IGF2BP2

Summary

Gene Symbol: IGF2BP2
Description: insulin like growth factor 2 mRNA binding protein 2
Alias: IMP-2, IMP2, VICKZ2, insulin-like growth factor 2 mRNA-binding protein 2, IGF-II mRNA-binding protein 2, IGF2 mRNA-binding protein 2, VICKZ family member 2
Species: human

Top Publications

  1. ncbi TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes
    C Gamper
    Laboratory of Molecular Immunology, Columbia University, New York, NY 10032, USA
    Mol Immunol 37:73-84. 2000
  2. pmc Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study
    Matthias B Schulze
    Public Health Nutrition Unit, Technische Universitat Munchen, Freising, Germany
    Diabetes Care 32:2116-9. 2009
  3. pmc Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort
    Jie Wen
    Department of Endocrinology, Shanghai Medical College Fudan University, Shanghai, China
    PLoS ONE 5:e9153. 2010
  4. pmc Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps
    Leen M 't Hart
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 59:287-92. 2010
  5. doi Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea
    Eun Seok Kang
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
    Transplantation 88:693-8. 2009
  6. pmc Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas
    E J Parra
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, ON, Canada, L5L 1C6
    Diabetologia 54:2038-46. 2011
  7. pmc Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 89:1453-8. 2009
  8. pmc Underlying genetic models of inheritance in established type 2 diabetes associations
    Georgia Salanti
    Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
    Am J Epidemiol 170:537-45. 2009
  9. pmc Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 59:751-5. 2010
  10. pmc Association analysis of type 2 diabetes Loci in type 1 diabetes
    Hui Qi Qu
    Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1983-6. 2008

Research Grants

  1. Mechanisms of Ubiquitin Trafficking in Neurons
    Michael C Wooten; Fiscal Year: 2013
  2. Arunabh Bhattacharya; Fiscal Year: 2014
  3. Role of p62 in Protein Aggregation and Neurodegeneration in ALS
    Haining Zhu; Fiscal Year: 2009
  4. Wei Xing Zong; Fiscal Year: 2016
  5. Junichi Sadoshima; Fiscal Year: 2014
  6. Brendan Cormack; Fiscal Year: 2014
  7. Joseph Avruch; Fiscal Year: 2016
  8. AIDS Opportunistic Infections: Virulence of C. glabrata
    Brendan Cormack; Fiscal Year: 2009
  9. REGULATION OF HEPATIC INSULIN EXTRACTION
    Kenneth S Polonsky; Fiscal Year: 2013
  10. Molecular mechanism underlying Frontotemporal Lobar Regeneration
    David Medina; Fiscal Year: 2013

Detail Information

Publications237 found, 100 shown here

  1. ncbi TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes
    C Gamper
    Laboratory of Molecular Immunology, Columbia University, New York, NY 10032, USA
    Mol Immunol 37:73-84. 2000
    ..The finding that TRAF-3 binds p62, suggests that TRAF-3 may serve as an adapter molecule at the nuclear membrane, in addition to its known adapter function at the plasma membrane...
  2. pmc Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study
    Matthias B Schulze
    Public Health Nutrition Unit, Technische Universitat Munchen, Freising, Germany
    Diabetes Care 32:2116-9. 2009
    ..We investigated whether metabolic biomarkers and single nucleotide polymorphisms (SNPs) improve diabetes prediction beyond age, anthropometry, and lifestyle risk factors...
  3. pmc Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort
    Jie Wen
    Department of Endocrinology, Shanghai Medical College Fudan University, Shanghai, China
    PLoS ONE 5:e9153. 2010
    ..In the present study, we evaluated the influence of 17 genetic variants from 15 candidate loci, identified in type 2 diabetes GWASs and the metaanalysis, in a Han Chinese cohort...
  4. pmc Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps
    Leen M 't Hart
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 59:287-92. 2010
    ..In this study, we have investigated the combined effects of eight known beta-cell loci on insulin secretion stimulated by three different secretagogues during hyperglycemic clamps...
  5. doi Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea
    Eun Seok Kang
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
    Transplantation 88:693-8. 2009
    ..Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea...
  6. pmc Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas
    E J Parra
    Department of Anthropology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, ON, Canada, L5L 1C6
    Diabetologia 54:2038-46. 2011
    ..The top signals observed in this meta-analysis were followed up in the Diabetes Genetics Replication and Meta-analysis Consortium (DIAGRAM) and DIAGRAM+ datasets...
  7. pmc Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 89:1453-8. 2009
    ..A widely held hypothesis is that interactions between genetic predisposition and Western-type lifestyle contribute to the epidemic of type 2 diabetes (T2D). No study has tested this hypothesis...
  8. pmc Underlying genetic models of inheritance in established type 2 diabetes associations
    Georgia Salanti
    Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
    Am J Epidemiol 170:537-45. 2009
    ..Information on the genetic model of robustly replicated association signals derived from genome-wide association studies may be useful for predictive modeling and for designing biologic and functional experiments...
  9. pmc Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 59:751-5. 2010
    ..Our goal was to investigate if any type 2 diabetes variants uncovered through genome-wide association studies (GWAS) impact BMI in childhood...
  10. pmc Association analysis of type 2 diabetes Loci in type 1 diabetes
    Hui Qi Qu
    Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1983-6. 2008
    To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L.
  11. ncbi Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2
    Jan R Brants
    Laboratory for Molecular Oncology, Department of Human Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology VIB, Herestraat 49, B 3000 Leuven, Belgium
    FEBS Lett 569:277-83. 2004
    ..We found that the insulin-like growth factor II mRNA-binding protein 2 gene (IMP2), but not its family members IMP1 and IMP3, was robustly downregulated in mutant E12.5 embryos...
  12. ncbi VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins
    Joel K Yisraeli
    Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School, POB 12272, Jerusalem, Israel 91120
    Biol Cell 97:87-96. 2005
    ..Such a 'post-transcriptional operon' model, as proposed by Keene and Tenenbaum [(2002) Mol. Cell 9, 1161-1167], can explain the differential, integrated action of multiple RNA-binding proteins on mRNA targets...
