KCNB1

Summary

Gene Symbol: KCNB1
Description: potassium voltage-gated channel subfamily B member 1
Alias: DRK1, Kv2.1, potassium voltage-gated channel subfamily B member 1, delayed rectifier potassium channel 1, potassium voltage-gated channel, Shab-related subfamily, member 1, voltage-gated potassium channel subunit Kv2.1
Species: human

Top Publications

  1. ncbi Proteomic analyses of K(v)2.1 channel phosphorylation sites determining cell background specific differences in function
    Kang Sik Park
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    Channels (Austin) 1:59-61. 2007
  2. doi The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function
    X Q Dai
    Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada T6G 2E1
    Diabetologia 55:1709-20. 2012
  3. pmc Single particle image reconstruction of the human recombinant Kv2.1 channel
    Brian Adair
    The Scripps Research Institute, Department of Cell Biology, La Jolla, California 92037, USA
    Biophys J 94:2106-14. 2008
  4. pmc Localization-dependent activity of the Kv2.1 delayed-rectifier K+ channel
    Kristen M S O'Connell
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Proc Natl Acad Sci U S A 107:12351-6. 2010
  5. ncbi Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current
    M A Post
    Rammelkamp Research Center, Case Western Reserve University, Cleveland, OH 44109, USA
    FEBS Lett 399:177-82. 1996
  6. pmc Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes
    A J Patel
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    EMBO J 16:6615-25. 1997
  7. doi Anomalous diffusion of kv2.1 channels observed by single molecule tracking in live cells
    Aubrey V Weigel
    School of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:3005-8. 2010
  8. ncbi Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus
    Patrick E MacDonald
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Mol Endocrinol 16:2452-61. 2002
  9. ncbi Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon
    Zohar Tiran
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 278:17509-14. 2003
  10. doi SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
    Xiao Qing Dai
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2E1 Canada
    J Cell Sci 122:775-9. 2009

Research Grants

  1. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
  2. Christine Beeton; Fiscal Year: 2015
  3. Bert L Semler; Fiscal Year: 2016
  4. KEITH ALAN VOSSEL; Fiscal Year: 2015
  5. The Role of KV1.3 in Effector T cells
    Peter A Calabresi; Fiscal Year: 2012
  6. Towards understanding the role of sumoylation in ion channel regulation
    Sindhu Rajan; Fiscal Year: 2011
  7. BENJAMIN JORGE; Fiscal Year: 2014
  8. Leslie C Griffith; Fiscal Year: 2014
  9. A New Family of Voltage-gated Potassium Channel Regulaory Subunits
    Steve A N Goldstein; Fiscal Year: 2011
  10. Phosphatase Regulation of Olfactory Bulb Mitral Cell Activity
    Melissa Cavallin Johnson; Fiscal Year: 2011

Detail Information

Publications253 found, 100 shown here

  1. ncbi Proteomic analyses of K(v)2.1 channel phosphorylation sites determining cell background specific differences in function
    Kang Sik Park
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    Channels (Austin) 1:59-61. 2007
    ..1 in different cell types under basal conditions, and in the same cell type under basal versus stimulated conditions...
  2. doi The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function
    X Q Dai
    Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada T6G 2E1
    Diabetologia 55:1709-20. 2012
    ..We hypothesised that this interaction mediates insulin secretion independently of Kv2.1 electrical function...
  3. pmc Single particle image reconstruction of the human recombinant Kv2.1 channel
    Brian Adair
    The Scripps Research Institute, Department of Cell Biology, La Jolla, California 92037, USA
    Biophys J 94:2106-14. 2008
    ..1 may also represent a closed conformation. Substantial cytoplasmic density is closely associated with the T1 tetramerization domain and is ascribed to the approximately 184 kDa C-terminal regulatory domains within each tetramer...
  4. pmc Localization-dependent activity of the Kv2.1 delayed-rectifier K+ channel
    Kristen M S O'Connell
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Proc Natl Acad Sci U S A 107:12351-6. 2010
    ..On the basis of these findings, we propose unique roles for the clustered Kv2.1 that are independent of K(+) conductance...
  5. ncbi Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current
    M A Post
    Rammelkamp Research Center, Case Western Reserve University, Cleveland, OH 44109, USA
    FEBS Lett 399:177-82. 1996
    ..1. Our results indicate that Kv channel subfamilies can form heteromultimeric channels and, for the first time, suggest a possible functional role for the Kv6 subfamily...
  6. pmc Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes
    A J Patel
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    EMBO J 16:6615-25. 1997
    ..In conclusion, we propose that metabolic regulation of the Kv2.1/Kv9.3 heteromultimer may play an important role in hypoxic PA vasoconstriction and in the possible development of PA hypertension...
  7. doi Anomalous diffusion of kv2.1 channels observed by single molecule tracking in live cells
    Aubrey V Weigel
    School of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:3005-8. 2010
    ..The effect of actin cytoskeleton on the diffusion properties of the channels is also investigated in the presence of cytochalasin D, a F-actin binding drug that blocks actin polymerization...
  8. ncbi Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus
    Patrick E MacDonald
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Mol Endocrinol 16:2452-61. 2002
    ..1 through an interaction at the channel N terminus and supports the hypothesis that SNARE proteins modulate secretion through their involvement in regulation of membrane ion channels in addition to exocytic membrane fusion...
  9. ncbi Phosphorylation-dependent regulation of Kv2.1 Channel activity at tyrosine 124 by Src and by protein-tyrosine phosphatase epsilon
    Zohar Tiran
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 278:17509-14. 2003
    ..Together, these results indicate that Tyr(124) is a significant site at which the mutually antagonistic activities of Src and cyt-PTPepsilon affect Kv2.1 phosphorylation and activity...
  10. doi SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability
    Xiao Qing Dai
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2E1 Canada
    J Cell Sci 122:775-9. 2009
    ..Thus, protein SUMOylation can exert a strong inhibitory action on the voltage-dependent K(+) channel Kv2.1 and can regulate cellular excitability in native beta-cells...
  11. pmc Influence of permeant ions on voltage sensor function in the Kv2.1 potassium channel
    Joseph F Consiglio
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA
    J Gen Physiol 123:387-400. 2004
    ..These results provide strong evidence for a direct functional interaction, which is modulated by permeant ions acting at the selectivity filter, between the outer vestibule of the Kv2.1 potassium channel and the voltage sensor...
  12. pmc Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers
    C Valenzuela
    Institute of Pharmacology and Toxicology, CSIC, School of Medicine, Universidad Complutense, Madrid, Spain
    Biophys J 69:418-27. 1995
    ....
