homeobox

Summary

Gene Symbol: homeobox
Description: ladybird homeobox 1
Alias: HPX-6, HPX6, LBX1H, homeobox, transcription factor LBX1, lady bird-like homeobox, ladybird homeobox homolog 1, ladybird homeobox protein homolog 1, transcription factor similar to D. melanogaster homeodomain protein lady bird late
Species: human

Top Publications

  1. ncbi Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes
    K Jagla
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, Strasbourg, France
    Mech Dev 53:345-56. 1995
  2. doi A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis
    Yohei Takahashi
    Laboratory of Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, Tokyo, Japan
    Nat Genet 43:1237-40. 2011
  3. doi SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese
    Yan Hui Fan
    Department of Biochemistry, University of Hong Kong, Hong Kong, China
    J Hum Genet 57:244-6. 2012
  4. pmc Association between common variants near LBX1 and adolescent idiopathic scoliosis replicated in the Chinese Han population
    Wenjie Gao
    Department of Orthopedic Surgery, the First Affiliated Hospital of Sun Yat Sen University, Guangdong, China
    PLoS ONE 8:e53234. 2013
  5. doi A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups
    Douglas Londono
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, USA
    J Med Genet 51:401-6. 2014
  6. ncbi Scoliosis and developmental theory: adolescent idiopathic scoliosis
    C J Goldberg
    Children s Research Center, Our Lady s Hospital for Sick Children, Dublin, Ireland
    Spine (Phila Pa 1976) 22:2228-37; discussion 2237-8. 1997
  7. ncbi Transcription factors contributing to the pancreatic beta-cell phenotype
    O D Madsen
    Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    Horm Metab Res 29:265-70. 1997
  8. ncbi Construction and analysis of a sequence-ready map in 4q25: Rieger syndrome can be caused by haploinsufficiency of RIEG, but also by chromosome breaks approximately 90 kb upstream of this gene
    R H Flomen
    School of Pharmacy, University of London, 29 39 Brunswick Square, London, WC1N 1AX, United Kingdom
    Genomics 47:409-13. 1998
  9. ncbi The homeobox gene MEIS1 is amplified in IMR-32 and highly expressed in other neuroblastoma cell lines
    T A Jones
    Human Cytogenetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK
    Eur J Cancer 36:2368-74. 2000
  10. ncbi The nuclear receptor transcription factor, retinoid-related orphan receptor beta, regulates retinal progenitor proliferation
    L Chow
    Program in Neurobiology, University of Washington, Seattle, WA 98195, USA
    Mech Dev 77:149-64. 1998

Research Grants

  1. Role of the cdx homeobox genes in the regulation of wt1 and nephron development
    Alan J Davidson; Fiscal Year: 2010
  2. HOMEBOX GENES AND NEURONAL DIFFERENTIATION
    GABRIEL AISEMBERG; Fiscal Year: 2002
  3. Soumen Paul; Fiscal Year: 2014
  4. VISUAL NEURONS--DEVELOPMENT AND REGENERATION IN VITRO
    MARIA VALERIA CANTO SOLER; Fiscal Year: 2010
  5. Regulation and Function of the Rhox8 homeobox gene in granulosa cells
    JAMES ARTHUR MACLEAN; Fiscal Year: 2010
  6. Stem cell manipulation via HOX gene regulation
    Stephen G Emerson; Fiscal Year: 2010
  7. Basis for Lymphomagenesis in Akt2 Transgenic Mice
    Joseph R Testa; Fiscal Year: 2013
  8. Jenean O'Brien; Fiscal Year: 2015
  9. WILLIAM JAMES MCGINNIS; Fiscal Year: 2015
  10. The Role of Iroquois Homeobox Genes in Vasculogenesis
    Leonard M Anderson; Fiscal Year: 2010

Detail Information

Publications745 found, 100 shown here

  1. ncbi Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes
    K Jagla
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, Strasbourg, France
    Mech Dev 53:345-56. 1995
    We have cloned two novel homeobox genes which are the mouse (Lbx1) and human (LBX1) homologs of the Drosophila lady bird genes. They are highly related not only within the coding region but also in 5' and 3' untranslated regions...
  2. doi A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis
    Yohei Takahashi
    Laboratory of Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, Tokyo, Japan
    Nat Genet 43:1237-40. 2011
    ..24 × 10(-19); odds ratio (OR) = 1.56) is located near LBX1 (encoding ladybird homeobox 1)...
  3. doi SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese
    Yan Hui Fan
    Department of Biochemistry, University of Hong Kong, Hong Kong, China
    J Hum Genet 57:244-6. 2012
    ..We employed case-control analysis to study the association of SNP rs11190870 near LBX1 (ladybird homeobox 1) with AIS in a southern Chinese population...
  4. pmc Association between common variants near LBX1 and adolescent idiopathic scoliosis replicated in the Chinese Han population
    Wenjie Gao
    Department of Orthopedic Surgery, the First Affiliated Hospital of Sun Yat Sen University, Guangdong, China
    PLoS ONE 8:e53234. 2013
    ..This study suggests a novel AIS predisposition candidate gene and supports the hypothesis that somatosensory functional disorders could contribute to the pathogenesis of AIS. These findings warrant replication in other populations...
  5. doi A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups
    Douglas Londono
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, USA
    J Med Genet 51:401-6. 2014
    ..To extend this result, and to create larger AIS cohorts for the purpose of large-scale meta-analyses in multiple ethnicities, we formed a collaborative group called the International Consortium for Scoliosis Genetics (ICSG)...
  6. ncbi Scoliosis and developmental theory: adolescent idiopathic scoliosis
    C J Goldberg
    Children s Research Center, Our Lady s Hospital for Sick Children, Dublin, Ireland
    Spine (Phila Pa 1976) 22:2228-37; discussion 2237-8. 1997
    ..The morphologic genome can be viewed as a cybernetic control system, and the homeobox genes can be viewed as the master controls for the specific subroutines...
  7. ncbi Transcription factors contributing to the pancreatic beta-cell phenotype
    O D Madsen
    Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    Horm Metab Res 29:265-70. 1997
    Insulin promoter factor-1 (IPF1) (renamed to pancreatic-duodenal homeobox factor-1, PDX1) was originally cloned and characterized as an islet beta-cell specific insulin gene transcription factor (1) and later shown to be essential for the ..
  8. ncbi Construction and analysis of a sequence-ready map in 4q25: Rieger syndrome can be caused by haploinsufficiency of RIEG, but also by chromosome breaks approximately 90 kb upstream of this gene
    R H Flomen
    School of Pharmacy, University of London, 29 39 Brunswick Square, London, WC1N 1AX, United Kingdom
    Genomics 47:409-13. 1998
    ..Recently, a bicoid-related homeobox transcription factor gene called RIEG has been cloned, characterized, and proven to cause the 4q25 linked RIEG...
  9. ncbi The homeobox gene MEIS1 is amplified in IMR-32 and highly expressed in other neuroblastoma cell lines
    T A Jones
    Human Cytogenetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK
    Eur J Cancer 36:2368-74. 2000
    ..of amplification from the short arm of chromosome 2 in the neuroblastoma cell line IMR-32 and found that the homeobox gene, myeloid ecotropic integration site 1 (MEIS1), is highly amplified...
  10. ncbi The nuclear receptor transcription factor, retinoid-related orphan receptor beta, regulates retinal progenitor proliferation
    L Chow
    Program in Neurobiology, University of Washington, Seattle, WA 98195, USA
    Mech Dev 77:149-64. 1998
    ..I., Roderick, T.H., Taylor, B.A., Hankin, M.H. and McInnes, R.R., 1996. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation...
