Genomes and Genes
Gene Symbol: HPR
Description: haptoglobin-related protein
Alias: A-259H10.2, haptoglobin-related protein, Haptoglobin-related locus
Publications316 found, 100 shown here
- Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or IICarla G Monico
Division of Nephrology, General Clinical Research Center, Mayo Clinic Rochester, Minnesota 55905, USA
Kidney Int 62:392-400. 2002..Hepatic alanine:glyoxylate aminotransferase (AGT) or glyoxylate/hydroxypyruvate reductase (GR/HPR) deficiency causes PHI or PHII, respectively...
- Sinorhizobium meliloti mutants lacking phosphotransferase system enzyme HPr or EIIA are altered in diverse processes, including carbon metabolism, cobalt requirements, and succinoglycan productionCatalina Arango Pinedo
Department of Molecular and Cell Biology, University of Connecticut, 91 N Eagleville Rd, U 3125, Storrs, CT 06269 3125, USA
J Bacteriol 190:2947-56. 2008..meliloti. The genes present code for Hpr and ManX (an EIIA(Man)-type enzyme). HPr and EIIA regulate carbon utilization in other bacteria...
- Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like elementN Maeda
J Biol Chem 260:6698-709. 1985Thirty-three kilobase pairs (kb) of human DNA containing the haptoglobin (Hp) and haptoglobin-related (Hpr) gene pair were cloned, and the nucleotide sequence of 21-kb DNA was determined...
- Killing of trypanosomes by the human haptoglobin-related proteinA B Smith
Department of Biochemistry and Molecular Genetics, School of Medicine and Dentistry, University of Alabama at Birmingham 35294, USA
Science 268:284-6. 1995..An antibody to haptoglobin inhibited TLF activity. TLF was shown to exhibit peroxidase activity and to be inhibited by catalase. These results suggest that TLF kills trypanosomes by oxidative damage initiated by its peroxidase activity...
- Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serumBenoit Vanhollebeke
Laboratory of Molecular Parasitology, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
Proc Natl Acad Sci U S A 104:4118-23. 2007..Another HDL component, haptoglobin-related protein (Hpr), has been suggested as an additional toxin required for full trypanolytic activity of normal human serum...
- Characterization of the human serum trypanosome toxin, haptoglobin-related proteinM Muranjan
New York University Medical Center, Department of Pathology, New York, New York 10016, USA
J Biol Chem 273:3884-7. 1998Haptoglobin-related protein (HPR) is a serum protein that is >90% homologous to the acute-phase reactant haptoglobin (Hp). Haptoglobin binds and removes free hemoglobin (Hb) from the circulation...
- Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma proteinMarianne Jensby Nielsen
Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark
Blood 108:2846-9. 2006Haptoglobin-related protein (Hpr) is a primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL) particles shown to be a part of the innate immune defense...
- Catabolite repression and inducer control in Gram-positive bacteriaM H Saier
Department of Biology, University of California at San Diego, La Jolla 92093 0116, USA
Microbiology 142:217-30. 1996..available clearly indicate that the metabolite-activated protein kinase-mediated phosphorylation of Ser-46 in HPr plays a key role in catabolite repression and the control of inducer levels in low-GC Gram-positive bacteria...
- Cancer risk factors for selecting cohorts for large-scale chemoprevention trialsP Greenwald
Division of Cancer Prevention and Control, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Cell Biochem Suppl 25:29-36. 1996..Trial (tamoxifen), the Prostate Cancer Prevention Trial (finasteride), and the N-(4-hydroxyphenyl) retinamide (4-HPR) breast cancer prevention study being conducted in Milan...
- Distribution of free amino acids in streptozotocin-induced diabetic pregnant rats, their placentae and fetusesA D Copeland
Department of Physiology and Endocrinology, Medical College of Georgia, Augusta
Horm Metab Res 22:65-70. 1990..Placental levels of Tau, Gln, HPr, Thr and Lys were depressed in the diabetic animals and insulin treatment only partially improved these amino acid ..
- Loss of protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system, by mutation of the ptsH gene confers catabolite repression resistance to several catabolic genes of Bacillus subtilisJ Deutscher
Max Planck Institute for Molecular Physiology, Dortmund, Germany
J Bacteriol 176:3336-44. 1994In gram-positive bacteria, HPr, a phosphocarrier protein of the phosphoenolpyruvate:sugar phosphotransferase system (PTS), is phosphorylated by an ATP-dependent, metabolite-activated protein kinase on seryl residue 46...
- Acute hyperleptinemia does not modify insulin sensitivity in vivo in the ratP S Widdowson
Department of Medicine, Liverpool University, UK
Horm Metab Res 30:259-62. 1998..clamping were not different between leptin-infused and control rats, and there were no significant effects on the HPR or WBU measured using [6-(3)H]glucose under basal or clamped conditions...
- Chemoprevention of breast cancerM P Osborne
Department of Surgery, Cornell University Medical College, New York, New York, USA
Surg Clin North Am 79:1207-21. 1999..Based on experimental studies, the vitamin A analogue 4-hydroxyphenyl retinamide (4-HPR) was shown to delay and reduce carcinogen-induced breast cancer...
- Inhibition of the phosphoenolpyruvate:lactose phosphotransferase system and activation of a cytoplasmic sugar-phosphate phosphatase in Lactococcus lactis by ATP-dependent metabolite-activated phosphorylation of serine 46 in the phosphocarrier protein HPrJ J Ye
Department of Biology, University of California at San Diego, La Jolla 92093 0116
J Biol Chem 269:11837-44. 1994..Intravesicular (but not extravesicular) wild-type HPr of Bacillus subtilis completely restored the regulatory behavior observed in vivo when glucose was present in the ..
- Executive Summary of the National Cancer Institute Workshop: Highlights and recommendationsR Lieberman
National Cancer Institute, Rockville, Maryland, USA
Urology 57:4-27. 2001..research program and began testing the first generation of promising agents (eg, 4-(hydroxy)-fenretinide [4-HPR], difluoromethylornithine [DFMO], antiandrogens) in high-risk cohorts and launched the first-large scale US phase 3 ..
- Ligand-activated progesterone receptor isoform hPR-A is a stronger transactivator than hPR-B for the expression of IGFBP-1 (insulin-like growth factor binding protein-1) in human endometrial stromal cellsJ Gao
Department of Obstetrics Gynecology and Reproductive Medicine, School of Medicine, State University of New York at Stony Brook, 11794, USA
Mol Endocrinol 14:1954-61. 2000In human endometrium, the levels of progesterone receptor (PR) isoforms hPR-A and hPR-B are differentially regulated during the reproductive cycle...
- [Chronic dizziness in elderly people: its clinical characteristics and magneto-encephalographic findings]Hiroaki Naritomi
Department of Cerebrovascular Medicine, National Cardiovascular Center
Rinsho Shinkeigaku 48:393-400. 2008..can be hypothecated on the basis of MEG findings as follows: Presumably, there are head-position recognizing (HPR) centers in the left and right cerebral hemispheres...
- Catabolite repression of dra-nupC-pdp operon expression in Bacillus subtilisX Zeng
Department of Microbiology, Technical University of Denmark, Building 301, DK 2800 Lyngby, Denmark
Microbiology 146:2901-8. 2000..repression of dra-nupC-pdp expression was relieved in a ccpA mutant and was found to be dependent on both HPr and the HPr-like protein Crh...
