HPR

Summary

Gene Symbol: HPR
Description: haptoglobin-related protein
Alias: A-259H10.2, haptoglobin-related protein, Haptoglobin-related locus
Species: human

Top Publications

  1. ncbi Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II
    Carla G Monico
    Division of Nephrology, General Clinical Research Center, Mayo Clinic Rochester, Minnesota 55905, USA
    Kidney Int 62:392-400. 2002
  2. pmc Sinorhizobium meliloti mutants lacking phosphotransferase system enzyme HPr or EIIA are altered in diverse processes, including carbon metabolism, cobalt requirements, and succinoglycan production
    Catalina Arango Pinedo
    Department of Molecular and Cell Biology, University of Connecticut, 91 N Eagleville Rd, U 3125, Storrs, CT 06269 3125, USA
    J Bacteriol 190:2947-56. 2008
  3. ncbi Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element
    N Maeda
    J Biol Chem 260:6698-709. 1985
  4. ncbi Killing of trypanosomes by the human haptoglobin-related protein
    A B Smith
    Department of Biochemistry and Molecular Genetics, School of Medicine and Dentistry, University of Alabama at Birmingham 35294, USA
    Science 268:284-6. 1995
  5. pmc Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Proc Natl Acad Sci U S A 104:4118-23. 2007
  6. ncbi Characterization of the human serum trypanosome toxin, haptoglobin-related protein
    M Muranjan
    New York University Medical Center, Department of Pathology, New York, New York 10016, USA
    J Biol Chem 273:3884-7. 1998
  7. ncbi Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein
    Marianne Jensby Nielsen
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    Blood 108:2846-9. 2006
  8. ncbi Catabolite repression and inducer control in Gram-positive bacteria
    M H Saier
    Department of Biology, University of California at San Diego, La Jolla 92093 0116, USA
    Microbiology 142:217-30. 1996
  9. ncbi Cancer risk factors for selecting cohorts for large-scale chemoprevention trials
    P Greenwald
    Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biochem Suppl 25:29-36. 1996
  10. ncbi Distribution of free amino acids in streptozotocin-induced diabetic pregnant rats, their placentae and fetuses
    A D Copeland
    Department of Physiology and Endocrinology, Medical College of Georgia, Augusta
    Horm Metab Res 22:65-70. 1990

Detail Information

Publications316 found, 100 shown here

  1. ncbi Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II
    Carla G Monico
    Division of Nephrology, General Clinical Research Center, Mayo Clinic Rochester, Minnesota 55905, USA
    Kidney Int 62:392-400. 2002
    ..Hepatic alanine:glyoxylate aminotransferase (AGT) or glyoxylate/hydroxypyruvate reductase (GR/HPR) deficiency causes PHI or PHII, respectively...
  2. pmc Sinorhizobium meliloti mutants lacking phosphotransferase system enzyme HPr or EIIA are altered in diverse processes, including carbon metabolism, cobalt requirements, and succinoglycan production
    Catalina Arango Pinedo
    Department of Molecular and Cell Biology, University of Connecticut, 91 N Eagleville Rd, U 3125, Storrs, CT 06269 3125, USA
    J Bacteriol 190:2947-56. 2008
    ..meliloti. The genes present code for Hpr and ManX (an EIIA(Man)-type enzyme). HPr and EIIA regulate carbon utilization in other bacteria...
  3. ncbi Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element
    N Maeda
    J Biol Chem 260:6698-709. 1985
    Thirty-three kilobase pairs (kb) of human DNA containing the haptoglobin (Hp) and haptoglobin-related (Hpr) gene pair were cloned, and the nucleotide sequence of 21-kb DNA was determined...
  4. ncbi Killing of trypanosomes by the human haptoglobin-related protein
    A B Smith
    Department of Biochemistry and Molecular Genetics, School of Medicine and Dentistry, University of Alabama at Birmingham 35294, USA
    Science 268:284-6. 1995
    ..An antibody to haptoglobin inhibited TLF activity. TLF was shown to exhibit peroxidase activity and to be inhibited by catalase. These results suggest that TLF kills trypanosomes by oxidative damage initiated by its peroxidase activity...
  5. pmc Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Proc Natl Acad Sci U S A 104:4118-23. 2007
    ..Another HDL component, haptoglobin-related protein (Hpr), has been suggested as an additional toxin required for full trypanolytic activity of normal human serum...
  6. ncbi Characterization of the human serum trypanosome toxin, haptoglobin-related protein
    M Muranjan
    New York University Medical Center, Department of Pathology, New York, New York 10016, USA
    J Biol Chem 273:3884-7. 1998
    Haptoglobin-related protein (HPR) is a serum protein that is >90% homologous to the acute-phase reactant haptoglobin (Hp). Haptoglobin binds and removes free hemoglobin (Hb) from the circulation...
  7. ncbi Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein
    Marianne Jensby Nielsen
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
    Blood 108:2846-9. 2006
    Haptoglobin-related protein (Hpr) is a primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL) particles shown to be a part of the innate immune defense...
  8. ncbi Catabolite repression and inducer control in Gram-positive bacteria
    M H Saier
    Department of Biology, University of California at San Diego, La Jolla 92093 0116, USA
    Microbiology 142:217-30. 1996
    ..available clearly indicate that the metabolite-activated protein kinase-mediated phosphorylation of Ser-46 in HPr plays a key role in catabolite repression and the control of inducer levels in low-GC Gram-positive bacteria...
  9. ncbi Cancer risk factors for selecting cohorts for large-scale chemoprevention trials
    P Greenwald
    Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biochem Suppl 25:29-36. 1996
    ..Trial (tamoxifen), the Prostate Cancer Prevention Trial (finasteride), and the N-(4-hydroxyphenyl) retinamide (4-HPR) breast cancer prevention study being conducted in Milan...
  10. ncbi Distribution of free amino acids in streptozotocin-induced diabetic pregnant rats, their placentae and fetuses
    A D Copeland
    Department of Physiology and Endocrinology, Medical College of Georgia, Augusta
    Horm Metab Res 22:65-70. 1990
    ..Placental levels of Tau, Gln, HPr, Thr and Lys were depressed in the diabetic animals and insulin treatment only partially improved these amino acid ..
  11. pmc Loss of protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system, by mutation of the ptsH gene confers catabolite repression resistance to several catabolic genes of Bacillus subtilis
    J Deutscher
    Max Planck Institute for Molecular Physiology, Dortmund, Germany
    J Bacteriol 176:3336-44. 1994
    In gram-positive bacteria, HPr, a phosphocarrier protein of the phosphoenolpyruvate:sugar phosphotransferase system (PTS), is phosphorylated by an ATP-dependent, metabolite-activated protein kinase on seryl residue 46...
  12. ncbi Acute hyperleptinemia does not modify insulin sensitivity in vivo in the rat
    P S Widdowson
    Department of Medicine, Liverpool University, UK
    Horm Metab Res 30:259-62. 1998
    ..clamping were not different between leptin-infused and control rats, and there were no significant effects on the HPR or WBU measured using [6-(3)H]glucose under basal or clamped conditions...
  13. ncbi Chemoprevention of breast cancer
    M P Osborne
    Department of Surgery, Cornell University Medical College, New York, New York, USA
    Surg Clin North Am 79:1207-21. 1999
    ..Based on experimental studies, the vitamin A analogue 4-hydroxyphenyl retinamide (4-HPR) was shown to delay and reduce carcinogen-induced breast cancer...
  14. ncbi Inhibition of the phosphoenolpyruvate:lactose phosphotransferase system and activation of a cytoplasmic sugar-phosphate phosphatase in Lactococcus lactis by ATP-dependent metabolite-activated phosphorylation of serine 46 in the phosphocarrier protein HPr
    J J Ye
    Department of Biology, University of California at San Diego, La Jolla 92093 0116
    J Biol Chem 269:11837-44. 1994
    ..Intravesicular (but not extravesicular) wild-type HPr of Bacillus subtilis completely restored the regulatory behavior observed in vivo when glucose was present in the ..
