HLA-A

Summary

Gene Symbol: HLA-A
Description: major histocompatibility complex, class I, A
Alias: HLAA, HLA class I histocompatibility antigen, A-1 alpha chain, MHC class I antigen HLA-A heavy chain, leukocyte antigen class I-A
Species: human

Top Publications

  1. doi A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
    Jin Xin Bei
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    Nat Genet 42:599-603. 2010
  2. pmc HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
    Jeremiah F Roeth
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 167:903-13. 2004
  3. ncbi Identification of HLA-A2- or HLA-A24-restricted CTL epitopes possibly useful for glypican-3-specific immunotherapy of hepatocellular carcinoma
    Hiroyuki Komori
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Honjo, Japan
    Clin Cancer Res 12:2689-97. 2006
  4. pmc Frequent transmission of cytotoxic-T-lymphocyte escape mutants of human immunodeficiency virus type 1 in the highly HLA-A24-positive Japanese population
    Tae Furutsuki
    Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Virol 78:8437-45. 2004
  5. ncbi HLA-A*26, HLA-B*4002, HLA-B*4006, and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8(+) cytotoxic T lymphocytes
    S Yashiki
    Department of Virology, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    AIDS Res Hum Retroviruses 17:1047-61. 2001
  6. ncbi Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses
    Anke Specht
    Institute of Virology, Universitatsklinikum, 89081 Ulm, Germany
    Virology 373:229-37. 2008
  7. pmc Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef
    Xiaofei Jia
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Nat Struct Mol Biol 19:701-6. 2012
  8. ncbi HLA-A2 down-regulation on primary human macrophages infected with an M-tropic EGFP-tagged HIV-1 reporter virus
    Amanda Brown
    Department of Neurology, Meyer 6 181, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Leukoc Biol 78:675-85. 2005
  9. pmc Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain
    Laura L Baugh
    Y9 206, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Virol 82:9657-67. 2008
  10. pmc HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703
    Philippa C Matthews
    Department of Paediatrics, University of Oxford, Oxford OX1 3SY, United Kingdom
    J Immunol 186:5675-86. 2011

Research Grants

  1. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
  2. PETER R PARHAM; Fiscal Year: 2016
  3. Evolution and Ancestral Functions of a Human MHC Class I Pseudogene, HLA-Y
    ANA S GOYOS; Fiscal Year: 2012
  4. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    Jianming Tang; Fiscal Year: 2012
  5. High-Throughput HLA-Typing: on Raw, Unpurified Cord Blood Samples
    Michael E Hogan; Fiscal Year: 2013
  6. Use of Allogenicity to Stimulate Effector Responses Against Multiple Myeloma
    Christina N Johnson; Fiscal Year: 2013
  7. IDENTIFICATION OF HLA MRNA REGULATORY ELEMENTS
    JANE MCCUTCHEON; Fiscal Year: 2000
  8. PETER R PARHAM; Fiscal Year: 2016
  9. Ellis L Reinherz; Fiscal Year: 2015
  10. Protective roles of CTL responses to HIV-1 associated self epitope
    BETH DEIRDRE JAMIESON KARAVODIN; Fiscal Year: 2010

Detail Information

Publications362 found, 100 shown here

  1. doi A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
    Jin Xin Bei
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    Nat Genet 42:599-603. 2010
    ..61) and rs28421666 (Pcombined=2.49x10(-18), OR=0.67). Our findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules...
  2. pmc HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
    Jeremiah F Roeth
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 167:903-13. 2004
    ..In sum, our evidence suggests that binding of AP-1 to the Nef-MHC-I complex is an important step required for inhibition of antigen presentation by HIV...
  3. ncbi Identification of HLA-A2- or HLA-A24-restricted CTL epitopes possibly useful for glypican-3-specific immunotherapy of hepatocellular carcinoma
    Hiroyuki Komori
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Honjo, Japan
    Clin Cancer Res 12:2689-97. 2006
    ..In addition, we used HLA-A2.1 (HHD) transgenic mice to identify the HLA-A2 (A*0201)-restricted GPC3 epitopes to expand the applications of GPC3-based immunotherapy to the HLA-A2+ HCC patients...
  4. pmc Frequent transmission of cytotoxic-T-lymphocyte escape mutants of human immunodeficiency virus type 1 in the highly HLA-A24-positive Japanese population
    Tae Furutsuki
    Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Virol 78:8437-45. 2004
    ..Thus, HIV-1 with Nef138-10(2F) appears to be a cytotoxic-T-lymphocyte escape mutant and has been transmitted frequently by sexual contact among the highly A24-positive Japanese population...
  5. ncbi HLA-A*26, HLA-B*4002, HLA-B*4006, and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8(+) cytotoxic T lymphocytes
    S Yashiki
    Department of Virology, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    AIDS Res Hum Retroviruses 17:1047-61. 2001
    ..001). These results indicate that HLA-A*26, B*4002, B*4006, and B*4801 alleles predispose to ATL because of the limited recognition of HTLV-1 Tax peptide anchor motifs and epitopes capable of generating anti-HTLV-1 Tax CD8(+) CTLs...
  6. ncbi Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses
    Anke Specht
    Institute of Virology, Universitatsklinikum, 89081 Ulm, Germany
    Virology 373:229-37. 2008
    ....
  7. pmc Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef
    Xiaofei Jia
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Nat Struct Mol Biol 19:701-6. 2012
    ..The structure shows how Nef functions as a clathrin-associated sorting protein to alter the specificity of host membrane trafficking and enable viral evasion of adaptive immunity...
  8. ncbi HLA-A2 down-regulation on primary human macrophages infected with an M-tropic EGFP-tagged HIV-1 reporter virus
    Amanda Brown
    Department of Neurology, Meyer 6 181, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Leukoc Biol 78:675-85. 2005
    ..The impact of Nef on HLA-A2 surface expression in MDM was also confirmed by confocal microscopy. These results suggest that the mechanisms of HLA-A2 down-modulation are similar in primary T cells and macrophages...
  9. pmc Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain
    Laura L Baugh
    Y9 206, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Virol 82:9657-67. 2008
    ..Our results are consistent with an alternative model in which (62)EEEE(65) plays a stabilizing role in the formation of a ternary complex between Nef, the MHC-I cytoplasmic domain, and AP-1...
  10. pmc HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703
    Philippa C Matthews
    Department of Paediatrics, University of Oxford, Oxford OX1 3SY, United Kingdom
    J Immunol 186:5675-86. 2011
    ..In addition, these studies identify a factor contributing to different HIV disease outcomes in individuals expressing HLA-B*5703...
