FLJ10261

Summary

Gene Symbol: FLJ10261
Description: anoctamin 1
Alias: DOG1, ORAOV2, TAOS2, TMEM16A, anoctamin-1, Ca2+-activated Cl- channel, anoctamin 1, calcium activated chloride channel, calcium activated chloride channel, discovered on gastrointestinal stromal tumors protein 1, oral cancer overexpressed 2, transmembrane protein 16A (eight membrane-spanning domains), tumor-amplified and overexpressed sequence 2
Species: human
Products:     FLJ10261

Top Publications

  1. Simon S, Grabellus F, Ferrera L, Galietta L, Schwindenhammer B, Mühlenberg T, et al. DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors. Cancer Res. 2013;73:3661-70 pubmed publisher
    ..The calcium-dependent chloride channel DOG1 (ANO1/TMEM16A), which is strongly and specifically expressed in GIST, is used as a diagnostic marker to differentiate GIST from ..
  2. Ubby I, Bussani E, Colonna A, Stacul G, Locatelli M, Scudieri P, et al. TMEM16A alternative splicing coordination in breast cancer. Mol Cancer. 2013;12:75 pubmed publisher
    b>TMEM16A, also known as Anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors...
  3. Tien J, Lee H, Minor D, Jan Y, Jan L. Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A. 2013;110:6352-7 pubmed publisher
    Transmembrane proteins with unknown function 16 (TMEM16A) is a calcium-activated chloride channel (CaCC) important for neuronal, exocrine, and smooth muscle functions...
  4. Wong N, Shelley Fraser G. Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour. Histopathology. 2010;57:250-8 pubmed publisher
    b>DOG1 and protein kinase C (PKC) theta are both sensitive immunohistochemical markers of gastrointestinal stromal tumour (GIST)...
  5. Katoh M, Katoh M. Identification and characterization of TMEM16E and TMEM16F genes in silico. Int J Oncol. 2004;24:1345-9 pubmed
    TMEM16A (FLJ10261 or ORAOV2) gene within the CCND1-FGF4-EMS1 amplicon at human chromosome 11q13.3 encodes transmembrane protein homologous to TMEM16B (C12orf3), TMEM16C (C11orf25), and TMEM16D (FLJ34272)...
  6. Tian Y, Schreiber R, Kunzelmann K. Anoctamins are a family of Ca2+-activated Cl- channels. J Cell Sci. 2012;125:4991-8 pubmed publisher
    b>Anoctamin 1 (Ano1; TMEM16A) and anoctamin 2 (Ano2; TMEM16B) are novel Cl(-) channels transiently activated by an increase in intracellular Ca(2+)...
  7. Gomez Pinilla P, Gibbons S, Bardsley M, Lorincz A, Pozo M, Pasricha P, et al. Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1370-81 pubmed publisher
    ..No other molecular marker currently exists to independently identify ICC. The expression of ANO1 (DOG1, TMEM16A), a Ca(2+)-activated Cl(-) channel, in gastrointestinal stromal tumors suggests it may be useful as an ICC marker...
  8. Tian Y, Schreiber R, Wanitchakool P, Kongsuphol P, Sousa M, Uliyakina I, et al. Control of TMEM16A by INO-4995 and other inositolphosphates. Br J Pharmacol. 2013;168:253-65 pubmed publisher
    ..Cl(-) secretion (CaCC) in airways and other tissues is due to activation of the Cl(-) channel TMEM16A (anoctamin 1)...
  9. Hartzell H, Yu K, Xiao Q, Chien L, Qu Z. Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels. J Physiol. 2009;587:2127-39 pubmed publisher
    ..Some members of this family are up-regulated in a number of tumours and functional deficiency in others is linked to developmental defects. ..
  10. Ríos Moreno M, Jaramillo S, Pereira Gallardo S, Vallejo A, Mora M, Garcia Escudero A, et al. Gastrointestinal stromal tumors (GISTs): CD117, DOG-1 and PKCθ expression. Is there any advantage in using several markers?. Pathol Res Pract. 2012;208:74-81 pubmed publisher
    ..Expression of CD117, DOG1 and PKCθ was investigated immunohistochemically in a series of 99 paraffin-embedded GISTs in order to determine ..

