F10

Summary

Gene Symbol: F10
Description: coagulation factor X
Alias: FXA, coagulation factor X, Stuart-Prower factor, factor X, factor Xa, prothrombinase
Species: human
Products:     F10

Top Publications

  1. Bradford H, Micucci J, Krishnaswamy S. Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrate. J Biol Chem. 2010;285:328-38 pubmed publisher
    b>Prothrombinase converts prothrombin to thrombin via cleavage at Arg(320) followed by cleavage at Arg(271)...
  2. Alba R, Bradshaw A, Parker A, Bhella D, Waddington S, Nicklin S, et al. Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. Blood. 2009;114:965-71 pubmed publisher
    Recent studies have demonstrated the importance of coagulation factor X (FX) in adenovirus (Ad) serotype 5-mediated liver transduction in vivo. FX binds to the adenovirus hexon hypervariable regions (HVRs)...
  3. Han X, Fiehler R, Broze G. Isolation of a protein Z-dependent plasma protease inhibitor. Proc Natl Acad Sci U S A. 1998;95:9250-5 pubmed
    ..The procoagulant activity of factor Xa in a one-stage plasma coagulation assay is reduced when factor Xa is first incubated with PZ...
  4. Samama M, Martinoli J, LeFlem L, Guinet C, Plu Bureau G, Depasse F, et al. Assessment of laboratory assays to measure rivaroxaban--an oral, direct factor Xa inhibitor. Thromb Haemost. 2010;103:815-25 pubmed publisher
    ..Standard methods for HepTest and two-step prothrombinase-induced clotting time (PiCT) resulted in a paradoxical response, with low concentrations of rivaroxaban ..
  5. Barrett Y, Wang Z, Frost C, Shenker A. Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay. Thromb Haemost. 2010;104:1263-71 pubmed publisher
    Apixaban and other factor Xa (FXa) inhibitors are in late-stage clinical development for prevention and treatment of thromboembolic diseases...
  6. Murakami M, Rios Steiner J, Weaver S, Tulinsky A, Geiger J, Arni R. Intermolecular interactions and characterization of the novel factor Xa exosite involved in macromolecular recognition and inhibition: crystal structure of human Gla-domainless factor Xa complexed with the anticoagulant protein NAPc2 from the hematop. J Mol Biol. 2007;366:602-10 pubmed
    ..blood coagulation pathway by a two step mechanism, initially interacting with the hitherto uncharacterized factor Xa exosite involved in macromolecular recognition and subsequently inhibiting factor VIIa (K(i)=8...
  7. Orcutt S, Pietropaolo C, Krishnaswamy S. Extended interactions with prothrombinase enforce affinity and specificity for its macromolecular substrate. J Biol Chem. 2002;277:46191-6 pubmed
    ..of active site docking by unique substrate residues preceding the scissile bond to the function of prothrombinase. Mutagenesis of the authentic P(1)-P(3) sequence in prethrombin 2/fragment 1...
  8. Krishnaswamy S. Prothrombinase complex assembly. Contributions of protein-protein and protein-membrane interactions toward complex formation. J Biol Chem. 1990;265:3708-18 pubmed
    Equilibrium binding studies of prothrombinase complex formation were undertaken using phospholipid vesicles composed of phosphatidylcholine and phosphatidylserine (PCPS), factor Va, and factor Xa modified with dansyl ..
  9. Scotton C, Krupiczojc M, Konigshoff M, Mercer P, Lee Y, Kaminski N, et al. Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest. 2009;119:2550-63 pubmed publisher
    ..Here we report that expression of coagulation factor X (FX) is locally increased in human and murine fibrotic lung tissue, with marked immunostaining associated ..
  10. Kamath P, Krishnaswamy S. Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase. J Biol Chem. 2008;283:30164-73 pubmed publisher
    ..mediated by its N-terminal fragment 1 (F1) domain, plays an essential role in its proteolytic activation by prothrombinase. Thrombin is produced in two cleavage reactions...

