FGFR3

Summary

Gene Symbol: FGFR3
Description: fibroblast growth factor receptor 3
Alias: ACH, CD333, CEK2, HSFGFR3EX, JTK4, fibroblast growth factor receptor 3, FGFR-3, fibroblast growth factor receptor 3 variant 4, hydroxyaryl-protein kinase, tyrosine kinase JTK4
Species: human

Top Publications

  1. ncbi Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers
    J H Jang
    Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
    Cancer Res 61:3541-3. 2001
  2. doi Fibroblast growth factor receptor 3 mutation analysis on voided urine for surveillance of patients with low-grade non-muscle-invasive bladder cancer
    Tahlita C M Zuiverloon
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Cancer Res 16:3011-8. 2010
  3. pmc Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells
    Tao Ren
    Cancer Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China
    Cancer Sci 105:186-94. 2014
  4. pmc Clinical and radiographic features of a family with hypochondroplasia owing to a novel Asn540Ser mutation in the fibroblast growth factor receptor 3 gene
    G Mortier
    J Med Genet 37:220-4. 2000
  5. doi Hypochondroplasia and Acanthosis nigricans: a new syndrome due to the p.Lys650Thr mutation in the fibroblast growth factor receptor 3 gene?
    Lidia Castro-Feijoo
    Unidad de Endocrinologia Pediatrica, Crecimiento y Adolescencia, Departamento de Pediatria, Hospital Clínico Universitario y Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain
    Eur J Endocrinol 159:243-9. 2008
  6. doi Clinical and molecular diagnosis of the skeletal dysplasias associated with mutations in the gene encoding Fibroblast Growth Factor Receptor 3 (FGFR3) in Portugal
    M R Almeida
    GenoMed, Instituto de Medicina Molecular, Lisboa, Portugal
    Clin Genet 75:150-6. 2009
  7. pmc The extracellular domain of fibroblast growth factor receptor 3 inhibits ligand-independent dimerization
    Lirong Chen
    Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Sci Signal 3:ra86. 2010
  8. doi Molecular grade (FGFR3/MIB-1) and EORTC risk scores are predictive in primary non-muscle-invasive bladder cancer
    Bas W G van Rhijn
    Department of Urology, Erasmus MC, Rotterdam, The Netherlands
    Eur Urol 58:433-41. 2010
  9. doi FGFR3 mutational status and protein expression in patients with bladder cancer in a Jordanian population
    Khaldon Bodoor
    Department of Applied Biology, Jordan University of Science and Technology, Irbid, Jordan
    Cancer Epidemiol 34:724-32. 2010
  10. pmc Somatic mutation of fibroblast growth factor receptor-3 (FGFR3) defines a distinct morphological subtype of high-grade urothelial carcinoma
    Hikmat A Al-Ahmadie
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA
    J Pathol 224:270-9. 2011

Research Grants

  1. Fast calcium responses along arteriolar endothelium in vivo
    Pooneh Bagher; Fiscal Year: 2010
  2. Steven S Segal; Fiscal Year: 2016
  3. Mike T Lin; Fiscal Year: 2014
  4. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
  5. PETER NIGEL UNWIN; Fiscal Year: 2014
  6. Nicotinic Acetylcholine Receptor Structure, Thermal Motion and Gating
    Michaela Jansen; Fiscal Year: 2011
  7. KENNETH W GRASING; Fiscal Year: 2015
  8. James J Galligan; Fiscal Year: 2016
  9. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard K Gordon; Fiscal Year: 2010
  10. Regulation of conducted hyperpolarization in microvascular endothelial cell tubes
    ERIK JOSEF BEHRINGER; Fiscal Year: 2012

Detail Information

Publications314 found, 100 shown here

  1. ncbi Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers
    J H Jang
    Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
    Cancer Res 61:3541-3. 2001
    ..disorders of skeletal and cranial development have been linked to fibroblast growth factor receptor (FGFR) 2 and FGFR3. Here we report two identical mutations in FGFR2 that cause craniosynostosis syndromes, Crouzon, Apert, and ..
  2. doi Fibroblast growth factor receptor 3 mutation analysis on voided urine for surveillance of patients with low-grade non-muscle-invasive bladder cancer
    Tahlita C M Zuiverloon
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Cancer Res 16:3011-8. 2010
    Mutations in the fibroblast growth factor receptor 3 (FGFR3) have been found in 70% of the low-grade non-muscle-invasive bladder cancer (NMI-BC) tumors...
  3. pmc Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells
    Tao Ren
    Cancer Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China
    Cancer Sci 105:186-94. 2014
    ..Apurinic/apyrimidinic endonuclease 1 (APE1) and fibroblast growth factor 2 (FGF2) and its receptor 3 (FGFR3) signaling pathway plays an important role in the angiogenic process...
  4. pmc Clinical and radiographic features of a family with hypochondroplasia owing to a novel Asn540Ser mutation in the fibroblast growth factor receptor 3 gene
    G Mortier
    J Med Genet 37:220-4. 2000
  5. doi Hypochondroplasia and Acanthosis nigricans: a new syndrome due to the p.Lys650Thr mutation in the fibroblast growth factor receptor 3 gene?
    Lidia Castro-Feijoo
    Unidad de Endocrinologia Pediatrica, Crecimiento y Adolescencia, Departamento de Pediatria, Hospital Clínico Universitario y Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain
    Eur J Endocrinol 159:243-9. 2008
    ..dysplasia inherited in an autosomal dominant manner due, in most cases, to mutations in the fibroblast growth factor receptor 3 (FGFR3)...
  6. doi Clinical and molecular diagnosis of the skeletal dysplasias associated with mutations in the gene encoding Fibroblast Growth Factor Receptor 3 (FGFR3) in Portugal
    M R Almeida
    GenoMed, Instituto de Medicina Molecular, Lisboa, Portugal
    Clin Genet 75:150-6. 2009
    Mutations in the gene that encodes Fibroblast Growth Factor Receptor 3 (FGFR3) are associated with Achondroplasia (MIM 100800), Hypochondroplasia (MIM 146000), Muenke Syndrome (MIM 602849), Thanatophoric Dysplasia (MIM 187600, MIM 187601)..
  7. pmc The extracellular domain of fibroblast growth factor receptor 3 inhibits ligand-independent dimerization
    Lirong Chen
    Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Sci Signal 3:ra86. 2010
    ..resonance energy transfer (QI-FRET) to determine the contribution of the extracellular domain of fibroblast growth factor receptor 3 (FGFR3) to the dimerization of the receptor...
  8. doi Molecular grade (FGFR3/MIB-1) and EORTC risk scores are predictive in primary non-muscle-invasive bladder cancer
    Bas W G van Rhijn
    Department of Urology, Erasmus MC, Rotterdam, The Netherlands
    Eur Urol 58:433-41. 2010
    ..Molecular grade (mG) based on fibroblast growth factor receptor 3 (FGFR3) gene mutation status and MIB-1 expression was proposed as an alternative to pathologic ..
  9. doi FGFR3 mutational status and protein expression in patients with bladder cancer in a Jordanian population
    Khaldon Bodoor
    Department of Applied Biology, Jordan University of Science and Technology, Irbid, Jordan
    Cancer Epidemiol 34:724-32. 2010
    ..Recent studies have shown that activating mutations in FGFR3 are the most common findings in non-invasive low grade bladder tumors...
  10. pmc Somatic mutation of fibroblast growth factor receptor-3 (FGFR3) defines a distinct morphological subtype of high-grade urothelial carcinoma
    Hikmat A Al-Ahmadie
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA
    J Pathol 224:270-9. 2011
    b>FGFR3 mutations are common in low-grade urothelial carcinoma and represent a potential therapeutic target in this disease...
  11. ncbi The fibroblast growth factor receptor 3 gene (FGFR3) is assigned to human chromosome 4
    K Keegan
    Department of Microbiology, School of Medicine, State University of New York, Stony Brook 11794 8621
    Cytogenet Cell Genet 62:172-5. 1993
    ..Here we demonstrate, by using somatic cell hybrids, that the FGFR3 gene localizes to human chromosome 4, showing that it, too, resides on a chromosome distinct from those on which ..
