KCNJ2

Summary

Gene Symbol: KCNJ2
Description: potassium voltage-gated channel subfamily J member 2
Alias: ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3, inward rectifier potassium channel 2, IRK-1, cardiac inward rectifier potassium channel, hIRK1, inward rectifier K+ channel KIR2.1, potassium channel, inwardly rectifying subfamily J, member 2, potassium inwardly-rectifying channel, subfamily J, member 2
Species: human

Top Publications

  1. ncbi Primary structure and functional expression of a mouse inward rectifier potassium channel
    Y Kubo
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Nature 362:127-33. 1993
  2. ncbi Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome
    N M Plaster
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Cell 105:511-9. 2001
  3. pmc Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome
    Regina Preisig-Müller
    Institute of Physiology, Marburg University, Deutschhausstrasse 2, 35037 Marburg, Germany
    Proc Natl Acad Sci U S A 99:7774-9. 2002
  4. pmc KCNJ2 mutation results in Andersen syndrome with sex-specific cardiac and skeletal muscle phenotypes
    Gregor Andelfinger
    Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, 45229, USA
    Am J Hum Genet 71:663-8. 2002
  5. ncbi A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene
    Silvia G Priori
    Molecular Cardiology, IRCCS Fondazione Maugeri, Pavia, Italy
    Circ Res 96:800-7. 2005
  6. pmc Mechanism of the voltage sensitivity of IRK1 inward-rectifier K+ channel block by the polyamine spermine
    Hyeon Gyu Shin
    Department of Physiology, University of Pennsylvania, Philadelphia 19104, USA
    J Gen Physiol 125:413-26. 2005
  7. ncbi A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation
    Min Xia
    Institute of Medical Genetics, Tongji University, Shanghai, China
    Biochem Biophys Res Commun 332:1012-9. 2005
  8. pmc Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels
    Brian K Panama
    University of Michigan, Department of Molecular and Integrative Physiology, Ann Arbor, MI 48109 0622, USA
    J Physiol 571:287-302. 2006
  9. ncbi Andersen-Tawil syndrome: prospective cohort analysis and expansion of the phenotype
    G Yoon
    Department of Pediatrics, Division of Medical Genetics, University of California, San Francisco, California 94143 0748, USA
    Am J Med Genet A 140:312-21. 2006
  10. doi Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density
    John A Jansen
    Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands
    Biochem Biophys Res Commun 367:687-92. 2008

Detail Information

Publications246 found, 100 shown here

  1. ncbi Primary structure and functional expression of a mouse inward rectifier potassium channel
    Y Kubo
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Nature 362:127-33. 1993
    A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning...
  2. ncbi Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome
    N M Plaster
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Cell 105:511-9. 2001
    ..We have mapped an Andersen's locus to chromosome 17q23 near the inward rectifying potassium channel gene KCNJ2. A missense mutation in KCNJ2 (encoding D71V) was identified in the linked family...
  3. pmc Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome
    Regina Preisig-Müller
    Institute of Physiology, Marburg University, Deutschhausstrasse 2, 35037 Marburg, Germany
    Proc Natl Acad Sci U S A 99:7774-9. 2002
    ..Our results suggest that differential tetramerization of the mutant allele of Kir2.1 with wild-type Kir2.1, Kir2.2, and Kir2.3 channels represents the molecular basis of the extraordinary pleiotropy of Andersen's syndrome...
  4. pmc KCNJ2 mutation results in Andersen syndrome with sex-specific cardiac and skeletal muscle phenotypes
    Gregor Andelfinger
    Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, 45229, USA
    Am J Hum Genet 71:663-8. 2002
    Evaluation of candidate loci culminated in the identification of a heterozygous missense mutation (R67W) in KCNJ2, the gene encoding the inward-rectifying potassium current, Kir2...
  5. ncbi A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene
    Silvia G Priori
    Molecular Cardiology, IRCCS Fondazione Maugeri, Pavia, Italy
    Circ Res 96:800-7. 2005
    ..1 (I(K1)) channel. The affected members of a single family had a G514A substitution in the KCNJ2 gene that resulted in a change from aspartic acid to asparagine at position 172 (D172N)...
  6. pmc Mechanism of the voltage sensitivity of IRK1 inward-rectifier K+ channel block by the polyamine spermine
    Hyeon Gyu Shin
    Department of Physiology, University of Pennsylvania, Philadelphia 19104, USA
    J Gen Physiol 125:413-26. 2005
    b>IRK1 (Kir2.1) inward-rectifier K+ channels exhibit exceedingly steep rectification, which reflects strong voltage dependence of channel block by intracellular cations such as the polyamine spermine...
  7. ncbi A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation
    Min Xia
    Institute of Medical Genetics, Tongji University, Shanghai, China
    Biochem Biophys Res Commun 332:1012-9. 2005
    The inward rectifier K(+) channel Kir2.1 mediates the potassium I(K1) current in the heart. It is encoded by KCNJ2 gene that has been linked to Andersen's syndrome. Recently, strong evidences showed that Kir2...
  8. pmc Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels
    Brian K Panama
    University of Michigan, Department of Molecular and Integrative Physiology, Ann Arbor, MI 48109 0622, USA
    J Physiol 571:287-302. 2006
    ..In conclusion, the data are consistent with the universal mechanism of rectification in Kir2 channels, but also point to significant, and physiologically important, quantitative differences between Kir2 isoforms...
  9. ncbi Andersen-Tawil syndrome: prospective cohort analysis and expansion of the phenotype
    G Yoon
    Department of Pediatrics, Division of Medical Genetics, University of California, San Francisco, California 94143 0748, USA
    Am J Med Genet A 140:312-21. 2006
    ..Approximately 70% of patients have mutations in KCNJ2, resulting in dysfunction of the inward-rectifying potassium channel Kir2.1...
  10. doi Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density
    John A Jansen
    Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands
    Biochem Biophys Res Commun 367:687-92. 2008
    ..We conclude that the lysosomal degradation pathway contributes to Kir2.1 mediated inward rectifier current regulation...
  11. doi Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence
    Sabina Benko
    INSERM U 781, Hopital Necker Enfants Malades, Paris, France
    Nat Genet 41:359-64. 2009
    ..Some cases of PRS may thus result from developmental misexpression of SOX9 due to disruption of very-long-range cis-regulatory elements...
