KCNJ4

Summary

Gene Symbol: KCNJ4
Description: potassium voltage-gated channel subfamily J member 4
Alias: HIR, HIRK2, HRK1, IRK-3, IRK3, Kir2.3, inward rectifier potassium channel 4, hippocampal inward rectifier potassium channel, inward rectifier K(+) channel Kir2.3, potassium channel, inwardly rectifying subfamily J, member 4, potassium inwardly-rectifying channel, subfamily J, member 4
Species: human

Top Publications

  1. ncbi Production and purification of recombinant hirudin expressed in the methylotrophic yeast Pichia pastoris
    S A Rosenfeld
    Cardiovascular Sciences Department, DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880, USA
    Protein Expr Purif 8:476-82. 1996
  2. ncbi Physical demands during an elite female soccer game: importance of training status
    Peter Krustrup
    Institute of Exercise and Sport Sciences, Department of Human Physiology, University of Copenhagen, Denmark
    Med Sci Sports Exerc 37:1242-8. 2005
  3. ncbi [Insulin resistance and islet beta cell function in type 2 diabetes mellitus and non alcoholic fatty liver disease.]
    Fang ping Li
    Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou 510120, China Email
    Zhonghua Nei Ke Za Zhi 48:940-3. 2009
  4. pmc Cloning and characterisation of Schistosoma japonicum insulin receptors
    Hong You
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 5:e9868. 2010
  5. pmc Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus
    F Périer
    Department of Biological Sciences, University of California, Santa Barbara 93106
    Proc Natl Acad Sci U S A 91:6240-4. 1994
  6. doi Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1
    Xiaojie Yan
    Tianjin Key Laboratory of Protein Science, College of Life Science, Nankai University, Tianjin 300071, China
    J Mol Biol 392:967-76. 2009
  7. ncbi Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brain
    Pablo R Perillan
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 277:1974-80. 2002
  8. ncbi Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free system
    J Ahn
    Memorial Sloan Kettering Cancer Center, New York, New York
    J Biol Chem 268:7571-6. 1993
  9. ncbi Identification of two functional estrogen response elements complexed with AP-1-like sites in the human insulin receptor gene promoter
    Moisés García-Arencibia
    Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University, 28040 Madrid, Spain
    J Steroid Biochem Mol Biol 94:1-14. 2005
  10. ncbi The very-low-fluence and high-irradiance responses of the phytochromes have antagonistic effects on germination, mannan-degrading activities, and DfGA3ox transcript levels in Datura ferox seeds
    María Verónica Arana
    IFEVA, Facultad de Agronomia, Universidad de Buenos Aires and CONICET, Avenida San Martin 4453, 1417 Buenos Aires, Argentina
    J Exp Bot 58:3997-4004. 2007

Research Grants

  1. Novel Role of a Nucleoporin Gene in Atrial Fibrillation, the Most Common Cardiac
    Qing Kenneth Wang; Fiscal Year: 2013
  2. Tej K Pandita; Fiscal Year: 2014
  3. MR Spectroscopy to Evaluate Liver Repopulation by Transplanted Hepatocytes
    Chandan Guha; Fiscal Year: 2009
  4. Hepatocyte - Based Therapies of Primary Hyperoxaluria 1
    Namita Roy Chowdhury; Fiscal Year: 2010
  5. Metachromatic Leukodystrophy Enzyme Drug Development
    KA WAI HUI; Fiscal Year: 2012
  6. Ruben J Boado; Fiscal Year: 2014
  7. KA WAI HUI; Fiscal Year: 2014
  8. Enzyme replacement therapy of the brain in Mucopolysaccharidosis Type II
    Zhiqiang Lu; Fiscal Year: 2013
  9. Manufacturing of Trojan Horse-TNFR Decoy Receptor Fusion Protein
    Ruben J Boado; Fiscal Year: 2012
  10. Paul A Welling; Fiscal Year: 2016

Detail Information

Publications227 found, 100 shown here

  1. ncbi Production and purification of recombinant hirudin expressed in the methylotrophic yeast Pichia pastoris
    S A Rosenfeld
    Cardiovascular Sciences Department, DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880, USA
    Protein Expr Purif 8:476-82. 1996
    A recombinant form of hirudin (HIR), a potent thrombin inhibitor derived from the leech Hirudo medicinalis, was cloned and expressed in the methylotrophic yeast Pichia pastoris. The HIR gene was inserted into the P...
  2. ncbi Physical demands during an elite female soccer game: importance of training status
    Peter Krustrup
    Institute of Exercise and Sport Sciences, Department of Human Physiology, University of Copenhagen, Denmark
    Med Sci Sports Exerc 37:1242-8. 2005
    ..To examine the activity profile and physical loading of elite female soccer players during match play and to study the relationship between training status and physical match performance...
  3. ncbi [Insulin resistance and islet beta cell function in type 2 diabetes mellitus and non alcoholic fatty liver disease.]
    Fang ping Li
    Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou 510120, China Email
    Zhonghua Nei Ke Za Zhi 48:940-3. 2009
    ..To investigate insulin resistance and islet beta cell function in type 2 diabetes mellitus (T2DM) and non alcoholic fatty liver disease (NAFLD)...
  4. pmc Cloning and characterisation of Schistosoma japonicum insulin receptors
    Hong You
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 5:e9868. 2010
    ..We cloned and assessed the function of two insulin receptors from Schistosoma japonicum in order to shed light on their role in schistosome biology...
  5. pmc Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus
    F Périer
    Department of Biological Sciences, University of California, Santa Barbara 93106
    Proc Natl Acad Sci U S A 91:6240-4. 1994
    We have isolated a human hippocampus cDNA that encodes an inwardly rectifying potassium channel, termed HIR (hippocampal inward rectifier), with strong rectification characteristics...
  6. doi Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1
    Xiaojie Yan
    Tianjin Key Laboratory of Protein Science, College of Life Science, Nankai University, Tianjin 300071, China
    J Mol Biol 392:967-76. 2009
    ..3 PDZ-binding motif RRESAI dynamically regulates the Kir2.3/TIP-1 association in heterologous HEK293T cells. These data suggest that TIP-1 may act as an important regulator for the endocytic pathway of Kir2.3...
  7. ncbi Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brain
    Pablo R Perillan
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 277:1974-80. 2002
    ..Given the commonality of signaling involving PLC-PKC-delta, we speculate that TGF-beta(1)-evoked depolarization may be an early signaling event related to gene transcription in astrocytes...
