FGB

Summary

Gene Symbol: FGB
Description: fibrinogen beta chain
Alias: HEL-S-78p, fibrinogen beta chain, beta-fibrinogen, epididymis secretory sperm binding protein Li 78p, fibrinogen, B beta polypeptide
Species: human

Top Publications

  1. pmc Isolation and characterization of a neuropathogenic simian immunodeficiency virus derived from a sooty mangabey
    F J Novembre
    Divisions of Microbiology and Immunology, Yerkes Regional Primate Research Center, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Virol 72:8841-51. 1998
  2. doi Computerized axiography in TMD patients before and after therapy with 'function generating bites'
    M G Piancino
    Chair Department of Orthodontics and Gnathology Masticatory Function, University of Turin, Turin, Italy
    J Oral Rehabil 35:88-94. 2008
  3. doi Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study
    Cara L Carty
    Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, 1760 Minor Avenue, Seattle, WA 98101, USA
    Thromb Haemost 99:388-95. 2008
  4. doi Oncostatin M pathway plays a major role in the renal acute phase response
    Valerie A Luyckx
    HMRC 260, Univ of Alberta, Edmonton, Canada T6G 2S2
    Am J Physiol Renal Physiol 296:F875-83. 2009
  5. pmc Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3
    J Gao
    Department of Vascular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 16:6414-25. 1997
  6. ncbi The role of betagamma and alphagamma complexes in the assembly of human fibrinogen
    S Huang
    Department of Biochemistry, University of Washington, Seattle, Washington 98195 7350, USA
    J Biol Chem 271:27942-7. 1996
  7. ncbi Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion
    C M Redman
    Lindsley F Kimball Research Institute, New York Blood Center, 310 East 67 Street, New York, NY 10021, USA
    Ann N Y Acad Sci 936:480-95. 2001
  8. ncbi Mutation in the promoter region of the beta-fibrinogen gene and the risk of future myocardial infarction, stroke and venous thrombosis
    G J Blake
    The Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Eur Heart J 22:2262-6. 2001
  9. ncbi Fibrinogen gene promoter -455 A allele as a risk factor for lacunar stroke
    M Martiskainen
    Department of Forensic Medicine, University of Tampere, Finland
    Stroke 34:886-91. 2003
  10. ncbi Plasma fibrinogen concentration predicts the risk of myocardial infarction differently in various parts of Europe: effects of beta-fibrinogen genotype and environmental factors. The HIFMECH Study
    Maria Nastase Mannila
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska University Hospital, S 171 76 Stockholm, Sweden
    Thromb Haemost 92:1240-9. 2004

Research Grants

Detail Information

Publications213 found, 100 shown here

  1. pmc Isolation and characterization of a neuropathogenic simian immunodeficiency virus derived from a sooty mangabey
    F J Novembre
    Divisions of Microbiology and Immunology, Yerkes Regional Primate Research Center, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Virol 72:8841-51. 1998
    ..a simian immunodeficiency virus (SIV)- and simian T-cell lymphotropic virus-infected sooty mangabey (designated FGb) to rhesus and pig-tailed macaques resulted in the development of neurologic disease in addition to AIDS...
  2. doi Computerized axiography in TMD patients before and after therapy with 'function generating bites'
    M G Piancino
    Chair Department of Orthodontics and Gnathology Masticatory Function, University of Turin, Turin, Italy
    J Oral Rehabil 35:88-94. 2008
    ..disorders (TMD) before and after therapy with the functional appliances of the 'function generating bite' (FGB) type...
  3. doi Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study
    Cara L Carty
    Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, 1760 Minor Avenue, Seattle, WA 98101, USA
    Thromb Haemost 99:388-95. 2008
    ..We investigated whether common (> or = 5% minor allele frequency) variation in the fibrinogen genes (FGA, FGB, FGG) is associated with fibrinogen concentration, carotid artery intima-medial thickness (IMT) and risk of ..
  4. doi Oncostatin M pathway plays a major role in the renal acute phase response
    Valerie A Luyckx
    HMRC 260, Univ of Alberta, Edmonton, Canada T6G 2S2
    Am J Physiol Renal Physiol 296:F875-83. 2009
    ..OSM, OSMR, and fibrinogen beta (FGB) were progressively more highly expressed from prenephrectomy, living donor, deceased donor, to discarded donor ..
  5. pmc Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3
    J Gao
    Department of Vascular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 16:6414-25. 1997
    ..Furthermore, there are fundamental differences in the activation of Syk by alpha IIb beta 3 and immune response receptors, suggesting a unique role for integrins in Syk function...
  6. ncbi The role of betagamma and alphagamma complexes in the assembly of human fibrinogen
    S Huang
    Department of Biochemistry, University of Washington, Seattle, Washington 98195 7350, USA
    J Biol Chem 271:27942-7. 1996
    ..These data strongly support the role of alphagamma and betagamma complexes as functional intermediates in the assembly of fibrinogen...
  7. ncbi Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion
    C M Redman
    Lindsley F Kimball Research Institute, New York Blood Center, 310 East 67 Street, New York, NY 10021, USA
    Ann N Y Acad Sci 936:480-95. 2001
    ..In HepG2 cells, a feedback mechanism exists and extracellular sterols specifically downregulate expression of the three fibrinogen genes. These studies link, at the cellular level, basal fibrinogen expression with lipid metabolism...
  8. ncbi Mutation in the promoter region of the beta-fibrinogen gene and the risk of future myocardial infarction, stroke and venous thrombosis
    G J Blake
    The Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Eur Heart J 22:2262-6. 2001
    ..We investigated whether the distribution of the C148T polymorphism is associated with an increase in cardiovascular risk...
  9. ncbi Fibrinogen gene promoter -455 A allele as a risk factor for lacunar stroke
    M Martiskainen
    Department of Forensic Medicine, University of Tampere, Finland
    Stroke 34:886-91. 2003
    ..Carriers of the A allele of the fibrinogen -455G/A polymorphism have increased plasma fibrinogen levels. We studied the association of this polymorphism with stroke subtype in the Stroke Aging Memory (SAM) cohort...
