homeobox

Summary

Gene Symbol: homeobox
Description: ladybird homeobox 1
Alias: HPX-6, HPX6, LBX1H, homeobox, transcription factor LBX1, lady bird-like homeobox, ladybird homeobox homolog 1, ladybird homeobox protein homolog 1, transcription factor similar to D. melanogaster homeodomain protein lady bird late
Species: human
Products:     homeobox

Top Publications

  1. Jagla K, Dolle P, Mattei M, Jagla T, Schuhbaur B, Dretzen G, et al. Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. Mech Dev. 1995;53:345-56 pubmed
    We have cloned two novel homeobox genes which are the mouse (Lbx1) and human (LBX1) homologs of the Drosophila lady bird genes. They are highly related not only within the coding region but also in 5' and 3' untranslated regions...
  2. Holland P, Marlétaz F, Maeso I, Dunwell T, Paps J. New genes from old: asymmetric divergence of gene duplicates and the evolution of development. Philos Trans R Soc Lond B Biol Sci. 2017;372: pubmed
    ..We describe examples of asymmetric evolution in duplicated homeobox genes of moths, molluscs and mammals, in each case generating new homeobox genes that were recruited to novel ..
  3. Pan C, Gao H, Zheng N, Gao Q, Si Y, Zhao Y. MiR-320 inhibits the growth of glioma cells through downregulating PBX3. Biol Res. 2017;50:31 pubmed publisher
    ..PBX3 (Pre-B cell leukemia homeobox 3), a putative target gene of miR-320, has been reported to be upregulated in various tumors and promote tumor ..
  4. Yang J, Tian B, Sun H, Garofalo R, Brasier A. Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition. Nat Microbiol. 2017;2:17086 pubmed publisher
    ..Induced by the EMT, zinc finger E-box binding homeobox 1 (ZEB1) binds and silences IRF1...
  5. Busada J, Velte E, Serra N, Cook K, Niedenberger B, Willis W, et al. Rhox13 is required for a quantitatively normal first wave of spermatogenesis in mice. Reproduction. 2016;152:379-88 pubmed publisher
    We previously described a novel germ cell-specific X-linked reproductive homeobox gene (Rhox13) that is upregulated at the level of translation in response to retinoic acid (RA) in differentiating spermatogonia and preleptotene ..
  6. Ju H, Lee S, Lee J, Ghil S. Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1. Biochem Biophys Res Commun. 2017;489:109-115 pubmed publisher
    ..osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and distal-less Homeobox 5 (Dlx5) and Runx2 promoter activation...
  7. Saxena P, Bojar D, Zulewski H, Fussenegger M. Generation of glucose-sensitive insulin-secreting beta-like cells from human embryonic stem cells by incorporating a synthetic lineage-control network. J Biotechnol. 2017;259:39-45 pubmed publisher
    ..dynamics of the key transcription factors Ngn3 (neurogenin 3, OFF-ON-OFF), Pdx1 (pancreatic and duodenal homeobox 1, ON-OFF-ON) and MafA (V-maf musculoaponeurotic fibrosarcoma oncogene homologue A, OFF-ON) to guide the ..
  8. Chen C, Yan Q, Liu K, Zhou X, Xian Y, Liang D, et al. Endometrial Receptivity Markers in Mice Stimulated With Raloxifene Versus Clomiphene Citrate and Natural Cycles. Reprod Sci. 2016;23:748-55 pubmed publisher
    ..This study aimed to compare the expression of endometrial receptivity markers, including homeobox gene 10 (HOXA10), integrin β3, and leukemia inhibitory factor (LIF), as well as pinopode production during the ..
  9. Weiss E, Hanzelmann D, Fehlhaber B, Klos A, von Loewenich F, Liese J, et al. Formyl-peptide receptor 2 governs leukocyte influx in local Staphylococcus aureus infections. FASEB J. 2017;: pubmed publisher
    ..We characterized the specificity of mouse FPR2 (mFpr2) using a receptor-transfected cell line, homeobox b8 (Hoxb8), and primary neutrophils isolated from wild-type (WT) or mFpr2-/- mice...