  12. ncbi Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells
    M J Cross
    Department of Genetics, Rudbeck Laboratory, S 75185 Uppsala, Sweden
    J Cell Sci 113:643-51. 2000
    ..Furthermore, whilst tyrosine 766 was not required for a proliferative response, it was required for fibroblast growth factor receptor-1 mediated cytoskeletal reorganisation...
  13. ncbi Altered intracellular localization of fibroblast growth factor receptor 3 in human breast cancer
    C Zammit
    Department of Cancer Medicine, Imperial College School of Medicine, Hammersmith Hospital Campus, DuCane Road, London W12 0NN, UK
    J Pathol 194:27-34. 2001
    Immunohistochemical staining of human breast tissues, using an antibody against fibroblast growth factor receptor 3 [FGFR-3], showed differences in cellular distribution...
  14. ncbi Fibroblast growth factor receptor 3 lacking the Ig IIIb and transmembrane domains secreted from human squamous cell carcinoma DJM-1 binds to FGFs
    M Terada
    Department of Biotechnology, Faculty of Engineering, Kyoto Sangyo University, Kamigamo Motoyama, Kita ku, Kyoto 603 8555, Japan
    Mol Cell Biol Res Commun 4:365-73. 2001
    ..We identified that the transcript FGFR3DeltaTM, an alternatively spliced isoform of FGFR3 lacking exons encoding the C-terminal half of Ig III (IIIb) and transmembrane domains, is expressed in the human ..
  15. pmc Parathyroid hormone receptor type 1/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations
    Sarah Cormier
    Institut National de la Santé et de la Recherche Médicale U426, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    Am J Pathol 161:1325-35. 2002
    The fibroblast growth factor receptor type 3 (FGFR3) and Indian hedgehog (IHH)/parathyroid hormone (PTH)/PTH-related peptide receptor type 1 (PTHR1) systems are both essential regulators of endochondral ossification...
  16. ncbi Insulin-like growth factor-1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through phosphatidylinositol 3-kinase and MAPK
    Mio Koike
    Department of Pediatrics, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Bone Miner Res 18:2043-51. 2003
    An activated mutation in the FGFR3 gene causes ACH. To examine the effects of IGF-1, which is an important mediator of GH, on apoptosis, we analyzed a chondrogenic cell line expressing the FGFR3 mutants...
  17. ncbi Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma
    Suzanne Trudel
    Department of Medicine, Weill Medical College and Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA
    Blood 103:3521-8. 2004
    We have previously shown that dysregulation of fibroblast growth factor receptor 3 (FGFR3) by the t(4;14) translocation is a primary event in multiple myeloma (MM) and that activating mutations of FGFR3 are acquired in some cases...
  18. ncbi Accelerated proliferation of myeloma cells by interleukin-6 cooperating with fibroblast growth factor receptor 3-mediated signals
    Hideaki Ishikawa
    Laboratory of Cellular Signal Analysis, Department of Bio Signal Analysis, Applied Medical Engineering Science, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755 8505, Japan
    Oncogene 24:6328-32. 2005
    ..Ectopic expression of fibroblast growth factor receptor 3 (FGFR 3) associated with the chromosomal translocation, t(4;14)(p16...
  19. ncbi The achondroplasia mutation does not alter the dimerization energetics of the fibroblast growth factor receptor 3 transmembrane domain
    Min You
    Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Biochemistry 45:5551-6. 2006
    The Gly380 --> Arg mutation in the TM domain of fibroblast growth factor receptor 3 (FGFR3) of the RTK family is linked to achondroplasia, the most common form of human dwarfism...
  20. ncbi siRNA mediated knockdown of fibroblast growth factor receptors 1 or 3 inhibits FGF-induced anchorage-independent clonogenicity but does not affect MAPK activation
    Norman R Estes
    Biochemistry and Molecular Biology Department, Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35255, USA
    Oncol Rep 15:1407-16. 2006
    ..Using RNAi strategies we found that knockdown of either FGFR1 or FGFR3 leads to inhibition of FGF2- or FGF4-induced soft agar clonogenicity without affecting that induced by heregulin ..
  21. ncbi Preserved fertility in a non-mosaic Klinefelter patient with a mutation in the fibroblast growth factor receptor 3 gene: case report
    A Juul
    Department of Growth and Reproduction GR, Rigshospitalet Section 5064, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Hum Reprod 22:1907-11. 2007
    ..non-mosaic 47,XXY karyotype) who was heterozygous for the classical 1138G>A mutation in the fibroblast growth factor receptor 3 (FGFR3) gene, which is a gain-of-function mutation resulting in achondroplasia...
  22. pmc Fibroblast growth factor receptor-3 regulates Paneth cell lineage allocation and accrual of epithelial stem cells during murine intestinal development
    Alda Vidrich
    Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Gastrointest Liver Physiol 297:G168-78. 2009
    b>Fibroblast growth factor receptor 3 (FGFR-3) is expressed in the lower crypt epithelium, where stem cells of the intestine reside...
  23. doi Fibroblast growth factor receptor 3 mutation in voided urine is a useful diagnostic marker and significant indicator of tumor recurrence in non-muscle invasive bladder cancer
    Makito Miyake
    Oncogene Research Unit Cancer Prevention Unit, Tochigi Cancer Center Research Institute, 4 9 13 Yonan, Utsunomiya, Japan
    Cancer Sci 101:250-8. 2010
    ..A sensitive and quantitative assay using peptide nucleic acid-mediated real-time PCR was developed for detecting FGFR3 mutations in the urine samples and evaluated as a molecular marker for detecting intravesical recurrence of NMIBC ..
  24. pmc Chromosome 4p16.3 variant modify bladder cancer risk in a Chinese population
    Meilin Wang
    Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing 210029, China
    Carcinogenesis 32:872-5. 2011
    ..10-1.67), compared with the CC genotype. Furthermore, rs798766 was significantly associated with FGFR3 messenger RNA expression...
  25. doi Fibroblast growth factor receptor-3 in urothelial tumorigenesis
    Gopa Iyer
    Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Urol Oncol 31:303-11. 2013
    Fibroblast growth factor receptor-3 (FGFR3) is a receptor tyrosine kinase implicated in the tumorigenesis of multiple malignancies, including bladder and other urothelial cancers, multiple myeloma, and cervical cancer...
  26. pmc Reactivation of mitogen-activated protein kinase (MAPK) pathway by FGF receptor 3 (FGFR3)/Ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma
    Vipin Yadav
    Oncology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 287:28087-98. 2012
    ..Mechanistically, we found that the enhanced activation of fibroblast growth factor receptor 3 (FGFR3) is linked to Ras and MAPK activation, therefore conferring vemurafenib resistance...
  27. doi Fibroblast growth factor receptor 3 is highly expressed in rarely dividing human type A spermatogonia
    Kathrein von Kopylow
    Department of Andrology, University Hospital Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Histochem Cell Biol 138:759-72. 2012
    Human spermatogonia (Spg) and their fetal precursors express fibroblast growth factor receptor 3 (FGFR3)...
  28. ncbi Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas
    D Cappellen
    Laboratoire de Morphogenèse Cellulaire et Progression Tumorale, UMR 144, Centre National de la Recherche Scientifique, Institut Curie, Section de Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Genet 23:18-20. 1999
  29. ncbi Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders
    Bas W G van Rhijn
    Department of Pathology, Josephine Nefkens Institute, Erasmus University, 3000 DR Rotterdam, The Netherlands
    Eur J Hum Genet 10:819-24. 2002
    Activating mutations in the fibroblast growth factor receptor 3 (FGFR3) gene are responsible for several autosomal dominant craniosynostosis syndromes and chondrodysplasias i.e...