  11. ncbi CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway
    Y Zou
    American Heart Association Bugher Foundation Center for Molecular Biology, Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    Development 124:793-804. 1997
    ..by both whole-mount in situ hybridizations and RNase protection assays, suggesting that carp is downstream of the homeobox gene Nkx2-5 in the cardiac regulatory network...
  12. ncbi Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape
    A Mackenzie
    Department of Cell and Structural Biology, University of Manchester, UK
    Development 115:403-20. 1992
    We have studied the expression patterns of the newly isolated homeobox gene, Hox-8 by in situ hybridisation to sections of the developing heads of mouse embryos between E9 and E17...
  13. pmc Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation
    O Lorentz
    Institut National de la Sante et de la Recherche Medicale, Unité 381, 67200 Strasbourg, France
    J Cell Biol 139:1553-65. 1997
    To explore the role of homeobox genes in the intestine, the human colon adenocarcinoma cell line Caco2-TC7 has been stably transfected with plasmids synthesizing Cdx1 and Cdx2 sense and antisense RNAs...
  14. ncbi The evolution of Msx gene function: expression and regulation of a sea urchin Msx class homeobox gene
    S L Dobias
    Department of Biochemistry and Molecular Biology, University of Southern California School of Medicine, Los Angeles 90033, USA
    Mech Dev 61:37-48. 1997
    Msx- class homeobox genes, characterized by a distinct and highly conserved homeodomain, have been identified in a wide variety of metazoans from vertebrates to coelenterates...
  15. pmc Activation of the cytotactin promoter by the homeobox-containing gene Evx-1
    F S Jones
    Laboratory of Developmental and Molecular Biology, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 89:2091-5. 1992
    ..To determine the effects of homeobox-containing genes on cytotactin promoter activity, we conducted a series of cotransfection experiments on NIH 3T3 ..
  16. ncbi Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli
    G B Godbole
    National Institute for Research in Reproductive Health, Indian Council of Medical Research, JM Street, Parel, Mumbai 400012, India
    Reproduction 134:513-23. 2007
    b>Homeobox A10 (HOXA10), a member of abdominal B subclass of homeobox genes, is responsible for uterine homeosis during development...
  17. pmc Early evolution of the LIM homeobox gene family
    Mansi Srivastava
    Center for Integrative Genomics and Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
    BMC Biol 8:4. 2010
    LIM homeobox (Lhx) transcription factors are unique to the animal lineage and have patterning roles during embryonic development in flies, nematodes and vertebrates, with a conserved role in specifying neuronal identity...
  18. ncbi Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
    Reginald V N Lord
    Department of Surgery, University of Southern California Keck School of Medicine Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    Surgery 138:924-31. 2005
    The CDX2 (caudal-related homeobox gene 2) and PITX1 (pituitary homeobox 1) genes have essential roles in human development. Forced expression of Cdx2 alone in the murine stomach results in gastric intestinal metaplasia (IM)...
  19. ncbi Normal expression and the effects of ectopic expression of the Drosophila muscle segment homeobox (msh) gene suggest a role in differentiation and patterning of embryonic muscles
    P C Lord
    Department of Biochemistry M C 536, University of Illinois, College of Medicine, Chicago 60612, USA
    Dev Biol 171:627-40. 1995
    ..and expression pattern of a cDNA clone encoded by the previously uncharacterized Drosophila muscle segment homeobox (msh) gene and its possible role in myogenesis...
  20. pmc A homeobox gene with potential developmental control function in the meristem of the conifer Picea abies
    A Sundås-Larsson
    Department of Physiological Botany, Uppsala University, Villavagen 6, S 752 36, Uppsala, Sweden
    Proc Natl Acad Sci U S A 95:15118-22. 1998
    Many homeobox genes control essential developmental processes in animals and plants. In this report, we describe the first cDNA corresponding to a homeobox gene isolated from a gymnosperm, the HBK1 gene from the conifer Picea abies (L...
  21. ncbi A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila
    R Bodmer
    Howard Hughes Medical Institute, San Francisco, CA
    Development 110:661-9. 1990
    Many homeobox-containing genes of Drosophila regulate pathways of differentiation. These proteins probably function as promoter- or enhancer-selective transcription factors...
  22. ncbi A homeobox gene involved in node, notochord and neural plate formation of chick embryos
    S Stein
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Zellbiologie, Gottingen, Germany
    Mech Dev 49:37-48. 1995
    We have isolated a chicken cDNA clone, Cnot, resembling in sequence and expression pattern the Xenopus homeobox gene Xnot...
  23. ncbi Initiation of anterior head-specific gene expression in uncommitted ectoderm of Xenopus laevis by ammonium chloride
    P H Mathers
    Laboratory of Developmental Biology, CBER, FDA, Rockville, Maryland 20852 1448, USA
    Dev Biol 171:641-54. 1995
    The role of homeobox-containing genes in the regional specification of the vertebrate embryo has been an area of intense research over the last decade...
  24. ncbi Immunocytochemical detection of the homeobox B3, B4, and C6 gene products in childhood medulloblastomas/primitive neuroectodermal tumors
    B Bodey
    Department of Pathology, University of Southern California, Los Angeles 91335, USA
    Anticancer Res 20:1769-80. 2000
    The homeobox was originally described as a conserved DNA motif of about 180 base pairs. The protein domain encoded by the homeobox, the homeodomain, is thus about 60 amino acids long...
  25. ncbi Pem: a testosterone- and LH-regulated homeobox gene expressed in mouse Sertoli cells and epididymis
    J S Lindsey
    Molecular Microbiology and Immunology Graduate Program, Oregon Health Sciences University, Portland 97201, USA
    Dev Biol 179:471-84. 1996
    ..In this study we examined the regulation and expression of an orphan homeobox gene, Pem, which encodes a homeodomain related to those in the Prd/Pax gene family...
  26. ncbi The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus
    Thomas R Burglin
    Department of Biosciences at Novum, Karolinska Institutet, Södertörns högskola, Alfred Nobels alle 7, 141 89 Huddinge, Sweden
    Dev Genes Evol 213:50-2. 2003
    b>Homeobox genes have been found in animals, fungi, and plants. Recently, the complete genomic sequence of Encephalitozoon cuniculi has become available and it was shown that this Microsporida species is related to fungi...
  27. pmc Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates
    Karl R Wotton
    King s College London, Department of Craniofacial Development, Floor 27 Guy s Tower, Guy s Hospital, London Bridge, London, SE1 9RT, UK
    BMC Evol Biol 8:171. 2008
    Lbx/ladybird genes originated as part of the metazoan cluster of Nk homeobox genes...
  28. ncbi Expression of the chicken homeobox-containing gene GHox-8 during embryonic chick limb development
    C N Coelho
    Department of Anatomy, School of Medicine, University of Connecticut Health Center, Farmington 06030
    Mech Dev 34:143-54. 1991
    b>Homeobox-containing genes are thought to be involved in the regulation of pattern formation and specification of positional information during vertebrate limb development...
  29. ncbi Aaknox1, a kn1-like homeobox gene in Acetabularia acetabulum, undergoes developmentally regulated subcellular localization
    K A Serikawa
    Department of Biochemistry, University of Washington, Seattle 98195, USA
    Plant Mol Biol 41:785-93. 1999
    b>Homeobox-containing genes play developmentally important roles in a wide variety of plants, animals and fungi...
