HLX

Summary

Gene Symbol: HLX
Description: H2.0 like homeobox
Alias: HB24, HLX1, H2.0-like homeobox protein, H2.0-like homeo box-1, H2.0-like homeobox 1, homeobox protein HB24, homeobox protein HLX1
Species: human
Products:     HLX

Top Publications

  1. Rajaraman G, Murthi P, Quinn L, Brennecke S, Kalionis B. Homeodomain protein HLX is expressed primarily in cytotrophoblast cell types in the early pregnancy human placenta. Reprod Fertil Dev. 2008;20:357-67 pubmed
    Homeobox genes are a large family of transcription factors. Of these, the HLX homeobox gene (previously known as HLX1 and HB24) is important for normal placentation...
  2. Murthi P, Doherty V, Said J, Donath S, Brennecke S, Kalionis B. Homeobox gene HLX1 expression is decreased in idiopathic human fetal growth restriction. Am J Pathol. 2006;168:511-8 pubmed
    ..Previously, we isolated the homeobox gene HLX1 and provided evidence for a regulatory role in normal placental development...
  3. Rajaraman G, Murthi P, Leo B, Brennecke S, Kalionis B. Homeobox gene HLX1 is a regulator of colony stimulating factor-1 dependent trophoblast cell proliferation. Placenta. 2007;28:991-8 pubmed
    ..Here, we use placental trophoblast cells to investigate potential downstream effector genes of CSF-1. HLX1 is a homeobox gene that controls proliferation in embryonic cell types and haematopoietic cell lineages...
  4. LE SOUEF P. Gene-environmental interaction in the development of atopic asthma: new developments. Curr Opin Allergy Clin Immunol. 2009;9:123-7 pubmed publisher
    ..Advances in knowledge of the genetics of viral defence have contributed to improved insight into asthma in children and could lead to effective new antiviral asthma therapies. ..
  5. Suttner K, Rosenstiel P, Depner M, Schedel M, Pinto L, Ruether A, et al. TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. J Allergy Clin Immunol. 2009;123:1062-8, 1068.e1-8 pubmed publisher
    ..induces the differentiation of T(H)1 and blocks T(H)2 commitment together with the homeobox transcription factor HLX1. The role of genetic variants in TBX21 alone and in combination with HLX1 polymorphisms was investigated in the ..
  6. Rajaraman G, Murthi P, Brennecke S, Kalionis B. Homeobox gene HLX is a regulator of HGF/c-met-mediated migration of human trophoblast-derived cell lines. Biol Reprod. 2010;83:676-83 pubmed publisher
    ..Our previous studies demonstrated that homeobox gene HLX is expressed in proliferating and migrating (but not invading) human trophoblast cells and that HLX expression is ..
  7. Suttner K, Ruoss I, Rosenstiel P, Depner M, Pinto L, Schedel M, et al. HLX1 gene variants influence the development of childhood asthma. J Allergy Clin Immunol. 2009;123:82-88.e6 pubmed publisher
    ..Only recently, the homeobox transcription factor H.20-like homeobox 1 (HLX1), interacting closely with T-box transcription factor, has been identified as an important regulator of T(H)1 ..
  8. Testori J, Schweighofer B, Helfrich I, Sturtzel C, Lipnik K, Gesierich S, et al. The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells. Blood. 2011;117:2735-44 pubmed publisher
    The HLX gene encoding a diverged homeobox transcription factor has been found to be up-regulated by vascular endothelial growth factor-A (VEGF-A) in endothelial cells...
  9. Zhou L, Zhang X, Zhou P, Li X, Xu X, Shi Q, et al. Effect of testosterone and hypoxia on the expansion of umbilical cord blood CD34+ cells in vitro. Exp Ther Med. 2017;14:4467-4475 pubmed publisher
    ..Therefore, the results of the current study indicate that a combination of hypoxia and testosterone may be a promising cultivation condition for HSC/hemopoietic progenitor cell expansion ex vivo...
