HLA-DRB4

Summary

Gene Symbol: HLA-DRB4
Description: major histocompatibility complex, class II, DR beta 4
Alias: DR4, DRB4, HLA-DR4B, major histocompatibility complex, class II, DR beta 4, HLA class II histocompatibility antigen, DR beta 4 chain, MHC class II antigen DRB4
Species: human

Top Publications

  1. ncbi Utility of posttransplantation panel-reactive antibody measurements for the prediction of rejection frequency and survival of heart transplant recipients
    J F George
    Department of Surgery, University of Alabama at Birmingham 35294 0007, USA
    J Heart Lung Transplant 14:856-64. 1995
  2. pmc In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes
    L Wen
    Section of Endocrinology, Department of Internal Medicine, the Yale University Shool of Medicine, New Haven, CT, USA
    J Exp Med 191:97-104. 2000
  3. ncbi Rebuilding human leukocyte antigen class II-restricted minor histocompatibility antigen specificity in recall antigen-specific T cells by adoptive T cell receptor transfer: implications for adoptive immunotherapy
    Robbert Spaapen
    Authors Affiliations Departments of Clinical Chemistry and Haematology, Immunology, and Haematology, University Medical Center Utrecht, The Netherlands
    Clin Cancer Res 13:4009-15. 2007
  4. doi Successful tapering of immunosuppression to low-dose monotherapy steroids after living-related human leukocyte antigen-identical renal transplantation
    Jacqueline van de Wetering
    Department of Internal Medicine and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 87:740-4. 2009
  5. doi Associations of human leukocyte antigen DRB with resistance or susceptibility to HIV-1 infection in the Pumwani Sex Worker Cohort
    Philip A Lacap
    National Microbiology Laboratory, Winnipeg, Canada
    AIDS 22:1029-38. 2008
  6. ncbi Differential effects of R5 and X4 human immunodeficiency virus type 1 infection on CD4+ cell proliferation and activation
    Christopher P Locher
    Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, CA 94143, USA
    J Gen Virol 86:1171-9. 2005
  7. pmc Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) study
    Suzanne K Cordovado
    Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F 24, Atlanta, GA 30341, USA
    Diabetes 57:518-22. 2008
  8. ncbi Human macrophages accumulate HIV-1 particles in MHC II compartments
    Graca Raposo
    Institut Curie, CNRS UMR 144, Paris, France
    Traffic 3:718-29. 2002
  9. ncbi Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort
    Shu Li
    Vaccine Laboratory, Nankai University, Tianjin, China
    J Acquir Immune Defic Syndr 44:121-31. 2007
  10. ncbi HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma
    M Tevfik Dorak
    Department of Epidemiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    J Med Virol 76:302-10. 2005

Research Grants

  1. IDENTIFICATION OF DOMINANT HUMAN ALLO EPITOPES
    Steven Takemoto; Fiscal Year: 2002
  2. Julie M Yabu; Fiscal Year: 2015
  3. Tibor T Glant; Fiscal Year: 2016
  4. DOUGLAS FREDERICK LEVINSON; Fiscal Year: 2015
  5. HLA-DQ Sequencing Studies in Narcolepsy/Hypocretin Deficiency
    Emmanuel J Mignot; Fiscal Year: 2012
  6. Functional and Structural Studies of CD74 Activation
    Elias Lolis; Fiscal Year: 2010
  7. Use of Allogenicity to Stimulate Effector Responses Against Multiple Myeloma
    Christina N Johnson; Fiscal Year: 2013
  8. Sophia S Wang; Fiscal Year: 2016
  9. Innate Immune Response Genetics and T cell Activation in Treated HIV Infection
    Peter W Hunt; Fiscal Year: 2010
  10. The Genetics of Age-related Hearing Loss
    Dina L Newman; Fiscal Year: 2010

Detail Information

Publications526 found, 100 shown here

  1. ncbi Utility of posttransplantation panel-reactive antibody measurements for the prediction of rejection frequency and survival of heart transplant recipients
    J F George
    Department of Surgery, University of Alabama at Birmingham 35294 0007, USA
    J Heart Lung Transplant 14:856-64. 1995
    ..A total of 465 panel-reactive antibodies determinations were made during the first year after transplantation...
  2. pmc In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes
    L Wen
    Section of Endocrinology, Department of Internal Medicine, the Yale University Shool of Medicine, New Haven, CT, USA
    J Exp Med 191:97-104. 2000
    ..B7-1 C57BL/6 mice. Our data provide direct in vivo evidence for the diabetogenic effect of this human MHC class II molecule and a unique "humanized" animal model of spontaneous diabetes...
  3. ncbi Rebuilding human leukocyte antigen class II-restricted minor histocompatibility antigen specificity in recall antigen-specific T cells by adoptive T cell receptor transfer: implications for adoptive immunotherapy
    Robbert Spaapen
    Authors Affiliations Departments of Clinical Chemistry and Haematology, Immunology, and Haematology, University Medical Center Utrecht, The Netherlands
    Clin Cancer Res 13:4009-15. 2007
    ....
  4. doi Successful tapering of immunosuppression to low-dose monotherapy steroids after living-related human leukocyte antigen-identical renal transplantation
    Jacqueline van de Wetering
    Department of Internal Medicine and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 87:740-4. 2009
    ..No data are available on the need for immunosuppression for these specific patients. We wondered whether their immunosuppressive load could be radically reduced...
  5. doi Associations of human leukocyte antigen DRB with resistance or susceptibility to HIV-1 infection in the Pumwani Sex Worker Cohort
    Philip A Lacap
    National Microbiology Laboratory, Winnipeg, Canada
    AIDS 22:1029-38. 2008
    ..DRB1 is the most polymorphic locus among class II genes and forms haplotypes with DRB3, DRB4 and DRB5...
  6. ncbi Differential effects of R5 and X4 human immunodeficiency virus type 1 infection on CD4+ cell proliferation and activation
    Christopher P Locher
    Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, CA 94143, USA
    J Gen Virol 86:1171-9. 2005
    ..02). Taken together, these results indicate that CD4+ cells infected with R5 virus isolates may have a selective advantage over X4 virus-infected CD4+ T cells for survival and, hence, virus spread...
  7. pmc Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) study
    Suzanne K Cordovado
    Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F 24, Atlanta, GA 30341, USA
    Diabetes 57:518-22. 2008
    ..The availability of phenotypic and genotypic data on GoKinD participants allowed a detailed analysis of the association of these genes with diabetic nephropathy...
  8. ncbi Human macrophages accumulate HIV-1 particles in MHC II compartments
    Graca Raposo
    Institut Curie, CNRS UMR 144, Paris, France
    Traffic 3:718-29. 2002
    ..Our observations also suggest direct fusion of the virus containing major histocompatibility complex class II compartment with the plasma membrane, leading to massive release of viral particles into the extracellular medium...