  12. doi Inwardly rectifying potassium channels: their structure, function, and physiological roles
    Hiroshi Hibino
    Department of Pharmacology, Graduate School of Medicine and The Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka 565 0871, Japan
    Physiol Rev 90:291-366. 2010
    ..The crystal structure of different Kir channels is opening the way to understanding the structure-function relationships of this simple but diverse ion channel family...
  13. pmc Genome-wide association study reveals multiple loci associated with primary tooth development during infancy
    Demetris Pillas
    Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    PLoS Genet 6:e1000856. 2010
    ..The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3)...
  14. pmc Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate
    Nazzareno D'Avanzo
    Department of Cell Biology and Physiology and the Center for Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 285:37129-32. 2010
    ..This raises the interesting hypothesis that PIP(2) activation of eukaryotic channels reflects an evolutionary adaptation of the channel to the appearance of PIP(2) in the eukaryotic cell membrane...
  15. pmc Dual-mode phospholipid regulation of human inward rectifying potassium channels
    Wayland W L Cheng
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, USA
    Biophys J 100:620-8. 2011
    ..In conclusion, we utilized purified proteins in defined lipid membranes to quantitatively determine the phospholipid requirements for human Kir channel activity...
  16. doi Inhibition of Kir2.1 (KCNJ2) by the AMP-activated protein kinase
    Ioana Alesutan
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, Tubingen, Germany
    Biochem Biophys Res Commun 408:505-10. 2011
    ..Mutations of KCNJ2 encoding Kir2...
  17. pmc Golgi export of the Kir2.1 channel is driven by a trafficking signal located within its tertiary structure
    Donghui Ma
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cell 145:1102-15. 2011
    ..1 reveals a quality control step that couples protein conformation to Golgi export and provides molecular insight into how mutations in Kir2.1 arrest the channels at the Golgi...
  18. pmc Characterization of a novel, dominant negative KCNJ2 mutation associated with Andersen-Tawil syndrome
    Scott B Marrus
    Washington University School of Medicine St Louis, MO, USA
    Channels (Austin) 5:500-9. 2011
    ..Approximately 60% of patients exhibit loss-of-function mutations in KCNJ2, which encodes the inwardly rectifying K(+) channel pore forming subunit Kir2.1...
  19. doi Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3
    Ching Lung Cheung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, China
    Nat Genet 44:1026-9. 2012
    ..3 near KCNJ2 (rs312691: odds ratio (OR) = 3.3; P(meta-analysis) = 1.8 × 10(-14))...
  20. pmc KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia
    Makarand Deo
    Department of Engineering, Norfolk State University, Norfolk, VA 23504, USA
    Proc Natl Acad Sci U S A 110:4291-6. 2013
    We describe a mutation (E299V) in KCNJ2, the gene that encodes the strong inward rectifier K(+) channel protein (Kir2.1), in an 11-y-old boy...
  21. ncbi A sequence motif responsible for ER export and surface expression of Kir2.0 inward rectifier K(+) channels
    C Stockklausner
    Department of Physiology II, University of Tubingen, Ob dem Himmelreich 7, 72074, Tubingen, Germany
    FEBS Lett 493:129-33. 2001
    ..This motif is found to be both necessary and sufficient for efficient export from the ER that eventually leads to efficient surface expression of Kir2.1 channels...
  22. ncbi Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs
    Toru Kobayashi
    Department of Molecular Neuropathology, Brain Research Institute, Niigata University, Niigata, Japan
    Neuropsychopharmacology 29:1841-51. 2004
    ....
  23. pmc Calcium-activated potassium channels and endothelial dysfunction: therapeutic options?
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 156:545-62. 2009
    ..Conversely, blockers of IK(Ca) may prevent restenosis and that of BK(Ca) channels sepsis-dependent hypotension...
  24. ncbi Modulators of G protein-activated inwardly rectifying K+ channels: potentially therapeutic agents for addictive drug users
    Toru Kobayashi
    Department of Molecular Neuropathology, Brain Research Institute, Niigata University, Niigata, Niigata 951 8585, Japan
    Ann N Y Acad Sci 1025:590-4. 2004
    ..Therefore, GIRK channel modulators might be potential agents for the treatment of users of addictive drugs, such as cocaine, opioids, cannabinoids, and ethanol, as well as for the treatment of epilepsy and pain...
  25. ncbi Regulation of a family of inwardly rectifying potassium channels (Kir2) by the m1 muscarinic receptor and the small GTPase Rho
    Todd M Rossignol
    Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Pflugers Arch 452:164-74. 2006
    ..3, implicating a role for calcium in these responses. These results indicate that all three of the Kir2 channels are similarly inhibited by m1 muscarinic receptor stimulation through calcium-dependent activation of the small GTPase Rho...
  26. pmc Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac)
    Toru Kobayashi
    Department of Molecular Neuropathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata, Niigata 951 8585, Japan
    Br J Pharmacol 138:1119-28. 2003
    ..In contrast, ROMK1 and IRK1 channels in other Kir channel subfamilies were insensitive to fluoxetine. 3...
  27. ncbi Molecular basis for genistein-induced inhibition of Kir2.3 currents
    Zhiying Zhao
    Department of Pharmacology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, Hebei 050017, China
    Pflugers Arch 456:413-23. 2008
    ..It was found that the transmembrane domains and the pore region of Kir2.3 channel were important determinant for high sensitivity for genistein inhibition...
  28. doi Physiological role of inward rectifier K(+) channels in vascular smooth muscle cells
    Won Sun Park
    National Research Laboratory for Mitochondrial Signalling, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, 613 735, South Korea
    Pflugers Arch 457:137-47. 2008
    ....
  29. ncbi Regulation of inward rectifier K+ channels by shift of intracellular pH dependence
    Anthony Collins
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331 3507, USA
    J Cell Physiol 202:76-86. 2005
    ..The reduction of inward rectifier K+ channel activity observed in heart failure and ischemia may result from the mitochondrial dysfunction that occurs in these conditions...