  13. ncbi HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB
    Isabelle Cleynen
    Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Herestraat 49, Box 602, B 3000 Leuven, Belgium
    Mol Cancer Res 5:363-72. 2007
    b>IMP2 (insulin-like growth factor-II mRNA binding protein 2) is an oncofetal protein that is aberrantly expressed in several types of cancer...
  14. ncbi Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
    Science 316:1331-6. 2007
    ..and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome ..
  15. pmc A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Science 316:1341-5. 2007
    ..intergenic region of chromosome 11p12, contribute to the identification of T2D-associated variants near the genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, ..
  16. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..We detected diabetes susceptibility loci in and around the genes CDKAL1, CDKN2A/CDKN2B, and IGF2BP2 and confirmed the recently described associations at HHEX/IDE and SLC30A8...
  17. ncbi Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function
    Laura Pascoe
    Diabetes Research Group, Newcastle University, Newcastle upon Tyne, UK
    Diabetes 56:3101-4. 2007
    ..studies have identified common, novel type 2 diabetes susceptibility loci within the FTO, CDKAL1, CDKN2A/CDKN2B, IGF2BP2, HHEX/IDE, and SLC30A8 gene regions...
  18. ncbi Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies
    Niels Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 14, 2820 Gentofte, Denmark
    Diabetes 56:3105-11. 2007
    ..in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant...
  19. ncbi Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population
    M Horikoshi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabetologia 50:2461-6. 2007
    ..kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B) and insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2), which had not been in the list of functional candidates...
  20. ncbi Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population
    Shintaro Omori
    Laboratory for Diabetic Nephropathy, SNP Research Center, RIKEN, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Diabetes 57:791-5. 2008
    ....
  21. doi Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q
    F Takeuchi
    Department of Medical Ecology and Informatics, Research Institute, International Medical Center of Japan, Tokyo, Japan
    J Hum Genet 53:314-24. 2008
    ..79 (P=0.001). No significant association was found for known candidate gene loci on 3q, such as ADIPOQ and IGF2BP2. Using the available samples, we have observed disease associations of SNPs derived from two novel gene loci in ..
  22. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  23. pmc Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians
    Konsta Duesing
    Section of Genomic Medicine, Imperial College London, Hammersmith Campus, London, U K
    Diabetes 57:1992-6. 2008
    We performed a comprehensive genetic association study of common variation spanning the IGF2BP2 locus in order to replicate the association of the "confirmed" type 2 diabetes susceptibility variants rs4402960 and rs1470579 in the French ..
  24. pmc Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies
    Joshua P Lewis
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 57:2220-5. 2008
    ..Our objective was to examine the influence of type 2 diabetes genes identified in whole-genome association studies in a large African American case-control population...
  25. pmc Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
    Maggie C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Diabetes 57:2226-33. 2008
    ..However, the implications of these genes in Asians are unclear...
  26. pmc Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    Hana Lango
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 57:3129-35. 2008
    ..Here, we assess the ability of 18 confirmed type 2 diabetes variants to differentiate between type 2 diabetic case and control subjects...
  27. pmc Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    BMC Med Genet 9:59. 2008
    ..proliferator-activated receptor gamma 2 (PPARG2; rs 1801282); insulin-like growth factor two binding protein 2 (IGF2BP2; rs 4402960); cyclin-dependent kinase 5, a regulatory subunit-associated protein1-like 1 (CDK5; rs7754840); a ..
  28. doi Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps
    M J Groenewoud
    Department of Molecular Cell Biology, Leiden University Medical Center LUMC, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Diabetologia 51:1659-63. 2008
    ..Genome-wide association studies have recently identified novel type 2 diabetes susceptibility gene regions. We assessed the effects of six of these regions on insulin secretion as determined by a hyperglycaemic clamp...
  29. pmc Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population
    Ying Wu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 57:2834-42. 2008
    Genome-wide association studies have identified common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, HHEX/IDE, EXT2, and LOC387761 loci that significantly increase the risk of type 2 diabetes...
  30. pmc Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
    Mandy van Hoek
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes 57:3122-8. 2008
    ..Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 diabetes in the general population is unclear...
  31. doi SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
    Hiroyuki Unoki
    Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Nat Genet 40:1098-102. 2008
    ..5 x 10(-3); OR = 1.14, rs2237897, P = 2.4 x 10(-4); OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 x 10(-11); OR = 1.24, rs2237897, P = 1.2 x 10(-4); OR = 1.36)...
  32. doi Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles
    L Pascoe
    The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Diabetologia 51:1989-92. 2008
    ..The aim of this study was to test the cumulative effects of diabetes-risk alleles on measures of beta cell function in non-diabetic individuals...
  33. doi Common type 2 diabetes risk gene variants associate with gestational diabetes
    Jeannet Lauenborg
    Center for Pregnant Women with Diabetes, Department of Obstetrics, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:145-50. 2009
    ..We aimed to examine the association between gestational diabetes mellitus (GDM) and 11 recently identified type 2 diabetes susceptibility loci...
  34. pmc Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians
    Rong Rong
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 58:478-88. 2009
    In recent genome-wide association studies, variants in CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, CDKN2B, LOC387761, and FTO were associated with risk for type 2 diabetes in Caucasians...
  35. pmc Genotype score in addition to common risk factors for prediction of type 2 diabetes
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 359:2208-19. 2008
    ..We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone...
  36. doi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  37. pmc Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening
    Yasuharu Tabara
    Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Diabetes 58:493-8. 2009
    ..A total of 11 previously reported single-nucleotide polymorphisms (SNPs) from the TCF7L2, CDKAL1, HHEX, IGF2BP2, CDKN2A/B, SLC30A8, and KCNJ11 genes were analyzed.