  10. ncbi Plasma fibrinogen concentration predicts the risk of myocardial infarction differently in various parts of Europe: effects of beta-fibrinogen genotype and environmental factors. The HIFMECH Study
    Maria Nastase Mannila
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska University Hospital, S 171 76 Stockholm, Sweden
    Thromb Haemost 92:1240-9. 2004
    ..7%). Thus, plasma fibrinogen concentration contributes differently to MI across Europe, and a disease-related stimulus is required to evoke allele-specific regulation of fibrinogen synthesis...
  11. ncbi Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction
    Maria Nastase Mannila
    Atherosclerosis Research Unit, Karolinska Institutet, King Gustaf V Research Institute, Karolinska University Hospital, Solna, Stockholm, Sweden
    Thromb Haemost 93:570-7. 2005
    ..Candidate regions in the fibrinogen gamma (FGG), alpha (FGA) and beta (FGB) genes were screened for single nucleotide polymorphisms (SNPs)...
  12. ncbi Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen gamma' levels
    Shirley Uitte de Willige
    Hemostasis and Thrombosis Research Center, Department of Hematology C2 R, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Blood 106:4176-83. 2005
    We investigated the association between haplotypes of fibrinogen alpha (FGA), beta (FGB), and gamma (FGG), total fibrinogen levels, fibrinogen gamma' (gammaA/gamma' plus gamma'/gamma') levels, and risk for deep venous thrombosis...
  13. ncbi Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction
    Maria Nastase Mannila
    King Gustaf V Research Institute, Karolinska University Hospital Solna, S 171 76 Stockholm, Sweden
    Thromb Haemost 95:420-7. 2006
    An intricate interplay between the genes encoding fibrinogen gamma (FGG), alpha (FGA) and beta (FGB), coagulation factor XIII (F13A1) and interleukin 6 (IL6) and environmental factors is likely to influence plasma fibrinogen ..
  14. ncbi Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    A P Reiner
    Departments of Epidemiology and Genome Sciences, University of Washington, Seattle, WA 98101 1448, USA
    J Thromb Haemost 4:1279-87. 2006
    Previous genotype-phenotype association studies of fibrinogen have been limited by incomplete knowledge of genomic sequence variation within and between major ethnic groups in FGB, FGA, and FGG.
  15. doi Fibrinogen genes and myocardial infarction: a haplotype analysis
    Werner Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik, Klinikum rechts der Isar, Munich, Germany
    Arterioscler Thromb Vasc Biol 28:758-63. 2008
    ..We examined the association of haplotypes in the 50-kb fibrinogen gene region with myocardial infarction in 2 large case-control samples...
  16. doi Meta-analysis of genetic studies from journals published in China of ischemic stroke in the Han Chinese population
    Xiaowei Xu
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    Cerebrovasc Dis 26:48-62. 2008
    ..The aim of this study was to confirm the nature and number of genes contributing to stroke risk and qualify the genetic risk of each susceptibility gene in the Han Chinese population...
  17. doi Common genetic polymorphisms and haplotypes of fibrinogen alpha, beta, and gamma chains affect fibrinogen levels and the response to proinflammatory stimulation in myocardial infarction survivors: the AIRGENE study
    Benedicte Jacquemin
    Centre for Environmental Research, Municipal Institute of Medical Research, Barcelona, Spain
    J Am Coll Cardiol 52:941-52. 2008
    ..nucleotide polymorphisms (SNPs) and haplotypes of the fibrinogen gene-cluster (fibrinogen chains alpha [FGA], beta [FGB], and gamma [FGG]) could explain the inter- and intraindividual variability of fibrinogen levels in patients with ..
  18. doi Fibrinogen genes modify the fibrinogen response to ambient particulate matter
    Annette Peters
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Ingolstaedter Landstrasse, Neuherberg 85764, Germany
    Am J Respir Crit Care Med 179:484-91. 2009
    ..Ambient particulate matter has been associated with systemic inflammation indicated by blood markers such as fibrinogen, implicated in promoting atherothrombosis...
  19. doi G-455A polymorphism of beta-fibrinogen gene and the risk of premature myocardial infarction in Greece
    Loukianos S Rallidis
    Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Greece
    Thromb Res 125:34-7. 2010
    ..We examined whether the G-455A polymorphism of beta-fibrinogen gene is associated with the development of MI< or =35 years of age...
  20. ncbi Association between -455G/A and fibrinogen in a Chinese population
    Aijun Sun
    Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China
    Acta Cardiol 64:357-61. 2009
    ..The aim of the study was to evaluate the association between beta-fibrinogen gene -455G/A polymorphism and the plasma fibrinogen level in Chinese patients with different subtypes of coronary heart disease (CHD)...
  21. pmc Higher fibrinogen levels predict progression of coronary artery calcification in adults with type 1 diabetes
    T C Rodrigues
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Sciences Center, Aurora CO 80045, USA
    Atherosclerosis 210:671-3. 2010
    ..To determine whether fibrinogen levels predict independently progression of coronary artery calcification (CAC) in adults with type 1 diabetes...
  22. ncbi Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways
    S J Shattil
    Department of Vascular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Thromb Haemost 82:318-25. 1999
  23. ncbi Ethnic differences in fibrinogen levels: the role of environmental factors and the beta-fibrinogen gene
    D G Cook
    Department of Public Health Sciences, St George s Hospital Medical School, London
    Am J Epidemiol 153:799-806. 2001
    ..14 g/liter (95% CI: 0.02, 0.26 g/liter) in women and 0.15 g/liter (95% CI: 0.03, 0.27 g/liter) in men. Low fibrinogen levels in Blacks may partly explain their lower risk of ischemic heart disease in the United KINGDOM:..
  24. ncbi A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism
    Maartje Verschuur
    Hemostasis and Thrombosis Research Center, Department of Hematology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, Gaubius Laboratory, TNO Quality of Life, P O Box 2215, 2301 CE Leiden, The Netherlands
    J Biol Chem 280:16763-71. 2005
    ....