  13. ncbi Differential expression of Kv3.1b and Kv3.2 potassium channel subunits in interneurons of the basolateral amygdala
    A J McDonald
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garner s Ferry Road, VA Building 1, C 43, Columbia, SC 29208, USA
    Neuroscience 138:537-47. 2006
    ..1b subunit. The significance of Kv3.2 expression in some parvalbumin+ and somatostatin+ interneurons remains to be determined...
  14. pmc Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channels
    M Pusch
    Istituto di Cibernetica e Biofisica, Consiglio Nazionale della Ricerche, Via De Marini 6, I 16149 Genova, Italy
    Biophys J 78:211-26. 2000
    ..The effects of KCNE1 on the conduction properties are consistent with an interaction of KCNE1 in the outer vestibule of the channel...
  15. ncbi [Mechanism of potassium channel in hypoxia-ischemic brain edema: experiment with neonatal rat astrocyte]
    Xue mei Fu
    Department of Pediatrics, Chengdu Materal and Children Health Hospital, Chengdu 610031, China
    Zhonghua Yi Xue Za Zhi 88:2862-6. 2008
    ..To investigate the mechanism of potassium channel in brain edema caused by hypoxia-ischemia (HI)...
  16. ncbi [Ion channels and epilepsy]
    J A Armijo
    Servicio de Farmacologia Clinica, Hospital Universitario Marques de Valdecilla, Universidad de Cantabria, Santander, Espana
    Rev Neurol 30:S25-41. 2000
    ..We review the role of ligand-gated ion channels and voltage-gated ion channels as a substrate for the epileptogenesis and as targets in the development of new antiepileptic drugs...
  17. pmc VKCDB: voltage-gated potassium channel database
    Bin Li
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    BMC Bioinformatics 5:3. 2004
    ..VKCDB (Voltage-gated potassium [K] Channel DataBase) is a database of structural and functional data on these channels. It is designed as a resource for research on the molecular basis of voltage-gated potassium channel function...
  18. doi Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells
    M Braun
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX37 LJ, UK
    Diabetologia 52:1566-78. 2009
    ..The aim of this study was to characterise electrical activity, ion channels, exocytosis and somatostatin release in human delta cells/pancreatic islets...
  19. pmc Specific and rapid effects of acoustic stimulation on the tonotopic distribution of Kv3.1b potassium channels in the adult rat
    J G Strumbos
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuroscience 167:567-72. 2010
    ..1b protein can change on a time scale of minutes in response to stimulus-driven synaptic activity, permitting auditory neurons to actively adapt their complement of ion channels to changes in the acoustic environment...
  20. pmc Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses
    David A Jacobson
    Deparment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232 0615, USA
    J Physiol 588:3525-37. 2010
    ..8-fold with apamin. These results uncover important repolarizing roles for both Kv and K(Ca) channels and identify distinct roles for SK channel activity in regulating calcium- versus sodium-dependent AP firing...
  21. ncbi [Update on anti-NMDA receptor encephalitis]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Brain Nerve 62:331-8. 2010
    ..In a recent case, a microscopic teratoma was detected on autopsy; therefore exploratory laparotomy may be considered in severe refractory cases...
  22. ncbi Immunohistochemical localization of the voltage-gated potassium channel subunit Kv1.4 in the central nervous system of the adult rat
    Rafael Lujan
    Centro Regional de Investigaciones Biomédicas, Facultad de Medicina, Universidad Castilla La Mancha, Campus Biosanitario, Av de Almansa s n, 02006 Albacete, Spain
    J Chem Neuroanat 26:209-24. 2003
    ..The findings indicate that Kv1.4 channels are widely distributed in the rat brain and suggest that activation of this channel would have different modulatory effects on neuronal excitability...
  23. ncbi Expression of voltage-gated K+ channels in human atrium
    Federica Bertaso
    Cell Signalling Group, Department of Renal Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, Bessemer Road, London, SE5 7PJ, United Kingdom
    Basic Res Cardiol 97:424-33. 2002
    ..2 and Kv2.1 is consistent with the major contribution of Kv1.5 to this current. The physiological significance of the expression of KvLQT1 and Kv1.4 mRNA in the human atrium warrants further investigation...
  24. pmc Localization and function of the Kv3.1b subunit in the rat medulla oblongata: focus on the nucleus tractus solitarii
    Mark L Dallas
    School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds LS2 9NQ, UK
    J Physiol 562:655-72. 2005
    ..Synaptic inputs evoked by stimulation of a region lacking Kv3.1b-IR neurones were not affected, correlating the presence of Kv3.1b in the TS with the pharmacological effects...
  25. doi Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus
    T Su
    Institute of Neuroscience and the 2nd Affiliated Hospital, Guangzhou Medical College, Chang gang dong Road 250, Guangzhou, China 510260
    Neuroscience 157:566-76. 2008
    ..The functional relevance of these changes in Ca(2+) homeostasis and Kv4.2 and KChIP1 expression may be associated with intrinsic neuronal excitability regulation and epileptogenesis...
  26. ncbi [Upregulated voltage-gated potassium channel Kv1.3 on the CD4+CD28null T lymphocyte from patients with acute coronary syndrome]
    Shen Huang
    Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Xin Xue Guan Bing Za Zhi 36:602-7. 2008
    ..The purpose of our study is to observe the voltage-gated potassium channel Kv1.3 expression on CD4+CD28null T cells from the peripheral blood of ACS patients by the patch clamp technique...
  27. pmc Computational identification of residues that modulate voltage sensitivity of voltage-gated potassium channels
    Bin Li
    Department of Biological Sciences, University of Alberta, Edmonton, T6G 2E9, Canada
    BMC Struct Biol 5:16. 2005
    ..We have undertaken such an analysis of voltage-gated potassium channels, a transmembrane protein family whose members play indispensable roles in electrically excitable cells...
  28. pmc Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences
    Hong Wang
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    J Comp Neurol 512:384-98. 2009
    ....
  29. doi Identification of a voltage-gated potassium channel in gerbil hippocampal mitochondria
    Piotr Bednarczyk
    Department of Biophysics, Warsaw University of Life Sciences SGGW, 159 Nowoursynowska St, 02 776 Warsaw, Poland
    Biochem Biophys Res Commun 397:614-20. 2010
    ..3 channel...
  30. ncbi Engineering-specific pharmacological binding sites for peptidyl inhibitors of potassium channels into KcsA
    Christian Legros
    Institut für Neurale Signalverarbeitung, ZMNH, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Biochemistry 41:15369-75. 2002
    ..X chimeras containing the subregion I of the corresponding mammalian Kv1.X channels. This innovative approach may facilitate the high-throughput screening of ligand libraries aimed at the discovery of novel potassium channel modulators...