  38. doi Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies
    Stephanie May Ruchat
    Department of Preventive Medicine, Laval University, Quebec City, QC, Canada
    Acta Diabetol 46:217-26. 2009
    ..We analysed 23 SNPs in 9 T2DM genes (CDKAL1, CDKN2B, HHEX/IDE, IGF2BP2, KCNJ11, SLC30A8, TCF2, TCF7L2 and WFS1) in a maximum of 712 men and women from the Quebec Family Study...
  39. doi Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study
    X Lin
    Discovery Analytics, GlaxoSmithKline, Collegeville, PA, USA
    Diabetologia 52:600-8. 2009
    ....
  40. pmc Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans
    Xia Li
    Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine of USC, Los Angeles, California, USA
    Obesity (Silver Spring) 17:729-36. 2009
    Genome-wide association studies showed variation in insulin-like growth factor-2 binding protein 2 (IGF2BP2) to be associated with type 2 diabetes mellitus (T2DM)...
  41. doi Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes
    N Pulizzi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Diabetologia 52:825-9. 2009
    ..of this study was to investigate whether there is an interaction between birthweight and common variants in the TCF7L2, HHEX, PPARG, KCNJ11, SLC30A8, IGF2BP2, CDKAL1, CDKN2A/2B and JAZF1 genes in the risk of developing type 2 diabetes.
  42. pmc Type 2 diabetes risk alleles are associated with reduced size at birth
    Rachel M Freathy
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 58:1428-33. 2009
    ..We tested whether common genetic variants that predispose to type 2 diabetes also reduce birth weight...
  43. pmc Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism
    Mandy van Hoek
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes 58:1440-4. 2009
    ..We investigated the effects of such well-studied polymorphisms and their interactions with fetal malnutrition on type 2 diabetes risk and related phenotypes in the Dutch Famine Birth Cohort...
  44. pmc Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
    Fumihiko Takeuchi
    Department of Medical Ecology and Informatics, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Diabetes 58:1690-9. 2009
    ..To identify novel type 2 diabetes gene variants and confirm previously identified ones, a three-staged genome-wide association study was performed in the Japanese population...
  45. pmc Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men
    Alena Stancakova
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 58:2129-36. 2009
    ..We investigated the effects of 18 confirmed type 2 diabetes risk single nucleotide polymorphisms (SNPs) on insulin sensitivity, insulin secretion, and conversion of proinsulin to insulin...
  46. pmc Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2414-8. 2009
    ..In order to investigate whether type 2 diabetes risk-conferring alleles associate with low birth weight in our Caucasian childhood cohort, we examined the effects of 20 such loci on this trait...
  47. pmc PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    PLoS ONE 4:e7643. 2009
    ..In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism...
  48. doi Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore
    Jonathan T Tan
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Clin Endocrinol Metab 95:390-7. 2010
    ..However, the association in other East Asian populations is less well characterized...
  49. doi Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypes
    Stephanie May Ruchat
    Department of Preventive Medicine, Laval University, Quebec, Canada
    J Nutrigenet Nutrigenomics 2:225-34. 2009
    ..The objective of this study was to test the hypothesis that the associations between single nucleotide polymorphisms (SNPs) in these genes and adiposity and glucose homeostasis-related phenotypes are influenced by dietary fat intake...
  50. pmc Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians
    Ganesh Chauhan
    Functional Genomics Unit, Institute of Genomics and Integrative Biology CSIR, Delhi, India
    Diabetes 59:2068-74. 2010
    Common variants in PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 genes have been shown to be associated with type 2 diabetes in European populations by genome-wide association studies...
  51. pmc Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population
    Xueyao Han
    Department of Endocrinology and Metabolism, Peking University People s Hospital, Peking University Diabetes Center, no 11, XiZhiMen South Street, Beijing, China
    BMC Med Genet 11:81. 2010
    ..association studies have identified many novel genetic loci for type 2 diabetes (T2D); among these genes, CDKAL1, IGF2BP2, SLC30A8, CDKN2A/B, HHEX, FTO, TCF2, KCNQ1, and WFS1 are the most important...
  52. doi Replication of recently described type 2 diabetes gene variants in a South Indian population
    Manickam Chidambaram
    Department of Molecular Genetics, Madras Diabetes Research Foundation ICMR Advanced Centre for Genomics of Diabetes, Chennai 603103, India
    Metabolism 59:1760-6. 2010
    ..003) of the CDKN2A/B gene, rs7923837 (P = .038) of the HHEX gene, and rs12056034 (P = .033) of the BAZ1B gene were associated with T2D in our population. Large-scale studies are needed in our population to validate our findings...
  53. doi Association between IGF2BP2 rs4402960 polymorphism and risk of type 2 diabetes mellitus: a meta-analysis
    Hongxia Jia
    Department of Endocrinology and Metabolism, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Arch Med Res 42:361-7. 2011
    Genome-wide association studies recently found IGF2BP2 rs4402960 polymorphism associated with enhanced risk of type 2 diabetes mellitus (T2DM). Numerous studies have been published to replicate the association...
  54. doi Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk
    Jie Wu
    Department of Endocrinology, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai 200433, People s Republic of China
    Acta Diabetol 49:S87-97. 2012
    ..This meta-analysis demonstrated that these two common polymorphisms is a risk factor for developing T2D, but these associations vary in different ethnic populations...
  55. pmc Two isoforms of the mRNA binding protein IGF2BP2 are generated by alternative translational initiation
    Hang T T Le
    University of Cambridge Metabolic Research Laboratories and Department of Clinical Biochemistry, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS ONE 7:e33140. 2012
    b>IGF2BP2 is a member of a family of mRNA binding proteins that, collectively, have been shown to bind to several different mRNAs in mammalian cells, including one of the mRNAs encoding insulin-like growth factor-2...
  56. doi IGF2BP2 and IGF2 genetic effects in diabetes and diabetic nephropathy
    Tianwei Gu
    Department of Molecular Medicine and Surgery, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    J Diabetes Complications 26:393-8. 2012
    The IGF2BP2 gene is located on chromosome 3q27.2 within a region linked to type 1 diabetes (T1D), type 2 diabetes (T2D) and diabetic nephropathy (DN). Its protein functionally binds to 5'-UTR of the imprinting IGF2 gene...