Detail Information

Publications62

  1. Bradford H, Micucci J, Krishnaswamy S. Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrate. J Biol Chem. 2010;285:328-38 pubmed publisher
    b>Prothrombinase converts prothrombin to thrombin via cleavage at Arg(320) followed by cleavage at Arg(271)...
  2. Alba R, Bradshaw A, Parker A, Bhella D, Waddington S, Nicklin S, et al. Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. Blood. 2009;114:965-71 pubmed publisher
    Recent studies have demonstrated the importance of coagulation factor X (FX) in adenovirus (Ad) serotype 5-mediated liver transduction in vivo. FX binds to the adenovirus hexon hypervariable regions (HVRs)...
  3. Han X, Fiehler R, Broze G. Isolation of a protein Z-dependent plasma protease inhibitor. Proc Natl Acad Sci U S A. 1998;95:9250-5 pubmed
    ..The procoagulant activity of factor Xa in a one-stage plasma coagulation assay is reduced when factor Xa is first incubated with PZ...
  4. Samama M, Martinoli J, LeFlem L, Guinet C, Plu Bureau G, Depasse F, et al. Assessment of laboratory assays to measure rivaroxaban--an oral, direct factor Xa inhibitor. Thromb Haemost. 2010;103:815-25 pubmed publisher
    ..Standard methods for HepTest and two-step prothrombinase-induced clotting time (PiCT) resulted in a paradoxical response, with low concentrations of rivaroxaban ..
  5. Barrett Y, Wang Z, Frost C, Shenker A. Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay. Thromb Haemost. 2010;104:1263-71 pubmed publisher
    Apixaban and other factor Xa (FXa) inhibitors are in late-stage clinical development for prevention and treatment of thromboembolic diseases...
  6. Murakami M, Rios Steiner J, Weaver S, Tulinsky A, Geiger J, Arni R. Intermolecular interactions and characterization of the novel factor Xa exosite involved in macromolecular recognition and inhibition: crystal structure of human Gla-domainless factor Xa complexed with the anticoagulant protein NAPc2 from the hematop. J Mol Biol. 2007;366:602-10 pubmed
    ..blood coagulation pathway by a two step mechanism, initially interacting with the hitherto uncharacterized factor Xa exosite involved in macromolecular recognition and subsequently inhibiting factor VIIa (K(i)=8...
  7. Orcutt S, Pietropaolo C, Krishnaswamy S. Extended interactions with prothrombinase enforce affinity and specificity for its macromolecular substrate. J Biol Chem. 2002;277:46191-6 pubmed
    ..of active site docking by unique substrate residues preceding the scissile bond to the function of prothrombinase. Mutagenesis of the authentic P(1)-P(3) sequence in prethrombin 2/fragment 1...
  8. Krishnaswamy S. Prothrombinase complex assembly. Contributions of protein-protein and protein-membrane interactions toward complex formation. J Biol Chem. 1990;265:3708-18 pubmed
    Equilibrium binding studies of prothrombinase complex formation were undertaken using phospholipid vesicles composed of phosphatidylcholine and phosphatidylserine (PCPS), factor Va, and factor Xa modified with dansyl ..
  9. Scotton C, Krupiczojc M, Konigshoff M, Mercer P, Lee Y, Kaminski N, et al. Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest. 2009;119:2550-63 pubmed publisher
    ..Here we report that expression of coagulation factor X (FX) is locally increased in human and murine fibrotic lung tissue, with marked immunostaining associated ..
  10. Kamath P, Krishnaswamy S. Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase. J Biol Chem. 2008;283:30164-73 pubmed publisher
    ..mediated by its N-terminal fragment 1 (F1) domain, plays an essential role in its proteolytic activation by prothrombinase. Thrombin is produced in two cleavage reactions...
  11. Bradshaw A, Parker A, Duffy M, Coughlan L, Van Rooijen N, Kahari V, et al. Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X. PLoS Pathog. 2010;6:e1001142 pubmed publisher
    Human adenoviruses from multiple species bind to coagulation factor X (FX), yet the importance of this interaction in adenovirus dissemination is unknown...