  30. ncbi Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling
    Tal Ben-Zvi
    Institute of Animal Science, The Volcani Center, Bet Dagan 50250, Israel
    J Cell Sci 119:380-7. 2006
    ..induces the expression of SOCS1 and SOCS3 mRNA, and that these proteins are constitutively associated with FGFR3, as demonstrated by co-immunoprecipitation studies...
  31. doi FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth
    Xiangnan Du
    Molecular Oncology, Cancer Signaling and Translational Oncology, Bioinformatics, and Pathology, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Res 72:5843-55. 2012
    b>Fibroblast growth factor receptor 3 (FGFR3) belongs to a family of receptor tyrosine kinases that control cell proliferation, differentiation, and survival...
  32. pmc Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: implications for therapeutic targeting
    Tiewei Cheng
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    PLoS ONE 8:e57284. 2013
    ..Here we used a novel inhibitor of FGFRs 1-3 and RNAi to determine the effects of inhibiting FGFR1 or FGFR3 in a panel of human BC cell lines...
  33. ncbi A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia
    G A Bellus
    Center for Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Genet 10:357-9. 1995
    ..3 (refs 5-7) and mutations in the fibroblast growth factor receptor 3 (FGFR3) gene have been identified in patients with the disorder...
  34. ncbi Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis
    E E Plowright
    Princess Margaret Hospital, Toronto, Ontario, Canada
    Blood 95:992-8. 2000
    ..translocation occurs in 25% of multiple myeloma (MM) and results in both the ectopic expression of fibroblast growth factor receptor 3 (FGFR3) from der4 and immunoglobulin heavy chain-MMSET hybrid messenger RNA transcripts from der14...
  35. ncbi Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation
    Monica Kong
    Department of Chemistry and Biochemistry, Center for Molecular Genetics, University of California San Diego, La Jolla, California 92093 0367, USA
    J Biol Chem 277:15962-70. 2002
    b>Fibroblast growth factor receptor 3 (FGFR3) influences a diverse array of biological processes, including cell growth, differentiation, and migration...
  36. ncbi The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation
    April N Meyer
    Department of Chemistry and Biochemistry, Center for Molecular Genetics, University of California San Diego, La Jolla, CA 92093 0367, USA
    J Biol Chem 279:28450-7. 2004
    Activating mutations within fibroblast growth factor receptor 3 (FGFR3), a receptor tyrosine kinase, are responsible for human skeletal dysplasias including achondroplasia and the neonatal lethal syndromes thanatophoric dysplasia types I ..
  37. ncbi The gene for achondroplasia maps to the telomeric region of chromosome 4p
    M Velinov
    Department of Pediatrics, University of Connecticut Health Center, Farmington 06030
    Nat Genet 6:314-7. 1994
    ..3), by family linkage studies using 14 pedigrees. A positive lod score of z = 3.35 with no recombinants was obtained with an intragenic marker for IDUA. This localization will facilitate the positional cloning of the disease gene...
  38. ncbi Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia
    F Rousseau
    Service de Genetique, INSERM U 393, CNRS ER 88, Institut Necker, Hopital des Enfants Malades, Paris, France
    Nature 371:252-4. 1994
    ..8); the genetic interval encompassing the disease gene contains a member of the fibroblast-growth-factor receptor (FGFR3) family which is expressed in articular chondrocytes...
  39. ncbi Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes
    G A Bellus
    Medical Genetics Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 14:174-6. 1996
    ..We report a recurrent single point mutation in the FGFR3 gene, located on chromosome 4p, in ten unrelated families with craniosynostosis syndromes...
  40. ncbi Prevalence of Pro250Arg mutation of fibroblast growth factor receptor 3 in coronal craniosynostosis
    D M Moloney
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Lancet 349:1059-62. 1997
    The C749G (Pro250Arg) mutation in the gene for fibroblast growth factor receptor 3 (FGFR3) has been found in patients with various types of craniosynostosis...
  41. pmc Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
    M Chesi
    Genetics Department, National Cancer Institute, Bethesda, Maryland 20889 5105, USA
    Nat Genet 16:260-4. 1997
    ..The chromosome-4 breakpoints are clustered in a 70-kb region centromeric to the fibroblast growth factor receptor 3 gene (FGFR3), the apparent dysregulated oncogene...
  42. pmc A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene
    P L Tavormina
    Department of Biological Chemistry, University of California, Irvine, CA, USA
    Am J Hum Genet 64:722-31. 1999
    We have identified a novel fibroblast growth factor receptor 3 (FGFR3) missense mutation in four unrelated individuals with skeletal dysplasia that approaches the severity observed in thanatophoric dysplasia type I (TD1)...
  43. ncbi Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma
    K Sibley
    ICRF Clinical Centre, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Oncogene 20:686-91. 2001
    ..One candidate within this region is fibroblast growth factor receptor 3 (FGFR3)...
  44. ncbi Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t(4;12)(p16;p13) chromosomal translocation
    F Yagasaki
    First Department of Internal Medicine, Saitama Medical School, Saitama, Japan
    Cancer Res 61:8371-4. 2001
    ..We identified a novel ETV6 partner gene, fibroblast growth factor receptor 3 (FGFR3), in a patient with peripheral T-cell lymphoma (PTCL) with a t(4;12)(p16;p13) translocation...
  45. ncbi Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs
    Shaun K Olsen
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 278:34226-36. 2003
    ..Hence, FHFs and FGFs bear striking structural similarity but have diverged to direct related surfaces toward interaction with distinct protein targets...
  46. pmc FGFR3IIIS: a novel soluble FGFR3 spliced variant that modulates growth is frequently expressed in tumour cells
    L M Sturla
    Candlelighter s Children s Cancer Research Laboratory, Cancer Research UK Clinical Centre, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Br J Cancer 89:1276-84. 2003
    b>Fibroblast growth factor receptor 3 (FGFR3) is one of four high-affinity tyrosine kinase receptors for the FGF family of ligands, frequently associated with growth arrest and induction of differentiation...
  47. ncbi FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder
    Ashraf A Bakkar
    Equipe mixte Inserm Institut National de la Santé et de la Recherche Médicale, and Service d Urologie, Paris, France
    Cancer Res 63:8108-12. 2003
    b>FGFR3 and TP53 mutations are frequent in superficial papillary and invasive disease, respectively...
  48. ncbi Fibroblast growth factor receptor 3 is overexpressed in urinary tract carcinomas and modulates the neoplastic cell growth
    J Javier Gómez-Román
    Departamento Anatomiá Patológica Servicio de Urología, Hospital Universitario Marques de Valdecilla, Servicio Cantabro de Salud, Facultad de Medicina, Universidad de Cantabria, Avenida de Valdecilla S N, E39008 Santander, Cantabria, Spain
    Clin Cancer Res 11:459-65. 2005
    b>Fibroblast growth factor receptor 3 (FGFR3) mutations have been associated with achondroplastic syndromes and urinary bladder carcinomas...
  49. ncbi Cell responses to FGFR3 signalling: growth, differentiation and apoptosis
    Corine G M L'Hôte
    Cancer Research UK Clinical Centre, St James s University Hospital, Beckett Street, Leeds LS9 7TF, UK
    Exp Cell Res 304:417-31. 2005
    b>FGFR3 is a receptor tyrosine kinase (RTK) of the FGF receptor family, known to have a negative regulatory effect on long bone growth...
  50. pmc Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi
    Christian Hafner
    Department of Dermatology, University of Regensburg, Germany
    J Clin Invest 116:2201-2207. 2006
    ..Germline mutations of the FGF receptor 3 (FGFR3) cause autosomal dominant skeletal disorders such as achondroplasia and thanatophoric dysplasia, which can be ..
  51. ncbi MIP-1alpha (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma
    Esther Masih-Khan
    Department of Medical Oncology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Blood 108:3465-71. 2006
    Overexpression of fibroblast growth factor receptor 3 (FGFR3) is a hallmark of t(4;14) multiple myeloma (MM)...