  57. pmc The rs11705701 G>A polymorphism of IGF2BP2 is associated with IGF2BP2 mRNA and protein levels in the visceral adipose tissue - a link to type 2 diabetes susceptibility
    Dimitry A Chistiakov
    Pirogov Russian State Medical University, 117997 Moscow, Russia
    Rev Diabet Stud 9:112-22. 2012
    Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) regulates translation of IGF2, a growth factor that plays a key role in controlling fetal growth and organogenesis including adipogenesis and pancreatic development...
  58. ncbi Replication of association study between type 2 diabetes mellitus and IGF2BP2 in Han Chinese population
    Si Min Zhang
    Department of Endocrinology and Metabolism, Peking University People s Hospital, Peking University Diabetes Center, Beijing 100044, China
    Chin Med J (Engl) 126:4013-8. 2013
    The association between IGF2BP2 and type 2 diabetes mellitus (T2DM) has been repeatedly confirmed among different ethnic populations...
  59. pmc A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development
    J Nielsen
    RNA Regulation Centre, Institute of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Mol Cell Biol 19:1262-70. 1999
    ..The results imply that cytoplasmic 5' UTR-binding proteins control IGF-II biosynthesis during late mammalian development...
  60. ncbi Autoantibodies to IGF-II mRNA binding protein p62 and overexpression of p62 in human hepatocellular carcinoma
    Jianying Zhang
    Department of Molecular and Experimental Medicine, W M Keck Autoimmune Disease Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Autoimmun Rev 1:146-53. 2002
    ....
  61. ncbi Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer
    Niels A Hammer
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Reproduction 130:203-12. 2005
    Insulin-like growth factor-II mRNA-binding proteins 1, 2 and 3 (IMP1, IMP2 and IMP3) belong to a family of RNA-binding proteins implicated in mRNA localization, turnover and translational control...
  62. doi Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan
    Yukio Horikawa
    Department of Diabetes and Endocrinology, Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan
    J Clin Endocrinol Metab 93:3136-41. 2008
    ..and populations of European origin, several groups have recently identified novel type 2 diabetes susceptibility genes, including FTO, SLC30A8, HHEX, CDKAL1, CDKN2B, and IGF2BP2, none of which were in the list of functional candidates.
  63. pmc Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  64. doi Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population
    Y M Cho
    Department of Internal Medicine, College of Medicine, Seoul National University, 28 Yongon dong Chongno gu, Seoul 110 744, Korea
    Diabetologia 52:253-61. 2009
    ..The aim of the present study was to examine the association between these diabetogenic variants and gestational diabetes mellitus (GDM)...
  65. pmc Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study
    Philippa J Talmud
    Centre of Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF
    BMJ 340:b4838. 2010
    ....
  66. pmc IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetes
    S Rodriguez
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Growth Horm IGF Res 20:310-8. 2010
    Genetic variation at the insulin-like binding protein 2 (IGF2BP2) gene has been associated with type 2 diabetes (T2D) by genome-wide association studies and by replication analyses...
  67. pmc A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma
    J Y Zhang
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Exp Med 189:1101-10. 1999
    ..However, the possible involvement of p62 autoantigen as a factor in the transformation process remains to be elucidated...
  68. doi Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population
    Yong Ho Lee
    Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon dong Seodaemun gu, Seoul 120 752, South Korea
    J Hum Genet 53:991-8. 2008
    ..aim of the present study was to investigate the association among the polymorphisms of SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1 and KCNQ1 and the risk of T2DM in the Korean population...
  69. doi The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity
    Axel Haupt
    Medical Clinic, Department of Endocrinology, Metabolism, Nephrology and Angiology, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 94:1775-80. 2009
    ..We assessed whether the risk alleles in TCF7L2, CDKAL1, HHEX, SLC30A8, IGF2BP2, CDKN2A/2B, JAZF1, and WFS1 reduce insulin secretion in an additive manner and whether their impact is influenced ..
  70. pmc Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
    S M Ruchat
    Department of Social and Preventive Medicine, PEPS Laval University, 2300 rue de Terrasse, Quebec, QC, Canada G1V 0A6
    Diabetologia 53:679-89. 2010
    ....
  71. doi Type 2 diabetes susceptibility loci in the Ashkenazi Jewish population
    Michal Bronstein
    Department of Genetics, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel
    Hum Genet 124:101-4. 2008
    ..Our study, however, strongly supports the robustness of WGA studies for the identification of genes affecting complex traits in general and T2D in particular...
  72. doi Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies
    C Herder
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Centre at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Horm Metab Res 40:722-6. 2008
    ..30-1.39, p-values 0.0008-0.0004]. In addition, we found evidence for association of SNPs in the genes PPARG, IGF2BP2, HHEX, TCF7L2, and FTO with type 2 diabetes in the same directions as previously described (p<0...
  73. pmc Leptospiral proteins recognized during the humoral immune response to leptospirosis in humans
    H Guerreiro
    , Oswaldo Cruz Foundation, Brazilian Ministry of Health, 40295-001, Brazil
    Infect Immun 69:4958-68. 2001
    ..These findings indicate that leptospiral proteins recognized during natural infection are potentially useful for serodiagnosis and may serve as targets for vaccine design...
  74. doi Long-range atmospheric transport of three toxaphene congeners across Europe. Modeling by chained single-box FATEMOD program
    Jaakko Paasivirta
    Department of Chemistry, University of Jyvaskyla, P O Box 35, 40014, Jyvaskyla, Finland
    Environ Sci Pollut Res Int 16:191-205. 2009
    ..Polychlorobornanes analyzed in biota of the Barents Sea offered one case to study this modeling alternative, while toxaphene has been and partly still is used massively at southern East Europe and around rivers flowing to the Aral Sea...
  75. ncbi Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import
    P Percipalle
    MRC Laboratory of Molecular Biology, Cambridge, England
    J Mol Biol 266:722-32. 1997
    ..Our results are consistent with models for nuclear protein import in which Ran nucleotide exchange modulates the binding of the importin-substrate complexes during translocation through nuclear pore complexes...