- Functional interactions between proteins of the phosphoenolpyruvate:sugar phosphotransferase systems of Bacillus subtilis and Escherichia coliJ Reizer
Department of Biology, University of California at San Diego, La Jolla 92093 0116
J Biol Chem 267:9158-69. 1992..The proteins isolated include Enzyme I, HPr, the glucose-specific IIA domain of the glucose-specific Enzyme II (IIAglc), and the mannitol-specific IIA protein, ..
- Mutual self-defence: the trypanolytic factor storyEtienne Pays
Laboratory of Molecular Parasitology, Universite Libre de Bruxelles, Gosselies, Belgium
Microbes Infect 10:985-9. 2008..binds to a subset of HDL particles that also contain another human-specific protein, haptoglobin-related protein or Hpr. T. b...
- Chemoprevention of breast cancer with fenretinide (4-HPR): study of long-term visual and ophthalmologic tolerabilityL Mariani
Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
Tumori 82:444-9. 1996BACKGROUND: Fenretinide (4-HPR) is a synthetic retinoid being clinically tested in the chemoprevention of different tumors and precancerous lesions...
- The significance of the 20-carbonyl group of progesterone in steroid receptor binding: a molecular dynamics and structure-based ligand design studyAlexander Hillisch
EnTec GmbH, Adolf Reichwein Str 20, D 07745 Jena, Germany
Steroids 68:869-78. 2003..Also site-directed mutagenesis studies of the human progesterone receptor (hPR) suggest an important role for Cys891 in the recognition of the progesterone 20-carbonyl group...
- Chemoprevention trial of contralateral breast cancer with fenretinide. Rationale, design, methodology, organization, data management, statistics and accrualG De Palo
Istituto Nazionale Tumori, University of Milan, Italy
Tumori 83:884-94. 1997The Fenretinide (4-HPR) Breast Cancer Study is a randomized multicenter clinical trial originally designed and conducted by the investigators of the Istituto Nazionale Tumori of Milan...
- Modulation of Escherichia coli adenylyl cyclase activity by catalytic-site mutants of protein IIA(Glc) of the phosphoenolpyruvate:sugar phosphotransferase systemP Reddy
Biotechnology Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 0001, USA
J Bacteriol 180:732-6. 1998..75 has been replaced by glutamine, were phosphorylated by the phosphohistidine-containing phosphocarrier protein (HPr-P) and were equally potent activators of adenylyl cyclase...
- Structural consequences of histidine phosphorylation: NMR characterization of the phosphohistidine form of histidine-containing protein from Bacillus subtilis and Escherichia coliP Rajagopal
Department of Biochemistry, University of Washington, Seattle 98195
Biochemistry 33:15271-82. 1994..Histidine-containing protein (HPr) is phosphorylated on the N delta 1 position of the imidazole ring of His15 by enzyme I and acts as a phosphoryl ..
- Identification by NMR of the binding surface for the histidine-containing phosphocarrier protein HPr on the N-terminal domain of enzyme I of the Escherichia coli phosphotransferase systemD S Garrett
Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
Biochemistry 36:4393-8. 1997..5 kDa histidine-containing phosphocarrier protein HPr of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system has been investigated by heteronuclear ..
- In vitro effects of fenretinide on cell-matrix interactionsM Vaccari
Istituto Nazionale per la Ricerca sul Cancro, Genova Biotechnology Satellite Unit, Bologna, Italy
Anticancer Res 20:3059-66. 2000..Fenretinide (4-HPR), a synthetic derivative of retinoic acid, is less toxic than natural retinoids and is active in the prevention and ..
- Inhibition of neuroblastoma-induced angiogenesis by fenretinideD Ribatti
Department of Human Anatomy and Histology, University of Bari, Bari, Italy
Int J Cancer 94:314-21. 2001..The synthetic retinoid fenretinide (HPR) inhibits carcinogenesis in various animal models...
- Pineal gland abnormalities in Langerhans cell histiocytosisN Grois
Children s Cancer Research Institute, St Anna Children s Hospital, Vienna, Austria
Pediatr Blood Cancer 43:261-6. 2004..CNS) disease in Langerhans cell histiocytosis (LCH) comprise involvement of the hypothalamic-pituitary region (HPR) and neurodegenerative changes in the cerebellum, basal ganglia or pons...
- Accrual issues for chemoprevention trials: the example of the 4-HPR study for the prevention of contralateral breast cancerT Camerini
Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
Tumori 85:299-303. 1999..The known accrual difficulties of chemoprevention studies proved also to be true for the high-risk population of this trial...
- High affinity binding and allosteric regulation of Escherichia coli glycogen phosphorylase by the histidine phosphocarrier protein, HPrY J Seok
NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 272:26511-21. 1997The histidine phosphocarrier protein (HPr) is an essential element in sugar transport by the bacterial phosphoenolpyruvate:sugar phosphotransferase system...
- Fenretinide breast cancer prevention trial: drug and retinol plasma levels in relation to age and disease outcomeFranca Formelli
Istituto Nazionale Tumori, 20133 Milan, Italy
Cancer Epidemiol Biomarkers Prev 12:34-41. 2003To assess, in women participating in a breast cancer prevention trialon fenretinide (4-HPR), the relationship of drug and retinol levels with the risk of second breast malignancy, taking into account age and menopausal status.
- Expression of the progesterone receptor and progesterone- metabolising enzymes in the female and male human kidneyC Bumke-Vogt
Department of Endocrinology, Klinikum Benjamin Franklin, Freie Universitat Berlin, Germany
J Endocrinol 175:349-64. 2002..As a prerequisite for sequestration of progesterone by binding to the human progesterone receptor (hPR) we demonstrated the existence of hPR expression in female and male kidney cortex and medulla at the level of ..
- Structure of the IIA domain of the glucose permease of Bacillus subtilis at 2.2-A resolutionD I Liao
Center for Advanced Research in Biotechnology, Maryland Biotechnology Institute, Rockville 20850
Biochemistry 30:9583-94. 1991..His83, the histidyl residue which is the phosphorylation target of HPr and which transfers the phosphoryl group to the IIB domain of the permease, is located at the C-terminus of a beta-..
- Protein kinase-dependent HPr/CcpA interaction links glycolytic activity to carbon catabolite repression in gram-positive bacteriaJ Deutscher
, CNRS, Lyon, France
Mol Microbiol 15:1049-53. 1995..CcpA-his immobilized on a Ni-NTA resin specifically interacted with HPr phosphorylated at seryl residue 46...
- African trypanosomes: intracellular trafficking of host defense moleculesApril M Shiflett
Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
J Eukaryot Microbiol 54:18-21. 2007..HDL), containing apolipoprotein A-I (APOA1), apolipoprotein L-I (APOL1) and haptoglobin-related protein (HPR) provides this innate protection against T. b. brucei infection. Both HPR and APOL1 are cytotoxic to T. b...
- Hyperintense putaminal rim at 3T reflects fewer ferritin deposits in the lateral marginal area of the putamenS Fujii
Division of Radiology, Department of Pathophysiological and Therapeutic Science, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
AJNR Am J Neuroradiol 28:777-81. 2007The aim of this study was to clarify the cause of hyperintense putaminal rim (HPR) on the basis of 3T MR imaging-pathologic correlations.
- Characterization of infectious bursal disease viruses from four layer flocks in the United StatesB Sreedevi
Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
Avian Dis 51:845-50. 2007..The sequence of HPR-2 was similar to the Bursa Vac 4 vaccine used in that flock and the STC virulent classic IBDV strain...
