GJC1

Summary

Gene Symbol: GJC1
Description: gap junction protein gamma 1
Alias: CX45, GJA7, gap junction gamma-1 protein, CTC-296K1.4, connexin-45, gap junction alpha-7 protein, gap junction protein, gamma 1, 45kDa
Species: human
Products:     GJC1

Top Publications

  1. Trease A, Capuccino J, Contreras J, Harris A, Sorgen P. Intramolecular signaling in a cardiac connexin: Role of cytoplasmic domain dimerization. J Mol Cell Cardiol. 2017;111:69-80 pubmed publisher
    ..heart, the spatio-temporal regulation and distinct functional properties of the three dominant connexins (Cx43, Cx45, and Cx40) suggests non-redundant physiological roles for each isoform...
  2. Park D, Fishman G. The cardiac conduction system. Circulation. 2011;123:904-15 pubmed publisher
  3. Ismail F, Moinfar Z, Prochnow N, Dambach H, Hinkerohe D, Haase C, et al. Dexamethasone and levetiracetam reduce hetero-cellular gap-junctional coupling between F98 glioma cells and glial cells in vitro. J Neurooncol. 2017;131:469-476 pubmed publisher
    ..The expression of four types of connexins (Cxs), including Cx32, Cx36, Cx43 and Cx45, and microglial phenotypes were analyzed by immunocytochemistry...
  4. Dyszkiewicz Konwińska M, Bryja A, Jopek K, Budna J, Bukowska D, Antosik P, et al. Expression of connexins in porcine buccal pouch mucosa cells during real-time long-term cell proliferation in vitro: a primary culture approach. J Biol Regul Homeost Agents. 2017;31:567-577 pubmed
    In this study we investigated the expression of connexins Cx36, Cx37, Cx40, Cx43, and Cx45 mRNAs during real-time cellular proliferation in vitro. The oral mucosa cells were isolated from 80 pubertal crossbred Landrace gilts...
  5. Tsai M, Lan K, Huang K, Huang F, Kung F, Chang S. Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles. Fertil Steril. 2003;80:1437-43 pubmed
    ..The luteinized granulosa cells from the large follicles are relatively quiescent in the connexin mRNA expression. In addition to the volume, the mRNA levels of cx43 may serve as a marker to predict the outcome of oocytes. ..
  6. Liu L, Pertsemlidis A, Ding L, Story M, Steinberg M, Sebastiani P, et al. Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease. Exp Biol Med (Maywood). 2016;241:706-18 pubmed publisher
    ..In addition, we identified SNPs in the SPARC, GJC1, EFTUD2 and JAZF1 genes as novel candidates associated with HbF levels...
  7. Petersen F, Rodrigo R, Richter M, Kostin S. The effects of polyunsaturated fatty acids and antioxidant vitamins on atrial oxidative stress, nitrotyrosine residues, and connexins following extracorporeal circulation in patients undergoing cardiac surgery. Mol Cell Biochem. 2017;433:27-40 pubmed publisher
    ..stress are involved in the development of an arrhythmogenic substrate by their effect on connexins (Cx40, Cx43 and Cx45) abundance and distribution pattern...
  8. Kanter H, Saffitz J, Beyer E. Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45. J Mol Cell Cardiol. 1994;26:861-8 pubmed
    ..and genomic cloning to isolate DNA encoding the gap junction proteins human connexin40 (Cx40) and connexin45 (Cx45)...
  9. Kotsias B, Salim M, Peracchia L, Peracchia C. Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes. J Membr Biol. 2006;214:1-8 pubmed
    ..functional interaction between CFTR and gap junction channels, we coexpressed in Xenopus oocytes CFTR and either Cx45, Cx40, Cx32 or Cx50 and monitored junctional conductance (G (j)) and its sensitivity to transjunctional voltage (V (..
  10. Wörsdörfer P, Bosen F, Gebhardt M, Russ N, Zimmermann K, Komla Kessie D, et al. Abrogation of Gap Junctional Communication in ES Cells Results in a Disruption of Primitive Endoderm Formation in Embryoid Bodies. Stem Cells. 2017;35:859-871 pubmed publisher
    ..Connexin (Cx) 43 and Cx45 are co-expressed in embryonic stem (ES) cells, form gap junctions and are considered to exhibit adhesive function ..