  8. ncbi Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free system
    J Ahn
    Memorial Sloan Kettering Cancer Center, New York, New York
    J Biol Chem 268:7571-6. 1993
    The cytoplasmic domain of the human insulin receptor (HIR) from the baculovirus expression system (BIRK) is a soluble, constitutively activated protein-tyrosine kinase...
  9. ncbi Identification of two functional estrogen response elements complexed with AP-1-like sites in the human insulin receptor gene promoter
    Moisés García-Arencibia
    Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University, 28040 Madrid, Spain
    J Steroid Biochem Mol Biol 94:1-14. 2005
    ..to explore the possible existence and location of estrogen response elements (EREs) in the human insulin receptor (hIR) gene promoter...
  10. ncbi The very-low-fluence and high-irradiance responses of the phytochromes have antagonistic effects on germination, mannan-degrading activities, and DfGA3ox transcript levels in Datura ferox seeds
    María Verónica Arana
    IFEVA, Facultad de Agronomia, Universidad de Buenos Aires and CONICET, Avenida San Martin 4453, 1417 Buenos Aires, Argentina
    J Exp Bot 58:3997-4004. 2007
    ..hourly FR pulses during the same period, showing that the antagonistic effect of FRc is a high-irradiance response (HIR)...
  11. ncbi Phytochrome-like responses in Euglena: A low fluence response that reorganizes the spectral dependence of the high irradiance response in long-day photoperiodic induction of cell division
    Aoen Bolige
    Laboratory of Biological Rhythms, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
    J Photochem Photobiol B 86:97-108. 2007
    ..different irradiations for 3h enabled cell division in dark-arrested G2 cells evoking a high-irradiance response (HIR)...
  12. ncbi Protein kinase activity in Cucumis sativus cotyledons: effect of calcium and light
    Dolores Vidal
    Departamento de Biologia Vegetal, Facultad de Biologia, Universidad de Barcelona, 08028 Barcelona, Spain
    Phytochemistry 68:438-45. 2007
    ..75 and 57kDa) with activity of PKs that could be calcium-dependent protein kinases (CDPKs). Both CDPKs could be modulated by phytochromes throughout FR-HIR and VLFR responses.
  13. ncbi The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase
    Michael A Bukys
    Cleveland State University, Department of Chemistry, OH 44115, USA
    Thromb Haemost 99:511-22. 2008
    ..It has been also established that Hir(54-65)(SO(3)(-)) is a specific inhibitor of prothrombinase...
  14. ncbi Immunohistochemical distribution of inwardly rectifying K+ channels in the medulla oblongata of the rat
    Yoshio Yamamoto
    Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University, Morioka, Iwate, Japan
    J Vet Med Sci 70:265-71. 2008
    ..1. Our findings suggest that Kir channels may not act specific to the central chemoreception, but regulate the ionic properties of cellular membranes in various neurons and glial cells...
  15. pmc Pregnenolone sulfate potentiates the inwardly rectifying K channel Kir2.3
    Toru Kobayashi
    Department of Molecular Neuropathology, Brain Research Institute, Niigata University, Niigata, Niigata, Japan
    PLoS ONE 4:e6311. 2009
    ..Among constitutively active Kir2 channels in a major Kir subfamily, Kir2.3 channels are expressed predominantly in the forebrain, a brain area related to cognition, memory, emotion, and neuropsychiatric disorders...
  16. ncbi The roles of platelet-activating factor and endothelin-1 in renal damage after total hepatic ischemia and reperfusion
    S Suzuki
    Department of Surgery II, Hamamatsu University School of Medicine, Japan
    Transplantation 69:2267-73. 2000
    ..involvement of platelet-activating factor (PAF) in renal damage associated with hepatic ischemia and reperfusion (HIR) injury through the release of endothelin (ET)-1 and to determine the modulating effect of a specific PAF receptor ..
  17. ncbi Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing
    J A Sharp
    Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Curr Biol 11:463-73. 2001
    Position-dependent gene silencing in yeast involves many factors, including the four HIR genes and nucleosome assembly proteins Asf1p and chromatin assembly factor I (CAF-I, encoded by the CAC1-3 genes)...
  18. doi The antimalarial drug mefloquine inhibits cardiac inward rectifier K+ channels: evidence for interference in PIP2-channel interaction
    Angélica López-Izquierdo
    Unidad de Investigación Carlos Méndez del Centro Universitario de Investigaciones Biomédicas de la Universidad de Colima, Colima, Col México
    J Cardiovasc Pharmacol 57:407-15. 2011
    ..In inside-out patches, continuous application of PIP2 strikingly prevented the mefloquine inhibition. Our results support the idea that mefloquine interferes with PIP2-Kir channels interactions...
  19. ncbi Kir potassium channel subunit expression in retinal glial cells: implications for spatial potassium buffering
    Paulo Kofuji
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA
    Glia 39:292-303. 2002
    ..1). The expression of strongly rectifying Kir channels along the "cables" for spatial buffering currents may prevent an unwarranted outward leak of K(+), and, thus, avoid disturbances of neuronal information processing...
  20. ncbi Regulation of inward rectifier K+ channels by shift of intracellular pH dependence
    Anthony Collins
    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331 3507, USA
    J Cell Physiol 202:76-86. 2005
    ..The reduction of inward rectifier K+ channel activity observed in heart failure and ischemia may result from the mitochondrial dysfunction that occurs in these conditions...
  21. doi Liver tissue inducible nitric oxide synthase (iNOS) expression and lipid peroxidation in experimental hepatic ischemia reperfusion injury stimulated with lipopolysaccharide: the role of aminoguanidine
    Faik Yaylak
    Department of General Surgery, Dumlupinar University Hospital, Kutahya, Turkey
    J Surg Res 148:214-23. 2008
    Hepatic ischemia-reperfusion (HIR) is a severe condition that is seen after hepatic arterial injury and in hepatic grafts in living donor transplantation...
  22. pmc SAP97 regulates Kir2.3 channels by multiple mechanisms
    Karen L Vikstrom
    Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York, USA
    Am J Physiol Heart Circ Physiol 297:H1387-97. 2009
    ..We further suggest that the SAP97 effect results from SAP97 binding to the Kir2.3 COOH-terminal domain and altering channel conformation...
  23. pmc Characterization of multiple ion channels in cultured human cardiac fibroblasts
    Gui Rong Li
    Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
    PLoS ONE 4:e7307. 2009
    ..The present study was therefore designed to characterize ion channels in cultured human cardiac fibroblasts...
  24. ncbi Managing cetuximab hypersensitivity-infusion reactions: incidence, risk factors, prevention, and retreatment
    Thomas J George
    Department of Medicine, University of Florida Gainesville, Florida 32610 0278, USA
    J Support Oncol 8:72-7. 2010
    ..Limited data regarding risk-reduction interventions for HIR or post-HIR retreatment are available...