- Molecular characterization of the Lactococcus lactis ptsHI operon and analysis of the regulatory role of HPrE J Luesink
Microbial Ingredients Section, NIZO Food Research, 6710 BA Ede, The Netherlands
J Bacteriol 181:764-71. 1999..ptsH and ptsI genes, encoding the general proteins of the phosphoenolpyruvate-dependent phosphotransferase system, HPr and enzyme I, respectively, were cloned, and the regulatory role of HPr was studied by mutational analysis of its ..
- Effects of retinoids on proliferation and plasminogen activator expression in a bovine mammary epithelial cell lineFederica Cheli
Department of Veterinary Science and Technology for Food Safety, University of Milan, Milan, Italy 20134
J Dairy Res 70:367-72. 2003Effects of two natural (retinol and retinoic acid, RA) and one synthetic N-(4-hydroxyphenyl) retinamide (4-HPR) retinoids on proliferation and expression of urokinase-plasminogen activator (u-PA) by bovine mammary epithelial cells were ..
- High-resolution structure of the phosphorylated form of the histidine-containing phosphocarrier protein HPr from Escherichia coli determined by restrained molecular dynamics from NMR-NOE dataN A Van Nuland
Groningen Biomolecular Sciences and Biotechnology Institute, The Netherlands
J Mol Biol 246:180-93. 1995The solution structure of the phosphorylated form of the histidine-containing phosphocarrier protein, HPr, from Escherichia coli has been determined by NMR in combination with restrained molecular dynamics simulations...
- Structural studies of histidine-containing phosphocarrier protein from Enterococcus faecalisM Hahmann
Max Planck Institute for Medical Research, Dept Biophysics, Heidelberg, Germany
Eur J Biochem 252:51-8. 1998..the secondary structure and the local geometry of the active site of histidine-containing phosphocarrier protein (HPr) from Enterococcus faecalis were elucidated...
- The phosphotransferase system (PTS) of Streptomyces coelicolor identification and biochemical analysis of a histidine phosphocarrier protein HPr encoded by the gene ptsHS Parche
Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
Eur J Biochem 265:308-17. 1999b>HPr, the histidine-containing phosphocarrier protein of the bacterial phosphotransferase system (PTS) controls sugar uptake and carbon utilization in low-GC Gram-positive bacteria and in Gram-negative bacteria...
- Quality control for HPLC assay and surrogate end point biomarkers from the fenretinide (4-HPR) breast cancer prevention trialF Formelli
Istituto Nazionale Tumori, Milan, Italy
J Cell Biochem Suppl 34:73-9. 2000The Fenretinide (4-HPR) Breast Cancer Study is a randomized multicenter clinical trial designed to evaluate the effectiveness of the synthetic retinoid 4-HPR, at a dose of 200 mg per os every day for 5 years, in reducing the incidence of ..
- The 1.9 A resolution structure of phospho-serine 46 HPr from Enterococcus faecalisG F Audette
Department of Biochemistry, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5, Canada
J Mol Biol 303:545-53. 2000The histidine-containing phosphocarrier protein HPr is a central component of the phosphoenolpyruvate:sugar phosphotransferase system (PTS), which transfers metabolic carbohydrates across the cell membrane in many bacterial species...
- Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variantsD Gaur
Immunochemistry Laboratory, National Institute of Immunology, Aruna Asaf Ali Road, New Delhi 110067, India
J Biol Chem 276:24978-84. 2001..Human pancreatic ribonuclease (HPR) is structurally and functionally very similar to bovine RNase A and interacts with human RI with a high affinity...
- Loss of catabolite repression function of HPr, the phosphocarrier protein of the bacterial phosphotransferase system, affects expression of the cry4A toxin gene in Bacillus thuringiensis subsp. israelensisSharik R Khan
Centre for Biotechnology, Jawaharlal Nehru University International Centre For Genetic Engineering and Biotechnology, New Delhi, India
J Bacteriol 184:5410-7. 2002b>HPr, the phosphocarrier protein of the bacterial phosphotransferase system, mediates catabolite repression of a number of operons in gram-positive bacteria...
- Regulatory functions of serine-46-phosphorylated HPr in Lactococcus lactisV Monedero
Laboratoire de génétique des microorganismes, INRA CNRS URA 1925, 78850 Thiverval Grignon, France
J Bacteriol 183:3391-8. 2001In most low-G+C gram-positive bacteria, the phosphoryl carrier protein HPr of the phosphoenolpyruvate:sugar phosphotransferase system (PTS) becomes phosphorylated at Ser-46...
- p-Dodecylaminophenol derived from the synthetic retinoid, fenretinide: antitumor efficacy in vitro and in vivo against human prostate cancer and mechanism of actionNoriko Takahashi
Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
Int J Cancer 122:689-98. 2008Fenretinide, N-(4-hydroxyphenyl)retinamide (4-HPR) is an aminophenol-containing synthetic retinoid derivative of all-trans-retinoic acid, which is a potent chemopreventive and antiproliferative agent against various cancers...
- Psychologic aspects of patients participating in a phase I study with the synthetic retinoid 4-hydroxyphenyl retinamideA Filiberti
Terapia del Dolore, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano
Tumori 74:353-6. 1988One hundred and one patients participating in a phase I study with the synthetic retinoid 4-HPR (4-hydroxyphenyl retinamide) were evaluated. The study was set up by Veronesi et al. during 1986 at the National Cancer Institute of Milan...
- Expression of a single gene encoding microbody NAD-malate dehydrogenase during glyoxysome and peroxisome development in cucumberD J Kim
Institute of Cell and Molecular Biology, University of Edinburgh, UK
Plant Mol Biol 26:1833-41. 1994..but then MDH mRNA increases again together with that of peroxisomal NAD(+)-dependent hydroxypyruvate reductase (HPR). The mdh gene is also expressed during cotyledon senescence, together with hpr, icl and ms genes...
- Regulation of the glucose:H+ symporter by metabolite-activated ATP-dependent phosphorylation of HPr in Lactobacillus brevisJ J Ye
Department of Biology, University of California at San Diego, La Jolla 92093 0116
J Bacteriol 176:3484-92. 1994..regulation was shown to be mediated by a metabolite-activated protein kinase that phosphorylase serine 46 in the HPr protein. We have now analyzed the regulation of 2DG uptake and efflux and compared it with that of TMG...
- Identification of methionine-processed HPr in the equine pathogen Streptococcus equiI C Sutcliffe
School of Sciences, University of Sunderland, UK
Syst Appl Microbiol 23:330-2. 2000..equi. N-terminal sequence analysis and Western blotting revealed the protein to be HPr, a central component of the phosphoenolpyruvate:sugar phosphotransferase system (PTS)...
- Bayesian monitoring of a phase 2 chemoprevention trial in high-risk cohorts for prostate cancerH L Weiss
Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
Urology 57:220-3. 2001..A phase 2 chemoprevention trial of 4-hydroxyphenyl retinamide (4-HPR) versus placebo was conducted in men with a histologic diagnosis of early prostate cancer and scheduled to have ..
- Characterization of glucose-repression-resistant mutants of Bacillus subtilis: identification of the glcR geneJ Stülke
Unité de Biochimie Microbienne, Institut Pasteur, Paris, France
Arch Microbiol 175:441-9. 2001..repression (CCR) is mediated by the pleiotropic repressor CcpA and by ATP-dependent phosphorylation of the HPr protein of the phosphotransferase system (PTS)...
- A novel mode of control of Mycoplasma pneumoniae HPr kinase/phosphatase activity reflects its parasitic lifestyleKatrin Steinhauer
Lehrstuhl fur Mikrobiologie, Institut fur Mikrobiologie, Biochemie und Genetik der Friedrich Alexander Universität Erlangen Nürnberg, Staudtstr 5, Germany
Microbiology 148:3277-84. 2002Among the few regulatory proteins encoded by Mycoplasma pneumoniae is HPr kinase/phosphatase (HPrK/P), the key regulator of carbon metabolism in low-GC Gram-positive bacteria...