  31. ncbi Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family
    Pavel Strop
    Howard Hughes Medical Institute and Department of Molecular and Cellular Physiology, Stanford Synchrotron Radiation Laboratory, Stanford University, James H Clark Center E300, 318 Campus Drive, Stanford, CA 94305, USA
    J Mol Biol 343:1055-65. 2004
    ..However, the arrangement of residues is inconsistent with that of canonical serine proteases and DPPX is unlikely to function as a protease (dipeptidyl aminopeptidase)...
  32. ncbi A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis
    Su Jin Kim
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 280:28692-700. 2005
    ..These results strongly support an important novel role for GIP in regulating K(V)1.4 cell surface expression and modulation of A-type potassium currents, which is likely to be critically important for its insulinotropic action...
  33. pmc Evolutionary analyses of KCNQ1 and HERG voltage-gated potassium channel sequences reveal location-specific susceptibility and augmented chemical severities of arrhythmogenic mutations
    Heather A Jackson
    Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    BMC Evol Biol 8:188. 2008
    ..Here, we present the first such analysis of arrhythmia-associated mutations (AAMs) in the HERG and KCNQ1 potassium channels...
  34. ncbi Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels
    Evangelos D Michelakis
    Department of Medicine, University of Alberta, Edmonton, Canada
    Circulation 105:244-50. 2002
    ..We hypothesized that dichloroacetate (DCA), a metabolic modulator that can shift redox balance toward an oxidized state and increase Kv current in myocardial cells, would reverse CH-PHT...
  35. ncbi Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome
    Dierk Thomas
    Universitätsklinik Heidelberg, Innere Medizin III, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Cardiovasc Res 67:487-97. 2005
    ..In this study, we investigate and discuss dominant-negative I(Ks) current reduction by a KCNQ1 deletion mutation identified in a RWS family...
  36. ncbi Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2
    Paola Imbrici
    University of Perugia School of Medicine, Department of Internal Medicine, Section of Human Physiology, Via del Giochetto, I 06126 Perugia, Italy
    Eur J Neurosci 24:3073-83. 2006
    ..Furthermore, EA1 mutations alter heteromeric channel availability which probably modifies the integration properties and firing patterns of neurones controlling cognitive processes and body movements...
  37. ncbi Structural determinants of the regulation of the voltage-gated potassium channel Kv2.1 by the modulatory α-subunit Kv9.3
    Daniel Kerschensteiner
    Max Planck Institut fur experimentelle Medizin, Molekulare Biologie Neuronaler Signale, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    J Biol Chem 278:18154-61. 2003
    ..The effect prevailed in heteromeric channels following co-expression of Kv2.1-P410T with Kv2.1. These data suggest that the alteration of the PXP motif is an important determinant of the regulatory function of modulatory alpha-subunits...
  38. ncbi CSF findings in patients with voltage gated potassium channel antibody associated limbic encephalitis
    S Jarius
    Institute of Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, United Kingdom
    J Neurol Sci 268:74-7. 2008
    ..CSF findings were normal in 23%...
  39. pmc Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b
    John G Strumbos
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    J Neurosci 30:10263-71. 2010
    ..1b tonotopicity may be required for accurate encoding of stimulus features such as modulation rate, and that disruption of this gradient, as occurs in Fmr1(-/-) animals, degrades processing of this information...
  40. ncbi Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels
    Ying Duo Gao
    Molecular Systems, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Proteins 52:146-54. 2003
    ..This study also suggests that the extra net negative charge of IbTX is not related to the selectivity of this peptide for the Maxi-K channel...
  41. pmc Voltage-gated potassium channel autoimmunity mimicking creutzfeldt-jakob disease
    Michael D Geschwind
    Neuroimmunology Laboratory, Hilton 3 78F, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 65:1341-6. 2008
    ..Rapidly progressive dementia has a variety of causes, including Creutzfeldt-Jakob disease (CJD) and neuronal voltage-gated potassium channel (VGKC) autoantibody-associated encephalopathy...
  42. pmc 4-Phenoxybutoxy-substituted heterocycles--a structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3
    Silke B Bodendiek
    Department of Pharmacology, University of California, Davis, Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616, USA
    Eur J Med Chem 44:1838-52. 2009
    ..Taken together, our results demonstrate that the psoralen system is a crucial part of the pharmacophore of phenoxyalkoxypsoralen-type Kv1.3 blockers...
  43. doi Substitution of (R,S)-methadone by (R)-methadone: Impact on QTc interval
    Nicolas Ansermot
    Center for Psychiatric Neurosciences, Department of Psychiatry, Hospital of Cery, Prilly Lausanne, Switzerland
    Arch Intern Med 170:529-36. 2010
    ....
  44. ncbi Differential distribution of Shaker-like and Shab-like K+-channel subunits in goldfish retina and retinal bipolar cells
    S Yazulla
    Department of Neurobiology and Behavior, University at Stony Brook, New York 11794 5230, USA
    J Comp Neurol 396:131-40. 1998
    ....
  45. ncbi Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells
    Ivana Fantozzi
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Diego, 9500 Gilman Drive, MC 0725, La Jolla, 92093 0725, USA
    Am J Physiol Lung Cell Mol Physiol 291:L993-1004. 2006
    ..g., kcnb1-2)...
  46. ncbi SNAREing voltage-gated K+ and ATP-sensitive K+ channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins
    Yuk M Leung
    Departmnet of Physiology, China Medical University, Taichung 40402, Taiwan
    Endocr Rev 28:653-63. 2007
    ..This review discusses this interesting aspect that exocytotic proteins not only promote secretion per se, but also fine-tune beta-cell excitability via modulation of ion channel gating...
  47. ncbi 4-Aminopyridine restores impaired hypoxic pulmonary vasoconstriction in endotoxemic mice
    Fabian Spöhr
    Department of Anaesthesiology, Ruprecht Karls University, Heidelberg, Germany
    Anesthesiology 107:597-604. 2007
    ..Voltage-gated potassium channels play a central role in mediating HPV. The aim of this study was to determine whether 4-aminopyridine (4-AP), a known voltage-gated potassium channel inhibitor, may restore HPV in sepsis...
  48. pmc Internalized Kv1.5 traffics via Rab-dependent pathways
    Alireza Dehghani Zadeh
    Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
    J Physiol 586:4793-813. 2008
    ..The Rab GTPases thus constitute dynamic targets by which cells may modulate Kv1.5 functional expression...
  49. ncbi Voltage-gated potassium channel Kv1.3 in rabbit ciliary epithelium regulates the membrane potential via coupling intracellular calcium
    Yan feng Li
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, Guangdong 510060, China
    Chin Med J (Engl) 121:2272-7. 2008
    ..Ion channels play an important role in these processes. The main aim of this study was to determine whether the well-characterized members of the Kv1 family (Kv1.3) contribute to the Kv currents in ciliary epithelium...