  30. ncbi Early embryonic expression of a LIM-homeobox gene Cs-lhx3 is downstream of beta-catenin and responsible for the endoderm differentiation in Ciona savignyi embryos
    Y Satou
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 128:3559-70. 2001
    ..We found that a LIM-homeobox gene (Cs-lhx3), an otx homolog (Cs-otx) and an NK-2 class gene (Cs-ttf1) were among beta-catenin downstream genes...
  31. ncbi Expression of HOX gene products in normal and abnormal trophoblastic tissue
    Lawrence S Amesse
    Department of Obstetrics and Gynecology, Wright State University School of Medicine, Dayton, OH 45409, USA
    Gynecol Oncol 90:512-8. 2003
    The expression pattern of three homeobox genes products, HOX A11, HOX B6, and HOX C6, was examined in normal human placental tissue and abnormal trophoblastic tissue derived from complete hydatidiform moles and choriocarcinoma tumors...
  32. ncbi Regulation of the Rhox5 homeobox gene in primary granulosa cells: preovulatory expression and dependence on SP1/SP3 and GABP
    James A Maclean
    Department of Immunology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Biol Reprod 73:1126-34. 2005
    b>Homeobox genes encode transcription factors that regulate embryonic development and postnatal events...
  33. pmc Bile acids directly augment caudal related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett's epithelium
    H Kazumori
    Department of Gastroenterology and Hepatology, Shimane University, School of Medicine, 89 1 Enya cho, Izumo, Shimane 693 8501, Japan
    Gut 55:16-25. 2006
    ..We investigated the effects of various bile acids on expression of the caudal related homeobox gene Cdx2 in cultured oesophageal squamous epithelial cells...
  34. doi Altered HBK3 expression affects glutathione and ascorbate metabolism during the early phases of Norway spruce (Picea abies) somatic embryogenesis
    Mark F Belmonte
    Dept Plant Science, University of Manitoba, Winnipeg, R3T 2N2 Manitoba, Canada
    Plant Physiol Biochem 47:904-11. 2009
    Plant homeobox genes play an important role in plant development, including embryogenesis. Recently, the function of a class I homeobox of knox 3 gene, HBK3, has been characterized in the conifer Picea abies (L.) Karst (Norway spruce) [8]...
  35. ncbi The pattern of expression of the chicken homolog of HOX1I in the developing limb suggests a possible role in the ectodermal inhibition of chondrogenesis
    B Rogina
    Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030
    Dev Dyn 193:92-101. 1992
    b>Homeobox-containing genes have been implicated in a variety of patterning events during vertebrate limb development...
  36. ncbi Identification of a retinoic acid responsive enhancer 3' of the murine homeobox gene Hox-1.6
    A W Langston
    Cell and Developmental Biology Program, Harvard Medical School, Boston
    Mech Dev 38:217-27. 1992
    The putative vertebrate morphogen retinoic acid (RA) has been shown to induce expression of many mammalian homeobox genes in cell lines, suggesting expression of this gene family in developing vertebrate embryos may be controlled in part ..
  37. ncbi Presence of isl-1-related LIM domain homeobox genes in teleost and their similar patterns of expression in brain and spinal cord
    Z Gong
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    J Biol Chem 270:3335-45. 1995
    Three novel LIM domain homeobox cDNAs encoding proteins structurally related to the Isl-1 protein were isolated from a chinook salmon pituitary cDNA library...
  38. ncbi Physical linkage of the murine Hox-b cluster and nerve growth factor receptor on yeast artificial chromosomes
    K L Bentley
    Department of Biology, Yale University, New Haven, Connecticut 06511
    Genomics 18:43-53. 1993
    Evidence derived from sequence comparisons and the genomic organization of the murine Antennapedia-class homeobox gene clusters suggest that they arose from a primordial cluster through a process of gene duplication and divergence ..
  39. ncbi Craniofacial abnormalities induced by the ectopic expression of homeobox genes
    J Whiting
    Department of Craniofacial Development, UMDS, Guy s Hospital, London, UK
    Mutat Res 396:97-112. 1997
    In this paper I have tried to bring together work that highlights the role of homeobox genes in generating craniofacial form...
  40. ncbi Mezzo, a paired-like homeobox protein is an immediate target of Nodal signalling and regulates endoderm specification in zebrafish
    Morgane Poulain
    UMR 7009 CNRS, Universite de Paris VI, Observatoire Oceanologique, 06230 Villefranche sur Mer, France
    Development 129:4901-14. 2002
    ..We show that Mezzo, a novel paired-like homeobox protein, may be this missing transcription factor...
  41. ncbi The homeobox transcription factor Barx2 regulates chondrogenesis during limb development
    Robyn Meech
    The Neurosciences Institute 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Development 132:2135-46. 2005
    ..factors involved in regulation of chondrogenesis, bone morphogenetic proteins (BMPs) and members of the Sox and homeobox transcription factor families have been shown to have crucial roles...
  42. doi Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas
    Volker Fendrich
    Department of Surgery, Philipps University Marburg, Baldingerstrasse, D 35043 Marburg, Germany
    Endocr Relat Cancer 16:613-22. 2009
    ..The reason therefore is unclear. The transcription factor pancreatic-duodenal homeobox 1 (Pdx1) is important in differentiation and development of the pancreas and duodenum...
  43. ncbi The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas
    Vassil Kaimaktchiev
    OHSU Cancer Institute and Department of Pathology, Oregon Health and Science University, Portland, OR 97239, USA
    Mod Pathol 17:1392-9. 2004
    CDX2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestines...
  44. ncbi The ascidian homolog of the vertebrate homeobox gene Rx is essential for ocellus development and function
    Salvatore D'Aniello
    Neurobiology Laboratory, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Differentiation 74:222-34. 2006
    ..We have isolated a Ciona homeobox gene (Ci-Rx) that belongs to the paired-like class of homeobox genes...
  45. pmc Empty spiracles, a gap gene containing a homeobox involved in Drosophila head development
    U Walldorf
    Department of Cell Biology, University of Basel, Switzerland
    EMBO J 11:2247-59. 1992
    ..We have isolated a homeobox-containing gene, W13, by cross-homology using the Drosophila muscle segment homeobox gene (msh) as a probe...
  46. ncbi Characterization of the homeobox-containing gene GH6 identifies novel regions of homeobox gene expression in the developing chick embryo
    H S Stadler
    Department of Biological Sciences, University of Iowa, Iowa City 52242
    Dev Biol 161:251-62. 1994
    b>Homeobox genes are a major group of genes involved in regulating, embryogenesis...
  47. ncbi Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype
    V Castronovo
    Metastasis Research Laboratory, University of Liege, Belgium
    Biochem Pharmacol 47:137-43. 1994
    ..b>Homeobox genes are a family of transcription factors that contain a 183 bp highly conserved nucleotide sequence coding for ..
  48. pmc Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells
    J M Miano
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Proc Natl Acad Sci U S A 93:900-5. 1996
    ..b>Homeobox genes exemplify one class of transcription factors that could govern smooth muscle cell phenotypic diversity...
  49. pmc Classification and nomenclature of all human homeobox genes
    Peter W H Holland
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    BMC Biol 5:47. 2007
    The homeobox genes are a large and diverse group of genes, many of which play important roles in the embryonic development of animals...