Detail Information

Publications62

  1. Simon S, Grabellus F, Ferrera L, Galietta L, Schwindenhammer B, Mühlenberg T, et al. DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors. Cancer Res. 2013;73:3661-70 pubmed publisher
    ..The calcium-dependent chloride channel DOG1 (ANO1/TMEM16A), which is strongly and specifically expressed in GIST, is used as a diagnostic marker to differentiate GIST from ..
  2. Ubby I, Bussani E, Colonna A, Stacul G, Locatelli M, Scudieri P, et al. TMEM16A alternative splicing coordination in breast cancer. Mol Cancer. 2013;12:75 pubmed publisher
    b>TMEM16A, also known as Anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors...
  3. Tien J, Lee H, Minor D, Jan Y, Jan L. Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A. 2013;110:6352-7 pubmed publisher
    Transmembrane proteins with unknown function 16 (TMEM16A) is a calcium-activated chloride channel (CaCC) important for neuronal, exocrine, and smooth muscle functions...
  4. Wong N, Shelley Fraser G. Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour. Histopathology. 2010;57:250-8 pubmed publisher
    b>DOG1 and protein kinase C (PKC) theta are both sensitive immunohistochemical markers of gastrointestinal stromal tumour (GIST)...
  5. Katoh M, Katoh M. Identification and characterization of TMEM16E and TMEM16F genes in silico. Int J Oncol. 2004;24:1345-9 pubmed
    TMEM16A (FLJ10261 or ORAOV2) gene within the CCND1-FGF4-EMS1 amplicon at human chromosome 11q13.3 encodes transmembrane protein homologous to TMEM16B (C12orf3), TMEM16C (C11orf25), and TMEM16D (FLJ34272)...
  6. Tian Y, Schreiber R, Kunzelmann K. Anoctamins are a family of Ca2+-activated Cl- channels. J Cell Sci. 2012;125:4991-8 pubmed publisher
    b>Anoctamin 1 (Ano1; TMEM16A) and anoctamin 2 (Ano2; TMEM16B) are novel Cl(-) channels transiently activated by an increase in intracellular Ca(2+)...
  7. Gomez Pinilla P, Gibbons S, Bardsley M, Lorincz A, Pozo M, Pasricha P, et al. Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1370-81 pubmed publisher
    ..No other molecular marker currently exists to independently identify ICC. The expression of ANO1 (DOG1, TMEM16A), a Ca(2+)-activated Cl(-) channel, in gastrointestinal stromal tumors suggests it may be useful as an ICC marker...
  8. Tian Y, Schreiber R, Wanitchakool P, Kongsuphol P, Sousa M, Uliyakina I, et al. Control of TMEM16A by INO-4995 and other inositolphosphates. Br J Pharmacol. 2013;168:253-65 pubmed publisher
    ..Cl(-) secretion (CaCC) in airways and other tissues is due to activation of the Cl(-) channel TMEM16A (anoctamin 1)...
  9. Hartzell H, Yu K, Xiao Q, Chien L, Qu Z. Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels. J Physiol. 2009;587:2127-39 pubmed publisher
    ..Some members of this family are up-regulated in a number of tumours and functional deficiency in others is linked to developmental defects. ..
  10. Ríos Moreno M, Jaramillo S, Pereira Gallardo S, Vallejo A, Mora M, Garcia Escudero A, et al. Gastrointestinal stromal tumors (GISTs): CD117, DOG-1 and PKCθ expression. Is there any advantage in using several markers?. Pathol Res Pract. 2012;208:74-81 pubmed publisher
    ..Expression of CD117, DOG1 and PKCθ was investigated immunohistochemically in a series of 99 paraffin-embedded GISTs in order to determine ..
  11. Dutta A, Khimji A, Kresge C, Bugde A, Dougherty M, Esser V, et al. Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium. J Biol Chem. 2011;286:766-76 pubmed publisher
    ..The present studies in human, mouse, and rat BECs provide evidence that TMEM16A is the operative channel and contributes to Ca(2+)-activated Cl(-) secretion in response to extracellular ..