  9. ncbi Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort
    Shu Li
    Vaccine Laboratory, Nankai University, Tianjin, China
    J Acquir Immune Defic Syndr 44:121-31. 2007
    ..Several class II alleles were found at high frequency (>or=10%): HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DRB1*0701, HLA-DRB1*1501, HLA-DRB1*0401, HLA-DRB1*0901, HLA-DRB1*1201, HLA-DQB1*0601, HLA-DQB1*0301, ..
  10. ncbi HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma
    M Tevfik Dorak
    Department of Epidemiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    J Med Virol 76:302-10. 2005
    ..HLA-B, DRB1, DRB3, DRB4, DRB5, and DQB1 polymorphisms were examined by high-resolution DNA-based methods...
  11. ncbi Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
    L K Clayton
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, Massachusetts
    Nature 339:548-51. 1989
    ....
  12. ncbi Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC
    J F Rowell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 155:473-88. 1995
    ....
  13. ncbi Cross-reactive cytotoxic T lymphocytes induced by V3 loop synthetic peptides from different strains of human immunodeficiency virus type 1
    K S Casement
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Virology 211:261-7. 1995
    ....
  14. ncbi HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes
    K M Callahan
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 151:2928-42. 1993
    ..These results provide the first direct evidence that endogenously synthesized membrane proteins enter the class II-restricted Ag-processing pathway after expression on the cell surface in an intact form...
  15. ncbi Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA
    H Okamoto
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi, 467 8601, Japan
    Biochem Biophys Res Commun 279:494-9. 2000
    ..These reciprocal actions between Tat and CIITA not only explains the functional impairment of APC in HIV-1 infection but also rationalizes the suppression of HIV-1 virus load by induction of CIITA such as IFN-gamma...
  16. ncbi Fetal growth is increased by maternal type 1 diabetes and HLA DR4-related gene interactions
    M Hummel
    Institute of Diabetes Research and Academic Hospital Schwabing, Kolner Platz 1, 80804, Munchen, Germany
    Diabetologia 50:850-8. 2007
    ..The aim of this study was to determine whether HLA DR4 was associated with increased birthweight in a maternal diabetes environment and whether effects persisted during ..
  17. ncbi HLA-DR-restricted peptides identified in the Nef protein can induce HIV type 1-specific IL-2/IFN-gamma-secreting CD4+ and CD4+ /CD8+ T cells in humans after lipopeptide vaccination
    Hanne Gahery
    INSERM U567, 75014 Paris, France
    AIDS Res Hum Retroviruses 23:427-37. 2007
    ..To conclude, these 26 Nef HLA-DR-restricted peptides could be helpful to better evaluate CD4(+) deficiencies in HIV infection and, for new vaccine designs...
  18. ncbi HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets
    Maria Giovanna Quaranta
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    FASEB J 21:2323-34. 2007
    ..Our findings suggest that the Nef-induced dysregulation in the DC/NK cell crosstalk may represent a potential mechanism through which HIV escapes innate immune surveillance...
  19. pmc Productive human immunodeficiency virus type 1 assembly takes place at the plasma membrane
    Andres Finzi
    Laboratory of Human Retrovirology, Institut de recherches cliniques de Montreal IRCM, Univerisité de Montréal, Montreal, Quebec, Canada
    J Virol 81:7476-90. 2007
    ..These results point towards the PM as being the primary site of productive HIV-1 assembly in cells that also support Gag accumulation in intracellular compartments...
  20. doi HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway
    Ashutosh Chaudhry
    National Institute of Immunology, New Delhi, India
    J Immunol 183:2415-24. 2009
    ..Thus, Nef-mediated endocytosis of MHCII provides a novel perspective on the regulation of normal MHCII trafficking...
  21. doi Role of HIV-1 Nef protein for virus replication in vitro
    Abhay Jere
    Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Microbes Infect 12:65-70. 2010
    ..This review summarizes and organizes current knowledge of HIV-1 Nef with respect to this particularly virological activity for understanding the basis of its in vivo function...
  22. doi HLA-DR genotypes influence age at disease onset in children and juveniles with type 1 diabetes mellitus
    W L Awa
    Department of Epidemiology, Faculty of Medicine, Division of Endocrinology and Diabetes, Clinic for Internal Medicine I, University of Ulm, Ulm 89081, Germany
    Eur J Endocrinol 163:97-104. 2010
    ..Genotype associations with gender and ethnicity are also analyzed...
  23. ncbi Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help
    N Chirmule
    Department of Pediatrics, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030
    Cell Immunol 155:169-82. 1994
    ..Furthermore, these latter reactions occur subsequent to T-B cell contact-dependent interactions at the effector phase, which involve MHC class II molecules on B cells and CD4 molecules on T cells...
  24. ncbi NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type tumor-reactive CD4+ T cells
    Hassane M Zarour
    Department of Medicine and Melanoma Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 62:213-8. 2002
    ..They support the relevance of cancer vaccine trials with the NY-ESO-1 119-143 peptide in the large number of cancer patients with NY-ESO-1-expressing tumors...
  25. ncbi HIV-1 gag polyprotein rescues HLA-DR intracellular transport in a human CD4+ cell line
    Pablo Gluschankof
    Unite des Rickettsies, UMR 6020, IFR 48 Pathologies Transmissibles et Pathologies Infectieuses Tropicales, Faculte de Medecine, 27 Boulevarde Jean Moulin, 13385, Marseille Cedex 5, France
    Virology 300:160-9. 2002
    ..Moreover, in a specific cell type as H78-C10.0 this interaction can even reverse intracellular transport defects...
  26. ncbi Genetic association of type 1 diabetes in an Azerbaijanian population: the HLA-DQ, -DRB1*04, the insulin gene, and CTLA4
    Gunduz Ahmedov
    Azerbaijan Medical University, Str K Ragimov 11, Baku, Azerbaijan Republic
    Pediatr Diabetes 7:88-93. 2006
    ..Little is known on the genetic susceptibility to type 1 diabetes mellitus (T1DM) in the nations of the former Soviet part of south-west Asia...
  27. pmc Major histocompatibility complex class II molecules promote human immunodeficiency virus type 1 assembly and budding to late endosomal/multivesicular body compartments
    Andres Finzi
    Unité de Rétrovirologie Humaine, Institut de Recherches Cliniques de Montreal, Montreal, Canada
    J Virol 80:9789-97. 2006
    ....
  28. pmc Tat protein induces self-perpetuating permissivity for productive HIV-1 infection
    C J Li
    Division of Cell Growth and Regulation, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA cjli mbcrr harvard edu
    Proc Natl Acad Sci U S A 94:8116-20. 1997
    ..Accordingly, these primary T cells progressed from G0 to the late G1 phase of the cell cycle...
  29. ncbi Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses
    Emanuele Fanales-Belasio
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Immunol 168:197-206. 2002
    ..Thus, Tat can act as both Ag and adjuvant, capable of driving T cell-mediated immune responses...