  12. Bukys M, Blum M, Kim P, Brufatto N, Nesheim M, Kalafatis M. Incorporation of factor Va into prothrombinase is required for coordinated cleavage of prothrombin by factor Xa. J Biol Chem. 2005;280:27393-401 pubmed
    ..Kinetic constants for the overall activation of prothrombin by prothrombinase assembled with saturating concentrations of recombinant mutant factor Va were calculated, prothrombin ..
  13. Rezaie A, Kittur F. The critical role of the 185-189-loop in the factor Xa interaction with Na+ and factor Va in the prothrombinase complex. J Biol Chem. 2004;279:48262-9 pubmed
    ..Both prothrombinase and direct binding studies indicated that K186A also has an approximately 6-fold impaired affinity for factor ..
  14. Orfeo T, Brufatto N, Nesheim M, Xu H, Butenas S, Mann K. The factor V activation paradox. J Biol Chem. 2004;279:19580-91 pubmed
    The prothrombinase complex consists of the protease factor Xa, Ca2+, and factor Va assembled on an anionic membrane...
  15. Ahmad S, London F, Walsh P. Binding studies of the enzyme (factor IXa) with the cofactor (factor VIIIa) in the assembly of factor-X activating complex on the activated platelet surface. J Thromb Haemost. 2003;1:2348-55 pubmed
    ....
  16. Kalafatis M, Beck D. Identification of a binding site for blood coagulation factor Xa on the heavy chain of factor Va. Amino acid residues 323-331 of factor V represent an interactive site for activated factor X. Biochemistry. 2002;41:12715-28 pubmed
    ..each) spanning amino acid region 307-351 of the heavy chain of factor Va and tested them for inhibition of prothrombinase activity...
  17. Kalyuzhniy O, Di Paolo N, Silvestry M, Hofherr S, Barry M, Stewart P, et al. Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo. Proc Natl Acad Sci U S A. 2008;105:5483-8 pubmed publisher
    ..Here, we report that the major Ad5 capsid protein, hexon, binds human coagulation factor X (FX) with an affinity of 229 pM...
  18. Yegneswaran S, Mesters R, Griffin J. Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex. J Biol Chem. 2003;278:33312-8 pubmed
    To identify amino acid sequences in factor Xa (fXa) and prothrombin (fII) that may be involved in prothrombinase complex (fXa.factor Va.fII...
  19. Bianchini E, Orcutt S, Panizzi P, Bock P, Krishnaswamy S. Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase. Proc Natl Acad Sci U S A. 2005;102:10099-104 pubmed
    b>Prothrombinase catalyzes thrombin formation by the ordered cleavage of two peptide bonds in prothrombin...
  20. Waddington S, McVey J, Bhella D, Parker A, Barker K, Atoda H, et al. Adenovirus serotype 5 hexon mediates liver gene transfer. Cell. 2008;132:397-409 pubmed publisher
    ..Liver infection by the FX-Ad5 complex is mediated through a heparin-binding exosite in the FX serine protease domain. This study reveals an unanticipated function for hexon in mediating liver gene transfer in vivo...
  21. Sierko E, Wojtukiewicz M, Zimnoch L, Tokajuk P, Ostrowska Cichocka K, Kisiel W. Co-localization of Protein Z, Protein Z-Dependent protease inhibitor and coagulation factor X in human colon cancer tissue: implications for coagulation regulation on tumor cells. Thromb Res. 2012;129:e112-8 pubmed publisher
    ..The Protein Z (PZ)/protein Z-dependent protease inhibitor (ZPI) complex directly inhibits factor Xa proteolytic activity...
  22. Bukys M, Kim P, Nesheim M, Kalafatis M. A control switch for prothrombinase: characterization of a hirudin-like pentapeptide from the COOH terminus of factor Va heavy chain that regulates the rate and pathway for prothrombin activation. J Biol Chem. 2006;281:39194-204 pubmed
    ..COOH terminus of the heavy chain of factor Va (Asp-Tyr-Asp-Tyr-Gln, DYDYQ) inhibits prothrombin activation by prothrombinase in a competitive manner with respect to substrate...