  15. ncbi Executive Summary of the National Cancer Institute Workshop: Highlights and recommendations
    R Lieberman
    National Cancer Institute, Rockville, Maryland, USA
    Urology 57:4-27. 2001
    ..research program and began testing the first generation of promising agents (eg, 4-(hydroxy)-fenretinide [4-HPR], difluoromethylornithine [DFMO], antiandrogens) in high-risk cohorts and launched the first-large scale US phase 3 ..
  16. ncbi Ligand-activated progesterone receptor isoform hPR-A is a stronger transactivator than hPR-B for the expression of IGFBP-1 (insulin-like growth factor binding protein-1) in human endometrial stromal cells
    J Gao
    Department of Obstetrics Gynecology and Reproductive Medicine, School of Medicine, State University of New York at Stony Brook, 11794, USA
    Mol Endocrinol 14:1954-61. 2000
    In human endometrium, the levels of progesterone receptor (PR) isoforms hPR-A and hPR-B are differentially regulated during the reproductive cycle...
  17. ncbi [Chronic dizziness in elderly people: its clinical characteristics and magneto-encephalographic findings]
    Hiroaki Naritomi
    Department of Cerebrovascular Medicine, National Cardiovascular Center
    Rinsho Shinkeigaku 48:393-400. 2008
    ..can be hypothecated on the basis of MEG findings as follows: Presumably, there are head-position recognizing (HPR) centers in the left and right cerebral hemispheres...
  18. ncbi Catabolite repression of dra-nupC-pdp operon expression in Bacillus subtilis
    X Zeng
    Department of Microbiology, Technical University of Denmark, Building 301, DK 2800 Lyngby, Denmark
    Microbiology 146:2901-8. 2000
    ..repression of dra-nupC-pdp expression was relieved in a ccpA mutant and was found to be dependent on both HPr and the HPr-like protein Crh...
  19. ncbi Functional interactions between proteins of the phosphoenolpyruvate:sugar phosphotransferase systems of Bacillus subtilis and Escherichia coli
    J Reizer
    Department of Biology, University of California at San Diego, La Jolla 92093 0116
    J Biol Chem 267:9158-69. 1992
    ..The proteins isolated include Enzyme I, HPr, the glucose-specific IIA domain of the glucose-specific Enzyme II (IIAglc), and the mannitol-specific IIA protein, ..
  20. doi Mutual self-defence: the trypanolytic factor story
    Etienne Pays
    Laboratory of Molecular Parasitology, Universite Libre de Bruxelles, Gosselies, Belgium
    Microbes Infect 10:985-9. 2008
    ..binds to a subset of HDL particles that also contain another human-specific protein, haptoglobin-related protein or Hpr. T. b...
  21. ncbi Chemoprevention of breast cancer with fenretinide (4-HPR): study of long-term visual and ophthalmologic tolerability
    L Mariani
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 82:444-9. 1996
    BACKGROUND: Fenretinide (4-HPR) is a synthetic retinoid being clinically tested in the chemoprevention of different tumors and precancerous lesions...
  22. ncbi The significance of the 20-carbonyl group of progesterone in steroid receptor binding: a molecular dynamics and structure-based ligand design study
    Alexander Hillisch
    EnTec GmbH, Adolf Reichwein Str 20, D 07745 Jena, Germany
    Steroids 68:869-78. 2003
    ..Also site-directed mutagenesis studies of the human progesterone receptor (hPR) suggest an important role for Cys891 in the recognition of the progesterone 20-carbonyl group...
  23. ncbi Chemoprevention trial of contralateral breast cancer with fenretinide. Rationale, design, methodology, organization, data management, statistics and accrual
    G De Palo
    Istituto Nazionale Tumori, University of Milan, Italy
    Tumori 83:884-94. 1997
    The Fenretinide (4-HPR) Breast Cancer Study is a randomized multicenter clinical trial originally designed and conducted by the investigators of the Istituto Nazionale Tumori of Milan...
  24. pmc Modulation of Escherichia coli adenylyl cyclase activity by catalytic-site mutants of protein IIA(Glc) of the phosphoenolpyruvate:sugar phosphotransferase system
    P Reddy
    Biotechnology Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 0001, USA
    J Bacteriol 180:732-6. 1998
    ..75 has been replaced by glutamine, were phosphorylated by the phosphohistidine-containing phosphocarrier protein (HPr-P) and were equally potent activators of adenylyl cyclase...
  25. ncbi Structural consequences of histidine phosphorylation: NMR characterization of the phosphohistidine form of histidine-containing protein from Bacillus subtilis and Escherichia coli
    P Rajagopal
    Department of Biochemistry, University of Washington, Seattle 98195
    Biochemistry 33:15271-82. 1994
    ..Histidine-containing protein (HPr) is phosphorylated on the N delta 1 position of the imidazole ring of His15 by enzyme I and acts as a phosphoryl ..
  26. ncbi Identification by NMR of the binding surface for the histidine-containing phosphocarrier protein HPr on the N-terminal domain of enzyme I of the Escherichia coli phosphotransferase system
    D S Garrett
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
    Biochemistry 36:4393-8. 1997
    ..5 kDa histidine-containing phosphocarrier protein HPr of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system has been investigated by heteronuclear ..
  27. ncbi In vitro effects of fenretinide on cell-matrix interactions
    M Vaccari
    Istituto Nazionale per la Ricerca sul Cancro, Genova Biotechnology Satellite Unit, Bologna, Italy
    Anticancer Res 20:3059-66. 2000
    ..Fenretinide (4-HPR), a synthetic derivative of retinoic acid, is less toxic than natural retinoids and is active in the prevention and ..
  28. ncbi Inhibition of neuroblastoma-induced angiogenesis by fenretinide
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Int J Cancer 94:314-21. 2001
    ..The synthetic retinoid fenretinide (HPR) inhibits carcinogenesis in various animal models...
  29. ncbi Pineal gland abnormalities in Langerhans cell histiocytosis
    N Grois
    Children s Cancer Research Institute, St Anna Children s Hospital, Vienna, Austria
    Pediatr Blood Cancer 43:261-6. 2004
    ..CNS) disease in Langerhans cell histiocytosis (LCH) comprise involvement of the hypothalamic-pituitary region (HPR) and neurodegenerative changes in the cerebellum, basal ganglia or pons...
  30. ncbi Accrual issues for chemoprevention trials: the example of the 4-HPR study for the prevention of contralateral breast cancer
    T Camerini
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 85:299-303. 1999
    ..The known accrual difficulties of chemoprevention studies proved also to be true for the high-risk population of this trial...
  31. ncbi High affinity binding and allosteric regulation of Escherichia coli glycogen phosphorylase by the histidine phosphocarrier protein, HPr
    Y J Seok
    NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:26511-21. 1997
    The histidine phosphocarrier protein (HPr) is an essential element in sugar transport by the bacterial phosphoenolpyruvate:sugar phosphotransferase system...
  32. ncbi Fenretinide breast cancer prevention trial: drug and retinol plasma levels in relation to age and disease outcome
    Franca Formelli
    Istituto Nazionale Tumori, 20133 Milan, Italy
    Cancer Epidemiol Biomarkers Prev 12:34-41. 2003
    To assess, in women participating in a breast cancer prevention trialon fenretinide (4-HPR), the relationship of drug and retinol levels with the risk of second breast malignancy, taking into account age and menopausal status.
  33. ncbi Expression of the progesterone receptor and progesterone- metabolising enzymes in the female and male human kidney
    C Bumke-Vogt
    Department of Endocrinology, Klinikum Benjamin Franklin, Freie Universitat Berlin, Germany
    J Endocrinol 175:349-64. 2002
    ..As a prerequisite for sequestration of progesterone by binding to the human progesterone receptor (hPR) we demonstrated the existence of hPR expression in female and male kidney cortex and medulla at the level of ..
  34. ncbi Structure of the IIA domain of the glucose permease of Bacillus subtilis at 2.2-A resolution
    D I Liao
    Center for Advanced Research in Biotechnology, Maryland Biotechnology Institute, Rockville 20850
    Biochemistry 30:9583-94. 1991
    ..His83, the histidyl residue which is the phosphorylation target of HPr and which transfers the phosphoryl group to the IIB domain of the permease, is located at the C-terminus of a beta-..