  10. Kenig Kozlovsky Y, Scott R, Onay T, Carota I, Thomson B, Gil H, et al. Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels. J Am Soc Nephrol. 2017;: pubmed publisher
    ....

Detail Information

Publications62

  1. Rajaraman G, Murthi P, Quinn L, Brennecke S, Kalionis B. Homeodomain protein HLX is expressed primarily in cytotrophoblast cell types in the early pregnancy human placenta. Reprod Fertil Dev. 2008;20:357-67 pubmed
    Homeobox genes are a large family of transcription factors. Of these, the HLX homeobox gene (previously known as HLX1 and HB24) is important for normal placentation...
  2. Murthi P, Doherty V, Said J, Donath S, Brennecke S, Kalionis B. Homeobox gene HLX1 expression is decreased in idiopathic human fetal growth restriction. Am J Pathol. 2006;168:511-8 pubmed
    ..Previously, we isolated the homeobox gene HLX1 and provided evidence for a regulatory role in normal placental development...
  3. Rajaraman G, Murthi P, Leo B, Brennecke S, Kalionis B. Homeobox gene HLX1 is a regulator of colony stimulating factor-1 dependent trophoblast cell proliferation. Placenta. 2007;28:991-8 pubmed
    ..Here, we use placental trophoblast cells to investigate potential downstream effector genes of CSF-1. HLX1 is a homeobox gene that controls proliferation in embryonic cell types and haematopoietic cell lineages...
  4. LE SOUEF P. Gene-environmental interaction in the development of atopic asthma: new developments. Curr Opin Allergy Clin Immunol. 2009;9:123-7 pubmed publisher
    ..Advances in knowledge of the genetics of viral defence have contributed to improved insight into asthma in children and could lead to effective new antiviral asthma therapies. ..
  5. Suttner K, Rosenstiel P, Depner M, Schedel M, Pinto L, Ruether A, et al. TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. J Allergy Clin Immunol. 2009;123:1062-8, 1068.e1-8 pubmed publisher
    ..induces the differentiation of T(H)1 and blocks T(H)2 commitment together with the homeobox transcription factor HLX1. The role of genetic variants in TBX21 alone and in combination with HLX1 polymorphisms was investigated in the ..
  6. Rajaraman G, Murthi P, Brennecke S, Kalionis B. Homeobox gene HLX is a regulator of HGF/c-met-mediated migration of human trophoblast-derived cell lines. Biol Reprod. 2010;83:676-83 pubmed publisher
    ..Our previous studies demonstrated that homeobox gene HLX is expressed in proliferating and migrating (but not invading) human trophoblast cells and that HLX expression is ..
  7. Suttner K, Ruoss I, Rosenstiel P, Depner M, Pinto L, Schedel M, et al. HLX1 gene variants influence the development of childhood asthma. J Allergy Clin Immunol. 2009;123:82-88.e6 pubmed publisher
    ..Only recently, the homeobox transcription factor H.20-like homeobox 1 (HLX1), interacting closely with T-box transcription factor, has been identified as an important regulator of T(H)1 ..
  8. Testori J, Schweighofer B, Helfrich I, Sturtzel C, Lipnik K, Gesierich S, et al. The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells. Blood. 2011;117:2735-44 pubmed publisher
    The HLX gene encoding a diverged homeobox transcription factor has been found to be up-regulated by vascular endothelial growth factor-A (VEGF-A) in endothelial cells...
  9. Zhou L, Zhang X, Zhou P, Li X, Xu X, Shi Q, et al. Effect of testosterone and hypoxia on the expansion of umbilical cord blood CD34+ cells in vitro. Exp Ther Med. 2017;14:4467-4475 pubmed publisher
    ..Therefore, the results of the current study indicate that a combination of hypoxia and testosterone may be a promising cultivation condition for HSC/hemopoietic progenitor cell expansion ex vivo...
  10. Kenig Kozlovsky Y, Scott R, Onay T, Carota I, Thomson B, Gil H, et al. Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels. J Am Soc Nephrol. 2017;: pubmed publisher
    ....