  25. doi Manipulating the quality control pathway in transfected cells: low temperature allows rescue of secretion-defective fibrinogen mutants
    Dung Vu
    Department of Genetic Medicine and Development, University Medical Center, Geneva, Switzerland
    Haematologica 93:224-31. 2008
    ..Bbeta and gamma. The disease is caused by mutations in one of the three fibrinogen-encoding genes, FGA, FGB and FGG. Among these, several mutations have been reported to specifically impair fibrinogen secretion...
  26. doi Regulation of fibrinogen production by microRNAs
    Alexandre Fort
    Department of Genetic Medicine and Development, University of Geneva Faculty of Medicine, Geneva, Switzerland
    Blood 116:2608-15. 2010
    ..Overexpression of hsa-miR-29 members led to decreased steady-state levels of all fibrinogen gene (FGA, FGB, and FGG) transcripts in HuH7 cells...
  27. ncbi Expression and analysis of a split premature termination codon in FGG responsible for congenital afibrinogenemia: escape from RNA surveillance mechanisms in transfected cells
    Marguerite Neerman-Arbez
    Department of Genetic Medicine and Development, University Medical School, Geneva, Switzerland
    Blood 104:3618-23. 2004
    ..The disease is caused by mutations in 1 of the 3 fibrinogen genes FGG, FGA, and FGB, clustered on the long arm of human chromosome 4...
  28. doi A novel frameshift mutation in FGA accounting for congenital afibrinogenemia predicted to encode an aberrant peptide terminating 158 amino acids downstream
    H Robert-Ebadi
    Division of Angiology and Hemostasis, University Hospital, Geneva, Switzerland
    Blood Coagul Fibrinolysis 20:385-7. 2009
    ..genes, most of them in the fibrinogen A alpha-chain gene (FGA), but also in the fibrinogen B beta-chain gene (FGB) and the fibrinogen gamma-chain gene (FGG). We report here a novel frameshift mutation (p...
  29. ncbi Molecular characterization of the first missense mutation in the fibrinogen Aalpha-chain gene identified in a compound heterozygous afibrinogenemic patient
    Manuela Platè
    Department of Biology and Genetics for Medical Sciences, University of Milan, Milan, Italy
    Biochim Biophys Acta 1772:781-7. 2007
    ..autosomal recessive trait and is invariantly associated with mutations affecting 1 of the 3 fibrinogen genes (FGA, FGB, and FGG, coding for Aalpha, Bbeta, and gamma chain, respectively)...
  30. ncbi Molecular mechanisms accounting for fibrinogen deficiency: from large deletions to intracellular retention of misfolded proteins
    D Vu
    Department of Genetic Medicine and Development, University Medical School, Geneva, Switzerland
    J Thromb Haemost 5:125-31. 2007
    ..Each polypeptide is encoded by a distinct gene, FGA, FGB and FGG, all three clustered in a region of 50 kb on 4q32...
  31. ncbi Recurrence of the 'deep-intronic' FGG IVS6-320A>T mutation causing quantitative fibrinogen deficiency in the Italian population of Veneto
    Manuela Platè
    Department of Biology and Genetics for Medical Sciences, University of Milan, Milan, Italy
    Blood Coagul Fibrinolysis 20:381-4. 2009
    ..low levels of fibrinogen in plasma, generally due to mutations in one of the three fibrinogen genes: FGA, FGB, and FGG, coding for A alpha, B beta, and gamma chain, respectively...
  32. ncbi Fibrinogen gene mutations accounting for congenital afibrinogenemia
    M Neerman-Arbez
    Division of Medical Genetics, University Medical School, Geneva, Switzerland
    Ann N Y Acad Sci 936:496-508. 2001
    ..Other studies identified one further FGA nonsense mutation, two FGB missense mutations, and one FGG nonsense mutation, all in homozygosity in a single patient...
  33. ncbi Mutational screening of six afibrinogenemic patients: identification and characterization of four novel molecular defects
    Luca Monaldini
    Department of Biology and Genetics for Medical Sciences, University of Milan, Via Viotti, Milan, Italy
    Thromb Haemost 97:546-51. 2007
    ..1:1,000,000) and is invariantly associated with mutations affecting one of the three fibrinogen genes (FGA, FGB, and FGG, coding for Aalpha, Bbeta, and gamma chain, respectively)...
  34. doi Rare inherited disorders of fibrinogen
    S S Acharya
    Department of Pediatrics, Weill Medical College of Cornell University, New York, NY 10021, USA
    Haemophilia 14:1151-8. 2008
    Fibrinogen, a hexameric glycoprotein encoded by three genes - FGA, FGB, FGG - clustered on chromosome 4q is involved in the final steps of coagulation as a precursor of fibrin monomers required for the formation of the haemostatic plug...
  35. ncbi Mutations in the fibrinogen aalpha gene account for the majority of cases of congenital afibrinogenemia
    M Neerman-Arbez
    Division of Medical Genetics, University Medical School and University Hospital, Geneva, Switzerland
    Blood 96:149-52. 2000
    ..Consequently, 86% of afibrinogenemia alleles analyzed to date have truncating mutations of FGA, though mutations in all 3 fibrinogen genes, FGG, FGA, and FGB, might be predicted to cause congenital afibrinogenemia.
  36. ncbi Molecular analysis of the fibrinogen gene cluster in 16 patients with congenital afibrinogenemia: novel truncating mutations in the FGA and FGG genes
    M Neerman-Arbez
    Centre Medical Universitaire, Geneva, Switzerland
    Hum Genet 108:237-40. 2001
    ..unrelated patients with mutations in FGA, confirming the relative importance of this gene compared with FGG and FGB in the molecular aetiology of afibrinogenemia. Three other patients were homozygous for mutations in FGG...