  35. ncbi Protein kinase-dependent HPr/CcpA interaction links glycolytic activity to carbon catabolite repression in gram-positive bacteria
    J Deutscher
    , CNRS, Lyon, France
    Mol Microbiol 15:1049-53. 1995
    ..CcpA-his immobilized on a Ni-NTA resin specifically interacted with HPr phosphorylated at seryl residue 46...
  36. ncbi African trypanosomes: intracellular trafficking of host defense molecules
    April M Shiflett
    Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    J Eukaryot Microbiol 54:18-21. 2007
    ..HDL), containing apolipoprotein A-I (APOA1), apolipoprotein L-I (APOL1) and haptoglobin-related protein (HPR) provides this innate protection against T. b. brucei infection. Both HPR and APOL1 are cytotoxic to T. b...
  37. ncbi Hyperintense putaminal rim at 3T reflects fewer ferritin deposits in the lateral marginal area of the putamen
    S Fujii
    Division of Radiology, Department of Pathophysiological and Therapeutic Science, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
    AJNR Am J Neuroradiol 28:777-81. 2007
    The aim of this study was to clarify the cause of hyperintense putaminal rim (HPR) on the basis of 3T MR imaging-pathologic correlations.
  38. ncbi Characterization of infectious bursal disease viruses from four layer flocks in the United States
    B Sreedevi
    Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
    Avian Dis 51:845-50. 2007
    ..The sequence of HPR-2 was similar to the Bursa Vac 4 vaccine used in that flock and the STC virulent classic IBDV strain...
  39. pmc Molecular characterization of the Lactococcus lactis ptsHI operon and analysis of the regulatory role of HPr
    E J Luesink
    Microbial Ingredients Section, NIZO Food Research, 6710 BA Ede, The Netherlands
    J Bacteriol 181:764-71. 1999
    ..ptsH and ptsI genes, encoding the general proteins of the phosphoenolpyruvate-dependent phosphotransferase system, HPr and enzyme I, respectively, were cloned, and the regulatory role of HPr was studied by mutational analysis of its ..
  40. ncbi Effects of retinoids on proliferation and plasminogen activator expression in a bovine mammary epithelial cell line
    Federica Cheli
    Department of Veterinary Science and Technology for Food Safety, University of Milan, Milan, Italy 20134
    J Dairy Res 70:367-72. 2003
    Effects of two natural (retinol and retinoic acid, RA) and one synthetic N-(4-hydroxyphenyl) retinamide (4-HPR) retinoids on proliferation and expression of urokinase-plasminogen activator (u-PA) by bovine mammary epithelial cells were ..
  41. ncbi High-resolution structure of the phosphorylated form of the histidine-containing phosphocarrier protein HPr from Escherichia coli determined by restrained molecular dynamics from NMR-NOE data
    N A Van Nuland
    Groningen Biomolecular Sciences and Biotechnology Institute, The Netherlands
    J Mol Biol 246:180-93. 1995
    The solution structure of the phosphorylated form of the histidine-containing phosphocarrier protein, HPr, from Escherichia coli has been determined by NMR in combination with restrained molecular dynamics simulations...
  42. ncbi Structural studies of histidine-containing phosphocarrier protein from Enterococcus faecalis
    M Hahmann
    Max Planck Institute for Medical Research, Dept Biophysics, Heidelberg, Germany
    Eur J Biochem 252:51-8. 1998
    ..the secondary structure and the local geometry of the active site of histidine-containing phosphocarrier protein (HPr) from Enterococcus faecalis were elucidated...
  43. ncbi The phosphotransferase system (PTS) of Streptomyces coelicolor identification and biochemical analysis of a histidine phosphocarrier protein HPr encoded by the gene ptsH
    S Parche
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Eur J Biochem 265:308-17. 1999
    b>HPr, the histidine-containing phosphocarrier protein of the bacterial phosphotransferase system (PTS) controls sugar uptake and carbon utilization in low-GC Gram-positive bacteria and in Gram-negative bacteria...
  44. ncbi Quality control for HPLC assay and surrogate end point biomarkers from the fenretinide (4-HPR) breast cancer prevention trial
    F Formelli
    Istituto Nazionale Tumori, Milan, Italy
    J Cell Biochem Suppl 34:73-9. 2000
    The Fenretinide (4-HPR) Breast Cancer Study is a randomized multicenter clinical trial designed to evaluate the effectiveness of the synthetic retinoid 4-HPR, at a dose of 200 mg per os every day for 5 years, in reducing the incidence of ..
  45. ncbi The 1.9 A resolution structure of phospho-serine 46 HPr from Enterococcus faecalis
    G F Audette
    Department of Biochemistry, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5, Canada
    J Mol Biol 303:545-53. 2000
    The histidine-containing phosphocarrier protein HPr is a central component of the phosphoenolpyruvate:sugar phosphotransferase system (PTS), which transfers metabolic carbohydrates across the cell membrane in many bacterial species...
  46. ncbi Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants
    D Gaur
    Immunochemistry Laboratory, National Institute of Immunology, Aruna Asaf Ali Road, New Delhi 110067, India
    J Biol Chem 276:24978-84. 2001
    ..Human pancreatic ribonuclease (HPR) is structurally and functionally very similar to bovine RNase A and interacts with human RI with a high affinity...
  47. pmc Loss of catabolite repression function of HPr, the phosphocarrier protein of the bacterial phosphotransferase system, affects expression of the cry4A toxin gene in Bacillus thuringiensis subsp. israelensis
    Sharik R Khan
    Centre for Biotechnology, Jawaharlal Nehru University International Centre For Genetic Engineering and Biotechnology, New Delhi, India
    J Bacteriol 184:5410-7. 2002
    b>HPr, the phosphocarrier protein of the bacterial phosphotransferase system, mediates catabolite repression of a number of operons in gram-positive bacteria...
  48. pmc Regulatory functions of serine-46-phosphorylated HPr in Lactococcus lactis
    V Monedero
    Laboratoire de génétique des microorganismes, INRA CNRS URA 1925, 78850 Thiverval Grignon, France
    J Bacteriol 183:3391-8. 2001
    In most low-G+C gram-positive bacteria, the phosphoryl carrier protein HPr of the phosphoenolpyruvate:sugar phosphotransferase system (PTS) becomes phosphorylated at Ser-46...
  49. ncbi p-Dodecylaminophenol derived from the synthetic retinoid, fenretinide: antitumor efficacy in vitro and in vivo against human prostate cancer and mechanism of action
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Int J Cancer 122:689-98. 2008
    Fenretinide, N-(4-hydroxyphenyl)retinamide (4-HPR) is an aminophenol-containing synthetic retinoid derivative of all-trans-retinoic acid, which is a potent chemopreventive and antiproliferative agent against various cancers...
  50. ncbi Psychologic aspects of patients participating in a phase I study with the synthetic retinoid 4-hydroxyphenyl retinamide
    A Filiberti
    Terapia del Dolore, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano
    Tumori 74:353-6. 1988
    One hundred and one patients participating in a phase I study with the synthetic retinoid 4-HPR (4-hydroxyphenyl retinamide) were evaluated. The study was set up by Veronesi et al. during 1986 at the National Cancer Institute of Milan...
  51. ncbi Expression of a single gene encoding microbody NAD-malate dehydrogenase during glyoxysome and peroxisome development in cucumber
    D J Kim
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Plant Mol Biol 26:1833-41. 1994
    ..but then MDH mRNA increases again together with that of peroxisomal NAD(+)-dependent hydroxypyruvate reductase (HPR). The mdh gene is also expressed during cotyledon senescence, together with hpr, icl and ms genes...
  52. pmc Regulation of the glucose:H+ symporter by metabolite-activated ATP-dependent phosphorylation of HPr in Lactobacillus brevis
    J J Ye
    Department of Biology, University of California at San Diego, La Jolla 92093 0116
    J Bacteriol 176:3484-92. 1994
    ..regulation was shown to be mediated by a metabolite-activated protein kinase that phosphorylase serine 46 in the HPr protein. We have now analyzed the regulation of 2DG uptake and efflux and compared it with that of TMG...
  53. ncbi Identification of methionine-processed HPr in the equine pathogen Streptococcus equi
    I C Sutcliffe
    School of Sciences, University of Sunderland, UK
    Syst Appl Microbiol 23:330-2. 2000
    ..equi. N-terminal sequence analysis and Western blotting revealed the protein to be HPr, a central component of the phosphoenolpyruvate:sugar phosphotransferase system (PTS)...