  12. Miettinen M, Wang Z, Lasota J. DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. Am J Surg Pathol. 2009;33:1401-8 pubmed publisher
    ..GISTs of different sites and histologic subtypes, and 672 other tumors and normal tissues for discovered on GIST-1 (DOG1) clone K9, a newly introduced immunohistochemical marker, a chloride channel protein...
  13. Hwang S, Blair P, Britton F, O Driscoll K, Hennig G, Bayguinov Y, et al. Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J Physiol. 2009;587:4887-904 pubmed publisher
    ..We investigated the expression and function of a new class of CaCC, anoctamin 1 (ANO1), encoded by Tmem16a, which was discovered to be highly expressed in ICC in a microarray screen...
  14. Novelli M, Rossi S, Rodriguez Justo M, Taniere P, Seddon B, Toffolatti L, et al. DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. Histopathology. 2010;57:259-70 pubmed publisher
    ..Immunohistochemistry with a panel of antibodies [CD117, DOG1, protein kinase C (PKC)-theta, nestin, CD34, smooth muscle actin (SMA), desmin, S100 and CD171] was performed on ..
  15. Ousingsawat J, Kongsuphol P, Schreiber R, Kunzelmann K. CFTR and TMEM16A are separate but functionally related Cl- channels. Cell Physiol Biochem. 2011;28:715-24 pubmed publisher
    ..Recent findings showing that TMEM16A forms the essential part of CaCC, prompted us to examine whether CFTR controls TMEM16A...
  16. Scudieri P, Sondo E, Ferrera L, Galietta L. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. Exp Physiol. 2012;97:177-83 pubmed publisher
    ..Recently, the question of the molecular identity of CaCCs has apparently been resolved with the identification of TMEM16A protein (also known as anoctamin-1)...
  17. Perez Cornejo P, Gokhale A, Duran C, Cui Y, Xiao Q, Hartzell H, et al. Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network. Proc Natl Acad Sci U S A. 2012;109:10376-81 pubmed publisher
    The newly discovered Ca(2+)-activated Cl(-) channel (CaCC), Anoctamin 1 (Ano1 or TMEM16A), has been implicated in vital physiological functions including epithelial fluid secretion, gut motility, and smooth muscle tone...
  18. Katoh M, Katoh M. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. Int J Oncol. 2003;22:1375-81 pubmed
    ..1) derived from the uncharacterized FLJ10261 gene. Here, we characterized the FLJ10261 gene by using bioinformatics. NM_018043...
  19. Stanich J, Gibbons S, Eisenman S, Bardsley M, Rock J, Harfe B, et al. Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol. 2011;301:G1044-51 pubmed publisher
    ..These data led us to conclude that Ano1 regulates proliferation at the G(1)/S transition of the cell cycle and may play a role in tumorigenesis...
  20. Scudieri P, Sondo E, Caci E, Ravazzolo R, Galietta L. TMEM16A-TMEM16B chimaeras to investigate the structure-function relationship of calcium-activated chloride channels. Biochem J. 2013;452:443-55 pubmed publisher
    b>TMEM16A and TMEM16B proteins are CaCCs (Ca2+-activated Cl- channels) with eight putative transmembrane segments...
  21. Moreno Smith M, Halder J, Meltzer P, Gonda T, Mangala L, Rupaimoole R, et al. ATP11B mediates platinum resistance in ovarian cancer. J Clin Invest. 2013;123:2119-30 pubmed publisher
    ..In conclusion, inhibition of ATP11B expression could serve as a therapeutic strategy to overcome cisplatin resistance...
  22. Filipuzzi I, Steffen J, Germain M, Goepfert L, Conti M, Potting C, et al. Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import. Nat Chem Biol. 2017;13:1239-1244 pubmed publisher
    ....
  23. Jefferson R, Min D, Corin K, Wang J, Bowie J. Applications of Single-Molecule Methods to Membrane Protein Folding Studies. J Mol Biol. 2017;: pubmed publisher
    ..Single-molecule methods may greatly alter this picture, however, because the ability to work at or near infinite dilution removes aggregation problems, one of the main technical challenges of membrane protein folding studies...