- Chemopreventive agents induce a senescence-like phenotype in rat mammary tumoursK T Christov
Department of Surgical Oncology, University of Illinois, 840 South Wood Street, Chicago, IL 60612, USA
Eur J Cancer 39:230-9. 2003..MNU)-induced mammary tumours were randomised and treated with tamoxifen, vorozole, 4-(hydroxyphenyl)retinamide (4-HPR), or 9-cis-retinoic acid (9cRA)...
- Biomedical engineering analysis of glass impact injuriesAnthony Sances
Biomechanics Institute Santa Barbara, California 93109, USA
Crit Rev Biomed Eng 30:345-77. 2002..The development, use, and results of high penetration resistance (HPR) laminated glass for windshields are examined...
- An intronic endogenous retrovirus-like sequence attenuates human haptoglobin-related gene expression in an orientation-dependent mannerSeigo Hatada
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Gene 319:55-63. 2003The human haptoglobin-related gene (HPR) gene codes for a haptoglobin-related protein (Hpr), a component of trypanosome lytic factor which circulates in plasma in small quantities...
- Characterization of primate trypanosome lytic factorsElena B Lugli
Department of Medical and Molecular Parasitology, New York University School of Medicine, 341, East 25th Street, New York, NY 10010, USA
Mol Biochem Parasitol 138:9-20. 2004..Haptoglobin-related protein (Hpr) is a unique protein component of TLFs, and its expression has only been demonstrated in humans...
- Streptococci and lactococci synthesize large amounts of HPr(Ser-P)(His~P)Denis J Roy
Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, 2420 Rue de la Terrasse, Quebec City, QC G1V0A6, Canada
Can J Microbiol 54:941-9. 2008b>HPr is a protein of the phosphoenolpyruvate:sugar phosphotransferase transport system (PTS)...
- Protein structure calculation with data imputation: the use of substitute restraintsCarolina Cano
Institut fur Biophysik und Physikalische Biochemie, University of Regensburg, Universitätstr Regensburg, Germany
J Biomol NMR 45:397-411. 2009..tested on three examples: firstly, the Ras-binding domain of Byr2 from Schizosaccharomyces pombe, the mutant HPr (H15A) from Staphylococcus aureus, and a X-ray structure of human ubiquitin...
- The anti-tumor agent, p-DDAP potently suppresses proliferation through apoptosis in human neuroblastoma NB-39-nu cellsNoriko Takahashi
Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
Cancer Lett 297:252-8. 2010..NB-39-nu cells of p-dodecylaminophenol (p-DDAP), a novel derivative of N-(4-hydroxyphenyl) retinamide (4-HPR). p-DDAP suppresses proliferation, and induces G(0)/G(1) arrest and apoptosis to a greater extent than RA and 4-HPR...
- Stability of the high on-treatment platelet reactivity phenotype over time in clopidogrel-treated patientsJuliane Jaitner
Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munchen, Munich, Germany
Thromb Haemost 105:107-12. 2011..In recent studies and ongoing large-scale trials where patients with high on-treatment platelet reactivity (HPR) to clopidogrel are being randomised to an intensified antiplatelet treatment, confirmation of the HPR phenotype is ..
- HOXC8 inhibits androgen receptor signaling in human prostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genesSunshine Daddario Axlund
Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, 12801 E 17th Ave, Aurora, CO 80045, USA
Mol Cancer Res 8:1643-55. 2010..we show that HOXC8 inhibits androgen receptor (AR)-mediated gene induction in LNCaP prostate cancer cells and HPr-1 AR, a nontumorigenic prostate epithelial cell line...
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasmaJohn C Chambers
Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK
Nat Genet 43:1131-8. 2011..surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or ..
- Acetate and propionate impact on the methanogenesis of landfill leachate and the reduction of clogging componentsS Lozecznik
University of Manitoba, Department of Civil Engineering, Winnipeg, Canada MB R3T 5V6
Bioresour Technol 104:37-43. 2012Synthetic leachate with different initial concentrations of acetate (500-2500 mg HAc/L) and propionate (500-3500 mg HPr/L) was treated with active biomass acclimated to landfill leachate under anaerobic mesophilic conditions for 72 h...
- Evaluation of a mucoadhesive fenretinide patch for local intraoral delivery: a strategy to reintroduce fenretinide for oral cancer chemopreventionAndrew S Holpuch
Division of Oral Maxillofacial Surgery, Pathology and Anesthesiology, College of Dentistry, The Ohio State University, 2205 Postle Hall, 305 W 12th Avenue, Columbus, OH 43210 1241, USA
Carcinogenesis 33:1098-105. 2012..65 μM; trace amounts of 4-oxo-4-HPR) and undetectable sera levels...
- Fenretinide (4-HPR): a preventive chance for women at genetic and familial risk?Massimiliano Cazzaniga
Division of Cancer Prevention and Genetics, European Institute of Oncology, 20141 Milan, Italy
J Biomed Biotechnol 2012:172897. 2012..Fenretinide (4-HPR) is the most studied retinoid in breast cancer chemoprevention clinical trials due to its selective accumulation in ..
- Correlation of platelet reactivity and C-reactive protein levels to occurrence of peri-procedural myocardial infarction in patients undergoing percutaneous coronary intervention (from the ARMYDA-CRP study)Giuseppe Patti
Department of Cardiovascular Sciences, Campus Bio Medico University of Rome, Rome, Italy
Am J Cardiol 111:1739-44. 2013The incremental predictive value of high inflammatory status and high on-treatment platelet reactivity (HPR) on the occurrence of periprocedural myocardial infarction (PMI) after percutaneous coronary intervention (PCI) has not been ..
- Mechanism of Trypanosoma brucei gambiense resistance to human serumPierrick Uzureau
Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12 rue des Prof Jeener et Brachet, B 6041 Gosselies, Belgium
Nature 501:430-4. 2013..two serum complexes designated trypanolytic factors (TLF-1 and -2), which both contain haptoglobin-related protein (HPR) and apolipoprotein LI (APOL1)...
- A comparative cohort study on personalised antiplatelet therapy in PCI-treated patients with high on-clopidogrel platelet reactivity. Results of the ISAR-HPR registryK Mayer
Katharina Mayer, MD, Deutsches Herzzentrum Munchen, Lazarettstr 36, 80636 Munich, Germany, Tel 49 89 1218 0, Fax 49 89 1218 4013, E mail
Thromb Haemost 112:342-51. 2014In clopidogrel-treated patients undergoing percutaneous coronary intervention (PCI), high platelet reactivity (HPR) is associated with a higher risk for thrombotic events including stent thrombosis (ST)...
- A New Route for High-Purity Organic Materials: High-Pressure-Ramp-Induced Ultrafast Polymerization of 2-(Hydroxyethyl)MethacrylateE Evlyukhin
Laboratoire de Physique des Lasers LPL, CNRS, Universite Paris 13, Sorbonne Paris Cité, 93430 Villetaneuse, France
Sci Rep 5:18244. 2015..Here, we report a unique process based on a two-step high-pressure ramp (HPR) for the ultrafast and efficient bulk polymerization of 2-(hydroxyethyl)methacrylate (HEMA) at room temperature ..