  76. pmc Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor
    M Reedijk
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 10:5601-8. 1990
    ..The interaction between the CSF-1 receptor and PI 3'-kinase may contribute to c-fms fibroblast transformation and play a role in CSF-1-stimulated macrophages...
  77. doi Numerous FUS-positive inclusions in an elderly woman with motor neuron disease
    Yukio Fujita
    Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Neuropathology 31:170-6. 2011
    ..Therefore, we consider that the age of onset and clinical features of FUS-related disorders may be variable...
  78. pmc The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src
    K Neet
    Graduate Program in Neurosciences, University of California, San Diego, La Jolla 92093, USA
    Mol Cell Biol 15:4908-20. 1995
    ..Our results suggest that GAP-A.p62 may function as a docking protein and may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation...
  79. ncbi Development of local connections in ferret somatosensory cortex
    S L Juliano
    Department of Anatomy and Cell Biology, USUHS, Bethesda, Maryland 20814, USA
    J Comp Neurol 374:259-77. 1996
    ..This study of the development of the somatosensory cortex confirms the ubiquitous nature of column-like connections throughout the neocortex and provides a novel view of the radial nature of early neocortical maturation...
  80. doi p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis
    Anna Nogalska
    Department of Neurology, USC Neuromuscular Center, Good Samaritan Hospital, University of Southern California Keck School of Medicine, Los Angeles, CA 90017 1912, USA
    Acta Neuropathol 118:407-13. 2009
    ....
  81. ncbi Function and assembly of nuclear pore complex proteins
    K Bodoor
    Department of Cell Biology and Anatomy, University of Calgary, AB, Canada
    Biochem Cell Biol 77:321-9. 1999
    ..These findings support a model in which it is POM121 rather than gp210 that defines initial membrane-associated NPC assembly intermediates and which may therefore represent an essential component of the central framework of the NPC...
  82. pmc PCR typing of genetic determinants for metallo-beta-lactamases and integrases carried by gram-negative bacteria isolated in Japan, with focus on the class 3 integron
    Naohiro Shibata
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan
    J Clin Microbiol 41:5407-13. 2003
    ..In the present study, it was confirmed that strains carrying bla(IMP-1) with a class 1 integron are the most prevalent type in Japan, although several intI3 carriers have also been identified sporadically in this country...
  83. ncbi The CREB-binding protein (CBP) cooperates with the serum response factor for transactivation of the c-fos serum response element
    S Ramirez
    Laboratoire Oncogenese, Differenciation et Transduction du Signal, CNRS UPR 9079, Institut Fédératif sur le Cancer, 7 rue Guy Moquet, 94801 Villejuif, France
    J Biol Chem 272:31016-21. 1997
    ....
  84. pmc Mitosis and inhibition of intracellular transport stimulate palmitoylation of a 62-kD protein
    D I Mundy
    Imperial Cancer Research Fund, London, United Kingdom
    J Cell Biol 116:135-46. 1992
    ..We suggest that the acylation and deacylation of p62 may be important in vesicular transport and that this process may be regulated during mitosis...
  85. ncbi Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor
    J Tang
    The Ben May Institute for Cancer Research and the Department of Pharmacological and Physiological Sciences, The University of Chicago, Illinois 60637, USA
    Oncogene 15:1823-32. 1997
    ..This study suggests that the GAP-associated p62 acts as an SH2 domain docking protein and mediates the interaction between Nck and EGF receptor in response to EGF stimulation...
  86. ncbi Group II intron reverse transcriptase in yeast mitochondria. Stabilization and regulation of reverse transcriptase activity by the intron RNA
    S Zimmerly
    Departments of Molecular Genetics and Biochemistry, The Ohio State University, Columbus, OH, 43210, USA
    J Mol Biol 289:473-90. 1999
    ..Together, our results show that binding to intron-containing RNAs stabilizes and regulates the activity of p62...
  87. pmc Furin processing and proteolytic activation of Semliki Forest virus
    Xinyong Zhang
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Virol 77:2981-9. 2003
    ..However, the in vivo infectivity of mutant L was more strongly inhibited than that of wt/p62, due to additional effects of the mutation on virus-cell binding...
  88. doi Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry
    Maria Pikkarainen
    Department of Clinical Medicine, Unit of Neurology, Section of Neuropathology, Kuopio University Hospital, Kuopio, Finland
    J Neuropathol Exp Neurol 67:280-98. 2008
    ....
  89. pmc Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly
    P Grandi
    Biochemie Zentrum Heidelberg BZH, University of Heidelberg, Germany
    Mol Biol Cell 8:2017-38. 1997
    ....
  90. ncbi Mutations that promote furin-independent growth of Semliki Forest virus affect p62-E1 interactions and membrane fusion
    Xinyong Zhang
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Virology 327:287-96. 2004
    ..Sequence analysis of the pci mutants identified mutations primarily on the E2 protein, and suggested sites important in the interaction of p62 with E1 and the regulation of fusion...
  91. pmc Bergmann glial S100B activates myo-inositol monophosphatase 1 and Co-localizes to purkinje cell vacuoles in SCA1 transgenic mice
    Parminder J S Vig
    Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Cerebellum 8:231-44. 2009
    ..This may cause BG-PC interface to degenerate resulting in vacuolar formation. In sum, these data indicate that vacuoles appearing early in SCA1 PCs could be developing through some unknown autophagic mechanism...
  92. ncbi p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    Serhiy Pankiv
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 282:24131-45. 2007
    ..In fact, p62 bodies and these structures are indistinguishable. Taken together, our results clearly suggest that p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy...
  93. ncbi Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization
    M Carmo-Fonseca
    European Molecular Biology Laboratory, Heidelberg Federal Republic of Germany
    Eur J Cell Biol 55:17-30. 1991
    ....
  94. ncbi Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62
    L E Marengere
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Biol Chem 267:22779-86. 1992
    ..Loss-of-function and gain-of-function mutations in the GAP SH2 domains can therefore be used to identify residues that are critical for receptor and p62 binding...