  50. doi [Clinical and immunological profile of limbic encephalitis associated with voltage-gated potassium channel antibodies]
    Javier Lopez
    Hospital Clinic e Institut d Investigació Biomèdica August Pi i Sunyer, Universitat de Barcelona, Espana
    Med Clin (Barc) 133:224-8. 2009
    ..In the present study, we report the clinical, radiological and evolution features of LE associated with VGKC-Ab in our area...
  51. doi Mutations in conserved amino acids in the KCNQ1 channel and risk of cardiac events in type-1 long-QT syndrome
    Christian Jons
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 20:859-65. 2009
    ..The purpose of this study was to investigate whether KCNQ1 mutations in highly conserved amino acid residues within the voltage-gated potassium channel family are associated with an increased risk of cardiac events...
  52. ncbi Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunit
    H Xu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Circ Res 85:623-33. 1999
    ..In vivo telemetric recordings also reveal marked QT prolongation, consistent with a defect in ventricular repolarization, in Kv2.1N216FLAG-expressing transgenic mice...
  53. ncbi Molecular mechanism of the sea anemone toxin ShK recognizing the Kv1.3 channel explored by docking and molecular dynamic simulations
    Ling Jin
    Department of Applied Chemistry, School of Natural Science, Wuhan University of Technology, Wuhan, Hubei 430070, PR China
    J Chem Inf Model 47:1967-72. 2007
    ..3 channel is a dynamic process of conformational rearrangement and energy stabilization. All of these can accelerate the development of ShK structure-based immunosuppressants...
  54. ncbi Voltage-gated ion channel Kv4.3 is associated with Rap guanine nucleotide exchange factors and regulates angiotensin receptor type 1 signaling to small G-protein Rap
    Irina A Potapova
    Department of Physiology and Biophysics, Institute of Molecular Cardiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    FEBS J 274:4375-84. 2007
    ..5 min after addition of angiotensin II and then deactivates rapidly, demonstrating a pattern of activation similar to that of Ras. Our findings show that Kv4.3 regulates angiotensin type 1 receptor signaling to the small G-protein Rap-1...
  55. pmc Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc
    Beverly S Colley
    Department of Biological Science, Programs in Neuroscience and Molecular Biophysics, The Florida State University, Tallahassee, Florida, USA
    BMC Neurosci 10:8. 2009
    ..It is not known how adaptor proteins, which lack catalytic activity, but interact with members of the neurotrophic signaling pathway, might scaffold with ion channels or modulate channel activity...
  56. pmc Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failure
    Lie Gao
    Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, Omaha, 68198 5850, USA
    Am J Physiol Heart Circ Physiol 298:H945-55. 2010
    ..3 expression and subsequent decrease in K(+) current, thereby increasing the excitability of neurons in the RVLM. The ANG II-induced inhibition of Kv4.3 mRNA expression was mediated by ANG II-AT(1)R-ROS-p38 MAPK signaling...
  57. doi Precise localization of the voltage-gated potassium channel subunits Kv3.1b and Kv3.3 revealed in the molecular layer of the rat cerebellar cortex by a pre-embedding immunogold method
    Nagore Puente
    Department of Neurosciences, Faculty of Medicine and Dentistry, Basque Country University, 48940 Leioa, Vizcaya, Spain
    Histochem Cell Biol 134:403-9. 2010
    ..1b than for Kv3.3, and that the labeling intensity for each subunit is higher in specific subcompartments analyzed than in others...
  58. ncbi Developmental expression of voltage-gated potassium channel beta subunits
    M Downen
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Brain Res Dev Brain Res 117:71-80. 1999
    ....
  59. ncbi Molecular cloning and functional characterization of a novel delayed rectifier potassium channel from channel catfish (Ictalurus punctatus): expression in taste buds
    J Kang
    Monell Chemical Senses Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurochem 76:1465-74. 2001
    ..1 and Kv2.2...
  60. ncbi The Roles of N- and C-terminal determinants in the activation of the Kv2.1 potassium channel
    Min Ju
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 278:12769-78. 2003
    ....
  61. ncbi Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel
    Mark L Chapman
    Department of Pharmacology, Duke University, Durham, NC, USA
    Pflugers Arch 451:776-92. 2006
    ..Introduction ofa cadmium (Cd2+)-binding site in the external vestibule of Kv2.1 (drk1), allowed us to functionally characterize a binding site for external monovalent cations...
  62. pmc Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter
    Xi Zoë Zhong
    Ion Channels and Cell Signaling Centre, Division of Basic Medical Sciences, St George s University of London, London SW17 0RE, UK
    J Physiol 588:3277-93. 2010
    ....
  63. doi Pathogenic effects of a novel mutation (c.664_681del) in KCNQ4 channels associated with auditory pathology
    Jeong In Baek
    Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, 702 701, South Korea
    Biochim Biophys Acta 1812:536-43. 2011
    ..Our analysis indicates that the intercellular loop is as significant as the pore region as a potential site of pathogenic effects on KCNQ4 channel function...
  64. doi A frontotemporal dementia-like syndrome mimicking postpartum depression detected by 18F fluorodeoxyglucose positron emission tomography
    Vikas Kotagal
    Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA
    Clin Nucl Med 37:e223-4. 2012
    ..Voltage-gated potassium channel antibody-mediated encephalitis is an increasingly described clinical phenomenon whose presentation may mimic primary neurodegenerative diseases...
  65. doi Fluorescent system based on bacterial expression of hybrid KcsA channels designed for Kv1.3 ligand screening and study
    Kseniya S Kudryashova
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho Maklaya 16 10, 117997 Moscow, Russia
    Anal Bioanal Chem 405:2379-89. 2013
    ..3 ligands, tested nine spider venoms for the presence of Kv1.3 ligands, and conducted guided purification of a channel blocker from scorpion venom...
  66. pmc Antibody-guided photoablation of voltage-gated potassium currents
    Jon T Sack
    Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA
    J Gen Physiol 142:315-24. 2013
    ..These findings demonstrate that subtype-specific mAbs that in themselves do not modulate ion channel function are capable of delivering functional payloads to specific ion channel targets. ..
  67. pmc Amigo adhesion protein regulates development of neural circuits in zebrafish brain
    Xiang Zhao
    From the Neuroscience Center
    J Biol Chem 289:19958-75. 2014
    ..1 potassium channel to form functional neural circuitry that controls locomotion. ..
  68. pmc Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening
    Nicholas E Calcaterra
    Departments of Pharmacology and Molecular Sciences, Baltimore, MD 21205
    Sci Rep 6:19976. 2016
    ..Utilizing this identified phenomenon, an electrophysiological and high throughput in-vitro fluorescent assay platform has been developed for drug discovery in order to explore a potentially new class of cognitive therapeutics...