  30. pmc MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation
    Aude de Gassart
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 105:3491-6. 2008
    ..MARCH I is, therefore, a major regulator of HLA-DR traffic, and its loss contributes to the acquisition of the potent immunostimulatory properties of mature human DCs...
  31. ncbi HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells
    Marc A Williams
    Division of Pediatric Infectious Diseases, University of California at San Diego, The School of Medicine, La Jolla 92093, USA
    J Hematother Stem Cell Res 11:829-47. 2002
    ..Consequently, HIV-1 gp120 may actively contribute to the immunopathogenesis of AIDS...
  32. pmc Human immunodeficiency virus type 1 Vpu protein interacts with CD74 and modulates major histocompatibility complex class II presentation
    Amjad Hussain
    Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Virol 82:893-902. 2008
    ..Thus, the Vpu protein also contributes to viral persistence by attenuating immune responses during HIV infection. This report further exemplifies the rich diversity and redundancy shown by HIV in immune evasion...
  33. pmc HLA haplotypes, polysomnography, and pedigrees in a case series of patients with narcolepsy
    R Hayduk
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California, USA
    Sleep 20:850-7. 1997
    ..One family contains a pair of DNA-confirmed, monozygotic twins with narcolepsy who are discordant for cataplexy and have the HLA DR14(Dw9)/DQB1*0503 and DR4(Dw4)/DQB1*0302 haplotypes.
  34. ncbi Modulation of human leukocyte antigen-DR on monocytes and CD16 on granulocytes in patients with septic shock using hemoperfusion with polymyxin B-immobilized fiber
    Satoshi Ono
    Department of Surgery I, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama 359 8513, Japan
    Am J Surg 188:150-6. 2004
    ....
  35. doi Influence of iodide excess and interferon-gamma on human primary thyroid cell proliferation, thyroglobulin secretion, and intracellular adhesion molecule-1 and human leukocyte antigen-DR expression
    Irena Kostic
    Institute of Pathophysiology, School of Medicine, University of Kragujevac, Kragujevac, Serbia
    Thyroid 19:283-91. 2009
    ....
  36. ncbi Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602
    E Mignot
    Stanford University, Department of Psychiatry and Behavioral Sciences, CA 94305-5485, USA
    Sleep 22:347-52. 1999
    ..These results support the hypothesis that polymorphisms at the level of HLA DQ modulates sleep tendencies in humans...
  37. ncbi Human leukocyte antigen-DR expression on peripheral blood monocytes and the risk of pneumonia in pediatric lung transplant recipients
    J A Hoffman
    Department of Pediatrics, Division of Infectious Diseases, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA
    Transpl Infect Dis 6:147-55. 2004
    ..In addition, interleukin (IL)-10 has been shown to be a negative regulator of HLA-DR expression. This study investigates whether HLA-DR expression and serum IL-10 levels correlate with the development of pneumonia after pediatric LT...
  38. ncbi HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China
    E Trachtenberg
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Tissue Antigens 70:455-63. 2007
    ..The DR4 lineage also shows extensive expansion in this population, with seven subtypes, representing one quarter of the ..
  39. ncbi [Clinical trial to verify the value of the CD14(+) monocyte human leukocyte antigen DR as a marker in evaluating immunosuppression in patients with severe sepsis]
    Hong yuan Lin
    Trauma Center, 304th Hospital of People s Liberation Army, Beijing 100037, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:135-8. 2003
    ....
  40. ncbi [Gene and haplotype frequencies for the loci HLA-A, B and DRB1 in 11755 north Chinese Han bone marrow registry donors]
    Qiang Ju Wu
    Blood Center of Shanxi Province, Xi an 710061, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:357-63. 2007
    ..The study will be helpful to find matched donors for patients and establish the important foundation for further studying of transplantation immunity, HLA-related diseases and population genetics of this area...
  41. ncbi No evidence of autoimmunity in 6-year-old children immunized at birth with recombinant hepatitis B vaccine
    Cesare Belloni
    Division of Neonatal Intensive Care, IRCCS Policlinico San Matteo, Pavia, Italy
    Pediatrics 110:e4. 2002
    ....
  42. ncbi Human leukocyte antigen-DR expression on peripheral monocytes as a predictive marker of sepsis during acute pancreatitis
    Akihiko Satoh
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Pancreas 25:245-50. 2002
    ..However, objective parameters for the risk of sepsis in acute pancreatitis have not been established...
  43. ncbi Mononuclear histocompatibility leukocyte antigen-DR expression in the early phase of acute pancreatitis
    Wen kui Yu
    Department of General Surgery, School of Medince, Nanjing University, Nanjing, PR China
    Pancreatology 4:233-43. 2004
    ..We investigated the time course of HLA-DR expression in the early phase of AP and the relationship to markers of inflammation, severity of the disease, organ function, septic complications and outcome during AP...
  44. ncbi Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype
    T Sakou
    Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, Japan
    Spine (Phila Pa 1976) 16:1249-52. 1991
    ....
  45. ncbi Loss of CD38 correlates with simultaneous up-regulation of human leukocyte antigen-DR in benign prostatic glands, but not in fetal or androgen-ablated glands, and is strongly related to gland atrophy
    G Kramer
    Department of Urology, University of Vienna, Austria
    BJU Int 91:409-16. 2003
    ..To determine whether CD38 loss in benign and malignant prostatic disease is related to human leukocyte antigen (HLA)-DR up-regulation, by assessing the histopathology of the prostate and the effect of androgen deprivation...
  46. ncbi Unravelling an HLA-DR association in childhood acute lymphoblastic leukemia
    M T Dorak
    Department of Haematology, University of Wales College of Medicine, Cardiff, Wales, UK
    Blood 94:694-700. 1999
    ..0005, odds ratio = 2.9). When the other expressed HLA-DRB loci were examined, homozygosity for HLA-DRB4*01, encoding the HLA-DR53 specificity, was increased in patients (21.1% v 8.3%; odds ratio = 2.9, P =.0005)...
  47. ncbi A controlled study of serum anti-locus ceruleus antibodies in REM sleep behavior disorder
    C H Schenck
    Minnesota Regional Sleep Disorders Center, Hennepin County Medical Center, Minneapolis 55415, USA
    Sleep 20:349-51. 1997
    ..Therefore, it is unlikely that human RBD is associated with anti-LC antibodies. However, an autoimmune process in RBD has not been excluded by this study...
  48. doi Epithelial human leukocyte antigen-DR expression predicts reduced recurrence rates and prolonged survival in rectal cancer patients
    Elza C de Bruin
    Department of Clinical Oncology and Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Clin Cancer Res 14:1073-9. 2008
    ..In this study, we investigated whether epithelial human leukocyte antigen-DR (HLA-DR) expression allowed discrimination between high and low tumor recurrence rates, and analyzed the mechanism behind its expression...