  52. ncbi PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors
    Elena Lopez-Knowles
    Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Carrer del Dr Aiguader 80, 08003 Barcelona, Spain
    Cancer Res 66:7401-4. 2006
    ..Bladder tumors constitute a very heterogeneous disease. Superficial tumors are characterized by a high prevalence of FGFR3 mutations and chromosome 9 alterations...
  53. ncbi FGFR3 intracellular mutations induce tyrosine phosphorylation in the Golgi and defective glycosylation
    Linda Gibbs
    INSERM U781, Hopital des Enfants Malades, 149 rue de Sévres 75015 Paris, France
    Biochim Biophys Acta 1773:502-12. 2007
    Mutations of the Fibroblast Growth Factor Receptor 3 (FGFR3) gene have been implicated in a series of skeletal dysplasias including hypochondroplasia, achondroplasia and thanatophoric dysplasia...
  54. ncbi The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor
    Jacky Bonaventure
    Institut Curie, Universite Paris Sud, Orsay, and Department of Medical Genetics INSERM U393, Hopital Necker, Paris, France
    FEBS J 274:3078-93. 2007
    Recurrent missense fibroblast growth factor receptor 3 (FGFR3) mutations have been ascribed to skeletal dysplasias of variable severity including the lethal neonatal thanatophoric dysplasia types I (TDI) and II (TDII)...
  55. doi FGFR3 and PIK3CA mutations are involved in the molecular pathogenesis of solar lentigo
    C Hafner
    Department of Dermatology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Br J Dermatol 160:546-51. 2009
    ..It has been proposed that SL may subsequently evolve into adenoid seborrhoeic keratosis (SK). However, little is known about the genetic basis of SL. In human SK, FGFR3 and PIK3CA mutations have recently been identified.
  56. pmc Tumour formation by single fibroblast growth factor receptor 3-positive rhabdomyosarcoma-initiating cells
    M Hirotsu
    Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Br J Cancer 101:2030-7. 2009
    ..The objective of this study was to identify and characterise a subpopulation of human sarcoma-initiating cells...
  57. pmc A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
    Lambertus A Kiemeney
    Department of Epidemiology, Biostatistics and Health Technology Assessment, Nijmegen, The Netherlands
    Nat Genet 42:415-9. 2010
    ..24, P = 9.9 x 10(-12)). rs798766 is located in an intron of TACC3, 70 kb from FGFR3, which often harbors activating somatic mutations in low-grade, noninvasive UBC...
  58. pmc FGFR3 heterodimerization in achondroplasia, the most common form of human dwarfism
    Lijuan He
    Department of Materials Science and Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Biol Chem 286:13272-81. 2011
    The G380R mutation in the transmembrane domain of fibroblast growth factor receptor 3 (FGFR3) causes achondroplasia, the most common form of human dwarfism...
  59. pmc Oncogenic FGFR3 gene fusions in bladder cancer
    Sarah V Williams
    Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds LS9 7TF, UK
    Hum Mol Genet 22:795-803. 2013
    FGF receptor 3 (FGFR3) is activated by mutation or over-expression in many bladder cancers. Here, we identify an additional mechanism of activation via chromosomal re-arrangement to generate constitutively activated fusion genes...
  60. pmc Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3
    K Keegan
    Department of Microbiology, State University of New York, Stony Brook 11794
    Proc Natl Acad Sci U S A 88:1095-9. 1991
    ..These data establish the existence of an additional member of the FGFR family that we have named FGFR-3...
  61. ncbi Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans
    G A Meyers
    Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 3914, USA
    Nat Genet 11:462-4. 1995
    ..In contrast, only FGFR3 mutations have been reported in dwarfing conditions--achondroplasia, thanatophoric dysplasia, and ..
  62. ncbi The choice between alternative IIIb and IIIc exons of the FGFR-3 gene is not strictly tissue-specific
    E Scotet
    INSERM U 211, Institut de Biologie, Nantes, France
    Biochim Biophys Acta 1264:238-42. 1995
    ..This is in contrast with the strictly exclusive alternative choice between IIIb or IIIc exons of the FGFR-2 gene: epithelial cells make only the IIIb choice while fibroblastic cells make only the IIIc choice...
  63. ncbi Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3
    P L Tavormina
    Department of Biological Chemistry and Human Genome Research Center, University of California, Irvine 92717, USA
    Nat Genet 9:321-8. 1995
    ..Mutations causing achondroplasia are in FGFR3, suggesting that mutations in this gene may cause TD...
  64. ncbi Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia
    R Shiang
    Department of Biological Chemistry, College of Medicine, University of California, Irvine 92717
    Cell 78:335-42. 1994
    ..3 by linkage analyses. The ACH candidate region includes the gene encoding fibroblast growth factor receptor 3 (FGFR3), which was originally considered as a candidate for the Huntington's disease gene...
  65. ncbi Identification of a novel variant form of fibroblast growth factor receptor 3 (FGFR3 IIIb) in human colonic epithelium
    B Murgue
    Gastrointestinal Unit, Massachusetts General Hospital, Boston 02114
    Cancer Res 54:5206-11. 1994
    ..This putative receptor was found to be identical to the human fibroblast growth factor receptor 3 (FGFR3) except for a region of 150 nucleotides (50 amino acids) encoding the presumptive ligand-..
  66. ncbi Fibroblast growth factor receptors (FGFRs) localize in different cellular compartments. A splice variant of FGFR-3 localizes to the nucleus
    C L Johnston
    Department of Medical Oncology, Charing Cross and Westminster Medical School, London, United Kingdom
    J Biol Chem 270:30643-50. 1995
    ..We conclude that two forms of FGFR-3 are present in breast epithelial cells; a full-length 135-kDa receptor, which has a conventional membrane localization, and a novel soluble form of 110 kDa...
  67. pmc Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia
    M K Webster
    Department of Chemistry and Biochemistry, University of California, San Diego, 92093 0322, USA
    EMBO J 15:520-7. 1996
    ..has recently been shown to result from a Gly to Arg substitution in the transmembrane domain of the fibroblast growth factor receptor 3 (FGFR3), although the molecular consequences of this mutation have not been investigated...
  68. ncbi Fibroblast growth factor receptor 3 is a negative regulator of bone growth
    C Deng
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Cell 84:911-21. 1996
    ..We have identified a role for fibroblast growth factor receptor 3 (FGFR-3) in this process by disrupting the murine Fgfr-3 gene to produce severe and progressive ..
  69. ncbi Receptor specificity of the fibroblast growth factor family
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:15292-7. 1996
    ..These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways...
  70. ncbi Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1)
    F Rousseau
    Unité de Recherches sur les Handicaps Génétiques de I Enfant INSERM U 393, CNRS ER 88, Paris, France
    Hum Mol Genet 5:509-12. 1996
    ..Mutations in the fibroblast growth factor receptor 3 (FGFR3) gene were identified in both subtypes...
  71. pmc A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome
    M Muenke
    Department of Pediatrics, University of Pennsylvania, Philadelphia, USA
    Am J Hum Genet 60:555-64. 1997
    ..is due to an amino acid substitution (Pro250Arg) that results from a single point mutation in the fibroblast growth factor receptor 3 gene on chromosome 4p...
  72. ncbi Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein
    M Kanai
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 272:6621-8. 1997
    Stimulation of fibroblast growth factor receptor 3 (FGFR3) results in a variety of functional effects, including regulation of epithelial cell growth and differentiation...
  73. ncbi Cytokine regulation of fibroblast growth factor receptor 3 IIIb in intestinal epithelial cells
    M Kanai
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Am J Physiol 272:G885-93. 1997
    ..the effects of growth factors and cytokines on the expression of the fibroblast growth factor (FGF) receptor 3 (FGFR3) IIIb expressed on intestinal epithelial cells were examined in Caco-2 cells...
  74. ncbi Clinical spectrum of fibroblast growth factor receptor mutations
    M R Passos-Bueno
    Departamento Biologia, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, Brazil
    Hum Mutat 14:115-25. 1999
    ..entities, are caused by mutations in one of three fibroblast growth factor receptor genes (FGFR1, FGFR2, and FGFR3)...