  54. ncbi Bayesian monitoring of a phase 2 chemoprevention trial in high-risk cohorts for prostate cancer
    H L Weiss
    Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
    Urology 57:220-3. 2001
    ..A phase 2 chemoprevention trial of 4-hydroxyphenyl retinamide (4-HPR) versus placebo was conducted in men with a histologic diagnosis of early prostate cancer and scheduled to have ..
  55. ncbi Characterization of glucose-repression-resistant mutants of Bacillus subtilis: identification of the glcR gene
    J Stülke
    Unité de Biochimie Microbienne, Institut Pasteur, Paris, France
    Arch Microbiol 175:441-9. 2001
    ..repression (CCR) is mediated by the pleiotropic repressor CcpA and by ATP-dependent phosphorylation of the HPr protein of the phosphotransferase system (PTS)...
  56. ncbi A novel mode of control of Mycoplasma pneumoniae HPr kinase/phosphatase activity reflects its parasitic lifestyle
    Katrin Steinhauer
    Lehrstuhl fur Mikrobiologie, Institut fur Mikrobiologie, Biochemie und Genetik der Friedrich Alexander Universität Erlangen Nürnberg, Staudtstr 5, Germany
    Microbiology 148:3277-84. 2002
    Among the few regulatory proteins encoded by Mycoplasma pneumoniae is HPr kinase/phosphatase (HPrK/P), the key regulator of carbon metabolism in low-GC Gram-positive bacteria...
  57. ncbi Chemopreventive agents induce a senescence-like phenotype in rat mammary tumours
    K T Christov
    Department of Surgical Oncology, University of Illinois, 840 South Wood Street, Chicago, IL 60612, USA
    Eur J Cancer 39:230-9. 2003
    ..MNU)-induced mammary tumours were randomised and treated with tamoxifen, vorozole, 4-(hydroxyphenyl)retinamide (4-HPR), or 9-cis-retinoic acid (9cRA)...
  58. ncbi Biomedical engineering analysis of glass impact injuries
    Anthony Sances
    Biomechanics Institute Santa Barbara, California 93109, USA
    Crit Rev Biomed Eng 30:345-77. 2002
    ..The development, use, and results of high penetration resistance (HPR) laminated glass for windshields are examined...
  59. ncbi An intronic endogenous retrovirus-like sequence attenuates human haptoglobin-related gene expression in an orientation-dependent manner
    Seigo Hatada
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Gene 319:55-63. 2003
    The human haptoglobin-related gene (HPR) gene codes for a haptoglobin-related protein (Hpr), a component of trypanosome lytic factor which circulates in plasma in small quantities...
  60. ncbi Characterization of primate trypanosome lytic factors
    Elena B Lugli
    Department of Medical and Molecular Parasitology, New York University School of Medicine, 341, East 25th Street, New York, NY 10010, USA
    Mol Biochem Parasitol 138:9-20. 2004
    ..Haptoglobin-related protein (Hpr) is a unique protein component of TLFs, and its expression has only been demonstrated in humans...
  61. doi Streptococci and lactococci synthesize large amounts of HPr(Ser-P)(His~P)
    Denis J Roy
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, 2420 Rue de la Terrasse, Quebec City, QC G1V0A6, Canada
    Can J Microbiol 54:941-9. 2008
    b>HPr is a protein of the phosphoenolpyruvate:sugar phosphotransferase transport system (PTS)...
  62. doi Protein structure calculation with data imputation: the use of substitute restraints
    Carolina Cano
    Institut fur Biophysik und Physikalische Biochemie, University of Regensburg, Universitätstr Regensburg, Germany
    J Biomol NMR 45:397-411. 2009
    ..tested on three examples: firstly, the Ras-binding domain of Byr2 from Schizosaccharomyces pombe, the mutant HPr (H15A) from Staphylococcus aureus, and a X-ray structure of human ubiquitin...
  63. doi The anti-tumor agent, p-DDAP potently suppresses proliferation through apoptosis in human neuroblastoma NB-39-nu cells
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Cancer Lett 297:252-8. 2010
    ..NB-39-nu cells of p-dodecylaminophenol (p-DDAP), a novel derivative of N-(4-hydroxyphenyl) retinamide (4-HPR). p-DDAP suppresses proliferation, and induces G(0)/G(1) arrest and apoptosis to a greater extent than RA and 4-HPR...
  64. doi Stability of the high on-treatment platelet reactivity phenotype over time in clopidogrel-treated patients
    Juliane Jaitner
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munchen, Munich, Germany
    Thromb Haemost 105:107-12. 2011
    ..In recent studies and ongoing large-scale trials where patients with high on-treatment platelet reactivity (HPR) to clopidogrel are being randomised to an intensified antiplatelet treatment, confirmation of the HPR phenotype is ..
  65. doi HOXC8 inhibits androgen receptor signaling in human prostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes
    Sunshine Daddario Axlund
    Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, 12801 E 17th Ave, Aurora, CO 80045, USA
    Mol Cancer Res 8:1643-55. 2010
    ..we show that HOXC8 inhibits androgen receptor (AR)-mediated gene induction in LNCaP prostate cancer cells and HPr-1 AR, a nontumorigenic prostate epithelial cell line...
  66. pmc Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
    John C Chambers
    Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
    Nat Genet 43:1131-8. 2011
    ..surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or ..
  67. doi Acetate and propionate impact on the methanogenesis of landfill leachate and the reduction of clogging components
    S Lozecznik
    University of Manitoba, Department of Civil Engineering, Winnipeg, Canada MB R3T 5V6
    Bioresour Technol 104:37-43. 2012
    Synthetic leachate with different initial concentrations of acetate (500-2500 mg HAc/L) and propionate (500-3500 mg HPr/L) was treated with active biomass acclimated to landfill leachate under anaerobic mesophilic conditions for 72 h...
  68. pmc Evaluation of a mucoadhesive fenretinide patch for local intraoral delivery: a strategy to reintroduce fenretinide for oral cancer chemoprevention
    Andrew S Holpuch
    Division of Oral Maxillofacial Surgery, Pathology and Anesthesiology, College of Dentistry, The Ohio State University, 2205 Postle Hall, 305 W 12th Avenue, Columbus, OH 43210 1241, USA
    Carcinogenesis 33:1098-105. 2012
    ..65 μM; trace amounts of 4-oxo-4-HPR) and undetectable sera levels...
  69. pmc Fenretinide (4-HPR): a preventive chance for women at genetic and familial risk?
    Massimiliano Cazzaniga
    Division of Cancer Prevention and Genetics, European Institute of Oncology, 20141 Milan, Italy
    J Biomed Biotechnol 2012:172897. 2012
    ..Fenretinide (4-HPR) is the most studied retinoid in breast cancer chemoprevention clinical trials due to its selective accumulation in ..
  70. doi Correlation of platelet reactivity and C-reactive protein levels to occurrence of peri-procedural myocardial infarction in patients undergoing percutaneous coronary intervention (from the ARMYDA-CRP study)
    Giuseppe Patti
    Department of Cardiovascular Sciences, Campus Bio Medico University of Rome, Rome, Italy
    Am J Cardiol 111:1739-44. 2013
    The incremental predictive value of high inflammatory status and high on-treatment platelet reactivity (HPR) on the occurrence of periprocedural myocardial infarction (PMI) after percutaneous coronary intervention (PCI) has not been ..
  71. doi Mechanism of Trypanosoma brucei gambiense resistance to human serum
    Pierrick Uzureau
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12 rue des Prof Jeener et Brachet, B 6041 Gosselies, Belgium
    Nature 501:430-4. 2013
    ..two serum complexes designated trypanolytic factors (TLF-1 and -2), which both contain haptoglobin-related protein (HPR) and apolipoprotein LI (APOL1)...
  72. doi A comparative cohort study on personalised antiplatelet therapy in PCI-treated patients with high on-clopidogrel platelet reactivity. Results of the ISAR-HPR registry
    K Mayer
    Katharina Mayer, MD, Deutsches Herzzentrum Munchen, Lazarettstr 36, 80636 Munich, Germany, Tel 49 89 1218 0, Fax 49 89 1218 4013, E mail
    Thromb Haemost 112:342-51. 2014
    In clopidogrel-treated patients undergoing percutaneous coronary intervention (PCI), high platelet reactivity (HPR) is associated with a higher risk for thrombotic events including stent thrombosis (ST)...