  11. Schmidt K, Joyce C, Buquicchio F, Brown A, Ritz J, Distel R, et al. The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region. Cell Rep. 2016;15:2025-37 pubmed publisher
    ..Our observations directly link AR to melanoma invasion, possibly explaining why males experience more melanoma metastases and have an overall lower survival in comparison to females...
  12. Hayashi K, Ouchi M, Endou H, Anzai N. HOXB9 acts as a negative regulator of activated human T cells in response to amino acid deficiency. Immunol Cell Biol. 2016;94:612-7 pubmed publisher
    ..Thus, the morphogenetic gene plays an unexpected role in the regulation of cellular metabolism with changes in the nutrition status in human T cells. ..
  13. Coman D, Fullston T, Shoubridge C, Leventer R, Wong F, Nazaretian S, et al. X-Linked Lissencephaly With Absent Corpus Callosum and Abnormal Genitalia: An Evolving Multisystem Syndrome With Severe Congenital Intestinal Diarrhea Disease. Child Neurol Open. 2017;4:2329048X17738625 pubmed publisher
    ..R379L, was identified. This case contributes to the clinical, histological, and molecular understanding of the multisystem nature of this disorder, especially the role of ARX in the development of the enteroendocrine system...
  14. Georgiadis P, Liampa I, Hebels D, Krauskopf J, Chatziioannou A, Valavanis I, et al. Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis. BMC Genomics. 2017;18:728 pubmed publisher
    ....
  15. Kang D, Zhou G, Zhou S, Zeng J, Wang X, Jiang Y, et al. Comparative transcriptome analysis reveals potentially novel roles of Homeobox genes in adipose deposition in fat-tailed sheep. Sci Rep. 2017;7:14491 pubmed publisher
    ..Our results provide new insight into exploring the specific fat deposition in tail, also contribute to the understanding of differences between adipose depots. ..
  16. Kühn M, Song E, Feng Z, Sinha A, Chen C, Deshpande A, et al. Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. Cancer Discov. 2016;6:1166-1181 pubmed
    ..Cancer Discov; 6(10); 1166-81. ©2016 AACR.See related commentary by Hourigan and Aplan, p. 1087This article is highlighted in the In This Issue feature, p. 1069. ..
  17. Yoshihara M, Hara S, Tsujikawa M, Kawasaki S, Hayashizaki Y, Itoh M, et al. Restricted Presence of POU6F2 in Human Corneal Endothelial Cells Uncovered by Extension of the Promoter-level Expression Atlas. EBioMedicine. 2017;25:175-186 pubmed publisher
    ..These CEC-specific promoters would be useful for the assessment of fully differentiated CECs derived from pluripotent stem cells. These findings promote the development of corneal regenerative medicine. ..
  18. Kim D, Kim E, Jang W. Piperine induces osteoblast differentiation through AMPK-dependent Runx2 expression. Biochem Biophys Res Commun. 2018;495:1497-1502 pubmed publisher
    ..Finally, we confirmed that piperine induced phosphorylation of AMPK in MC3T3-E1 cells. Taken together, these results demonstrate that piperine enhance osteoblast differentiation through AMPK phosphorylation in MC3T3-E1 cells. ..
  19. Zhang J, Qu P, Zhou C, Liu X, Ma X, Wang M, et al. MicroRNA-125b is a key epigenetic regulatory factor that promotes nuclear transfer reprogramming. J Biol Chem. 2017;292:15916-15926 pubmed publisher
    ..We conclude that miR-125b promotes SCNT-mediated nuclear reprogramming by targeting SUV39H1 to decrease the deposition of repressive H3K9me3 modifications. ..
  20. Alvarez J, Furumizu C, Efroni I, Eshed Y, Bowman J. Active suppression of a leaf meristem orchestrates determinate leaf growth. elife. 2016;5: pubmed publisher
    ..This genetic framework parallels the morphogenetic program of shoot apical meristems and may represent a relic of an ancestral shoot system from which seed plant leaves evolved. ..