  50. doi Novel homeobox genes are differentially expressed in placental microvascular endothelial cells compared with macrovascular cells
    P Murthi
    Pregnancy Research Centre, Department of Perinatal Medicine, The Royal Women s Hospital, Carlton, Victoria, Australia
    Placenta 29:624-30. 2008
    ..b>Homeobox genes are important transcription factors that regulate vascular development in embryonic and adult tissues...
  51. doi Comprehensive survey and classification of homeobox genes in the genome of amphioxus, Branchiostoma floridae
    Naohito Takatori
    Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, 1 1 Minamiohsawa, Hachiohji, Tokyo, Japan
    Dev Genes Evol 218:579-90. 2008
    The homeobox genes comprise a large and diverse gene superfamily, many of which encode transcription factors with pivotal roles in the embryonic development of animals...
  52. ncbi [Research on the differently expressed homeobox genes related to adenoid cystic carcinoma]
    Hui Xia
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 28:190-4. 2010
    To investigate the differently expressed Homeobox genes between adenoid cystic carcinoma of salivary gland and normal gland tissue, and find out the effect of homeobox genes on oncogenesis and differentiation of adenoid cystic carcinoma ..
  53. ncbi Molecular mechanisms in the control of limb regeneration: the role of homeobox genes
    D M Gardiner
    Department of Developmental and Cell Biology, University of California Irvine 92697, USA
    Int J Dev Biol 40:797-805. 1996
    ..In this article, we review data on the role of homeobox-containing genes in the regulation of limb regeneration...
  54. pmc Ol-Prx 3, a member of an additional class of homeobox genes, is unimodally expressed in several domains of the developing and adult central nervous system of the medaka (Oryzias latipes)
    J S Joly
    Laboratoire de Genetique des Poissons, Domaine de Vilvert, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Proc Natl Acad Sci U S A 94:12987-92. 1997
    ..in the course of a large-scale screen for brain cDNAs containing a highly conserved DNA binding region, the homeobox helix-three...
  55. ncbi The roles of the homeobox genes aristaless and Distal-less in patterning the legs and wings of Drosophila
    G Campbell
    Department of Genetics and Development, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, HHSC, Room 1120, New York, NY 10032, USA columbia edu
    Development 125:4483-93. 1998
    In the leg and wing imaginal discs of Drosophila, the expression domains of the homeobox genes aristaless (al) and Distal-less (Dll) are defined by the secreted signaling molecules Wingless (Wg) and Decapentaplegic (Dpp)...
  56. ncbi Sequence of a conserved region of a new sea urchin homeobox gene from the NK family
    Zuzana Smolenicka
    International Marine Centre, Localita Sa Mardini Torregrande OR, Sardinia 09072, Italy
    Cell Biol Int 27:81-7. 2003
    The partial sequence of a novel homeobox-containing gene from Paracentrotus lividus is described. Both cDNA and genomic DNA were screened using probes from the vnd/NK-2 homeobox gene found in Drosophila melanogaster...
  57. ncbi Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes
    Kenneth J Woodside
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Building 6B, Room 2B 210, 9000 Rockville Pike, Bethesda, MD 20892 2780, USA
    Gene Expr Patterns 4:315-20. 2004
    b>Homeobox genes comprise a nearly ubiquitous and highly conserved superfamily of developmental regulatory genes that encode transcription factors involved in the determination of axis and tissue identity...
  58. pmc Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis
    Ricardo D Coletta
    Department of Obstetrics and Gynecology, University of Colorado Denver, Anschutz Medical Campus, 12800 E, 19th Ave, Aurora, CO 80045, USA
    BMC Dev Biol 10:4. 2010
    The Six1 homeobox gene is highly expressed in the embryonic mammary gland, continues to be expressed in early postnatal mammary development, but is lost when the mammary gland differentiates during pregnancy...
  59. ncbi Twist-mediated activation of the NK-4 homeobox gene in the visceral mesoderm of Drosophila requires two distinct clusters of E-box regulatory elements
    Y M Lee
    Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:17531-41. 1997
    ....
  60. doi KNOX genes influence a gradient of fruit chloroplast development through regulation of GOLDEN2-LIKE expression in tomato
    Satya Swathi Nadakuduti
    Department of Horticulture, Michigan State University, East Lansing, MI, 48824, USA
    Plant J 78:1022-33. 2014
    ..of the uniform gray-green (ug) locus of tomato reveals a thus far unknown role for the Class I KNOTTED1-LIKE HOMEOBOX (KNOX) gene, TKN4, in specifying the formation of this chloroplast gradient...
  61. doi Downregulation of HNF1 homeobox B is associated with drug resistance in ovarian cancer
    Jianchao Li
    Department of Obstetrics and Gynecology, Provincial Hospital affiliated to Shandong University, Jinan, Shandong, P R China
    Oncol Rep 32:979-88. 2014
    The expression of HNF1 homeobox B (HNF1B) is associated with cancer risk in several tumors, including ovarian cancer, and its decreased expression play roles in cancer development...
  62. pmc The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling
    Bon Q Trinh
    Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 108, Houston, TX 77030, USA
    J Cell Sci 128:3055-67. 2015
    ..Here, we identify that expression of DLX4, a transcription factor encoded by a homeobox gene, increases during megakaryopoiesis but decreases during erythropoiesis...
  63. pmc Hox-1.11 and Hox-4.9 homeobox genes
    A Nazarali
    Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:2883-7. 1992
    Mouse Hox-1.11 and Hox-4.9 genes were cloned, and the nucleotide sequences of the homeobox regions were determined. In addition, nucleotide sequence analysis of the homeobox regions of cloned Hox-4.3 and Hox-4...
  64. ncbi Disruption of Msx-1 and Msx-2 reveals roles for these genes in craniofacial, eye, and axial development
    L Foerst-Potts
    Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill 27599 7090, USA
    Dev Dyn 209:70-84. 1997
    In mouse embryos, the muscle segment homeobox genes, Msx-1 and Msx-2 are expressed during critical stages of neural tube, neural crest, and craniofacial development, suggesting that these genes play important roles in organogenesis and ..
  65. ncbi Backfoot is a novel homeobox gene expressed in the mesenchyme of developing hind limb
    J Shang
    Department of Developmental Biology, Stanford University School of Medicine, California, USA
    Dev Dyn 209:242-53. 1997
    b>Homeobox genes play important roles in pattern formation during development...
  66. ncbi Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y
    K Yamada
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 707 Light Hall, Nashville, Tennessee, 37232 0615, USA
    Biochem Biophys Res Commun 261:614-21. 1999
    ..subunit as bait we isolated a cDNA that encodes most of the open reading frame of the human zinc fingers and homeobox 1 (ZHX1) protein...
  67. ncbi RINX(VSX1), a novel homeobox gene expressed in the inner nuclear layer of the adult retina
    T Hayashi
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Genomics 67:128-39. 2000
    ..Since the RINX gene is likely an ortholog of the goldfish Vsx1 gene, it has been named VSX1 by the Human Gene Nomenclature Committee...
  68. ncbi Convergence of dorsal, dpp, and egfr signaling pathways subdivides the drosophila neuroectoderm into three dorsal-ventral columns
    T Von Ohlen
    HHMI, Eugene, Oregon 97403, USA
    Dev Biol 224:362-72. 2000
    ..The earliest sign of neural DV patterning is the expression of three homeobox genes in the neuroectoderm-ventral nervous system defective (vnd), intermediate neuroblasts defective (ind), and ..
  69. ncbi Vsx1, a rapidly evolving paired-like homeobox gene expressed in cone bipolar cells
    R L Chow
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    Mech Dev 109:315-22. 2001
    ....