  73. pmc A New Route for High-Purity Organic Materials: High-Pressure-Ramp-Induced Ultrafast Polymerization of 2-(Hydroxyethyl)Methacrylate
    E Evlyukhin
    Laboratoire de Physique des Lasers LPL, CNRS, Universite Paris 13, Sorbonne Paris Cité, 93430 Villetaneuse, France
    Sci Rep 5:18244. 2015
    ..Here, we report a unique process based on a two-step high-pressure ramp (HPR) for the ultrafast and efficient bulk polymerization of 2-(hydroxyethyl)methacrylate (HEMA) at room temperature ..
  74. doi HRT dependent performance and bacterial community population of granular hydrogen-producing mixed cultures fed with galactose
    Gopalakrishnan Kumar
    Sustainable Management of Natural Resources and Environment Research Group, Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Viet Nam Department of Environmental Engineering, Daegu University, Gyeongsan, Gyeongbuk 712 714, South Korea
    Bioresour Technol 206:188-94. 2016
    ..A peak hydrogen production rate (HPR) of 25...
  75. doi [Prevalence of acetylsalicylic acid (ASA) - low response in vascular surgery]
    T Hummel
    Klinik für Gefäßchirurgie, St Josef Hospital, Ruhr Universitat Bochum, Gudrunstraße 56, 44791, Bochum, Deutschland
    Chirurg 87:446-54. 2016
    ..Research has revealed that a decreased antiplatelet effect (low response [LR]/high on-treatment platelet reactivity [HPR]) of acetylsalicylic acid (ASA) and clopidogrel is associated with an increased risk of thromboembolic events...
  76. ncbi Kinetic modeling of hydrogen production rate by photoautotrophic cyanobacterium A. variabilis ATCC 29413 as a function of both CO2 concentration and oxygen production rate
    Siti Fatihah Salleh
    a Centre for Renewable Energy, Universiti Tenaga Nasional, Putrajaya Campus, Kajang, Selangor, Malaysia
    Prep Biochem Biotechnol . 2016
    ..Haldane's noncompetitive inhibition equation has been modified to determine the specific hydrogen production rate (HPR) as a function of both dissolved CO2 concentration (CTOT) and oxygen production rate (OPR)...
  77. doi Assessing fear learning via conditioned respiratory amplitude responses
    Giuseppe Castegnetti
    Department of Psychiatry, Psychotherapy, and Psychosomatics, University of Zurich, Zurich, Switzerland
    Psychophysiology 54:215-223. 2017
    ..Comparing these data with skin conductance responses (SCR) and heart period responses (HPR), we find that, on average, RAR performs similar to SCR in distinguishing CS+ and CS-, but is less sensitive than ..
  78. pmc Sequence analysis and regulation of the hpr locus, a regulatory gene for protease production and sporulation in Bacillus subtilis
    M Perego
    Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037
    J Bacteriol 170:2560-7. 1988
    The hyperproduction of alkaline and neutral proteases is a phenotype of mutation at the hpr locus. This locus has been cloned and sequenced and has been found to code for a protein of 23,718 Mr...
  79. ncbi The aspartyl replacement of the active site histidine in histidine-containing protein, HPr, of the Escherichia coli Phosphoenolpyruvate:Sugar phosphotransferase system can accept and donate a phosphoryl group. Spontaneous dephosphorylation of acyl-phospha
    S Napper
    Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
    J Biol Chem 274:21776-82. 1999
    The active site residue, His(15), in histidine-containing protein, HPr, can be replaced by aspartate and still act as a phosphoacceptor and phosphodonor with enzyme I and enzyme IIA(glucose), respectively...
  80. ncbi A common interface on histidine-containing phosphocarrier protein for interaction with its partner proteins
    G Wang
    Laboratory of Chemical Physics, NIDDK, and the Laboratory of Biochemical Genetics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:16401-3. 2000
    ..An important component of this system is the histidine-containing phosphocarrier protein, HPr, which accepts a phosphoryl group from enzyme I, transfers a phosphoryl group to IIA proteins, and is an allosteric ..
  81. ncbi Retinoid therapy of high-risk neuroblastoma
    C Patrick Reynolds
    Division of Hematology Oncology, Children s Hospital of Los Angeles and the University of Southern California Keck School of Medicine, Los Angeles, CA 90054, USA
    Cancer Lett 197:185-92. 2003
    ..of vitamin A that include all trans-retinoic acid (ATRA), 13-cis-retinoic acid, (13-cis-RA), and fenretinide (4-HPR)...
  82. ncbi [Inhibitory effects on hepatocarcinoma and B16 melanoma cells by N-(4-hydrophenyl) retinamide]
    Li Zhang
    Department of Biochemistry, Shanghai Medical Celloge, Fudan University, Shanghai 200032
    Shi Yan Sheng Wu Xue Bao 36:421-7. 2003
    In this paper, a significantly effect of N-(4-hydrophenyl) retinamide (4-HPR), a derivative of retinoic acid, was observed on inhibition of migration, invasion, cell growth, and induction of apoptosis in hepatoma cells and B16 melanoma ..
  83. pmc Glycerol metabolism and PrfA activity in Listeria monocytogenes
    Biju Joseph
    Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Gebäude E1, 97080 Wurzburg, Germany
    J Bacteriol 190:5412-30. 2008
    ..Under these conditions, a low level of HPr-Ser-P and a high level of HPr-His-P were present in the cells, suggesting that all enzyme IIA (EIIA) (or EIIB) ..
  84. doi N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing
    Hongtao Wang
    Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Mol Cancer Ther 7:2967-76. 2008
    Fenretinide [N-(4-hydroxyphenyl)retinamide (4-HPR)] is cytotoxic in many cancer cell types. Studies have shown that elevation of ceramide species plays a role in 4-HPR cytotoxicity...
  85. doi Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death
    Im Sun Woo
    Department of Pharmacology, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Cancer Lett 276:53-60. 2009
    ..exhibited reduced reactive oxygen species (ROS) generation in response to Bax or N-(4-hydroxyphenyl)retinamide (4-HPR), respectively, which suggests that ROS play a role in the inhibition of cell death by ARF4...
  86. pmc Transcriptional activator YesS is stimulated by histidine-phosphorylated HPr of the Bacillus subtilis phosphotransferase system
    Sandrine Poncet
    Laboratoire de Microbiologie et Genetique Moleculaire, INRA AgroParisTech CNRS, 78850 Thiverval Grignon, France
    J Biol Chem 284:28188-97. 2009
    In low GC content gram-positive bacteria, the HPr protein is the master regulator of carbon metabolism...
  87. doi Cra regulates the cross-talk between the two branches of the phosphoenolpyruvate : phosphotransferase system of Pseudomonas putida
    Max Chavarría
    Systems Biology Program, Centro Nacional de Biotecnologia, 28049 Cantoblanco Madrid, Spain
    Environ Microbiol 15:121-32. 2013
    ..Because FruB (i.e. the EI-HPr-EIIA(Fru) polyprotein) can deliver a high-energy phosphate to the EIIA(Ntr) (PtsN) enzyme of the PTS(Ntr) branch, ..
  88. ncbi Pharmacogenetics of clopidogrel
    Stephen A O'Connor
    Institut de Cardiologie, INSERM U 937, Groupe A C T I O N Groupe Hospitalier Pitié Salpêtrière, 47, Boulevard de l Hopital, 75013 Paris, France
    Curr Pharm Des 18:5309-27. 2012
    ..leaving up to one third of patients with inadequate platelet inhibition or high on-treatment platelet reactivity (HPR), and subsequent increased ischemic cardiovascular events...
  89. doi Antiplatelets in acute coronary syndrome: personal perspectives
    Rossella Marcucci
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Expert Rev Cardiovasc Ther 10:1487-96. 2012
    High platelet reactivity (HPR) during dual-antiplatelet therapy is a marker of vascular risk, in particular stent thrombosis, in patients with acute coronary syndromes...