  23. Rios Steiner J, Murakami M, Tulinsky A, Arni R. Active and exo-site inhibition of human factor Xa: structure of des-Gla factor Xa inhibited by NAP5, a potent nematode anticoagulant protein from Ancylostoma caninum. J Mol Biol. 2007;371:774-86 pubmed
    ..One of these nematode anticoagulant proteins, NAP5, inhibits the amidolytic activity of factor Xa (fXa) with K(i)=43 pM, and is the most potent natural fXa inhibitor identified thus far...
  24. Venkateswarlu D, Perera L, Darden T, Pedersen L. Structure and dynamics of zymogen human blood coagulation factor X. Biophys J. 2002;82:1190-206 pubmed
    The solution structure and dynamics of the human coagulation factor X (FX) have been investigated to understand the key structural elements in the zymogenic form that participates in the activation process...
  25. Millar D, Elliston L, Deex P, Krawczak M, Wacey A, Reynaud J, et al. Molecular analysis of the genotype-phenotype relationship in factor X deficiency. Hum Genet. 2000;106:249-57 pubmed
    b>Factor X deficiency is a rare haemorrhagic condition, normally inherited as an autosomal recessive trait, in which a variable clinical presentation correlates poorly with laboratory phenotype...
  26. Brinkman H, van Mourik J, Mertens K. Persistent factor VIII-dependent factor X activation on endothelial cells is independent of von Willebrand factor. Blood Coagul Fibrinolysis. 2008;19:190-6 pubmed publisher
    Endothelial cells are able to support the activation of coagulation factor X by activated factor IX in the presence of its cofactor, factor VIII...
  27. Qureshi S, Yang L, Yegneswaran S, Rezaie A. FRET studies with factor X mutants provide insight into the topography of the membrane-bound factor X/Xa. Biochem J. 2007;407:427-33 pubmed
    ..fluorescein dye in the active sites of Fl-FPR (fluorescein-D-Phe-Pro-Arg-chloromethane)-inhibited fXa (activated Factor Xa) and its N-terminal EGF deletion mutant (fXa-desEGF1), and the acceptor OR (octadecylrhodamine) dye incorporated ..
  28. Grundy J, Lavigne N, Hirama T, MacKenzie C, Pryzdial E. Binding of plasminogen and tissue plasminogen activator to plasmin-modulated factor X and factor Xa. Biochemistry. 2001;40:6293-302 pubmed
    ..laboratory has suggested that the fibrinolytic enzyme plasmin (Pn) inactivates coagulation factors X (FX) and Xa (FXa) in the presence of Ca(2+) and anionic phospholipid (aPL), producing fragments which bind plasminogen (Pg) and ..
  29. Zhang M, Li G, Zhang Y, Kang J. Quantitative analysis of antithrombin III binding site in low molecular weight heparins by exhausetive heparinases digestion and capillary electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1068-1069:78-83 pubmed publisher
    ..It was demonstrated that the CE method provides more precise data for assessing the anti-FXa activity than that of the biochemical assay method.
  30. Spangfort M, Ipsen H, Sparholt S, Aasmul Olsen S, Larsen M, Mørtz E, et al. Characterization of purified recombinant Bet v 1 with authentic N-terminus, cloned in fusion with maltose-binding protein. Protein Expr Purif. 1996;8:365-73 pubmed
    ..White Birch) has been cloned and expressed in Escherichia coli as a fusion with maltose-binding protein and a Factor Xa proteolytic cleavage site...
  31. Than H, Loh J, Sum C, Ng H. Clinical utility of anti-Xa monitoring and differential sensitivity of prothrombin time assays: an illustrated case report. J Clin Pathol. 2015;68:318-9 pubmed publisher
  32. Mendell J, Tachibana M, Shi M, Kunitada S. Effects of food on the pharmacokinetics of edoxaban, an oral direct factor Xa inhibitor, in healthy volunteers. J Clin Pharmacol. 2011;51:687-94 pubmed publisher
    ..Both Japanese and Caucasian volunteers demonstrated a modest but clinically insignificant food effect. It was concluded that edoxaban can be administered without regard to food. ..