  75. ncbi Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4
    K C Hart
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093 0367, USA
    Oncogene 19:3309-20. 2000
    ..Mutation of Lys650-->Glu in the activation loop of the FGFR3 kinase domain causes the lethal human skeletal disorder thanatophoric dysplasia type II (TDII) and is also found ..
  76. pmc Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype
    G A Bellus
    Department of Dermatology, University of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Hum Genet 67:1411-21. 2000
    The fibroblast growth factor-receptor 3 (FGFR3) Lys650 codon is located within a critical region of the tyrosine kinase-domain activation loop...
  77. ncbi Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14)
    D Intini
    Servizio Ematologia, Dipartimento di Scienze Mediche, Universita di Milano, Ospedale Maggiore di Milano, IRCCS, Milano, Italy
    Br J Haematol 114:362-4. 2001
    The t(4;14)(p16.3;q32) in multiple myeloma (MM) leads to an apparent deregulation of the FGFR3 and WHSC1/MMSET genes...
  78. ncbi Syndrome of coronal craniosynostosis, Klippel-Feil anomaly, and sprengel shoulder with and without Pro250Arg mutation in the FGFR3 gene
    R B Lowry
    Department of Medical Genetics, Alberta Children s Hospital and University of Calgary, Calgary, Alberta, Canada
    Am J Med Genet 104:112-9. 2001
    A unique Pro250Arg point mutation in fibroblast growth factor receptor 3 (FGFR3) was initially reported by Bellus et al. [1996: Nat Genet 14:174-176] and the phenotype subsequently by Muenke et al...
  79. ncbi Differential activation of cysteine-substitution mutants of fibroblast growth factor receptor 3 is determined by cysteine localization
    Rivka Adar
    ProChon Biotech, Ltd, Kiryat Weizmann, Science Park, Rehovot, Israel
    J Bone Miner Res 17:860-8. 2002
    Various human skeletal disorders are thought to be caused by mutations in fibroblast growth factor receptor 3 (FGFR3). These result in chronic FGFR3 hyperactivation and inhibition of bone growth...
  80. ncbi FGF receptors ubiquitylation: dependence on tyrosine kinase activity and role in downregulation
    E Monsonego-Ornan
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    FEBS Lett 528:83-9. 2002
    ..Here we compared the ubiquitylation of either wild type or a K508A 'kinase-dead' mutant of fibroblast growth factor receptor 3 (FGFR3) with that of its naturally occurring overactive mutants, G380R as in achondroplasia, or ..
  81. ncbi The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum
    Patricia M J Lievens
    Department of Neurological Sciences, University of Verona Medical School, 37134 Verona, Italy
    J Biol Chem 278:17344-9. 2003
    The K650E substitution in the fibroblast growth factor receptor 3 (FGFR3) causes constitutive tyrosine kinase activity of the receptor and is associated to the lethal skeletal disorder, thanatophoric dysplasia type II (TDII)...
  82. pmc Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity
    Shaun K Olsen
    Departments of Pharmacology and Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 101:935-40. 2004
    ..Importantly, comparison of the three FGF1-FGFR structures shows that the flexibility of the betaC'-betaE loop is a major determinant of ligand-binding specificity and promiscuity...
  83. ncbi Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias
    L Legeai-Mallet
    Unite de Recherches sur les Handicaps Genetiques de l Enfant, INSERM U 393, Institut Necker, 75743, Paris15, France
    Bone 34:26-36. 2004
    ..TD) are human skeletal disorders of increasing severity accounted for by mutations in the fibroblast growth factor receptor 3 (FGFR3)...
  84. ncbi FGFR3 and P53 characterize alternative genetic pathways in the pathogenesis of urothelial cell carcinoma
    Bas W G van Rhijn
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    Cancer Res 64:1911-4. 2004
    b>Fibroblast growth factor receptor 3 (FGFR3) and P53 mutations are frequently observed in bladder cancer. We here describe the distribution of FGFR3 mutations and P53 overexpression in 260 primary urothelial cell carcinomas...
  85. ncbi Paternal origin of FGFR3 mutations in Muenke-type craniosynostosis
    Sahan V Rannan-Eliya
    NDCLS, Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe, Headington, Oxford, UK
    Hum Genet 115:200-7. 2004
    Muenke syndrome, also known as FGFR3-associated coronal synostosis, is defined molecularly by the presence of a heterozygous nucleotide transversion, c...
  86. ncbi The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling
    Patricia M J Lievens
    Division of Biochemistry, Department of Neurological Sciences, University of Verona Medical School, 37134 Verona, Italy
    J Biol Chem 279:43254-60. 2004
    Amino acid substitutions at the Lys-650 codon within the activation loop kinase domain of fibroblast growth factor receptor 3 (FGFR3) result in graded constitutive phosphorylation of the receptor...
  87. ncbi Reciprocal relationship in gene expression between FGFR1 and FGFR3: implication for tumorigenesis
    Jun Hyeog Jang
    Department of Biochemistry, Inha University College of Medicine, 7 241 Shinheung dong 3 ga, Jung Gu, Incheon 400 712, Korea
    Oncogene 24:945-8. 2005
    We have previously demonstrated that the expression of FGFR3 is frequently downregulated in colorectal carcinoma cells...
  88. ncbi FGFR3 and Tp53 mutations in T1G3 transitional bladder carcinomas: independent distribution and lack of association with prognosis
    Silvia Hernandez
    Universitat Pompeu Fabra, Institut Municipal d Investigacio Medica, Hospital del Mar, Barcelona, Spain
    Clin Cancer Res 11:5444-50. 2005
    b>FGFR3 and Tp53 mutations have been proposed as defining two alternative pathways in the pathogenesis of transitional bladder cancer. FGFR3 mutations are associated with low-grade tumors and a favorable prognosis...
  89. ncbi Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors
    Karsten Zieger
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University, Denmark
    Clin Cancer Res 11:7709-19. 2005
    ..Recent reports suggest activating mutations of the fibroblast growth factor receptor 3 (FGFR3) gene as marker for the "papillary" pathway with good prognosis, in contrast to the more ..
  90. ncbi A simple and fast method for the simultaneous detection of nine fibroblast growth factor receptor 3 mutations in bladder cancer and voided urine
    Johanna M M van Oers
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Clin Cancer Res 11:7743-8. 2005
    Mutations in the fibroblast growth factor receptor 3 (FGFR3) occur in 50% of primary bladder tumors...
  91. ncbi Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines
    Darren C Tomlinson
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, United Kingdom
    Cancer Res 65:10441-9. 2005
    ..b>FGFR3 was identified as the major family member expressed in both normal human urothelium and cultured normal human ..
  92. pmc FGFR3 dimer stabilization due to a single amino acid pathogenic mutation
    Edwin Li
    Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    J Mol Biol 356:600-12. 2006
    ..An example of a TM domain pathogenic mutation is the Ala391-->Glu mutation in fibroblast growth factor receptor 3 (FGFR3), linked to Crouzon syndrome with acanthosis nigricans, as well as to bladder cancer...
  93. ncbi FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancer
    P Mhawech-Fauceglia
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Elm and Carlton Street, Buffalo, NY 14263, USA
    Eur J Surg Oncol 32:231-7. 2006
    This study is designed to evaluate the expression and prognostic value of FGFR3 protein expression in patients with pTa/pT1 tumours and to determine the significance of the combinations of FGFR3 and p53 protein expressions in bladder ..
  94. ncbi The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells
    Suzanne Trudel
    University Health Network, Princess Margaret Hospital, McLaughlin Centre of Molecular Medicine, 620 University Avenue, Rm 8204, Toronto, Ontario, Canada M5G 2C1
    Blood 107:4039-46. 2006
    The association of fibroblast growth factor receptor 3 (FGFR3) expression with t(4;14) multiple myeloma (MM) and the demonstration of the transforming potential of this receptor tyrosine kinase (RTK) make it a particularly attractive ..