  10. Swope D, Kramer J, King T, Cheng Y, Kramer S. Cdc42 is required in a genetically distinct subset of cardiac cells during Drosophila dorsal vessel closure. Dev Biol. 2014;392:221-32 pubmed publisher
    ..Disruption of Cdc42 function specifically prevents CBs that express the homeobox gene tinman from completing their dorsal migration, resulting in a failure to make connections with their ..

Detail Information

Publications62

  1. Jagla K, Dolle P, Mattei M, Jagla T, Schuhbaur B, Dretzen G, et al. Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. Mech Dev. 1995;53:345-56 pubmed
    We have cloned two novel homeobox genes which are the mouse (Lbx1) and human (LBX1) homologs of the Drosophila lady bird genes. They are highly related not only within the coding region but also in 5' and 3' untranslated regions...
  2. Holland P, Marlétaz F, Maeso I, Dunwell T, Paps J. New genes from old: asymmetric divergence of gene duplicates and the evolution of development. Philos Trans R Soc Lond B Biol Sci. 2017;372: pubmed
    ..We describe examples of asymmetric evolution in duplicated homeobox genes of moths, molluscs and mammals, in each case generating new homeobox genes that were recruited to novel ..
  3. Pan C, Gao H, Zheng N, Gao Q, Si Y, Zhao Y. MiR-320 inhibits the growth of glioma cells through downregulating PBX3. Biol Res. 2017;50:31 pubmed publisher
    ..PBX3 (Pre-B cell leukemia homeobox 3), a putative target gene of miR-320, has been reported to be upregulated in various tumors and promote tumor ..
  4. Yang J, Tian B, Sun H, Garofalo R, Brasier A. Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition. Nat Microbiol. 2017;2:17086 pubmed publisher
    ..Induced by the EMT, zinc finger E-box binding homeobox 1 (ZEB1) binds and silences IRF1...
  5. Busada J, Velte E, Serra N, Cook K, Niedenberger B, Willis W, et al. Rhox13 is required for a quantitatively normal first wave of spermatogenesis in mice. Reproduction. 2016;152:379-88 pubmed publisher
    We previously described a novel germ cell-specific X-linked reproductive homeobox gene (Rhox13) that is upregulated at the level of translation in response to retinoic acid (RA) in differentiating spermatogonia and preleptotene ..
  6. Ju H, Lee S, Lee J, Ghil S. Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1. Biochem Biophys Res Commun. 2017;489:109-115 pubmed publisher
    ..osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and distal-less Homeobox 5 (Dlx5) and Runx2 promoter activation...
  7. Saxena P, Bojar D, Zulewski H, Fussenegger M. Generation of glucose-sensitive insulin-secreting beta-like cells from human embryonic stem cells by incorporating a synthetic lineage-control network. J Biotechnol. 2017;259:39-45 pubmed publisher
    ..dynamics of the key transcription factors Ngn3 (neurogenin 3, OFF-ON-OFF), Pdx1 (pancreatic and duodenal homeobox 1, ON-OFF-ON) and MafA (V-maf musculoaponeurotic fibrosarcoma oncogene homologue A, OFF-ON) to guide the ..
  8. Chen C, Yan Q, Liu K, Zhou X, Xian Y, Liang D, et al. Endometrial Receptivity Markers in Mice Stimulated With Raloxifene Versus Clomiphene Citrate and Natural Cycles. Reprod Sci. 2016;23:748-55 pubmed publisher
    ..This study aimed to compare the expression of endometrial receptivity markers, including homeobox gene 10 (HOXA10), integrin β3, and leukemia inhibitory factor (LIF), as well as pinopode production during the ..
  9. Weiss E, Hanzelmann D, Fehlhaber B, Klos A, von Loewenich F, Liese J, et al. Formyl-peptide receptor 2 governs leukocyte influx in local Staphylococcus aureus infections. FASEB J. 2017;: pubmed publisher
    ..We characterized the specificity of mouse FPR2 (mFpr2) using a receptor-transfected cell line, homeobox b8 (Hoxb8), and primary neutrophils isolated from wild-type (WT) or mFpr2-/- mice...
