Genomes and Genes
Gene Symbol: IGF2BP2
Description: insulin like growth factor 2 mRNA binding protein 2
Alias: IMP-2, IMP2, VICKZ2, insulin-like growth factor 2 mRNA-binding protein 2, IGF-II mRNA-binding protein 2, IGF2 mRNA-binding protein 2, VICKZ family member 2
Publications234 found, 100 shown here
- TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexesC Gamper
Laboratory of Molecular Immunology, Columbia University, New York, NY 10032, USA
Mol Immunol 37:73-84. 2000..The finding that TRAF-3 binds p62, suggests that TRAF-3 may serve as an adapter molecule at the nuclear membrane, in addition to its known adapter function at the plasma membrane...
- Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam StudyMatthias B Schulze
Public Health Nutrition Unit, Technische Universitat Munchen, Freising, Germany
Diabetes Care 32:2116-9. 2009..We investigated whether metabolic biomarkers and single nucleotide polymorphisms (SNPs) improve diabetes prediction beyond age, anthropometry, and lifestyle risk factors...
- Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohortJie Wen
Department of Endocrinology, Shanghai Medical College Fudan University, Shanghai, China
PLoS ONE 5:e9153. 2010..In the present study, we evaluated the influence of 17 genetic variants from 15 candidate loci, identified in type 2 diabetes GWASs and the metaanalysis, in a Han Chinese cohort...
- Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clampsLeen M 't Hart
Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
Diabetes 59:287-92. 2010..In this study, we have investigated the combined effects of eight known beta-cell loci on insulin secretion stimulated by three different secretagogues during hyperglycemic clamps...
- Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in KoreaEun Seok Kang
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
Transplantation 88:693-8. 2009..Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea...
- Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, TexasE J Parra
Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, ON, Canada, L5L 1C6
Diabetologia 54:2038-46. 2011..The top signals observed in this meta-analysis were followed up in the Diabetes Genetics Replication and Meta-analysis Consortium (DIAGRAM) and DIAGRAM+ datasets...
- Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in menLu Qi
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 89:1453-8. 2009..A widely held hypothesis is that interactions between genetic predisposition and Western-type lifestyle contribute to the epidemic of type 2 diabetes (T2D). No study has tested this hypothesis...
- Underlying genetic models of inheritance in established type 2 diabetes associationsGeorgia Salanti
Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
Am J Epidemiol 170:537-45. 2009..Information on the genetic model of robustly replicated association signals derived from genome-wide association studies may be useful for predictive modeling and for designing biologic and functional experiments...
- Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the associationKazuaki Miyake
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
J Hum Genet 54:236-41. 2009..We then selected 11 genes, KCNQ1, TCF7L2, CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, HHEX, GCKR, HNF1B, KCNJ11 and PPARG, whose associations with diabetes have already been reported and ..
- Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMIJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Diabetes 59:751-5. 2010..Our goal was to investigate if any type 2 diabetes variants uncovered through genome-wide association studies (GWAS) impact BMI in childhood...
- Association analysis of type 2 diabetes Loci in type 1 diabetesHui Qi Qu
Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
Diabetes 57:1983-6. 2008To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L.
- Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2Jan R Brants
Laboratory for Molecular Oncology, Department of Human Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology VIB, Herestraat 49, B 3000 Leuven, Belgium
FEBS Lett 569:277-83. 2004..We found that the insulin-like growth factor II mRNA-binding protein 2 gene (IMP2), but not its family members IMP1 and IMP3, was robustly downregulated in mutant E12.5 embryos...
- VICKZ proteins: a multi-talented family of regulatory RNA-binding proteinsJoel K Yisraeli
Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, POB 12272, Jerusalem, Israel 91120
Biol Cell 97:87-96. 2005..Such a 'post-transcriptional operon' model, as proposed by Keene and Tenenbaum [(2002) Mol. Cell 9, 1161-1167], can explain the differential, integrated action of multiple RNA-binding proteins on mRNA targets...
- HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaBIsabelle Cleynen
Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Herestraat 49, Box 602, B 3000 Leuven, Belgium
Mol Cancer Res 5:363-72. 2007b>IMP2 (insulin-like growth factor-II mRNA binding protein 2) is an oncofetal protein that is aberrantly expressed in several types of cancer...
- Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levelsRicha Saxena
Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
Science 316:1331-6. 2007..and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome ..
- A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variantsLaura J Scott
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
Science 316:1341-5. 2007..intergenic region of chromosome 11p12, contribute to the identification of T2D-associated variants near the genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, ..
- Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetesEleftheria Zeggini
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
Science 316:1336-41. 2007..We detected diabetes susceptibility loci in and around the genes CDKAL1, CDKN2A/CDKN2B, and IGF2BP2 and confirmed the recently described associations at HHEX/IDE and SLC30A8...
- Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell functionLaura Pascoe
Diabetes Research Group, Newcastle University, Newcastle upon Tyne, UK
Diabetes 56:3101-4. 2007..studies have identified common, novel type 2 diabetes susceptibility loci within the FTO, CDKAL1, CDKN2A/CDKN2B, IGF2BP2, HHEX/IDE, and SLC30A8 gene regions...
- Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studiesNiels Grarup
Steno Diabetes Center, Niels Steensens Vej 1, NLC2 14, 2820 Gentofte, Denmark
Diabetes 56:3105-11. 2007..in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant...
- Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese populationM Horikoshi
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Diabetologia 50:2461-6. 2007..kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B) and insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2), which had not been in the list of functional candidates...
- Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese populationShintaro Omori
Laboratory for Diabetic Nephropathy, SNP Research Center, RIKEN, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
Diabetes 57:791-5. 2008....
- Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12qF Takeuchi
Department of Medical Ecology and Informatics, Research Institute, International Medical Center of Japan, Tokyo, Japan
J Hum Genet 53:314-24. 2008..79 (P=0.001). No significant association was found for known candidate gene loci on 3q, such as ADIPOQ and IGF2BP2. Using the available samples, we have observed disease associations of SNPs derived from two novel gene loci in ..
- Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetesEleftheria Zeggini
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Nat Genet 40:638-45. 2008..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
- Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French CaucasiansKonsta Duesing
Section of Genomic Medicine, Imperial College London, Hammersmith Campus, London, U K
Diabetes 57:1992-6. 2008We performed a comprehensive genetic association study of common variation spanning the IGF2BP2 locus in order to replicate the association of the "confirmed" type 2 diabetes susceptibility variants rs4402960 and rs1470579 in the French ..
- Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studiesJoshua P Lewis
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Diabetes 57:2220-5. 2008..Our objective was to examine the influence of type 2 diabetes genes identified in whole-genome association studies in a large African American case-control population...
- Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 AsiansMaggie C Y Ng
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
Diabetes 57:2226-33. 2008..However, the implications of these genes in Asians are unclear...
- Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes riskHana Lango
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
Diabetes 57:3129-35. 2008..Here, we assess the ability of 18 confirmed type 2 diabetes variants to differentiate between type 2 diabetic case and control subjects...
- Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant riskDharambir K Sanghera
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
BMC Med Genet 9:59. 2008..proliferator-activated receptor gamma 2 (PPARG2; rs 1801282); insulin-like growth factor two binding protein 2 (IGF2BP2; rs 4402960); cyclin-dependent kinase 5, a regulatory subunit-associated protein1-like 1 (CDK5; rs7754840); a ..
- Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clampsM J Groenewoud
Department of Molecular Cell Biology, Leiden University Medical Center LUMC, P O Box 9600, 2300 RC, Leiden, The Netherlands
Diabetologia 51:1659-63. 2008..Genome-wide association studies have recently identified novel type 2 diabetes susceptibility gene regions. We assessed the effects of six of these regions on insulin secretion as determined by a hyperglycaemic clamp...
- Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han populationYing Wu
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
Diabetes 57:2834-42. 2008Genome-wide association studies have identified common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, HHEX/IDE, EXT2, and LOC387761 loci that significantly increase the risk of type 2 diabetes...
- Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based studyMandy van Hoek
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Diabetes 57:3122-8. 2008..Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 diabetes in the general population is unclear...
- SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populationsHiroyuki Unoki
Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa 230 0045, Japan
Nat Genet 40:1098-102. 2008..5 x 10(-3); OR = 1.14, rs2237897, P = 2.4 x 10(-4); OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 x 10(-11); OR = 1.24, rs2237897, P = 1.2 x 10(-4); OR = 1.36)...
- Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk allelesL Pascoe
The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Diabetologia 51:1989-92. 2008..The aim of this study was to test the cumulative effects of diabetes-risk alleles on measures of beta cell function in non-diabetic individuals...
- Common type 2 diabetes risk gene variants associate with gestational diabetesJeannet Lauenborg
Center for Pregnant Women with Diabetes, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
J Clin Endocrinol Metab 94:145-50. 2009..We aimed to examine the association between gestational diabetes mellitus (GDM) and 11 recently identified type 2 diabetes susceptibility loci...
- Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima IndiansRong Rong
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 58:478-88. 2009In recent genome-wide association studies, variants in CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, CDKN2B, LOC387761, and FTO were associated with risk for type 2 diabetes in Caucasians...
- Genotype score in addition to common risk factors for prediction of type 2 diabetesJames B Meigs
General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
N Engl J Med 359:2208-19. 2008..We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone...
- Clinical risk factors, DNA variants, and the development of type 2 diabetesValeriya Lyssenko
Department of Clinical Sciences, Lund University, Malmo, Sweden
N Engl J Med 359:2220-32. 2008..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
- Replication study of candidate genes associated with type 2 diabetes based on genome-wide screeningYasuharu Tabara
Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
Diabetes 58:493-8. 2009..A total of 11 previously reported single-nucleotide polymorphisms (SNPs) from the TCF7L2, CDKAL1, HHEX, IGF2BP2, CDKN2A/B, SLC30A8, and KCNJ11 genes were analyzed.
- Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studiesStephanie May Ruchat
Department of Preventive Medicine, Laval University, Quebec City, QC, Canada
Acta Diabetol 46:217-26. 2009..We analysed 23 SNPs in 9 T2DM genes (CDKAL1, CDKN2B, HHEX/IDE, IGF2BP2, KCNJ11, SLC30A8, TCF2, TCF7L2 and WFS1) in a maximum of 712 men and women from the Quebec Family Study...
- Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus StudyX Lin
Discovery Analytics, GlaxoSmithKline, Collegeville, PA, USA
Diabetologia 52:600-8. 2009....
- Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican AmericansXia Li
Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine of USC, Los Angeles, California, USA
Obesity (Silver Spring) 17:729-36. 2009Genome-wide association studies showed variation in insulin-like growth factor-2 binding protein 2 (IGF2BP2) to be associated with type 2 diabetes mellitus (T2DM)...
- Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetesN Pulizzi
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Diabetologia 52:825-9. 2009..of this study was to investigate whether there is an interaction between birthweight and common variants in the TCF7L2, HHEX, PPARG, KCNJ11, SLC30A8, IGF2BP2, CDKAL1, CDKN2A/2B and JAZF1 genes in the risk of developing type 2 diabetes.
- Type 2 diabetes risk alleles are associated with reduced size at birthRachel M Freathy
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
Diabetes 58:1428-33. 2009..We tested whether common genetic variants that predispose to type 2 diabetes also reduce birth weight...
- Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolismMandy van Hoek
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Diabetes 58:1440-4. 2009..We investigated the effects of such well-studied polymorphisms and their interactions with fetal malnutrition on type 2 diabetes risk and related phenotypes in the Dutch Famine Birth Cohort...
- Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese populationFumihiko Takeuchi
Department of Medical Ecology and Informatics, Research Institute, International Medical Center of Japan, Tokyo, Japan
Diabetes 58:1690-9. 2009..To identify novel type 2 diabetes gene variants and confirm previously identified ones, a three-staged genome-wide association study was performed in the Japanese population...
- Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish menAlena Stancakova
Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
Diabetes 58:2129-36. 2009..We investigated the effects of 18 confirmed type 2 diabetes risk single nucleotide polymorphisms (SNPs) on insulin sensitivity, insulin secretion, and conversion of proinsulin to insulin...
- Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight geneJianhua Zhao
Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Diabetes 58:2414-8. 2009..In order to investigate whether type 2 diabetes risk-conferring alleles associate with low birth weight in our Caucasian childhood cohort, we examined the effects of 20 such loci on this trait...
- PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese populationCheng Hu
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
PLoS ONE 4:e7643. 2009..In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism...
- Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in SingaporeJonathan T Tan
Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
J Clin Endocrinol Metab 95:390-7. 2010..However, the association in other East Asian populations is less well characterized...
- Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypesStephanie May Ruchat
Department of Preventive Medicine, Laval University, Quebec, Canada
J Nutrigenet Nutrigenomics 2:225-34. 2009..The objective of this study was to test the hypothesis that the associations between single nucleotide polymorphisms (SNPs) in these genes and adiposity and glucose homeostasis-related phenotypes are influenced by dietary fat intake...
- Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 IndiansGanesh Chauhan
Functional Genomics Unit, Institute of Genomics and Integrative Biology CSIR, Delhi, India
Diabetes 59:2068-74. 2010Common variants in PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 genes have been shown to be associated with type 2 diabetes in European populations by genome-wide association studies...
- Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese populationXueyao Han
Department of Endocrinology and Metabolism, Peking University People s Hospital, Peking University Diabetes Center, no 11, XiZhiMen South Street, Beijing, China
BMC Med Genet 11:81. 2010..association studies have identified many novel genetic loci for type 2 diabetes (T2D); among these genes, CDKAL1, IGF2BP2, SLC30A8, CDKN2A/B, HHEX, FTO, TCF2, KCNQ1, and WFS1 are the most important...
- Replication of recently described type 2 diabetes gene variants in a South Indian populationManickam Chidambaram
Department of Molecular Genetics, Madras Diabetes Research Foundation ICMR Advanced Centre for Genomics of Diabetes, Chennai 603103, India
Metabolism 59:1760-6. 2010..003) of the CDKN2A/B gene, rs7923837 (P = .038) of the HHEX gene, and rs12056034 (P = .033) of the BAZ1B gene were associated with T2D in our population. Large-scale studies are needed in our population to validate our findings...
- Association between IGF2BP2 rs4402960 polymorphism and risk of type 2 diabetes mellitus: a meta-analysisHongxia Jia
Department of Endocrinology and Metabolism, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
Arch Med Res 42:361-7. 2011Genome-wide association studies recently found IGF2BP2 rs4402960 polymorphism associated with enhanced risk of type 2 diabetes mellitus (T2DM). Numerous studies have been published to replicate the association...
- Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes riskJie Wu
Department of Endocrinology, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai 200433, People s Republic of China
Acta Diabetol 49:S87-97. 2012..This meta-analysis demonstrated that these two common polymorphisms is a risk factor for developing T2D, but these associations vary in different ethnic populations...
- Two isoforms of the mRNA binding protein IGF2BP2 are generated by alternative translational initiationHang T T Le
University of Cambridge Metabolic Research Laboratories and Department of Clinical Biochemistry, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, United Kingdom
PLoS ONE 7:e33140. 2012b>IGF2BP2 is a member of a family of mRNA binding proteins that, collectively, have been shown to bind to several different mRNAs in mammalian cells, including one of the mRNAs encoding insulin-like growth factor-2...
- IGF2BP2 and IGF2 genetic effects in diabetes and diabetic nephropathyTianwei Gu
Department of Molecular Medicine and Surgery, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
J Diabetes Complications 26:393-8. 2012The IGF2BP2 gene is located on chromosome 3q27.2 within a region linked to type 1 diabetes (T1D), type 2 diabetes (T2D) and diabetic nephropathy (DN). Its protein functionally binds to 5'-UTR of the imprinting IGF2 gene...
- The rs11705701 G>A polymorphism of IGF2BP2 is associated with IGF2BP2 mRNA and protein levels in the visceral adipose tissue - a link to type 2 diabetes susceptibilityDimitry A Chistiakov
Pirogov Russian State Medical University, 117997 Moscow, Russia
Rev Diabet Stud 9:112-22. 2012Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) regulates translation of IGF2, a growth factor that plays a key role in controlling fetal growth and organogenesis including adipogenesis and pancreatic development...