  11. ncbi Genetic susceptibility to nasopharyngeal carcinoma within the HLA-A locus in Taiwanese
    Cheng Chan Lu
    Department of Pathology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    Int J Cancer 103:745-51. 2003
    ..Allele 4 of D6S211 was significantly associated with NPC (OR = 3.97, pc = 0.0042). These results strongly support the hypothesis that genes associated with susceptibility to NPC in the HLA region are within the HLA-A locus...
  12. doi The PTAP sequence within the p6 domain of human immunodeficiency virus type 1 Gag regulates its ubiquitination and MHC class I antigen presentation
    Sabine Hahn
    Institute of Clinical and Molecular Virology, Friedrich Alexander University, 91054 Erlangen, Germany
    J Immunol 186:5706-18. 2011
    ..Although there are no naturally occurring PTAP mutants of HIV-1, mutations of PTAP might enhance the immunogenicity of Gag and, thus, be considered for the improvement of vaccine development...
  13. pmc Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation
    H Akari
    Department of Virology, The University of Tokushima School of Medicine, Tokushima, Tokushima 770 8503, Japan
    J Virol 74:2907-12. 2000
    ....
  14. pmc HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells
    Malinda R Schaefer
    Graduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Pathog 4:e1000131. 2008
    ..The requirement for redundant motifs with distinct roles supports a model in which Nef exists in multiple conformational states that allow access to different motifs, depending upon which cellular target is bound by Nef...
  15. doi Distributions of human leukocyte antigen-A, -B, and -DRB1 alleles and haplotypes based on 46,915 Taiwanese donors
    Meng Jiun Lai
    Department of Laboratory of Medicine and Biotechnology, College of Medicine, Buddhist Tzu Chi University, Hualien, Taiwan
    Hum Immunol 71:777-82. 2010
    ..We believe that our findings in this study may provide useful information in search for HLA-matched donors for patients...
  16. pmc Disparate associations of HLA class I markers with HIV-1 acquisition and control of viremia in an African population
    Wei Song
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e23469. 2011
    ..Here we report on the impact of established and potential new HLA class I determinants of heterosexual HIV-1 acquisition in the HIV-1-exposed seronegative (HESN) partners of serodiscordant Zambian couples...
  17. pmc Immune selection in vitro reveals human immunodeficiency virus type 1 Nef sequence motifs important for its immune evasion function in vivo
    Martha J Lewis
    Department of Medicine, Division of Infectious Diseases, Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Virol 86:7126-35. 2012
    ..Overall, these data demonstrate that CTL pressure exerts a strong purifying selective pressure for MHC-I downregulation and identifies novel functional motifs present in Nef sequences in vivo...
  18. pmc Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationships
    Jianming Tang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e9629. 2010
    ..Immunogenetic research has established various human genetic factors, especially human leukocyte antigen (HLA) variants, as independent determinants of VL set-point...
  19. pmc Comprehensive analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci and squamous cell cervical cancer risk
    Margaret M Madeleine
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Res 68:3532-9. 2008
    ..Thus, certain co-occurring alleles may be markers of disease risk that have clinical value as biomarkers for targeted screening or development of new therapies...
  20. pmc HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation
    Ushani S Rajapaksa
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 109:13353-8. 2012
    ..We propose that the relative resistance to Nef-mediated down-regulation by the cytoplasmic domains of HLA-B compared with HLA-A contributes to the better control of HIV-1 infection associated with HLA-B-restricted CTLs...
  21. pmc HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes
    J D Weissman
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:11601-6. 1998
    ..Thus, Tat repression of MHC class I transcription would be one mechanism by which HIV avoids immune surveillance...
  22. pmc Proline 78 is crucial for human immunodeficiency virus type 1 Nef to down-regulate class I human leukocyte antigen
    Takeshi Yamada
    Division of Infectious Diseases, Advanced Clinical Research Center, The University of Tokyo, Japan
    J Virol 77:1589-94. 2003
    ..Analyses of a series of PRD substitution mutants indicated that, because the substitution of Pro78 with Ala abolished down-regulation of HLA-I but not of CD4, Pro78 is important for HLA-I down-regulation in T lymphocytes...
  23. ncbi Cutting Edge: Epitope-dependent effect of Nef-mediated HLA class I down-regulation on ability of HIV-1-specific CTLs to suppress HIV-1 replication
    Hiroko Tomiyama
    Division of Viral Immunology, Center for AIDS Research, Kumamoto University, 2 2 2 Honjo, Kumamoto 860 0811, Japan
    J Immunol 174:36-40. 2005
    ..The difference of the ability between these two types of CTLs may result from the difference of the number of HLA class I epitope complex on the surface of NL-432-infected CD4+ T cells...
  24. pmc Transcription of preintegrated HIV-1 cDNA modulates cell surface expression of major histocompatibility complex class I via Nef
    Richard D Sloan
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, H3T 1E2 Canada
    J Virol 85:2828-36. 2011
    ..Hence, the capacity of HIV-1 to modulate MHC-I is not linked to its ability to integrate. Thus, Nef-mediated evasion of host immune responsiveness might be attributable, in part at least, to transcription from unintegrated viral DNA...
  25. ncbi Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme
    Jianming Tang
    Department of Medicine, University of Alabama at Birmingham, 1665 University Boulevard, RPHB Room 220A, Birmingham, AL 35294 0022, USA
    Cancer Epidemiol Biomarkers Prev 14:2040-4. 2005
    ..B*07 and the B*07-Cw*07 haplotype are much more common in Caucasians than other ethnic groups in the U.S., which may partially explain the higher incidence of glioblastoma multiforme in Caucasians...
  26. pmc HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection
    Karen A McAulay
    Clinical and Basic Virology Laboratory, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, Summerhall, Edinburgh, United Kingdom
    J Clin Invest 117:3042-8. 2007
    ....
  27. doi Role of Nef in primate lentiviral immunopathogenesis
    F Kirchhoff
    Institute of Virology, University of Ulm, 89081 Ulm, Germany
    Cell Mol Life Sci 65:2621-36. 2008
    ..This evolutionary loss of a specific Nef function may contribute to the high virulence of HIV-1 in humans...
  28. pmc Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection
    Akihisa Shimizu
    Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Sci Rep 3:3097. 2013
    ..TCR from Y135F- or dually-specific CTL had unique mode of binding to the mutant epitope. Y135F has been reported as a processing mutant but CTL carrying structurally adequate TCR can be found in the patients. ..
