Genomes and Genes
Gene Symbol: KCNJ4
Description: potassium voltage-gated channel subfamily J member 4
Alias: HIR, HIRK2, HRK1, IRK-3, IRK3, Kir2.3, inward rectifier potassium channel 4, hippocampal inward rectifier potassium channel, inward rectifier K(+) channel Kir2.3, potassium channel, inwardly rectifying subfamily J, member 4, potassium inwardly-rectifying channel, subfamily J, member 4
Publications227 found, 100 shown here
- Production and purification of recombinant hirudin expressed in the methylotrophic yeast Pichia pastorisS A Rosenfeld
Cardiovascular Sciences Department, DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880, USA
Protein Expr Purif 8:476-82. 1996A recombinant form of hirudin (HIR), a potent thrombin inhibitor derived from the leech Hirudo medicinalis, was cloned and expressed in the methylotrophic yeast Pichia pastoris. The HIR gene was inserted into the P...
- Physical demands during an elite female soccer game: importance of training statusPeter Krustrup
Institute of Exercise and Sport Sciences, Department of Human Physiology, University of Copenhagen, Denmark
Med Sci Sports Exerc 37:1242-8. 2005..To examine the activity profile and physical loading of elite female soccer players during match play and to study the relationship between training status and physical match performance...
- [Insulin resistance and islet beta cell function in type 2 diabetes mellitus and non alcoholic fatty liver disease.]Fang ping Li
Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou 510120, China Email
Zhonghua Nei Ke Za Zhi 48:940-3. 2009..To investigate insulin resistance and islet beta cell function in type 2 diabetes mellitus (T2DM) and non alcoholic fatty liver disease (NAFLD)...
- Cloning and characterisation of Schistosoma japonicum insulin receptorsHong You
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
PLoS ONE 5:e9868. 2010..We cloned and assessed the function of two insulin receptors from Schistosoma japonicum in order to shed light on their role in schistosome biology...
- Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampusF Périer
Department of Biological Sciences, University of California, Santa Barbara 93106
Proc Natl Acad Sci U S A 91:6240-4. 1994We have isolated a human hippocampus cDNA that encodes an inwardly rectifying potassium channel, termed HIR (hippocampal inward rectifier), with strong rectification characteristics...
- Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1Xiaojie Yan
Tianjin Key Laboratory of Protein Science, College of Life Science, Nankai University, Tianjin 300071, China
J Mol Biol 392:967-76. 2009..3 PDZ-binding motif RRESAI dynamically regulates the Kir2.3/TIP-1 association in heterologous HEK293T cells. These data suggest that TIP-1 may act as an important regulator for the endocytic pathway of Kir2.3...
- Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brainPablo R Perillan
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 277:1974-80. 2002..Given the commonality of signaling involving PLC-PKC-delta, we speculate that TGF-beta(1)-evoked depolarization may be an early signaling event related to gene transcription in astrocytes...
- Interaction of the human insulin receptor tyrosine kinase from the baculovirus expression system with protein kinase C in a cell-free systemJ Ahn
Memorial Sloan Kettering Cancer Center, New York, New York
J Biol Chem 268:7571-6. 1993The cytoplasmic domain of the human insulin receptor (HIR) from the baculovirus expression system (BIRK) is a soluble, constitutively activated protein-tyrosine kinase...
- Identification of two functional estrogen response elements complexed with AP-1-like sites in the human insulin receptor gene promoterMoisés García-Arencibia
Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University, 28040 Madrid, Spain
J Steroid Biochem Mol Biol 94:1-14. 2005..to explore the possible existence and location of estrogen response elements (EREs) in the human insulin receptor (hIR) gene promoter...