  30. ncbi Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function
    Harald Prüss
    Institut fur Anatomie, der Charité, Universitätsklinikum der Humboldt Universität zu Berlin, Philippstrasse 12, D 10115 Berlin, Germany
    Brain Res Mol Brain Res 110:203-19. 2003
    ..The heterogeneous localization of the Kir2.3 and the Kir2.4 subunits with respect to these strategic structures pinpoints to these channel proteins as promising targets for future pharmacological efforts...
  31. pmc Regulation of Kir2.1 channels by the Rho-GTPase, Rac1
    Stephanie B Boyer
    Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA
    J Cell Physiol 218:385-93. 2009
    ..1 in mediating the potentiating effect of Rac1(DN). This novel pathway for regulating surface expression of cardiac Kir2.1 channels could have implications for normal and diseased cardiac states...
  32. ncbi Cloning and functional expression of an inwardly rectifying K+ channel from human atrium
    B A Wible
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030
    Circ Res 76:343-50. 1995
    ..One of the PCR products we obtained was virtually identical to IRK1 (cloned from a mouse macrophage cell line); the other, which we named hIRK, exhibited < 70% identity to IRK1...
  33. ncbi Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma
    C L Huang
    Department of Medicine, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Nature 391:803-6. 1998
    ..inhibitors, PIP2 antibodies potently inhibit each channel with a unique rate (GIRK1/4 approximately GIRK2 >> IRK1 approximately ROMK...
  34. ncbi Multiple promoter elements interact to control the transcription of the potassium channel gene, KCNJ2
    J B Redell
    Department of Pharmacology, and The Virginia Merrill Bloedel Hearing Research Center, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Biol Chem 273:22807-18. 1998
    ..potassium channel family, we have characterized the genomic structure and 5'-proximal promoter of the murine Kcnj2 gene (also referred to as IRK1 and Kir2.1). The Kcnj2 transcription unit is composed of two exons separated by a 5...
  35. pmc Mechanisms for the time-dependent decay of inward currents through cloned Kir2.1 channels expressed in Xenopus oocytes
    R C Shieh
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan, Republic of China
    J Physiol 526:241-52. 2000
    ..These results suggest that the effects of internal Mg2+ and polyamines on Kir2.1 channels involve different binding sites. 6. This study provides evidence for Vm-dependent processes controlling the inactivation of the Kir2.1 channels...
  36. pmc Regulation of gating by negative charges in the cytoplasmic pore in the Kir2.1 channel
    Lai Hua Xie
    Cardiovascular Research Laboratory, Department of Medicine, David Geffen School of Medicine at UCLA, 675 Young Drive South, MRL 3645, Los Angeles, CA 90095, USA
    J Physiol 561:159-68. 2004
    ..1 channels. By suppressing fast gating, these negative charges facilitate polyamine block and unblock, which may be their physiologically important role...
  37. doi Chronic lentiviral expression of inwardly rectifying K+ channels (Kir2.1) reduces neuronal activity and downregulates voltage-gated potassium currents in hippocampus
    M Okada
    Department of Physiology, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Neuroscience 156:289-97. 2008
    ..1 downregulated the expression of the delayed rectifier potassium current in a homeostatic manner, indicating a usefulness of this viral vector to study the activity-dependent neuronal development...
  38. doi Heteromeric assembly of inward rectifier channel subunit Kir2.1 with Kir3.1 and with Kir3.4
    Keiko Ishihara
    Department of Physiology, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Biochem Biophys Res Commun 380:832-7. 2009
    ..1 with the wild-type Kir3.1/3.4 decreased the Kir3.1/3.4 current amplitude in Xenopus oocytes. The results indicate that Kir2.1 is capable of forming heteromultimeric channels with Kir3.1 and with Kir3.4...
  39. ncbi Alternative splicing of human inwardly rectifying K+ channel ROMK1 mRNA
    H Yano
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637
    Mol Pharmacol 45:854-60. 1994
    ..have identified a new family of inwardly rectifying K+ channels, members of which are known by the acronyms ROMK1, IRK1, and GIRK1. We have isolated cDNAs encoding the human homologue of ROMK1 from an adult kidney cDNA library...
  40. ncbi IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain
    C Karschin
    Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Gottingen, Germany
    J Neurosci 16:3559-70. 1996
    ..brain cDNAs, in situ hybridization revealed wide distribution with partly overlapping expression of the mRNAs of IRK1-3 and GIRK1-4...
  41. ncbi Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei
    C Töpert
    Max Planck Institute for Biophysical Chemistry, Molecular Neurobiology of Signal Transduction, 37070 Gottingen, Germany
    J Neurosci 18:4096-105. 1998
    ..The finding that Ba2+-mediated block of Kir2.4 in HMs evokes tonic activity and increases the frequency of induced spike discharge indicates that Kir2.4 channels are of major importance in controlling excitability of motoneurons in situ...
  42. pmc Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels
    P A Slesinger
    The Salk Institute for Biological Studies, Peptide Biology Lab, La Jolla, California 92037, USA
    Biophys J 80:707-18. 2001
    ..I1G1(M) is a chimera of IRK1 (G-protein-insensitive) and GIRK1 and contains the hydrophobic domains (M1-pore-loop-M2) of GIRK1 (G1(M)) with the ..
  43. ncbi Mutation of critical GIRK subunit residues disrupts N- and C-termini association and channel function
    Radmila Sarac
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 25:1836-46. 2005
    ..In addition, the homologous mutation in cytoplasmic domains of Kir2.1 (L330R) did not disrupt association, suggesting that the overall structural integrity of this region is critical for inward rectifier function...
  44. ncbi Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil
    Toru Kobayashi
    Department of Molecular Neuropathology, Brain Research Institute, Niigata University, Niigata, Japan
    Neuropsychopharmacology 31:516-24. 2006
    ..Our results suggest that direct inhibition of GIRK channels by ifenprodil, at submicromolar concentrations or more, may contribute to some of its therapeutic effects and adverse side effects...
  45. doi Novel insights into the structural basis of pH-sensitivity in inward rectifier K+ channels Kir2.3
    Oana N Ureche
    Physiology I, University of Tuebingen, Germany
    Cell Physiol Biochem 21:347-56. 2008
    ..The data provide molecular insight into the unique pH regulation of inward rectifier channels...