  29. ncbi HLA typing in a Kenyan cohort identifies novel class I alleles that restrict cytotoxic T-cell responses to local HIV-1 clades
    Thomas G Bird
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK
    AIDS 16:1899-904. 2002
    ..To investigate HLA class I allele frequencies in a Kenyan commercial sex worker (CSW) cohort, and to examine HIV-1 specific cytotoxic T lymphocyte (CTL) responses directed against epitopes derived from locally prevalent clade A virus...
  30. doi Human leukocyte antigen profile in HIV-1 infected individuals and AIDS patients from Chongqing, China
    Xia Huang
    Department of Epidemiology, Third Military Medical University, Chongqing, China
    Microbiol Immunol 53:512-23. 2009
    ..However, HIV-1 infected individuals who have B*5801 alleles, A*3303/1-B*5801 haplotype and are heterozygous for Bw4-Bw6 are more likely to be resistant to progression of AIDS in this Chinese population...
  31. pmc Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes
    Kati Lipponen
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Diabetes 59:3253-6. 2010
    ..To test this hypothesis we analyzed the role of HLA class I and class II gene polymorphisms in the progression from diabetes-associated autoimmunity to clinical disease...
  32. pmc The natural killer cell cytotoxic function is modulated by HIV-1 accessory proteins
    Bharatwaj Sowrirajan
    Department of Immunology and Microbiology, Rush University Medical Center, 1735 West Harrison St, Chicago, IL 60612, USA
    Viruses 3:1091-111. 2011
    ..This review will focus on the mechanisms through which the HIV-1 accessory proteins modulate their respective ligands, and its implication for NK cell killing of HIV-infected cells...
  33. pmc HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis
    Boel Brynedal
    Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 2:e664. 2007
    ..These findings imply complex autoimmune mechanisms involving both the regulatory and the effector arms of the immune system in the triggering of MS...
  34. ncbi A human killer inhibitory receptor specific for HLA-A1,2
    C Döhring
    Basel Institute for Immunology, Switzerland
    J Immunol 156:3098-101. 1996
    ..Here we demonstrate that a member of the KIR cDNA family, designated NKAT4, encodes a 70-kDa receptor specific for HLA-A3...
  35. ncbi Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids
    Y H Ding
    Department of Molecular and Cellular Biology, Harvard University, Howard Hughes Medical Institute, Cambridge, Massachusetts 02138, USA
    Immunity 8:403-11. 1998
    ..The existence of a structurally similar diagonal binding mode for TCRs favors mechanisms based on the formation of geometrically defined supramolecular assemblies for initiating signaling...
  36. pmc Different effects of Nef-mediated HLA class I down-regulation on human immunodeficiency virus type 1-specific CD8(+) T-cell cytolytic activity and cytokine production
    Hiroko Tomiyama
    Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Honjo, Kumamoto 860 0811, Japan
    J Virol 76:7535-43. 2002
    ..These findings may account for the mechanism whereby HIV-1-specific CD8(+) T cells are able to partially but not completely control HIV-1 replication in vivo...
  37. pmc The HLA class I A locus affects susceptibility to type 1 diabetes
    Janelle A Noble
    Children s Hospital, Oakland Research Institute, Oakland, CA 94609, USA
    Hum Immunol 63:657-64. 2002
    ..Our results suggest an important role for class I antigens in modulating susceptibility to type 1 diabetes...
  38. ncbi HIV Nef: role in pathogenesis and viral fitness
    Kevin K Ariën
    HIVLab, Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, 4BlokA, B 9000 Gent, Belgium
    Curr HIV Res 6:200-8. 2008
    ..Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness...
  39. pmc Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa
    Zabrina Brumme
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, USA
    Clin Infect Dis 49:956-64. 2009
    ....
  40. pmc Association of human leukocyte antigens with nasopharyngeal carcinoma in high-risk multiplex families in Taiwan
    Kelly J Yu
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Hum Immunol 70:910-4. 2009
    ..This finding requires replication in larger studies...
  41. doi HLA-A, -B, -C, -DQB1, and -DRB1,3,4,5 allele and haplotype frequencies in the Costa Rica Central Valley Population and its relationship to worldwide populations
    Esteban Arrieta-Bolaños
    Centro de Investigaciones en Hematología y Trastornos Afines CIHATA, Hospital San Juan de Dios, San Jose, Costa Rica
    Hum Immunol 72:80-6. 2011
    ..Results showed that populations genetically closest to the CCVP are a Mestizo urban population from Venezuela, and another one from Guadalajara, Mexico...
  42. pmc Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix
    Lillian S Kuo
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y9 206, Dallas, TX 75390, USA
    Retrovirology 9:47. 2012
    ..Further, mutation of the non-motif "X" residues, (Q73, V74, and L75) would give altered patterns of inhibition for different Nef/SH3 domain protein interactions...
  43. ncbi HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway
    S A Swann
    Departments of Medicine and Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Virology 282:267-77. 2001
    ..We propose that Nef diverts MHC-1 proteins into a PI 3-kinase-dependent transport pathway that prevents expression on the cell surface...
  44. pmc Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells
    Matthew R Kasper
    Department of Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Virol 77:3041-9. 2003
    ....
  45. ncbi The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner
    Nicoletta Casartelli
    Division of Immunology and Infectious Disease, Children s Hospital Bambino Gesu, Piazza S Onofrio 4, 00165 Rome, Italy
    J Gen Virol 87:2291-6. 2006
    ..In addition, it is demonstrated that P72 and P75, and thus the SH3-binding capacity, are fully dispensable for Nef activity on MHC-I...
  46. ncbi HLA-A, -B, -C, and -DRB1 allele frequencies in Cuban individuals with antecedents of dengue 2 disease: advantages of the Cuban population for HLA studies of dengue virus infection
    Beatriz Sierra
    Institute of Tropical Medicine Pedro Kouri, WHO Collaborator Centre for Viral Diseases, Havana, Cuba
    Hum Immunol 68:531-40. 2007
    ....
  47. ncbi Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium
    Michael J Chao
    Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Hum Mol Genet 16:1951-8. 2007
    ..The frequency of allelic associations not being replicated emphasizes the requirement for constructing multi-locus haplotypes in dissecting associations in regions of tight LD...
  48. pmc HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load
    Christine M Rousseau
    Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 82:6434-46. 2008
    ....