- Replication of association study between type 2 diabetes mellitus and IGF2BP2 in Han Chinese populationSi Min Zhang
Department of Endocrinology and Metabolism, Peking University People s Hospital, Peking University Diabetes Center, Beijing 100044, China
Chin Med J (Engl) 126:4013-8. 2013The association between IGF2BP2 and type 2 diabetes mellitus (T2DM) has been repeatedly confirmed among different ethnic populations...
- A family of insulin-like growth factor II mRNA-binding proteins represses translation in late developmentJ Nielsen
RNA Regulation Centre, Institute of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
Mol Cell Biol 19:1262-70. 1999..The results imply that cytoplasmic 5' UTR-binding proteins control IGF-II biosynthesis during late mammalian development...
- Autoantibodies to IGF-II mRNA binding protein p62 and overexpression of p62 in human hepatocellular carcinomaJianying Zhang
Department of Molecular and Experimental Medicine, W M Keck Autoimmune Disease Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Autoimmun Rev 1:146-53. 2002....
- Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancerNiels A Hammer
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Reproduction 130:203-12. 2005Insulin-like growth factor-II mRNA-binding proteins 1, 2 and 3 (IMP1, IMP2 and IMP3) belong to a family of RNA-binding proteins implicated in mRNA localization, turnover and translational control...
- Replication of genome-wide association studies of type 2 diabetes susceptibility in JapanYukio Horikawa
Department of Diabetes and Endocrinology, Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan
J Clin Endocrinol Metab 93:3136-41. 2008..and populations of European origin, several groups have recently identified novel type 2 diabetes susceptibility genes, including FTO, SLC30A8, HHEX, CDKAL1, CDKN2B, and IGF2BP2, none of which were in the list of functional candidates.
- Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention programAllan F Moore
Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Diabetes 57:2503-10. 2008....
- Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean populationY M Cho
Department of Internal Medicine, College of Medicine, Seoul National University, 28 Yongon dong Chongno gu, Seoul 110 744, Korea
Diabetologia 52:253-61. 2009..The aim of the present study was to examine the association between these diabetogenic variants and gestational diabetes mellitus (GDM)...
- Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort studyPhilippa J Talmud
Centre of Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF
BMJ 340:b4838. 2010....
- IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetesS Rodriguez
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Growth Horm IGF Res 20:310-8. 2010Genetic variation at the insulin-like binding protein 2 (IGF2BP2) gene has been associated with type 2 diabetes (T2D) by genome-wide association studies and by replication analyses...
- A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinomaJ Y Zhang
W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Exp Med 189:1101-10. 1999..However, the possible involvement of p62 autoantigen as a factor in the transformation process remains to be elucidated...
- Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean populationYong Ho Lee
Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon dong Seodaemun gu, Seoul 120 752, South Korea
J Hum Genet 53:991-8. 2008..aim of the present study was to investigate the association among the polymorphisms of SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1 and KCNQ1 and the risk of T2DM in the Korean population...
- The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivityAxel Haupt
Medical Clinic, Department of Endocrinology, Metabolism, Nephrology and Angiology, Otfried Muller Strasse 10, 72076 Tubingen, Germany
J Clin Endocrinol Metab 94:1775-80. 2009..We assessed whether the risk alleles in TCF7L2, CDKAL1, HHEX, SLC30A8, IGF2BP2, CDKN2A/2B, JAZF1, and WFS1 reduce insulin secretion in an additive manner and whether their impact is influenced ..
- Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family StudyS M Ruchat
Department of Social and Preventive Medicine, PEPS Laval University, 2300 rue de Terrasse, Quebec, QC, Canada G1V 0A6
Diabetologia 53:679-89. 2010....
- Type 2 diabetes susceptibility loci in the Ashkenazi Jewish populationMichal Bronstein
Department of Genetics, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel
Hum Genet 124:101-4. 2008..Our study, however, strongly supports the robustness of WGA studies for the identification of genes affecting complex traits in general and T2D in particular...
- Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studiesC Herder
Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Centre at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
Horm Metab Res 40:722-6. 2008..30-1.39, p-values 0.0008-0.0004]. In addition, we found evidence for association of SNPs in the genes PPARG, IGF2BP2, HHEX, TCF7L2, and FTO with type 2 diabetes in the same directions as previously described (p<0...
- Leptospiral proteins recognized during the humoral immune response to leptospirosis in humansH Guerreiro
, Oswaldo Cruz Foundation, Brazilian Ministry of Health, 40295-001, Brazil
Infect Immun 69:4958-68. 2001..These findings indicate that leptospiral proteins recognized during natural infection are potentially useful for serodiagnosis and may serve as targets for vaccine design...
- Long-range atmospheric transport of three toxaphene congeners across Europe. Modeling by chained single-box FATEMOD programJaakko Paasivirta
Department of Chemistry, University of Jyvaskyla, P O Box 35, 40014, Jyvaskyla, Finland
Environ Sci Pollut Res Int 16:191-205. 2009..Polychlorobornanes analyzed in biota of the Barents Sea offered one case to study this modeling alternative, while toxaphene has been and partly still is used massively at southern East Europe and around rivers flowing to the Aral Sea...
- Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein importP Percipalle
MRC Laboratory of Molecular Biology, Cambridge, England
J Mol Biol 266:722-32. 1997..Our results are consistent with models for nuclear protein import in which Ran nucleotide exchange modulates the binding of the importin-substrate complexes during translocation through nuclear pore complexes...
- Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptorM Reedijk
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
Mol Cell Biol 10:5601-8. 1990..The interaction between the CSF-1 receptor and PI 3'-kinase may contribute to c-fms fibroblast transformation and play a role in CSF-1-stimulated macrophages...
- Numerous FUS-positive inclusions in an elderly woman with motor neuron diseaseYukio Fujita
Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
Neuropathology 31:170-6. 2011..Therefore, we consider that the age of onset and clinical features of FUS-related disorders may be variable...
- The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-SrcK Neet
Graduate Program in Neurosciences, University of California, San Diego, La Jolla 92093, USA
Mol Cell Biol 15:4908-20. 1995..Our results suggest that GAP-A.p62 may function as a docking protein and may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation...
- Development of local connections in ferret somatosensory cortexS L Juliano
Department of Anatomy and Cell Biology, USUHS, Bethesda, Maryland 20814, USA
J Comp Neurol 374:259-77. 1996..This study of the development of the somatosensory cortex confirms the ubiquitous nature of column-like connections throughout the neocortex and provides a novel view of the radial nature of early neocortical maturation...
- p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositisAnna Nogalska
Department of Neurology, USC Neuromuscular Center, Good Samaritan Hospital, University of Southern California Keck School of Medicine, Los Angeles, CA 90017 1912, USA
Acta Neuropathol 118:407-13. 2009....
- Function and assembly of nuclear pore complex proteinsK Bodoor
Department of Cell Biology and Anatomy, University of Calgary, AB, Canada
Biochem Cell Biol 77:321-9. 1999..These findings support a model in which it is POM121 rather than gp210 that defines initial membrane-associated NPC assembly intermediates and which may therefore represent an essential component of the central framework of the NPC...
- PCR typing of genetic determinants for metallo-beta-lactamases and integrases carried by gram-negative bacteria isolated in Japan, with focus on the class 3 integronNaohiro Shibata
Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan
J Clin Microbiol 41:5407-13. 2003..In the present study, it was confirmed that strains carrying bla(IMP-1) with a class 1 integron are the most prevalent type in Japan, although several intI3 carriers have also been identified sporadically in this country...
- The CREB-binding protein (CBP) cooperates with the serum response factor for transactivation of the c-fos serum response elementS Ramirez
Laboratoire Oncogenese, Differenciation et Transduction du Signal, CNRS UPR 9079, Institut Fédératif sur le Cancer, 7 rue Guy Moquet, 94801 Villejuif, France
J Biol Chem 272:31016-21. 1997....
- Mitosis and inhibition of intracellular transport stimulate palmitoylation of a 62-kD proteinD I Mundy
Imperial Cancer Research Fund, London, United Kingdom
J Cell Biol 116:135-46. 1992..We suggest that the acylation and deacylation of p62 may be important in vesicular transport and that this process may be regulated during mitosis...
- Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factorJ Tang
The Ben May Institute for Cancer Research and the Department of Pharmacological and Physiological Sciences, The University of Chicago, Illinois 60637, USA
Oncogene 15:1823-32. 1997..This study suggests that the GAP-associated p62 acts as an SH2 domain docking protein and mediates the interaction between Nck and EGF receptor in response to EGF stimulation...
- Group II intron reverse transcriptase in yeast mitochondria. Stabilization and regulation of reverse transcriptase activity by the intron RNAS Zimmerly
Departments of Molecular Genetics and Biochemistry, The Ohio State University, Columbus, OH, 43210, USA
J Mol Biol 289:473-90. 1999..Together, our results show that binding to intron-containing RNAs stabilizes and regulates the activity of p62...
- Furin processing and proteolytic activation of Semliki Forest virusXinyong Zhang
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Virol 77:2981-9. 2003..However, the in vivo infectivity of mutant L was more strongly inhibited than that of wt/p62, due to additional effects of the mutation on virus-cell binding...
- Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistryMaria Pikkarainen
Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University Hospital, Kuopio, Finland
J Neuropathol Exp Neurol 67:280-98. 2008....
- Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assemblyP Grandi
Biochemie Zentrum Heidelberg BZH, University of Heidelberg, Germany
Mol Biol Cell 8:2017-38. 1997....
- Mutations that promote furin-independent growth of Semliki Forest virus affect p62-E1 interactions and membrane fusionXinyong Zhang
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Virology 327:287-96. 2004..Sequence analysis of the pci mutants identified mutations primarily on the E2 protein, and suggested sites important in the interaction of p62 with E1 and the regulation of fusion...
- Bergmann glial S100B activates myo-inositol monophosphatase 1 and Co-localizes to purkinje cell vacuoles in SCA1 transgenic miceParminder J S Vig
Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, USA
Cerebellum 8:231-44. 2009..This may cause BG-PC interface to degenerate resulting in vacuolar formation. In sum, these data indicate that vacuoles appearing early in SCA1 PCs could be developing through some unknown autophagic mechanism...
- p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagySerhiy Pankiv
Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
J Biol Chem 282:24131-45. 2007..In fact, p62 bodies and these structures are indistinguishable. Taken together, our results clearly suggest that p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy...
- Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organizationM Carmo-Fonseca
European Molecular Biology Laboratory, Heidelberg Federal Republic of Germany
Eur J Cell Biol 55:17-30. 1991....
- Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62L E Marengere
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
J Biol Chem 267:22779-86. 1992..Loss-of-function and gain-of-function mutations in the GAP SH2 domains can therefore be used to identify residues that are critical for receptor and p62 binding...