  46. pmc Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epithelium
    Dongli Yang
    Department of Ophthalmology and Visual Sciences, University of Michigan, W K Kellogg Eye Center, Ann Arbor, MI 48105 0714, USA
    Exp Eye Res 87:176-83. 2008
    ..Our results indicate that human RPE expresses at least five other Kir channel subtypes in addition to Kir7.1, suggesting that multiple members of the Kir channel family may function in this epithelium...
  47. doi Inward rectifier potassium currents as a target for atrial fibrillation therapy
    Joachim R Ehrlich
    Division of Cardiology, Section of Electrophysiology, J W Goethe Universitat, Frankfurt, Germany
    J Cardiovasc Pharmacol 52:129-35. 2008
    ..The role of I KATP remodeling under AF conditions has not been extensively studied, but present evidence indicates current downregulation and modulation of IKATP seems less promising than that of other inward rectifiers...
  48. ncbi Structural diversity in the cytoplasmic region of G protein-gated inward rectifier K+ channels
    Atsushi Inanobe
    Division of Molecular and Cellular Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Channels (Austin) 1:39-45. 2007
    ..These structural elements are located at the interface with the plasma membrane. Therefore, these structural elements could associate with the Kir channel transmembrane helices and be involved in the regulation of Kir channel gating...
  49. doi Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1
    Xiaojie Yan
    Tianjin Key Laboratory of Protein Science, College of Life Science, Nankai University, Tianjin 300071, China
    J Mol Biol 392:967-76. 2009
    ..3 PDZ-binding motif RRESAI dynamically regulates the Kir2.3/TIP-1 association in heterologous HEK293T cells. These data suggest that TIP-1 may act as an important regulator for the endocytic pathway of Kir2.3...
  50. ncbi Cloning and expression of a novel human brain inward rectifier potassium channel
    E N Makhina
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 269:20468-74. 1994
    ..HRK1 shows sequence similarity to three recently cloned inwardly rectifying potassium channels (IRK1, GIRK1, and ROMK1, 60, 42, and 37%, respectively) and has a similar proposed topology of two membrane spanning ..
  51. ncbi Direct activation of an inwardly rectifying potassium channel by arachidonic acid
    Y Liu
    Icagen, Inc, Durham, North Carolina, USA
    Mol Pharmacol 59:1061-8. 2001
    ..1 and Kir2.3, the transmembrane and/or intracellular domains of Kir2.3 were essential for channel potentiation. These results argue for a direct mechanism of AA modulation of Kir2.3...
  52. pmc The polyamine binding site in inward rectifier K+ channels
    Harley T Kurata
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Gen Physiol 127:467-80. 2006
    ..These data provide physical constraints on the spermine binding site, demonstrating that spermine stably binds at a deep site beyond the "rectification controller" residue, near the extracellular entrance to the channel...
  53. ncbi Trace amines differentially regulate adult locomotor activity, cocaine sensitivity, and female fertility in Drosophila melanogaster
    Shannon L Hardie
    Department of Biology and Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22903, USA
    Dev Neurobiol 67:1396-405. 2007
    ....
  54. ncbi Differential effects of volatile and intravenous anesthetics on the activity of human TASK-1
    C Putzke
    Department of Anesthesiology and Critical Care Medicine, Philipps University Marburg, Baldingerstrasse 1, 35043, Marburg, Germany
    Am J Physiol Cell Physiol 293:C1319-26. 2007
    ..In contrast, stimulatory effects of sevoflurane and enantiomeric isoflurane on human TASK-1 can be observed at clinically relevant concentrations...
  55. pmc Pharmacological manipulation of GABA-driven activity in ovo disrupts the development of dendritic morphology but not the maturation of spinal cord network activity
    Yone J Yoon
    Department of Biology, University of Vermont, Burlington, VT 05405, USA
    Neural Dev 5:11. 2010
    ..In this study, we investigated the role of excitatory GABA-driven activity in regulating the dendritic morphology and network function in the developing chicken spinal cord...
  56. pmc Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block
    Franck C Chatelain
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 4:e7496. 2009
    ....
  57. ncbi Kir potassium channel subunit expression in retinal glial cells: implications for spatial potassium buffering
    Paulo Kofuji
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA
    Glia 39:292-303. 2002
    ..1). The expression of strongly rectifying Kir channels along the "cables" for spatial buffering currents may prevent an unwarranted outward leak of K(+), and, thus, avoid disturbances of neuronal information processing...
  58. ncbi Inward rectifier potassium channels in the basilar artery during chronic alcohol consumption
    Hong Sun
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
    Alcohol Clin Exp Res 28:1557-61. 2004
    ....
  59. ncbi Expression of Kir2.1 and Kir6.2 transgenes under the control of the alpha-MHC promoter in the sinoatrial and atrioventricular nodes in transgenic mice
    H Dobrzynski
    Cardiovascular Research Group, School of Medicine, University of Manchester, Core Technology Facility, 46 Grafton Street, Manchester M13 9NT, UK
    J Mol Cell Cardiol 41:855-67. 2006
    ..The data demonstrate novel transcriptional and/or post-transcriptional control of ion channel subunit expression and raise important questions about the control of regional expression of ion channels...
  60. ncbi Additional gene variants reduce effectiveness of beta-blockers in the LQT1 form of long QT syndrome
    Atsushi Kobori
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Cardiovasc Electrophysiol 15:190-9. 2004
    ..Beta-blockers are widely used to prevent the lethal cardiac events associated with the long QT syndrome (LQTS), especially in KCNQ1-related LQTS (LQT1) patients. Some LQT1 patients, however, are refractory to this therapy...
  61. ncbi Molecular characterization of an inward rectifier channel (IKir) found in avian vestibular hair cells: cloning and expression of pKir2.1
    Manning J Correia
    Department of Otolaryngology, University of Texas Medical Branch, Galveston, Texas 77555 1063, USA
    Physiol Genomics 19:155-69. 2004
    ..1 channels found in pigeon vestibular hair cells were also present in pigeon vestibular nerve, vestibular ganglion, lens, neck muscle, brain (brain stem, cerebellum and optic tectum), liver, and heart...