- The very-low-fluence and high-irradiance responses of the phytochromes have antagonistic effects on germination, mannan-degrading activities, and DfGA3ox transcript levels in Datura ferox seedsMaría Verónica Arana
IFEVA, Facultad de Agronomia, Universidad de Buenos Aires and CONICET, Avenida San Martin 4453, 1417 Buenos Aires, Argentina
J Exp Bot 58:3997-4004. 2007..hourly FR pulses during the same period, showing that the antagonistic effect of FRc is a high-irradiance response (HIR)...
- Phytochrome-like responses in Euglena: A low fluence response that reorganizes the spectral dependence of the high irradiance response in long-day photoperiodic induction of cell divisionAoen Bolige
Laboratory of Biological Rhythms, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
J Photochem Photobiol B 86:97-108. 2007..different irradiations for 3h enabled cell division in dark-arrested G2 cells evoking a high-irradiance response (HIR)...
- Protein kinase activity in Cucumis sativus cotyledons: effect of calcium and lightDolores Vidal
Departamento de Biologia Vegetal, Facultad de Biologia, Universidad de Barcelona, 08028 Barcelona, Spain
Phytochemistry 68:438-45. 2007..75 and 57kDa) with activity of PKs that could be calcium-dependent protein kinases (CDPKs). Both CDPKs could be modulated by phytochromes throughout FR-HIR and VLFR responses.
- The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinaseMichael A Bukys
Cleveland State University, Department of Chemistry, OH 44115, USA
Thromb Haemost 99:511-22. 2008..It has been also established that Hir(54-65)(SO(3)(-)) is a specific inhibitor of prothrombinase...
- Immunohistochemical distribution of inwardly rectifying K+ channels in the medulla oblongata of the ratYoshio Yamamoto
Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University, Morioka, Iwate, Japan
J Vet Med Sci 70:265-71. 2008..1. Our findings suggest that Kir channels may not act specific to the central chemoreception, but regulate the ionic properties of cellular membranes in various neurons and glial cells...
- Pregnenolone sulfate potentiates the inwardly rectifying K channel Kir2.3Toru Kobayashi
Department of Molecular Neuropathology, Brain Research Institute, Niigata University, Niigata, Niigata, Japan
PLoS ONE 4:e6311. 2009..Among constitutively active Kir2 channels in a major Kir subfamily, Kir2.3 channels are expressed predominantly in the forebrain, a brain area related to cognition, memory, emotion, and neuropsychiatric disorders...
- The roles of platelet-activating factor and endothelin-1 in renal damage after total hepatic ischemia and reperfusionS Suzuki
Department of Surgery II, Hamamatsu University School of Medicine, Japan
Transplantation 69:2267-73. 2000..involvement of platelet-activating factor (PAF) in renal damage associated with hepatic ischemia and reperfusion (HIR) injury through the release of endothelin (ET)-1 and to determine the modulating effect of a specific PAF receptor ..
- Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencingJ A Sharp
Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Curr Biol 11:463-73. 2001Position-dependent gene silencing in yeast involves many factors, including the four HIR genes and nucleosome assembly proteins Asf1p and chromatin assembly factor I (CAF-I, encoded by the CAC1-3 genes)...
- The antimalarial drug mefloquine inhibits cardiac inward rectifier K+ channels: evidence for interference in PIP2-channel interactionAngélica López-Izquierdo
Unidad de Investigación Carlos Méndez del Centro Universitario de Investigaciones Biomédicas de la Universidad de Colima, Colima, Col México
J Cardiovasc Pharmacol 57:407-15. 2011..In inside-out patches, continuous application of PIP2 strikingly prevented the mefloquine inhibition. Our results support the idea that mefloquine interferes with PIP2-Kir channels interactions...
- Kir potassium channel subunit expression in retinal glial cells: implications for spatial potassium bufferingPaulo Kofuji
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA
Glia 39:292-303. 2002..1). The expression of strongly rectifying Kir channels along the "cables" for spatial buffering currents may prevent an unwarranted outward leak of K(+), and, thus, avoid disturbances of neuronal information processing...