- HRT dependent performance and bacterial community population of granular hydrogen-producing mixed cultures fed with galactoseGopalakrishnan Kumar
Sustainable Management of Natural Resources and Environment Research Group, Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Viet Nam Department of Environmental Engineering, Daegu University, Gyeongsan, Gyeongbuk 712 714, South Korea
Bioresour Technol 206:188-94. 2016..A peak hydrogen production rate (HPR) of 25...
- [Prevalence of acetylsalicylic acid (ASA) - low response in vascular surgery]T Hummel
Klinik für Gefäßchirurgie, St Josef Hospital, Ruhr Universitat Bochum, Gudrunstraße 56, 44791, Bochum, Deutschland
Chirurg 87:446-54. 2016..Research has revealed that a decreased antiplatelet effect (low response [LR]/high on-treatment platelet reactivity [HPR]) of acetylsalicylic acid (ASA) and clopidogrel is associated with an increased risk of thromboembolic events...
- Kinetic modeling of hydrogen production rate by photoautotrophic cyanobacterium A. variabilis ATCC 29413 as a function of both CO2 concentration and oxygen production rateSiti Fatihah Salleh
a Centre for Renewable Energy, Universiti Tenaga Nasional, Putrajaya Campus, Kajang, Selangor, Malaysia
Prep Biochem Biotechnol . 2016..Haldane's noncompetitive inhibition equation has been modified to determine the specific hydrogen production rate (HPR) as a function of both dissolved CO2 concentration (CTOT) and oxygen production rate (OPR)...
- Assessing fear learning via conditioned respiratory amplitude responsesGiuseppe Castegnetti
Department of Psychiatry, Psychotherapy, and Psychosomatics, University of Zurich, Zurich, Switzerland
Psychophysiology 54:215-223. 2017..Comparing these data with skin conductance responses (SCR) and heart period responses (HPR), we find that, on average, RAR performs similar to SCR in distinguishing CS+ and CS-, but is less sensitive than ..
- Sequence analysis and regulation of the hpr locus, a regulatory gene for protease production and sporulation in Bacillus subtilisM Perego
Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037
J Bacteriol 170:2560-7. 1988The hyperproduction of alkaline and neutral proteases is a phenotype of mutation at the hpr locus. This locus has been cloned and sequenced and has been found to code for a protein of 23,718 Mr...
- The aspartyl replacement of the active site histidine in histidine-containing protein, HPr, of the Escherichia coli Phosphoenolpyruvate:Sugar phosphotransferase system can accept and donate a phosphoryl group. Spontaneous dephosphorylation of acyl-phosphaS Napper
Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
J Biol Chem 274:21776-82. 1999The active site residue, His(15), in histidine-containing protein, HPr, can be replaced by aspartate and still act as a phosphoacceptor and phosphodonor with enzyme I and enzyme IIA(glucose), respectively...
- A common interface on histidine-containing phosphocarrier protein for interaction with its partner proteinsG Wang
Laboratory of Chemical Physics, NIDDK, and the Laboratory of Biochemical Genetics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 275:16401-3. 2000..An important component of this system is the histidine-containing phosphocarrier protein, HPr, which accepts a phosphoryl group from enzyme I, transfers a phosphoryl group to IIA proteins, and is an allosteric ..
- Retinoid therapy of high-risk neuroblastomaC Patrick Reynolds
Division of Hematology Oncology, Children s Hospital of Los Angeles and the University of Southern California Keck School of Medicine, Los Angeles, CA 90054, USA
Cancer Lett 197:185-92. 2003..of vitamin A that include all trans-retinoic acid (ATRA), 13-cis-retinoic acid, (13-cis-RA), and fenretinide (4-HPR)...
- [Inhibitory effects on hepatocarcinoma and B16 melanoma cells by N-(4-hydrophenyl) retinamide]Li Zhang
Department of Biochemistry, Shanghai Medical Celloge, Fudan University, Shanghai 200032
Shi Yan Sheng Wu Xue Bao 36:421-7. 2003In this paper, a significantly effect of N-(4-hydrophenyl) retinamide (4-HPR), a derivative of retinoic acid, was observed on inhibition of migration, invasion, cell growth, and induction of apoptosis in hepatoma cells and B16 melanoma ..
- Glycerol metabolism and PrfA activity in Listeria monocytogenesBiju Joseph
Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Gebäude E1, 97080 Wurzburg, Germany
J Bacteriol 190:5412-30. 2008..Under these conditions, a low level of HPr-Ser-P and a high level of HPr-His-P were present in the cells, suggesting that all enzyme IIA (EIIA) (or EIIB) ..
- N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killingHongtao Wang
Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Mol Cancer Ther 7:2967-76. 2008Fenretinide [N-(4-hydroxyphenyl)retinamide (4-HPR)] is cytotoxic in many cancer cell types. Studies have shown that elevation of ceramide species plays a role in 4-HPR cytotoxicity...
- Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell deathIm Sun Woo
Department of Pharmacology, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, 92 Chilam dong, Jinju 660 751, Republic of Korea
Cancer Lett 276:53-60. 2009..exhibited reduced reactive oxygen species (ROS) generation in response to Bax or N-(4-hydroxyphenyl)retinamide (4-HPR), respectively, which suggests that ROS play a role in the inhibition of cell death by ARF4...
- Transcriptional activator YesS is stimulated by histidine-phosphorylated HPr of the Bacillus subtilis phosphotransferase systemSandrine Poncet
Laboratoire de Microbiologie et Genetique Moleculaire, INRA AgroParisTech CNRS, 78850 Thiverval Grignon, France
J Biol Chem 284:28188-97. 2009In low GC content gram-positive bacteria, the HPr protein is the master regulator of carbon metabolism...
- Cra regulates the cross-talk between the two branches of the phosphoenolpyruvate : phosphotransferase system of Pseudomonas putidaMax Chavarría
Systems Biology Program, Centro Nacional de Biotecnologia, 28049 Cantoblanco Madrid, Spain
Environ Microbiol 15:121-32. 2013..Because FruB (i.e. the EI-HPr-EIIA(Fru) polyprotein) can deliver a high-energy phosphate to the EIIA(Ntr) (PtsN) enzyme of the PTS(Ntr) branch, ..
- Pharmacogenetics of clopidogrelStephen A O'Connor
Institut de Cardiologie, INSERM U 937, Groupe A C T I O N Groupe Hospitalier Pitié Salpêtrière, 47, Boulevard de l Hopital, 75013 Paris, France
Curr Pharm Des 18:5309-27. 2012..leaving up to one third of patients with inadequate platelet inhibition or high on-treatment platelet reactivity (HPR), and subsequent increased ischemic cardiovascular events...
- Antiplatelets in acute coronary syndrome: personal perspectivesRossella Marcucci
Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
Expert Rev Cardiovasc Ther 10:1487-96. 2012High platelet reactivity (HPR) during dual-antiplatelet therapy is a marker of vascular risk, in particular stent thrombosis, in patients with acute coronary syndromes...
- Does the VerifyNow P2Y12 assay overestimate "therapeutic response" to clopidogrel? Insights using short thrombelastographyVikram Khanna
Prof N Curzen, Wessex Cardiothoracic Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, United Kingdom, Tel 44 2380794972, Fax 44 2380795174
Thromb Haemost 111:1150-9. 2014..A higher proportion of individuals had a result indicating high platelet reactivity (HPR) with s-TEG than VN-P2Y12 in (i) 43 clopidogrel naïve volunteers (95.3% vs 81...