Detail Information

Publications41

  1. Trease A, Capuccino J, Contreras J, Harris A, Sorgen P. Intramolecular signaling in a cardiac connexin: Role of cytoplasmic domain dimerization. J Mol Cell Cardiol. 2017;111:69-80 pubmed publisher
    ..heart, the spatio-temporal regulation and distinct functional properties of the three dominant connexins (Cx43, Cx45, and Cx40) suggests non-redundant physiological roles for each isoform...
  2. Park D, Fishman G. The cardiac conduction system. Circulation. 2011;123:904-15 pubmed publisher
  3. Ismail F, Moinfar Z, Prochnow N, Dambach H, Hinkerohe D, Haase C, et al. Dexamethasone and levetiracetam reduce hetero-cellular gap-junctional coupling between F98 glioma cells and glial cells in vitro. J Neurooncol. 2017;131:469-476 pubmed publisher
    ..The expression of four types of connexins (Cxs), including Cx32, Cx36, Cx43 and Cx45, and microglial phenotypes were analyzed by immunocytochemistry...
  4. Dyszkiewicz Konwińska M, Bryja A, Jopek K, Budna J, Bukowska D, Antosik P, et al. Expression of connexins in porcine buccal pouch mucosa cells during real-time long-term cell proliferation in vitro: a primary culture approach. J Biol Regul Homeost Agents. 2017;31:567-577 pubmed
    In this study we investigated the expression of connexins Cx36, Cx37, Cx40, Cx43, and Cx45 mRNAs during real-time cellular proliferation in vitro. The oral mucosa cells were isolated from 80 pubertal crossbred Landrace gilts...
  5. Tsai M, Lan K, Huang K, Huang F, Kung F, Chang S. Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles. Fertil Steril. 2003;80:1437-43 pubmed
    ..The luteinized granulosa cells from the large follicles are relatively quiescent in the connexin mRNA expression. In addition to the volume, the mRNA levels of cx43 may serve as a marker to predict the outcome of oocytes. ..
  6. Liu L, Pertsemlidis A, Ding L, Story M, Steinberg M, Sebastiani P, et al. Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease. Exp Biol Med (Maywood). 2016;241:706-18 pubmed publisher
    ..In addition, we identified SNPs in the SPARC, GJC1, EFTUD2 and JAZF1 genes as novel candidates associated with HbF levels...
  7. Petersen F, Rodrigo R, Richter M, Kostin S. The effects of polyunsaturated fatty acids and antioxidant vitamins on atrial oxidative stress, nitrotyrosine residues, and connexins following extracorporeal circulation in patients undergoing cardiac surgery. Mol Cell Biochem. 2017;433:27-40 pubmed publisher
    ..stress are involved in the development of an arrhythmogenic substrate by their effect on connexins (Cx40, Cx43 and Cx45) abundance and distribution pattern...
  8. Kanter H, Saffitz J, Beyer E. Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45. J Mol Cell Cardiol. 1994;26:861-8 pubmed
    ..and genomic cloning to isolate DNA encoding the gap junction proteins human connexin40 (Cx40) and connexin45 (Cx45)...
  9. Kotsias B, Salim M, Peracchia L, Peracchia C. Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes. J Membr Biol. 2006;214:1-8 pubmed
    ..functional interaction between CFTR and gap junction channels, we coexpressed in Xenopus oocytes CFTR and either Cx45, Cx40, Cx32 or Cx50 and monitored junctional conductance (G (j)) and its sensitivity to transjunctional voltage (V (..
  10. Wörsdörfer P, Bosen F, Gebhardt M, Russ N, Zimmermann K, Komla Kessie D, et al. Abrogation of Gap Junctional Communication in ES Cells Results in a Disruption of Primitive Endoderm Formation in Embryoid Bodies. Stem Cells. 2017;35:859-871 pubmed publisher
    ..Connexin (Cx) 43 and Cx45 are co-expressed in embryonic stem (ES) cells, form gap junctions and are considered to exhibit adhesive function ..
  11. Foss B, Tronstad K, Bruserud Ø. Connexin-based signaling in acute myelogenous leukemia (AML). Biochim Biophys Acta. 2010;1798:1-8 pubmed publisher
    ....