  25. pmc Hrk1 plays both Hog1-dependent and -independent roles in controlling stress response and antifungal drug resistance in Cryptococcus neoformans
    Seo Young Kim
    Department of Biotechnology, College of Life Science and Biotechnology, Center for Fungal Pathogenesis, Yonsei University, Seoul, Korea
    PLoS ONE 6:e18769. 2011
    ..Its function is not known in C. neoformans. The present study functionally characterized the role of Hrk1 in C. neoformans. Northern blot analysis confirmed that HRK1 expression depends on the Hog1 MAPK...
  26. ncbi Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2
    K Tobe
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    J Biol Chem 268:11167-71. 1993
    ..tyrosine-phosphorylated proteins in Chinese hamster ovary cells overexpressing human insulin receptors (CHO-HIR cells)...
  27. pmc Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I
    P D Kaufman
    Lawrence Berkeley National Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3206, USA
    Mol Cell Biol 18:4793-806. 1998
    ..In this study, we showed that deletion of HIR genes, which regulate histone gene expression, synergistically reduced gene silencing at telomeres and at the HM ..
  28. pmc Chronic peripheral hyperinsulinemia in type 1 diabetic patients after successful combined pancreas-kidney transplantation does not affect ectopic lipid accumulation in skeletal muscle and liver
    Marietta Stadler
    Hietzing Hospital, 3rd Medical Department of Metabolic Diseases and Nephrology, Vienna, Austria
    Diabetes 59:215-8. 2010
    ....
  29. ncbi Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei
    C Töpert
    Max Planck Institute for Biophysical Chemistry, Molecular Neurobiology of Signal Transduction, 37070 Gottingen, Germany
    J Neurosci 18:4096-105. 1998
    ..The finding that Ba2+-mediated block of Kir2.4 in HMs evokes tonic activity and increases the frequency of induced spike discharge indicates that Kir2.4 channels are of major importance in controlling excitability of motoneurons in situ...
  30. ncbi Two photobiological pathways of phytochrome A activity, only one of which shows dominant negative suppression by phytochrome B
    J J Casal
    IFEVA, Facultad de Agronomia, Universidad de Buenos Aires, Argentina
    Photochem Photobiol 71:481-6. 2000
    ..cotyledon unfolding that require continuous far-red (FR) light for maximum expression (high-irradiance responses, HIR), and responses like seed germination that can be induced by a single pulse of FR (very-low-fluence responses, VLFR)..
  31. ncbi Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brain
    Harald Prüss
    Centrum für Anatomie der Charité, Universitätsklinikum der Humboldt Universität Berlin, Philippstr 12, 10115 Berlin, Germany
    Brain Res Mol Brain Res 139:63-79. 2005
    ..4 than previously determined. In summary, the widespread presence of all four Kir2 channel subunits in the rat brain provides further evidence for their important role in central signal processing and neural transmission...
  32. ncbi High irradiance responses involving photoreversible multiple photoreceptors as related to photoperiodic induction of cell division in Euglena
    Aoen Bolige
    Laboratory of Biological Rhythms, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
    J Photochem Photobiol B 86:109-20. 2007
    ..darkness (DD) when transferred from continuous light (LL); it regulates photoinduction, a high-irradiance response (HIR), of a dark-capability of progressing through cell division. We derived the action spectra by irradiating E...
  33. pmc RXP-E: a connexin43-binding peptide that prevents action potential propagation block
    Rebecca Lewandowski
    Departments of Pharmacology, State University of New York Upstate Medical University, Syracuse, USA
    Circ Res 103:519-26. 2008
    ..RXP-E can be used to characterize the role of gap junctions in the function of multicellular systems, including the heart...
  34. doi HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions
    Colin A Kretz
    Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, Ontario, Canada
    Thromb Haemost 103:83-93. 2010
    ..that HD1 would be a more potent inhibitor of coagulation than other exosite 1-directed ligands, such as Hir(54-65)(SO(3)(-))...
  35. pmc Over-expression of dopamine D2 receptor and inwardly rectifying potassium channel genes in drug-naive schizophrenic peripheral blood lymphocytes as potential diagnostic markers
    Agnes Zvara
    Laboratory of Functional Genomics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Temesvari krt 62, H 6726, Hungary
    Dis Markers 21:61-9. 2005
    ..The use of both molecular markers allows a more rapid and precise prediction of schizophrenia and might help find the optimal medication for schizophrenic patients...
  36. ncbi Selective inhibition of Kir currents by antihistamines
    Boyi Liu
    Department of Pharmacology, Hebei Medical University, China
    Eur J Pharmacol 558:21-6. 2007
    ..The inhibitory effect of antihistamines on Kir currents may be involved in their neuronal and cardiac toxic effects caused by drug overdosing...
  37. pmc Upregulation of inward rectifier K+ (Kir2) channels in dentate gyrus granule cells in temporal lobe epilepsy
    Christina C Young
    Cellular Neurophysiology, Dept of Neurosurgery, University Medical Center Freiburg, Breisacher Str 64, 79106 Freiburg, Germany
    J Physiol 587:4213-33. 2009
    ..These results point to a local adaptive mechanism that could counterbalance hyperexcitability in epilepsy...
  38. ncbi Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function
    Harald Prüss
    Institut fur Anatomie, der Charité, Universitätsklinikum der Humboldt Universität zu Berlin, Philippstrasse 12, D 10115 Berlin, Germany
    Brain Res Mol Brain Res 110:203-19. 2003
    ..The heterogeneous localization of the Kir2.3 and the Kir2.4 subunits with respect to these strategic structures pinpoints to these channel proteins as promising targets for future pharmacological efforts...
  39. ncbi Effects of activation peptide bond cleavage and fragment 2 interactions on the pathway of exosite I expression during activation of human prethrombin 1 to thrombin
    Patricia J Anderson
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 278:44482-8. 2003
    ..in spectroscopic and equilibrium binding studies using the fluorescein-labeled probe, hirudin(54-65) ([5F]Hir(54-65)-(SO3-))...
  40. doi Indices of insulin action calculated from fasting glucose and insulin reflect hepatic, not peripheral, insulin sensitivity in African-American and Caucasian adolescents
    Robert P Hoffman
    Division of Pediatric Endocrinology, Department of Pediatrics, The Clinical Research Center, The Ohio State University College of Medicine and Public Health, Columbus, OH, USA
    Pediatr Diabetes 9:57-61. 2008
    ..relationships of HOMA(IR) and QUICKI to peripheral insulin sensitivity (S(I)(*)) and hepatic insulin resistance (HIR) were assessed in 34 adolescents (age 13.5 +/- 2.9 yr, body mass index 23.0 +/- 5...