- The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidantsJ Y Masson
Centre hospitalier de l Universite Laval, Health and Environment, Quebec, Canada
Mol Cell Biol 16:2091-100. 1996..A DNA clone containing the IMP2 gene that complemented the most sensitive bleomycin mutant was identified...
- Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteinsT Hu
Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA
J Cell Biol 134:589-601. 1996..These data support a model in which the p62 complex binds to a multicomponent particle consisting of transport ligand and cytosolic factors to achieve accumulation of ligand near the central gated channel of the nuclear pore complex...
- Expression of ubiquitin-binding protein p62 in ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis with dementia: analysis of five autopsy cases with broad clinicopathological spectrumToshiya Nakano
Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, 36 1 Nishi cho, 683 8504, Yonago, Japan
Acta Neuropathol 107:359-64. 2004..Since p62 is believed to have a neuroprotective role, the formation of these inclusions may represent a non-harmful, rather protective effect against the neuronal degeneration in ALSD...
- Sequestosome 1: mutation frequencies, haplotypes, and phenotypes in familial Paget's disease of boneJean Morissette
Centre de recherche en endocrinologie moléculaire et oncologique, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Quebec, Canada
J Bone Miner Res 21:P38-44. 2006..The P392L mutation was the most prevalent, embedded in two different haplotypes, possibly shared by other populations. We also examined the phenotype and penetrance of P392L...
- In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62Conny Stumptner
Institute of Pathology, Medical University of Graz, Graz, Austria
Hepatology 46:851-60. 2007....
- Interaction of the transcription factor Sp1 with the nuclear pore protein p62 requires the C-terminal domain of p62I Han
Department of Medicine, University of Alabama at Birmingham 35294, USA
J Cell Biochem 68:50-61. 1998..We propose that this interaction of a nuclear pore protein with Sp1 may reflect the nuclear organization required to bring transcribable DNA in contact with the transcription factors...
- Mechanisms of Ubiquitin Trafficking in NeuronsMichael C Wooten; Fiscal Year: 2013....
- Role of p62 in Protein Aggregation and Neurodegeneration in ALSHaining Zhu; Fiscal Year: 2009..Purchase of necessary equipment, supplies and reagents for the proposed research will also stimulate the economy as intended by the American Recovery &Reinvestment Act. ..
- Arunabh Bhattacharya; Fiscal Year: 2014..abstract_text> ..
- Junichi Sadoshima; Fiscal Year: 2014..The knowledge obtained from this study may lead to better understanding of the mechanism of myocardial injury and heart failure and the development of novel strategies to treat patients with myocardial infarction and cardiomyopathy. ..
- Wei Xing Zong; Fiscal Year: 2016..At the clinical level, it may establish LC3 or SCCA1 as a molecular signature for suggesting treatment with proteotoxic agents. ..
- Brendan Cormack; Fiscal Year: 2014..Deletions of the Ssn2/Ssn3/Ssn8/Srb8 module of Mediator results in a 10-fold increase in virulence, and deletion of Imp2', a poorly understood regulator of stress genes in S. cerevisiae, profoundly decreases virulence in C...
- Joseph Avruch; Fiscal Year: 2016..Among them is an RNA binding protein IMP2, first discovered by its ability to bind to an IGF2 mRNA expressed primarily in fetal life, whose translation is ..
- AIDS Opportunistic Infections: Virulence of C. glabrataBrendan Cormack; Fiscal Year: 2009..Deletions of the Ssn2/Ssn3/Ssn8/Srb8 module of Mediator results in an 10x increase in virulence, and deletion of Imp2', a poorly understood regulator of stress genes in S. cerevisiae, profoundly decreases (100x) virulence in C...
- REGULATION OF HEPATIC INSULIN EXTRACTIONKenneth S Polonsky; Fiscal Year: 2013..We propose to study the T2DM-associated genes KCNJ11, TCF7L2, KCNQ1, CDKAL1, IGF2BP2 and SLC30A8 since it appears that diabetes-associated variants in these genes increase T2DM risk by decreasing ..
- Molecular mechanism underlying Frontotemporal Lobar RegenerationDavid Medina; Fiscal Year: 2013..Successful completion of these proposed studies will represent a significant contribution to the field, and the data obtained has the potential to identify novel therapeutic targets in the fight against FTLD and TDP-43 proteinopathies. ..
- Autophagy and human islet amyloid polypeptide in animal models of type 2 diabetesJacqueline Rivera; Fiscal Year: 2013....
- Stephen B Howell; Fiscal Year: 2014....
- Steven M Lipkin; Fiscal Year: 2015..The overall goal of this project is to understand the mechanism of Agr2-/- intestinal epithelia, macrophage and abnormal host microflora interaction to cause multinucleate giant cells, granulomas, ileitis and colitis. ..
- Rhea M Sumpter; Fiscal Year: 2014....
- A Phase 0 Trial of Hydroxychloroquine in Patients with Stage III and IV ResectablJanice Mehnert; Fiscal Year: 2010..Our hope is that we will be able to use these results to better understand and detect autophagy, making it easier to develop future drugs against this pathway in cancer. ..
- Michael Karin; Fiscal Year: 2016..The completion of these studies will result in a much better understanding of the molecular etiology of PanCa and may lead to new strategies for blocking the progression of precursor lesions to invasive PDAC. ..
- Margaret Kielian; Fiscal Year: 2016..We will define the novel mechanisms that protect the RuV fusion protein from low pH inactivation during virus biogenesis. ..