  12. Sohl G, Joussen A, Kociok N, Willecke K. Expression of connexin genes in the human retina. BMC Ophthalmol. 2010;10:27 pubmed publisher
    ..In the mouse retina, Cx43 could be localized mostly between astroglial cells whereas expression of Cx36, Cx45 and Cx57 genes has been detected in different neuronal subtypes...
  13. Li X, Simard J. Connexin45 gap junction channels in rat cerebral vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2001;281:H1890-8 pubmed
    ..Here, we report data consistent with identification of Cx45. Immunofluorescence using anti-human Cx45 and anti-mouse Cx45 antibodies revealed labeling between alpha-actin-..
  14. Kausalya P, Reichert M, Hunziker W. Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells. FEBS Lett. 2001;505:92-6 pubmed
    ..b>Cx45 interacts with the PDZ domains of ZO-1 and ZO-3, but not ZO-2, via a short C-terminal PDZ binding motif (SVWI)...
  15. Donahue H, Li Z, Zhou Z, Yellowley C. Differentiation of human fetal osteoblastic cells and gap junctional intercellular communication. Am J Physiol Cell Physiol. 2000;278:C315-22 pubmed
    ..We found that hFOB 1.19 cells express abundant connexin 43 (Cx43) protein and mRNA. In contrast, Cx45 mRNA was expressed to a lesser degree, and Cx26 and Cx32 mRNA were not detected. Culturing hFOB 1. 19 cells at 39...
  16. Heinrich M, Oberbach A, Schlichting N, Stolzenburg J, Neuhaus J. Cytokine effects on gap junction communication and connexin expression in human bladder smooth muscle cells and suburothelial myofibroblasts. PLoS ONE. 2011;6:e20792 pubmed publisher
    ..Connexin (Cx) 43 and Cx45 are the most important gap junction proteins in bladder smooth muscle cells (hBSMC) and suburothelial ..
  17. Vozzi C, Dupont E, Coppen S, Yeh H, Severs N. Chamber-related differences in connexin expression in the human heart. J Mol Cell Cardiol. 1999;31:991-1003 pubmed
    ..Three additional connexin isoforms, Cx40, Cx45 and Cx37, of distinctive functional capacities in vitro, are expressed in cardiovascular cells, but our knowledge ..
  18. Li J, Ke H, He Y, Wen L, Xu W, Wu Z, et al. Transplantation of mesenchymal stem cells modulated Cx43 and Cx45 expression in rats with myocardial infarction. Cytotechnology. 2017;: pubmed publisher
    ..is known about the influence of mesenchymal stem cell (MSC) transplantation on connexin43 (Cx43) and connexin45 (Cx45) remodeling in the ischemic heart...
  19. Shin M, Lee S, Son Y, Park Y, Jeong S, Kim E, et al. Lysophosphatidic Acid Accelerates Development of Porcine Embryos by Activating Formation of the Blastocoel. Mol Reprod Dev. 2017;: pubmed publisher
    ..Expression of Connexin 43 and gap junction and cell adhesion-related genes (GJC1 and CDH1, respectively) was also higher in LPA-treated compared to control embryos...
  20. Chu M, Novak S, Cover C, Wang A, Chinyere I, Juneman E, et al. Increased Cardiac Arrhythmogenesis Associated with Gap Junction Remodeling with Upregulation of RNA Binding Protein FXR1. Circulation. 2017;: pubmed publisher
    ..FXR1 associates with intercalated discs and integral gap junction proteins Cx43, Cx45 and ZO-1 were identified as novel mRNA targets of FXR1 using a BioID proximity assay and RNA immunoprecipitation...
  21. Kopanic J, Schlingmann B, Koval M, Lau A, Sorgen P, Su V. Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75). Biochem J. 2015;466:571-85 pubmed publisher
    ..We have discovered two additional connexins, connexin40 (Cx40) and connexin45 (Cx45), that interact with CIP75...
  22. Desplantez T, Halliday D, Dupont E, Severs N, Weingart R. Influence of v5/6-His tag on the properties of gap junction channels composed of connexin43, connexin40 or connexin45. J Membr Biol. 2011;240:139-50 pubmed publisher
    ..or connexin45 and connexins fused with a V5/6-His tag to the carboxyl terminus (CT) domain (Cx43-tag, Cx40-tag, Cx45-tag) were used to study connexin expression and the electrical properties of gap junction channels...