  49. ncbi Up-regulation of interleukin-10 mRNA expression in peripheral leukocytes predicts poor outcome and diminished human leukocyte antigen-DR expression on monocytes in septic patients
    Ryuzo Abe
    Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Surg Res 147:1-8. 2008
    ..None of the parameters can predict the deterioration of sepsis early enough. A new predictor allowing earlier detection of changes in septic patients' condition is indispensable...
  50. ncbi [Clinical significance of changes in quantitative expression of human leukocyte antigen DR in severely burned patients]
    Ning Dong
    Burns Institute, First Hospital Affiliated to the China People s Liberation Army General Hospital, Beijing 100037, China
    Zhonghua Wai Ke Za Zhi 45:766-9. 2007
    ..To investigate the clinical significance of kinetic changes in quantitative expression of human leukocyte antigen DR (HLA-DR) in severely burned patients...
  51. ncbi [Monocyte human leukocyte antigen-DR expression in elderly patients with sepsis]
    Jun Wu
    Department of Gerontology, Guangzhou General Hospital of Guangzhou Command, Guangzhou, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:1657-9. 2008
    ..To investigate the changes of human leukocyte antigen DR (HLA-DR) expression in the monocytes of elderly patients with sepsis...
  52. doi Distribution of human leukocyte antigen alleles and haplotypes in Oroqen and Ewenki nationality minority in Inner Mongolia Autonomous Region of China
    H B Zhang
    Key Laboratory of Ministry of Health for Forensic Sciences, School of Medicine, Xi an Jiaotong University
    Int J Immunogenet 37:337-44. 2010
    ..The distribution of HLA A,-B, DRB1, alleles haplotypes frequencies and phylogenetic tree indicated that the Oroqen and Ewenki population groups belongs to northern group of China, together as a group cluster...
  53. doi Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection
    Rae Anne Hardie
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    AIDS 22:807-16. 2008
    ..To determine the association of DQ antigens with resistance and susceptibility to HIV-1...
  54. ncbi Disseminated BCG infection following bone marrow transplantation for X-linked severe combined immunodeficiency
    R H McKenzie
    Departments of Dermatology, Groote Schuur Hospital, Cape Town, South Africa
    Pediatr Dermatol 17:208-12. 2000
    ..At follow-up 1 year post-BMT he showed good general physical improvement. All abscesses had healed with scarring, and no further skin lesions had occurred...
  55. ncbi [Polymorphism of human HLA-DRB1 leukocyte antigen alleles and its association to juvenile rheumatoid arthritis in a sample of Colombian mestizo children]
    Gloria Garavito
    Universidad Autonoma de Barcelona, Barcelona, Espana
    Biomedica 23:254-62. 2003
    ..005, OR = 21.33, EF = 0.95) was most frequent. These results suggested that the MHC genes of mestizo children influence not only the clinical expression of the disease, but also the susceptibility to its development...
  56. ncbi Celiac disease: risk assessment, diagnosis, and monitoring
    Mala Setty
    Section of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
    Mol Diagn Ther 12:289-98. 2008
    ....
  57. pmc Primary sclerosing cholangitis in genetically diverse populations listed for liver transplantation: unique clinical and human leukocyte antigen associations
    Christopher L Bowlus
    Division of Gastroenterology and Hepatology, University of California Davis, Davis, CA 95817, USA
    Liver Transpl 16:1324-30. 2010
    ..African Americans with PSC versus alcoholic liver disease were detected for HLA-B8, HLA-DR13, and protective HLA-DR4. However, HLA-DR3, which is in linkage disequilibrium with HLA-B8, showed associations only in European Americans ..
  58. ncbi [Study on the gestational diabetes mellitus and histocompatibility human leukocyte antigen DRB allele polymorphism]
    Dianrong Song
    Department of Obstetric and Gynecology, Second Hospital of Tianjin Medical University, Tianjin 300211, China
    Zhonghua Fu Chan Ke Za Zhi 37:284-6. 2002
    ....
  59. ncbi Symptomatic narcolepsy, cataplexy and hypersomnia, and their implications in the hypothalamic hypocretin/orexin system
    Seiji Nishino
    Center for Narcolepsy, Stanford University, Palo Alto, CA 94304, USA
    Sleep Med Rev 9:269-310. 2005
    ..It appears that further studies of the involvement of the hypocretin system in symptomatic narcolepsy and EDS are helpful to understand the pathophysiological mechanisms for the occurrence of EDS and cataplexy...
  60. ncbi Association of bovine leukocyte antigen (BoLA) DRB3.2 with immune response, mastitis, and production and type traits in Canadian Holsteins
    R Rupp
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Dairy Sci 90:1029-38. 2007
    ..This does not imply that genetic selection for mastitis resistance should be based on BoLA alleles, but that information on a variety of genes may aid in identification and selection for improved health...
  61. doi Detection of bovine leukocyte antigen DRB3 alleles as candidate markers for clinical mastitis resistance in Holstein x Zebu
    M Duangjinda
    Department of Animal Science, Faculty of Agriculture, Khon Kaen University, Thailand
    J Anim Sci 87:469-76. 2009
    ..This study revealed that allele DRB3*10 had the greatest effect on increasing milk yield with moderate resistance to clinical mastitis, which could be used as a potential marker for selection in dairy genetic evaluation...
  62. pmc Specific human leukocyte antigen class I and II alleles associated with hepatitis C virus viremia
    Mark H Kuniholm
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 51:1514-22. 2010
    ..We additionally studied the relation of HLA alleles with HCV infection (serostatus) in women at high risk of HCV from injection drug use (N = 838), but no significant relationships were observed...
  63. ncbi Low prevalence of selective human leukocyte antigen (HLA)-A and HLA-B epitope losses in early-passage tumor cell lines
    P Giacomini
    Laboratory of Immunology Regina Elena Institute, Centro della Ricerca Sperimentale, Rome, Italy
    Cancer Res 59:2657-67. 1999
    ..This alternative model of tumor-host interaction better fits the available models of tumor cell recognition by CTLs and natural killer cells bearing activatory and inhibitory receptors for HLA-A, HLA-B, HLA-C molecules...
  64. ncbi The role of human leukocyte antigen genes in the formation of abdominal aortic aneurysms
    Stephen A Badger
    Vascular and Endovascular Surgery Centre, Belfast City Hospital, Belfast, United Kingdom
    J Vasc Surg 45:475-80. 2007
    ..This study was conducted to determine if a difference exists in human leukocyte antigen (HLA) allele distribution between patients with AAA and population controls, and between patients with small and large AAA...
  65. ncbi Racial differences in HLA antigen frequency and hypertensive renal failure
    B I Freedman
    Department of Medicine/Nephrology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103
    Am J Hypertens 4:393-8. 1991
    ..White cases compared to white controls had lower HLA-A1 and B8 frequencies (21.2% v 30.6%, P = .0005 and 13.7% v 22.3%, P = .001, respectively) and a greater HLA-B35 frequency (20.7% v 14.2%, P = .02).(ABSTRACT TRUNCATED AT 250 WORDS)..