  21. Qin S, Ware S, Waclaw R, Campbell K. Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2. Neural Dev. 2017;12:13 pubmed publisher
    ..Finally, the septum has been suggested to be the exclusive source of CR+ interneurons in postnatal studies. Our results here demonstrate that dLGE progenitors in the embryo also contribute to this OB neuronal subtype. ..
  22. Domingo Reinés J, López Ornelas A, Montes R, Romero T, Rodriguez Llamas J, Lara Rodarte R, et al. Hoxa9 and EGFP reporter expression in human Embryonic Stem Cells (hESC) as useful tools for studying human development. Stem Cell Res. 2017;25:286-290 pubmed publisher
    ..Both transgenic cell lines maintained the pluripotent phenotype, the ability to differentiate into all three germ layers and a normal karyotype...
  23. Chen D, Sun Q, Zhang L, Zhou X, Cheng X, Zhou D, et al. The lncRNA HOXA11-AS functions as a competing endogenous RNA to regulate PADI2 expression by sponging miR-125a-5p in liver metastasis of colorectal cancer. Oncotarget. 2017;8:70642-70652 pubmed publisher
    ..Overall, we conclude that HOXA11-AS promotes liver metastasis in CRC by functioning as a miR-125a-5p sponge and describe a novel HOXA11-AS-miR-125a-5p-PADI2 regulatory network involved in CRC liver metastasis. ..
  24. Pandolfi A, Steidl U. HLX in AML: novel prognostic and therapeutic target. Oncotarget. 2012;3:1059-60 pubmed
  25. Jeffery N, Richardson S, Beall C, Harries L. The species origin of the cellular microenvironment influences markers of beta cell fate and function in EndoC-βH1 cells. Exp Cell Res. 2017;361:284-291 pubmed publisher
    ....
  26. Yuan J, Yin Z, Tao K, Wang G, Gao J. Homeobox protein CDX2 as a prognostic biomarker in solid malignancies: a meta-analysis. Oncotarget. 2017;8:89160-89172 pubmed publisher
    ..Nevertheless, its prognostic value for solid tumours requires further investigation. Hence, we conducted a meta-analysis to determine the significance of CDX2 as a prognostic biomarker in solid malignancies systematically...
  27. Zhang J, Zhou C, Jiang H, Liang L, Shi W, Zhang Q, et al. ZEB1 induces ER-α promoter hypermethylation and confers antiestrogen resistance in breast cancer. Cell Death Dis. 2017;8:e2732 pubmed publisher
    ..Therefore, our findings suggest that ZEB1 is a crucial determinant of resistance to antiestrogen therapies in breast cancer. ..
  28. Huang L, Pan D, Chen Q, Zhu L, Ou J, Wabitsch M, et al. Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation. Nat Commun. 2017;8:68 pubmed publisher
    ..Here we show that the transcription factor Hlx is selectively expressed in brown adipose tissue (BAT) and iWAT, and is translationally upregulated by β3-..
  29. Sulkava M, Raitoharju E, Mennander A, Levula M, Seppälä I, Lyytikäinen L, et al. Differentially expressed genes and canonical pathways in the ascending thoracic aortic aneurysm - The Tampere Vascular Study. Sci Rep. 2017;7:12127 pubmed publisher
    ..We propose HOX genes as potentially important players in maintaining aortic integrity, altered expression of which might be important in the pathobiology of ATAA. ..
  30. Amasdl S, Smaili W, Natiq A, Hassani A, Sbiti A, Agadr A, et al. Familial X/Y Translocation Encompassing ARSE in Two Moroccan Siblings with Sensorineural Deafness. Cytogenet Genome Res. 2017;: pubmed publisher
    ..33(2701273_3258404)×0mat,Yq11.222q12 (21412851_59310245)×2. Herein, we describe a Moroccan family with a maternally inherited X/Y translocation and discuss the genotype-phenotype correlations according to the deleted genes...