  49. pmc HLA-class I markers and multiple sclerosis susceptibility in the Italian population
    L Bergamaschi
    Department of Medical Sciences and Interdisciplinary Research Center of Autoimmune Diseases, University of Eastern Piedmont, Via Solaroli 17, Novara, Italy
    Genes Immun 11:173-80. 2010
    ..In the absence of A*02, Cw*05 behaved as a risk factor, particularly in combination with DRB1*03 (OR=3.89, P=0.0006), indicating that Cw*05 might be a marker of protective or risk haplotypes, respectively...
  50. pmc Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants?
    Philip Mwimanzi
    Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada
    Viruses 4:1711-30. 2012
    ....
  51. ncbi HLA-A*02 subtype distribution in Caucasians from northern Italy: identification of A*0220
    K Fleischhauer
    Department of Biology and Biotechnology DIBIT, Istituto Scientifico H S Raffaele, Milano, Italy
    Tissue Antigens 48:673-9. 1996
    ..The findings of this study have implications for the selection of HLA-A*02+ donors in unrelated bone marrow transplantation and of patients for specific immuno-therapy with HLA-A*02 restricted peptide vaccines...
  52. ncbi Differential expression of HLA-A*02 subtypes in Colombian Blacks and Mestizos
    K Fleischhauer
    Department of Biology and Biotechnology, Istituto Scientifico H S Raffaele, Milano, Italy
    Tissue Antigens 51:204-9. 1998
  53. pmc Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation
    S Le Gall
    Unité Rétrovirus et Transfert Génétique, URA CNRS 1930, France
    J Virol 74:9256-66. 2000
    ..Moreover, trafficking of A2-endo was still affected by the viral protein, indicating additive effects of prototypic signals and Nef. Therefore, distinct trafficking pathways regulate clathrin-dependent and Nef-induced MHC-I modulation...
  54. ncbi HLA class I and class II allele and haplotype diversity in Martinicans
    O Bera
    Laboratoire de Virologie Immunologie, CHU de Fort de France, Martinique
    Tissue Antigens 57:200-7. 2001
    ....
  55. ncbi HLA polymorphism in the Murcia population (Spain): in the cradle of the archaeologic Iberians
    M Muro
    Service of Immunology, University Hospital Virgen de la Arrixaca, Murcia, Spain
    Hum Immunol 62:910-21. 2001
    ..Thus, Murcian population seems to belong to the European genetic pool, revealing a lesser genetic distance with the North Africans and the rest of populations from the Iberian Peninsula...
  56. ncbi Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci
    K Cao
    Department of Oncology, Georgetown University, Washington, DC, USA
    Tissue Antigens 63:293-325. 2004
    ....
  57. ncbi Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome
    Neal Flomenberg
    Department of Medicine and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 104:1923-30. 2004
    ..When clinical circumstances allow, high-resolution class I typing may help optimize donor selection and improve outcome...
  58. ncbi HLA class I and II polymorphisms in Azores show different settlements in Oriental and Central islands
    H Spinola
    Human Genetics Laboratory, University of Madeira, Funchal, Portugal
    Tissue Antigens 66:217-30. 2005
    ..The Central group of islands on the contrary clearly shows an influence of north Europeans (most probably derived from a well-documented Flemish settlement), with much less affinity to mainland Portugal...
  59. ncbi Influence of HLA alleles on shedding of Kaposi sarcoma-associated herpesvirus in saliva in an African population
    Khaled R Alkharsah
    Institute of Virology, Hannover Medical School, Hannover, 30625, Germany
    J Infect Dis 195:809-16. 2007
    ....
  60. ncbi [HLA-A, B, and DRB1 gene polymorphisms in Mongol ethnic group of Inner Mongolia, China]
    Chun Mei Shen
    The Key Laboratory of National Ministry of Health for Forensic Sciences, Xi an 710061, China
    Yi Chuan 30:164-8. 2008
    ..The most frequent HLA A-B, B-DRB1, and A-B-DRB1 haplotypes were HLA-A*02-B*46 (0.0510), HLA-A*02-B*13 (0.0495), HLA-A*02-B*51 (0...
  61. doi Human leukocyte antigen-A, -B, and -DRB1 haplotypes of cord blood units in the Tzu Chi Taiwan Cord Blood Bank
    Shu Hui Wen
    Department of Public Health, College of Medicine, Buddhist Tzu Chi University, Hualien 970, Taiwan
    Hum Immunol 69:430-6. 2008
    ....
  62. pmc Human leukocyte antigen class I genotypes in relation to heterosexual HIV type 1 transmission within discordant couples
    Jianming Tang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 181:2626-35. 2008
    ..Thus, HLA class I gene products not only mediate HIV-1 pathogenesis and evolution but also influence heterosexual HIV-1 transmission...
  63. pmc HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3349-58. 2009
    ....
  64. doi HLA class I allele and haplotype diversity in Ugandans supports the presence of a major east African genetic cluster
    G H Kijak
    Division of Retrovirology, US Military HIV Research Program Henry M Jackson Foundation, Rockville, MD 20850, USA
    Tissue Antigens 73:262-9. 2009
    ..The congruence of major alleles in different populations would permit consideration of East Africa as an integrated setting when designing and evaluating much needed malaria, tuberculosis, and AIDS vaccines...
  65. pmc Association between protective and deleterious HLA alleles with multiple sclerosis in Central East Sardinia
    Roberta Pastorino
    Dipartimento di Scienze Sanitarie Applicate e Psicocomportamentali, Universita di Pavia, Pavia, Italy
    PLoS ONE 4:e6526. 2009
    ..Also, the analysis of SNPs suggests that there are other HLA genes involved in MS, but replication is needed. This opens up new perspective on the study of MS...
  66. ncbi The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes
    A M Wan
    J Immunol 137:3671-4. 1986
    ....
  67. ncbi The detailed distribution of HLA-A, B, C antigens in normal human organs
    A S Daar
    Transplantation 38:287-92. 1984
    ..We conclude, therefore, that class I antigens are not ubiquitous, as previously thought...
  68. pmc The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
    M E Greenberg
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    EMBO J 17:2777-89. 1998
    ....
  69. pmc Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking
    A Mangasarian
    Department of Genetics and Microbiology, University of Geneva, Geneva, Switzerland
    J Virol 73:1964-73. 1999
    ....
  70. ncbi The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
    G B Cohen
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Immunity 10:661-71. 1999
    ..These results suggest that subpopulations of CTL and NK cells may be uniquely suited for combating HIV...