  10. Swope D, Kramer J, King T, Cheng Y, Kramer S. Cdc42 is required in a genetically distinct subset of cardiac cells during Drosophila dorsal vessel closure. Dev Biol. 2014;392:221-32 pubmed publisher
    ..Disruption of Cdc42 function specifically prevents CBs that express the homeobox gene tinman from completing their dorsal migration, resulting in a failure to make connections with their ..
  11. Xu X, Cai N, Bao Z, You Y, Ji J, Liu N. Silencing Pre-B-cell leukemia homeobox 3 decreases the proliferation of human glioma cells in vitro and in vivo. J Neurooncol. 2017;135:453-463 pubmed publisher
    ..Pre-B-cell leukemia homeobox 3 (PBX3), a critical member of the PBX family, is frequently overexpressed in multiple human malignancies...
  12. Socorro M, Criscimanna A, Riva P, Tandon M, Prasadan K, Guo P, et al. Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas. Sci Rep. 2017;7:17539 pubmed publisher
    ..cells residing in the adult mouse pancreas have the ability to initiate Pancreatic and duodenal homeobox (Pdx1) expression for the first time...
  13. Li H, Li J, Yang T, Lin S, Li H. MicroRNA-433 Represses Proliferation and Invasion of Colon Cancer Cells by Targeting Homeobox A1. Oncol Res. 2017;: pubmed publisher
    ..b>Homeobox A1 (HOXA1) was identified as a target of miR-433 and it mediated the functions of miR-433 on colon cancer cell...
  14. Li X, Xu G, Zhai Z, Gao C, Yan H, Xi Q, et al. CDX2 increases SLC7A7 expression and proliferation of pig intestinal epithelial cells. Oncotarget. 2016;7:30597-609 pubmed publisher
    ..We evaluated the role of Caudal type homeobox 2 (CDX2), an intestine-specific transcription factor, in the proliferation of pig intestinal epithelial cells (..
  15. Smith A, Rohrer B, Wheless L, Samantaray S, Ray S, Inoue J, et al. Calpain inhibition reduces structural and functional impairment of retinal ganglion cells in experimental optic neuritis. J Neurochem. 2016;139:270-284 pubmed publisher
    ..calpain inhibitor SNJ 1945 preserves visual acuity and preserves retinal ganglion cells (Brn3a, brain-specific homeobox/POU domain protein 3A) and their axons (MOSP, myelin oligodendrocyte-specific protein)...
  16. Wang X, Chen S, Burtscher I, Sterr M, Hieronimus A, Machicao F, et al. Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene. Stem Cell Res. 2016;17:292-295 pubmed publisher
    Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor PDX1 leads to pancreatic agenesis, whereas certain heterozygous point mutations are associated with Maturity-Onset Diabetes of the Young 4 (..
  17. Nagel S, Pommerenke C, Meyer C, Kaufmann M, MacLeod R, Drexler H. NKL homeobox gene MSX1 acts like a tumor suppressor in NK-cell leukemia. Oncotarget. 2017;8:66815-66832 pubmed publisher
    NKL homeobox gene MSX1 is physiologically expressed in lymphoid progenitors and subsequently downregulated in developing T- and B-cells...
  18. Nguyen M, Singhal P, Piet J, Shefelbine S, Maden M, Voss S, et al. Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl. Development. 2017;144:601-611 pubmed publisher
    ..Transcriptomics identified expression patterns that explain PD duplication, including upregulation of proximal homeobox gene expression and silencing of distal-associated genes, whereas limb truncation was associated with disrupted ..
  19. Deng J, Dai T, Sun Y, Zhang Q, Jiang Z, Li S, et al. Overexpression of Prox1 Induces the Differentiation of Human Adipose-Derived Stem Cells into Lymphatic Endothelial-Like Cells In Vitro. Cell Reprogram. 2017;19:54-63 pubmed publisher
    Constant levels of homeobox transcription factor Prox1 expression are required throughout the life of lymphatic endothelial cells (LECs) to maintain their differentiated identity...