- Interaction with enzyme IIBMpo (EIIBMpo) and phosphorylation by phosphorylated EIIBMpo exert antagonistic effects on the transcriptional activator ManR of Listeria monocytogenesArthur Constant Zébré
INRA, Microbiologie de l Alimentation au Service de la Santé Humaine, UMR1319, Jouy en Josas, France AgroParisTech, Microbiologie de l Alimentation au Service de la Santé Humaine, UMR1319, Jouy en Josas, France
J Bacteriol 197:1559-72. 2015..activated via the phosphorylation of His585 in the EIIA(Man)-like domain by the general PTS components enzyme I and HPr. We also show that ManR is regulated by the PTS(Mpo) and that EIIB(Mpo) plays a dual role in ManR regulation...
- PTS-Mediated Regulation of the Transcription Activator MtlR from Different Species: Surprising Differences despite Strong Sequence ConservationPhilippe Joyet
INRA, Microbiologie de l Alimentation au service de la Santé Humaine MICALIS, UMR1319, Jouy en Josas, France
J Mol Microbiol Biotechnol 25:94-105. 2015..casei MtlR is not phosphorylated by Enzyme I (EI) and HPr. When the corresponding His in PRD2 of MtlR from B. subtilis and G...
- A Potential Role of Flag Leaf Potassium in Conferring Tolerance to Drought-Induced Leaf Senescence in BarleySeyed A Hosseini
Molecular Plant Nutrition Group, Physiology and Cell Biology, Leibniz Institute of Plant Genetics and Crop Plant Research Gatersleben, Germany
Front Plant Sci 7:206. 2016..Relative to the drought-sensitive line LPR, the line HPR retained more K in its flag leaves under low K supply and showed delayed flag leaf senescence under terminal ..
- Mannitol-specific phosphoenolpyruvate-dependent phosphotransferase system of Enterococcus faecalis: molecular cloning and nucleotide sequences of the enzyme IIIMtl gene and the mannitol-1-phosphate dehydrogenase gene, expression in Escherichia coli, and cR Fischer
Ruhr Universitat Bochum, Gebäude NDEF, Bochum, Federal Republic of Germany
J Bacteriol 173:3709-15. 1991..It is phosphorylated in a reaction sequence requiring enzyme I and heat-stable phosphocarrier protein (HPr)...
- The transition state regulator Hpr of Bacillus subtilis is a DNA-binding proteinP T Kallio
Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, La Jolla, California 92037
J Biol Chem 266:13411-7. 1991..One of these regulators is the product of the hpr gene, first identified by mutations affecting the synthesis of extracellular proteases...
- Physiological consequences of the complete loss of phosphoryl-transfer proteins HPr and FPr of the phosphoenolpyruvate:sugar phosphotransferase system and analysis of fructose (fru) operon expression in Salmonella typhimuriumD A Feldheim
Department of Biology, University of California, San Diego, La Jolla 92093
J Bacteriol 172:5459-69. 1990..Other experiments indicated that sugar uptake via the PTS can utilize either FPr-P or HPr-P as the phosphoryl donor, but that FPr is preferred for fructose uptake whereas HPr is preferred for uptake of the ..
- Sugar transport by the bacterial phosphotransferase system. Molecular cloning and structural analysis of the Escherichia coli ptsH, ptsI, and crr genesD W Saffen
Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218
J Biol Chem 262:16241-53. 1987..These genes encode three cytoplasmic proteins of the phosphoenol-pyruvate:glycose phosphotransferase system: HPr, Enzyme I, and IIIGlc, respectively...
- Cloning and characterization of the Bacillus subtilis prkA gene encoding a novel serine protein kinaseC Fischer
Institut de Biologie et Chimie des Proteines, CNRS, Lyon, France
Gene 168:55-60. 1996..An Escherichia coli strain, LBG1605, carrying a mutated ptsH gene (encoding HPr (His-containing protein) of the bacterial phosphotransferase system (PTS)) and complemented for PTS activity with ..
- Mutation of serine-46 to aspartate in the histidine-containing protein of Escherichia coli mimics the inactivation by phosphorylation of serine-46 in HPrs from gram-positive bacteriaS Napper
Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada
Biochemistry 35:11260-7. 1996Histidine-containing protein (HPr) is a phosphocarrier protein of the bacterial phosphoenolpyruvate:sugar phosphotransferase system...
- Energetic implications for protein phosphorylation. Conformational stability of HPr variants that mimic phosphorylated formsM E Huffine
Department of Medical Biochemistry, Texas A and M University, College Station, Texas 77843, USA
J Biol Chem 271:28898-902. 1996The HPr protein from Bacillus subtilis is a key protein in the phosphoenolpyruvate-sugar transport system. HPr has two biological phosphorylation sites...
- The structure of enzyme IIAlactose from Lactococcus lactis reveals a new fold and points to possible interactions of a multicomponent systemP Sliz
Department of Biochemistry, University of Toronto, ON, Canada
Structure 5:775-88. 1997..The PTS consists of two non-specific energy coupling components, enzyme I and a heat stable phosphocarrier protein (HPr), as well as several sugar-specific multiprotein permeases known as enzymes II...
- Arsenic Trioxide and Acute Myeloid LeukemiaYongkui Jing; Fiscal Year: 2012..results show that a combination of therapeutically achievable concentration of As2O3 with fenretinide (4-HPR), a retinoid approved for clinical trials, synergizes in causing apoptosis in AML cells which express detectable (..
- Novel L-threo-sphinganines for ceramides-based cancer therapyBarry J Maurer; Fiscal Year: 2012..to act as synergizing agents for the dihydroceramide-increasing, cytotoxic retinoid, fenretinide (4-HPR). Ceramides are sphingolipids with pro- death signaling properties...
- A Phase I trial combining fenretinide and safingol to target overproduction of diCHARLES PATRICK REYNOLDS; Fiscal Year: 2012..Maurer, MD PhD ABSTRACT Fenretinide (4-HPR) is a p53-independent retinoid selectively cytotoxic to cancer cells via increase of reactive oxygen species and ..
- DIFFERENTIATION AND APOPTOSIS IN MALIGNANT NEUROBLASTOMASwapan Ray; Fiscal Year: 2009..all-trans-retinoic acid (ATRA), 13-cis-retinoicacid (13-CRA), and fenretinide [N-(4-hydroxyphenyl) retinamide or 4-HPR] induce differentiation in 5 human neuroblastoma cell lines (SH-SY5Y, SK-N-BE2, SK-N-DZ, IMR-32, and SK-N-MC)...
- TAMOXIFEN AND RETINOIC ACID EFFECT ON THE UTERUSKenneth Nephew; Fiscal Year: 2000..We will carry out a detailed analysis of the molecular effects of tamoxifen and 4-HPR (fenretinide; a retinoic acid derivative) on the uterine endometrium...
- PREDICTION AND MODIFICATION OF MELANOMA RISKDuPont Guerry; Fiscal Year: 2000..Project 2 utilizes a randomized trial of topical tretinoin and 4-HPR (fenretinide) to test chemoprevention in another cohort with dysplastic nevi...
- Correlative trial of fenretinide against GlioblastomasVINAY PUDUVALLI; Fiscal Year: 2003..induces apoptosis in tumor tissue and correlate the degree of apoptosis with serum and tissue concentrations of 4-HPR and with clinical efficacy...
- PHASE III STUDY OF FENRETINIDE IN BLADDER CARCINOFENESISScott Lippman; Fiscal Year: 2001..We propose a phase III clinical trial of fenretinide (4-HPR), to be of intermediate duration (15 months) and size (160 evaluable patients), in preventing superficial bladder ..
- TRANSLATIONAL RESEARCH IN BREAST CANCERBeth Overmoyer; Fiscal Year: 2004..This study will also determine if 4-HPR therapy induces in vivo expression of TIG3, a novel gene involved with apoptosis, in treated patients, and confirm ..