  41. ncbi Role of insulin receptor in the regulation of glucose uptake in neonatal hepatocytes
    Carmen Nevado
    Institute of Biochemistry Department of Biochemistry and Molecular Biology, Joint Center Consejo Superior de Investigaciones Científicas Universidad Complutense, School of Pharmacy, Madrid, Spain
    Endocrinology 147:3709-18. 2006
    ..To address this issue, we have generated immortalized neonatal hepatocytes bearing (HIR LoxP) or not (HIR KO) IR...
  42. doi Genetic engineering, expression, and activity of a chimeric monoclonal antibody-avidin fusion protein for receptor-mediated delivery of biotinylated drugs in humans
    Ruben J Boado
    ArmaGen Technologies, Inc, Santa Monica, California 90401, USA
    Bioconjug Chem 19:731-9. 2008
    ..of a fusion protein of avidin (AV) and a chimeric monoclonal antibody (mAb) to the human insulin receptor (HIR) is described. The 15 kDa avidin monomer was fused to the carboxyl terminus of the heavy chain of the HIRMAb...
  43. pmc OWL1: an Arabidopsis J-domain protein involved in perception of very low light fluences
    Julia Kneissl
    Institute of Botany, Department for Biology I, Ludwig Maximilians Universitat, 82152 Planegg Martinsried, Germany
    Plant Cell 21:3212-25. 2009
    ..including both very low fluences (very low fluence response [VLFR]) and high irradiances (high irradiance response [HIR])...
  44. doi Identical sequences but different expression patterns of Hira gene in gynogenetic and gonochoristic crucian carps
    X Z Du
    College of Life Sciences, Central China Normal University, Wuhan 430079, China
    Fish Physiol Biochem 34:175-84. 2008
    b>Hir/Hira (histone regulation) genes were first identified in yeast as negative regulators of histone gene expression. It has been confirmed that HIRA is a conserved family of proteins present in various animals and plants...
  45. pmc Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea-pig cardiomyocytes
    G X Liu
    Institut fur Normale und Pathologische Physiologie, Marburg University Deutschhausstrasse 2, D 35037 Marburg, Germany
    J Physiol 532:115-26. 2001
    ..0 pS) correspond to gpKir2.2. The intermediate-conductance (23.8 pS) and low-conductance (10.7 pS) channels described here may correspond to gpKir2.1 and gpKir2.3, respectively...
  46. ncbi AMPA receptor-mediated modulation of inward rectifier K+ channels in astrocytes of mouse hippocampus
    Wolfgang Schroder
    Experimental Neurobiology, Neurosurgery, University of Bonn, 53105 Bonn, Germany
    Mol Cell Neurosci 19:447-58. 2002
    ..A transient inhibition of I(Kir) in astrocytes in response to neuronal glutamate release and glial AMPA receptor activation represents a further, so far undetected mechanism to balance neuronal excitability...
  47. ncbi Regulation of a family of inwardly rectifying potassium channels (Kir2) by the m1 muscarinic receptor and the small GTPase Rho
    Todd M Rossignol
    Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Pflugers Arch 452:164-74. 2006
    ..3, implicating a role for calcium in these responses. These results indicate that all three of the Kir2 channels are similarly inhibited by m1 muscarinic receptor stimulation through calcium-dependent activation of the small GTPase Rho...
  48. ncbi Kinetics of humoral immune response in pigs vaccinated against foot and mouth disease
    Maitri Sharma
    Department of Veterinary Microbiology, CCS Haryana Agricultural University, Hisar 125 004, India
    Indian J Exp Biol 43:1144-9. 2005
    ..investigation was conducted to study the foot and mouth disease virus (FMDV)-specific humoral immune response (HIR) in pigs, following vaccination with oil adjuvanted foot and mouth disease (FMD) vaccine, upto 90 days post ..
  49. ncbi Towards understanding the schizophrenia code: an expanded convergent functional genomics approach
    H Le-Niculescu
    Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Med Genet B Neuropsychiatr Genet 144:129-58. 2007
    ..GRIA2), one gene involved in neuropeptide signaling (TAC1), two genes involved in synaptic function (SYN2 and KCNJ4), six genes involved in myelin/glial function (CNP, MAL, MBP, PLP1, MOBP and GFAP), and one gene involved in lipid ..
  50. ncbi Efficiency of gene silencing in Arabidopsis: direct inverted repeats vs. transitive RNAi vectors
    Sergei A Filichkin
    Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA
    Plant Biotechnol J 5:615-26. 2007
    ..the efficiency of RNA interference (RNAi) in Arabidopsis using transitive and homologous inverted repeat (hIR) vectors...
  51. ncbi Molecular basis for genistein-induced inhibition of Kir2.3 currents
    Zhiying Zhao
    Department of Pharmacology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, Hebei 050017, China
    Pflugers Arch 456:413-23. 2008
    ..It was found that the transmembrane domains and the pore region of Kir2.3 channel were important determinant for high sensitivity for genistein inhibition...
  52. ncbi Expression of inwardly rectifying K+ channels in the carotid body of rat
    Y Yamamoto
    Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University, Morioka, Japan
    Histol Histopathol 23:799-806. 2008
    ..1, Kir4.1, and Kir5.1 was observed in some ganglion cells. Our findings suggest that Kir channels in the peripheral chemoreceptors play a role in sensing hypercapnic acidosis and maintaining the resting membrane potentials...
  53. doi Immunobiochemical status of sheep exposed to periods of experimental protein deficit and realimentation
    A Sahoo
    Animal Nutrition Division, Indian Veterinary Research Institute, Izatnagar, India
    J Anim Sci 87:2664-73. 2009
    ..At the end of periods 2 and 3, humoral immune response (HIR) was measured by sensitizing the sheep with Brucella abortus S99 antigen and measuring antibody titers on 0, 7, 14, ..
  54. ncbi Potential role of the histone chaperone, CAF-1, in transcription
    Hye Jin Kim
    College of Pharmacy, Sungkyunkwan University, Suwon 440 746, Korea
    BMB Rep 42:227-31. 2009
    ..processes in heterochromatin, whereas Asf1 regulates transcription together with another H3/H4 chaperone, HIR. This study examined the role of the yeast H3/H4 histone chaperones, Asf1, HIR, and CAF-1 in chromatin dynamics ..