  62. pmc Pregnenolone sulfate potentiates the inwardly rectifying K channel Kir2.3
    Toru Kobayashi
    Department of Molecular Neuropathology, Brain Research Institute, Niigata University, Niigata, Niigata, Japan
    PLoS ONE 4:e6311. 2009
    ..Among constitutively active Kir2 channels in a major Kir subfamily, Kir2.3 channels are expressed predominantly in the forebrain, a brain area related to cognition, memory, emotion, and neuropsychiatric disorders...
  63. ncbi Correlating phenotype and genotype in the periodic paralyses
    T M Miller
    Department of Neurology, University of California San Francisco 94143 2922, USA
    Neurology 63:1647-55. 2004
    ..one of the classically known mutations, the authors analyzed the entire coding region of the SCN4A, KCNE3, and KCNJ2 genes and portions of the coding region of the CACNA1S gene in order to identify new mutations...
  64. pmc Time-dependent outward currents through the inward rectifier potassium channel IRK1. The role of weak blocking molecules
    K Ishihara
    Department of Physiology, Saga Medical School, Japan
    J Gen Physiol 109:229-43. 1997
    ..The properties of the IRK1 channel expressed in murine fibroblast (L) cells closely resemble those of the native cardiac inward rectifier...
  65. pmc Potassium channel gene mutations rarely cause atrial fibrillation
    Patrick T Ellinor
    Cardiovascular Research Center and Cardiac Arrhythmia Service Massachusetts General Hospital, Boston, Massachusetts, USA
    BMC Med Genet 7:70. 2006
    ..We sought to determine if mutations in KCNJ2 and KCNE1-5 are a common cause of atrial fibrillation.
  66. pmc Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart
    Nathalie Gaborit
    INSERM U533, Nantes, France
    J Physiol 582:675-93. 2007
    ..Concordance with previous functional studies suggests that regional regulation of cardiac ion-current expression may be primarily transcriptional...
  67. doi Ion channel subunit expression changes in cardiac Purkinje fibers: a potential role in conduction abnormalities associated with congestive heart failure
    Ange Maguy
    Department of Medicine, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Circ Res 104:1113-22. 2009
    ....
  68. pmc The intrinsic gating of inward rectifier K+ channels expressed from the murine IRK1 gene depends on voltage, K+ and Mg2+
    P R Stanfield
    Department of Cell Physiology and Pharmacology, University of Leicester
    J Physiol 475:1-7. 1994
    1. We describe the cloning of the inward rectifier K+ channel IRK1 from genomic DNA of mouse; the gene is intronless. 2. The IRK1 gene can be stably expressed in murine erythroleukaemia (MEL) cells...
  69. pmc Susceptibility of cloned K+ channels to reactive oxygen species
    F Duprat
    Institut de Pharmacologie Moleculaire et Cellulaire, Valbonne, France
    Proc Natl Acad Sci U S A 92:11796-800. 1995
    ..2, Shab channels Kv2.1 and Kv2.2, Shal channel Kv4.1, inward rectifiers IRK1 and ROMK1, and hIsK) were completely resistant to this treatment...
  70. ncbi Expression cloning of KCRF, a potassium channel regulatory factor
    T Keren-Raifman
    Department of Physiology and Pharmacology, Sackler School of Medicine, Ramat Aviv, 69978, Israel
    Biochem Biophys Res Commun 274:852-8. 2000
    ..1/K(ir)3.4), inward rectifier IRK1 (K(ir)2.1), and voltage-dependent K(V)1.1/K(V)beta1.1. KCRF did not modulate two other K(+) channels: ROMK1 (K(ir)1...
  71. ncbi Channelopathies: Kir2.1 mutations jeopardize many cell functions
    H J Jongsma
    Department of Medical Physiology, University Medical Center Utrecht, PO Box 85060, 3508 AB Utrecht, The Netherlands
    Curr Biol 11:R747-50. 2001
    ..1, a major determinant of resting membrane potential. The clinical features of this disease illustrate the importance of a stable resting membrane potential for many cell functions...
  72. ncbi Cloning of rabbit Kir6.1, SUR2A, and SUR2B: possible candidates for a renal K(ATP) channel
    Emmanuelle Brochiero
    Groupe de Recherche en Transport Membranaire, Departement de Physiologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    Am J Physiol Renal Physiol 282:F289-300. 2002
    ..x with or without the SUR subunit were significantly inhibited by taurine. This study suggests that the taurine-sensitive K(ATP) channel of rabbit proximal tubules is formed by a combination of Kir6.1 plus SUR2A and/or SUR2B...
  73. ncbi Regulation of cardiac inwardly rectifying potassium channels by membrane lipid metabolism
    Makoto Takano
    Department of Physiology and Biophysics, Graduate School of Medicine, Kyoto University, Japan
    Prog Biophys Mol Biol 81:67-79. 2003
    ..Kir channels in the cardiac myocytes seem to be actively regulated by means of the change in PIP(2) level rather than by downstream signal transduction pathways...
  74. ncbi Muscle biopsy and cell cultures: potential diagnostic tools in hereditary skeletal muscle channelopathies
    G Meola
    Istituto Policlinico San Donato, Dipartimento di Neurologia, Cattedra di Clinica Neurologica, Universita di Milano, Ospedale di San Donato, Italy
    Eur J Histochem 47:17-28. 2003
    ..DNA-based diagnosis is now a reality for many of the channelopathies. This has obvious genetic counselling, prognostic and therapeutic implications...
  75. pmc Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2
    Carsten Zobel
    Departments of Physiology and Medicine, Division of Cardiology, Heart and Stroke Richard Lewar Centre, University Health Network, Toronto, Ontario, Canada
    J Physiol 550:365-72. 2003
    ..Taken together, these results demonstrate functional expression of Kir2.1 and Kir2.2 in rabbit ventricular myocytes and suggest that macroscopic IK1 is predominantly composed of Kir2.1 and Kir2.2 heterotetramers...
  76. pmc Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line
    Keiko Ishihara
    Department of Physiology, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    J Physiol 556:61-78. 2004
    ..Polyamines may regulate the amplitude of the outward I(K1), not only by blocking the channels but also by modifying the proportion of channels that show different sensitivities to the polyamine block...