  69. ncbi Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel
    E Y Isacoff
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Nature 353:86-90. 1991
    ..the inactivated state of ShB as well as the inactivated state induced in the delayed-rectifier type K+ channel drk1 by the cytoplasmic application of the ShB N-terminal peptide...
  70. ncbi Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
    Q Wang
    Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA
    Nat Genet 12:17-23. 1996
    ..These data define KVLQT1 as a novel cardiac potassium channel gene and show that mutations in this gene cause susceptibility to ventricular tachyarrhythmias and sudden death...
  71. ncbi Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development
    C Burger
    Program in Neuroscience, University of Colorado Health Sciences Center, Denver 80262, USA
    J Neurosci 16:1412-21. 1996
    ..1 transcripts are found in dorsal spinal neurons. Thus, spinal neuron subtypes express distinct potassium channel genes, yet they temporally coordinate functional expression of delayed rectifier potassium currents...
  72. ncbi Mutations in the KCNQ4 K+ channel gene, responsible for autosomal dominant hearing loss, cluster in the channel pore region
    P Van Hauwe
    Department of Medical Genetics, University of Antwerp, Belgium
    Am J Med Genet 93:184-7. 2000
    ..The clustering of mutations in this domain confirms its importance...
  73. ncbi The role of Zn2+ in Shal voltage-gated potassium channel formation
    Candace Strang
    Neuroscience Division, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:31361-71. 2003
    ..Therefore, zinc-mediated tetramerization also is a physiologically important event for full-length functional channel formation...
  74. ncbi Ionworks HT: a new high-throughput electrophysiology measurement platform
    Kirk Schroeder
    Essen Instruments, Ann Arbor, MI 48108, USA
    J Biomol Screen 8:50-64. 2003
    ..5) exogenously expressed in CHO cells are presented. The IonWorks HT device can be used in biophysical and pharmacological profiling of ion channels in an environment compatible with high-capacity screening...
  75. pmc The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity
    Jianchao Xu
    Department of Medicine, Yale University School of Medicine, and Veterans Affairs Medical Center, New Haven, CT, USA
    Proc Natl Acad Sci U S A 101:3112-7. 2004
    ..These results pinpoint a pathway through which K channels regulate peripheral glucose homeostasis, and identify Kv1.3 as a pharmacologic target for the treatment of diabetes...
  76. ncbi Inhibition of voltage-gated potassium currents by gambierol in mouse taste cells
    Valeria Ghiaroni
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, 41100 Modena, Italy
    Toxicol Sci 85:657-65. 2005
    ..Thus, gambierol may alter action potential discharge in taste cells and this could be associated with the taste alterations reported in the clinical literature...
  77. ncbi Effects of hyperthyroidism on delayed rectifier K+ currents in left and right murine atria
    Ying Hu
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0618, USA
    Am J Physiol Heart Circ Physiol 289:H1448-55. 2005
    ..the left atrium, which can contribute to the propensity for atrial arrhythmia in hyperthyroid heart...
  78. ncbi Neonatal seizures with tonic clonic sequences and poor developmental outcome
    Bernhard Schmitt
    University Children s Hospital, Steinwiesstrasse 75, CH 8032 Zurich, Switzerland
    Epilepsy Res 65:161-8. 2005
    ....
  79. ncbi Expression of delayed rectifier potassium channels and their possible roles in proliferation of human gastric cancer cells
    Mei Lan
    State Key Laboratory of Cancer Biology and Institute of Digestive Disease, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Cancer Biol Ther 4:1342-7. 2005
    ..Kv1.5 may be involved in tumor cells proliferation by controlling Ca(2+) entry, and the interference of K(D) channels expression and/or activity could provide a novel strategy to reverse the malignant phenotype of gastric cancer cells...
  80. ncbi The Kv2.1 C terminus can autonomously transfer Kv2.1-like phosphorylation-dependent localization, voltage-dependent gating, and muscarinic modulation to diverse Kv channels
    Durga P Mohapatra
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    J Neurosci 26:685-95. 2006
    ..1 channel by cholinergic and other neuromodulatory stimuli...
  81. ncbi Role of protein kinase Czeta and its adaptor protein p62 in voltage-gated potassium channel modulation in pulmonary arteries
    Laura Moreno
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Mol Pharmacol 72:1301-9. 2007
    ..These observations identify PKCzeta and/or p62 as potential therapeutic targets for the treatment of pulmonary hypertension...
  82. pmc Microglia induce neurotoxicity via intraneuronal Zn(2+) release and a K(+) current surge
    Megan E Knoch
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Glia 56:89-96. 2008
    ..These results establish a direct link between microglial-generated oxygen and nitrogen reactive products and neuronal cell death mediated by intracellular Zn(2+) release and a surge in K(+) currents...
  83. doi An overview of trafficking and assembly of neurotransmitter receptors and ion channels (Review)
    Blanche Schwappach
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Mol Membr Biol 25:270-8. 2008
    ..Future progress depends on the improvement of tools, in particular the antibodies used by the field, and the continued exploitation of genetically tractable model organisms in screens and physiological experiments...
  84. ncbi Structural model of the Ca V 1.2 pore
    Anna Stary
    Institute for Theoretical Chemistry, University of Vienna, Vienna, Austria
    Channels (Austin) 2:210-5. 2008
    ..In the accompanying paper these models were used to study structural effects of a channelopathy mutation...
  85. doi Course and outcome of a voltage-gated potassium channel antibody negative Morvan's syndrome
    Carlo Rinaldi
    Department of Neurological Sciences, Federico II University, Via Pansini, 5, 80131, Naples, Italy
    Neurol Sci 30:237-9. 2009
    ..Nevertheless, the good response to corticosteroids therapy and the association with myasthenia confirm an autoimmune origin of the disease...
  86. ncbi Thalamic microinfusion of antibody to a voltage-gated potassium channel restores consciousness during anesthesia
    Michael T Alkire
    Department of Anesthesiology and Perioperative Care, Center for Neurobiology of Learning and Memory, University of California Irvine, Irvine, California, USA
    Anesthesiology 110:766-73. 2009
    ..2 channel might awaken anesthetized rats...
  87. doi Multifocal paraneoplastic cortical encephalitis associated with myasthenia gravis and thymoma
    Khaled Hammoud
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9036, USA
    Arch Neurol 66:1407-9. 2009
    ..To report a case of multifocal cortical encephalitis associated with thymoma and to establish an association of this thymoma-related paraneoplastic syndrome with voltage-gated potassium channel antibodies...
  88. pmc Acquired neuromyotonia following upper respiratory tract infection: a case report
    Ibrahim Imam
    Neurology Department, Torbay Hospital, Torquay TQ2 7AA, UK
    Cases J 2:7952. 2009
    ..His symptoms improved slightly on lamotrigine and amitriptyline...