  95. ncbi Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q
    D Lindgren
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Oncogene 25:2685-96. 2006
    We used gene expression profiling, mutation analyses of FGFR3 and TP53, and LOH analyses of chromosome 9 and the TP53 region on chromosome arm 17p, to molecularly characterize 75 Ta and T1 bladder carcinomas...
  96. pmc Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family
    Xiuqin Zhang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:15694-700. 2006
    ..This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity...
  97. ncbi Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas
    Silvia Hernandez
    Universitat Pompeu Fabra, Institut Municipal d Investigacio Medica, Hospital del Mar, Barcelona, Spain
    J Clin Oncol 24:3664-71. 2006
    To determine the frequency and the prognostic value of fibroblast growth factor receptor 3 (FGFR3) mutations in patients with nonmuscle invasive bladder tumors according to tumor stage and grade.
  98. pmc A novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndrome
    Reha M Toydemir
    Department of Human Genetics, University of Utah, Salt Lake City, UT, USA
    Am J Hum Genet 79:935-41. 2006
    Activating mutations of FGFR3, a negative regulator of bone growth, are well known to cause a variety of short-limbed bone dysplasias and craniosynostosis syndromes...
  99. ncbi Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder tumors
    Silvia Hernandez
    Department de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    J Invest Dermatol 127:1664-6. 2007
    ..Based on the occurrence of fibroblast growth factor receptor 3 (FGFR3) mutations in seborrheic keratosis and urothelial carcinomas (UC), and the identification of ..
  100. pmc Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer
    D C Tomlinson
    Cancer Research UK Clinical Centre, St James s University Hospital, Beckett Street, Leeds, UK
    Oncogene 26:5889-99. 2007
    ..low-grade non-invasive papillary urothelial cell carcinomas contain activating point mutations of fibroblast growth factor receptor 3 (FGFR3)...
  101. ncbi Human immortalized chondrocytes carrying heterozygous FGFR3 mutations: an in vitro model to study chondrodysplasias
    Catherine Benoist-Lasselin
    INSERM U781, Hopital Necker Enfants Malades, 149 rue de Sevres, Paris, France
    FEBS Lett 581:2593-8. 2007
    Achondroplasia and thanatophoric dysplasia are human chondrodysplasias caused by mutations in the fibroblast growth factor receptor 3 (FGFR3) gene...

Research Grants78

  1. Fast calcium responses along arteriolar endothelium in vivo
    Pooneh Bagher; Fiscal Year: 2010
    ..Stimulating with acetylcholine (ACh) initiates signals that propagate from cell to cell along the endothelium to initiate SMC relaxation and thereby ..
  2. Steven S Segal; Fiscal Year: 2016
    ..Stimulating with acetylcholine (ACh) initiates complementary signals that propagate along the endothelium to relax consecutive SMC along vessel ..
  3. Mike T Lin; Fiscal Year: 2014
    ..In response to cholinergic stimulation (e.g. acetylcholine, ACh), a transient elevation of [Ca^*]j activates apamin-sensitive, voltage-independent Ca^*-activated K"^ channels, SKS ..
  4. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    ..A standard model to evaluate forearm endothelial function will be used. Acetylcholine (ACH) will be infused into the brachial artery to provoke synthesis and release of endothelial nitric oxide (NO), and ..
  5. PETER NIGEL UNWIN; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The nicotinic Acetylcholine (ACh) receptor mediates fast synaptic transmission by converting transiently to an open-channel form when activated by ACh released into the synaptic cleft...
  6. Nicotinic Acetylcholine Receptor Structure, Thermal Motion and Gating
    Michaela Jansen; Fiscal Year: 2011
    ..The recent publication of the ACh binding protein (AChBP) and Torpedo AChR structures has allowed new insights into the three dimensional structure ..
  7. KENNETH W GRASING; Fiscal Year: 2015
    ..In contrast, elevated levels of acetylcholine (ACh) in the nucleus accumbens may inhibit appetitive behaviors, including drug-seeking...
  8. James J Galligan; Fiscal Year: 2016
    ..Interneurons which project in an oral-anal direction release acetylcholine (ACh) and ATP as fast synaptic transmitters, while neurons that project in an anal-oral direction release ACh...
  9. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard K Gordon; Fiscal Year: 2010
    ..the oxime does not penetrate the blood brain barrier (BBS), removal of excessive accumulation of acetylcholine (ACh) is not accomplished by acetylcholinesterase (AChE)...
  10. Regulation of conducted hyperpolarization in microvascular endothelial cell tubes
    ERIK JOSEF BEHRINGER; Fiscal Year: 2012
    ..My working model of CVD is that EC hyperpolarization (e.g., in response to acetylcholine, ACh) reflects a local rise in calcium ([Ca2+]i) which activates small- and intermediate-conductance Ca2+-activated K+ ..
  11. John P Cooke; Fiscal Year: 2014
    ..nAChR is a ligand-gated cationic channel that is activated by the endogenous signaling molecule, acetylcholine (ACh)...
  12. STUDIES USING PURIFIED ACETYLCHOLINE RECEPTORS
    JON MARTIN LINDSTROM; Fiscal Year: 2012
    ..Most AChRs are heteromeric, with two ACh binding sites formed by subunit pairs (e.g. a4[unreadable]2) and a fifth "accessory" subunit (e.g...
  13. Paul D Gardner; Fiscal Year: 2014
    ..neuronal nicotinic acetylcholine receptors (nAChRs), cognate receptors of the endogenous ligand acetylcholine (ACh)...
  14. Alpha5 Subunits in Alpha4beta2 Nicotinic Receptors: Assembly and Function
    CRYSTAL N DILWORTH; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Nicotinic acetylcholine (ACh) receptors (nAChRs) are prolific receptors found in the peripheral and central nervous system...
  15. Ethanol Regulation of Neuronal Nicotinic Receptor Expression in Reward Circuitry
    Andrew R Tapper; Fiscal Year: 2010
    ..receptors are ligand-gated cation channels activated by the endogenous neurotransmitter, acetylcholine (ACh), as well as the highly addictive component of tobacco, nicotine...
  16. Robert Schwarcz; Fiscal Year: 2014
    ..is designed to define the role of KYNA in the modulation of basal and stimulated glutamate and acetylcholine (ACh) levels in the PFC and in the mediation of a prefrontally- mediated cognitive behavior (perceptual set-shifting)...
  17. Alcohol, the vagus nerve and multi-organ inflammation
    John M Littleton; Fiscal Year: 2012
    ..restrains inflammation, in all the organs to which the vagus is distributed, by the tonic release of acetylcholine (ACh) onto nicotinic receptors (nicAChRs) of the alpha7- subtype...
  18. DEVELOPMENT OF LIGANDS FOR NICOTINIC RECEPTORS
    Frank Ivy Carroll; Fiscal Year: 2012
    ..Rather, they will be evaluated initially for their ability to alter ACh effects in oocytes containing 42, 34, and 7 nAChRs...
  19. KATHERINE AMANDA RADEK; Fiscal Year: 2016
    ..Stress likely exacerbates the clinical manifestations of AD by increasing epidermal ACh and, consequently, nAChR activation to compromise normal AMP regulation and microbial susceptibility...
  20. MARLA FELLER; Fiscal Year: 2016
    ..Using two-photon calcium imaging and state-of-art optical sensors that measure[?] extrasynaptic release of ACh and glutamate, we will test the hypothesis that these waves propagate via volume transmission...
  21. Marina R Picciotto; Fiscal Year: 2015
    ..In the last funding period we showed that interfering with endogenous ACh signaling using both nicotinic antagonists and low efficacy partial agonists of high affinity nAChRs had ..
  22. The Role of 5HT3aR GABAergic interneuron in sensory-motor integration in cortex
    SooHyun Lee; Fiscal Year: 2013
    ..We recently showed that all 5HT3aR neurons are potently modulated by serotonin (5HT) and acetylcholine (ACh) acting on ionotropic 5HT3a and nicotinic receptors, respectively (Lee et al., in pres)...