  37. ncbi Molecular basis of fibrinogen deficiency
    Marguerite Neerman-Arbez
    Department of Genetic Medicine and Development, University Medical School and Division of Angiology and Haemostasis, University Hospital, Geneva, Switzerland
    Pathophysiol Haemost Thromb 35:187-98. 2006
    ..All are due to mutations in one of the three fibrinogen genes, FGA, FGB and FGG, which are clustered in a region of 50 kb on the long arm of human chromosome 4...
  38. doi Congenital hypofibrinogenemia: characterization of two missense mutations affecting fibrinogen assembly and secretion
    Manuela Platè
    Department of Biology and Genetics for Medical Sciences, University of Milan, Via Viotti, 3 5 20133 Milan, Italy
    Blood Cells Mol Dis 41:292-7. 2008
    ..levels of fibrinogen in plasma, generally due to heterozygous mutations in one of the three fibrinogen genes (FGA, FGB, and FGG, coding for Aalpha, Bbeta, and gamma chain, respectively)...
  39. ncbi [The effect of MyoD family proteins on muscular atrophy induced by brachial plexus injury in rats]
    Zhaohui Wu
    Department of Pathophysiology, Medical Center of Fudan University, Shanghai 200032, China
    Zhonghua Yi Xue Za Zhi 82:561-3. 2002
    ..To study the changes of MyoD/myogenin expression in atrophic muscle after injury of brachial plexus among rats and to explore the role of proteins of MyoD family in denervation-induced muscular atrophy...
  40. doi Protein-expression profiles in mouse blood-plasma following acute whole-body exposure to (137)Cs gamma rays
    Kanokporn Noy Rithidech
    Pathology Department, Stony Brook University, Stony Brook, New York 11794 8691, USA
    Int J Radiat Biol 85:432-47. 2009
    ..To compare the pattern of protein-expression profiles in blood-plasma after exposure of CBA/CaJ mice to 0 or 3 Gy of (137)Cs gamma rays...
  41. ncbi "Closing volume" during high-frequency ventilation in anesthetized dogs
    T Hachenberg
    Department of Anesthesiology and Intensive Care, Westfalische Wilhelms Universitat Munster, FRG
    Acta Anaesthesiol Scand 32:140-6. 1988
    ..Two different tests for CV were used: the foreign gas bolus (FGB) with helium as nonresident gas and the single breath nitrogen dilution technique (SBO2)...
  42. pmc Characterization of neutralizing epitopes within the major capsid protein of human papillomavirus type 33
    Stefanie D Roth
    Institute for Medical Microbiology, Johannes Gutenberg University 55101 Mainz, Germany
    Virol J 3:83. 2006
    ....
  43. ncbi Association of citrullinated proteins with synovial exosomes
    K Skriner
    Charite Universitatsmedizin Berlin, Humboldt University of Berlin, Germany
    Arthritis Rheum 54:3809-14. 2006
    ..The aim of this study was to identify the nature of synovial exosomes from patients with different rheumatic diseases and to examine their potential autoantigenic content, which may be involved in the induction of an autoimmune response...
  44. doi "Heparinization" and hyperfibrinogenolysis by wasp sting
    Cristina Lombardini
    Service of Intensive Care, Department of Anesthesiology, Pharmacology and Intensive Care, University Hospitals of Geneva, 1211 Geneva, Switzerland
    Am J Emerg Med 27:1176.e1-3. 2009
    ..This results in the removal of the thrombin cleavage site and of the critical polymerization site from the fibrinogen beta chain. Thrombin- initiated clot formation is therefore inhibited...
  45. pmc Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo
    Teruaki Nakatsuji
    Department of Medicine, Division of Dermatology, University of California, San Diego, CA, USA
    Proteomics 8:3406-15. 2008
    ..After P. acnes infection, four proteins including fibrinogen, alpha polypeptide, fibrinogen beta chain, S100A9, and serine protease inhibitor A3K showed altered concentrations in the mimicked acne ..
  46. ncbi An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees
    T J Kunicki
    Department of Molecular and Experimental Medicine, The Division of Experimental Hemostasis and Thrombosis, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Thromb Haemost 4:137-47. 2006
    ..01). The major haplotypes of seven other candidate genes, GP1BA, ITGA2B, ITGB3, GP6, VWF, FGB, and IL6, were not associated with bleeding severity...
  47. ncbi Cell type-specific differential induction of the human gamma-fibrinogen promoter by interleukin-6
    Hai Ou Duan
    Department of Medicine Hematology Oncology Division, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 281:12451-7. 2006
    ..response, interleukin-6 (IL-6) and glucocorticoids up-regulate expression of the three fibrinogen (FBG) genes (fga, fgb, and fgg) in liver and lung epithelium; however, little constitutive lung expression occurs...
  48. doi The action of MBL-associated serine protease 1 (MASP1) on factor XIII and fibrinogen
    Anders Krarup
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Biochim Biophys Acta 1784:1294-300. 2008
    ..Nevertheless, rMASP1 can drive the formation of cross-linked fibrinogen. Since MASP1 is activated on contact of MBL or the ficolins with microorganisms, fibrinogen and factor XIII may be involved in the elimination of invading pathogens...
  49. ncbi [Differentially expressed protein study on unstable angina blood-stasis syndrome by fluorescence labelling method]
    Hui Hui Zhao
    Beijing University of Chinese Medicine, Beijing 100029, China
    Guang Pu Xue Yu Guang Pu Fen Xi 29:1647-50. 2009
    ..Blood-stasis syndrome. Results show that fibrinogen beta chain, fibrinogen gamma chain, alpha1-antitrypsin, haptoglobin beta chain and haptoglobin alpha2 chain were ..
  50. ncbi [Molecular biology of haemostasis: fibrinogen, factor XIII]
    M Meyer
    Fachbereich Medizintechnik, Fachhochschule Jena, Carl Zeiss Promenade 2, 07745 Jena
    Hamostaseologie 24:108-15. 2004
    Genetic defects of fibrinogen are caused by a broad spectrum of mutations in one of the three structural genes FGA, FGB and FGG...