  70. ncbi Hmx2 homeobox gene control of murine vestibular morphogenesis
    W Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Development 128:5017-29. 2001
    ..Hmx2, a member of the Hmx homeobox gene family, is coexpressed with Hmx3 in the dorsolateral otic epithelium...
  71. ncbi Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders
    J M Brickman
    Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Development 128:5189-99. 2001
    The homeobox gene Hesx1/HESX1 has been implicated in the establishment of anterior pattern in the central nervous system (CNS) in a number of vertebrate species...
  72. pmc Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development
    Lan Chen
    Laboratory of Mammalian Genes and Development, and Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 99:14320-5. 2002
    ..Ssdp encoded by Drosophila Ssdp or mouse Ssdp1 mRNA enhances axis induction by Ldb1 in conjunction with the LIM-homeobox gene Xlim1...
  73. ncbi Regulation of shoot epidermal cell differentiation by a pair of homeodomain proteins in Arabidopsis
    Mitsutomo Abe
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060 0810, Japan
    Development 130:635-43. 2003
    ..in the shoot system of Arabidopsis: We show here that PROTODERMAL FACTOR2 (PDF2), a member of the HD-GL2 class of homeobox genes, is expressed exclusively in the L1 of shoot meristems and that recombinant PDF2 protein specifically binds ..
  74. ncbi Expression pattern of the homeobox protein NKX2-1 in the developing Xenopus forebrain
    A Gonzalez
    Departamento de Biologia Celular, Facultad de Biologia, Universidad Complutense, 28040 Madrid, Spain
    Brain Res Gene Expr Patterns 1:181-5. 2002
    ..Thus, the detailed analysis of the distribution of NKX2-1 provides the first unequivocal evidence for distinct progenitor zones within the amphibian forebrain through embryonic and larval development...
  75. pmc JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure
    Claire R Weston
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 17:1271-80. 2003
    ..of bone morphogenetic protein-4 (BMP4) and sonic hedgehog (Shh) that induces the expression of the paired-like homeobox transcription factor Pax2 and closure of the optic fissure...
  76. pmc Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts
    Tatsuya Yoshizawa
    Divisions of Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Mol Cell Biol 24:3460-72. 2004
    ..The present study demonstrates that the homeobox protein Msx2 is a key factor in suppressing those two functions...
  77. ncbi The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons
    Tetsuji Mori
    Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960 1295 Japan
    Eur J Neurosci 19:3129-41. 2004
    ..A recent report demonstrated that some BFCNs in adult rat are positive for L3/Lhx8, a LIM homeobox transcription factor...
  78. ncbi X-linked lissencephaly with abnormal genitalia associated with renal phosphate wasting
    A Hahn
    Department of Neuropediatrics, University of Giessen, Giessen, Germany
    Neuropediatrics 35:202-5. 2004
    ..lissencephaly with abnormal genitalia (XLAG) is a rare disorder caused by mutations in the aristaless-related homeobox (ARX) gene...
  79. ncbi Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor (LIF) removal
    Eduardo Martinez-Ceballos
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 280:16484-98. 2005
    b>Homeobox (Hox) genes encode a family of transcription factors that regulate embryonic patterning and organogenesis. In embryos, alterations of the normal pattern of Hox gene expression result in homeotic transformations and malformations...
  80. pmc The Caenorhabditis elegans aristaless orthologue, alr-1, is required for maintaining the functional and structural integrity of the amphid sensory organs
    Morgan Tucker
    Department of Molecular, Cellular, and Developmental Biology and Howard Hughes Medical Institute, Boulder, CO 80303, USA
    Mol Biol Cell 16:4695-704. 2005
    The homeobox-containing aristaless-related protein ARX has been directly linked to the development of a number of human disorders involving mental retardation and epilepsy and clearly plays a critical role in development of the vertebrate ..
  81. ncbi Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system
    Rosalind S E Carney
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Neurosci 26:11562-74. 2006
    ..modes, origin, and requirement of the homeodomain-containing transcription factor Gsh2 (genomic screened homeobox 2) in the development of this prominent migratory stream...
  82. ncbi Activin-betaA signaling is required for zebrafish fin regeneration
    Anna Jazwinska
    Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Curr Biol 17:1390-5. 2007
    ..Zebrafish blastemal cells express specific genes, such as the homeobox-containing transcription factors msxB and msxC, and secreted signal FGF20a...
  83. pmc Modulation of the hormone setting by Rhodococcus fascians results in ectopic KNOX activation in Arabidopsis
    Stephen Depuydt
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, Ghent University, Gent, Belgium
    Plant Physiol 146:1267-81. 2008
    ..formed upon infection resemble the leaf phenotype of transgenic plants with ectopic expression of KNOTTED-like homeobox (KNOX) genes...
  84. pmc KNOX lost the OX: the Arabidopsis KNATM gene defines a novel class of KNOX transcriptional regulators missing the homeodomain
    Enrico Magnani
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Plant Cell 20:875-87. 2008
    ..Plant KNOTTED1-like homeobox (KNOX) and animal Myeloid ecotropic viral integration site (MEIS) proteins share a TALE homeodomain and a MEINOX (..
  85. doi Epigenetic inactivation of Homeobox A5 gene in nonsmall cell lung cancer and its relationship with clinicopathological features
    Dong Sun Kim
    Department of Anatomy, Kyungpook National University, Daegu 702 422, Republic of Korea
    Mol Carcinog 48:1109-15. 2009
    ..b>Homeobox A5 (HOXA5) is a master regulator of the morphogenesis and cell differentiation to be implicated as a tumor ..
  86. doi Evolution of the Hox gene complex from an evolutionary ground state
    Walter J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse Basel, Switzerland
    Curr Top Dev Biol 88:35-61. 2009
    ..Evolution leads from the prototypic segment to segmental divergence in both the anterior and posterior direction. The most anterior head and tail segments are specified by homeobox genes localized outside of the cluster.
  87. pmc Dioxin exposure disrupts the differentiation of mouse embryonic stem cells into cardiomyocytes
    Ying Wang
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    Toxicol Sci 115:225-37. 2010
    ..We find that TCDD treatment causes expression changes in a number of homeobox genes concomitant with Ah receptor recruitment to the promoters of many of these genes, whether under naïve or ..
  88. pmc Achieving singularity in mammalian odorant receptor gene choice
    Timothy S McClintock
    Department of Physiology, University of Kentucky, 800 Rose St, Lexington, KY 40536 0298, USA
    Chem Senses 35:447-57. 2010
    ..For example, the mechanism of activation of OR gene transcription appears to work in part through a few homeobox transcription factors (Emx2, and perhaps Lhx2) and the Ebf family of transcription factors...
  89. pmc Dopamine regulates angiogenesis in normal dermal wound tissues
    Saurav Shome
    Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India
    PLoS ONE 6:e25215. 2011
    ..The underlined mechanisms have been attributed to the up-regulation of homeobox transcription factor HoxD3 and its target α5β1 integrin, which play a pivotal role in wound angiogenesis...
  90. doi Dietary folate deficiency in pseudopregnant mice has no effect on homeobox A10 promoter methylation or expression
    Chunlan Long
    Laboratory of Reproductive Biology, Chongqing Medical University, Chongqing, People s Republic of China
    Reprod Sci 19:1268-75. 2012
    ..a folate-deficient diet (FDD) alters DNA methylation in endometria of pseudopregnant mice, focusing on the homeobox A10 (Hoxa10) promoter...