  77. pmc Characterization of the chicken inward rectifier K+ channel IRK1/Kir2.1 gene
    Hideki Mutai
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    BMC Genomics 5:90. 2004
    ..1. We set out to explore regulatory domains of the cIRK1 promoter that enhance or inhibit expression of the gene in different cell types...
  78. ncbi Glucocorticoid regulation of genes in the amiloride-sensitive sodium transport pathway by semicircular canal duct epithelium of neonatal rat
    Satyanarayana R Pondugula
    Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506 5802, USA
    Physiol Genomics 24:114-23. 2006
    ..These findings are consistent with the genomic stimulation by glucocorticoids of Na+ absorption by SCCD and provide an understanding of the therapeutic action of glucocorticoids in the treatment of Meniere's disease...
  79. ncbi Genotypic heterogeneity and phenotypic mimicry among unrelated patients referred for catecholaminergic polymorphic ventricular tachycardia genetic testing
    David J Tester
    Department of Molecular Pharmacology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Heart Rhythm 3:800-5. 2006
    ..Mutations in the RyR2-encoded cardiac ryanodine receptor/calcium release channel and in CASQ2-encoded calsequestrin cause catecholaminergic polymorphic ventricular tachycardia (CPVT1 and CPVT2, respectively)...
  80. ncbi [Expression of selected genes involved in transport of ions in papillary thyroid carcinoma]
    Monika Gałeza-Kulik
    Department of Nuclear Medicine and Endocrine Oncology, M Sklodowska Curie Cancer Center and Institute of Oncology, Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice
    Endokrynol Pol 57:26-31. 2006
    ..The aim of our study was a real-time PCR evaluation of three of them: KCNJ2, SLC4A4 and SLC34A2.
  81. ncbi Interaction of Galphaq and Kir3, G protein-coupled inwardly rectifying potassium channels
    Takeharu Kawano
    Departments of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Illinois 60612, USA
    Mol Pharmacol 71:1179-84. 2007
    ..These findings agree with the hypothesis (J Physiol 564:489-500, 2005) that the signal to inactivate the Kir3 channel could be mainly transmitted directly from Galpha(q) to Kir3...
  82. ncbi The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
    Baofeng Yang
    Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Harbin Medical University, Harbin, Heilongjiang 150086, China
    Nat Med 13:486-91. 2007
    ..overexpression slowed conduction and depolarized the cytoplasmic membrane by post-transcriptionally repressing KCNJ2 (which encodes the K(+) channel subunit Kir2...
  83. ncbi [Short QT syndrome]
    Christian Wolpert
    Medizinische Klinik, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68259, Mannheim, Germany
    Herz 32:206-10. 2007
    ..To date, different mutations in genes encoding for cardiac ion channels (KCNH2, KCNQ1, and KCNJ2) have been identified to cause the short QT syndrome...
  84. pmc The role of the cytoplasmic pore in inward rectification of Kir2.1 channels
    Harley T Kurata
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Gen Physiol 130:145-55. 2007
    ..The data highlight a "long-pore" effect in Kir channels, and emphasize the importance of considering blocker permeation when assessing the effects of mutations on apparent blocker affinity...
  85. doi Andersen-Tawil syndrome: management challenges during pregnancy, labor, and delivery
    Rajesh N Subbiah
    Arrhythmia Service, Division of Cardiology, University of Western Ontario, Ontario, Canada
    J Cardiovasc Electrophysiol 19:987-9. 2008
    ..It is caused by mutations in the KCNJ2 gene that encodes for the alpha-subunit of Kir2.1, a K(+) channel responsible for cardiac repolarization...
  86. pmc Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol
    Yulia Epshtein
    Department of Medicine, Pulmonary Section, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 106:8055-60. 2009
    ..These findings provide insights into the structural determinants of the sensitivity of Kir2 channels to cholesterol, and introduce the critical role of the cytosolic domain in cholesterol dependent channel regulation...
  87. doi On the mechanism of action of muscle fibre activity in synapse competition and elimination at the mammalian neuromuscular junction
    M Favero
    Section of Physiology, Department of Neurological and Visual Sciences, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Eur J Neurosci 29:2327-34. 2009
    ..1 mutant. Our results are compatible with the interpretation that the block of action potential generation, even in single endplates, can inhibit synapse elimination through local signalling...
  88. pmc High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1
    L Michelle Lewis
    Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mol Pharmacol 76:1094-103. 2009
    ..Electrophysiological analysis indicates that VU590 is an intracellular pore blocker. VU590 and other compounds identified by HTS will be instrumental in defining Kir channel structure, physiology, and therapeutic potential...
  89. pmc Structural bases for the different anti-fibrillatory effects of chloroquine and quinidine
    Sami F Noujaim
    Center for Arrhythmia Research, University of Michigan, 5025 Venture Dr, Ann Arbor, MI 48108, USA
    Cardiovasc Res 89:862-9. 2011
    ..1 makes it a more effective I(K1) blocker and anti-fibrillatory agent than quinidine...
  90. pmc Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells
    Noortje A M Bax
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Mol Med 15:2675-83. 2011
    ..This study shows for the first time the conduction differences between epicardial cells before and after EMT. These differences may be of relevance for the role of EPDCs in cardiac development, and in EMT-related cardiac dysfunction...
  91. pmc Identification and functional characterization of Kir2.6 mutations associated with non-familial hypokalemic periodic paralysis
    Chih Jen Cheng
    Department of Medicine, Division of Nephrology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    J Biol Chem 286:27425-35. 2011
    ..6 predisposes the sarcolemma to hypokalemia-induced paradoxical depolarization during attacks, which in turn leads to Na(+) channel inactivation and inexcitability of muscles...
  92. pmc Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade
    Gillian E Marshall
    Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, 126 University Place, Glasgow, UK
    Pflugers Arch 463:537-48. 2012
    ....
  93. pmc Genetically engineered excitable cardiac myofibroblasts coupled to cardiomyocytes rescue normal propagation and reduce arrhythmia complexity in heterocellular monolayers
    Luqia Hou
    Center for Arrhythmia Research, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e55400. 2013
    ....
  94. pmc Potential use of potassium efflux-deficient yeast for studying trafficking signals and potassium channel functions
    Joshua D Bernstein
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    FEBS Open Bio 3:196-203. 2013
    ....