  89. pmc The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study
    T A Mavlyutov
    Department of Pharmacology, University of Wisconsin, School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA
    Neuroscience 167:247-55. 2010
    ..Together these data indicate that the sigma-1 receptor may play a role in the regulation of motor behavior...
  90. doi Non-conducting function of the Kv2.1 channel enables it to recruit vesicles for release in neuroendocrine and nerve cells
    Lori Feinshreiber
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel
    J Cell Sci 123:1940-7. 2010
    ..These findings place a voltage-gated K(+) channel among the syntaxin-binding proteins that directly regulate pre-fusion steps in exocytosis...
  91. pmc Kv1.3: a potential pharmacological target for diabetes
    Bok Hee Choi
    Department of Pharmacology, Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Jeonbuk, Korea
    Acta Pharmacol Sin 31:1031-5. 2010
    ..Pharmacological strategies for targeting Kv1.3 are then discussed with a focus on a rationale for the potential therapeutic use of Kv1.3 blocker in diabetic treatment...
  92. pmc Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel
    Wade D Van Horn
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 8725, USA
    Curr Opin Struct Biol 21:283-91. 2011
    ..We present a critical review of these structural models, illustrating the strengths and challenges of the integrative approach...
  93. doi VGKC antibodies in pediatric encephalitis presenting with status epilepticus
    J Suleiman
    Children s Hospital at Westmead, Sydney 2145, Australia
    Neurology 76:1252-5. 2011
    ..Voltage-gated potassium channel antibodies (VGKC Ab) are associated with limbic encephalitis and neuromyotonia in adults. There have been no systematic investigations in children to date...
  94. pmc Functional reconstitution of a voltage-gated potassium channel in giant unilamellar vesicles
    Sophie Aimon
    Unité Mixte de Recherche 168, Physico Chimie Curie, Centre National de la Recherche Scientifique, Institut Curie, Centre de Recherche, Universite Pierre et Marie Curie, Paris, France
    PLoS ONE 6:e25529. 2011
    ....
  95. pmc Extending the dynamic range of label-free mass spectrometric quantification of affinity purifications
    Wolfgang Bildl
    Institute of Physiology, University of Freiburg, 79104 Freiburg, Germany
    Mol Cell Proteomics 11:M111.007955. 2012
    ..The enhanced dynamic range of the developed quantification procedure appears well suited for sensitive identification of specific protein-protein interactions, detection of antibody-related artifacts, and optimization of AP conditions...
  96. doi How does KCNE1 regulate the Kv7.1 potassium channel? Model-structure, mutations, and dynamics of the Kv7.1-KCNE1 complex
    Yana Gofman
    Department of Biochemistry and Molecular Biology, Tel Aviv University, 69978 Tel Aviv, Israel
    Structure 20:1343-52. 2012
    ....
  97. doi Limbic encephalitis associated with elevated antithyroid antibodies
    Yael Hacohen
    Children s Neurosciences Center, Evelina Children s Hospital at Guy s and St Thomas NHS Foundation Trust, King s Health Partners Academic Health Sciences Centre, London, UK Nuffield Department of Clinical Neurosciences, West Wing, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Child Neurol 29:769-73. 2014
    ....
  98. pmc Dynamics of internal pore opening in K(V) channels probed by a fluorescent unnatural amino acid
    Tanja Kalstrup
    Groupe d étude des protéines membranaires GÉPROM and Department of Physics, Universite de Montreal, Montreal, QC, Canada H3C 3J7
    Proc Natl Acad Sci U S A 110:8272-7. 2013
    ..Thus, we defined which parts act independently and which parts act cooperatively and found pore opening to occur in two sequential transitions...
  99. pmc Kv2 channels regulate firing rate in pyramidal neurons from rat sensorimotor cortex
    Dongxu Guan
    R C Foehring Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    J Physiol 591:4807-25. 2013
    ..Depolarization and the number of inactivated Na(+) channels would build with successive spikes, resulting in slower firing and enhanced spike frequency adaptation in the Kv2.1 DN cells...
  100. doi Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state
    Yang Yang
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, and Arizona Research Laboratories Division of Biotechnology, University of Arizona, Tucson, Arizona 85721
    J Neurosci 33:16586-93. 2013
    ..2 channel mutation associated with neurological disease. ..
  101. pmc Kv2.2: a novel molecular target to study the role of basal forebrain GABAergic neurons in the sleep-wake cycle
    Tracey O Hermanstyne
    Department of Neural and Pain Sciences Program in Neurosciences Department of Developmental Biology, Washington University, St Louis, MO
    Sleep 36:1839-48. 2013
    ..In this study, we sought to determine the functional roles of the Kv2.2-expressing neurons in the regulation of the sleep-wake cycle...

Research Grants69

  1. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..3+ lymphocytes pre and post treatment in the transplanted skin. The overall goal of this proposal is to determine whether Kv1.3 blockade constitutes a potential new therapeutic approach to the treatment of psoriasis. ..
  2. Christine Beeton; Fiscal Year: 2015
    ..This project will generate novel peptide blockers of Kv1.3, which we believe will be valuable leads in the development of new treatments for MS and other chronic inflammatory diseases. ..
  3. Bert L Semler; Fiscal Year: 2016
    ..abstract_text> ..
  4. KEITH ALAN VOSSEL; Fiscal Year: 2015
    ..The mentoring and research experience described in this proposal will facilitate the candidate's goal of developing a strong independent research career. ..
  5. The Role of KV1.3 in Effector T cells
    Peter A Calabresi; Fiscal Year: 2012
    ..Further, understanding basic mechanisms of T cell function will enhance our knowledge of how the immune system causes disease and allow us to develop novel strategies for correcting abnormal immune responses in diseases like MS. ..
  6. Towards understanding the role of sumoylation in ion channel regulation
    Sindhu Rajan; Fiscal Year: 2011
    ..The Departments of Pediatrics, Neurobiology, Pharmacology and Physiology at the University of Chicago include an internationally recognized cadre of ion channel researchers. ..
  7. BENJAMIN JORGE; Fiscal Year: 2014
    ....
  8. Leslie C Griffith; Fiscal Year: 2014
    ..Understanding how the context of a protein's location can affect or regulate activity is critical to rational drug design and may even provide new drug targets. ..
  9. A New Family of Voltage-gated Potassium Channel Regulaory Subunits
    Steve A N Goldstein; Fiscal Year: 2011
    ..This revised application seeks to address concerns raised in the first review cycle. ..
  10. Phosphatase Regulation of Olfactory Bulb Mitral Cell Activity
    Melissa Cavallin Johnson; Fiscal Year: 2011
    ..The link between these two proteins in the olfactory system has implications not only for sensory function but also for energy homeostasis. ..