  51. ncbi Principal component analysis of vertical ground reaction force: a powerful method to discriminate normal and abnormal gait and assess treatment
    A M S Muniz
    Biomed Eng Program, Fed Univ of Rio de Janeiro
    Conf Proc IEEE Eng Med Biol Soc 1:2683-6. 2006
    ..group (CG) of 25 normal and a group (FG) of six patients with lower limb fractures, which was considered before (FGB) and after (FGA) a treadmill physiotherapeutic treatment...
  52. ncbi [Inherited dysfibrinogenemia caused by Arg16His mutation in alpha chain of fibrinogen.]
    Xiao juan Zhao
    Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou 215006, China
    Zhonghua Xue Ye Xue Za Zhi 31:154-6. 2010
    ..To analyze the phenotype and genotype of a family with inherited dysfibrinogenemia...
  53. ncbi Synteny mapping in the bovine: genes from human chromosome 4
    N Zhang
    Department of Veterinary Pathology, Texas A and M University, College Station 77843
    Genomics 14:131-6. 1992
    ..IL-2, FGB, FGG, and F11, which also reside on MMU3, were assigned to bovine syntenic group U23...
  54. ncbi Ex vivo shear bond strength of fibreglass reinforced aesthetic brackets
    V Crow
    Orthodontic Department, Royal London Hospital, London, UK
    Br J Orthod 22:325-30. 1995
    ..05). Ceramic brackets bonded with two-mix and no-mix composite demonstrated a 30 and a 10 percent enamel fracture rate, respectively. There were no enamel or bracket fractures in any of the FGB groups.
  55. doi Identification of immune responsible fibrinogen beta chain in the liver of large yellow croaker using a modified annealing control primer system
    F J Xie
    The Key Laboratory of Science and Technology for Aquaculture and Food Safety, Fisheries College, Jimei University, Xiamen, Fujian 361021, China
    Fish Shellfish Immunol 27:202-9. 2009
    ..One of the genes we identified encodes for a fibrinogen beta chain (FGB)...
  56. ncbi Liposome transduction into cells enhanced by haptotactic peptides (Haptides) homologous to fibrinogen C-termini
    Raphael Gorodetsky
    Laboratory of Radiobiology and Biotechnology, Sharett Institute of Oncology, Hadassah University Hospital, P O B 12000, Jerusalem 91120, Israel
    J Control Release 95:477-88. 2004
    Haptides are 19-21mer cell-binding peptides equivalent to sequences on the C-termini of fibrinogen beta chain (Cbeta), gamma chain (preCgamma) and the extended alphaE chain of fibrinogen (CalphaE)...
  57. ncbi Molecular genetics of quantitative fibrinogen disorders
    R Asselta
    Department of Biology and Genetics for Medical Sciences, University of Milan, Via Viotti, 3 5 20133 Milano, Italy
    Cardiovasc Hematol Agents Med Chem 5:163-73. 2007
    ..Three genes (FGA, FGB, and FGG) clustered on chromosome 4q31.3-4q32...
  58. ncbi Glycaemic and insulinaemic responses to mechanical or thermal processed barley in horses
    I Vervuert
    Institute for Animal Nutrition, Nutrition Diseases and Dietetics, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    J Anim Physiol Anim Nutr (Berl) 91:263-8. 2007
    ..Six horses were fed in random order: whole (WB), finely ground (FGB), steamed (SB), steam-flaked (SFB) and popped barley (PB)...
  59. ncbi Early treatment with "function generating bite" of a left unillateral posterior cross-bite: chewing pattern before and after therapy with FGB
    Maria Grazia Piancino
    University of Turin, School of Orthodontics, University of Turin
    Int J Orthod Milwaukee 18:33-8. 2007
    ..canine to the second deciduous molar, corrected with the functional appliance "Function Generating Bite" (FGB) is reported. The chewing cycles were recorded before and 6 months after correction...
  60. doi Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II
    Masashi Imanishi
    Chemistry Research Laboratories, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba shi, Ibaraki 305 8585, Japan
    J Med Chem 51:4002-20. 2008
    The left-hand side (LHS) and central part of our first generation biphenyl (FGB) series was modified to improve in vitro and in vivo beta3-AR potency without loss of oral bioavailability...
  61. pmc beta-Fibrinogen Gene -455 G/A Polymorphism in Korean Ischemic Stroke Patients
    Seung Han Lee
    Department of Neurology, Chonnam National University Medical School, Gwangju, Korea
    J Clin Neurol 4:17-22. 2008
    We investigated the relationship between the beta-fibrinogen gene (FGB) -455 G/A polymorphism and plasma fibrinogen levels in Korean ischemic stroke patients...
  62. doi In vitro transcription of compound heterozygous hypofibrinogenemia Matsumoto IX; first identification of FGB IVS6 deletion of 4 nucleotides and FGG IVS3-2A>G causing abnormal RNA splicing
    Fumiko Terasawa
    Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
    Clin Chim Acta 411:1325-9. 2010
    ..a case of hypofibrinogenemia Matsumoto IX (M IX) caused by a novel compound heterozygous mutation involving an FGB IVS6 deletion of 4 nucleotides (Delta4b) (three T, one G; between FGB IVS6-10 and -16) and FGG IVS3-2A/G, which are ..
  63. doi The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease
    Babak Bahadori
    State Clinic St Poelten, Department of Internal Medicine 2, St Poelten, Austria
    Thromb Res 126:350-2. 2010
    ..pairs of non-identical polypeptide chains, encoded by different genes (fibrinogen alpha [FGA], fibrinogen beta [FGB] and fibrinogen gamma [FGG])...
  64. pmc Sheep mast cell proteinase-1: characterization as a member of a new class of dual-specific ruminant chymases
    A D Pemberton
    Department of Veterinary Clinical Studies, Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, Scotland, U K
    Biochem J 321:665-70. 1997
    ..It is proposed that SMCP-1 and duodenase represent a new class of ruminant chymases with unusual dual specificities...