- Parenteral Formulations for Synthetic RetinoidsEarle Holsapple; Fiscal Year: 2005..the lead product, develop a documented manufacturing process that could be implemented in a sterile product facility in Phase 3, and understand the physiological and pharmacological principles that govern tissue distribution of HPR.
- Novel Ceramide-based Chemotherapy for Acute LeukemiaBarry Maurer; Fiscal Year: 2007..We reported that fenretinide (4-HPR) increased de novo ceramide synthesis in cancer cell lines in vitro, and inhibitors of ceramide catabolism, such as ..
- RETINOID THERAPY OF NEUROBLASTOMACharles Reynolds; Fiscal Year: 2000..We discovered that the RA derivative N-(4-hydroxyphenyl) retinamide (fenretinide; 4-HPR) is highly cytotoxic for NBL cell lines that are resistant to 13-cis-RA...
- IGF-I MODULATION BY 4-HPR AND BREAST CANCER RISKUmberto Veronesi; Fiscal Year: 1999..aged less that 50 years, on intervention with the synthetic retinoid 4-(hydroxyphenyl) retinamide (fenretinide or 4-HPR)...
- PHOSPHOENOLPYRUVATE: GLYCOSE PHOSPHOTRANSFERASE SYSTEMSaul Roseman; Fiscal Year: 2004..The P-transfer sequence is via 4 proteins: PEP <-> Enzyme I (EI) <-> HPr <-> IIAGlc (or IIIGlc) <-> IICBGlc -> Glc...
- Stephen L Hajduk; Fiscal Year: 2014..contains apolipoprotein A-1 (apoA-1), a protein found in all HDLs, and two primate specific proteins, haptoglobin related protein (Hpr) and apolipoprotein L-1 (apoL-1)...
- Samuel A Shelburne; Fiscal Year: 2015..sites in conjunction with its co-factor histidine-containing phosphoprotein phosphorylated at serine residue 46 (HPr-Ser46-P)...
- GENETIC DISSECTION OF PROGESTERONE RECEPTOR FUNCTIONDonald McDonnell; Fiscal Year: 2004..with the discovery that this receptor can exist in either of two functionally-distinct forms within target cells: hPR-A and hPR-B...
- PLASMA PROTEINS: MARKERS OF CHEMICAL EXPOSUREGHULAM ANSARI; Fiscal Year: 1991..be selected to participate in a two-year chemoprevention clinical trial in which they will be administered either 4-HPR or a placebo and monitored at 6 month intervals with OFIA and Pap cytology...
- ANALOG STUDIES OF 4-HPR AND ITS GLUCURONIDERobert W Curley; Fiscal Year: 2013..The synthetic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR) shows some unique activity as a breast cancer chemopreventive with further reduced toxicity and teratogenicity...
- Origin of Virulence Factors in African TrypanosomesANDREW MCARTHUR; Fiscal Year: 2004..The active component of TLF is the primate specific haptoglobin related protein (HPR). This protein is the sole factor preventing infection of humans by T. b...
- PHYSIOLOGIC CHARACTERISTICS OF TREPONEMA PALLIDUMSteven Norris; Fiscal Year: 2004..A unique aspect of the T. pallidum genome i that it encodes HPr (PtsH), the HPr(ser) kinase (PtsK), a frameshifted Enzyme I (PtsI) and two additiona potential regulatory PTS ..
- MDA-7/IL-24 and free radicals in renal cancer therapyPaul Dent; Fiscal Year: 2009..Additionally, we will prove or refute whether [arsenic trioxide (As2O3) and N-(4-hydroxyphenyl) retinamide (4-HPR)], agents that generate reactive oxygen species, enhance the ability of low GST-MDA-7 concentrations (0.5-1...
- Mitochondrial GRHPR and HyperoxaluriaScott Cramer; Fiscal Year: 2006..that catalyzes conversion of glyoxylate to glycolate (GR), conversion of hydroxypyruvate to D-glycerate (HPR), and conversion of D-glycerate to hydroxypyruvate (DGDH)...
- 'IN VITRO SCREENING OF SELECTED CHEMOPREVENTIVE AGENTS UDavid McCormick; Fiscal Year: 2000..Four chemopreventive compounds belonging to the class of antiproliferative agents, 4 HPR, DFMO, Sulindac, and Perillyl Alcohol are being used at five doses in a nontoxic range...
- HISTORY AND CONTROL OF THE HAPTOGLOBIN GENE CLUSTERNobuyo Maeda; Fiscal Year: 1999..will test whether or not the retrovirus- like sequence in the first intron of the human haptoglobin related gene (HPR) is, as we have hypothesized, responsible for inactivation of this gene...
- LOW DOSE TAMOXIFEN AND 4HPR IN EARLY BREAST CANCERAndrea Decensi; Fiscal Year: 2000..aim of the present project is the search for an interaction between low-dose tamoxifen and the synthetic retinoid 4-HPR on a set of surrogate endpoint biomarkers (SEBs) in premenopausal women with in situ or minimally invasive breast ..
- HIERARCHY OF PROTEIN FOLDING AND STABILITYJ Scholtz; Fiscal Year: 1999..The HPr protein from bacteria is an ideal vehicle for those studies since the proteins from both Escherichia coli and ..
- BRUCE A MC CLANE; Fiscal Year: 2016..isolates is dn a mobilizable transposon, and determining whether two component regulatory systems and/or the exponential growth phase repressor Hpr play a role in regulating the sporulation-associated expression of CPE.
- TARGETING CERAMIDE METABOLISM FOR CANCER TREATMENTMyles Cabot; Fiscal Year: 2003..synthase (GCS), will be exposed to conventional chemotherapy, Adriamycin, Taxol, N-4(hydroxyphenyl)retinamide(4-HPR) in the absence or presence of agents that retard ceramide glycosylation, the latter being evaluated through ..
- REGULATION OF HEPATIC RETINOL METABOLISMA Ross; Fiscal Year: 2000..hormone, retinoic acid (RA) and well as by exogenous, synthetic retinoids such as 4-(N-hydroxyphenyl) retinamide (4-HPR)...
- UPSTREAM ACTIVATION OF BACILLUS PROMOTERSJAMES HOCH; Fiscal Year: 1990..The regulatory genes, sacU, sacQ, prtR, and hpr pleiotropically affect the synthesis of several enzymes including levansucrase, sacB, and alkaline protease, aprE...
- Secreted Proteins as Breast Cancer Prevention MarkersMichael Gould; Fiscal Year: 2007..Drugs to be used include: the monoterpene Perillyl alcohol; the retinoids 9-cis retinoic acid (or Targretin) and 4-HPR; the COX-2 inhibitor Celecoxib; and an EGFR kinase inhibitor...
- ANTI-TUMOR ACTIVITY OF GLUCARATE AND HPRThomas Webb; Fiscal Year: 1993..e. ineffective) doses, synergistically with other agents such as N-(4-hydroxyphenyl)retinamide (HPR) to inhibit tumor growth and in fact cause tumor shrinkage. When given p.o...
- Xenograft models of human neuroblastoma bone metastases.Charles Reynolds; Fiscal Year: 2004..We anticipate that this project will increase our understanding of the biology of bone metastases and will develop mouse models for pre-clinical testing of new therapeutic approaches to high risk neuroblastoma. ..
- Whole genome amplification and DNA pooling strategiesImmaculata DeVivo; Fiscal Year: 2004..Results from the pooling experiments will determine whether this method may be sensitive enough for use in nested case-control studies where a small difference in allele frequency is expected. ..