  66. ncbi Does human leukocyte antigen matching influence the outcome of lung transplantation? An analysis of 3,549 lung transplantations
    M A Quantz
    London Health Sciences Centre and The University of Western Ontario, London, Canada
    J Heart Lung Transplant 19:473-9. 2000
    ....
  67. ncbi DR2-positive monozygotic twins discordant for narcolepsy
    T Pollmacher
    Max Planck Institute for Psychiatry, Munich, F R G
    Sleep 13:336-43. 1990
    ..Our results strongly favor a multifactorial pathogenetic model for narcolepsy...
  68. ncbi Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Infect Dis 193:655-63. 2006
    ..002). Better characterization of such HLA profiles could inform and improve the design of novel epitope-rich vaccines and help to predict protective immune responses at the individual and population level...
  69. ncbi The presence of thyrogastric antibodies in first degree relatives of type 1 diabetic patients is associated with age and proband antibody status
    C E De Block
    Department of Endocrinology Diabetology, University Hospital Antwerp, B 2650 Edegem, Belgium
    J Clin Endocrinol Metab 86:4358-63. 2001
    ..The presence of these antibodies in relatives is associated with age and proband antibody status, but not with beta-cell antibodies or human leukocyte antigen-DQ type...
  70. ncbi [Narcolepsy in a prepubertal boy]
    H Tsukamoto
    Department of Pediatrics, Nagoya City University Medical School, Nagoya
    No To Hattatsu 33:523-7. 2001
    ..Therefore, they need early diagnosis and treatment. Assistance should be provided to protect them from being labeled as lazy by their parents and school teachers...
  71. ncbi Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetes
    Maria J Redondo
    Department of Endocrinology, University Clinic of Navarra, 31008 Pamplona, Spain
    J Clin Endocrinol Metab 91:1705-13. 2006
    ..Human leukocyte antigen (HLA) DQ haplotypes have the strongest genetic association with type 1 diabetes (T1DM) risk...
  72. ncbi A single minor histocompatibility antigen encoded by UGT2B17 and presented by human leukocyte antigen-A*2902 and -B*4403
    Seitaro Terakura
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Transplantation 83:1242-8. 2007
    ....
  73. ncbi Possible role of natural killer cells in negative selection of mutant lymphocytes that fail to express the human leukocyte antigen-A2 allele
    Y Kusunoki
    Department of Radiobiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ward, Hiroshima 732 0815, Japan
    Mutat Res 476:123-32. 2001
    ....
  74. ncbi Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors
    Angelica Facoetti
    Department of Animal Biology, University of Pavia and Center of Study for Histochemistry, Consiglio Nazionale delle Ricerche, Italy
    Clin Cancer Res 11:8304-11. 2005
    ..This information may contribute to our understanding of the immune escape mechanisms used by malignant brain tumors because HLA antigens mediate interactions of tumor cells with the host's immune system...
  75. doi Formation of anti-platelet factor 4/heparin antibodies after cardiac surgery: influence of perioperative platelet activation, the inflammatory response, and histocompatibility leukocyte antigen status
    Domenico Paparella
    Division of Cardiac Surgery, Department of Emergency and Organ Transplant, University of Bari, Bari, Italy
    J Thorac Cardiovasc Surg 136:1456-63. 2008
    ..We also examined the relationship between anti-platelet factor 4/heparin seroconversion and the histocompatibility leukocyte antigen system...
  76. pmc Ocular pathology in multiple sclerosis: retinal atrophy and inflammation irrespective of disease duration
    Ari J Green
    Multiple Sclerosis Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    Brain 133:1591-601. 2010
    ..Deciphering the relationships between the different types of retinal pathology may aid us in understanding the factors that drive both inflammation and tissue atrophy in multiple sclerosis...
  77. ncbi Familial aspects of narcolepsy-cataplexy in the Czech Republic
    S Nevsimalova
    Department of Neurology 1st Medical Faculty, Charles University, Prague, Czech Republic
    Sleep 20:1021-6. 1997
    ....
  78. pmc Autoimmune type 1 diabetes genetic susceptibility encoded by human leukocyte antigen DRB1 and DQB1 genes in Tunisia
    Mouna Stayoussef
    Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia
    Clin Vaccine Immunol 16:1146-50. 2009
    ....
  79. ncbi Two distinct MICA gene markers discriminate major autoimmune diabetes types
    G Gambelunghe
    Department of Internal Medicine, University of Perugia, 06126 Perugia, Italy
    J Clin Endocrinol Metab 86:3754-60. 2001
    ..1, respectively...
  80. ncbi Ambiguities of human leukocyte antigen-B resolved by sequence-based typing of exons 1, 4, and 5
    W T N Swelsen
    Tissue Typing Laboratory, University Hospital Maastricht, The Netherlands
    Tissue Antigens 63:248-54. 2004
    ..The described SBT protocol for sequencing exons 1, 4, and 5 is a valuable tool for resolving ambiguities of HLA-B alleles with differences in these exons, as well as for studying the polymorphism of HLA-B outside exons 2 and 3...
  81. ncbi [Study on the relationship between chronic glomerulonephritis and human leukocyte antigen in Shandong province]
    Jing Jie Zhao
    Laboratory of Clinical Molecular Biology, Second Hospital of Shandong University, Jinan, China
    Zhonghua Liu Xing Bing Xue Za Zhi 28:1030-5. 2007
    ....
  82. pmc Human leukocyte antigen (HLA)-B, DRB1, and DQB1 allotypes associated with disease and protection of trachoma endemic villagers
    Muneer Abbas
    National Human Genome Center, Howard University, Washington, DC, USA
    Invest Ophthalmol Vis Sci 50:1734-8. 2009
    ....
  83. doi Comparative case control study of clinical features and human leukocyte antigen susceptibility between familial and nonfamilial vitiligo
    Rachita Misri
    Department of Dermatology, Seth G S Medical College and KEM Hospital, Parel, Mumbai 400 012, India
    Indian J Dermatol Venereol Leprol 75:583-7. 2009
    ..Various studies worldwide suggest that human leukocyte antigen (HLA) region may be involved in the genetic susceptibility of vitiligo but little information is available from India...
  84. doi Human monoclonal antibody reactivity with human leukocyte antigen class I epitopes defined by pairs of mismatched eplets and self-eplets
    Marilyn Marrari
    Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 90:1468-72. 2010
    ..This study addressed the question how mismatched HLA antigens induce specific antibodies in context with eplet differences with the antibody producer...
  85. ncbi Narcolepsy in children
    M J Challamel
    , Hopital Lyon-Sud, Pierre-Benite, France
    Sleep 17:S17-20. 1994
    ..An association with a Niemann-Pick disease type C was found in 12 out of the 20 symptomatic cases, this association merits further study...
  86. ncbi Frequency of human leukocyte antigen-A 24 alleles in patients with melanoma determined by human leukocyte antigen-A sequence-based typing
    M P Bettinotti
    Department of Transfusion Medicine, Clinical Center, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Immunother 23:282-7. 2000
    ..Finally, two new alleles, HLA-A*2422 and HLA-A*24 null, were identified. These results suggest that vaccination with HLA-A*2402-associated epitopes has the potential for broad use in this patient population...