  71. ncbi Frequencies of HLA-A2 alleles in five U.S. population groups. Predominance Of A*02011 and identification of HLA-A*0231
    J M Ellis
    Department of Microbiology, Georgetown University Medical Center, Washington, DC, USA
    Hum Immunol 61:334-40. 2000
    ..9%) were present in a large percentage of African-Americans. Only 13 of the 31 known HLA-A2 alleles were observed in the study. The allelic distributions reflected statistically significant differences among population groups...
  72. ncbi Association between the ancestral haplotype HLA A30B18DR3 and multiple sclerosis in central Sardinia
    P P Bitti
    Centro Tipizzazione Tissutale, Ospedale San Francesco, Nuoro, Italy
    Genet Epidemiol 20:271-83. 2001
    ..11)...
  73. ncbi No association of the HLA-A2 allele with Alzheimer's disease
    L Araria-Goumidi
    INSERM U 508, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Cedex, Lille, France
    Neurosci Lett 335:75-8. 2002
    ..Moreover, no effect was observed when we stratified the case-control sample on gender, age of onset or presence of an APOE epsilon4 allele. We conclude that HLA-A2 allele is not a major risk factor for sporadic AD...
  74. ncbi Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan
    Allan Hildesheim
    Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rm 7062, Rockville, MD 20852, USA
    J Natl Cancer Inst 94:1780-9. 2002
    ..We used high-resolution HLA genotyping in a case-control study in Taiwan to systematically evaluate the association between various HLA alleles and NPC...
  75. ncbi Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection
    Chenglong Liu
    School of Public Health, University of California, Los Angeles, CA 90095, USA
    J Infect Dis 187:1404-10. 2003
    ..In multivariate logistic analysis, only the A*0205 subgroup (OR, 5.56; 95% CI, 1.34-23.10; P=.018) and the TAP2 Ala665 (OR, 2.22; 95% CI, 1.28-3.84; P=.005) were associated with resistance...
  76. ncbi HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication
    Alison L Greenway
    Macfarlane Burnet Institute for Medical Research and Public Health, Cnr Commercial and Punt Roads, Melbourne, Victoria 3004, Australia
    J Biosci 28:323-35. 2003
    ....
  77. pmc Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors
    Frank Kirchhoff
    Department of Virology, Universitatsklinikum, 89081 Ulm, Germany
    J Virol 78:6864-74. 2004
    ....
  78. ncbi [HLA-A, B, DRB1 gene polymorphism of Beijing population was studied by high-resolution polymerase chain reaction sequence-based typing]
    Ya Jun Deng
    Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:103-6. 2006
    ..To investigate the gene polymorphism of human leukocyte antigen (HLA)-A, B, DRB1 loci in the population of Beijing region, and research on the application feasibility of polymerase chain reaction sequence-based typing (PCR-SBT) method...
  79. ncbi Functional characterization of HIV-1 Nef mutants in the context of viral infection
    Oliver T Fackler
    Department of Virology, University of Heidelberg, INF 324, D 69120 Heidelberg, Germany
    Virology 351:322-39. 2006
    ..The results emphasize that multiple activities govern Nef's effects on HIV replication and argue against a role of virion incorporation for Nef's activity as pathogenicity factor...
  80. ncbi Combination of HLA-A24, -DQA1*03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell function
    Koji Nakanishi
    Department of Endocrinology and Metabolism, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo 105 8470, Japan
    Diabetes 55:1862-8. 2006
    ....
  81. ncbi Genetic link between Chaoshan and other Chinese Han populations: Evidence from HLA-A and HLA-B allele frequency distribution
    Sheng Ping Hu
    Center for Molecular Biology and Forensic Genetics Laboratory, Shantou University Medical College, Shantou, Guangdong 515031, People s Republic of China
    Am J Phys Anthropol 132:140-50. 2007
    ..The different genetic background between northern and southern China may explain, at least partially, the prevalence of NPC among southern Chinese...
  82. ncbi Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese
    Mayumi Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi, Kyoto, Japan
    Am J Ophthalmol 143:367-8. 2007
    ..To investigate the association between HLA class I antigens and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with ocular complications in Japanese...
  83. ncbi Polymorphism of HLA class I genes in Meizhou Han population of Guangdong, China
    S Chen
    State Key Laboratory for Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, Department of Biochemistry, College of Life Sciences, Sun Yat Sen Zhongshan University, Guangzhou, Guangdong, 510275 China
    Int J Immunogenet 34:131-6. 2007
    ..4%). Phylogenetic tree based on HLA class I allele frequencies genetically suggested that Meizhou Han has an affinity to southern Asian populations. The result may also reflect an admixture of Han and ethnic minorities of southern China...
  84. ncbi Association of human leukocyte antigen and T cell message with human papillomavirus 16-positive cervical neoplasia in Japanese women
    M Saito
    Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical School, Saitama, Japan
    Int J Gynecol Cancer 17:1314-21. 2007
    ..Accordingly, a specific MHC class II haplotype, DRB1*0901-DQB1*03032, may be a risk factor for cervical carcinoma in the Japanese population...
  85. pmc HLA class I and II gene polymorphisms in Stevens-Johnson syndrome with ocular complications in Japanese
    Mayumi Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Mol Vis 14:550-5. 2008
    ..In this study, we investigated the association between HLA class II antigens in addition to HLA class I antigens and SJS/TEN...
  86. doi HIV-1 accessory proteins--ensuring viral survival in a hostile environment
    Michael H Malim
    Department of Infectious Diseases, King s College London School of Medicine, 2nd Floor, Borough Wing, Guy s Hospital, London Bridge, London, SE1 9RT, UK
    Cell Host Microbe 3:388-98. 2008
    ..Broadly speaking, the HIV-1 accessory proteins modify the local environment within infected cells to ensure viral persistence, replication, dissemination, and transmission...
  87. pmc Genetic polymorphisms at HLA-A, -B, and -DRB1 loci in Han population of Xi'an city in China
    Chunmei Shen
    Department of Forensic Medicine, School of Medicine, Xi an Jiaotong University, Xi an, 710061 Shaanxi, P R China
    Croat Med J 49:476-82. 2008
    ..To determine genetic polymorphisms at human leukocyte antigen (HLA)-A, -B, and -DRB1 loci in Han population of Xi'an city in China...
  88. pmc HLA-A, -B, -C, and -DRB1 allele and haplotype frequencies distinguish Eastern European Americans from the general European American population
    S J Mack
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Tissue Antigens 73:17-32. 2009
    ....
  89. doi Role of HIV-1 Nef protein for virus replication in vitro
    Abhay Jere
    Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Microbes Infect 12:65-70. 2010
    ..This review summarizes and organizes current knowledge of HIV-1 Nef with respect to this particularly virological activity for understanding the basis of its in vivo function...