  11. CHERYL LYNN VAN BUSKIRK; Fiscal Year: 2015
    ..We will identify this signal through RNAi-based functional genomics, and characterize its function using molecular-genetic approaches. ..
  12. miRNA Regulation of Gene Expression in Alcohol Tolerance and Withdrawal
    Steven N Treistman; Fiscal Year: 2013
    ..In this project we will explore a novel mechanism, acting on gene products, which will provide important insights in our quest for this understanding. ..
  13. ROBERT C FOEHRING; Fiscal Year: 2016
    ..Time coding is important for generation of rhythmic cortical activity such as observed during attention and sensory processing. ..
  14. Identification of the gene causing spinocerebellar ataxia in a Filipino family
    MICHAEL FARRIS WATERS; Fiscal Year: 2012
    ..abstract_text> ..
  15. Glucose Sensitivity of Mitral Cell Neurons of the Olfactory Bulb
    KRISTAL RAYLONE TUCKER; Fiscal Year: 2009
    ..With the ever increasing obese population in the United States, it will be important to understand how the chemistry of the obese state affects brain function. ..
  16. Behavioral Measures of Temporal Resolution in Mice With or Without Kv1.1 Subunits
    Micheal L Dent; Fiscal Year: 2010
    ..It is unknown, however, how this affects the 'real world'listening situation of these animals, so this will be determined here. ..
  17. Neuropathogenesis of Immune Reconstitution Syndrome with HIV Infection
    Avindra Nath; Fiscal Year: 2010
    ..Specific aim 2: To determine the mechanism of GB mediated neurotoxicity Specific aim 3: To determine the mechanism of neuroprotection with Kv1.3 blockers ..
  18. Carlos G Vanoye; Fiscal Year: 2014
    ..Aim 5. Determine the structure of KCNE4 in bilayers and formulate a working model for how KCNE4 inhibits KCNQ1 channel function. ..
  19. The Microglial Kv1.3 Channel in Alzheimer's Disease
    Heike Wulff; Fiscal Year: 2012
    ..3 is important in microglia-caused damage. We will further test whether an inhibitor for Kv1.3 reduces microglia activity in an animal model of Alzheimer's disease. ..
  20. Stephen L Archer; Fiscal Year: 2015
    ..Since HOSK may have arisen independent of the canonical K+ channel family, exploring its structure-function relationship will extend our fundamental knowledge K+ channels. ..
  21. Targeting of Voltage-gated K+ Channels to Lipid Rafts
    Michael Tamkun; Fiscal Year: 2004
    ..1-containing lipid rafts from brain. This proposed research examines a new area in Kv channel research that will have important implications in multiple tissue systems. ..
  22. Kv2.1 membrane corrals:Regulators of K+ channel function and trafficking
    Michael M Tamkun; Fiscal Year: 2012
    ..Mice lacking the Kv2.1 channel are epileptic and hyper-excitable. Understanding the molecular mechanisms underlying Kv2.1 localization will enhance the treatment of stroke and epilepsy. ..
  23. A Mouse Model of Mammalian Shaker Channel RNA Editing
    Tarun Bhalla; Fiscal Year: 2006
    ..The studies outlined below aim to understand the functional consequences of RNA editing of Kv1.1 in the mammalian nervous system. ..
  24. Function of the Sigma-1 Receptor in Motoneurons
    ARNOLD EINO RUOHO; Fiscal Year: 2013
    ..Targeting S1R can potentially establish a new therapeutic treatment for ALS. ..
  25. REGULATORY MECHANISMS OF CARDIAC REPOLARIZATION
    Michael Tamkun; Fiscal Year: 2005
    ..Given the role that both Kv channels and connexins play in cardiac and vascular smooth muscle, the proposed research will significantly advance our understanding of electrical excitability in the cardiovascular system. ..
  26. CaMKII Regulation of Kv4.2 in the Hippocampus
    ANDREW VARGA; Fiscal Year: 2003
    ..2 phosphorylation that occur when hippocampal slices undergo long-term potentiation. Taken together, these data may provide a novel mechanism by which CaMKII affects memo formation. ..
  27. Role of KVS and MPS Subunits in Basic Neuronal Function
    Federico Sesti; Fiscal Year: 2007
    ..3 Aim: To characterize chemosensory neuron physiology in culture and in vivo and to define how KVS and MPS-1 proteins influence amphid neuron basic function. 4 Aim: To establish the superfamily of C. elegans MiRPs. ..
  28. Bacterial Cell Surfaces Gordon Conference
    Barry Rosen; Fiscal Year: 2004
    ..abstract_text> ..
  29. Macromolecular Organization of the Kv2.1 Channel Complex
    Jean Ju Chung; Fiscal Year: 2005
    ..Completion of the proposed research will identify Kv2.1-associated proteins, which provides insights into the mechanism of current diversity and the regulation of neuronal delayed rectifier potassium currents. ..
  30. Chemical Basis for Potassium Channel Modulation
    PAMELA ENGLAND; Fiscal Year: 2006
    ..To determine the site(s) in HERG that interact with other proteins, photoreactive amino acids capable of forming protein cross-links will be site-specifically incorporated into the HERG. ..
  31. Insulin as a Neuromodulator in the Olfactory Bulb
    David Marks; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  32. James S Trimmer; Fiscal Year: 2014
    ....
  33. Steven O Marx; Fiscal Year: 2014
    ..Thus, the proposed research is relevant to public health and to the NIH mission to discover basic mechanisms underlying human disease. ..
  34. Structure and function of potassium channels using yeast
    Steve Goldstein; Fiscal Year: 2004
    ..coli. ..
  35. Robert W Nickells; Fiscal Year: 2016
    ..Since we postulate that reversal of gene silencing is a critical component to reactivate ganglion cells, a complete understanding of the types of epigenetic changes associate with this phenomenon is essential. ..
  36. Targeting SUMO proteases for type II diabetes
    Benjamin Nicholson; Fiscal Year: 2010
    ..In Phase II, the best compounds will be put into preclinical development with the ultimate goal of introducing a new and highly effective drug into the market for T2D. ..
  37. A novel neuroprotective strategy
    Elias Aizenman; Fiscal Year: 2013
    ..abstract_text> ..
  38. Elias Aizenman; Fiscal Year: 2016
    ..abstract_text> ..
  39. Regulation of Kv Channels by Anorexigens
    Bruce Pitt; Fiscal Year: 2007
    ..1 proteins, inhibition of Kv1.5 gene transcription and blockade of Kv currents at plasma membrane. ..
  40. MODULATION OF K+ CHANNEL FUNCTION BY PERMEANTIONS
    Stephen Korn; Fiscal Year: 2004
    ..Furthermore, these experiments will lead to a better understanding of how intracellular channel blockers interact with external pH and K+ to produce physiological and pathological consequences in both brain and heart. ..