  33. Bouchard B, Orfeo T, Keith H, Lavoie E, Gissel M, Fung M, et al. Microparticles Formed During Storage of Red Blood Cell Units Support Thrombin Generation. J Trauma Acute Care Surg. 2017;: pubmed publisher
    ..This study was performed to assess thrombin generation via the prothrombinase complex by washed RBCs and RBC-derived microparticles as a function of RBC unit age.
  34. Dadousis C, Pegolo S, Rosa G, Bittante G, Cecchinato A. Genome-wide association and pathway-based analysis using latent variables related to milk protein composition and cheesemaking traits in dairy cattle. J Dairy Sci. 2017;100:9085-9102 pubmed publisher
    ..F7β-κ-CN, F8αS2-CN, and F9αS1-CN-Ph) and 1 F was linked to the whey protein (F10α-LA); 1 F underlined the udder health status (F6Udder health)...
  35. Boileau C, Eme L, Brochier Armanet C, Janicki A, Zhang C, Latifi A. A eukaryotic-like sulfiredoxin involved in oxidative stress responses and in the reduction of the sulfinic form of 2-Cys peroxiredoxin in the cyanobacterium Anabaena PCC 7120. New Phytol. 2011;191:1108-18 pubmed publisher
    ..This is the first functional characterization of a Srx enzyme in a prokaryotic organism. ..
  36. Bisson A, Angoulvant D, Philippart R, Clementy N, Babuty D, Fauchier L. Non-Vitamin K Oral Anticoagulants for Stroke Prevention in Special Populations with Atrial Fibrillation. Adv Ther. 2017;34:1283-1290 pubmed publisher
    ..e., direct thrombin inhibitors or direct factor Xa inhibitors)...
  37. Haynes L, Bouchard B, Tracy P, Mann K. Prothrombin activation by platelet-associated prothrombinase proceeds through the prethrombin-2 pathway via a concerted mechanism. J Biol Chem. 2012;287:38647-55 pubmed publisher
    ..The main source of α-thrombin in vivo is the activation of prothrombin by the prothrombinase complex assembled on either an activated cell membrane or cell fragment, the most relevant of which is the ..
  38. Liang Q, Chen Q, Ding Q, Wu F, Wang X, Xi X, et al. Six novel missense mutations causing factor X deficiency and application of thrombin generation test. Thromb Res. 2013;131:554-9 pubmed publisher
    Inherited factor X (FX) deficiency is a rare hemorrhagic condition characterized by a variable clinical presentation weakly correlating with laboratory phenotype and genotype...
  39. Göbel K, Kraft P, Pankratz S, Gross C, Korsukewitz C, Kwiecien R, et al. Prothrombin and factor X are elevated in multiple sclerosis patients. Ann Neurol. 2016;80:946-951 pubmed publisher
    ..suffering from relapsing-remitting and secondary progressive MS had significantly higher prothrombin and factor X levels than healthy donors, whereas levels were unchanged in primary progressive MS and neuromyelitis optica ..
  40. Girolami A, Scarparo P, Scandellari R, Allemand E. Congenital factor X deficiencies with a defect only or predominantly in the extrinsic or in the intrinsic system: a critical evaluation. Am J Hematol. 2008;83:668-71 pubmed publisher
    Congenital Factor X deficiency is commonly classified as type I, in which there is a concomitant decrease of activity and antigen (CRM negative), and in type II, in which activity is low but antigen is normal or near normal (CRM positive)...
  41. Hathcock J, Rusinova E, Vaananen H, Nemerson Y. Lipid-bound factor Xa regulates tissue factor activity. Biochemistry. 2007;46:6134-40 pubmed
    The activation of coagulation factor X by tissue factor (TF) and coagulation factor VIIa (VIIa) on a phospholipid surface is thought to be the key step in the initiation of blood coagulation...