  90. pmc Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs
    Wei Song
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 4:e7157. 2009
    ..In a previous study, several HLA-B and HLA-C alleles and haplotypes were positively or negatively associated with the occurrence and prognosis of glioblastoma multiforme (GBM)...
  91. doi HLA alleles and haplotypes distribution in Dai population in Yunnan province, Southwest China
    L Shi
    Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China
    Tissue Antigens 75:159-65. 2010
    ..Our results showed that the Dai population has unique HLA characteristic that are most closely related to the Southeastern Asia group and similar to the Kam-Tai speaking populations in China and Thailand...
  92. pmc Haplotype-dependent HLA susceptibility to nasopharyngeal carcinoma in a Southern Chinese population
    M Tang
    Laboratory of Genomic Diversity National Cancer Institute Frederick, Frederick, MD, USA
    Genes Immun 11:334-42. 2010
    ..42 (P<0.0001). The overall high frequency of NPC-susceptible HLA factors in the Guangxi population is likely to have contributed to the high-NPC incidence in this region...
  93. doi Allelic diversity and haplotype structure of HLA loci in the Chinese Han population living in the Guanzhong region of the Shaanxi province
    Chun Mei Shen
    Key Laboratory of Environment and Gene Related to Diseases, Xi an Jiaotong University, Ministry of Education, Xi an, Shaanxi, People s Republic of China
    Hum Immunol 71:627-33. 2010
    ..54%), DRB1*09 (13.18%) and DRB1*04 (11.21%). Three-loci haplotype analysis revealed that HLA A*30- B*13- DRB1*07 (4.11%), A*02 -B*46 -DRB1*09 (2.57%) and A*33 -B*58 -DRB1*17 (1...
  94. pmc HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma
    Henrik Hjalgrim
    Department of Epidemiology Research, Statens Serum Institut, DK 23005, Copenhagen, Denmark
    Proc Natl Acad Sci U S A 107:6400-5. 2010
    ..Our findings suggest that HLA class I-restricted EBV-specific cytotoxic T-cell responses and events in the early immune response to EBV infection in IM play critical roles in the pathogenesis of EBV-related HL...
  95. pmc Maternal human leukocyte antigen A*2301 is associated with increased mother-to-child HIV-1 transmission
    Romel D Mackelprang
    Departments of 1Epidemiology, 2Medicine, 3Global Health, and 4Biostatistics, University of Washington, Seattle, Washington 5Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, National Cancer Institute at Frederick, Maryland and 6Department of Paediatrics, University of Nairobi, Kenya
    J Infect Dis 202:1273-7. 2010
    ..26-7.51; P =.01; Pcorr is not significant). That maternal HLA-A*2301 was associated with transmission independent of plasma HIV-1 RNA levels suggests that HLA may alter infectivity through mechanisms other than influencing HIV-1 load...
  96. pmc HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans
    Mark McCormack
    Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland
    N Engl J Med 364:1134-43. 2011
    ..The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations...
  97. pmc The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection
    Jolien Vermeire
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Belgium
    Curr HIV Res 9:474-89. 2011
    ..Hereby we aim to contribute to a better understanding of this highly conserved and therapeutically attractive Nef function...
  98. ncbi Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
    O Schwartz
    Laboratoire Rétrovirus et Transfert Génétique, Unité de Recherche Associée CNRS 1157, Paris, France
    Nat Med 2:338-42. 1996
    ..The stimulation of MHC-I endocytosis by Nef represents a previously undocumented viral mechanism for evading the immune response...
  99. ncbi The dileucine-based sorting motif in HIV-1 Nef is not required for down-regulation of class I MHC
    N L Riggs
    Department of Medicine, University of California, San Diego, CA, USA
    Virology 258:203-7. 1999
    ..The data also suggest that protein interactions mediated by the acidic domain, rather than by the dileucine motif, may contribute to this function of Nef...
  100. pmc HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
    V Piguet
    Department of Genetics and Microbiology, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland
    Nat Cell Biol 2:163-7. 2000
    ..These results support a model in which Nef relocalizes MHC-I by acting as a connector between MHC-I's cytoplasmic tail and the PACS-1-dependent protein-sorting pathway...
  101. ncbi Differential expression of human major histocompatibility class I loci: HLA-A, -B, and -C
    D R Johnson
    Department of Pathology and the Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Hum Immunol 61:389-96. 2000
    ..Differential expression of these HLA class I loci may contribute to cell-type dependent immune reactions by preferentially presenting distinct peptides to T cells...

Research Grants71

  1. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
    ..By studying these rapidly evolving immune system components in closely related species of non-human primate we will gain new insight and greater understanding of the human system and its contribution to human health and survival. ..
  2. PETER R PARHAM; Fiscal Year: 2016
    ..This project will determine the variability of these genes in the human population and how these differences affect their function. ..
  3. Evolution and Ancestral Functions of a Human MHC Class I Pseudogene, HLA-Y
    ANA S GOYOS; Fiscal Year: 2012
    ..Results obtained from this study will help in the understanding of the consequences of MHC variation on the human immune response and in disease resistance and susceptibility. ..
  4. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    Jianming Tang; Fiscal Year: 2012
    ....
  5. High-Throughput HLA-Typing: on Raw, Unpurified Cord Blood Samples
    Michael E Hogan; Fiscal Year: 2013
    ..That "Raw Guthrie Card" HLA-Typing would then be compared, in terms of accuracy &cost, to that obtained by current methods of HLA-Typing on purified DNA. ..
  6. Use of Allogenicity to Stimulate Effector Responses Against Multiple Myeloma
    Christina N Johnson; Fiscal Year: 2013
    ..Ultimately, this project seeks to contribute to the knowledge base currently being used to develop immunotherapies for diseases such as MM, specifically in populations which demonstrate well-documented health disparities. ..
  7. IDENTIFICATION OF HLA MRNA REGULATORY ELEMENTS
    JANE MCCUTCHEON; Fiscal Year: 2000
    ..These studies will increase our understanding of immune regulation. ..
  8. PETER R PARHAM; Fiscal Year: 2016
    ....
  9. Ellis L Reinherz; Fiscal Year: 2015
    ..It has general application to other highly mutable viral pathogens affecting mankind. ..
  10. Protective roles of CTL responses to HIV-1 associated self epitope
    BETH DEIRDRE JAMIESON KARAVODIN; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The experiments could benefit HIV-1 infected individuals by providing a unique avenue for the development of therapeutic strategies. ..