  87. ncbi Polymorphism of human leukocyte antigen-E gene in the Japanese population with or without recurrent abortion
    T Kanai
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
    Am J Reprod Immunol 45:168-73. 2001
    ..The aim of this study was to investigate the gene frequencies and shared alleles of human leukocyte antigen (HLA)-E gene in Japanese couples with or without recurrent abortion...
  88. ncbi The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors
    Yasuo Morishima
    Department of Hematology and Chemotherapy, the Division of Epidemiology and Prevention, Aichi Cancer Center, Japan
    Blood 99:4200-6. 2002
    ..Thus, the role of the HLA class I allele in unrelated bone marrow transplantation was elucidated. Notably, HLA-C alleles had a different mode from HLA-A or -B alleles for acute GVHD and survival...
  89. pmc Immune response of mice transgenic for human histocompatibility leukocyte Antigen-DR to human thyrotropin receptor-extracellular domain
    Hidefumi Inaba
    Division of Endocrinology, Department of Medicine, Brown University, Providence, Rhode Island, USA
    Thyroid 19:1271-80. 2009
    ..Hyperthyroidism of Graves' disease is caused by auto-antibodies to human thyrotropin receptor (hTSH-R). To elucidate important T-cell epitopes in TSH-R, we studied three models of immunity to TSH-R in mice...
  90. ncbi [Association of chinese medicine constitution and human leukocyte antigen-DQA1 gene polymorphism with outcomes of hepatitis B virus infection]
    Yun hao Xun
    The Sixth People s Hospital of Hangzhou
    Zhongguo Zhong Xi Yi Jie He Za Zhi 30:141-5. 2010
    ....
  91. doi Specific "intra-allele" and "intra-broad antigen" human leukocyte antigen alloantibodies in kidney graft transplantation
    Manuel Muro
    Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Murcia, Spain
    Hum Immunol 71:857-60. 2010
    ..Post-transplantation with Luminex, we detected these alloantibodies, but as they were not IA and IBA DSA, they did not cause allograft injury...
  92. ncbi Human leukocyte antigen haplotypes and HFE mutations in Spanish hereditary hemochromatosis and sporadic porphyria cutanea tarda
    Mario Gonzalez-Hevilla
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    J Gastroenterol Hepatol 20:456-62. 2005
    ..However, sporadic porphyria cutanea tarda (s-PCT) has also been linked to these HFE mutations. In the present work, we have studied HFE mutations and HLA genes to test these hypotheses...
  93. doi Gluten intake interferes with the humoral immune response to recombinant hepatitis B vaccine in patients with celiac disease
    Eva Nemes
    Department of Pediatrics, Medical and Health Science Center, University of Debrecen, Nagyerdei krt 98, H 4032 Debrecen, Hungary
    Pediatrics 121:e1570-6. 2008
    ..We evaluated vaccine response in relation to disease activity and whether previous treatment with a gluten-free diet influences the achievement of protective antibody titers...
  94. ncbi Epidemiology of narcolepsy
    C Hublin
    Department of Neurology, University of Helsinki, Finland
    Sleep 17:S7-12. 1994
    ..In three subjects the narcolepsy diagnosis was verified (all dizygotic, nonfamilial and human leukocyte antigen DR2/DQB-0602 positive), giving a prevalence of 0.026% in the adult Finnish (Caucasian) population...
  95. ncbi Twin studies in narcolepsy
    M Partinen
    Department of Neurology, Finnish Twin Cohort, University of Helsinki, Finland
    Sleep 17:S13-6. 1994
    ..Not a single case suggestive of narcolepsy was found. Narcolepsy in monozygotic twins is very rare. These facts support the hypothesis of a multifactorial etiology with a strong influence of nongenetic environmental factors...
  96. ncbi CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory
    A Cossarizza
    Dipartimento di Scienze Biomediche, University of Modena, Italy
    Mech Ageing Dev 86:173-95. 1996
    ..Moreover, the data on centenarians suggest that they may represent a very selected population where a slowing of immunosenescence occurs...
  97. ncbi Differential surface expression of HLA-DRB1 and HLA-DRB4 among peripheral blood cells of DR4 positive individuals
    G Czerwony
    Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    Hum Immunol 60:1-9. 1999
    ..Differential regulation of DR4 and DRB4 was shown for peripheral blood monocytes...
  98. pmc Linkage of inflammatory bowel disease to human chromosome 6p
    J Hampe
    Medical Department, Christian Albrechts University Kiel, D 24105 Kiel, Germany
    Am J Hum Genet 65:1647-55. 1999
    ..In summary, we provide firm linkage evidence for an IBD-susceptibility locus on chromosome 6p and demonstrate that TNFA and LTA are unlikely to be susceptibility loci for IBD...
  99. ncbi Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immune-privileged sites
    S A Riemersma
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 96:3569-77. 2000
    ..In conclusion, a structural loss of HLA class I and II expression might help the B-cell lymphoma cells to escape from immune attack...
  100. ncbi The correlation of MHC haplotype and development of Behçet's disease-like symptoms induced by herpes simplex virus in several inbred mouse strains
    S Sohn
    Laboratory of Cell Biology, Ajou University Institute for Medical Sciences, Suwon, 442 749, South Korea
    J Dermatol Sci 26:173-81. 2001
    ..So, we conclude that MHC is not directly correlated with development of Behçet's disease-like symptoms in the animal model of herpes simplex virus induced Behçet's disease-like symptoms...
  101. ncbi Additive effect of the HLA-DR15 haplotype on susceptibility to multiple sclerosis
    H B Rasmussen
    Department of Life Sciences and Chemistry, Roskilde University, 1 Universitetsvej, DK 4000 Roskilde, Denmark
    Mult Scler 7:91-3. 2001
    ..Possible implications of our finding to future studies of the genetic background of MS is discussed...

Research Grants72

  1. IDENTIFICATION OF DOMINANT HUMAN ALLO EPITOPES
    Steven Takemoto; Fiscal Year: 2002
    ..Significance of this research applies to all fields of transplantation where MHC matching has an influence on graft outcome. ..
  2. Julie M Yabu; Fiscal Year: 2015
    ..Yabu's training. The planned research will form the basis for prospective studies using anti-B-cell therapies in sensitized kidney transplant recipients to be proposed in an R01 application before the end of the K23 award period. ..
  3. Tibor T Glant; Fiscal Year: 2016
    ....
  4. DOUGLAS FREDERICK LEVINSON; Fiscal Year: 2015
    ..The proposed analyses will allow us to dissect HLA associations with SCZ and will make major contributions to the understanding of HLA sequence variation. ..