  23. ACETYLCHOLINE RECEPTOR FUNCTION
    Joseph H Steinbach; Fiscal Year: 2013
    ..is composed of five subunits: two pairs of a4-[unreadable]2 subunits form the two acetylcholine-binding sites (ACh, the neurotransmitter which activates the receptor) while the 5th subunit does not contribute to an ACh-binding ..
  24. WILLIAM BRYSON CAMPBELL; Fiscal Year: 2014
    ..11,12,15-THETA mediates a portion of the endothelium-dependent relaxations to acetylcholine (ACh), in- creases in flow and AA and opposes the action of vasoconstrictors...
  25. Calcium wave propagation along microvascular endothelial tubes
    MATTHEW JOHN SOCHA; Fiscal Year: 2012
    ..When delivered to a discrete site on an arteriole or FA, acetylcholine (ACh;the "gold standard" endothelium-dependent vasodilator) initiates a Ca+2 wave that travels from EC to EC for ..
  26. Vascular Endothelial Dysfunction in Older Adults: Dietary Sodium Restriction
    Kristen Jablonski; Fiscal Year: 2010
    ..dilation (FMD) and the forearm blood flow (FBF) response to an intrabrachial infusion of acetylcholine (ACh)...
  27. Naoki Yoshimura; Fiscal Year: 2014
    ..This mechanism is important to investigate because there is increasing evidence that non-neural acetylcholine (ACh) released from the urothelium during stretch can activate muscarinic receptors, leading to modulation of afferent ..
  28. The influence of diabetes on M2 muscarinic receptor contractile function
    KIRK JIHYON PAK; Fiscal Year: 2012
    ..A major neurotransmitter influencing contractility is acetylcholine (ACh), which acts via M2 and M3 muscarinic receptors (mAChRs) in smooth muscle...
  29. Niacin therapy to improve endothelial function in Sickle Cell Disease
    NAOMI L LUBAN; Fiscal Year: 2011
    ..demonstrate endothelial dysfunction in patients with sickle cell disease, a dysfunction characterized by decreased ACh dependent vasorelaxation in forearm blood flow studies, and that is distinct from the nitric oxide resistance ..
  30. P Jeffrey Conn; Fiscal Year: 2016
    ..to develop highly selective M1 receptor agonists have failed because of the high conservation of the orthosteric ACh binding site across all mAChR subtypes...
  31. Elucidation of M5 Muscarinic Receptor Neurophysiology using Allosteric Modulators
    Daniel J Foster; Fiscal Year: 2013
    ..the M5 receptor has been relatively unsuccessful due to the high conservation of the orthosteric, acetylcholine (ACh) binding site across all five muscarinic receptor subtypes (M1-M5)...
  32. Ocular diurnal rhythms and eye growth
    Debora L Nickla; Fiscal Year: 2012
    ..I propose to study three signal molecules--nitric oxide (NO), dopamine, and acetylcholine (ACh)-in relation to choroidal thickening and ocular growth...
  33. Development and Regulation of Cholinergic Synapses
    Andres Villu Maricq; Fiscal Year: 2013
    ..Rapid cholinergic neurotransmission at muscles and in the brain is via synaptically released acetylcholine (ACh), which binds to and activates ion-channel forming pentameric receptors (AChRs)...
  34. M4 Positive Allosteric Modulators for the Treatment of Schizophrenia
    CARRIE KIMBERLY JONES; Fiscal Year: 2013
    ..These compounds do not activate M4 directly, but dramatically potentiate the response of the receptor to ACh. The first series of M4 PAMs, represented by VU10010, induces a 47-fold potentiation of the M4 ACh concentration ..
  35. Tacrine Effects on Cocaine Self-Administration and Pharmacokinetic Measures
    KENNETH W GRASING; Fiscal Year: 2012
    ..Elevated levels of acetylcholine (ACh) in the nucleus accumbens may also serve to inhibit appetitive behaviors...
  36. JOHN JOSHUA LAWRENCE; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Acetylcholine (ACh) release from the medial septum-diagonal band of Broca (MS-DBB) to the hippocampus profoundly alters cellular excitability, network synchronization, and behavioral state...
  37. The Impact of Genetic Variability on Human Susceptibility to Chlorpyrifos
    ALICE LANGFORD CRANE; Fiscal Year: 2013
    ..The most important result of this inhibition is the accumulation of the neurotransmitter acetylcholine (ACh) in neuronal and muscular synapses leading to an initial overstimulation, followed by eventual exhaustion of ACh ..
  38. Cholinesterase Inhibitors in Alzheimer's Disease
    Debomoy K Lahiri; Fiscal Year: 2012
    ..drugs for AD are cholinesterase inhibitors (ChEI), which increase the brain's supply of acetylcholine (ACh) by inhibiting cholinesterases (ChE) enzyme and thus preserve cholinergic circuits, which are believed to mediate ..
  39. Steven M Sine; Fiscal Year: 2016
    ..Focusing on the acetylcholine receptor (AChR) at the motor synapse, we address the central question of how ACh binding triggers opening of an ion channel intrinsic to the AChR...
  40. Rivastigmine and Huperzine A as Potential Treatments for Cocaine Addiction
    Richard De La Garza; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Acetylcholine (ACh) is involved in brain reward and learning functions, and perturbations to this neurotransmitter system may contribute to substance abuse disorders...
  41. Modeling cholinergic modulation of fMRI memory networks in aging & MCI
    Alireza Atri; Fiscal Year: 2010
    ..research proposal aims to combine functional MRI (fMRI), memory testing, medications that affect acetylcholine (ACh), and mathematical modeling to investigate the effects of aging, amnestic-mild cognitive impairment (MCI - a ..
  42. CHOLINERGIC MECHANISMS OF REM SLEEP GENERATION
    Helen A Baghdoyan; Fiscal Year: 2013
    Cholinergic neurotransmission has unique relevance for mental health. Acetylcholine (ACh) plays a key role in generating the rapid eye movement (REM) phase of sleep, and REM sleep abnormalities typify some forms of depression...
  43. Margaret E Rice; Fiscal Year: 2016
    ..but on cholinergic interneurons, and show a pivotal role for DA release regulation by nicotinic acetylcholine (ACh) receptors (nAChRs) located on DA axons...
  44. Maria Medalla; Fiscal Year: 2014
    ..While a number of neuromodulators influence cortical network dynamics, this project will focus on acetylcholine (ACh) due to its critical role in learning and memory...
  45. KRISTEN LEANNE ZULOAGA; Fiscal Year: 2015
    ..dysfunction following cerebral ischemia in mice, responses to the endothelium-dependent vasodilator acetylcholine (ACh) will be compared in male and female mice before and after transient middle cerebral artery occlusion (tMCAO, 1h) ..
  46. PARASYMPATHETIC DYSFUNCTION IN OBESITY: EFFECT OF CHOLESTEROL ON VAChT
    Yifan Li; Fiscal Year: 2013
    ..Acetylcholine (Ach) is a major neurotransmitter of PSNS...
  47. Beth A Habecker; Fiscal Year: 2015
    ..A recent heart failure study found that gp130 cytokines stimulate acetylcholine (ACh) synthesis in cardiac sympathetic neurons, and our data suggest that cytokines stimulate ACh synthesis in cardiac ..
  48. Cholinergic Mechanisms in Spatial Attention
    Anita A Disney; Fiscal Year: 2012
    ..Studies in rodents suggest that acetylcholine (ACh) mediates attention, and cholinergic dysfunction is implicated in many cognitive neuropathologies...
  49. Galanin-opiate interactions
    Marina R Picciotto; Fiscal Year: 2012
    ..system, either directly through effects on dopamine (DA) neurons or indirectly through effects on acetylcholine (ACh) release, and that decreasing galanin activity increases sensitivity to morphine...
  50. Regulation of Cholinergic Transmission and Theta Rhythms by Endocannabinoids
    DANIEL ALAN NAGODE; Fiscal Year: 2012
    ..Although the distribution and pharmacological profiles of nicotinic and muscarinic acetylcholine (ACh) receptors (nAChRs and mAChRs, respectively) in the hippocampus are well-known, less is understood about the ..