  65. doi Genetic polymorphisms for the study of multifactorial stroke
    A Bersano
    Dipartimento di Scienze Neurologiche, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Istituto di Ricerca e Cura a Carattere Scientifico IRCCS, Universita degli Studi di Milano, Milano, Italy
    Hum Mutat 29:776-95. 2008
    ..We evaluated a number of studies on several candidate genes (including F5, F2, FGA/FGB/FGG, F7, F13A1, vWF, F12, SERPINE1, ITGB3/PLA1/PLA2/ITGA2B, ITGA2, GP1BA, ACE, AGT, NOS3, APOE, LPL, PON1, PDE4D, ..
  66. doi A field synopsis and meta-analysis of genetic association studies in peripheral arterial disease: The CUMAGAS-PAD database
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly, Larissa, Greece
    Am J Epidemiol 170:1-11. 2009
    ..Twenty-three polymorphisms in 22 potential PAD candidate genes (F2, FGB, MTHFR, ITGB3, ACE, AGT, IL6, CCL2, ICAM1, SELE, MMP9, PPARG, MMP1, ADD1, P2RY12, LIPC, PLA2G7, SCARB1, MMP3, MTTP, ..
  67. doi Genetic aspects of ischemic stroke: coagulation, homocysteine, and lipoprotein metabolism as potential risk factors
    Sanja Stankovic
    Institute for Medical Biochemistry, University School of Pharmacy and Clinical Center of Serbia, Belgrade, Serbia
    Crit Rev Clin Lab Sci 47:72-123. 2010
    ..The candidate 'stroke risk' genes affecting haemostasis (F5, F2, FGA/FGB, F7, F13A1, vWF, F12, SERPINE1, ITGB3/ITGA2B, ITGA2, GP1BA, TPA, TAFI, THBD, PZ, ANX5), homocysteine metabolism (..
  68. ncbi Retinoids stimulate fibrinogen production both in vitro (hepatocytes) and in vivo. Induction requires activation of the retinoid X receptor
    E Nicodeme
    Laboratoires Glaxo, Centre de Recherches, ZA de Courtaboeuf, Les Ulis, France
    Arterioscler Thromb Vasc Biol 15:1660-7. 1995
    ..A comparable increase was observed for both de novo fibrinogen synthesis and fibrinogen beta chain mRNA level...
  69. ncbi The mitogenic effects of the B beta chain of fibrinogen are mediated through cell surface calreticulin
    A J Gray
    University College London Medical School, Division of Cardiopulmonary Biochemistry, United Kingdom
    J Biol Chem 270:26602-6. 1995
    ..The present study has shown that cell surface calreticulin binds to the B beta chain of fibrinogen mediating its mitogenic activity...
  70. ncbi Molecular mechanisms of hypo- and afibrinogenemia
    S O Brennan
    Molecular Pathology Laboratory, Canterbury Health Laboratories, Christchurch Hospital, P O Box 151, Christchurch, New Zealand
    Ann N Y Acad Sci 936:91-100. 2001
    ....
  71. pmc Fibrinogen genotypes (alpha and beta) are associated with plasma fibrinogen levels in Chinese
    Y Liu
    J Med Genet 38:E31. 2001
  72. ncbi Selective pressure has not acted against hypercoagulability alleles in high-altitude Amerindians
    J L Rupert
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, B C, Canada
    Ann Hum Genet 67:426-32. 2003
    ..Alleles of the beta-fibrinogen gene (FGB) associated with lower fibrinogen levels are more common in highland Amerindians (Quechua) than lowland Amerindians ..
  73. ncbi Quality control of fibrinogen secretion in the molecular pathogenesis of congenital afibrinogenemia
    Dung Vu
    Department of Genetic Medicine and Development, Swiss Institute of Bioinformatics, University Medical Centre, Geneva, Switzerland
    Hum Mol Genet 14:3271-80. 2005
    ..Each polypeptide is encoded by a distinct gene, FGA, FGB and FGG, all three clustered in a region of 50 kb on 4q31...
  74. ncbi Identification of three FGA mutations in two Chinese families with congenital afibrinogenaemia
    Y Fang
    Division of Thrombosis and Hemostasis, Shanghai Institute of Hematology, Ruijin Hospital, Medical College of Shanghai Jiao Tong University, Shanghai, China
    Haemophilia 12:615-20. 2006
    ..All the exons, exon-intron boundaries and promoter regions of three Fg genes (FGA, FGB and FGG) were screened by direct sequencing...
  75. ncbi AMI is associated with polymorphisms in the NOS3 and FGB but not in PAI-1 genes in young adults
    Marcelo Ferraz Sampaio
    Instituto Dante Pazzanese de Cardiologia, Sao Paulo, SP, Brazil
    Clin Chim Acta 377:154-62. 2007
    We investigated the relationship between NOS3, FGB and PAI-1 polymorphisms and endothelial dysfunction and risk factors for acute myocardial infarction (AMI) in young adults.
  76. ncbi [Association of fibrinogen B beta -1420G/A, -993C/T and -854G/A gene polymorphism with coronary heart disease]
    Hong yun Xing
    Department of Hematology, Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan, 646000, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:622-6. 2006
    To analyze the frequency of FGB gene -1420G/A, -993C/T and -854G/A polymorphisms, and their association with plasma fibrinogen levels in patients with coronary heart disease and in health adults.
  77. ncbi Pseudo-exon activation caused by a deep-intronic mutation in the fibrinogen gamma-chain gene as a novel mechanism for congenital afibrinogenaemia
    Silvia Spena
    Department of Biology and Genetics for Medical Sciences, University of Milan, Milan, Italy
    Br J Haematol 139:128-32. 2007
    Congenital afibrinogenaemia, characterized by severe fibrinogen deficiency, is caused by mutations within FGA, FGB or FGG...
  78. doi Fibrinogen, COPD and mortality in a nationally representative U.S. cohort
    David M Mannino
    Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, USA
    COPD 9:359-66. 2012
    ..Fibrinogen is a marker of systemic inflammation and may represent an important biomarker for the progression of chronic obstructive pulmonary disease (COPD)...