  11. CD8 T Cell Reactivity to IGRP as an Autoimmunity Marker in Type 1 Diabetes
    Teresa Dilorenzo; Fiscal Year: 2007
    ..Tests may also be developed to monitor destructive T cell activity in patients undergoing treatment, so that doctors will be able to know if the treatments are working. [unreadable] [unreadable] [unreadable]..
  12. Decryption of KIR genetics and function in early HIV-1 infection
    Jason David Barbour; Fiscal Year: 2013
    ..We aim (1) To describe the KIR gene cluster, and the HLA A, B and C loci in 1300 recently infected adults;(2) To chart KIR and HLA genetics to NK effector function in these ..
  13. Derivation and Transplantation of Histocompatible Pluripotent Stem Cells
    David W Russell; Fiscal Year: 2010
    ..abstract_text> ..
  14. Effie W Petersdorf; Fiscal Year: 2016
    ..In this way, patients can be cured of their cancer and live longer healthier lives. ..
  15. GENETIC ANALYSIS OF ALTERED IMMUNITY IN CELIAC DISEASE
    JOSEPH MICHALSKI; Fiscal Year: 1990
    ..parameters previously found to be associated with the HLA-B8/DR3 haplotype, serologically detected alleles of the HLA A, B and C loci, and DNA polymorphisms representing alleles of the HLA-DR, DQ and DP loci...
  16. HCV resolution correlates with patterned KIR expressions on lymphocytes.
    James C Ryan; Fiscal Year: 2013
    ..These studies also will help to identify KIR as attractive drug targets for pharmacologic antiviral therapies. ..
  17. HIV Evasion of NK Cells in Lymph Nodes
    Allan R Tenorio; Fiscal Year: 2010
    ..These insights will point the way towards treatment strategies that will enhance the immune system's ability to control HIV. ..
  18. High Resolution Multiplexed DNA reverse-SSO Typing Assay
    Jar How Lee; Fiscal Year: 2007
    ..Following validation testing and regulatory clearance, a complete line of superior HLA and KIR typing products will be available to the NMDP and HLA laboratories. ..
  19. HLA I DETERMINANTS OF CTL RESPONSE TO HIV INFECTION
    Frederick Lee; Fiscal Year: 2003
    ..However, these studies have only been performed in persons who are HLA A 0201-positive, and have only been performed for two peptide epitopes...
  20. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    REBECCA CYNTHIA OBENG; Fiscal Year: 2010
    ..We hope to identify new breast cancer antigens which are more effective as immunotherapeutic agents for breast cancer patients. ..
  21. Synethic protein and peptide assemblies as novel adjuvants and vaccines
    Joel H Collier; Fiscal Year: 2012
    ....
  22. Development & Characterization of Tyrosinase Epitope Specific TCR Transgenic Mice
    Shikhar Mehrotra; Fiscal Year: 2010
    ..Successful completion of this proposal would provide us information about the feasibility of using this TIL1383i TCR in T cell adoptive immunotherapy protocols. ..
  23. Paul Nghiem; Fiscal Year: 2016
    ....
  24. Peter Cresswell; Fiscal Year: 2016
    ..This proposal seeks to understand in detail how the HLA-peptide complexes, critical for recognition by the T cells, are made. ..
  25. ANTIGENIC DETERMINANTS ON HLA-B7 AND -A2
    Victor H Engelhard; Fiscal Year: 2012
    ..The goal of this proposal is to establish this relationship more directly, and to test one of these antigens for its ability to stimulate a cancer specific immune response in melanoma patients. ..
  26. LAMIN A PROGERIA MUTATIONS AND NUCLEAR FUNCTION
    Robert D Goldman; Fiscal Year: 2010
    ..These collective studies will provide important insights into how hLA mutations cause the defects seen in progeria. ..
  27. RICHARD ANDREW SPRITZ; Fiscal Year: 2016
    ..It is our goal that the resultant biological knowledge will provide the basis for new approaches to treatment and even prevention of GV and associated autoimmune diseases. ..
  28. Resistance to apoptosis in clinical melanoma gene therapy
    Ali Jazirehi; Fiscal Year: 2012
    ..T lymphocytes engineered to express this high affinity TCR are highly cytotoxic towards HLA A*0201/ MART-positive melanoma targets, release type I cytokines and are biologically very active when administered ..
  29. June Kan-Mitchell; Fiscal Year: 2015
    ..These studies will provide insights into the role of HLA-E-restricted NK and CD8+ T cell surveillance in HIV infection. ..
  30. Jordan S Pober; Fiscal Year: 2014
    ..Successful completion of these aims may lead to new preventative therapies that target GA. ..
  31. ISABELLE CAROLINE LE POOLE; Fiscal Year: 2014
    ....
  32. RICHARD ANDREW SPRITZ; Fiscal Year: 2014
    ....
  33. Edward Barker; Fiscal Year: 2016
    ..Knowledge of these mechanisms will undoubtedly lead to novel therapeutic interventions aimed at restoring the effectiveness of the NK compartment during HIV- 1 infection. ..
  34. Vpu inhibits NK cell function through down regulation of NTB-A
    Edward Barker; Fiscal Year: 2011
    ..Knowledge of these mechanisms will undoubtedly lead to novel therapeutic interventions aimed at restoring the effectiveness of the NK compartment during HIV-1 infection. ..
  35. Teresa P DiLorenzo; Fiscal Year: 2015
    ....
  36. HIV-1 THERAPEUTICS AND DRUG RESISTANCE
    Daniel R Kuritzkes; Fiscal Year: 2010
    ..interruption phase of therapeutic vaccine trial (ACTG protocol A5197);and 3) to determine the influence of the HLA A*0201 allele on the rate of reversion of protease inhibitor resistance mutations in subjects interrupting a failing ..
  37. Mucosal Reovirus-Adenovirus Vaccines Against HIV-1
    Michael A Barry; Fiscal Year: 2011
    ..This project will provide vaccine efficacy and safety data for these three Ad vaccine approaches in mice as a precursor to testing in rhesus macaques and in humans. ..
  38. T Cell Tolerance by DEC-205-mediated Islet Antigen Delivery to Dendritic Cells
    Teresa P DiLorenzo; Fiscal Year: 2010
    ..Aim 1b. To test the efficacy of antigen targeting to DCs for the prevention of T1D in HLAA* 0201-transgenic NOD mice. Aim 2a...
  39. IMMUNOGENETICS OF MARROW ALLOGRAFTING
    John Hansen; Fiscal Year: 1992
    ..The research question addressed in Project 6 is whether the microvariants defined by individual HLA alleles have a significant impact on GVHD...
