrophages
    J Thomas Parsons; Fiscal Year: 2010
    ..It is anticipated that, through the knowledge gained from these studies, there will be a significant reduction in mortality from breast cancer. ..
  43. Angela L Tyner; Fiscal Year: 2016
    ..Colon cancer becomes deadly after it metastasizes. Understanding the functions of PTK6 in the normal colon and in colon cancer initiation and progression will be critical for evaluating its potential as a therapeuic target. ..
  44. Recent Thymic Emigrants of the CD4 T-cell Lineage
    David Lewis; Fiscal Year: 2009
    ..Together, these studies will substantially enhance our understanding of the role of thymic RTE production in maintaining the peripheral na[unreadable]ve CD4 T-cell compartment in health and disease. ..
  45. Karsten Sauer; Fiscal Year: 2014
    ..This will aid the development of more selective, less side-effect and less drug-resistance prone therapeutics. ..
  46. Elena B Pasquale; Fiscal Year: 2014
    ..Component 3 will also develop peptide-drug conjugates to selectively target cells expressing the EphA2 receptor in tumors, an approach complementary to using agents that interfere with Eph receptor/ephrin biological ..
  47. The role of EphA2 receptor signaling in host-tumor interactions
    Dana M Brantley Sieders; Fiscal Year: 2010
    ..b>EphA2 receptor tyrosine kinase, which is expressed tumor endothelium, is a key regulator of tumor angiogenesis in vivo...
  48. Src inhibition in Colorectal Cancer
    Scott Kopetz; Fiscal Year: 2012
    ..Successful implementation will improve the effectiveness of current chemotherapies for metastatic colorectal cancer, resulting in improved outcomes for the metastatic colorectal cancer population. ..
  49. ZAP-70 Deficiency: A model for gene therapy studies
    Naomi Taylor; Fiscal Year: 2010
    ..Altogether, the data emerging from these experiments should promote the development of an optimal and safe gene therapy strategy for patients with ZAP-70-deficiency as well as other forms of SCID. ..
  50. Tumor and PTK-Targeted Therapy by FUS1 and PTK inhibitor
    Lin Ji; Fiscal Year: 2010
    ....
  51. Robin S Goland; Fiscal Year: 2014
    ..As a key component of this TrialNet application, we propose an intervention study to investigate its efficacy in human subjects with new-onset T1DM (onset within 100 days of randomization). ..
  52. David S Lawrence; Fiscal Year: 2016
    ..A new breed of imaging reagents, with properties that display a high degree of spatial (and temporal) resolution, will be prepared to address this unexpected change in direction of cancer research. ..
  53. Matthew L Meyerson; Fiscal Year: 2016
    ..The collaborative efforts of the Eck and Meyerson laboratories for the past seven years have focused on understanding the structure-function ..
  54. HIV protection by ZFN-based disruption of CCR5 gene in Hematopoietic stem cells
    Haoquan Wu; Fiscal Year: 2013
    ....
  55. Allosteric Inhibitor Discovery Technology for Protein Kinases
    THOMAS EDWARD SMITHGALL; Fiscal Year: 2013
    ..g., Fes, Src and Tec/Btk kinase families). ..
  56. Alan Shiels; Fiscal Year: 2016
    ..Recently, variations in the gene encoding one of these receptors, EPHA2, have been associated with inherited and age-related forms of human cataract, and EPHA2 has been identified as an ..
  57. C-FES PROTEIN-TYROSINE KINASE IN MYELOID DIFFERENTIATION
    Robert Glazer; Fiscal Year: 1993
    ..Cognizance of this regulatory process should aid in the design of differentiation- specific therapies for myeloid leukemias...
  58. Stevan R Hubbard; Fiscal Year: 2014
    ..To achieve this goal, x-ray crystallography will be employed to determine the three-dimensional structures of the pseudokinase domain and the tandem pseudokinase and tyrosine kinase domains. ..
  59. Transition Pathways for Biomolecular Systems: Theory and Computation
    Robert D Skeel; Fiscal Year: 2010
    ..However, this also requires the availability of sophisticated software employing advanced mathematics, whose development is the aim of this project. ..
  60. Structural determinants of promiscuity and selectivity iin Ephrin_Eph binding.
    Peter Kuhn; Fiscal Year: 2010
    This proposal will delineate the structural features of a group of Eph receptors (EphB2, EphA2, and EphA4) in their apo forms as well as in complex with their cognate ligands and peptides...
  61. PROTEIN TYROSINE KINASE TYRO-3
    ANNE PRIETO; Fiscal Year: 2003
    ..Through these efforts we hope to uncover the role of Tyro-3 in molecular mechanisms of cell adhesion, intracellular signaling and neuroplasticity in the normal and diseases nervous system. ..
  62. EphA2 Agonists as Novel Inhibitors of Tumor Progression
    Bingcheng Wang; Fiscal Year: 2007
    The overall objective of this proposal is to test whether EphA2 kinase agonists can inhibit prostate cancer progression through novel negative signaling pathways identified in the applicant's laboratory...
  63. EphA2 Receptor Tyrosine Kinase in Malignant Tumor Cell
    Jin Chen; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): EphA2 receptor is a member of the recently cloned Eph family receptor tyrosine kinases (RTKs) that overexpressed in a variety of malignant tumors...
  64. Richard L Maas; Fiscal Year: 2016
    ..For Aim 2, we have focused on a ligand-receptor pair, Ephrin A5 and its receptor Epha2, that when mutated appears to phenocopy the Tdrd7 null mutant...
  65. Targeted Intervention Against EphA2 on Cancer Cells
    DEBORAH KNAPP; Fiscal Year: 2004
    ..in monoclonal antibody production and identified dramatic changes in the expression and function of the EphA2 tyrosine kinase in malignant carcinomas...
  66. Identification of Signaling Targets of EphA2
    Sonja Schmidt; Fiscal Year: 2005
    This proposal aims to better understand the signal transduction process mediating EphA2 receptor activation to endothelial cell (EC) migration...
  67. Combinational Immunotherapies Targeting Tumor RTKs
    Walter Storkus; Fiscal Year: 2009
    ..We have recently discovered that renal cell carcinomas (RCC) over-express the receptor tyrosine kinase (RTK) EphA2 relative to normal kidney tissue, and that this is associated with an enhanced metastatic phenotype and an adverse ..
  68. SIGNAL TRANSDUCTION BY THE ECK RECEPTOR TYROSINE KINASE
    Claudius Vincenz; Fiscal Year: 1999
    ..The Eph family is the largest subfamily of RPTKs with 13 members having been discovered to date. Eck was the first member of this subfamily for which a ligand was characterized...