  41. Circadian control of behavior in Drosophila
    Steve Kay; Fiscal Year: 2004
    ..abstract_text> ..
  42. MinK-related peptides(MiRPs): structure and function
    Steve Goldstein; Fiscal Year: 2004
    ..Second, they have potential to reveal mechanisms of ion channel function from a unique vantage point: a peptide intimate with (but not of) the pore-forming subunit. ..
  43. Ion channels of neurons
    Stephen Jones; Fiscal Year: 2007
    ..abstract_text> ..
  44. Selective modulation of basal ganglia circuits
    Scott Sherman; Fiscal Year: 2003
    ..Successful completion of this proposal would allow further the development of a gene therapy for the symptomatic treatment of PD. ..
  45. Kv2.1 Channel Modulation of Ethanol Withdrawal
    Patrick Mulholland; Fiscal Year: 2007
    ..Findings from these studies may implicate a novel therapeutic target for possible drug design to treat the severity of alcohol withdrawal and, potentially, relapse. [unreadable] [unreadable] [unreadable]..
  46. Towards the Discovery of HERG PAS Domain Ligands
    James Chambers; Fiscal Year: 2005
    ....
  47. HYPERTENSION: CONTRIBUTION OF ARTERIAL WALL CHANGES
    Robert Cox; Fiscal Year: 2007
    ..These studies will define a novel therapeutic target for antihypertensive drug development based upon the mechanism(s) of Ca2+-Kv channel modulation. ..
  48. SK Channel Openers as Therapeutics for Cerebellar Ataxia
    Heike Wulff; Fiscal Year: 2007
    ..Taken together these important proof-of-concept studies will help to determine whether SK channel openers constitute a new therapeutic approach to improve motor performance in dominant cerebellar ataxias. ..
  49. Small Molecule Kv1.3 Blockers as New Therapeutics for Multiple Sclerosis
    Heike Wulff; Fiscal Year: 2007
    ..Lay: In multiple sclerosis the immune system attacks proteins in the brain of afflicted patients. The aim of this study is to identify and test new drugs that can suppress the white blood cells that are invading the brain. ..
  50. Molecular Basis of Automaticity in the Myometrium
    Glenna Bett; Fiscal Year: 2008
    ..Identification of an ion channel which is the uterine pacemaker offers the opportunity for designing interventions to prevent and delay preterm labor. [unreadable] [unreadable] [unreadable] [unreadable]..
  51. Regulation of Glucose Homeostasis by the Kv1.3 Channel
    Gary Desir; Fiscal Year: 2008
    ..In the context of our preliminary work, we propose to test if Kv1.3 modulate glucose uptake via an insulin-dependent pathway, and to examine the cellular mechanisms that mediate the action of Kv1.3 on glucose metabolism. ..
  52. Regulation of Kv2.1 Trafficking
    KRISTEN O CONNELL; Fiscal Year: 2005
    ..Therefore understanding of this process will contribute to our knowledge of how membrane excitability is regulated. ..
  53. Experimental Dysautonomia: Pathogenesis and Treatment
    Steven Vernino; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  54. Molecular Physiology of Voltage gated Ion Channels
    Richard Horn; Fiscal Year: 2005
    ..The goals are to determine orientations of voltage sensors and gates with respect to surrounding regions of the channel and to see how these orientations change in response to changes of membrane potential. ..
  55. Molecular Dissection of Neuronal K+ Channel Function
    JEANNE NERBONNE; Fiscal Year: 2005
    ..Importantly, it seems likely that the multifaceted experimental approach developed here can also be applied to determine the molecular compositions and functional roles of voltage-gated (and other) K+ channels in other cells. ..
  56. Role of Molecular Chaperones in hERG Processing
    Eckhard Ficker; Fiscal Year: 2008
    ..abstract_text> ..
  57. Molecular Physiology of Voltage-gated Ion Channels
    Richard Horn; Fiscal Year: 2009
    ..The proposed studies should help in the design of therapeutic drugs to treat a variety of malfunctions in excitability. ..
  58. Sequenom MassARRAY High Throughput System
    Mark Leppert; Fiscal Year: 2002
    ..Many of these projects will need to test 50 to 100 candidate genes in up to 5,000 human DNA samples. A significant reduction in cost will lead to faster gene discoveries important for medical science. ..
  59. The World Congress on Chromosome Abnormalities
    Jannine Cody; Fiscal Year: 2004
    ..This application seeks funding for the Scientific Sessions of the World Congress on Chromosome Abnormalities, to be held in June of 2004 in San Antonio, Texas. ..
  60. NMDA RECEPTOR--AGONIST AFFINITY, EFFICACY/TRANSDUCTION
    Antonius VanDongen; Fiscal Year: 2004
    ..These studies will result in a detailed molecular picture of the dynamic change in structure that accompany activation of the NMDA receptor. ..
  61. Structure, Function and Regulation of Renal K Channels
    Gary Desir; Fiscal Year: 2005
    ..These studies should provide important information regarding the molecular structure of KCNA10 and its role in renal solute homeostasis. ..
  62. The Physiological Roles of K Channels in Fluid Secretion
    TED B BEGENISICH; Fiscal Year: 2010
    ..The physiological roles of the two channels will be probed with various physiological measurements of mice deficient in the expression of the two K channelgenes. ..
  63. ION CHANNELS IN THE FUNCTIONING OF CORTICAL NEURONS
    JEANNE NERBONNE; Fiscal Year: 2005
    ..abstract_text> ..
  64. The Role of the Amygdala in Anesthetic-Induced Amnesia
    MICHAEL ALKIRE; Fiscal Year: 2006
    ..abstract_text> ..
  65. Surface Plasmon-coupled Fluorescence Microscope to Study Ion Channel Dynamics
    Francisco Bezanilla; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  66. REPOLARIZATION AND REMODELING IN THE MAMMALIAN HEART
    JEANNE NERBONNE; Fiscal Year: 2008
    ..In the long term, these insights should translate into more effective treatment strategies to reduce the risk of sudden death and the mortality and morbidity associated with myocardial hypertrophy and failure. ..
  67. ELECTROPHYSIOLOGICAL STUDIES OF VOLTAGE GATED CHANNELS
    Francisco Bezanilla; Fiscal Year: 2008
    ..abstract_text> ..
  68. High Throughput Screening for Potassium Channel Modulators
    ELENA MAKHINA; Fiscal Year: 2008
    ..Identified compounds will serve both for basic study of K+ channel physiology and as a basis for development of clinical K+ channel drugs. [unreadable] [unreadable] [unreadable]..
  69. SYNAPTIC ORGANIZATION OF THE BASOLATERAL AMYGDALA
    ALEXANDER MCDONALD; Fiscal Year: 2008
    ..abstract_text> ..