  24. Zhu M, Sung T, Kurahashi M, O Kane L, O Driscoll K, Koh S, et al. Na+-K+-Cl- cotransporter (NKCC) maintains the chloride gradient to sustain pacemaker activity in interstitial cells of Cajal. Am J Physiol Gastrointest Liver Physiol. 2016;311:G1037-G1046 pubmed publisher
    ..Recovery of Cl- via NKCC1 might have additional consequences on shaping the waveforms of slow waves via Na+ entry into microdomains...
  25. Wang H, Zhou Y, Guo Z, Dong Y, Xu J, Huang H, et al. Sitagliptin Attenuates Endothelial Dysfunction of Zucker Diabetic Fatty Rats: Implication of the Antiperoxynitrite and Autophagy. J Cardiovasc Pharmacol Ther. 2018;23:66-78 pubmed publisher
    ..The protective effects of sitagliptin are possibly related to antiperoxynitrite and promoting autophagy...
  26. Wang S, Li Z, Yu Y, Xu J. Folding Membrane Proteins by Deep Transfer Learning. Cell Syst. 2017;5:202-211.e3 pubmed publisher
    ..We estimated that our method could predict correct folds for 1,345-1,871 reviewed human multi-pass MPs including a few hundred new folds, which shall facilitate the discovery of drugs targeting at MPs. ..
  27. Teymournejad O, Mobarez A, Hassan Z, Talebi Bezmin Abadi A. Binding of the Helicobacter pylori OipA causes apoptosis of host cells via modulation of Bax/Bcl-2 levels. Sci Rep. 2017;7:8036 pubmed publisher
    ..These findings suggest that OipA can bind and induce toxic events as well as triggering apoptotic cascade in host gastric cells through intrinsic pathway. ..
  28. Shin S, Lee D, Gil H, Kim B, Choe J, Kim J, et al. Agerarin, identified from Ageratum houstonianum, stimulates circadian CLOCK-mediated aquaporin-3 gene expression in HaCaT keratinocytes. Sci Rep. 2017;7:11175 pubmed publisher
    ..In conclusion, agerarin is a bioactive compound in AHE responsible for CLOCK-mediated AQP3 expression in keratinocytes. ..
  29. Barber J. Photosynthetic water splitting by the Mn4Ca2+OX catalyst of photosystem II: its structure, robustness and mechanism. Q Rev Biophys. 2017;50:e13 pubmed publisher
    ..Finally the relevance of our understanding of PSII is discussed in terms of artificial photosynthesis with emphasis on inorganic water splitting catalysts as oxygen generating photoelectrodes...
  30. Toyoda Y, Takada T, Miyata H, Ishikawa T, Suzuki H. Regulation of the Axillary Osmidrosis-Associated ABCC11 Protein Stability by N-Linked Glycosylation: Effect of Glucose Condition. PLoS ONE. 2016;11:e0157172 pubmed publisher
    ....
  31. Lai S, Gu Z, Zhao M, Li X, Ma Y, Luo L, et al. Toxic effect of acrylamide on the development of hippocampal neurons of weaning rats. Neural Regen Res. 2017;12:1648-1654 pubmed publisher
    ..These data suggest that acrylamide exerts dose-dependent toxic effects on the growth and development of hippocampal neurons of weaning rats...
  32. Kasza I, Várady G, Andrikovics H, Koszarska M, Tordai A, Scheffer G, et al. Expression levels of the ABCG2 multidrug transporter in human erythrocytes correspond to pharmacologically relevant genetic variations. PLoS ONE. 2012;7:e48423 pubmed publisher
    ..Extension of this methodology to other disease-related or pharmacologically important membrane proteins may yield new protein biomarkers for personalized diagnostics...
  33. Awasthi S, Hallene K, Fazio V, Singhal S, Cucullo L, Awasthi Y, et al. RLIP76, a non-ABC transporter, and drug resistance in epilepsy. BMC Neurosci. 2005;6:61 pubmed
    ..Because of a significant overlap in substrates between P-glycoprotein and RLIP76, present studies were carried out to determine the potential role of RLIP76 in AED transport in the brain...
  34. Ghaedi K, Tamura S, Okumoto K, Matsuzono Y, Fujiki Y. The peroxin pex3p initiates membrane assembly in peroxisome biogenesis. Mol Biol Cell. 2000;11:2085-102 pubmed
    ..Thus, Pex3p assembles membrane vesicles before the matrix proteins are translocated...