  91. doi Identification of CUX1 as the recurrent chromosomal band 7q22 target gene in human uterine leiomyoma
    Eric F P M Schoenmakers
    Department of Human Genetics, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Genes Chromosomes Cancer 52:11-23. 2013
    ..We found that both chromosomal inversions target the cut-like homeobox 1 (CUX1) gene on chromosomal band 7q22...
  92. doi Engrailed homeobox transcription factors as potential markers and targets in cancer
    Sophie E McGrath
    Department of Oncology, University of Surrey, Guildford, United Kingdom
    FEBS Lett 587:549-54. 2013
    Engrailed (En) is a member of the homeobox gene family, which encodes a homeodomain-containing transcription factor that is essential during early development...
  93. doi ATML1 promotes epidermal cell differentiation in Arabidopsis shoots
    Shinobu Takada
    Department of Biological Sciences, Graduate School of Science, Osaka University, 1 1 Machikaneyama cho, Toyonaka, Osaka, Japan
    Development 140:1919-23. 2013
    ..ATML1, an Arabidopsis homeobox gene, is expressed in the outermost cell layer, beginning at an early stage of development...
  94. pmc Pulsatile exposure to simulated reflux leads to changes in gene expression in a 3D model of oesophageal mucosa
    Nicola H Green
    Kroto Research Institute, North Campus, University of Sheffield, Sheffield, UK
    Int J Exp Pathol 95:216-28. 2014
    ..that reflux exposure activates NF-κB, driving the aberrant expression of intestine-specific caudal-related homeobox (CDX) genes. However, early events in the pathogenesis of BM from normal epithelium are poorly understood...
  95. pmc The homeoprotein DLX4 stimulates NF-κB activation and CD44-mediated tumor-mesothelial cell interactions in ovarian cancer
    Dhwani Haria
    Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas
    Am J Pathol 185:2298-308. 2015
    ..We previously identified that high expression of DLX4, a transcription factor encoded by a homeobox gene, is associated with reduced survival of ovarian cancer patients...
  96. doi Beyond the meristems: similarities in the CLAVATA3 and INFLORESCENCE DEFICIENT IN ABSCISSION peptide mediated signalling pathways
    Melinka A Butenko
    Department of Biosciences, Section for Genetics and Evolutionary Biology, University of Oslo, 0316 Oslo, Norway
    J Exp Bot 66:5195-203. 2015
    ..We provide evidence for AZ cells having a meristem identity and discuss the role of identical KNOTTED-LIKE HOMEOBOX (KNOX) transcription factors in meristem maintenance and abscission...
  97. doi Fat depot-specific expression of HOXC9 and HOXC10 may contribute to adverse fat distribution and related metabolic traits
    Jakob E Brune
    IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany
    Obesity (Silver Spring) 24:51-9. 2016
    ..Here, the hypothesis that human adipose tissue (AT) expression of the developmental genes homeobox transcription factors C9 (HOXC9) and C10 (HOXC10) is fat depot-specific and related to obesity-related traits was ..
  98. pmc PCAF-mediated acetylation of transcriptional factor HOXB9 suppresses lung adenocarcinoma progression by targeting oncogenic protein JMJD6
    Junhu Wan
    Department of Anatomy, Histology and Embryology, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China
    Nucleic Acids Res 44:10662-10675. 2016
    HOXB9 is a homeobox domain-containing transcription factor, playing an important role in embryonic development and cancer progression...
  99. ncbi An anterior signalling centre in Xenopus revealed by the homeobox gene XHex
    C M Jones
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, UK
    Curr Biol 9:946-54. 1999
    Signals from anterior endodermal cells that express the homeobox gene Hex initiate development of the most rostral tissues of the mouse embryo...
  100. ncbi Are recession populations of the desert locust (Schistocerca gregaria) remnants of past swarms?
    K M Ibrahim
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Mol Ecol 9:783-91. 2000
    ..A highly variable nuclear DNA marker, a noncoding 3' end fragment of an antennapedia-class homeobox gene, was screened in locust samples from Eritrea...
  101. ncbi The Caenorhabditis elegans Six/sine oculis class homeobox gene ceh-32 is required for head morphogenesis
    C Dozier
    Division of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Dev Biol 236:289-303. 2001
    Caenorhabditis elegans has four members of the Six/sine oculis class of homeobox genes, ceh-32, ceh-33, ceh-34, and ceh-35...

Research Grants69

  1. Role of the cdx homeobox genes in the regulation of wt1 and nephron development
    Alan J Davidson; Fiscal Year: 2010
    ..This code is disrupted in embryos deficient in the homeobox transcription factor genes cdx1a and cdx4, which act as master regulators of the hox genes...
  2. HOMEBOX GENES AND NEURONAL DIFFERENTIATION
    GABRIEL AISEMBERG; Fiscal Year: 2002
    ..The main research aim of this project is to study the role of homeobox genes in neuronal differentiations...
  3. Soumen Paul; Fiscal Year: 2014
    ..For example, transcription factor caudal-type homeobox 2 (CDX2) is important for the derivation of trophectoderm and proliferation of TS cells...
  4. VISUAL NEURONS--DEVELOPMENT AND REGENERATION IN VITRO
    MARIA VALERIA CANTO SOLER; Fiscal Year: 2010
    ..which is hypothesized to act as a regulator of retinal cell differentiation through the control of the homeobox gene Pax6. Loss-of-function and gain-of-function experiments in vivo and in vitro will be used for these studies...
  5. Regulation and Function of the Rhox8 homeobox gene in granulosa cells
    JAMES ARTHUR MACLEAN; Fiscal Year: 2010
    ..Preliminary studies suggest that Rhox8 is regulated by the coordinated efforts of progesterone receptor and homeobox factors...
  6. Stem cell manipulation via HOX gene regulation
    Stephen G Emerson; Fiscal Year: 2010
    ..Biochemical and genetic experiments in many systems indicate that homeobox proteins regulate the balance between stem cells and lineage-specific cells, in many tissues...
  7. Basis for Lymphomagenesis in Akt2 Transgenic Mice
    Joseph R Testa; Fiscal Year: 2013
    ..the transcription factor Dlx5, has recently been reported in several common human cancers, suggesting that this homeobox gene may be oncogenic when expressed aberrantly...
  8. Jenean O'Brien; Fiscal Year: 2015
    ..The pro-metastatic Homeobox (Hox) transcription factor SIX1 is overexpressed in at least 10 tumor types, including RMS, where it is critical ..
  9. WILLIAM JAMES MCGINNIS; Fiscal Year: 2015
    b>Homeobox genes are an ancient family of developmental regulators that pattern animal embryos...
  10. The Role of Iroquois Homeobox Genes in Vasculogenesis
    Leonard M Anderson; Fiscal Year: 2010
    ..Based on previous evidence that the Iroquois homeobox (Irx) proteins are critical factors in a number of developmental processes, we have begun to test the hypothesis ..
  11. NANCY JOAN BOUDREAU; Fiscal Year: 2014
    ..Thus more global approaches to inhibit angiogenesis are needed. My laboratory has defined roles for the homeobox (Hox) master transcription factors, HoxD3, HoxA3 and HoxB3 in coordinately regulating endothelial cell (EC) ..
  12. Pax genes in cardiac development
    ZACHARY PAUL NEEB; Fiscal Year: 2012
    ..6kbPax3) rescues the Pax3 null phenotype. Data demonstrate that Msh homeobox protein 2 (Msx2) is transcriptionally regulated by Pax3 and failure of Msx2 transcriptional repression leads to a ..