  55. pmc IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey
    Ruben J Boado
    ArmaGen Technologies, Inc, Santa Monica, California, USA
    Biotechnol Bioeng 105:627-35. 2010
    ..the Abeta peptide of AD was re-engineered as a fusion protein with the MAb against the human insulin receptor (HIR). The HIRMAb acts as a molecular Trojan horse to ferry the ScFv therapeutic antibody across the BBB...
  56. doi Short intervals between sets and individuality of muscle damage response
    Marco Machado
    Laboratory of Human Movements Studies, University Foundation of Itaperuna FUNITA, Itaperuna, Brazil
    J Strength Cond Res 26:2946-52. 2012
    This study examined creatine kinase (CK) activity after resistance exercise sessions in subjects classified as high (HiR), medium (MeR), or low responders (LoR)...
  57. doi [Spread of Leishmania major to the north of Algeria]
    A Boudrissa
    Institut Pasteur d Algerie, Route du petit Staoueli, Dely Ibrahim, Alger, Algerie
    Bull Soc Pathol Exot 105:30-5. 2012
    ..Recently, a new focus of cutaneous leishmaniasis (CL) has emerged in the village of El M'hir, located on the north side of the chain of the Tell Atlas, in the basin of the Soummam...
  58. doi Postnatal developmental decline in IK1 in mouse ventricular myocytes isolated by the Langendorff perfusion method: comparison with the chunk method
    Shinsuke Hoshino
    Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
    Pflugers Arch 463:649-68. 2012
    ..The present cell isolation method using the Langendorff perfusion thus found that, in mouse ventricles, I (K1) exhibited postnatal developmental decrease, associated with depolarization of resting potential...
  59. doi Imaging amyloid plaque in Alzheimer's disease brain with a biotinylated Aβ peptide radiopharmaceutical conjugated to an IgG-avidin fusion protein
    Rachita K Sumbria
    Department of Medicine, University of Califonia Los Angeles, Los Angeles, California 90024, United States
    Bioconjug Chem 23:1318-21. 2012
    ..protein of avidin (AV) and a genetically engineered monoclonal antibody (mAb) against the human insulin receptor (HIR)...
  60. doi Effect of changes in the deuterium content of drinking water on the hydrogen isotope ratio of urinary steroids in the context of sports drug testing
    Thomas Piper
    Swiss Laboratory for Doping Analysis, University Center of Legal Medicine, Geneva and Lausanne, Centre Hospitalier Universitaire Vaudois and University Lausanne, Epalinges, Switzerland
    Anal Bioanal Chem 405:2911-21. 2013
    The hydrogen isotope ratio (HIR) of body water and, therefore, of all endogenously synthesized compounds in humans, is mainly affected by the HIR of ingested drinking water...
  61. doi Functional expression of a Kir2.1-like inwardly rectifying potassium channel in mouse mammary secretory cells
    Akihiro Kamikawa
    Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    Am J Physiol Cell Physiol 306:C230-40. 2014
    ..1-like channel is expressed in lactating mouse MS cells. We propose that the channel might be involved, at least in part, in secretion and/or preservation of ionic components of milk stored into the lumen of these cells. ..
  62. pmc Adjuvant therapy in early-stage endometrial cancer: a systematic review of the evidence, guidelines, and clinical practice in the U.S
    Nawar A Latif
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, and Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Oncologist 19:645-53. 2014
    ..and PORTEC-2) have shown that the use of adjuvant RT in the intermediate risk (IR) and the high-intermediate risk (HIR) groups decreases locoregional recurrence (LRR) but has no effect on overall survival...
  63. doi Physiological and Movement Demands of Rugby League Referees: Influence on Penalty Accuracy
    Stacey Emmonds
    Research Institute of Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, United Kingdom
    J Strength Cond Res 29:3367-74. 2015
    ..and to determine the relationship between penalty accuracy and total distance covered (TD), high-intensity running (HIR), and heart rate per 10-minute period of match play...
  64. ncbi IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain
    C Karschin
    Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Gottingen, Germany
    J Neurosci 16:3559-70. 1996
    ..IRK1 and IRK3 were restricted to these regions, but they were absent from most parts of the thalamus, cerebellum, and brainstem, ..
  65. ncbi Background potassium channel block and TRPV1 activation contribute to proton depolarization of sensory neurons from humans with neuropathic pain
    Thomas K Baumann
    Martenson Department of Neurological Surgery, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Eur J Neurosci 19:1343-51. 2004
    ..We conclude that in most neurons the sustained depolarization in response to moderately acidic solutions is the result of blocked background potassium channels. In a subset of neurons, TRPV1 also contributes...
  66. pmc Different intracellular polyamine concentrations underlie the difference in the inward rectifier K(+) currents in atria and ventricles of the guinea-pig heart
    Ding Hong Yan
    Department of Physiology, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    J Physiol 563:713-24. 2005
    ..These results strongly suggest that different intracellular polyamine concentrations are responsible for the difference in atrial and ventricular I(K1) of the guinea-pig heart...
  67. ncbi Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function
    Jennifer M Evans
    Division of Molecular Genetics, Faculty of Biomedical and Life Sciences, University of Glasgow, UK
    J Exp Biol 208:3771-83. 2005
    ..abundant and enriched K(+) channel genes encoding the three inward rectifier channels of Drosophila: ir, irk2 and irk3. Enriched expression of inward rectifier channels in tubule was verified by quantitative RT-PCR, and all three IRKs ..
  68. ncbi Antithrombotic action of annexin V proved as efficient as direct inhibition of tissue factor or thrombin
    A M Galan
    Servicio de Hemoterapia y Hemostasia Hospital Clínic, CDB, IDIBAPS, Facultad de Medicina, Barcelona, Spain
    Eur J Clin Invest 36:633-9. 2006
    ..Effects of inhibition of platelet deposition by annexin A5 (ANXA5), hirudin (HIR) or by an antibody against tissue factor (TF) were evaluated. Prothrombin fragment F1 + 2 (F1 + 2) was monitored...
  69. pmc Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropism
    Rosanna Mundy
    Division of Cell and Molecular Biology, Imperial College London, London, UK
    Microbiology 153:959-67. 2007
    ..However, a large body of evidence suggests that intimin also binds a host-cell-encoded receptor(s) (Hir), and interaction of different intimin types with Hir contributes to tissue and host specificity...
  70. ncbi Relationship between Kir2.1/Kir2.3 activity and their distributions between cholesterol-rich and cholesterol-poor membrane domains
    Saloni Tikku
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, USA
    Am J Physiol Cell Physiol 293:C440-50. 2007
    ..Therefore, we suggest that partitioning to membrane rafts plays an important role in the sensitivity of Kir2 channels to cholesterol...