  5. HLA-DQ Sequencing Studies in Narcolepsy/Hypocretin Deficiency
    Emmanuel J Mignot; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE (provided by applicant): Narcolepsy affects 1/2000 Americans and is a common neurological disorder. The proposed study may lead to new therapeutic avenues for the disorder. ..
  6. Functional and Structural Studies of CD74 Activation
    Elias Lolis; Fiscal Year: 2010
    ....
  7. Use of Allogenicity to Stimulate Effector Responses Against Multiple Myeloma
    Christina N Johnson; Fiscal Year: 2013
    ..Ultimately, this project seeks to contribute to the knowledge base currently being used to develop immunotherapies for diseases such as MM, specifically in populations which demonstrate well-documented health disparities. ..
  8. Sophia S Wang; Fiscal Year: 2016
    ..Public health relevance: successful completion of this study will contribute to the understanding of host genetic variation and tumor markers in NHL survival. ..
  9. Innate Immune Response Genetics and T cell Activation in Treated HIV Infection
    Peter W Hunt; Fiscal Year: 2010
    ..This research project will help identify inflammatory pathways that prevent immune system recovery in these patients, eventually leading to targeted interventions to improve immune system recovery. ..
  10. The Genetics of Age-related Hearing Loss
    Dina L Newman; Fiscal Year: 2010
    ..She will attend regular seminars, journal clubs, strategic sessions and annual international meetings on the topics of hearing and aging and will take courses in audition, statistical genetics and the responsible conduct of research. ..
  11. Eric Sundberg; Fiscal Year: 2014
    ....
  12. STRUCTURAL STUDY OF HLA-DQ2 AND AN ASSOCIATED COMPLEX
    Irimpan I Mathews; Fiscal Year: 2011
    ..apos;Preferential'presentation of gluten peptides by the DQ2.5 and DQ8 molecules thus seems to explain the association of HLA with celiac disease. ..
  13. PETER R PARHAM; Fiscal Year: 2016
    ..In this project we will precisely define HLA and KIR genetic variation within the human population. This information will enable the identification of disease-causing genes and their mechanism of action. ..
  14. Molecular epidemiology of cervical adenocarcinoma
    Hans Olov Adami; Fiscal Year: 2007
    ..The likelihood ratio test will be used to discriminate between nested models. Statistical power calculations produced for the specific aims show that our study is adequately sized. ..
  15. IDENTIFICATION OF HLA MRNA REGULATORY ELEMENTS
    JANE MCCUTCHEON; Fiscal Year: 2000
    ..These studies will increase our understanding of immune regulation. ..
  16. Functional Analysis of PAAN-AG5, the Baboon Counterpart of HLA-G5
    Daudi K Langat; Fiscal Year: 2010
    ..This proposal is aimed at assessing the feasibility of using the olive baboon as a model for HLA-G in vivo experiments. ..
  17. Elizabeth J Shpall; Fiscal Year: 2014
    ....
  18. Genome-wide Identification of Minor Histocompatibility Antigens
    Shoudan Liang; Fiscal Year: 2012
    ..We also expect our research to discover more candidates for leukemia vaccines. Because vaccination has few side effects, we can test the effectiveness of potential vaccines by administering them alongside existing therapies. ..
  19. David M Lewinsohn; Fiscal Year: 2016
    ..Confirmation of these results will be performed with Dr Karen Dobos (Colorado State University) and Bill Bishai (Johns Hopkins) using available mutants from a mariner transposon library. ..
  20. Retinal Iron Homeostasis in Health and Disease
    Vadivel Ganapathy; Fiscal Year: 2013
    ....
  21. Curry L Koening; Fiscal Year: 2016
    ..Finally, this study could revolutionize the treatment for GCA leading to the use of antibiotics as a potential cure for the disease. ..
  22. Eric B Larson; Fiscal Year: 2014
    ..Methods to use these results in clinical care will be guided by focus groups of patients and caregivers in the patient-centered Group Health system. ..
  23. Carole Ober; Fiscal Year: 2016
    ..abstract_text> ..
  24. CD20-targeted IL-15 immunotherapeutic for B-cell malignancies
    Hing C Wong; Fiscal Year: 2012
    ....
  25. Novel Immunotherapeutic Approaches and Tools Utilizing Allogeneic T Cells
    HEATHER JILL SYMONS; Fiscal Year: 2013
    ..This proposal is the foundation for future novel and widely applicable immunotherapies. ..
  26. David L Thomas; Fiscal Year: 2016
    ..There is a special focus on genes that appear to affect HIV and other chronic viral infections. ..
  27. Immune Response Gene Polymorphisms and AMD: Examining HLA-KIR Epistasis
    Gregory J Tranah; Fiscal Year: 2013
    ....
  28. Hematopoietic Cell Therapy for Young Adults with Severe Sickle Cell Disease
    Mark C Walters; Fiscal Year: 2013
    ..If successfully planned and initiated, the proposed comparative clinical trial would be the first to compare HCT and supportive care for SCD, and could broaden the therapeutic opportunities for adults with severe SCD. ..
  29. Elizabeth J Shpall; Fiscal Year: 2016
    ....
  30. KRISTIN PAGE-CHARTRAND; Fiscal Year: 2015
    ..If results from Aim 2 are favorable, further exploration into the impact of adding ALDHbr content to the CBA in these transplants is planned. ..
  31. Neutralization of ceramide as a novel approach to specifically inhibit acute GvHD
    Jimmy Rotolo; Fiscal Year: 2013
    ..In the current application, we propose to generate a high-affinity neutralizing anti-ceramide IgG for advancement into preclinical development. ..
  32. THE ROLE OF CTL ESCAPE MUTATIONS IN ATTENUATING HIV-1 SUBTYPE C INFECTION
    Carolyn Williamson; Fiscal Year: 2011
    ..This project was previously funded through CIPRA (U19 A151794-01). . ..
  33. Prevalence and immunogenicity of HNA-3a and -3b antibodies and antigens
    RICHARD HERBERT ASTER; Fiscal Year: 2012
    ..abstract_text> ..
  34. Phase I Study of ALT-801 in Metastatic Melanoma/Kidney Cancer Patients
    Mayer Fishman; Fiscal Year: 2009
    ....
  35. HCV resolution correlates with patterned KIR expressions on lymphocytes.
    James C Ryan; Fiscal Year: 2013
    ..These studies also will help to identify KIR as attractive drug targets for pharmacologic antiviral therapies. ..
  36. Joseph Holoshitz; Fiscal Year: 2016
    ....
  37. Pharmacogenetics of sulfamethoxazole in HIV/AIDS patients
    Danxin Wang; Fiscal Year: 2009
    ....
  38. The human placenta as a novel source of hematopoietic stem cells
    Alicia Barcena; Fiscal Year: 2009
    ....
  39. MECHANISMS OF AUTOIMMUNE ARTHRITIS
    EDWARD ROSLONIEC; Fiscal Year: 2001
    ..chimeric MHC class II molecules in which the peptide binding domain of the beta subunit is derived from DRB1 or DRB4, while the remainder of the beta subunit is of murine origin...