- Function of intramembrane aspartic proteaseEvgeny I Rogaev; Fiscal Year: 2012..We plan to provide evidence for the essential role of this protein in CNS development and signaling in neurulation, which if disrupted, underlies anencephaly, a most common congenital brain defect in humans. ..
- The role of phosphorylation of Ulk1 by GSK-3b in myocardial autophagy and agingPeiyong Zhai; Fiscal Year: 2013..abstract_text> ..
- Loss-of-function mechanisms in Huntington's DiseaseScott O Zeitlin; Fiscal Year: 2013..We propose experiments that will help us to understand how the mutation affects htt normal function so that we can discover new therapeutic strategies based on restoring htt function in people affected with HD. ..
- Autophagy, p62 and the Nrf2 Intersect to Protect Against Tau ToxicityGail V W Johnson; Fiscal Year: 2013..2. That the Nrf2 pathway plays a role in facilitating the degradation of pathological forms of tau. 3. That activation of the Nrf2 or autophagy pathway results in increased survival of cells that express pathological forms of tau. ..
- Joanna C Bakowska; Fiscal Year: 2016....
- P62, Protein Aggregation and Fatty Liver DiseaseMartin Obin; Fiscal Year: 2005..Data obtained will be directed to the prevention and treatment of NASH and other age- associated protein aggregation diseases. ..
- Obesity-induced inflammation and insulin resistance by the p62/PKCzeta signalingJorge Moscat; Fiscal Year: 2012....
- Elizabeth P Henske; Fiscal Year: 2016....
- Edward M Campbell; Fiscal Year: 2015..Understanding the mechanisms by which TRIM5alpha mediates its antiviral effects could allow this knowledge to be harnessed in the form of antiviral therapy for people infected with HIV-1 ..
- The p62/atypical PKC signaling complex in Th2 differentiation and asthmaJorge Moscat; Fiscal Year: 2012....
- Role and mechanism of action of p62/Sqstm1 in Ras-induced tumorigenesis in lungJorge Moscat; Fiscal Year: 2013..abstract_text> ..
- Sonia Caprio; Fiscal Year: 2014..examine the relationships between a panel of 16 gene variants (TCF7L2, PPARG, FTO, KCNJ11, NOTCH2, WFS1, CDKAL1, IGF2BP2, SLC30A8, JAZF1, HHEX, CDC123/CAMK1D, WFS1, TSPAN8/LGR5, THADA, ADAMTS9) and measures of beta-cell function in ..
- Eric H Baehrecke; Fiscal Year: 2015..The importance of Atg6/Beclin1 and the Vps34 regulatory complex in all normal cells and in cancer illustrate the significance of these studies. ..
- GTP BINDING PROTEINS AND INSULIN RECEPTOR SINGNALINGCHIN SUNG; Fiscal Year: 1999..These proposed studies therefore should provide new insights into IR signaling mechanisms in target cells. ..
- STRUCTURE/FUNCTION OF THE TRANS GOLGI NETWORKKathryn Howell; Fiscal Year: 2002..Together, the data obtained using diverse approaches will help us reach our ultimate goal of understanding the structure function of the trans-Golgi and the molecular details of the process of secretion. ..
- ANTIBODIES AND ANTIGENS IN HEPATOCELLULAR CARCINOMAENG TAN; Fiscal Year: 2005..Other studies are to determine the target genes(s) of SG2NA and potential protein binding partners. Elucidation of the properties and function of these proteins might contribute to understanding co-activating factors in carcinogenesis. ..
- MECHANISM & CONTROL OF HUMAN NUCLEOTIDE EXCISION REPAIRZhen Qiang Pan; Fiscal Year: 2001....
- Selective Inhibitors of SRC Family Kinases in NeoplasiaTHOMAS SMITHGALL; Fiscal Year: 2002..Combined with the in vitro assays, we hope to identify novel inhibitory activities that target specific Src kinase isoforms and oncogenic signaling pathways. ..
- BREAST CANCER GROWTH SUPPRESSOR GENEGraham Casey; Fiscal Year: 2001..One of these candidates may be the human homologue of IMP2, a mitochondrial intermembrane signal peptidase believed to be important in the induction of apoptosis...
- MUTANT p62 AND THE ROLE OF THE BONE MICROENVIRONMENT IN PAGET'S DISEASEJOLENE WINDLE; Fiscal Year: 2009..The proposed studies should lead to a better understanding of PD, and may therefore facilitate the development of improved therapeutic approaches. ..
- Mechanism of M. tuberculosis Phagosome Maturation ArrestVojo Deretic; Fiscal Year: 2008..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
- Hyperacidification and Pseudomonas infections in CFVojo Deretic; Fiscal Year: 2006..abstract_text> ..
- Pseudomonas in Cystic Fibrosis-Regulation of MucoidyVojo Deretic; Fiscal Year: 2006..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
- Autophagy in TuberculosisVOJO P DERETIC; Fiscal Year: 2011..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
- PREDOCTORAL FELLOWSHIPS FOR STUDENTS WITH DISABILITIESROBERT RAINEY; Fiscal Year: 2006..I will undertake complementation studies to determine if IMMP2L will function in place of the yeast homolog, IMP2. Results of this project may lead to developing effective treatments to combat neural diseases caused by defects in ..
- INHIBITION OF OSTEOCLAST ACTIVITY BY OIP-1/HSCALSAKAMURI REDDY; Fiscal Year: 2008..abstract_text> ..