  95. pmc The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants
    J Y Masson
    Centre hospitalier de l Universite Laval, Health and Environment, Quebec, Canada
    Mol Cell Biol 16:2091-100. 1996
    ..A DNA clone containing the IMP2 gene that complemented the most sensitive bleomycin mutant was identified...
  96. pmc Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins
    T Hu
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biol 134:589-601. 1996
    ..These data support a model in which the p62 complex binds to a multicomponent particle consisting of transport ligand and cytosolic factors to achieve accumulation of ligand near the central gated channel of the nuclear pore complex...
  97. ncbi Expression of ubiquitin-binding protein p62 in ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis with dementia: analysis of five autopsy cases with broad clinicopathological spectrum
    Toshiya Nakano
    Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, 36 1 Nishi cho, 683 8504, Yonago, Japan
    Acta Neuropathol 107:359-64. 2004
    ..Since p62 is believed to have a neuroprotective role, the formation of these inclusions may represent a non-harmful, rather protective effect against the neuronal degeneration in ALSD...
  98. ncbi Sequestosome 1: mutation frequencies, haplotypes, and phenotypes in familial Paget's disease of bone
    Jean Morissette
    Centre de recherche en endocrinologie moléculaire et oncologique, Centre de Recherche du Centre Hospitalier de l Universite Laval, Quebec, Quebec, Canada
    J Bone Miner Res 21:P38-44. 2006
    ..The P392L mutation was the most prevalent, embedded in two different haplotypes, possibly shared by other populations. We also examined the phenotype and penetrance of P392L...
  99. ncbi In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62
    Conny Stumptner
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Hepatology 46:851-60. 2007
    ....
  100. ncbi Interaction of the transcription factor Sp1 with the nuclear pore protein p62 requires the C-terminal domain of p62
    I Han
    Department of Medicine, University of Alabama at Birmingham 35294, USA
    J Cell Biochem 68:50-61. 1998
    ..We propose that this interaction of a nuclear pore protein with Sp1 may reflect the nuclear organization required to bring transcribable DNA in contact with the transcription factors...
  101. ncbi Canine distemper virus induces human osteoclastogenesis through NF-kappaB and sequestosome 1/P62 activation
    Peter L Selby
    Vitamin D Research Group, University School of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, United Kingdom
    J Bone Miner Res 21:1750-6. 2006
    ..We studied the effects of CDV on osteoclastogenesis in vitro and showed that CDV had a dose-dependent effect on osteoclastogenesis, through a possible mechanism involving activation of NF-kappaB and sequestosome 1/p62...

Research Grants81

  1. Mechanisms of Ubiquitin Trafficking in Neurons
    Michael C Wooten; Fiscal Year: 2013
    ....
  2. Arunabh Bhattacharya; Fiscal Year: 2014
    ..abstract_text> ..
  3. Role of p62 in Protein Aggregation and Neurodegeneration in ALS
    Haining Zhu; Fiscal Year: 2009
    ..Purchase of necessary equipment, supplies and reagents for the proposed research will also stimulate the economy as intended by the American Recovery &Reinvestment Act. ..
  4. Wei Xing Zong; Fiscal Year: 2016
    ..At the clinical level, it may establish LC3 or SCCA1 as a molecular signature for suggesting treatment with proteotoxic agents. ..
  5. Junichi Sadoshima; Fiscal Year: 2014
    ..The knowledge obtained from this study may lead to better understanding of the mechanism of myocardial injury and heart failure and the development of novel strategies to treat patients with myocardial infarction and cardiomyopathy. ..
  6. Brendan Cormack; Fiscal Year: 2014
    ..Deletions of the Ssn2/Ssn3/Ssn8/Srb8 module of Mediator results in a 10-fold increase in virulence, and deletion of Imp2', a poorly understood regulator of stress genes in S. cerevisiae, profoundly decreases virulence in C...
  7. Joseph Avruch; Fiscal Year: 2016
    ..Among them is an RNA binding protein IMP2, first discovered by its ability to bind to an IGF2 mRNA expressed primarily in fetal life, whose translation is ..
  8. AIDS Opportunistic Infections: Virulence of C. glabrata
    Brendan Cormack; Fiscal Year: 2009
    ..Deletions of the Ssn2/Ssn3/Ssn8/Srb8 module of Mediator results in an 10x increase in virulence, and deletion of Imp2', a poorly understood regulator of stress genes in S. cerevisiae, profoundly decreases (100x) virulence in C...
  9. REGULATION OF HEPATIC INSULIN EXTRACTION
    Kenneth S Polonsky; Fiscal Year: 2013
    ..We propose to study the T2DM-associated genes KCNJ11, TCF7L2, KCNQ1, CDKAL1, IGF2BP2 and SLC30A8 since it appears that diabetes-associated variants in these genes increase T2DM risk by decreasing ..
  10. Molecular mechanism underlying Frontotemporal Lobar Regeneration
    David Medina; Fiscal Year: 2013
    ..Successful completion of these proposed studies will represent a significant contribution to the field, and the data obtained has the potential to identify novel therapeutic targets in the fight against FTLD and TDP-43 proteinopathies. ..
  11. Autophagy and human islet amyloid polypeptide in animal models of type 2 diabetes
    Jacqueline Rivera; Fiscal Year: 2013
    ....
  12. Stephen B Howell; Fiscal Year: 2014
    ....
  13. Steven M Lipkin; Fiscal Year: 2015
    ..The overall goal of this project is to understand the mechanism of Agr2-/- intestinal epithelia, macrophage and abnormal host microflora interaction to cause multinucleate giant cells, granulomas, ileitis and colitis. ..
  14. Rhea M Sumpter; Fiscal Year: 2014
    ....
  15. A Phase 0 Trial of Hydroxychloroquine in Patients with Stage III and IV Resectabl
    Janice Mehnert; Fiscal Year: 2010
    ..Our hope is that we will be able to use these results to better understand and detect autophagy, making it easier to develop future drugs against this pathway in cancer. ..