  90. doi Does the VerifyNow P2Y12 assay overestimate "therapeutic response" to clopidogrel? Insights using short thrombelastography
    Vikram Khanna
    Prof N Curzen, Wessex Cardiothoracic Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, United Kingdom, Tel 44 2380794972, Fax 44 2380795174
    Thromb Haemost 111:1150-9. 2014
    ..A higher proportion of individuals had a result indicating high platelet reactivity (HPR) with s-TEG than VN-P2Y12 in (i) 43 clopidogrel naïve volunteers (95.3% vs 81...
  91. pmc Interaction with enzyme IIBMpo (EIIBMpo) and phosphorylation by phosphorylated EIIBMpo exert antagonistic effects on the transcriptional activator ManR of Listeria monocytogenes
    Arthur Constant Zébré
    INRA, Microbiologie de l Alimentation au Service de la Santé Humaine, UMR1319, Jouy en Josas, France AgroParisTech, Microbiologie de l Alimentation au Service de la Santé Humaine, UMR1319, Jouy en Josas, France
    J Bacteriol 197:1559-72. 2015
    ..activated via the phosphorylation of His585 in the EIIA(Man)-like domain by the general PTS components enzyme I and HPr. We also show that ManR is regulated by the PTS(Mpo) and that EIIB(Mpo) plays a dual role in ManR regulation...
  92. doi PTS-Mediated Regulation of the Transcription Activator MtlR from Different Species: Surprising Differences despite Strong Sequence Conservation
    Philippe Joyet
    INRA, Microbiologie de l Alimentation au service de la Santé Humaine MICALIS, UMR1319, Jouy en Josas, France
    J Mol Microbiol Biotechnol 25:94-105. 2015
    ..casei MtlR is not phosphorylated by Enzyme I (EI) and HPr. When the corresponding His in PRD2 of MtlR from B. subtilis and G...
  93. pmc A Potential Role of Flag Leaf Potassium in Conferring Tolerance to Drought-Induced Leaf Senescence in Barley
    Seyed A Hosseini
    Molecular Plant Nutrition Group, Physiology and Cell Biology, Leibniz Institute of Plant Genetics and Crop Plant Research Gatersleben, Germany
    Front Plant Sci 7:206. 2016
    ..Relative to the drought-sensitive line LPR, the line HPR retained more K in its flag leaves under low K supply and showed delayed flag leaf senescence under terminal ..
  94. pmc Mannitol-specific phosphoenolpyruvate-dependent phosphotransferase system of Enterococcus faecalis: molecular cloning and nucleotide sequences of the enzyme IIIMtl gene and the mannitol-1-phosphate dehydrogenase gene, expression in Escherichia coli, and c
    R Fischer
    Ruhr Universitat Bochum, Gebäude NDEF, Bochum, Federal Republic of Germany
    J Bacteriol 173:3709-15. 1991
    ..It is phosphorylated in a reaction sequence requiring enzyme I and heat-stable phosphocarrier protein (HPr)...
  95. ncbi The transition state regulator Hpr of Bacillus subtilis is a DNA-binding protein
    P T Kallio
    Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, La Jolla, California 92037
    J Biol Chem 266:13411-7. 1991
    ..One of these regulators is the product of the hpr gene, first identified by mutations affecting the synthesis of extracellular proteases...
  96. pmc Physiological consequences of the complete loss of phosphoryl-transfer proteins HPr and FPr of the phosphoenolpyruvate:sugar phosphotransferase system and analysis of fructose (fru) operon expression in Salmonella typhimurium
    D A Feldheim
    Department of Biology, University of California, San Diego, La Jolla 92093
    J Bacteriol 172:5459-69. 1990
    ..Other experiments indicated that sugar uptake via the PTS can utilize either FPr-P or HPr-P as the phosphoryl donor, but that FPr is preferred for fructose uptake whereas HPr is preferred for uptake of the ..
  97. ncbi Sugar transport by the bacterial phosphotransferase system. Molecular cloning and structural analysis of the Escherichia coli ptsH, ptsI, and crr genes
    D W Saffen
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218
    J Biol Chem 262:16241-53. 1987
    ..These genes encode three cytoplasmic proteins of the phosphoenol-pyruvate:glycose phosphotransferase system: HPr, Enzyme I, and IIIGlc, respectively...
  98. ncbi Cloning and characterization of the Bacillus subtilis prkA gene encoding a novel serine protein kinase
    C Fischer
    Institut de Biologie et Chimie des Proteines, CNRS, Lyon, France
    Gene 168:55-60. 1996
    ..An Escherichia coli strain, LBG1605, carrying a mutated ptsH gene (encoding HPr (His-containing protein) of the bacterial phosphotransferase system (PTS)) and complemented for PTS activity with ..
  99. ncbi Mutation of serine-46 to aspartate in the histidine-containing protein of Escherichia coli mimics the inactivation by phosphorylation of serine-46 in HPrs from gram-positive bacteria
    S Napper
    Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada
    Biochemistry 35:11260-7. 1996
    Histidine-containing protein (HPr) is a phosphocarrier protein of the bacterial phosphoenolpyruvate:sugar phosphotransferase system...
  100. ncbi Energetic implications for protein phosphorylation. Conformational stability of HPr variants that mimic phosphorylated forms
    M E Huffine
    Department of Medical Biochemistry, Texas A and M University, College Station, Texas 77843, USA
    J Biol Chem 271:28898-902. 1996
    The HPr protein from Bacillus subtilis is a key protein in the phosphoenolpyruvate-sugar transport system. HPr has two biological phosphorylation sites...
  101. ncbi The structure of enzyme IIAlactose from Lactococcus lactis reveals a new fold and points to possible interactions of a multicomponent system
    P Sliz
    Department of Biochemistry, University of Toronto, ON, Canada
    Structure 5:775-88. 1997
    ..The PTS consists of two non-specific energy coupling components, enzyme I and a heat stable phosphocarrier protein (HPr), as well as several sugar-specific multiprotein permeases known as enzymes II...

Research Grants73

  1. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2012
    ..results show that a combination of therapeutically achievable concentration of As2O3 with fenretinide (4-HPR), a retinoid approved for clinical trials, synergizes in causing apoptosis in AML cells which express detectable (..
  2. Novel L-threo-sphinganines for ceramides-based cancer therapy
    Barry J Maurer; Fiscal Year: 2012
    ..to act as synergizing agents for the dihydroceramide-increasing, cytotoxic retinoid, fenretinide (4-HPR). Ceramides are sphingolipids with pro- death signaling properties...
  3. A Phase I trial combining fenretinide and safingol to target overproduction of di
    CHARLES PATRICK REYNOLDS; Fiscal Year: 2012
    ..Maurer, MD PhD ABSTRACT Fenretinide (4-HPR) is a p53-independent retinoid selectively cytotoxic to cancer cells via increase of reactive oxygen species and ..
  4. DIFFERENTIATION AND APOPTOSIS IN MALIGNANT NEUROBLASTOMA
    Swapan Ray; Fiscal Year: 2009
    ..all-trans-retinoic acid (ATRA), 13-cis-retinoicacid (13-CRA), and fenretinide [N-(4-hydroxyphenyl) retinamide or 4-HPR] induce differentiation in 5 human neuroblastoma cell lines (SH-SY5Y, SK-N-BE2, SK-N-DZ, IMR-32, and SK-N-MC)...
  5. TAMOXIFEN AND RETINOIC ACID EFFECT ON THE UTERUS
    Kenneth Nephew; Fiscal Year: 2000
    ..We will carry out a detailed analysis of the molecular effects of tamoxifen and 4-HPR (fenretinide; a retinoic acid derivative) on the uterine endometrium...
  6. PREDICTION AND MODIFICATION OF MELANOMA RISK
    DuPont Guerry; Fiscal Year: 2000
    ..Project 2 utilizes a randomized trial of topical tretinoin and 4-HPR (fenretinide) to test chemoprevention in another cohort with dysplastic nevi...
  7. Correlative trial of fenretinide against Glioblastomas
    VINAY PUDUVALLI; Fiscal Year: 2003
    ..induces apoptosis in tumor tissue and correlate the degree of apoptosis with serum and tissue concentrations of 4-HPR and with clinical efficacy...