  31. Kohli V, Nardini D, Ehrman L, Waclaw R. Characterization of Glcci1 expression in a subpopulation of lateral ganglionic eminence progenitors in the mouse telencephalon. Dev Dyn. 2018;247:222-228 pubmed publisher
    ..These findings suggest that Glcci1 is a new marker of a subpopulation of LGE VZ progenitor cells in the Gsx2 lineage. Developmental Dynamics 247:222-228, 2018. © 2017 Wiley Periodicals, Inc. ..
  32. Mjomba F, Zheng Y, Liu H, Tang W, Hong Z, Wang F, et al. Homeobox Is Pivotal for OsWUS Controlling Tiller Development and Female Fertility in Rice. G3 (Bethesda). 2016;6:2013-21 pubmed publisher
    ..The results of this study suggest that the homeobox domain is pivotal for OsWUS function. ..
  33. Giampaolo A, Acampora D, Zappavigna V, Pannese M, D ESPOSITO M, Care A, et al. Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. Differentiation. 1989;40:191-7 pubmed
    ..Thus, the relative position of HOX-2 homeobox genes along the chromosome in the 5'-3' direction appears to correlate with the relative position of their expression domains along the CNS longitudinal axis in the caudal-cephalic direction...
  34. Peart N, Wagner E. A distal auxiliary element facilitates cleavage and polyadenylation of Dux4 mRNA in the pathogenic haplotype of FSHD. Hum Genet. 2017;136:1291-1301 pubmed publisher
    ..Our results underscore the complexity of the region immediately downstream of the D4Z4 and uncover a previously unknown function for the β-satellite region in Dux4 cleavage and polyadenylation. ..
  35. Mao L, Huang W, Zou P, Dang X, Zeng X. The unrecognized role of tumor suppressor genes in atrial fibrillation. Gene. 2018;642:26-31 pubmed publisher
    ....
  36. Li H, Li J, Yang T, Lin S, Li H. MicroRNA-433 Represses Proliferation and Invasion of Colon Cancer Cells by Targeting Homeobox A1. Oncol Res. 2017;: pubmed publisher
    ..To conclude, we revealed that miR-433 was downregulated in colon cancer and it inhibited colon cancer cell proliferation and invasion by directly targeting HOXA1...
  37. Chang Y, Lin C, Yu C, Wang B, Huang Y, Hsieh Y, et al. Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression. Oncotarget. 2016;7:12137-49 pubmed publisher
    ..In conclusion, our data suggest that resveratrol epigenetically inhibits ZEB1 expression to suppress the myofibroblast activity of fBMFs and may serve as a dietary supplement for OSF patients. ..
  38. Cao Y, Min J, Zhang Q, Li H, Li H. Associations of LBX1 gene and adolescent idiopathic scoliosis susceptibility: a meta-analysis based on 34,626 subjects. BMC Musculoskelet Disord. 2016;17:309 pubmed publisher
    ..Our meta-analysis provides evidence that rs111090870, rs678741 and rs625039 polymorphisms near LBX1 gene are associated with AIS susceptibility in some populations. However, our findings are based on only a limited number of studies. ..
  39. Liu T, Chen J, Xiao S, Lei X. H2.0-like homeobox 1 acts as a tumor suppressor in hepatocellular carcinoma. Tumour Biol. 2016;37:6419-28 pubmed publisher
    H2.0-like homeobox 1 (HLX1) is a homeobox transcription factor gene expressed primarily in cytotrophoblast cell types in the early pregnancy human placenta and involved in the development of enteric nervous system...
  40. Nguyen M, Singhal P, Piet J, Shefelbine S, Maden M, Voss S, et al. Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl. Development. 2017;144:601-611 pubmed publisher
    ....
  41. Kouwenhoven W, von Oerthel L, Smidt M. Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool. PLoS ONE. 2017;12:e0182421 pubmed publisher
    ..Thus we reveal in this manuscript that regulated levels of Pitx3 and En1 control the size and rostral/caudal-identity of the mdDA neuronal population. ..
  42. Mansour M, Senga T. HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer. Int J Biochem Cell Biol. 2017;88:1-13 pubmed publisher
    ..We demonstrated the ability of HOXD8 to upregulate executioner caspases 6 & 7 and cleaved PARP, thus inducing the apoptotic events in colorectal cancer cells. ..