  79. ncbi The β-fibrinogen -455G/A gene polymorphism and the risk of ischaemic stroke in a Polish population
    Aleksandra Golenia
    Department of Neurology, Jagiellonian University Medical College, ul Botaniczna 3, 31 503 Krakow, Poland
    Neurol Neurochir Pol 47:152-6. 2013
    ..In the present study, we assessed the significance of the β-fibrinogen -455G/A gene polymorphism and the risk of ischaemic stroke in a Polish population...
  80. ncbi Deep bite: a case report with chewing pattern and electromyographic activity before and after therapy with function generating bite
    M G Piancino
    Orthodontic Division Dental School Dept Surgical Sciences University of Turin Italy
    Eur J Paediatr Dent 14:156-9. 2013
    ..The purpose of this case report is the concurrent evaluation of the masticatory pattern and the electromyographic activity, recorded during mastication, before and after therapy of deep bite malocclusion...
  81. ncbi Multilocus Characterization of a Woodrat (Genus Neotoma) Hybrid Zone
    Matthew R Mauldin
    From the Department of Biological Sciences, Texas Tech University, 2901 Main, Lubbock, TX 79409 3131 Mauldin, Baker, and Bradley the Department of Biology, University of Central Oklahoma, Edmond, OK Haynie the Research and Testing Laboratory of the South Plains, Lubbock, TX Hanson and the Museum of Texas Tech University, Lubbock, TX Baker and Bradley
    J Hered 105:466-476. 2014
    ..introns (intron 2 of the vertebrate alcohol dehydrogenase gene [Adh1-I2] and intron 7 of the beta-fibrinogen gene [Fgb-I7]) were used to develop a composite genotype for each individual and for detection of hybridization...
  82. pmc Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling
    Aiming Liu
    Medical School of Ningbo University, Ningbo 315211, China Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA Electronic address
    Chem Biol Interact 223:80-6. 2014
    ..the target genes of NF-κB, such as pro-inflammatory cytokine Il6 and Ccl2, and those of STAT3, such as Socs3, Fga, Fgb and Fgg. SSd also enhanced the expression of the anti-inflammatory cytokine Il10 mRNA...
  83. doi Non-enzymatic activation of prothrombin induced by interaction with fibrin β26-42 region
    Volodymyr O Chernyshenko
    Palladin Biochemistry Institute of NAS of Ukraine Kyiv, Protein Structure and Functions Department, Kyiv, Ukraine
    Acta Biochim Pol 62:517-22. 2015
    ..From the data obtained we can conclude that desAB fibrin binds to prothrombin through the Bβ26-42 amino acid residues and the formation of such a complex caused a non-enzymatic activation of prothrombin. ..
  84. doi Management of pregnancy in dysfibrinogenemia cases: a dilemma
    Rucha Patil
    National Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai, India
    Blood Coagul Fibrinolysis 28:91-93. 2017
    ..DNA sequence analysis revealed a novel homozygous insertion-deletion in exon 7 in FGB. Dysfibrinogenemia is very difficult to diagnose and even after diagnosis, the treatment varies with the patient's ..
  85. doi Proteomic profiling of lymphedema development in mouse model
    Joomin Lee
    Department of Food and Nutrition, College of Natural Science, Chosun University, Gwangju, Republic of Korea
    Cell Biochem Funct 34:317-25. 2016
    ..mCG21744, parkinson disease, serum amyloid P-component precursor, annexin A8, mKIAA0098 protein, and fibrinogen beta chain precursor were differentially upregulated in the lymphedema mice compared with the sham-operated group...
  86. ncbi [Genetics of blood coagulation in young stroke patients]
    Endre Pongrácz
    BM Központi Kórház es Intézményei, Neurológiai Osztály, 1071 Budapest, Városligeti fasor 9 13
    Ideggyogy Sz 55:111-7. 2002
    ..In this genetico-epidemiological study the author's aim was to analyse the tendency of genetic polymorphisms to cluster in a cohort of young and elderly stroke patients and in healthy subjects in Hungary...
  87. ncbi Analysis of Iranian patients allowed the identification of the first truncating mutation in the fibrinogen Bbeta-chain gene causing afibrinogenemia
    Rosanna Asselta
    Department of Biology and Genetics for Medical Sciences, University of Milan, via Viotti 3 5, 20133 Milan, Italy
    Haematologica 87:855-9. 2002
    ..The aim of this work was to widen knowledge about the mutational spectrum of this disease by analyzing the molecular bases of congenital afibrinogenemia in three unrelated Iranian patients...
  88. ncbi Molecular variation at functional genes and the history of human populations--data on candidate genes for cardiovascular risk in the Mediterranean
    Pedro Moral
    Department of Animal Biology Anthropology, University of Barcelona, Barcelona, Spain
    Coll Antropol 27:523-36. 2003
    ....
  89. doi ORF3 protein of hepatitis E virus interacts with the Bbeta chain of fibrinogen resulting in decreased fibrinogen secretion from HuH-7 cells
    Ruchi Ratra
    Virology Group, International Centre for Genetic Engineering and Biotechnology, PO Box 10504, Aruna Asaf Ali Road, New Delhi 110067, India
    J Gen Virol 90:1359-70. 2009
    ..This report adds one more biological function to, and advances our understanding of, the cellular role of the ORF3 protein of HEV. The possible implications of these findings in the virus life cycle are discussed...
  90. doi Genetic risk factors for periodontitis in a Japanese population
    T Kobayashi
    General Dentistry and Clinical Education Unit, Niigata University Medical and Dental Hospital, 2 5274 Gakkocho dori, Chuo Ku, Niigata 951 8514, Japan
    J Dent Res 88:1137-41. 2009
    ..002). These results suggest that none of the polymorphisms tested was strongly associated with periodontitis in a Japanese population. However, the vitamin D receptor +1056 polymorphism may be related to chronic periodontitis...