  51. EPITHELIAL ACETYLCHOLINE IN ORAL BIOLOGY AND PATHOLOGY
    Sergei A Grando; Fiscal Year: 2012
    ..to support our ongoing studies toward identification of molecular mechanisms mediating effects of acetylcholine (ACh), its pharmacologic congeners and tobacco products on oral keratinocytes (OKC)...
  52. LIMITING FACTORS IN NORMAL AND AMBLYOPIC SPATIAL VISION
    DENNIS MICHAEL LEVI; Fiscal Year: 2012
    ..effective (stronger) using the cholinesterase inhibitor donepezil to increase the synaptic levels of Acetylcholine (Ach) in the brain, and thereby increase plasticity in the amblyopic visual system...
  53. Role of the Presynaptic Choline Transporter in Dictating Reserve Pool Capacity
    Ericka C Holmstrand; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Acetylcholine (ACh) is a neurotransmitter widely used throughout the brain and body to subserve functions critical to human health, including cardiovascular and autonomic health...
  54. David J Anderson; Fiscal Year: 2015
    ..multiple neuromodulatory systems have been implicated in arousal, including biogenic amines (BAs), acetylcholine (ACh), hormones and neuropeptides such as orexin...
  55. Molecular Analysis of Presynaptic Choline Transporters
    Randy D Blakely; Fiscal Year: 2013
    Acetylcholine (ACh) is a major neurotransmitter in the central and peripheral nervous system...
  56. CHRISTOPHER MANUEL GOMEZ; Fiscal Year: 2014
    ..We test the hypothesis that muscle calpain, acts through a Cdk5 pathway to cause reduced ACh vesicle release and impaired synaptic strength, to increase nNOS enzymatic activity and synaptic NO production...
  57. Real Time Screening for GIRK1/4 Channel Blockers
    Kenneth B Walsh; Fiscal Year: 2010
    ..One novel target for AF drug therapy is the acetylcholine-activated K+ channel (IK,Ach)...
  58. Paschalis Kratsios; Fiscal Year: 2014
    ..This is a much-anticipated goal in the MN field as currently only the acetylcholine (ACh) pathway genes serve as bona fide markers of MN terminal differentiation...
  59. Characterization of Cholinergic Modulation of Dopamine Neurotransmission
    Leslie A Sombers; Fiscal Year: 2010
    ..studies have suggested that one endogenous neurochemical that serves to regulate these DA neurons is acetylcholine (ACh);however, direct evidence characterizing this modulation in intact animals is lacking, due largely to the absence ..
  60. MARTIN F SARTER; Fiscal Year: 2014
    ..The CHT imports choline for the synthesis of acetylcholine (ACh) into cholinergic neurons and thereby controls the capacity of cholinergic neurons to sustain increases in ..
  61. Paul A Fuchs; Fiscal Year: 2016
    ..The neurotransmitter acetylcholine (ACh) opens ionotropic (cation-permeant) receptors (AChRs) composed of 19 and 110 subunits...
  62. MICHAEL THOMAS SHIPLEY; Fiscal Year: 2015
    ..This project will investigate - for the first time - how acetylcholine (ACh) and serotonin (5HT) modulate sensory processing in glomerular circuits...
  63. EICOSANOIDS, VASCULAR TONE AND BLOOD PRESSURE
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    ..In the rabbit aorta and mouse mesenteric artery, endothelium-dependent relaxations to acetylcholine (ACh) are reduced, but not blocked, by inhibitors of NO and PG synthesis...
  64. A Nonisotopic HTS Assay to Elucidate Choline Transporter (CHT) Modulators
    ALICIA RUGGIERO; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): In the brain, the chemical acetylcholine (ACh) exerts powerful modulatory control over arousal, motor and cognitive circuits, and has been found to be deficient in Alzheimer's Disease (AD)...
  65. Nicotinic regulation of cortical ACh release and behavioral function
    MARTIN F SARTER; Fiscal Year: 2010
    ..on presynaptic terminals and stimulate the release of several neurotransmitters, including acetylcholine (ACh)...
  66. Structure in vesicular acetylcholine transporter
    Stanley Parsons; Fiscal Year: 2009
    Vesicular acetylcholine transporter (VAChT) stores acetylcholine (ACh) in synaptic vesicles for evoked elease from cholinergic nerve terminals. It is allosterically inhibited by a compound called vesamicol...
  67. STRUCTURES OF ACETYLCHOLINE RECEPTORS
    Arthur Karlin; Fiscal Year: 2003
    The nicotine acetylcholine (ACh) receptors convert the binding of ACh into the opening of a cation-specific channel...
  68. MOLECULAR MECHANISMS OF FGFR RELATED SKELETAL DISORDERS
    Xin Yuan Fu; Fiscal Year: 2002
    ..HCH) and thanatoporic dysplasia types I and II (TDI and TDII), are caused by distinct mutations of fibroblast growth factor receptor 3 (FGFR3) which retard skeletal growth and development...
  69. FGF3 RECEPTOR/BMP4: PATHWAYS REGULATING SKELETAL GROWTH
    MICHAEL NASKI; Fiscal Year: 2003
    b>Fibroblast growth factor receptor 3 (FGFR3) is a chief regulator of endochondral bone growth, as evidenced by the discovery that the most common genetic cause of dwarfism, achondroplasia, results from mutations in FGFR3...
  70. Abberant Activation of FGFR3 Signaling in Human Cancer
    Daniel Donoghue; Fiscal Year: 2007
    ..This revised proposal will examine the role of aberrant FGFR3 signaling in the recruitment and activation of effector proteins that mediate proliferative and antiapoptotic ..
  71. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 2002
    ..Norepinephrine (NE) released from sympathetic nerves and acetylcholine (ACh) from parasympathetic cholinergic nerves were first suggested to be the respective transmitters for ..
  72. MECHANISMS OF THE MUSCARINIC ACETYLCHOLINE SYNAPTIC
    JOSEPH FRESCHI; Fiscal Year: 1991
    Acetylcholine (ACh) is a neurotransmitter widely distributed throughout the central and peripheral nervous systems of vertebrates and invertebrates...
  73. CEREBROVASCULAR NITRIC OXIDERGIC INNERVATION
    Tony Lee; Fiscal Year: 2005
    Cerebral blood vessels from several species are innervated by vasodilator nerves. Acetylcholine (ACh) released from parasympathetic cholinergic nerves was first suggested to be the transmitter for vasodilation...
  74. ANTERIOR CHAMBER FLUID ACETYLCHOLINE CONCENTRATION
    Jonathan Wirtschafter; Fiscal Year: 1980
    The origin(s), fate, and physiologic actions of endogenous acetylcholine (ACh) in the aqueous humor are little understood but may be important, particularly since cholinergic drugs are used to reduce intraocular pressure in glaucoma...
  75. Transmitter Repletion: Key to Phrenic-Diaphragm Function
    Erik van Lunteren; Fiscal Year: 2005
    ..Neurotransmission requires sufficient prejunctional release of acetylcholine (ACh) to ensure muscle contraction...
  76. Murine Models of Presynaptic Neuromuscular Disease
    WILLIAM ATCHISON; Fiscal Year: 2009
    ..which present as skeletal muscle weakness are associated with presynaptic impairment of release of acetylcholine (ACh)...
  77. MODULATION OF NEUROTRANSMITTER RELEASE BY CANNABINOIDS
    Andrew Gifford; Fiscal Year: 2002
    ..from rat brain slices suggests that cannabinoid receptor activation produces a marked inhibition of the release of ACh in the hippocampus and also to lesser extent in the nucleus accumbens...
  78. SPATIO-TEMPORAL PERIODICITY IN ARTIAL FIBRILLATION
    JOSE JALIFE; Fiscal Year: 2006
    ..To compare the global mechanisms of acute AF, study in both species the effects of ACh on the activity of the high-frequency sources that maintain acute AF, and determine whether ACh increases ..