  43. Pan C, Gao H, Zheng N, Gao Q, Si Y, Zhao Y. MiR-320 inhibits the growth of glioma cells through downregulating PBX3. Biol Res. 2017;50:31 pubmed publisher
    ..MiR-320 may suppress glioma cells growth and induced apoptosis through the PBX3/Raf-1/MAPK axis, and miR-320 oligonucleotides may be a potential cancer therapeutic for glioma. ..
  44. Guan C, Wu B, Yu T, Wang Q, Krogan N, Liu X, et al. Spatial Auxin Signaling Controls Leaf Flattening in Arabidopsis. Curr Biol. 2017;27:2940-2950.e4 pubmed publisher
    ..Taken together, these findings explain how adaxial-abaxial polarity patterns the mediolateral axis and subsequent lateral expansion of leaves. ..
  45. Delgado R, Lim D. Maintenance of Positional Identity of Neural Progenitors in the Embryonic and Postnatal Telencephalon. Front Mol Neurosci. 2017;10:373 pubmed publisher
    ..Finally, we speculate about the role of mammalian PcG and trxG factors in the long-term maintenance of NPC positional identity and certain neurodevelopmental disorders...
  46. Capowski E, Wright L, Liang K, Phillips M, Wallace K, Petelinsek A, et al. Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells. Stem Cells. 2016;34:2625-2634 pubmed publisher
    ..Stem Cells 2016;34:2625-2634...
  47. Saito M, Okayama H, Saito K, Ando J, Kumamoto K, Nakamura I, et al. CDX2 is involved in microRNA-associated inflammatory carcinogenesis in gastric cancer. Oncol Lett. 2017;14:6184-6190 pubmed publisher
    ..In conclusion, CDX2 may be a useful prognostic biomarker for gastric cancer and is associated with p53 inactivation...
  48. Li X, Xu G, Zhai Z, Gao C, Yan H, Xi Q, et al. CDX2 increases SLC7A7 expression and proliferation of pig intestinal epithelial cells. Oncotarget. 2016;7:30597-609 pubmed publisher
    ..Our findings show that nutrient transporters are activated during CDX2-induced proliferation of normal intestinal epithelial cells. ..
  49. Deguchi Y, Kirschenbaum A, Kehrl J. A diverged homeobox gene is involved in the proliferation and lineage commitment of human hematopoietic progenitors and highly expressed in acute myelogenous leukemia. Blood. 1992;79:2841-8 pubmed
    b>HB24 is a diverged homeobox gene known to be expressed in hematopoietic progenitor cells...
  50. Marchini A, Ogata T, Rappold G. A Track Record on SHOX: From Basic Research to Complex Models and Therapy. Endocr Rev. 2016;37:417-48 pubmed publisher
    ..Here, we summarize recent data and give insight into the critical molecular and cellular functions of SHOX in the etiopathogenesis of short stature and limb development. ..
  51. Ezashi T, Imakawa K. Transcriptional control of IFNT expression. Reproduction. 2017;154:F21-F31 pubmed publisher
    ..Altogether, the studies of transcriptional control of IFNT have provided mechanistic evidence of the regulatory framework of trophoblast-specific expression and critical expression pattern for maternal recognition of pregnancy...
  52. Zhou S, Jiang W, Long F, Cheng S, Yang W, Zhao Y, et al. Rice Homeodomain Protein WOX11 Recruits a Histone Acetyltransferase Complex to Establish Programs of Cell Proliferation of Crown Root Meristem. Plant Cell. 2017;29:1088-1104 pubmed publisher
    ....
  53. Ramberg H, Grytli H, Nygard S, Wang W, Ogren O, Zhao S, et al. PBX3 is a putative biomarker of aggressive prostate cancer. Int J Cancer. 2016;139:1810-20 pubmed publisher
    ..46-0.93, p values < 0.001, and AUC = 0.75). Our findings strongly indicate that PBX3 has potential as a biomarker, both as part of a larger gene panel and as an immunohistochemical marker, for aggressive prostate cancer...