  71. ncbi Variation in top level soccer match performance
    E Rampinini
    Human Performance Laboratory, S S MAPEI srl, Castellanza, Italy
    Int J Sports Med 28:1018-24. 2007
    ..jogging, running, high-speed running and sprinting), distances (total distance [TD], high-intensity running [HIR] and very high-intensity running [VHIR]) and other measures including involvement with the ball and peak running ..
  72. pmc Role of insulin receptor and balance in insulin receptor isoforms A and B in regulation of apoptosis in simian virus 40-immortalized neonatal hepatocytes
    Carmen Nevado
    Departamento de Bioquimica y Biologia Molecular II, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
    Mol Biol Cell 19:1185-98. 2008
    ..Immortalized hepatocytes lacking (HIR KO) or expressing the entire IR (HIR LoxP), and cells expressing either IRA (HIR RecA) or IRB (HIR RecB) have been ..
  73. pmc Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey
    Ruben J Boado
    ArmaGen Technologies, Inc, Santa Monica, California, USA
    Drug Metab Dispos 37:2299-304. 2009
    ..as a fusion protein with a genetically engineered monoclonal antibody (MAb) against the human insulin receptor (HIR), which crosses the BBB on the endogenous insulin receptor...
  74. pmc Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein
    Ruben J Boado
    ArmaGen Technologies, Inc, Santa Monica, CA, United States
    J Biotechnol 146:84-91. 2010
    ..was re-engineered as a fusion protein with a chimeric monoclonal antibody (MAb) against the human insulin receptor (HIR). The HIRMAb acts as a molecular Trojan horse to ferry the TNFR therapeutic decoy receptor across the BBB...
  75. pmc Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of Drosophila
    Lina E Enell
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 5:e15780. 2010
    ..Knockdown of irk3, possibly part of a G protein-activated inwardly rectifying K(+) channel that may link to GBRs, phenocopies GBR ..
  76. doi Carvedilol inhibits Kir2.3 channels by interference with PIP₂-channel interaction
    Tania Ferrer
    Unidad de Investigación Carlos Méndez del Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Mexico
    Eur J Pharmacol 668:72-7. 2011
    ..2% current inhibition). These results suggest that carvedilol, as other cationic amphiphilic drugs, inhibits Kir2.3 channels by interfering with the PIP(2)-channel interaction...
  77. pmc New insights into the genetics of in vivo induction of maternal haploids, the backbone of doubled haploid technology in maize
    Vanessa Prigge
    Institute of Plant Breeding, Seed Science, and Population Genetics, University of Hohenheim, 70593 Stuttgart, Germany
    Genetics 190:781-93. 2012
    ..We determined haploid induction rates (HIR) in testcrosses of a total of 1061 progenies of four segregating populations involving two temperate haploid ..
  78. pmc Dissecting the roles of the histone chaperones reveals the evolutionary conserved mechanism of transcription-coupled deposition of H3.3
    Yunkyoung Song
    School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi do 440 746, Republic of Korea
    Nucleic Acids Res 41:5199-209. 2013
    ..Yeast HIR complex mediated H3-specific recognition specificity for deposition of H3.3 in the transcribed genes...
  79. doi Cardiac CT for planning redo cardiac surgery: effect of knowledge-based iterative model reconstruction on image quality
    Seitaro Oda
    Department of Cardiology, Medstar Washington Hospital Center, 110 Irving Street, NW, Suite 4B 1, Washington, DC, 20010, USA
    Eur Radiol 25:58-64. 2015
    ..model reconstruction (IMR) on image quality in cardiac CT performed for the planning of redo cardiac surgery by comparing IMR images with images reconstructed with filtered back-projection (FBP) and hybrid iterative reconstruction (HIR).
  80. doi An Ir(IV)-containing polyoxometalate
    Sergey A Adonin
    Nikolaev Institute of Inorganic Chemistry SB RAS, 630090 Novosibirsk, Russia
    Chem Commun (Camb) 51:1222-5. 2015
    b>HIr(IV)W6O24](7-), representing the first Ir-containing Anderson-Evans-type polyanion and the first structurally characterized Ir(IV)-based polyoxometalate, has been isolated as its hydrated sodium salt and characterized by single-..
  81. doi Natural course of total mismatch and predictors for tissue infarction
    Benjamin Hotter
    From the Center for Stroke Research Berlin, Charite University Hospital Berlin, Germany
    Neurology 85:770-5. 2015
    We longitudinally assessed patients presenting with total mismatch and hypothesized that hypoperfusion intensity ratio (HIR), severity of stroke, and occlusion of blood vessel are predictors of tissue fate.
  82. ncbi The peak velocity derived from the Carminatti Test is related to physical match performance in young soccer players
    Juliano Fernandes-da-Silva
    a Research Group for Development of Football and Futsal, Sports Center, Federal University of Santa Catarina, Florianopolis, Brazil
    J Sports Sci 34:2238-2245. 2016
    ..78, P < 0.001), high-intensity running (HIR; r = 0.66, P < 0.001), sprinting (r = 0.62, P < 0.001) and total distance (TD) covered (r = 0...
  83. doi The Influence of Iterative Reconstruction on Coronary Artery Calcium Scoring-Phantom and Clinical Studies
    Seitaro Oda
    Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjyo, Chuo Ku, Kumamoto 860 8556, Japan Electronic address
    Acad Radiol . 2016
    We compared the effect of iterative model reconstruction (IMR), filtered back projection (FBP), and hybrid iterative reconstruction (HIR) on coronary artery calcium (CAC) scoring.
  84. pmc Functionally distinct insulin receptors generated by tissue-specific alternative splicing
    L Mosthaf
    Department of Developmental Biology, Genentech, Inc, South San Francisco, CA 90480
    EMBO J 9:2409-13. 1990
    ..encoding the two forms of the insulin receptors are expressed in Rat 1 cells, the receptor lacking the insert (HIR-A) has a significantly higher affinity for insulin than the receptor with the insert (HIR-B)...
  85. pmc Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor
    H deSilva
    Program in Molecular Biology, Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Genetics 148:657-67. 1998
    ..Overexpression of the WD repeats in a hir1delta strain complemented its Hir- phenotype, while overexpression of the C terminus in a wild-type strain caused both Hir- and Spt- phenotypes...
  86. pmc Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteins
    Z Qian
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Mol Cell Biol 18:4783-92. 1998
    ..In addition, the growth rate of the double mutant was reduced. HIR3 belongs to a class of HIR genes that regulate the transcription of histones, while Cac3p, together with Cac1p and Cac2p, forms chromatin ..