  20. Kan L, Thayer P, Fan H, Ledford B, Chen M, Goldstein A, et al. Polymer microfiber meshes facilitate cardiac differentiation of c-kit(+) human cardiac stem cells. Exp Cell Res. 2016;347:143-52 pubmed publisher
    ..The early (NK2 homeobox 5, Nkx2.5) and late (cardiac troponin I, cTnI) cardiomyocyte genes were significantly increased on meshes (Nkx=2...
  21. Widjaja Adhi M, Palczewski G, Dale K, Knauss E, Kelly M, Golczak M, et al. Transcription factor ISX mediates the cross talk between diet and immunity. Proc Natl Acad Sci U S A. 2017;114:11530-11535 pubmed publisher
    ..We report here that the intestine-specific homeobox protein ISX is critical to control the metabolic flow of β-carotene through this important branching point of ..
  22. Zeinali H, Baluchnejadmojarad T, Fallah S, Sedighi M, Moradi N, Roghani M. S-allyl cysteine improves clinical and neuropathological features of experimental autoimmune encephalomyelitis in C57BL/6 mice. Biomed Pharmacother. 2017;97:557-563 pubmed publisher
    ..cord tissue level of tumor necrosis factor α (TNFa), interleukin 17 (IL-17), activity-dependent neuroprotector homeobox (ADNP), microtubule-associated proteins 1A/1 B light chain 3A (MAP1LC3A), and matrix metalloproteinase 9 (MMP-9)..
  23. Mao L, Huang W, Zou P, Dang X, Zeng X. The unrecognized role of tumor suppressor genes in atrial fibrillation. Gene. 2017;: pubmed publisher
    ..of the unrecognized roles of tumor suppressor genes in the pathogenesis of atrial fibrillation, focusing mainly on the two well-characterized tumor suppressor genes, zinc finger homeobox protein-3 and esophageal cancer related gene-4.
  24. Brantley J, Sharma M, Alcalay N, Heuvel G. Cux-1 transgenic mice develop glomerulosclerosis and interstitial fibrosis. Kidney Int. 2003;63:1240-8 pubmed
    Cux-1 is a murine homeobox gene that is highly expressed in the nephrogenic zone of the developing kidney...
  25. Ruiz Estévez M, Bakkali M, Martín Blázquez R, Garrido Ramos M. Identification and Characterization of TALE Homeobox Genes in the Endangered Fern Vandenboschia speciosa. Genes (Basel). 2017;8: pubmed publisher
    ..reaction (qRT-PCR) analysis of the expression patterns of seven three amino acid loop extension (TALE) homeobox genes (four KNOTTED-like homeobox (KNOX) and three BEL1-like homeobox (BELL) genes) ..
  26. Hussien N, Ebrahim N, Mohammed O, Sabry D. Combination of Obestatin and Bone Marrow Mesenchymal Stem Cells Prevents Aggravation of Endocrine Pancreatic Damage in Type II Diabetic Rats. Int J Stem Cells. 2017;10:129-143 pubmed publisher
    ..Pancreatic expression of insulin, glucagon like peptide -1 (GLP-1) and pancreatic duodenal homeobox 1 (Pdx1) mRNA levels were measured...
  27. Xia H, Yan X, Liu Y, Ju P, Liu J, Ni D, et al. Six2 is involved in GATA1-mediated cell apoptosis in mouse embryonic kidney-derived cell lines. In Vitro Cell Dev Biol Anim. 2017;53:827-833 pubmed publisher
    Six2 (Sine oculis homeobox 2), a homeodomain transcription factor, plays a crucial role in the regulation of mammalian nephrogenesis...
  28. Simonova O. [A novel trans-regulatory locus in Drosophila]. Genetika. 2000;36:1464-74 pubmed
    ..alter expression of many loci, including the achaete and scute proneural genes and the cut locus coding for a homeobox-containing protein. A product of lawc is involved in regulating expression of white...