  54. Ma H, Su L, Zhang S, Kung H, Miao J. Inhibition of ANXA7 GTPase activity by a small molecule promotes HMBOX1 translation of vascular endothelial cells in vitro and in vivo. Int J Biochem Cell Biol. 2016;79:33-40 pubmed publisher
    ..Besides, our data suggested that HMBOX1 might be a novel diagnostic marker and therapeutic target of atherosclerosis. ..
  55. Okello D, Iyyanar P, Kulyk W, Smith T, Lozanoff S, Ji S, et al. Six2 Plays an Intrinsic Role in Regulating Proliferation of Mesenchymal Cells in the Developing Palate. Front Physiol. 2017;8:955 pubmed publisher
    ..Our findings demonstrate that Six2 functions downstream of Hoxa2 as a positive regulator of mesenchymal cell proliferation during SP development. ..
  56. Shi M, Hu X, Wei Y, Hou X, Yuan X, Liu J, et al. Genome-Wide Profiling of Small RNAs and Degradome Revealed Conserved Regulations of miRNAs on Auxin-Responsive Genes during Fruit Enlargement in Peaches. Int J Mol Sci. 2017;18: pubmed publisher
    ..Our systematic profiling of miRNAs and the degradome in peach fruit suggests the existence of a post-transcriptional regulation network of miRNAs that target auxin pathway genes in fruit development. ..
  57. Chaudhry A, Chung B, Stavropoulos D, Araya M, Ali A, Heon E, et al. Agenesis of the corpus callosum, developmental delay, autism spectrum disorder, facial dysmorphism, and posterior polymorphous corneal dystrophy associated with ZEB1 gene deletion. Am J Med Genet A. 2017;173:2467-2471 pubmed publisher
    ..To our best knowledge this is the first reported case with a deletion of the ZEB1 gene in an individual with ACC and PPD, showing that the haploinsufficiency of the ZEB1 is likely the cause of our patient's phenotype. ..
  58. Wang Y, Liu F, Sherwin S, Farrelly M, Yan X, Croft A, et al. Cooperativity of HOXA5 and STAT3 is critical for HDAC8 inhibition-mediated transcriptional activation of PD-L1 in human melanoma cells. J Invest Dermatol. 2017;: pubmed publisher
    ..Collectively, these results identify HDAC8 as an important epigenetic regulator of PD-L1 expression, with implications for better understanding of the interaction between melanoma cells and the immune system...
  59. Tang F, Chen N, Zhao M, Wang Y, He R, Peng X, et al. Identification and Functional Divergence Analysis of WOX Gene Family in Paper Mulberry. Int J Mol Sci. 2017;18: pubmed publisher
    ..Our work will benefit the systematic understanding of the precise function of WOX in plant development and environmental stress responses. ..
  60. Mato E, Lucas M, Petriz J, Gomis R, Novials A. Identification of a pancreatic stellate cell population with properties of progenitor cells: new role for stellate cells in the pancreas. Biochem J. 2009;421:181-91 pubmed publisher
    ..Although the potential therapeutic application remains to be tested, PaSCs could represent a future option for insulin replacement in diabetes research...
  61. Rajaei B, Shamsara M, Sanati M. In Vitro Generation of Glucose-Responsive Insulin-Secreting Cells from Pancreatic and Duodenal Homeobox 1-Overexpressing Human-Induced Pluripotent Stem Cell Derived from Diabetic Patient. ASAIO J. 2017;: pubmed publisher
    ..These cells are an invaluable source for disease modeling, drug discovery, and pharmacogenomics studies as well...
  62. Tucker M, Sieber M, Morphew M, Han M. The Caenorhabditis elegans aristaless orthologue, alr-1, is required for maintaining the functional and structural integrity of the amphid sensory organs. Mol Biol Cell. 2005;16:4695-704 pubmed
    ..Genetic interaction tests also suggest that ALR-1 may function cooperatively with the cell adhesion processes in maintaining the amphid sensory organs...