  40. Immunological memory to malaria liver stage antigens
    James Kazura; Fiscal Year: 2006
    ..abstract_text> ..
  41. Kerry S Campbell; Fiscal Year: 2014
    ....
  42. RHEUMATOID ARTHRITIS
    C Kwoh; Fiscal Year: 1993
    ....
  43. CLASS I MHC GENES EXPRESSED BY HUMAN TROPHOBLAST CELLS
    JOAN HUNT; Fiscal Year: 1999
    ..We expect the results of this research to shed considerable light on crucial issues of HLA-related fertility and reproduction. ..
  44. CORNEAL TRANSPLANTATION STUDIES
    Maureen Maguire; Fiscal Year: 1992
    ..This application is for the Coordinating Center. The Coordinating Center plays and integral role in design development, implementation, and analysis in multicenter studies...
  45. CTL DEFINED ANTIGENS IN NON SMALL CELL LUNG CANCER
    John Yannelli; Fiscal Year: 2001
    ..These attempts to generate specific CTL in NSCLC will add greatly to our knowledge base of the immunological response to this disease as well as provide critical reagents for vaccine or cellular immunotherapy protocols. ..
  46. IMPLICATIONS OF HLA POLYMORPHISM FOR DONOR RECRUITMENT
    Motomi Mori; Fiscal Year: 2000
    ....
  47. NOVEL STRATEGIES FOR THE IMMUNOTHERAPY OF COLON CANCER
    Ralph Reisfeld; Fiscal Year: 2003
    ..The achievement of this proposal's objectives should lead to the design of effective DNA vaccines based on rational immunological principles that may ultimately lead to the improved treatment of colon cancer. ..
  48. Antigenic determinants on HLA-B7 and-A2
    VICTOR ENGELHARD; Fiscal Year: 2006
    ..Collectively, these studies will continue to use mass spectrometry to offer insight into the display of peptides by MHC molecules of cancer cells, and the relevance of this display to control of tumors by the immune system. ..
  49. CALNEXIN AND CLASS I MHC FUNCTION
    Russell Salter; Fiscal Year: 2001
    ..Several assays have been established to determine whether calnexin mutants are functional. ..
  50. CYTOLYTIC T CELLS IN UVEAL MELANOMA
    June Kan Mitchell; Fiscal Year: 1993
    ..Furthermore, information regarding the melanoma-associated antigens recognized may be useful for designing immunotherapeutic protocols for this disease...
  51. VACCINATION FOR CMV IN AIDS PATIENTS UNDERGOING HAART
    Don Diamond; Fiscal Year: 2001
    ..It is composed of the HLA A*0201-restricted CTL epitope from pp65 covalently attached to a powerful synthetic T-helper epitope, and lipidated ..
  52. Structural Analysis , mutation and therapeutic use of TCRs from HIV-specific CTLs
    Harris Goldstein; Fiscal Year: 2009
    ....
  53. IMPROVED MATCHING TECHNIQUES IN RENAL TRANSPLANTATION
    FOLKERT BELZER; Fiscal Year: 1980
    ..New developments, both with respect to organ preservation and donor-recipient matching, will be added to the protocols as indicated during the grant...
  54. Polypeptide Vaccine In IL-2 Liposomes For Prostate Ca
    SANDRA REYNOLDS; Fiscal Year: 2006
    ..Successful completion of this work may provide a new treatment for prostate cancer that has minimal toxicity, that improves quality of life, and that has the ultimate potential to prevent this cancer. ..
  55. EXPRESSION & FUNCTION OF THREE NEW HLA CLASS I ANTIGENS
    Daniel Geraghty; Fiscal Year: 1993
    ..b) We will concentrate on the T cell reactivity of the soluble HLA-G protein by attempting to measure it's effect on normal T cell function in vitro...
  56. SOLUBLE FORMS OF HLA-A B AND CHRONIC REJECTION
    WILLIAM BURLINGHAM; Fiscal Year: 2001
    ....
  57. Vitiligo in Tyrosinase-specific TCR Transgenic Mice
    VICTOR ENGELHARD; Fiscal Year: 2005
    ..abstract_text> ..
  58. HLA-ALL IN THE CELLULAR IMMUNE RESPONSE TO HIV-1
    Marlene Bouvier; Fiscal Year: 2001
    ..Knowledge derived from these studies will therefore be useful in relation to HIV-1 infection and other infectious diseases prevalent in SEA where this allele is extremely common. ..
  59. STRUCTURE & EXPRESSION OF NON HLA-A, B, C CLASS I GENES
    Rakesh Srivastava; Fiscal Year: 1991
    ..Subtraction cDNA cloning strategy ins planned to identify the receptors if they do not belong th the Alpha-Beta or Gamma-Delta category...
  60. HLA classl complex expression in breast cancer immunity
    Keith Knutson; Fiscal Year: 2009
    ..HLA-A* 0201-HER2/neu peptide complex downregulation reduces breast cancer cell recognition and cytotoxicity by HLAA* 0201-HER2/neu peptide-specific CTL, (4) To examine whether HLA-A*0201-HER2/neu peptide complex downregulation in ..
  61. HLA-G AND EQUIVALENT AND FETO-MATERNAL INTERACTION
    Hidde Ploegh; Fiscal Year: 2003
    ....
  62. HLA TYPING USING OLIGONUCLEOTIDE ARRAYS.
    Jar How Lee; Fiscal Year: 1999
    ..Revenues will be derived from the sales of the system. ..
  63. H2-M3 AND T CELL DEVELOPMENT AND IMMUNITY
    Chyung Ru Wang; Fiscal Year: 2000
    ..The ability of M3 to bind mitochondrial self-peptides may also make this a useful model for studying the mechanism of infection-induced autoimmunity. ..
  64. Functional HLA-A*201-peptide and DR0401-peptide microarrays for Type 1 diabetes
    William Kwok; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  65. Multifactorial Genetic Disease Model:Schizophrenial/HLA
    Wendie Robbins; Fiscal Year: 2003
    ..The candidate lacks the training necessary for research at the gene or gene and gene/environment interaction level. Schizophrenia (as an example of a complex genetic disorder) will provide an excellent model for training. ..
  66. COLLABORATIVE CORNEAL TRANSPLANTATION STUDIES
    Gary Foulks; Fiscal Year: 1991
    ..A Central HLA Laboratory will oversee standardization among the laboratories. A Coordinating Center will serve as the central data collection, data analysis, and administrative center...