  8. PHASE III STUDY OF FENRETINIDE IN BLADDER CARCINOFENESIS
    Scott Lippman; Fiscal Year: 2001
    ..We propose a phase III clinical trial of fenretinide (4-HPR), to be of intermediate duration (15 months) and size (160 evaluable patients), in preventing superficial bladder ..
  9. TRANSLATIONAL RESEARCH IN BREAST CANCER
    Beth Overmoyer; Fiscal Year: 2004
    ..This study will also determine if 4-HPR therapy induces in vivo expression of TIG3, a novel gene involved with apoptosis, in treated patients, and confirm ..
  10. Parenteral Formulations for Synthetic Retinoids
    Earle Holsapple; Fiscal Year: 2005
    ..the lead product, develop a documented manufacturing process that could be implemented in a sterile product facility in Phase 3, and understand the physiological and pharmacological principles that govern tissue distribution of HPR.
  11. Novel Ceramide-based Chemotherapy for Acute Leukemia
    Barry Maurer; Fiscal Year: 2007
    ..We reported that fenretinide (4-HPR) increased de novo ceramide synthesis in cancer cell lines in vitro, and inhibitors of ceramide catabolism, such as ..
  12. RETINOID THERAPY OF NEUROBLASTOMA
    Charles Reynolds; Fiscal Year: 2000
    ..We discovered that the RA derivative N-(4-hydroxyphenyl) retinamide (fenretinide; 4-HPR) is highly cytotoxic for NBL cell lines that are resistant to 13-cis-RA...
  13. IGF-I MODULATION BY 4-HPR AND BREAST CANCER RISK
    Umberto Veronesi; Fiscal Year: 1999
    ..aged less that 50 years, on intervention with the synthetic retinoid 4-(hydroxyphenyl) retinamide (fenretinide or 4-HPR)...
  14. PHOSPHOENOLPYRUVATE: GLYCOSE PHOSPHOTRANSFERASE SYSTEM
    Saul Roseman; Fiscal Year: 2004
    ..The P-transfer sequence is via 4 proteins: PEP <-> Enzyme I (EI) <-> HPr <-> IIAGlc (or IIIGlc) <-> IICBGlc -> Glc...
  15. Stephen L Hajduk; Fiscal Year: 2014
    ..contains apolipoprotein A-1 (apoA-1), a protein found in all HDLs, and two primate specific proteins, haptoglobin related protein (Hpr) and apolipoprotein L-1 (apoL-1)...
  16. Samuel A Shelburne; Fiscal Year: 2015
    ..sites in conjunction with its co-factor histidine-containing phosphoprotein phosphorylated at serine residue 46 (HPr-Ser46-P)...
  17. GENETIC DISSECTION OF PROGESTERONE RECEPTOR FUNCTION
    Donald McDonnell; Fiscal Year: 2004
    ..with the discovery that this receptor can exist in either of two functionally-distinct forms within target cells: hPR-A and hPR-B...
  18. PLASMA PROTEINS: MARKERS OF CHEMICAL EXPOSURE
    GHULAM ANSARI; Fiscal Year: 1991
    ..be selected to participate in a two-year chemoprevention clinical trial in which they will be administered either 4-HPR or a placebo and monitored at 6 month intervals with OFIA and Pap cytology...
  19. ANALOG STUDIES OF 4-HPR AND ITS GLUCURONIDE
    Robert W Curley; Fiscal Year: 2013
    ..The synthetic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR) shows some unique activity as a breast cancer chemopreventive with further reduced toxicity and teratogenicity...
  20. Origin of Virulence Factors in African Trypanosomes
    ANDREW MCARTHUR; Fiscal Year: 2004
    ..The active component of TLF is the primate specific haptoglobin related protein (HPR). This protein is the sole factor preventing infection of humans by T. b...
  21. PHYSIOLOGIC CHARACTERISTICS OF TREPONEMA PALLIDUM
    Steven Norris; Fiscal Year: 2004
    ..A unique aspect of the T. pallidum genome i that it encodes HPr (PtsH), the HPr(ser) kinase (PtsK), a frameshifted Enzyme I (PtsI) and two additiona potential regulatory PTS ..
  22. MDA-7/IL-24 and free radicals in renal cancer therapy
    Paul Dent; Fiscal Year: 2009
    ..Additionally, we will prove or refute whether [arsenic trioxide (As2O3) and N-(4-hydroxyphenyl) retinamide (4-HPR)], agents that generate reactive oxygen species, enhance the ability of low GST-MDA-7 concentrations (0.5-1...
  23. Mitochondrial GRHPR and Hyperoxaluria
    Scott Cramer; Fiscal Year: 2006
    ..that catalyzes conversion of glyoxylate to glycolate (GR), conversion of hydroxypyruvate to D-glycerate (HPR), and conversion of D-glycerate to hydroxypyruvate (DGDH)...
  24. 'IN VITRO SCREENING OF SELECTED CHEMOPREVENTIVE AGENTS U
    David McCormick; Fiscal Year: 2000
    ..Four chemopreventive compounds belonging to the class of antiproliferative agents, 4 HPR, DFMO, Sulindac, and Perillyl Alcohol are being used at five doses in a nontoxic range...
  25. HISTORY AND CONTROL OF THE HAPTOGLOBIN GENE CLUSTER
    Nobuyo Maeda; Fiscal Year: 1999
    ..will test whether or not the retrovirus- like sequence in the first intron of the human haptoglobin related gene (HPR) is, as we have hypothesized, responsible for inactivation of this gene...
  26. LOW DOSE TAMOXIFEN AND 4HPR IN EARLY BREAST CANCER
    Andrea Decensi; Fiscal Year: 2000
    ..aim of the present project is the search for an interaction between low-dose tamoxifen and the synthetic retinoid 4-HPR on a set of surrogate endpoint biomarkers (SEBs) in premenopausal women with in situ or minimally invasive breast ..
  27. HIERARCHY OF PROTEIN FOLDING AND STABILITY
    J Scholtz; Fiscal Year: 1999
    ..The HPr protein from bacteria is an ideal vehicle for those studies since the proteins from both Escherichia coli and ..
  28. BRUCE A MC CLANE; Fiscal Year: 2016
    ..isolates is dn a mobilizable transposon, and determining whether two component regulatory systems and/or the exponential growth phase repressor Hpr play a role in regulating the sporulation-associated expression of CPE.
  29. TARGETING CERAMIDE METABOLISM FOR CANCER TREATMENT
    Myles Cabot; Fiscal Year: 2003
    ..synthase (GCS), will be exposed to conventional chemotherapy, Adriamycin, Taxol, N-4(hydroxyphenyl)retinamide(4-HPR) in the absence or presence of agents that retard ceramide glycosylation, the latter being evaluated through ..
  30. REGULATION OF HEPATIC RETINOL METABOLISM
    A Ross; Fiscal Year: 2000
    ..hormone, retinoic acid (RA) and well as by exogenous, synthetic retinoids such as 4-(N-hydroxyphenyl) retinamide (4-HPR)...
  31. UPSTREAM ACTIVATION OF BACILLUS PROMOTERS
    JAMES HOCH; Fiscal Year: 1990
    ..The regulatory genes, sacU, sacQ, prtR, and hpr pleiotropically affect the synthesis of several enzymes including levansucrase, sacB, and alkaline protease, aprE...
  32. Secreted Proteins as Breast Cancer Prevention Markers
    Michael Gould; Fiscal Year: 2007
    ..Drugs to be used include: the monoterpene Perillyl alcohol; the retinoids 9-cis retinoic acid (or Targretin) and 4-HPR; the COX-2 inhibitor Celecoxib; and an EGFR kinase inhibitor...
  33. ANTI-TUMOR ACTIVITY OF GLUCARATE AND HPR
    Thomas Webb; Fiscal Year: 1993
    ..e. ineffective) doses, synergistically with other agents such as N-(4-hydroxyphenyl)retinamide (HPR) to inhibit tumor growth and in fact cause tumor shrinkage. When given p.o...
  34. Xenograft models of human neuroblastoma bone metastases.
    Charles Reynolds; Fiscal Year: 2004
    ..We anticipate that this project will increase our understanding of the biology of bone metastases and will develop mouse models for pre-clinical testing of new therapeutic approaches to high risk neuroblastoma. ..