  87. ncbi Thermal radiosensitization of human tumour cell lines with different sensitivities to 41.1 degrees C
    M Xu
    Washington University School of Medicine, Mallinckrodt Institute of Radiology, Radiation Oncology Center, St Louis, Missouri 63108, USA
    Int J Hyperthermia 15:279-90. 1999
    ..1 degrees C in NSY cells appeared to be related to both intrinsic heat-induced radiosensitization (HIR) and cell-cycle redistribution at 41.1 degrees C. Incidentally, cells incubated at 41...
  88. ncbi Insulin Induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 Skeletal Muscle Cells Is Mediated by Stat5*
    C L Sadowski
    Departments of Microbiology, Mount Sinai School of Medicine, New York, New York, 10029, USA
    J Biol Chem 276:20703-10. 2001
    ..We can recapitulate robust insulin activation of Stat5 in C2C12 cells by stable overexpression of the human IR (hIR)...
  89. ncbi An alternative approach to the identification of respiratory central chemoreceptors in the brainstem
    C Jiang
    Department of Biology, Georgia State University, 24 Peachtree Center Avenue, Atlanta, GA 30302 4010, USA
    Respir Physiol 129:141-57. 2001
    ..1-Kir5.1 contributes to the CO(2)/pH sensitivity in these neurons. We believe that this line of research intended to identify CO(2) sensing molecules is an important addition to current studies on the CCRs...
  90. ncbi Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K+ channel hKir2.3
    Yi Liu
    Icagen, Inc, 4222 Emperor Boulevard, Suite 460, Durham, NC 27703, USA
    Eur J Pharmacol 435:153-60. 2002
    ..1, Kv1.5, and micro1 Na+ channels. Our results demonstrate that tenidap is a potent opener of hKir2.3 and suggest that it can serve as a valuable pharmacological tool for studying physiological and pathological processes involving Kir2.3...
  91. ncbi Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resection
    Chandan Guha
    Departments of Radiation Oncology, Medicine, Pathology, and Molecular Genetics and The Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY
    Hepatology 36:354-62. 2002
    ..We hypothesized that preparative hepatic irradiation (HIR) should inhibit host hepatocyte proliferation in response to partial hepatectomy (PH)...
  92. ncbi Differential distribution of Kir2.1 and Kir2.3 subunits in canine atrium and ventricle
    Peter Melnyk
    Department of Medicine and Research Center, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada
    Am J Physiol Heart Circ Physiol 283:H1123-33. 2002
    ..1 and Kir2.3 subunits differ in the canine atrium versus ventricle. Overall protein density differences are insufficient to explain I(K1) discrepancies, which may be related to differences in subcellular distribution...
  93. ncbi Beneficial effect of deletion variant of hepatocyte growth factor for impaired hepatic regeneration in the ischemically damaged liver
    Kazuya Okamoto
    Second Department of Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    World J Surg 26:1260-6. 2002
    This study was conducted to determine the influence of hepatic ischemia and reperfusion (HIR) injury on liver regeneration and the effect of the deletion variant of hepatocyte growth factor (dHGF) under these conditions...
  94. ncbi Role of prothrombin fragment 1 in the pathway of regulatory exosite I formation during conversion of human prothrombin to thrombin
    Patricia J Anderson
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 278:44489-95. 2003
    ..binding studies using hirudin(54-65) labeled with 6-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoate ([NBD]Hir(54-65)(SO3-)) or 5-(carboxy)fluorescein ([5F]Hir(54-65)(SO3-))...
  95. ncbi K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes
    Yoshiko Kanezaki
    Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima, Japan
    Endocr J 51:133-44. 2004
    ..is a transgenic mouse expressing the tyrosine kinase-deficient (dominant-negative form of) human insulin receptor (hIR(KM)TG), and which has insulin resistance in muscle and fat...
  96. ncbi Phytochrome A: functional diversity and polymorphism
    V A Sineshchekov
    Biology Department of the M V Lomonosov Moscow State University, Moscow 119899, Russia
    Photochem Photobiol Sci 3:596-607. 2004
    ..PhyA mediates irreversible photoresponses in the very low and high fluence ranges (VLFR and HIR) primarily in the far-red (FR) spectral region, whereas phyB mediates the 'classical' R/FR reversible responses in ..
  97. pmc Evidence that Spt2/Sin1, an HMG-like factor, plays roles in transcription elongation, chromatin structure, and genome stability in Saccharomyces cerevisiae
    Amine Nourani
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Mol Cell Biol 26:1496-509. 2006
    ..spt2Delta and mutations in genes encoding transcription elongation factors, including members of the PAF and HIR/HPC complexes...
  98. pmc TIP-1 has PDZ scaffold antagonist activity
    Christine Alewine
    Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 17:4200-11. 2006
    ..3 channels lacking the PDZ-binding motif. TIP-1 is ubiquitously expressed, raising the possibility that TIP-1 may play a similar role in regulating the expression of other membrane proteins containing a type I PDZ ligand...
  99. ncbi Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier
    Ruben J Boado
    ArmaGen Technologies, Inc, Santa Monica, California 90401, USA
    Biotechnol Bioeng 96:381-91. 2007
    A murine monoclonal antibody (MAb) to the human insulin receptor (HIR) has been engineered for use as a brain drug delivery system for transport across the human blood-brain barrier (BBB)...
  100. ncbi Analysis of physical match performance in English Premier League soccer referees with particular reference to first half and player work rates
    Matthew Weston
    Professional Game Match Officials Limited, The FA Premier League, 30 Gloucester Place, London, UK
    J Sci Med Sport 10:390-7. 2007
    ..5m/s, HIR); 3, average distance from infringements (DI)...
  101. ncbi Human insulin receptor juxtamembrane domain independent insulin signaling
    Akm A Sattar
    Division of Endocrinology, Department of Internal Medicine, Wayne State University School of Medicine, 421 E Canfield Avenue, Detroit, MI 48201 1928, USA
    Cell Biol Int 31:815-24. 2007
    The exon 16-encoded juxtamembrane (JM) domain of human insulin receptor (hIR) harbors the NPEY motif which couples the insulin-activated hIR kinase to downstream signal transduction molecules...

Research Grants27

  1. Novel Role of a Nucleoporin Gene in Atrial Fibrillation, the Most Common Cardiac
    Qing Kenneth Wang; Fiscal Year: 2013
    ..These studies may lead to early diagnosis of AF patients with NUP155 mutations, and new and improved interventions and therapy for AF by targeting NUP155. ..