  95. doi Prolonged leptin treatment increases transient outward K⁺ current via upregulation of Kv4.2 and Kv4.3 channel subunits in adult rat ventricular myocytes
    Nieves Gómez-Hurtado
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid UCM, 28040, Madrid, Spain
    Pflugers Arch 466:903-14. 2014
    ..Altogether these data suggest that leptin could exert beneficial or detrimental effects depending on the initial ventricular myocyte repolarizing reserve...
  96. pmc Focus on Kir7.1: physiology and channelopathy
    Mohit Kumar
    a Departments of Biotechnology and Bioinformatics NIIT University Neemrana, Rajasthan, India
    Channels (Austin) 8:488-95. 2014
    ..Based on the current evidence, mutations implicated in channelopathies have the potential to be used for genetic testing to diagnose blindness due to Kir7.1. ..
  97. pmc The clinical and genetic features in a cohort of mainland Chinese patients with thyrotoxic periodic paralysis
    Xiaobing Li
    Department of Emergency, The First Affiliated Hospital of Nanchang University, Nanchang, China
    BMC Neurol 15:38. 2015
    ..However, potential genetic risk factors for mainland Chinese patients, the largest group of TPP cases in the world, have been largely unexplored...
  98. pmc Structural Basis for Differences in Dynamics Induced by Leu Versus Ile Residues in the CD Loop of Kir Channels
    Shouqin Lü
    Center of Biomechanics and Bioengineering, Institute of Mechanics, Chinese Academy of Sciences, Beijing, 100190, China
    Mol Neurobiol 53:5948-5961. 2016
    ....
  99. doi Intracellular spermine blocks TRPC4 channel via electrostatic interaction with C-terminal negative amino acids
    Jinsung Kim
    College of Medicine, Catholic University of Korea, Seoul, 137 701, Republic of Korea
    Pflugers Arch 468:551-61. 2016
    ....
  100. pmc Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons
    Ji Yong Kang
    Department of Neuroscience, School of Medicine, Tufts University
    J Vis Exp . 2016
    ..The current protocol presents an accessible procedure for intricate Uaa incorporation in neurons in vitro and in vivo to achieve photo control of neuronal protein activity on the molecular level. ..

Research Grants42

  1. Gene-based Neuromodulation: A New Paradigm for Functional Neurosurgery
    Nicholas M Boulis; Fiscal Year: 2012
    ..3) The Rheoswitch(r) inducible expression system will improve controlled LC delivery. 4) Neuronal Kir2.1 gene expression can safely inhibit neuronal activity with potency exceeding that of LC mediated synaptic inhibition. ..
  2. INTERCELLULAR COMMUNICATION AND IMPULSE PROPAGATION
    JOSE S JALIFE; Fiscal Year: 2010
    ..Our main focus is the manner in which the strong inward rectifier Kir2.1 (KCNJ2) and the delayed rectifier HERG (KCHN2) and KyLQT1 (KCNQ1)/mink (KCNE1) modify the ability of cardiac electrical ..
  3. Development of Gene Therapy for Chronic Pain
    David Johns; Fiscal Year: 2005
    ..In conclusion, our proposal will look to combine improved vector development with novel recording techniques to monitor closely the efficacy of gene transfer and to also assess these treatments behaviorally in animals. ..
  4. ASSEMBLY OF INWARD RECTIFIER K CHANNELS
    Kevin Ho; Fiscal Year: 1999
    ..this project will be to understand in detail the oligomerization of inward rectifier K+ channels with the ROMK2 and IRK1 channels as models...
  5. MOLECULAR PHYSIOLOGY OF INWARDLY RECTIFYING K CHANNELS
    Jian Yang; Fiscal Year: 2001
    ..This research project focuses on a strongly rectifying channel, IRK1, that is abundant in both brain and heart...
  6. Eukaryotic Ion Channel Expression for Structural Study
    DANIEL MINOR; Fiscal Year: 2005
    ..The methods developed here are general and, once established, should permit the overproduction of a wide range of ion channels as well as other eukaryotic membrane proteins for biochemical and structural study. ..
  7. LIPID REGULATION OF PURIFIED EUKARYOTIC POTASSIUM CHANNELS
    NAZZARENO D'AVANZO; Fiscal Year: 2012
    ..techniques, 86Rb+ flux assays, electrophysiology, and molecular dynamics simulations, these two specific aims will address the unifying question: What are the molecular determinants and mechanisms by which lipids regulate K+ channels? ..
  8. Inward Rectifier Potassium Channels and Cardiac Excitability
    Anatoli N Lopatin; Fiscal Year: 2010
    ....
  9. Human Bladder Urothelial Cell Structure and Function in Bladder Hypersensation
    Toby C Chai; Fiscal Year: 2010
    ..By accomplishing these aims, we hope to develop an understanding of the pathogenesis of hypersensory bladder conditions which ultimately can lead to targeted treatment options. ..
  10. Novel Role of a Nucleoporin Gene in Atrial Fibrillation, the Most Common Cardiac
    Qing Kenneth Wang; Fiscal Year: 2013
    ..These studies may lead to early diagnosis of AF patients with NUP155 mutations, and new and improved interventions and therapy for AF by targeting NUP155. ..
  11. Sleep promotion in zebrafish by hypocretin neuronal networks
    Philippe Mourrain; Fiscal Year: 2012
    ..abstract_text> ..
  12. Molecular Mechanism Underlying Alcohol Modulation of Inward Rectifying K+ Channel
    Prafulla Aryal; Fiscal Year: 2009
    ..This study could also lead to development of pharmaceutical agents designed to prevent or treat addiction and abuse associated with consumption of alcohol. ..
  13. Wojciech Zareba; Fiscal Year: 2016
    ....
  14. Calcium Triggered Arrhythmias and Sudden Cardiac Arrest
    Richard L Moss; Fiscal Year: 2013
    ..Subproject 2 will investigate the novel observation of KCNJ2 mutations in CPVT and determine the mechanisms by which these mutations current cause CPVT...
  15. Molecular Determinants of Function in Kir2.x channels
    JUSTUS M ANUMONWO; Fiscal Year: 2011
    ..Loss of function in one of the genes (KCNJ2) underlying the channel protein (Kir2...