  16. Michael Karin; Fiscal Year: 2016
    ..The completion of these studies will result in a much better understanding of the molecular etiology of PanCa and may lead to new strategies for blocking the progression of precursor lesions to invasive PDAC. ..
  17. Autophagy, p62 and the Nrf2 Intersect to Protect Against Tau Toxicity
    Gail V W Johnson; Fiscal Year: 2013
    ..2. That the Nrf2 pathway plays a role in facilitating the degradation of pathological forms of tau. 3. That activation of the Nrf2 or autophagy pathway results in increased survival of cells that express pathological forms of tau. ..
  18. Margaret Kielian; Fiscal Year: 2016
    ..We will define the novel mechanisms that protect the RuV fusion protein from low pH inactivation during virus biogenesis. ..
  19. Function of intramembrane aspartic protease
    Evgeny I Rogaev; Fiscal Year: 2012
    ..We plan to provide evidence for the essential role of this protein in CNS development and signaling in neurulation, which if disrupted, underlies anencephaly, a most common congenital brain defect in humans. ..
  20. The role of phosphorylation of Ulk1 by GSK-3b in myocardial autophagy and aging
    Peiyong Zhai; Fiscal Year: 2013
    ..abstract_text> ..
  21. Loss-of-function mechanisms in Huntington's Disease
    Scott O Zeitlin; Fiscal Year: 2013
    ..We propose experiments that will help us to understand how the mutation affects htt normal function so that we can discover new therapeutic strategies based on restoring htt function in people affected with HD. ..
  22. Joanna C Bakowska; Fiscal Year: 2016
    ....
  23. P62, Protein Aggregation and Fatty Liver Disease
    Martin Obin; Fiscal Year: 2005
    ..Data obtained will be directed to the prevention and treatment of NASH and other age- associated protein aggregation diseases. ..
  24. Obesity-induced inflammation and insulin resistance by the p62/PKCzeta signaling
    Jorge Moscat; Fiscal Year: 2012
    ....
  25. Elizabeth P Henske; Fiscal Year: 2016
    ....
  26. Edward M Campbell; Fiscal Year: 2015
    ..Understanding the mechanisms by which TRIM5alpha mediates its antiviral effects could allow this knowledge to be harnessed in the form of antiviral therapy for people infected with HIV-1 ..
  27. The p62/atypical PKC signaling complex in Th2 differentiation and asthma
    Jorge Moscat; Fiscal Year: 2012
    ....
  28. Role and mechanism of action of p62/Sqstm1 in Ras-induced tumorigenesis in lung
    Jorge Moscat; Fiscal Year: 2013
    ..abstract_text> ..
  29. Sonia Caprio; Fiscal Year: 2014
    ..examine the relationships between a panel of 16 gene variants (TCF7L2, PPARG, FTO, KCNJ11, NOTCH2, WFS1, CDKAL1, IGF2BP2, SLC30A8, JAZF1, HHEX, CDC123/CAMK1D, WFS1, TSPAN8/LGR5, THADA, ADAMTS9) and measures of beta-cell function in ..
  30. Eric H Baehrecke; Fiscal Year: 2015
    ..The importance of Atg6/Beclin1 and the Vps34 regulatory complex in all normal cells and in cancer illustrate the significance of these studies. ..
  31. GTP BINDING PROTEINS AND INSULIN RECEPTOR SINGNALING
    CHIN SUNG; Fiscal Year: 1999
    ..These proposed studies therefore should provide new insights into IR signaling mechanisms in target cells. ..
  32. STRUCTURE/FUNCTION OF THE TRANS GOLGI NETWORK
    Kathryn Howell; Fiscal Year: 2002
    ..Together, the data obtained using diverse approaches will help us reach our ultimate goal of understanding the structure function of the trans-Golgi and the molecular details of the process of secretion. ..
  33. ANTIBODIES AND ANTIGENS IN HEPATOCELLULAR CARCINOMA
    ENG TAN; Fiscal Year: 2005
    ..Other studies are to determine the target genes(s) of SG2NA and potential protein binding partners. Elucidation of the properties and function of these proteins might contribute to understanding co-activating factors in carcinogenesis. ..
  34. MECHANISM & CONTROL OF HUMAN NUCLEOTIDE EXCISION REPAIR
    Zhen Qiang Pan; Fiscal Year: 2001
    ....
  35. Selective Inhibitors of SRC Family Kinases in Neoplasia
    THOMAS SMITHGALL; Fiscal Year: 2002
    ..Combined with the in vitro assays, we hope to identify novel inhibitory activities that target specific Src kinase isoforms and oncogenic signaling pathways. ..
  36. BREAST CANCER GROWTH SUPPRESSOR GENE
    Graham Casey; Fiscal Year: 2001
    ..One of these candidates may be the human homologue of IMP2, a mitochondrial intermembrane signal peptidase believed to be important in the induction of apoptosis...
  37. MUTANT p62 AND THE ROLE OF THE BONE MICROENVIRONMENT IN PAGET'S DISEASE
    JOLENE WINDLE; Fiscal Year: 2009
    ..The proposed studies should lead to a better understanding of PD, and may therefore facilitate the development of improved therapeutic approaches. ..
  38. Mechanism of M. tuberculosis Phagosome Maturation Arrest
    Vojo Deretic; Fiscal Year: 2008
    ..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
  39. Hyperacidification and Pseudomonas infections in CF
    Vojo Deretic; Fiscal Year: 2006
    ..abstract_text> ..
  40. Autophagy in Tuberculosis
    VOJO P DERETIC; Fiscal Year: 2011
    ..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
  41. Pseudomonas in Cystic Fibrosis-Regulation of Mucoidy
    Vojo Deretic; Fiscal Year: 2006
    ..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
  42. PREDOCTORAL FELLOWSHIPS FOR STUDENTS WITH DISABILITIES
    ROBERT RAINEY; Fiscal Year: 2006
    ..I will undertake complementation studies to determine if IMMP2L will function in place of the yeast homolog, IMP2. Results of this project may lead to developing effective treatments to combat neural diseases caused by defects in ..