  42. Vossen C, Hasstedt S, Demers C, Rosendaal F, Bovill E. Linkage analysis for three coagulation factors clustering on chromosome 13q34: factor VII, factor X and protein Z. J Thromb Haemost. 2007;5:1325-7 pubmed
  43. dela Cruz R, Jairajpuri M, Bock S. Disruption of a tight cluster surrounding tyrosine 131 in the native conformation of antithrombin III activates it for factor Xa inhibition. J Biol Chem. 2006;281:31668-76 pubmed
    ..Rates of heparin-independent Y131L and Y131A factor Xa inhibition were 25 and 29 times faster than for the control and Y131F, suggesting that Tyr(131) ring ..
  44. Izaguirre G, Olson S. Residues Tyr253 and Glu255 in strand 3 of beta-sheet C of antithrombin are key determinants of an exosite made accessible by heparin activation to promote rapid inhibition of factors Xa and IXa. J Biol Chem. 2006;281:13424-32 pubmed
    ..new exosites in strand 3 of beta-sheet C, which promote the reaction of the inhibitor with the target proteases, factor Xa and factor IXa...
  45. Livingston J, Sutherland M, Friedman H, Pryzdial E. Herpes simplex virus type 1-encoded glycoprotein C contributes to direct coagulation factor X-virus binding. Biochem J. 2006;393:529-35 pubmed publisher
    ..recently to initiate blood coagulation by FVIIa (activated Factor VII)-dependent proteolytic activation of FX (Factor X)...
  46. Carlsson K, Freskgård P, Persson E, Carlsson U, Svensson M. Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitor. Eur J Biochem. 2003;270:2576-82 pubmed
    ..is inhibited by tissue factor pathway inhibitor (TFPI) in two steps: first TFPI is bound to the active site of factor Xa (FXa), and subsequently FXa-TFPI exerts feedback inhibition of TF-FVIIa...
  47. Salek Ardakani S, Stuart A, Arrand J, Lyons S, Arrand J, Mackett M. High level expression and purification of the Epstein-Barr virus encoded cytokine viral interleukin 10: efficient removal of endotoxin. Cytokine. 2002;17:1-13 pubmed
    ..Viral interleukin 10 (IL-10) was released from the fusion protein by cleavage with the proteolytic enzyme factor Xa. We show that vIL-10 will bind to heparin and use this property to purify vIL-10 from factor Xa cleaved products ..
  48. Reddy S, Zhou Z, Rao K, Scott J, Watzke H, High K, et al. Molecular characterization of human factor XSan Antonio. Blood. 1989;74:1486-90 pubmed
    ..all eight exons and sequences around the splice junctions, putative promoter, and polyadenylation sites of human factor X DNA from a patient with factor X deficiency. Two genetic changes in factor X have been observed in this patient...
  49. Yang L, Manithody C, Rezaie A. Functional role of O-linked and N-linked glycosylation sites present on the activation peptide of factor X. J Thromb Haemost. 2009;7:1696-702 pubmed publisher
    There are two O-linked and two N-linked glycosylation sites on the activation peptide of factor X (FX) involving residues Thr-17, Thr-29, Asn-39 and Asn-49...
  50. Küpper C, Kellert L, Tiedt S, Wollenweber F. [New oral anticoagulants (NOAC) in stroke treatment]. Fortschr Neurol Psychiatr. 2017;: pubmed publisher
    ..A specific antidote is commercially available for the direct thrombin inhibitor dabigatran only. For the factor Xa inhibitors, an antidote is being investigated in clinical trials...
  51. Nehaj F, Sokol J, Ivanková J, Mokáň M, Kovář F, Stasko J, et al. First Evidence: TRAP-Induced Platelet Aggregation Is Reduced in Patients Receiving Xabans. Clin Appl Thromb Hemost. 2017;:1076029617734310 pubmed publisher
    ..Rivaroxaban and apixaban are 2 direct oral anticoagulants whose target specificity is activated factor X (FXa). However, it is still not fully understood if and how xabans impact platelet function...
  52. Rosano G, Spoletini I, Gianni W, Vitale C. New Advances In Atrial Fibrillation Management: The Role Of Apixaban. Curr Drug Targets. 2017;: pubmed publisher
    ..Among the NOACs, apixaban - a very specific antagonist of activated factor Xa - has pharmacokinetic and pharmacodynamic properties that allow significant efficacy in AF management...