  29. Zhou L, Zhang X, Zhou P, Li X, Xu X, Shi Q, et al. Effect of testosterone and hypoxia on the expansion of umbilical cord blood CD34+ cells in vitro. Exp Ther Med. 2017;14:4467-4475 pubmed publisher
    ..The effects of oxygen concentration and testosterone on the expression of hematopoietic-related genes, including homeobox (HOX)A9, HOXB2, HOXB4, HOXC4 and BMI-1, were measured using reverse transcription-quantitative polymerase chain ..
  30. Cao Y, Min J, Zhang Q, Li H, Li H. Associations of LBX1 gene and adolescent idiopathic scoliosis susceptibility: a meta-analysis based on 34,626 subjects. BMC Musculoskelet Disord. 2016;17:309 pubmed publisher
    The results of studies investigating the association between the ladybird homeobox 1 (LBX1) gene polymorphisms and the risk of adolescent idiopathic scoliosis (AIS) are not all the same...
  31. Mathews C, Detmer K, Lawrence H, Largman C. Expression of the Hox 2.2 homeobox gene in murine embryonic epidermis. Differentiation. 1993;52:177-84 pubmed
    ..2 gene was studied in mouse fetal skin by in situ hybridization with an antisense RNA probe derived from the homeobox region of this gene. In contrast to the expression of Hox 2...
  32. Zaidi S, Gandhi J, Vatsia S, Smith N, Khan S. Congenital central hypoventilation syndrome: An overview of etiopathogenesis, associated pathologies, clinical presentation, and management. Auton Neurosci. 2017;: pubmed publisher
    ..The primary cause of CCHS is the mutation of the paired-like homeobox PHO2XB gene, found in 90% of the patients...
  33. Dhawan P, Veldurthy V, Yehia G, Hsaio C, Porta A, Kim K, et al. Transgenic Expression of the Vitamin D Receptor Restricted to the Ileum, Cecum, and Colon of Vitamin D Receptor Knockout Mice Rescues Vitamin D Receptor-Dependent Rickets. Endocrinology. 2017;158:3792-3804 pubmed publisher
    ..5-kb caudal type homeobox 2 promoter...
  34. Alharthi A, El Hallous E, Talaat I, Alghamdi H, Almalki M, Gaber A. Screening of SHOX gene sequence variants in Saudi Arabian children with idiopathic short stature. Korean J Pediatr. 2017;60:327-332 pubmed publisher
    ..Despite assumed genetic heterogeneity, mutations or deletions in the short stature homeobox-containing gene (SHOX) are frequently detected in subjects with short stature...
  35. Park S, Lee J, Kang M, Moon Y, Wang S, Kim K, et al. Potential of l-thyroxine to differentiate osteoblast-like cells via Angiopoietin1. Biochem Biophys Res Commun. 2016;478:1409-15 pubmed publisher
    ..and differentiation, such as type I collagen (COL1A1), osteocalcin (OC), bone sialoprotein (BSP), distal-less homeobox 5 (Dlx5), Runt-related transcription factor 2 (Runx2), osterix (OSX), and ALP, was tested by Western blotting ..
  36. Chen D, Sun Q, Zhang L, Zhou X, Cheng X, Zhou D, et al. The lncRNA HOXA11-AS functions as a competing endogenous RNA to regulate PADI2 expression by sponging miR-125a-5p in liver metastasis of colorectal cancer. Oncotarget. 2017;8:70642-70652 pubmed publisher
    ..We previously described the potential involvement of HOMEOBOX A11 (HOXA11) antisense RNA (HOXA11-AS), miR-125a-5p, and peptidyl arginine deiminase 2 (PADI2) in promoting liver ..
  37. Coelho C, Sumoy L, Kosher R, Upholt W. GHox-7: a chicken homeobox-containing gene expressed in a fashion consistent with a role in patterning events during embryonic chick limb development. Differentiation. 1992;49:85-92 pubmed
    b>Homeobox-containing (HOX) genes are thought to be involved in the regulation of pattern formation and specification of positional information during vertebrate limb development...