  2. Tej K Pandita; Fiscal Year: 2014
    ..Therefore, we will determine the mechanistic basis of enhancing heat-mediated radiosensitization (HIR) by inhibiting telomerase and radiation signaling pathways, which result in the tumor growth control...
  3. MR Spectroscopy to Evaluate Liver Repopulation by Transplanted Hepatocytes
    Chandan Guha; Fiscal Year: 2009
    ..In order to develop a clinically feasible protocol for HT, we have explored preparative hepatic irradiation (HIR) for liver repopulation in order to damage the host hepatocytes and permit preferential proliferation of the ..
  4. Hepatocyte - Based Therapies of Primary Hyperoxaluria 1
    Namita Roy Chowdhury; Fiscal Year: 2010
    ..liver by providing proliferative advantage to transplanted hepatocytes, using preparative hepatic X-irradiation (HIR) and expressing hepatocyte growth factor (HGF) as a mitotic stimulant...
  5. Metachromatic Leukodystrophy Enzyme Drug Development
    KA WAI HUI; Fiscal Year: 2012
    ..monoclonal antibody (MAb) against an endogenous BBB peptide receptor, such as the human insulin receptor (HIR)...
  6. Ruben J Boado; Fiscal Year: 2014
    ..The IgG part is a genetically engineered monoclonal antibody (MAb) against the human insulin receptor (HIR). The HIRMAb-TNFR fusion protein is named AGT-110...
  7. KA WAI HUI; Fiscal Year: 2014
    ..peptidomimetic monoclonal antibody (MAb) against an endogenous BBB peptide receptor, the human insulin receptor (HIR)...
  8. Enzyme replacement therapy of the brain in Mucopolysaccharidosis Type II
    Zhiqiang Lu; Fiscal Year: 2013
    ..peptidomimetic monoclonal antibody (MAb) against an endogenous BBB peptide receptor, the human insulin receptor (HIR)...
  9. Manufacturing of Trojan Horse-TNFR Decoy Receptor Fusion Protein
    Ruben J Boado; Fiscal Year: 2012
    ..The IgG part is a genetically engineered monoclonal antibody (MAb) against the human insulin receptor (HIR)...
  10. Paul A Welling; Fiscal Year: 2016
    ....
  11. Patricia I Dickson; Fiscal Year: 2014
    ..The ability of ERT to treat these conditions may be limited by the humoral immune response (HIR) that is produced by the host against the recombinant protein, causing the enzyme to be taken up poorly by host ..
  12. Re-Engineering Blood-Borne Erythropoietin for Targeted Delivery
    Ruben J Boado; Fiscal Year: 2011
    ..The IgG part is a genetically engineered monoclonal antibody (MAb) against the human insulin receptor (HIR)...
  13. Regulation of histone genes upon replication arrest and DNA damage
    HYERYUN PAIK; Fiscal Year: 2007
    ..What are the functional interactions between factors such as Rad53, RSC and the histone regulator Hir complex (which are known to be involved in histone gene regulation), in the downregulation of histone transcript ..
  14. Preparative irradiation for hepatocyte transplantation
    Chandan Guha; Fiscal Year: 2009
    ..to develop a clinically feasible preparative regimen for HT, we have explored preparative hepatic irradiation (HIR) for liver repopulation...
  15. Flavonoids in the Amelioration of Hypertiglyceridemia
    Andre Theriault; Fiscal Year: 2004
    ..We have recently shown that a citrus bioflavonoid administered to hypertriglyceridemic-insulin resistant (HIR) hamsters lowered blood triglyceride levels through the inhibition of hepatic microsomal triglyceride transfer ..
  16. Imaging Brain Amyloid with a Bispecific Antibody
    Yun Zhang; Fiscal Year: 2005
    ..bispecific antibody, wherein one monoclonal antibody (MAb) is a chimeric MAb to the human insulin receptor (HIR), and designated HIRMAb, and the other MAb is a single chain ScFv antibody directed at the Abeta amyloid that forms ..
  17. Vascular KATP Channel Modulation in Hypercapnic Acidosis
    Chun Jiang; Fiscal Year: 2006
    ..abstract_text> ..
  18. Targeted EGFR Antisense Gene Therapy of Brain Cancer
    RUBEN BOADO; Fiscal Year: 2005
    ..The MTH triggers the sequential receptor-mediated transcytosis of the PIL across the BBB, and the receptor-mediated endocytosis of the PIL into the brain cancer cell. ..
  19. KIR channel modulations in hypercapnic acidosis
    Chun Jiang; Fiscal Year: 2004
    ....
  20. Mechanisms of Hemostatic Protease Inhibition by Serpins
    Ingrid M Verhamme; Fiscal Year: 2010
    ..They may facilitate development of novel anticoagulants based on HCII and DS specifically targeted to arterial thrombosis. ..
  21. Neuroprotection in Stroke Drug Development
    RUBEN BOADO; Fiscal Year: 2008
    ..AGT-120 is the first large molecule neuroprotective that has been specifically formulated to cross the BBB in humans following intravenous administration. ..
  22. Stroke neuroprotection with a recombinant fusion protein
    RUBEN BOADO; Fiscal Year: 2007
    ..The completion of the phase II work will enable the preparation of an IND to the FDA for testing of this novel neuroprotective agent in acute stroke in humans. [unreadable] [unreadable] [unreadable] [unreadable]..
  23. LIVE ATTENUATED MULTIPLY DELETED HIV1 VACCINE FOR AIDS
    Ronald Desrosiers; Fiscal Year: 2004
    ..Through these experiments we will begin the understand the mechanisms of protective immunity and what is needed to induce it. ..
  24. Drug development of an Alzheimer's disease brain scan
    RUBEN BOADO; Fiscal Year: 2005
    ..The AD brain scan may allow for the early detection of those individuals at risk for later development of brain amyloid and AD, and allow for early drug therapy. ..
  25. AGE-RELATED CHANGE IN TRIGEMINAL GANGLION EXCITABILITY
    Thomas Baumann; Fiscal Year: 2003
    ..The experiments will contribute to a better understanding of the factors which may contribute to the age-related increase in the incidence of trigeminal neuralgia and other types of oro-facial neuropathic pain. ..
  26. NEUROPHYSIOLOGY OF TRIGEMINAL NEURALGIA
    Thomas Baumann; Fiscal Year: 2002
    ..abstract_text> ..
  27. Targeted Neurotrophin Drug Development in Parkinson's Disease
    RUBEN BOADO; Fiscal Year: 2008
    ..This research will lead to a new neurotrophin treatment of PD, which can be administered by intravenous or subcutaneous administration. [unreadable] [unreadable] [unreadable]..