  91. pmc Increased expression of matrix extracellular phosphoglycoprotein (MEPE) in cortical bone of the rat tibia after mechanical loading: identification by oligonucleotide microarray
    Christianne M A Reijnders
    Department of Internal Medicine, Endocrine Section, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 8:e79672. 2013
    ..The modulation of MEPE expression may indicate a connection between bone mineralization and bone formation after mechanical stimulation. ..
  92. pmc The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics
    Tara K Sigdel
    California Pacific Medical Center Research Institute, 475 Brannan St, Ste 220, San Francisco, California 9410
    Mol Cell Proteomics 13:621-31. 2014
    ..5) from all other transplant categories (HLA class II protein HLA-DRB1, KRT14, HIST1H4B, FGG, ACTB, FGB, FGA, KRT7, DPP4). Increased levels of three of these proteins, fibrinogen beta (FGB; p = 0...
  93. doi A central role for intermolecular dityrosine cross-linking of fibrinogen in high molecular weight advanced oxidation protein product (AOPP) formation
    Graziano Colombo
    Department of Biosciences, Universita degli Studi di Milano, Milan, Italy
    Biochim Biophys Acta 1850:1-12. 2015
    ..Here, we investigated the relative contribution of HSA and fibrinogen to generation of AOPPs...
  94. doi The role of fibrinogen as a predictor in preoperative chemoradiation for rectal cancer
    Jong Hoon Lee
    Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang si, Gyeonggi Do, Republic of Korea
    Ann Surg Oncol 22:209-15. 2015
    ..This study examined the association between plasma fibrinogen level before preoperative CRT and tumor response in advanced rectal cancer...
  95. ncbi Covalent structure of fibrinogen
    A Henschen
    Ann N Y Acad Sci 408:28-43. 1983
  96. ncbi Genes encoding fibrinogen and cardiovascular risk
    L Iacoviello
    Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Hypertension 38:1199-203. 2001
    ..In the future, gene-environment interactions should be considered in evaluating the relevance of genetic variations on the risk of cardiovascular disease...
  97. ncbi 2.8 A crystal structures of recombinant fibrinogen fragment D with and without two peptide ligands: GHRP binding to the "b" site disrupts its nearby calcium-binding site
    Michael S Kostelansky
    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Biochemistry 41:12124-32. 2002
    ..These structures provide a foundation for the detailed structural analysis of variant recombinant fibrinogens that were used to identify critical functional residues within fragment D...
  98. ncbi Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aalpha 9, Leu-->Pro)
    Michael Meyer
    Department of Medical Engineering, University of Applied Sciences FH Jena, Carl Zeiss Promenade 2, Jena D 07745, Germany
    Thromb Res 109:145-51. 2003
    ..Other amino acid exchanges within the fibrinopeptide A have been only rarely reported...

Research Grants13

  1. MOLECULAR BIOLOGY OF COLLAGEN RECEPTORS
    Thomas Kunicki; Fiscal Year: 2004
    ..The successful completion of the proposed studies will lead to a substantial increase in our understanding of the genetics and physiology of the platelet collagen receptor, GPVI. ..
  2. Molecular Genetics of Integrin Collagen Receptors
    Thomas Kunicki; Fiscal Year: 2007
    ..From a clinical standpoint, these studies will also reveal the impact of these gene differences on risk for adverse events in bleeding disorders such as Von Willebrand Disease. ..
  3. Combination DNA and Attenuated Virus Vaccine for SIV
    Francis Novembre; Fiscal Year: 2002
    ..Additionally, these studies will allow a comparison to other DNA-based strategies currently being utilized at the Yerkes Center. ..
  4. ANNEXIN II & PLASMIN MEDIATED HIGH GRADE GLIOMA INVASION
    Suchitra Acharya; Fiscal Year: 2002
    ..Dr. Hajjar is also very accessible for individual weekly meetings when the need arises. T h i s environment will provide excellent training for a developing physician-researcher. ..
  5. Genetics of Neuropathogenic SIV Infection
    Francis Novembre; Fiscal Year: 2007
    ..Finally, we will investigate the evolution of the ability of these viruses to induce the production of neurotoxins in CNS derived cells. ..
  6. STRUCTURAL STUDIES ON FIBRINOGEN AND FIBRIN
    Russell Doolittle; Fiscal Year: 2003
    ..Combined with the full structures of the native molecules at high resolution, these results should dispel much of the mystery of fibrin formation. ..
  7. Characterization of the flexible portions of fibrinogen
    Russell Doolittle; Fiscal Year: 2007
    ..These studies are aimed at determining the degree of specificity involved in the assembly of fibrin units and protofibrils as well as the relative locations of the regions involved. ..
  8. Association of Thrombophilia and Inflammation with Post-Thrombotic Syndrome
    Mary Cushman; Fiscal Year: 2008
    ..Resultant disability is estimated at 2 million lost workdays/year and medical costs as $300 million yearly. Findings here can form the basis for development of new therapies to treat, and moreover prevent,PTS. ..
  9. Age-related inflammatory changes: The role of genes and body composition changes
    Yongmei Liu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. STRUCTURES OF COAGULATION COFACTORS
    STEPHEN EVERSE; Fiscal Year: 2003
    ..abstract_text> ..
  11. TRANSCRIPTION FACTOR NF-E2 IN ALPHA IIB BETA 3 SIGNALING
    SANFORD SHATTIL; Fiscal Year: 2004
    ..abstract_text> ..
  12. Chronic Thromboembolic Pulmonary Hypertension
    TIMOTHY MORRIS; Fiscal Year: 2006
    ..The fragments will be subjected to liquid chromatography-mass spectroscopy with data-dependent MS-2 data acquisition, followed by computer-assisted sequence analysis. ..
  13. Regulation of Outside-In Integrin Signaling in Platelets
    SANFORD SHATTIL; Fiscal Year: 2007
    ..Thus, this line of investigation may lead to identification of new anti-thrombotic drug targets and serve as a paradigm for integrin signaling in other blood cells. [unreadable] [unreadable] [unreadable]..