  53. Wu C, Chaudhary K, Na Y, Welch D, Black P, Sonabend A, et al. Quality Assessment of Stereotactic Radiosurgery of a Melanoma Brain Metastases Model Using a Mouselike Phantom and the Small Animal Radiation Research Platform. Int J Radiat Oncol Biol Phys. 2017;99:191-201 pubmed publisher
    ..C57B6 mice underwent intracranial injection of B16-F10 melanoma cells. T1-weighted postcontrast magnetic resonance imaging (MRI) was performed on day 11 after injection...
  54. Zhang Y, Yang H, Sun W, Wang J, Zhang B, Shen Y, et al. Ethanol extract of Ilex hainanensis Merr. exhibits anti-melanoma activity by induction of G1/S cell-cycle arrest and apoptosis. Chin J Integr Med. 2018;24:47-55 pubmed publisher
    ..Caspases-3, -8, and -9 activities were detected using the colorimetric method. In addition, a B16-F10 melanoma xenograft mouse model was used to evaluate the anti-cancer activity of IME in vivo...
  55. Intagliata N, Henry Z, Maitland H, Shah N, Argo C, Northup P, et al. Direct Oral Anticoagulants in Cirrhosis Patients Pose Similar Risks of Bleeding When Compared to Traditional Anticoagulation. Dig Dis Sci. 2016;61:1721-7 pubmed publisher
    ..The aim of this study was to compare rates of bleeding in cirrhosis patients treated with DOAC (factor Xa inhibitors: rivaroxaban and apixaban) to those in cirrhosis patients treated with traditional anticoagulation (..
  56. Thorup S, Husted S, Vang M. [Monitoring options and reversal agents for oral anticoagulants]. Ugeskr Laeger. 2014;176: pubmed
    The approval of the oral direct thrombin inhibitor dabigatranetexilat and the oral factor Xa inhibitors rivaroxaban and apixaban as thromboprophylaxis challenges the position of the vitamin K antagonists (VKA)...
  57. Berny M, Munnix I, Auger J, Schols S, Cosemans J, Panizzi P, et al. Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear. PLoS ONE. 2010;5:e10415 pubmed publisher
    ..We sought to determine where activated factor X (FXa), (pro)thrombin, and fibrin(ogen) are localized in thrombi formed under venous shear...
  58. Yegneswaran S, Hackeng T, Dawson P, Griffin J. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa. J Biol Chem. 2008;283:33046-52 pubmed publisher
    To test the hypothesis that factor Xa (fXa) interacts with protein S, fXa was labeled active-site specifically with a dansyl (D) dye via a Glu-Gly-Arg (EGR) tether to yield DEGR-fXa(i)...
  59. Ananyeva N, Kouiavskaia D, Shima M, Saenko E. Intrinsic pathway of blood coagulation contributes to thrombogenicity of atherosclerotic plaque. Blood. 2002;99:4475-85 pubmed
    ..oxLDL) enhances their ability to support activity of 2 major complexes of the intrinsic pathway, Xase and prothrombinase, leading to a 20- and 10-fold increase in thrombin formation, respectively...
  60. Quinsey N, Whisstock J, Le Bonniec B, Louvain V, Bottomley S, Pike R. Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide. J Biol Chem. 2002;277:15971-8 pubmed
    ..H5) in high affinity heparin induces a conformational change in antithrombin that is particularly important for factor Xa (fXa) inhibition...
  61. Hagihara Y, Enjyoji K, Omasa T, Katakura Y, Suga K, Igarashi M, et al. Structure and function of the recombinant fifth domain of human beta 2-glycoprotein I: effects of specific cleavage between Lys77 and Thr78. J Biochem. 1997;121:128-37 pubmed
    ..We found that bovine factor Xa weakly but specifically cleaves the corresponding site of recombinant Domain V, i.e...
  62. Gale A, Yegneswaran S, Xu X, Pellequer J, Griffin J. Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site. J Biol Chem. 2007;282:21848-55 pubmed
    Prothrombin is proteolytically activated by the prothrombinase complex comprising the serine protease Factor (F) Xa complexed with its cofactor, FVa...