- Regulation of Pulmonary Vascular Tone During CirrhosisCHRYSTELLE GARAT CARTER; Fiscal Year: 2004..This project will not only define the cellular basis for hepatopulmonary syndrome, but will also contribute to our understanding of how pulmonary vascular tone is controlled at the most basic level. ..
- Regulation of Vascular Tone During CirrhosisETHAN CARTER; Fiscal Year: 2003..This project will not only define the cellular basis for hepatopulmonary syndrome, but will also contribute to our understanding of how pulmonary vascular tone is controlled at the most basic level. ..
- Structural studies on the P1 plasmid partition apparatusMaria Schumacher; Fiscal Year: 2009....
- Structural mechanism of DNA segregation by the pSK41 par systemMaria Schumacher; Fiscal Year: 2010..Thus, understanding the structural basis for DNA segregation by this par system will provide several points of potential therapeutic intervention against pSK41 harboring multidrug resistant S. aureus strains. ..
- Structural studies on the Initiator protein, IBP39.Maria Schumacher; Fiscal Year: 2008..vaginalis suggests it is a possible target for the treatment of trichomoniasis, which afflicts over 170 million individuals each _,ear, ..
- ROLE OF MISMATCH REPAIR IN SPORADIC TUMOR SUPPRESSIONGuo Min Li; Fiscal Year: 2004..This study will not only provide insight into the etiology of sporadic bladder cancers, but also lead to the identification of novel mismatch repair components. ..
- Role of Oxidants & Angiogenesis in Kaposi's SarcomaSusan Mallery; Fiscal Year: 2007..Elucidation of these interactions will not only clarify KS pathogenic mechanisms, but will also identify sites for KS therapeutic intervention. ..
- Formulation & Evaluation of Bioadhesive Gels for Oral Cancer ChemopreventionSusan Mallery; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Mechanism of PCNA-dependent 5'->3' Mismatch ExcisionGuo Min Li; Fiscal Year: 2010..g., the EXO1 gene, are associated with cancer development, identifying the components required for the novel 5'excision pathway will provide new diagnostic markers for HNPCC and other MMR deficient cancer syndromes. ..
- Chemoprevention of Oral Dysplasia by Black RaspberriesSusan Mallery; Fiscal Year: 2005..This experimental design (comparison of pretreatment and post-treatments tissues) permits each patient to serve as their own internal control. ..
- Identifying Proteins Involved in DNA Damage ResponseGuo Min Li; Fiscal Year: 2005..Because certain cancer chemotherapeutics, e.g., cisplatin and alkylating agents, can signal apoptosis in an MMR-dependent fashion, this study will also impact cancer treatment, particularly cancers caused by MMR defects. ..
- Dissection and Reconstitution of Human Mismatch RepairGuo Min Li; Fiscal Year: 2009..abstract_text> ..
- Case-Control Study of Pancreas Cancer Etiologic FactorsHarvey Risch; Fiscal Year: 2008..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. [unreadable] [unreadable]..
- Amplification of Custom RNA in PlantsSERGEI KAZAKOV; Fiscal Year: 2002..Our current business strategy is to sell custom RNA in partnership with Large Scale Biology Corp. and license the technology to certain other manufacturers. ..
- Library-based selection of optimal gene inhibitorsSERGEI KAZAKOV; Fiscal Year: 2003..In this way, optimized Lassos will be derived in an automatic and straightforward manner for application as agents for target validation, gene function analysis, and therapeutics. ..
- LOCAL AND LONG RANGE INTERACTIONS IN PROTEIN FOLDINGJ Scholtz; Fiscal Year: 2004..abstract_text> ..
- Apoptotic effect of zinc in targeting prostate cancerPei Feng; Fiscal Year: 2009..The elucidation of the molecular basis of the cell specific response to zinc restoration in prostate cancer cells will contribute to the development of new approaches to the treatment of prostate cancer. ..
- Multiplexed mRNA quanitification using self-circularizing RNA probesSERGEI KAZAKOV; Fiscal Year: 2008..This system will be particularly useful for RNAi-based drugs that are currently in development for several disorders, including HCV, where the ability to monitor target knock-down and off-target effects is important. [unreadable]..
- P27Kipl deficiency, potential promoter of carcinogenesisKonstantin Christov Tzelkov; Fiscal Year: 2003..abstract_text> ..
- 2nd International Cervical Cancer ConferenceMichele Follen; Fiscal Year: 2002..Each session chair and speaker has been chosen based on his/her publications, funding and national reputation. ..
- CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGYHarvey Risch; Fiscal Year: 2002....
- DNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDYHarvey Risch; Fiscal Year: 2002..abstract_text> ..
- A new method for multiplex detection of micro-RNAs (miR-ID)SERGEI KAZAKOV; Fiscal Year: 2008..The method of micro-RNA detection has novel features that promise better sensitivity and selectivity than other micro-RNA assays currently available. [unreadable] [unreadable] [unreadable] [unreadable]..
- Mechanism of SHeA2 Action in Ovarian CancerDoris Benbrook; Fiscal Year: 2009..The elucidation of the proteins involved in the SHetA2 pathwayswill provide potential biomarkers for ovarian cancer diagnosis, prevention and treatment strategies. ..
- Rexinoid Synergy in Prostate Cancer ApoptosisMarcia Dawson; Fiscal Year: 2009..We anticipate that our results will provide a more effective and less systemically toxic means of enhancing the efficacy of chemotherapeutic agents currently used to treat prostate cancer. ..
- In Vitro Cancer Prevention Biomarker DevelopmentEugene Elmore; Fiscal Year: 2004..Using cluster analysis, we will determine the global gene expression changes induced by each agent. The strength of the proposed approach lies in the high quality data that has already determined from the HEC Assay. ..
- Brain tumor angiogenesis: Integrin ceramide signalingAnat Erdreich Epstein; Fiscal Year: 2008..abstract_text> ..
- Influence of genotype on urinary oxalate excretionCARLA MONICO; Fiscal Year: 2007..enzymes (alanine:glyoxylate aminotransferase or AGT in PHI, and glyoxylate:hydroxypyruvate reductase or GR/HPR in PHII) but clinically relevant correlations between genotype and phenotype are currently lacking...
- Ceramide in angiogenic integrin signalingAnat Erdreich Epstein; Fiscal Year: 2006....
- PPMP as a Ceramide Catabolism Inhibitor for ChemotherapyBarry Maurer; Fiscal Year: 2003..of ceremide catabolism, in order to enhance the anti-cancer activity of the cytotoxic retinoid, fenretinide (4-HPR)...
- Cell Biology of Human Thiamine TransportersVEEDAMALI SUBRAMANIAN; Fiscal Year: 2005....
- Directed Libraries of Self-Circularizing Antisense RNASERGEI KAZAKOV; Fiscal Year: 2004..They should find diverse applications, includinginhibitingthe expression of disease-related genes, functional genomics, and target validation. ..
- Steroids and Stem Cell in CarcinogenesisDoris Benbrook; Fiscal Year: 2004..This research will enhance our understanding of the process of carcinogenesis and chemoprevention, which could ultimately translate into strategies and pharmaceuticals for prevention of cancer. ..
- ATP-DEPENDENT PROTEIN KINASES IN GRAM-POSITIVE BACTERIAMilton Saier; Fiscal Year: 2004..our model organism, by phosphorylating seryl residue-46 in the paralogous phosphocarrier proteins of the PTS, HPr (the major co-repressor present in all low G+C Gram-positive bacteria) and Crh (the minor co-repressor present only ..