  40. Recombinant T Cell Receptor Ligands for Treatmentof Uveitis
    Grazyna Adamus; Fiscal Year: 2010
    ..Overall goal of this project is to develop new human DR3-derived RTLs and determine their efficacy and dosage requirements for the therapeutic treatment of patients with autoimmune uveitis. ..
  41. Genetic Determinants of Ankylosing Spondylitis Severity
    Michael Weisman; Fiscal Year: 2005
    ..abstract_text> ..
  42. IRRITANTS EFFECTS ON EPIDERMAL ANTIGEN PRESENTATION
    Anthony Gaspari; Fiscal Year: 2002
    ....
  43. Identification of Minor Histocompatibility Antigens
    David Miklos; Fiscal Year: 2006
    ..Dr. Miklos' research will be performed in the laboratory of Dr. Jerome Ritz, a leader in the field of immunology and allogeneic HSC transplantation at the Dana-Farber Cancer Institute...
  44. MODELS IN POPULATION GENETICS
    Glenys Thomson; Fiscal Year: 2000
    ..A framework for genetic counselling of HLA associated, and other complex diseases, will be developed. The results of our studies are generally applicable to the mapping and characterization of complex human genetic traits. ..
  45. NOD T CELL RECEPTORS FOR SPECIFIC ISLET AUTOANTIGENS
    Eric Simone; Fiscal Year: 2000
    ..3a TCR peptides selected from the polymorphic CDR regions or V(alpha)13.3 DNA constructs, in an attempt to eliminate or immunomodulate endogenous V(alpha)13.3a containing T cells that are potentially autoreactive. ..
  46. Optimizing Nonmyeloablative Stem Cell Transplantation
    Marco Mielcarek; Fiscal Year: 2007
    ..abstract_text> ..
  47. Non Myeloablative Histoincompatible Stem Cell Transplant
    Changqing Xun; Fiscal Year: 2002
    ..The long- term goals are to carry out translational studies that will lead to improvements in the treatment of cancer and other diseases with stem cell transplantation. ..
  48. Regulation of Class I Gene Expressions in Tumor Cells
    GORDON GINDER; Fiscal Year: 2005
    ....
  49. Functional Studies of gp42 and HLA Class 11 in EBV
    Richard Longnecker; Fiscal Year: 2006
    ..Clarifying the interactions between cellular receptors and viral glycoproteins is essential for understanding the tropisms behind EBV associated diseases. ..
  50. HEPATITIS C CLEARANCE AND HOST GENETIC FACTORS
    Chloe Thio; Fiscal Year: 2004
    ..The associations will also be assessed with regards to HCV genotype. Success is anticipated since the cohort is well-characterized, the molecular tools exist, and the collaborations have proven to be productive in HBV studies. ..
  51. HLA AS A PREDICTOR FOR STROKE IN SICKLE CELL ANEMIA
    Lori Styles; Fiscal Year: 2001
    ..Early identification of these patients would allow for preventive interventions in those at risk for stroke and avoidance of potentially toxic therapies in those at reduced risk. ..
  52. Recombinant T-cell Receptor Ligands for Treatment of Uveitis
    Grazyna Adamus; Fiscal Year: 2006
    ..To determine an effective treatment regimen for clinical rat AAU using RTLs. 2. To determine the abilities of RTLs to inhibit recurrent anterior and posterior uveitis in Lewis rats. [unreadable] [unreadable] [unreadable] [unreadable]..
  53. ALLOIMMUNIZATION TO PATERNAL LEUKOCYTES FOR HDN
    Kenneth Moise; Fiscal Year: 2002
    ..A monocyte monolayer assay will be performed using the spleens and sensitized red cells of the pups from the three serial breedings to determine the level of phagocytosis of the fetal reticuloendothelial system. ..
  54. Immunotherapy with peptide MHC tetramer isolated T cells
    Herbert Lyerly; Fiscal Year: 2005
    ..It is anticipated that these studies would provide an important proof of principle for this general concept which would have wide application for antigen specific adoptive immunotherapy of vial disorders and cancer. ..
  55. MENTAL DISORDERS OF AGING--ANTIINFLAMMATION IN AD
    Gary Small; Fiscal Year: 2003
    ....
  56. A Multi-Epitope, Analog-Based Cancer Vaccine
    Glenn Ishioka; Fiscal Year: 2004
    ..This vaccine is designed to induce T-cell responses directed against multiple TAA, in order to prevent or delay disease recurrence due to metastases. ..
  57. Role of the MHC Class II tranactivator gene in lupus and rheumatoid arthritis
    PAOLA GRASSO BRONSON; Fiscal Year: 2010
    ..A better understanding of variation within the MHC class II transactivator gene and how it influences risk and/or phenotypic expression may help lead to improved methods of diagnosis, prognosis and treatment. ..
  58. Cord Blood Expansion and Transplantation in a Nonhuman Primate Model
    Hans Peter Kiem; Fiscal Year: 2009
    ....
  59. AUTOLOGOUS MELANOMA CELL VACCINE WITH GMCSF AND IL2
    Craig Slingluff; Fiscal Year: 2001
    ..These data will then provide a foundation for subsequent rigorous evaluation of a whole cell vaccine versus vaccination with purified defined antigens. ..
  60. Novel DNA Microarray for HLA Typing
    ZUHEIR AWDEH; Fiscal Year: 2006
    ..The HLA-Microarray product will have immediate commercial utility in clinical laboratories supporting bone marrow and organ transplantation programs. ..
  61. HIV-SPECIFIC CD8+ T CELLS--FREQUENCIES AND PHENOTYPES
    John Altman; Fiscal Year: 2001
    ..Finally, the repertoire of the antigen-specific populations as a function of time following viral load reduction will be monitored over time by T cell receptor spectratyping analysis of magnetically sorted antigen specific cells. ..
  62. HUMAN/HUMANIZED T CELL RESPONSE TO ISLET CELL ANTIGENS
    Paul Lehmann; Fiscal Year: 1999
    ..By further expanding the limits of T cell diagnostics, this proposal provides the tools and the initial measurements required to understand the very cells that mediate the disease and thereby foster new therapeutic controls. ..
  63. Effects of HLA and KIR genotype on HIV and HCV
    Howard Strickler; Fiscal Year: 2006
    ..WlHS is a large, racially and geographically diverse cohort of HIV(+) (n=2761 with - 40% HCV(+)), and HIV(-) women who share similar risk factors (n=942 with - 25%HCV(+)). ..
  64. T1D Tolerance Induction with Natural Treg Epitopes
    Anne De Groot; Fiscal Year: 2009
    ..and PPI-specific immune responses in NOD mice and (3) Elucidate the mechanism of Tregitopeinduced PPI ASATI in DR4 transgenic mice...
  65. A Novel MALDI-TOF Assay for Rapid KIR Complex Sequencing
    Kathleen Houtchens; Fiscal Year: 2005
    ....