- Promoting Islet Transplantation with Synthetic ScaffoldsWILLIAM LOWE; Fiscal Year: 2004..abstract_text> ..
- NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEMKenneth Hensley; Fiscal Year: 2005..abstract_text> ..
- Replication of GWAS for Maternal Glycemia, Birthweight and their InteractionWILLIAM LOWE; Fiscal Year: 2009....
- PDX-1 Expression and Embryonic Stem CellsWILLIAM LOWE; Fiscal Year: 2004..Thus, the proposed studies will address novel ways of promoting the differentiation of ES cells into islets with the ultimate goal of enhancing islet cell transplantation. ..
- HYPERGLYCEMIA AND VASCULAR CELL SIGNALINGWILLIAM LOWE; Fiscal Year: 2001..Identifying the signaling pathways that mediate the effects of hyperglycemia on vascular cell function is critical to devising means to prevent these changes and their complications, such as atherosclerosis. ..
- Diabetes Genes: Maternal Glycemia and Birth WeightWILLIAM LOWE; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- The Progesterone Receptor Gene and Ovarian Cancer RiskCELESTE PEARCE; Fiscal Year: 2005..We will also test our previous two case-control studies for any additional identified SNPs, including 326 cases and 493 controls (many of the SNPs have already been tested in these populations). ..
- Role of EGFR in Viral Infected Lung Epithelial CellsMartha M Monick; Fiscal Year: 2010..Completion of these studies will add to our understanding of mechanisms of RSV infection of airway epithelium and the role of targeted signaling pathways in the subsequent inflammation and life span of infected cells. ..
- DEVELOPMENTAL ASPECTS OF OSTEOCLAST FORMATION IN VITROG Roodman; Fiscal Year: 2005....
- "Nicotine: Potential therapies and possible pitfalls"Russell Brown; Fiscal Year: 2004..Additionally, we plan a final roundtable discussion with all speakers to discuss the commonalities of the positive effects, underlying mechanisms, and adverse effects of nicotine as a potential therapy. ..
- Relationship of Apo B and BHMT: Nutrition and PhysiologyJanet Sparks; Fiscal Year: 2004..A potential link of two pathways whose products or intermediates are associated with increased cardiovascular disease risk could be established. ..
- Role of Acetaldehyde in Alcoholic CardiomyopathyJun Ren; Fiscal Year: 2008..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
- Program Project Grant-Pathobiology of Paget's DiseaseG Roodman; Fiscal Year: 2007..The knowledge gained from this P01 grant will offer important insights for normal bone cell biology especially for understanding the paracrine regulation of osteoblasts by OCLs. ..
- Molecular Analysis of Human Breast CancerRobert Clarke; Fiscal Year: 2007..AIM 4: We will use tissue arrays (multiple cores from archival tissues arrayed on glass slides) to validate and optimize the performance of these classifiers in a retrospective prognostic study of human breast tumors. ..
- ESTROGEN INDUCED PROGRESSION IN BREAST CANCERRobert Clarke; Fiscal Year: 2001....
- Mechanisms of Ataxin-1 Mediated Purkinje Cell DeathPARMINDER VIG; Fiscal Year: 2007..Further, changes observed in SCA-1 patients and in transgenic mice will be compared with that in Machado-Joseph disease/SCA-3, other cerebellar ataxias and normal controls. ..
- PATHOBIOLOGY OF THE OSTEOCLAST IN PAGETS DISEASEG Roodman; Fiscal Year: 2002..abstract_text> ..
- IGF-1, Oxidative Stress and Cardiovascular AgingJun Ren; Fiscal Year: 2002..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
- LRRK2 Proteomics: Kinase/GTPase Hypothesis and Interaction PartnersZhenyu Yue; Fiscal Year: 2007..It will also reveal roles of LRRK2 in regulating or interacting with other molecular pathways. This proposal will provide valuable information for PD therapeutic design directed towards enzymatic activity of LRRK2. [unreadable]..
- Signals for Commitment to Radiation Induces ApoptosisAlexandru Almasan; Fiscal Year: 2007..unreadable] [unreadable]..
- Prognostic Models in Diffuse Large B-Cell LymphomaIzidore S Lossos; Fiscal Year: 2010..Further, establishment of a paraffin-based RNA prognostic model using the new methodology of RNA extraction could serve as a paradigm for other lymphomas and tumors. ..
- Phenotype-Genotype Interactions and Type 2 DiabetesJames Meigs; Fiscal Year: 2005..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
- OSTEOCLASTS FROM TRANSGENIC MICEG Roodman; Fiscal Year: 2009..Our long-term goal will be to characterize the role of ADAM8/a9b1 in the bone destruction which accompanies collagen induced arthritis, which will be started in grant year 5. ..
- Ovarian Cancer and Gonadotropin SignalingCELESTE PEARCE; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Paget's Disease of Bone/Dysplasia:Advances/ChallengesG Roodman; Fiscal Year: 2006..to become aware of the effectiveness of the various drugs that can be used to treat the two disorders; 5.) to understand the role of surgery in managing the two disorders. ..
- Hepatic Steatosis Modulation by Apo B Gene TranscriptionJANET DEHOFF SPARKS; Fiscal Year: 2010....
- A Pooled Analysis to Identify New Ovarian Cancer Risk FactorsCeleste Leigh Pearce; Fiscal Year: 2010..Gaining a better understanding of ovarian cancer, which this project will provide, is critical to identifying women at risk and for improving the outcome for women who are diagnosed with this disease. ..