  38. Suh E, Wang Z, Swain G, Tenniswood M, Traber P. Clusterin gene transcription is activated by caudal-related homeobox genes in intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2001;280:G149-56 pubmed
    Caudal-related homeobox (Cdx) proteins play an important role in development and differentiation of the intestinal epithelium...
  39. Zhang H, Zheng F, Yang W, Lu J. The long non-coding RNA MIAT regulates zinc finger E-box binding homeobox 1 expression by sponging miR-150 and promoteing cell invasion in non-small-cell lung cancer. Gene. 2017;633:61-65 pubmed publisher
    ..Moreover, the knockdown of MIAT significantly downregulated the expression of the zinc finger E-box binding homeobox 1 (ZEB1), that was upregulated in NSCLC and that promoted cell invasion...
  40. Lopes D, Denk F, McMahon S. The Molecular Fingerprint of Dorsal Root and Trigeminal Ganglion Neurons. Front Mol Neurosci. 2017;10:304 pubmed publisher
    ..24 genes which were uniquely expressed in either ganglia, including an arginine vasopressin receptor and several homeobox genes, giving each population a distinct molecular fingerprint...
  41. Hong S, Kim D. Computational characterization of chromatin domain boundary-associated genomic elements. Nucleic Acids Res. 2017;45:10403-10414 pubmed publisher
    ..sites, H3K36 trimethylation, TSSs, RNA polymerase II, and TFs such as Specificity protein 1, ZNF274 and SIX homeobox 5...
  42. Ding K, Liu W, Zeng Q, Hou F, Xu J, Yang Z. Msx1-modulated muscle satellite cells retain a primitive state and exhibit an enhanced capacity for osteogenic differentiation. Exp Cell Res. 2017;352:84-94 pubmed publisher
    ..Muscle segment homeobox gene 1 (msx1) has been found to induce the dedifferentiation of committed progenitor cells, as well as terminally ..
  43. Sulkava M, Raitoharju E, Mennander A, Levula M, Seppälä I, Lyytikäinen L, et al. Differentially expressed genes and canonical pathways in the ascending thoracic aortic aneurysm - The Tampere Vascular Study. Sci Rep. 2017;7:12127 pubmed publisher
    ..The most downregulated gene was homeobox (HOX) A5 (fold change, FC = -25.3) and upregulated cadherin-2 (FC = 12.6)...
  44. Ni S, Ye M, Huang T. Short stature homeobox 2 methylation as a potential noninvasive biomarker in bronchial aspirates for lung cancer diagnosis. Oncotarget. 2017;8:61253-61263 pubmed publisher
    ..association domain family 1 isoform (RASSF1A), adenomatous polyposis coli (APC) and short stature homeobox 2 (SHOX2) genes was significantly correlated with lung cancer in bronchial aspirates...
  45. Xu X, Bao Z, Liu Y, Ji J, Liu N. MicroRNA-98 Attenuates Cell Migration and Invasion in Glioma by Directly Targeting Pre-B Cell Leukemia Homeobox 3. Cell Mol Neurobiol. 2017;37:1359-1371 pubmed publisher
    ..Subsequent investigation showed that pre-B-cell leukemia homeobox 3 (PBX3), an important transcription factor that controls tumor invasion, was a direct and functional target of ..
  46. Alvarez J, Furumizu C, Efroni I, Eshed Y, Bowman J. Active suppression of a leaf meristem orchestrates determinate leaf growth. elife. 2016;5: pubmed publisher
    ..meristem to the margins is mediated by the juxtaposition of adaxial and abaxial domains and maintained by WOX homeobox transcription factors, whereas other marginal elaboration genes are dispensable for its maintenance...
  47. Kim C, Nielsen H. Hoxa-5 in mouse developing lung: cell-specific expression and retinoic acid regulation. Am J Physiol Lung Cell Mol Physiol. 2000;279:L863-71 pubmed
    Hoxa-5 is a homeobox gene that is highly expressed in the developing mouse lung. However, little is known about the molecular mechanisms controlling expression...