  13. Functional Characterization of Lung Adenocarcinoma Progression and Metastasis
    MONTE MEIER WINSLOW; Fiscal Year: 2011
    ..The proposed research builds heavily on preliminary data that uncovered down-regulation of the homeobox transcription factor Nkx2-1 as an important regulator of lung tumor progression and metastasis...
  14. Joan S Jorgensen; Fiscal Year: 2016
    ..The fundamental hypothesis guiding this proposal is that Iroquois homeobox transcription factors, Irx3/5, which are tightly regulated by [unreadable]catenin, coordinate somatic cell-oocyte ..
  15. MONTE MEIER WINSLOW; Fiscal Year: 2014
    ..The proposed research builds heavily on preliminary data that uncovered down-regulation of the homeobox transcription factor Nkx2-1 as an important regulator of lung tumor progression and metastasis...
  16. Alvaro Puga; Fiscal Year: 2015
    ..environmental pollutant, mediates the aryl hydrocarbon receptor (AHR)-dependent repression of the homeobox transcription factor NKX2.5, a key determinant of cardiac morphogenesis...
  17. Regulation of insulins by the Rhox5 homeobox gene supports spermatogenesis
    James Maclean; Fiscal Year: 2009
    Project Summary Homeobox genes encode transcription factors that control a wide variety of biological events...
  18. Patrick Cahan; Fiscal Year: 2016
    ..lab first produced transplantable mouse PSC-HSCs by directed differentiation of ESCs, ectopic expression of the homeobox transcription factor HoxB4, and co-culture with OP9 stromal cells (Kyba et al 2002)...
  19. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..its nuclear exclusion, thereby altering gene expression including derepressing transcription of pancreas duodenum homeobox-1 (PDX-1)...
  20. Regulation of Rhox5 Transcriptional Elongation
    Marcy E Richardson; Fiscal Year: 2013
    ..Rhox5 is an X-linked homeobox gene whose expression is restricted to specific somatic cell types within reproductive tissues and whose absence ..
  21. Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia
    Andrew Napper; Fiscal Year: 2012
    ..MLL-AF4 recruits a complex of proteins that activate transcription of the HOX (homeobox) oncogene HOXA9, and aberrant histone methylation by the histone methyltransferase DOT1L maintains a high level ..
  22. Genetic Control of Axial Patterning in Drosophila Eye
    Amit Singh; Fiscal Year: 2010
    ..GATA-family transcription factor Pannier (Pnr), the secreted morphogen Wingless (Wg), and Iroquois (Iro-C) family homeobox proteins. In the ventral domain, a Notch ligand Serrate (Ser) and a novel protein Lobe (L) play key roles...
  23. Molecular Components Affecting Ocular Retinoid Homeostasis
    JOHANNES FRIEDERICH VONLINTIG; Fiscal Year: 2012
    ..In Aim 1, we will address the role of the intestine specific homeobox transcription factor ISX that suppresses Srb1 and Bcmo1 gene activities which respectively encode a carotenoid ..
  24. Vincent Poitout; Fiscal Year: 2015
    ..PASK) which results in diminished expression and activity of the transcription factors pancreatic-duodenal homeobox-1 (Pdx-1) and mammalian homologue of avian MafA/l-Maf (MafA), leading to decreased insulin expression via ..
  25. Regulation and Function of the Rhox5 Homeobox Gene
    MILES FROME WILKINSON; Fiscal Year: 2013
    ..the key metabolic regulators PPAR?, PGC1?, resistin, and adiponectin, as well other members of the X-linked Rhox homeobox gene cluster...
  26. Growth and Carcinogenic Potential in the Postnatal Mammary Gland
    Demetri D Spyropoulos; Fiscal Year: 2010
    ..Our published and preliminary results and those of others raise the possibility that the homeobox transcription factor HoxC6 may underlie this delayed response: 1) Mammary ductal trees in our HoxC6 deficient ..
  27. Justin P Kumar; Fiscal Year: 2016
    ..Furthermore, these genes are also implicated in tumorigenesis and numerous cancers. Six proteins serve as homeobox containing transcription factors while Eya proteins function as transcriptional co- activators and as protein ..
  28. Molecular and Genetic Regulation of Craniofacial Development
    Brian L Black; Fiscal Year: 2013
    ..The Dlx5/6 locus encodes two Distal-less related homeobox transcription factors, while the Mef2c locus encodes a MADS box transcription factor...
  29. Da Zhi Wang; Fiscal Year: 2015
    ..found that miR-208a regulates cardiac hypertrophic growth, in part, by modulating the expression level of the key homeobox transcription factor Hop and stress responsible heat shock protein 70 (Hsp70)...
  30. Mechanisms of CDX2 regulation of the IGF axis
    Duyen Dang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): PROJECT SUMMARY CDX2 is a Drosophila caudal-related homeobox transcription factor that is important for the establishment and maintenance of intestinal epithelial cells...
  31. Function of the Six and Eya Genes in Retinal Development
    JUSTIN KUMAR; Fiscal Year: 2009
    ..Furthermore, these genes are also implicated in tumorigenesis and numerous cancers. Six proteins serve as homeobox containing transcription factors while Eya proteins function as transcriptional co-activators and as protein ..
  32. Adrianna K San Roman; Fiscal Year: 2014
    ..factor for gene activation in differentiated intestinal cells is the transcription factr Cdx2 (caudal type homeobox 2), however its role in ISCs was previously unknown...
  33. Ulrich G Steidl; Fiscal Year: 2016
    ..We have recently reported that a non- clustered homeobox gene, HLX, is overexpressed in leukemic stem cells in a mouse AML model and in the vast majority (87%) of AML ..
  34. PDX-1 is a Therapeutic Target for Pancreatic Cancer
    FRANCIS CHARLES BRUNICARDI; Fiscal Year: 2012
    ..of this revised competitive renewal proposal is that the insulin transcription factor pancreatic duodenal homeobox transcription factor (PDX-1) regulates proliferation and invasion of human PC cells, which assigns a new and ..
  35. Monique Bastidas; Fiscal Year: 2014
    ..provided by applicant): This project aims to biophysically characterize the interactions of pancreas duodenum homeobox 1 (PDX1) with promoter sequences and other transcription factors...
  36. Role of MN1-TEL and MN1 in Leukemogenesis
    Gerard C Grosveld; Fiscal Year: 2010
    ..insufficient to cause hematopoietic disease, but it causes AML in mice in cooperation with overexpression of the homeobox protein HOXA9, a combination also found in t(12;22) patient samples...
  37. Mechanisms regulating hepatic specification and differentiation in zebrafish
    CHONG H SHIN; Fiscal Year: 2013
    ..Second, I will investigate how Forkhead box and Homeobox transcription factors function downstream of Bmp2b signaling to regulate liver versus pancreatic fate decision...
  38. The Role of Eya3 as a downstream target of EWS Fli1 in Ewings Sarcoma
    Tyler P Robin; Fiscal Year: 2013
    ..for DNA repair and is also found as part of a bipartite transcription factor complex with the Six family of homeobox proteins...
  39. Jay L Hess; Fiscal Year: 2015
    ..developing better therapy for the approximately 50% of acute myeloid leukemia (AML) cases that over express the homeobox transcription factor HOXA9, along with the HOX cofactor MEIS1...
  40. Mechanisms of FoxJ1 Tooth Morphogenesis
    Brad A Amendt; Fiscal Year: 2012
    ..Our transient transfection data indicates that FoxJ1 is activated by, and also physically interacts with PITX2, a homeobox transcription factor gene involved in early craniofacial/tooth development...