  35. Ehrmann M, Beckwith J. Proper insertion of a complex membrane protein in the absence of its amino-terminal export signal. J Biol Chem. 1991;266:16530-3 pubmed
    ....
  36. Chaves L, Tomich L, Salomão M, Leite G, Ramos J, Martins R, et al. High mortality of bloodstream infection outbreak caused by carbapenem-resistant P. aeruginosa producing SPM-1 in a bone marrow transplant unit. J Med Microbiol. 2017;: pubmed publisher
    ..0089) were associated with CRPa-BSI. However, when MASCC>21 points and platelets were added in the final multivariate analysis, only prior use of carbapenems remained as an independent risk factor for CRPa-BSI (P=0.043)...
  37. Rajvanshi P, Arya M, Rajasekharan R. The stress-regulatory transcription factors Msn2 and Msn4 regulate fatty acid oxidation in budding yeast. J Biol Chem. 2017;292:18628-18643 pubmed publisher
    ....
  38. Arbo B, Hoppe J, Rodrigues K, Garcia Segura L, Salbego C, Ribeiro M. 4'-Chlorodiazepam is neuroprotective against amyloid-beta in organotypic hippocampal cultures. J Steroid Biochem Mol Biol. 2017;171:281-287 pubmed publisher
    ..In summary, our results show that 4'-CD is neuroprotective against Aβ by a mechanism involving the modulation of SOD protein expression...
  39. Mukherjee I, Barlowe C. Overexpression of Sly41 suppresses COPII vesicle-tethering deficiencies by elevating intracellular calcium levels. Mol Biol Cell. 2016;27:1635-49 pubmed publisher
    ..These results show that calcium positively regulates the SNARE-dependent fusion stage of ER-Golgi transport...
  40. Holzinger A, Roscher A, Landgraf P, Lichtner P, Kammerer S. Genomic organization and chromosomal localization of the human peroxisomal membrane protein-1-like protein (PXMP1-L) gene encoding a peroxisomal ABC transporter. FEBS Lett. 1998;426:238-42 pubmed
    ..The data presented will enable sequence analysis of the PXMP1-L gene in X-ALD patients and facilitate the analysis of PXMP1-L function...
  41. Barua P, Subba P, Lande N, Mangalaparthi K, Prasad T, Chakraborty S, et al. Gel-based and gel-free search for plasma membrane proteins in chickpea (Cicer arietinum L.) augments the comprehensive data sets of membrane protein repertoire. J Proteomics. 2016;143:199-208 pubmed publisher
    ..Finally an inventory of the complete set of PM proteins, identified in several monocot and dicot species, was created for comparative study with the generated PM protein dataset of chickpea...
  42. Tanabe Y, Naito Y, Vasuta C, Lee A, Soumounou Y, Linhoff M, et al. IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α. Nat Commun. 2017;8:408 pubmed publisher
    ..Here the authors show that IgSF21 interacts with neurexin2α to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission. ..
  43. Gilardi A, Bhamidimarri S, Brönstrup M, Bilitewski U, Marreddy R, Pos K, et al. Biophysical characterization of E. coli TolC interaction with the known blocker hexaamminecobalt. Biochim Biophys Acta. 2017;1861:2702-2709 pubmed publisher
    ..Biophysical characterization of the binding processes will support future identification and optimisation of more potent TolC blockers in order to validate TolC as a pharmaceutical target. ..
  44. Price A, Messinger J, Luftig M. c-Myc Represses Transcription of the Epstein-Barr Virus Latent Membrane Protein 1 Early After Primary B Cell Infection. J Virol. 2017;: pubmed publisher
    ..Ultimately, understanding the regulation of EBV-encoded oncogenes will allow us to better treat cancers that rely on these viral products for survival...
  45. Jeppesen T, Kristensen L, Nielsen C, Petersen L, Kristensen J, Behrens C, et al. Site-specific 64Cu labelling of the serine protease, active site inhibited factor seven azide (FVIIai-N3), using copper free click chemistry. Bioconjug Chem. 2017;: pubmed publisher
    ..In conclusion, FVIIai was radiolabelled with 64Cu in single well defined position of the protein. This method can be utilized to prepare conjugates from serine proteases with the label at a specific position...