  16. Melanopsin-expressing retinal ganglion cells: novel genetic tools
    Paulo Kofuji; Fiscal Year: 2009
    ..Determining how the intrinsically photosensitive ganglion cells work may allow the treatment of disorders such as sleep disorders and seasonal depression. ..
  17. Diomedes E Logothetis; Fiscal Year: 2016
    ....
  18. THYROID HORMONE AND CARDIAC SURGERY
    Irwin Klein; Fiscal Year: 2000
    ..2, Kv4.3 and IRK1) that have been linked to atrial rhythm disturbances...
  19. BIOCHEMICALLY DETERMINED TOPOLOGY OF AN RENAL K+ CHANNEL
    RUTH SCHWALBE; Fiscal Year: 2002
    ..proposed to ROMK1; 2) investigate my model's implications for ion conduction; 3) determine whether the topology of IRK1 is similar to ROMK1...
  20. POTASSIUM CHANNELS IN CORNEAL ENDOTHELIUM
    Stephen Ernst; Fiscal Year: 1999
    ..Recently, the applicant and his colleagues have identified a homolog of the inwardly rectifying K+ channel (IRK1) in corneal endothelial cells and have shown the presence of IRK-like channel activity by patch clamp assays...
  21. Studying cardiac IK1 using ion flux assays
    Anatoli Lopatin; Fiscal Year: 2009
    ..1, a gene underlying IK1, were found to be the cause of Long QT (Andersen's) and Short QT (SQT3) syndromes, and familial atrial fibrillation...
  22. K+ CHANNELS STUDIED WITH NOVEL BACKBONE MUTATIONS
    Tao Lu; Fiscal Year: 2000
    ..1 channels. We will examine the effect of the backbone mutations on single-channel kinetics and subconductance levels with either K+ or Tl + as the permeant ion. ..
  23. MECHANISMS OF PERMEATION IN INWARD RECTIFIER K+ CHANNELS
    Zhe Lu; Fiscal Year: 2002
    ..For example, G-protein gated inward-rectifier K+ channels mediate the regulation of heart rate by vagal nerve, and ATP-sensitive inward-rectifier K+ channels are important during cardiac ischemia. (End of Abstract) ..
  24. Development and study of specific Kir channel inhibitors
    Zhe Lu; Fiscal Year: 2009
    ..abstract_text> ..
  25. PROPERTIES OF INWARD RECTIFIER K CHANNELS
    James Weiss; Fiscal Year: 2007
    ..1 (IRK1), the major component of the high[unreadable] resting K conductance in many cell types, and to investigate the ..
  26. Mitochondria and Cardiac Cell Death
    James Weiss; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  27. Afterdepolarizations and Cardiac Arrhythmias
    James N Weiss; Fiscal Year: 2010
    ..S. citizens each year. The goal is to use this information to develop novel therapies to prevent this deadly manifestation of heart disease. ..
  28. Metabolic Oscillations in Heart
    JAMES N contact WEISS; Fiscal Year: 2010
    ..These insights may suggest novel therapies to protect the heart from injury during metabolic stresses such as heart attacks. ..
  29. CARDIAC POTASSIUM CHANNEL SUBUNITS AND SUDDEN DEATH
    Martin Tristani Firouzi; Fiscal Year: 2002
    ..Environment: The University of Utah is a preeminent research institution in the field of cardiac ion channel research and the molecular genetics of LQT. ..
  30. A MICROSURGICAL INVESTIGATION OF GASTRIC ACID SECRETION
    John Geibel; Fiscal Year: 2004
    ..abstract_text> ..
  31. Yeast-Based Screening for Mammalian K Channel Modulators
    ELENA MAKINA; Fiscal Year: 2005
    ..It will also provide leads for future search for highly specific and potent K+ channel modulators for use as neuropharmacological agents. ..
  32. Effects of Abused Inhalants on VTA neurons
    S V Jones; Fiscal Year: 2004
    ....
  33. Kir 3 Channel Subunits in Drug Abuse with GABAB Agonists
    Paul A Slesinger; Fiscal Year: 2010
    ..Such an approach may establish GIRK channels as formidable drug targets for treating addiction. ..
  34. SPATIO-TEMPORAL PERIODICITY IN ARTIAL FIBRILLATION
    JOSE JALIFE; Fiscal Year: 2006
    ..Accomplishment of the proposed studies should lead to an increased understanding of the mechanisms of AF at the molecular, cellular and organ levels and may lead to therapeutic advances. [unreadable] [unreadable]..
  35. Role of Potassium Channels in Fibrillatory Conduction
    JOSE JALIFE; Fiscal Year: 2009
    ..by the recent discovery of two different channelopathies associated with gain-of-function mutations in the KCNJ2 gene that codes for the inward rectifier channel (Kir2...
  36. MOLECULAR CLONING OF EPITHELIAL K CHANNELS
    Henry Sackin; Fiscal Year: 2008
    ..A thorough characterization of their gating is essential for understanding the molecular basis of a variety of channelopathies. ..
  37. High Throughput Screening for Potassium Channel Modulators
    ELENA MAKHINA; Fiscal Year: 2008
    ..Identified compounds will serve both for basic study of K+ channel physiology and as a basis for development of clinical K+ channel drugs. [unreadable] [unreadable] [unreadable]..
  38. Voltage Sensor Movement in the HERG Potassium Channel
    Martin Tristani Firouzi; Fiscal Year: 2008
    ..abstract_text> ..
  39. CELLULAR AND MOLECULAR STUDIES OF VESTIBULAR HAIR CELLS
    MANNING CORREIA; Fiscal Year: 2007
    ..The two specific aims of this project are linked in that one drives studies of the the effector pKir2.1 and the second directs studies the msucarinic receptors in the pathway proposed above. ..
  40. Molecular Mechanisms of Ventricular Fibrillation
    JOSE JALIFE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  41. The Genetic Basis of Atrial Fibrillation
    Patrick Ellinor; Fiscal Year: 2007
    ..Fishman. [] PHS 39812590 (Rev. 05101) Page % Continuation Format Page o Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. ..
  42. Mechanisms of Protein Regulation of Potassium Channels
    PAUL SLESINGER; Fiscal Year: 2006
    ..abstract_text> ..