  23. Kurtz L, Madsen K, Kurt B, Jensen B, Walter S, Banas B, et al. High-level connexin expression in the human juxtaglomerular apparatus. Nephron Physiol. 2010;116:p1-8 pubmed publisher
    ..These gap junctions are formed by cell-specific expression patterns of the vascular connexins Cx37, Cx40, Cx43 and Cx45. In order to obtain a first indication if gap junctions might play a similar important functional role in the ..
  24. Rackauskas M, Kreuzberg M, Pranevicius M, Willecke K, Verselis V, Bukauskas F. Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45. Biophys J. 2007;92:1952-65 pubmed
    ..properties of heterotypic gap junction (GJ) channels assembled between cells expressing wild-type Cx40, Cx43, or Cx45 and their fusion forms tagged with color variants of green fluorescent protein...
  25. Valiunas V, Doronin S, Valiuniene L, Potapova I, Zuckerman J, Walcott B, et al. Human mesenchymal stem cells make cardiac connexins and form functional gap junctions. J Physiol. 2004;555:617-26 pubmed
    ..The staining patterns for Cx45 rather were typified by granular cytoplasmic staining...
  26. Kaba R, Coppen S, Dupont E, Skepper J, Elneil S, Haw M, et al. Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts. Cell Commun Adhes. 2001;8:339-43 pubmed
    ..In general, these dynamic changes of connexins 43, 40 and 45 during mouse cardiac development appear to be mirrored in the human. ..
  27. Laing J, Manley Markowski R, Koval M, Civitelli R, Steinberg T. Connexin45 interacts with zonula occludens-1 in osteoblastic cells. Cell Commun Adhes. 2001;8:209-12 pubmed
    Connexin43 (Cx43) and Cx45 are co-expressed in a number of different tissues...
  28. Sun Y, Yang Y, Gong X, Wang X, Li R, Tan H, et al. Novel germline GJA5/connexin40 mutations associated with lone atrial fibrillation impair gap junctional intercellular communication. Hum Mutat. 2013;34:603-9 pubmed publisher
    ..This study is the first to demonstrate that the germline familial mutations in Cx40 impair the gap junctions through different mechanisms, which may predispose the mutant carriers to AF. ..
  29. Sirnes S, Honne H, Ahmed D, Danielsen S, Rognum T, Meling G, et al. DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer. Epigenetics. 2011;6:602-9 pubmed
    ..Expression of six (GJA1, GJA9, GJB1, GJB2, GJC1 and GJD3) connexin genes was detected in normal colonic tissue samples...
  30. del Castillo F, Cohen Salmon M, Charollais A, Caille D, Lampe P, Chavrier P, et al. Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins. Hum Mol Genet. 2010;19:262-75 pubmed publisher
    ..Sequence accession numbers. GenBank: Human CNST cDNA, NM_152609; mouse Cnst cDNA, NM_146105. ..
  31. Kléber A, Rudy Y. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev. 2004;84:431-88 pubmed
    ..This review attempts to synthesize results from computer simulations and experimental preparations to define mechanisms and biophysical principles that govern normal and abnormal conduction in the heart. ..
  32. Ye W, Yue B, Aoyama H, Kim N, Cameron J, Chen H, et al. Junctional delay, frequency, and direction-dependent uncoupling of human heterotypic Cx45/Cx43 gap junction channels. J Mol Cell Cardiol. 2017;111:17-26 pubmed publisher
    ..Connexin40 (Cx40) and Cx43 are the dominant connexins in atrial myocytes, while Cx45 is mostly expressed in the sinoatrial (SA) and atrioventricular (AV) nodes which directly connect nodal cells with ..
  33. Zou J, Salarian M, Chen Y, Zhuo Y, Brown N, Hepler J, et al. Direct Visualization of Interaction between Calmodulin and Connexin45. Biochem J. 2017;: pubmed publisher
    ..Here we report the first direct interaction of CaM with Cx45 of g-family in living cells under physiological conditions by monitoring bioluminescence resonance energy transfer (..