  35. Whole genome amplification and DNA pooling strategies
    Immaculata DeVivo; Fiscal Year: 2004
    ..Results from the pooling experiments will determine whether this method may be sensitive enough for use in nested case-control studies where a small difference in allele frequency is expected. ..
  36. Regulation of Pulmonary Vascular Tone During Cirrhosis
    CHRYSTELLE GARAT CARTER; Fiscal Year: 2004
    ..This project will not only define the cellular basis for hepatopulmonary syndrome, but will also contribute to our understanding of how pulmonary vascular tone is controlled at the most basic level. ..
  37. Regulation of Vascular Tone During Cirrhosis
    ETHAN CARTER; Fiscal Year: 2003
    ..This project will not only define the cellular basis for hepatopulmonary syndrome, but will also contribute to our understanding of how pulmonary vascular tone is controlled at the most basic level. ..
  38. Structural studies on the P1 plasmid partition apparatus
    Maria Schumacher; Fiscal Year: 2009
    ....
  39. Structural mechanism of DNA segregation by the pSK41 par system
    Maria Schumacher; Fiscal Year: 2010
    ..Thus, understanding the structural basis for DNA segregation by this par system will provide several points of potential therapeutic intervention against pSK41 harboring multidrug resistant S. aureus strains. ..
  40. Structural studies on the Initiator protein, IBP39.
    Maria Schumacher; Fiscal Year: 2008
    ..vaginalis suggests it is a possible target for the treatment of trichomoniasis, which afflicts over 170 million individuals each _,ear, ..
  41. ROLE OF MISMATCH REPAIR IN SPORADIC TUMOR SUPPRESSION
    Guo Min Li; Fiscal Year: 2004
    ..This study will not only provide insight into the etiology of sporadic bladder cancers, but also lead to the identification of novel mismatch repair components. ..
  42. Role of Oxidants & Angiogenesis in Kaposi's Sarcoma
    Susan Mallery; Fiscal Year: 2007
    ..Elucidation of these interactions will not only clarify KS pathogenic mechanisms, but will also identify sites for KS therapeutic intervention. ..
  43. Formulation & Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention
    Susan Mallery; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  44. Mechanism of PCNA-dependent 5'->3' Mismatch Excision
    Guo Min Li; Fiscal Year: 2010
    ..g., the EXO1 gene, are associated with cancer development, identifying the components required for the novel 5'excision pathway will provide new diagnostic markers for HNPCC and other MMR deficient cancer syndromes. ..
  45. Chemoprevention of Oral Dysplasia by Black Raspberries
    Susan Mallery; Fiscal Year: 2005
    ..This experimental design (comparison of pretreatment and post-treatments tissues) permits each patient to serve as their own internal control. ..
  46. Identifying Proteins Involved in DNA Damage Response
    Guo Min Li; Fiscal Year: 2005
    ..Because certain cancer chemotherapeutics, e.g., cisplatin and alkylating agents, can signal apoptosis in an MMR-dependent fashion, this study will also impact cancer treatment, particularly cancers caused by MMR defects. ..
  47. Dissection and Reconstitution of Human Mismatch Repair
    Guo Min Li; Fiscal Year: 2009
    ..abstract_text> ..
  48. Case-Control Study of Pancreas Cancer Etiologic Factors
    Harvey Risch; Fiscal Year: 2008
    ..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. [unreadable] [unreadable]..
  49. Amplification of Custom RNA in Plants
    SERGEI KAZAKOV; Fiscal Year: 2002
    ..Our current business strategy is to sell custom RNA in partnership with Large Scale Biology Corp. and license the technology to certain other manufacturers. ..
  50. Library-based selection of optimal gene inhibitors
    SERGEI KAZAKOV; Fiscal Year: 2003
    ..In this way, optimized Lassos will be derived in an automatic and straightforward manner for application as agents for target validation, gene function analysis, and therapeutics. ..
  51. LOCAL AND LONG RANGE INTERACTIONS IN PROTEIN FOLDING
    J Scholtz; Fiscal Year: 2004
    ..abstract_text> ..
  52. Apoptotic effect of zinc in targeting prostate cancer
    Pei Feng; Fiscal Year: 2009
    ..The elucidation of the molecular basis of the cell specific response to zinc restoration in prostate cancer cells will contribute to the development of new approaches to the treatment of prostate cancer. ..
  53. Multiplexed mRNA quanitification using self-circularizing RNA probes
    SERGEI KAZAKOV; Fiscal Year: 2008
    ..This system will be particularly useful for RNAi-based drugs that are currently in development for several disorders, including HCV, where the ability to monitor target knock-down and off-target effects is important. [unreadable]..
  54. P27Kipl deficiency, potential promoter of carcinogenesis
    Konstantin Christov Tzelkov; Fiscal Year: 2003
    ..abstract_text> ..
  55. 2nd International Cervical Cancer Conference
    Michele Follen; Fiscal Year: 2002
    ..Each session chair and speaker has been chosen based on his/her publications, funding and national reputation. ..
  56. CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGY
    Harvey Risch; Fiscal Year: 2002
    ....
  57. DNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDY
    Harvey Risch; Fiscal Year: 2002
    ..abstract_text> ..
  58. A new method for multiplex detection of micro-RNAs (miR-ID)
    SERGEI KAZAKOV; Fiscal Year: 2008
    ..The method of micro-RNA detection has novel features that promise better sensitivity and selectivity than other micro-RNA assays currently available. [unreadable] [unreadable] [unreadable] [unreadable]..
  59. Mechanism of SHeA2 Action in Ovarian Cancer
    Doris Benbrook; Fiscal Year: 2009
    ..The elucidation of the proteins involved in the SHetA2 pathwayswill provide potential biomarkers for ovarian cancer diagnosis, prevention and treatment strategies. ..
  60. Rexinoid Synergy in Prostate Cancer Apoptosis
    Marcia Dawson; Fiscal Year: 2009
    ..We anticipate that our results will provide a more effective and less systemically toxic means of enhancing the efficacy of chemotherapeutic agents currently used to treat prostate cancer. ..
  61. In Vitro Cancer Prevention Biomarker Development
    Eugene Elmore; Fiscal Year: 2004
    ..Using cluster analysis, we will determine the global gene expression changes induced by each agent. The strength of the proposed approach lies in the high quality data that has already determined from the HEC Assay. ..
  62. Brain tumor angiogenesis: Integrin ceramide signaling
    Anat Erdreich Epstein; Fiscal Year: 2008
    ..abstract_text> ..
  63. Influence of genotype on urinary oxalate excretion
    CARLA MONICO; Fiscal Year: 2007
    ..enzymes (alanine:glyoxylate aminotransferase or AGT in PHI, and glyoxylate:hydroxypyruvate reductase or GR/HPR in PHII) but clinically relevant correlations between genotype and phenotype are currently lacking...
  64. Ceramide in angiogenic integrin signaling
    Anat Erdreich Epstein; Fiscal Year: 2006
    ....
  65. PPMP as a Ceramide Catabolism Inhibitor for Chemotherapy
    Barry Maurer; Fiscal Year: 2003
    ..of ceremide catabolism, in order to enhance the anti-cancer activity of the cytotoxic retinoid, fenretinide (4-HPR)...
  66. Cell Biology of Human Thiamine Transporters
    VEEDAMALI SUBRAMANIAN; Fiscal Year: 2005
    ....
  67. Directed Libraries of Self-Circularizing Antisense RNA
    SERGEI KAZAKOV; Fiscal Year: 2004
    ..They should find diverse applications, includinginhibitingthe expression of disease-related genes, functional genomics, and target validation. ..
  68. Steroids and Stem Cell in Carcinogenesis
    Doris Benbrook; Fiscal Year: 2004
    ..This research will enhance our understanding of the process of carcinogenesis and chemoprevention, which could ultimately translate into strategies and pharmaceuticals for prevention of cancer. ..
  69. ATP-DEPENDENT PROTEIN KINASES IN GRAM-POSITIVE BACTERIA
    Milton Saier; Fiscal Year: 2004
    ..our model organism, by phosphorylating seryl residue-46 in the paralogous phosphocarrier proteins of the PTS, HPr (the major co-repressor present in all low G+C Gram-positive bacteria) and Crh (the minor co-repressor present only ..