  48. Tucker M, Sieber M, Morphew M, Han M. The Caenorhabditis elegans aristaless orthologue, alr-1, is required for maintaining the functional and structural integrity of the amphid sensory organs. Mol Biol Cell. 2005;16:4695-704 pubmed
    The homeobox-containing aristaless-related protein ARX has been directly linked to the development of a number of human disorders involving mental retardation and epilepsy and clearly plays a critical role in development of the vertebrate ..
  49. Le T, Zhou Q, Cobos I, Zhang S, Zagozewski J, Japoni S, et al. GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by Dlx Homeobox Transcription Factors. J Neurosci. 2017;37:8816-8829 pubmed publisher
    ..In the telencephalon, members of the distal-less (Dlx) homeobox gene family are expressed in, and regulate the development of, the basal ganglia primodia from which many ..
  50. Jouhilahti E, Madissoon E, Vesterlund L, Tohonen V, Krjutskov K, Plaza Reyes A, et al. The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation. Development. 2016;143:3459-3469 pubmed
    Leucine twenty homeobox (LEUTX) is a paired (PRD)-like homeobox gene that is expressed almost exclusively in human embryos during preimplantation development...
  51. Ramberg H, Grytli H, Nygard S, Wang W, Ogren O, Zhao S, et al. PBX3 is a putative biomarker of aggressive prostate cancer. Int J Cancer. 2016;139:1810-20 pubmed publisher
    ..The aims of this study were to characterize the expression profile of pre-B cell leukemia homeobox (PBX) transcription factors in prostate cancer with an emphasis on investigating whether PBX3 harbours any ..
  52. Singh M, Gupta A, Singh D, Khurana J, Laxmi A. Arabidopsis RSS1 Mediates Cross-Talk Between Glucose and Light Signaling During Hypocotyl Elongation Growth. Sci Rep. 2017;7:16101 pubmed publisher
    ..their downstream targets such as YUCs, INDOLE-3-ACETIC ACID INDUCIBLE (IAAs), LONG HYPOCOTYL IN FAR-RED1 (HFR1), HOMEOBOX PROTEIN 2 (ATHB2), XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASES (XTHs) and EXPANSINS...
  53. Ruzycki P, Linne C, Hennig A, Chen S. Crx-L253X Mutation Produces Dominant Photoreceptor Defects in TVRM65 Mice. Invest Ophthalmol Vis Sci. 2017;58:4644-4653 pubmed publisher
    The cone-rod homeobox (CRX) transcription factor is essential for photoreceptor gene expression, differentiation, and survival. Human CRX mutations can cause dominant retinopathies of varying onset and phenotype severity...
  54. Kim D, Kim E, Jang W. Piperine induces osteoblast differentiation through AMPK-dependent Runx2 expression. Biochem Biophys Res Commun. 2017;: pubmed publisher
    ..Piperine-induced expression of the osteogenic genes such as distal-less homeobox 5 (Dlx5), inhibitor of DNA binding-1 (Id1), and runt-related transcription factor 2 (Runx2) was investigated ..
  55. Yang L, Li C, Liang F, Fan Y, Zhang S. MiRNA-155 promotes proliferation by targeting caudal-type homeobox 1 (CDX1) in glioma cells. Biomed Pharmacother. 2017;95:1759-1764 pubmed publisher
    ..In the present study, expression of miR-155 and caudal-type homeobox 1 (CDX1) was determined in glioma tissues by qRT-PCR, and the regulatory axis was further studied in glioma cells...
  56. Sakurai N, Takahashi K, Emura N, Fujii T, Hirayama H, Kageyama S, et al. The Necessity of OCT-4 and CDX2 for Early Development and Gene Expression Involved in Differentiation of Inner Cell Mass and Trophectoderm Lineages in Bovine Embryos. Cell Reprogram. 2016;18:309-318 pubmed
    The functions of POU class 5 transcription factor 1 (Oct-4) and caudal-type homeobox 2 (Cdx2) in the differentiation of the murine inner cell mass (ICM) and trophectoderm (TE) have been described in detail...