  41. TRANSCRIPTIONAL CONTROL OF PANCREATIC DEVELOPMENT
    Klaus H Kaestner; Fiscal Year: 2013
    ..case three genes are in the same haplotype block and thus inherited together: HHEX (Hematopoietically expressed homeobox), KIF11 (kinesin-interacting factor 11) and IDE (insulin-degrading enzyme)...
  42. Iroquois Homeobox Transcription Factors in Heart Development and Physiology
    BENOIT GAETAN BRUNEAU; Fiscal Year: 2010
    ..We hypothesize that the Iroquois homeobox (Irx) family of transcription factors are key patterning and differentiation factors that confer cell type-..
  43. Anju Vasudevan; Fiscal Year: 2015
    ..vessel network propagates in an orderly lattice pattern into the dorsal telencephalon by E11 regulated by homeobox transcription factors...
  44. John L R Rubenstein; Fiscal Year: 2016
    ..In the forebrain, the DIxl, 2, 5 & 6 homeobox genes have a central role in this process...
  45. Genetic Basis of Congenital Anophthalmia
    THOMAS M GLASER; Fiscal Year: 2013
    ..we have defined three modifiers of the mouse eyeless mutation (ey1), a recessive hypomorphic allele in the Rx homeobox gene that decreases abundance of the Rx polypeptide in the ZRDCT strain, creating a sensitized background to ..
  46. Eric D Marsh; Fiscal Year: 2014
    ..Recently, mutations in the aristaless-related homeobox gene (ARX), a developmental transcription factor, have been shown to cause X-linked infantile spasms syndrome and ..
  47. ASHLEY MARIE ECKEL; Fiscal Year: 2015
    ..HSPC) in a murine acute myeloid leukemia (AML) model, we found 4-fold upregulation of a novel non-clustered homeobox gene, H2...
  48. Shiming Chen; Fiscal Year: 2016
    ..This regulatory network is centered on the cone-rod homeobox protein CRX and incorporates both photoreceptor-specific transcription factors (TFs) and general chromatin ..
  49. Tumor repressive role of Ets2 in the intestine
    ROBERT GLEN OSHIMA; Fiscal Year: 2012
    ..It is activated by growth factor signaling pathways and contributes to the regulation of Cdx2, a homeobox regulator of both trophoblast and intestinal development...
  50. Marianna Bei; Fiscal Year: 2014
    ..Our previous studies revealed that transcription factors encoded by the Msx homeobox gene family play an important role in the development of ectodermal organs...
  51. RYAN TERRENCE WILLETT; Fiscal Year: 2014
    ..and molecular mechanism responsible for the cerebellar hypoplasia that results from removal of the engrailed (EN) homeobox transcription factors EN1 and EN2 (refered to together as EN1/2) from granule cell progenitors (GCPs) in the ..
  52. A Mouse Knock-In Model for ENGRAILED 2 Autism Susceptibility
    James H Millonig; Fiscal Year: 2010
    ..Our previous research has focused on the homeobox transcription factor ENGRAILED 2 (EN2)...
  53. Molecular control of spinal relay sensory neuron phenoypes and pain behaviors
    Qiufu Ma; Fiscal Year: 2013
    ..Subsequent genetic studies demonstrate that Tlx3, a homeobox class transcription factor, is a pivotal regulator of spinal relay sensory neurons, including specification of ..
  54. MOLECULAR BIOLOGY OF NEUROGENESIS
    Stephen T Crews; Fiscal Year: 2010
    ..PAS transcription factor complex interacts combinatorially with segment polarity gene products, HMG proteins, POU homeobox proteins and other factors to specify midline neural and glial cell fates...
  55. Rolf Bodmer; Fiscal Year: 2016
    ..In this pursuit, we have discovered that the cardiogenic network of transcription factors, encoded by homeobox-, GATA- and T-box genes (eg...
  56. Genetic Control of Early Retinal Development
    Robert M Grainger; Fiscal Year: 2010
    ..extensive examination of the regulatory elements controlling key eye gene regulation (for example, the homeobox genes Rx, Pax6 and Six3);and 4) the development of new technology for study of gene regulation and manipulating ..
  57. CHRISTOPHER VYVIAN ERIC WRIGHT; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The pancreatic duodenal homeobox 1 (Pdx1) gene encodes a transcription factor (TF) that is essential in early pancreas development and later in the formation, maintenance and activity of islet [..
  58. Genetic analysis of dopaminergic neuron specification in C.elegans
    Oliver Hobert; Fiscal Year: 2013
    ..We have obtained preliminary evidence for the involvement of other transcriptional regulators of the homeobox gene family and their cognate cis-regulatory motifs in controlling DA neuron differentiation in conjunction with ..
  59. GUILLERMO C OLIVER; Fiscal Year: 2015
    ..A conserved network of transcription factors is essential for eye formation. The homeobox-containing gene Six3 is one of the members of that complex network that regulates visual system development...
  60. EFFECT OF ETHANOL ON CELL PROLIFERATION
    Michael W Miller; Fiscal Year: 2010
    ..During their development, neural stem cells express a homeobox gene product(s), Pax6 and/or Tbr2...
  61. Functional study of novel transcriptional regulators of hematopoietic stem cells
    Shannon L McKinney-Freeman; Fiscal Year: 2012
    ..ESC-HSC can emerge from murine ESC by manipulating homeobox gene expression (e.g. HoxB4 and Cdx4) during their differentiation...
  62. Carolyn A Felix; Fiscal Year: 2014
    ..We made the striking observations that the resulting mll depletion caused not only reduced homeobox cofactor and altered cell cycle gene expression, but also overexpression and underexpression of many ..
  63. Pem Homeobox Gene Function During Spermatogenesis
    J Suzanne Lindsey; Fiscal Year: 2004
    ..The only testosterone-regulated, Sertoli cell-specific gene known to date is the Pem homeobox gene...
  64. NEW HOMEBOX GENES IN SCARLESS FETAL WOUND HEALING
    Corey Largman; Fiscal Year: 2001
    ..The principal investigator entered the field of wound research with the hypothesis that developmentally regulated homeobox genes inform normal skin formation; and thus they provide signals which mediate scarless fetal wound regeneration...
  65. HEX EXPRESSION AND REGULATION IN DEVELOPING LUNG
    CLIFFORD BOGUE; Fiscal Year: 2000
    The research goals of this proposal are to elucidate the molecular mechanisms involved in lung development. Homeobox genes, which encode proteins which function as sequence-specific DNA binding proteins, are expressed in specific temporo-..
  66. HOMEOBOX GENES AND CONGENITAL MALFORMATION OF THE LUNG
    MaryAnn Volpe; Fiscal Year: 2002
    DESCRIPTION: (Provided by Applicant): The objective of this proposal is to develop new data showing that the homeobox gene, Hoxb-5, is necessary for normal cellular and matrix interactions during lung development, and that aberrant cell ..
  67. Hhex-a Homeobox Gene Necessary for Liver Development
    Clifford W Bogue; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Mice with a null mutation of the homeobox gene Hhex die mid-gestation with multiple developmental defects, including complete absence of the liver...
  68. Hex - a Homeobox Gene Essential for Liver Development
    CLIFFORD BOGUE; Fiscal Year: 2007
    Both we and others have shown that mice with a null mutation of the homeobox gene Hhex die mid-gestation with multiple developmental defects, including complete absence of the liver (REF)...