  43. INHIBITION OF OSTEOCLAST ACTIVITY BY OIP-1/HSCAL
    SAKAMURI REDDY; Fiscal Year: 2008
    ..abstract_text> ..
  44. Promoting Islet Transplantation with Synthetic Scaffolds
    WILLIAM LOWE; Fiscal Year: 2004
    ..abstract_text> ..
  45. Replication of GWAS for Maternal Glycemia, Birthweight and their Interaction
    WILLIAM LOWE; Fiscal Year: 2009
    ....
  46. NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEM
    Kenneth Hensley; Fiscal Year: 2005
    ..abstract_text> ..
  47. HYPERGLYCEMIA AND VASCULAR CELL SIGNALING
    WILLIAM LOWE; Fiscal Year: 2001
    ..Identifying the signaling pathways that mediate the effects of hyperglycemia on vascular cell function is critical to devising means to prevent these changes and their complications, such as atherosclerosis. ..
  48. Diabetes Genes: Maternal Glycemia and Birth Weight
    WILLIAM LOWE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  49. PDX-1 Expression and Embryonic Stem Cells
    WILLIAM LOWE; Fiscal Year: 2004
    ..Thus, the proposed studies will address novel ways of promoting the differentiation of ES cells into islets with the ultimate goal of enhancing islet cell transplantation. ..
  50. The Progesterone Receptor Gene and Ovarian Cancer Risk
    CELESTE PEARCE; Fiscal Year: 2005
    ..We will also test our previous two case-control studies for any additional identified SNPs, including 326 cases and 493 controls (many of the SNPs have already been tested in these populations). ..
  51. Relationship of Apo B and BHMT: Nutrition and Physiology
    Janet Sparks; Fiscal Year: 2004
    ..A potential link of two pathways whose products or intermediates are associated with increased cardiovascular disease risk could be established. ..
  52. Role of EGFR in Viral Infected Lung Epithelial Cells
    Martha M Monick; Fiscal Year: 2010
    ..Completion of these studies will add to our understanding of mechanisms of RSV infection of airway epithelium and the role of targeted signaling pathways in the subsequent inflammation and life span of infected cells. ..
  53. "Nicotine: Potential therapies and possible pitfalls"
    Russell Brown; Fiscal Year: 2004
    ..Additionally, we plan a final roundtable discussion with all speakers to discuss the commonalities of the positive effects, underlying mechanisms, and adverse effects of nicotine as a potential therapy. ..
  54. DEVELOPMENTAL ASPECTS OF OSTEOCLAST FORMATION IN VITRO
    G Roodman; Fiscal Year: 2005
    ....
  55. PATHOBIOLOGY OF THE OSTEOCLAST IN PAGETS DISEASE
    G Roodman; Fiscal Year: 2002
    ..abstract_text> ..
  56. IGF-1, Oxidative Stress and Cardiovascular Aging
    Jun Ren; Fiscal Year: 2002
    ..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
  57. Mechanisms of Ataxin-1 Mediated Purkinje Cell Death
    PARMINDER VIG; Fiscal Year: 2007
    ..Further, changes observed in SCA-1 patients and in transgenic mice will be compared with that in Machado-Joseph disease/SCA-3, other cerebellar ataxias and normal controls. ..
  58. A Pooled Analysis to Identify New Ovarian Cancer Risk Factors
    Celeste Leigh Pearce; Fiscal Year: 2010
    ..Gaining a better understanding of ovarian cancer, which this project will provide, is critical to identifying women at risk and for improving the outcome for women who are diagnosed with this disease. ..
  59. ESTROGEN INDUCED PROGRESSION IN BREAST CANCER
    Robert Clarke; Fiscal Year: 2001
    ....
  60. OSTEOCLASTS FROM TRANSGENIC MICE
    G Roodman; Fiscal Year: 2009
    ..Our long-term goal will be to characterize the role of ADAM8/a9b1 in the bone destruction which accompanies collagen induced arthritis, which will be started in grant year 5. ..
  61. Role of Acetaldehyde in Alcoholic Cardiomyopathy
    Jun Ren; Fiscal Year: 2008
    ..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
  62. Phenotype-Genotype Interactions and Type 2 Diabetes
    James Meigs; Fiscal Year: 2005
    ..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
  63. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore S Lossos; Fiscal Year: 2010
    ..Further, establishment of a paraffin-based RNA prognostic model using the new methodology of RNA extraction could serve as a paradigm for other lymphomas and tumors. ..
  64. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ....
  65. Ovarian Cancer and Gonadotropin Signaling
    CELESTE PEARCE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  66. Paget's Disease of Bone/Dysplasia:Advances/Challenges
    G Roodman; Fiscal Year: 2006
    ..to become aware of the effectiveness of the various drugs that can be used to treat the two disorders; 5.) to understand the role of surgery in managing the two disorders. ..
  67. LRRK2 Proteomics: Kinase/GTPase Hypothesis and Interaction Partners
    Zhenyu Yue; Fiscal Year: 2007
    ..It will also reveal roles of LRRK2 in regulating or interacting with other molecular pathways. This proposal will provide valuable information for PD therapeutic design directed towards enzymatic activity of LRRK2. [unreadable]..
  68. Signals for Commitment to Radiation Induces Apoptosis
    Alexandru Almasan; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  69. Molecular Analysis of Human Breast Cancer
    Robert Clarke; Fiscal Year: 2007
    ..AIM 4: We will use tissue arrays (multiple cores from archival tissues arrayed on glass slides) to validate and optimize the performance of these classifiers in a retrospective prognostic study of human breast tumors. ..
  70. Program Project Grant-Pathobiology of Paget's Disease
    G Roodman; Fiscal Year: 2007
    ..The knowledge gained from this P01 grant will offer important insights for normal bone cell biology especially for understanding the paracrine regulation of osteoblasts by OCLs. ..