- Regulation of inward rectifier K+ channels by shift of intracellular pH dependenceAnthony Collins
Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331 3507, USA
J Cell Physiol 202:76-86. 2005..The reduction of inward rectifier K+ channel activity observed in heart failure and ischemia may result from the mitochondrial dysfunction that occurs in these conditions...
- Liver tissue inducible nitric oxide synthase (iNOS) expression and lipid peroxidation in experimental hepatic ischemia reperfusion injury stimulated with lipopolysaccharide: the role of aminoguanidineFaik Yaylak
Department of General Surgery, Dumlupinar University Hospital, Kutahya, Turkey
J Surg Res 148:214-23. 2008Hepatic ischemia-reperfusion (HIR) is a severe condition that is seen after hepatic arterial injury and in hepatic grafts in living donor transplantation...
- SAP97 regulates Kir2.3 channels by multiple mechanismsKaren L Vikstrom
Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York, USA
Am J Physiol Heart Circ Physiol 297:H1387-97. 2009..We further suggest that the SAP97 effect results from SAP97 binding to the Kir2.3 COOH-terminal domain and altering channel conformation...
- Characterization of multiple ion channels in cultured human cardiac fibroblastsGui Rong Li
Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
PLoS ONE 4:e7307. 2009..The present study was therefore designed to characterize ion channels in cultured human cardiac fibroblasts...
- Managing cetuximab hypersensitivity-infusion reactions: incidence, risk factors, prevention, and retreatmentThomas J George
Department of Medicine, University of Florida Gainesville, Florida 32610 0278, USA
J Support Oncol 8:72-7. 2010..Limited data regarding risk-reduction interventions for HIR or post-HIR retreatment are available...
- Hrk1 plays both Hog1-dependent and -independent roles in controlling stress response and antifungal drug resistance in Cryptococcus neoformansSeo Young Kim
Department of Biotechnology, College of Life Science and Biotechnology, Center for Fungal Pathogenesis, Yonsei University, Seoul, Korea
PLoS ONE 6:e18769. 2011..Its function is not known in C. neoformans. The present study functionally characterized the role of Hrk1 in C. neoformans. Northern blot analysis confirmed that HRK1 expression depends on the Hog1 MAPK...
- Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2K Tobe
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
J Biol Chem 268:11167-71. 1993..tyrosine-phosphorylated proteins in Chinese hamster ovary cells overexpressing human insulin receptors (CHO-HIR cells)...
- Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor IP D Kaufman
Lawrence Berkeley National Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3206, USA
Mol Cell Biol 18:4793-806. 1998..In this study, we showed that deletion of HIR genes, which regulate histone gene expression, synergistically reduced gene silencing at telomeres and at the HM ..
- Chronic peripheral hyperinsulinemia in type 1 diabetic patients after successful combined pancreas-kidney transplantation does not affect ectopic lipid accumulation in skeletal muscle and liverMarietta Stadler
Hietzing Hospital, 3rd Medical Department of Metabolic Diseases and Nephrology, Vienna, Austria
Diabetes 59:215-8. 2010....
- Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nucleiC Töpert
Max Planck Institute for Biophysical Chemistry, Molecular Neurobiology of Signal Transduction, 37070 Gottingen, Germany
J Neurosci 18:4096-105. 1998..The finding that Ba2+-mediated block of Kir2.4 in HMs evokes tonic activity and increases the frequency of induced spike discharge indicates that Kir2.4 channels are of major importance in controlling excitability of motoneurons in situ...
- Two photobiological pathways of phytochrome A activity, only one of which shows dominant negative suppression by phytochrome BJ J Casal
IFEVA, Facultad de Agronomia, Universidad de Buenos Aires, Argentina
Photochem Photobiol 71:481-6. 2000..cotyledon unfolding that require continuous far-red (FR) light for maximum expression (high-irradiance responses, HIR), and responses like seed germination that can be induced by a single pulse of FR (very-low-fluence responses, VLFR)..
- Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brainHarald Prüss
Centrum für Anatomie der Charité, Universitätsklinikum der Humboldt Universität Berlin, Philippstr 12, 10115 Berlin, Germany
Brain Res Mol Brain Res 139:63-79. 2005..4 than previously determined. In summary, the widespread presence of all four Kir2 channel subunits in the rat brain provides further evidence for their important role in central signal processing and neural transmission...
- High irradiance responses involving photoreversible multiple photoreceptors as related to photoperiodic induction of cell division in EuglenaAoen Bolige
Laboratory of Biological Rhythms, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
J Photochem Photobiol B 86:109-20. 2007..darkness (DD) when transferred from continuous light (LL); it regulates photoinduction, a high-irradiance response (HIR), of a dark-capability of progressing through cell division. We derived the action spectra by irradiating E...
- RXP-E: a connexin43-binding peptide that prevents action potential propagation blockRebecca Lewandowski
Departments of Pharmacology, State University of New York Upstate Medical University, Syracuse, USA
Circ Res 103:519-26. 2008..RXP-E can be used to characterize the role of gap junctions in the function of multicellular systems, including the heart...
- HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactionsColin A Kretz
Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, Ontario, Canada
Thromb Haemost 103:83-93. 2010..that HD1 would be a more potent inhibitor of coagulation than other exosite 1-directed ligands, such as Hir(54-65)(SO(3)(-))...
- Over-expression of dopamine D2 receptor and inwardly rectifying potassium channel genes in drug-naive schizophrenic peripheral blood lymphocytes as potential diagnostic markersAgnes Zvara
Laboratory of Functional Genomics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Temesvari krt 62, H 6726, Hungary
Dis Markers 21:61-9. 2005..The use of both molecular markers allows a more rapid and precise prediction of schizophrenia and might help find the optimal medication for schizophrenic patients...
- Selective inhibition of Kir currents by antihistaminesBoyi Liu
Department of Pharmacology, Hebei Medical University, China
Eur J Pharmacol 558:21-6. 2007..The inhibitory effect of antihistamines on Kir currents may be involved in their neuronal and cardiac toxic effects caused by drug overdosing...
- Upregulation of inward rectifier K+ (Kir2) channels in dentate gyrus granule cells in temporal lobe epilepsyChristina C Young
Cellular Neurophysiology, Dept of Neurosurgery, University Medical Center Freiburg, Breisacher Str 64, 79106 Freiburg, Germany
J Physiol 587:4213-33. 2009..These results point to a local adaptive mechanism that could counterbalance hyperexcitability in epilepsy...
- Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia functionHarald Prüss
Institut fur Anatomie, der Charité, Universitätsklinikum der Humboldt Universität zu Berlin, Philippstrasse 12, D 10115 Berlin, Germany
Brain Res Mol Brain Res 110:203-19. 2003..The heterogeneous localization of the Kir2.3 and the Kir2.4 subunits with respect to these strategic structures pinpoints to these channel proteins as promising targets for future pharmacological efforts...
- Effects of activation peptide bond cleavage and fragment 2 interactions on the pathway of exosite I expression during activation of human prethrombin 1 to thrombinPatricia J Anderson
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 278:44482-8. 2003..in spectroscopic and equilibrium binding studies using the fluorescein-labeled probe, hirudin(54-65) ([5F]Hir(54-65)-(SO3-))...
- Indices of insulin action calculated from fasting glucose and insulin reflect hepatic, not peripheral, insulin sensitivity in African-American and Caucasian adolescentsRobert P Hoffman
Division of Pediatric Endocrinology, Department of Pediatrics, The Clinical Research Center, The Ohio State University College of Medicine and Public Health, Columbus, OH, USA
Pediatr Diabetes 9:57-61. 2008..relationships of HOMA(IR) and QUICKI to peripheral insulin sensitivity (S(I)(*)) and hepatic insulin resistance (HIR) were assessed in 34 adolescents (age 13.5 +/- 2.9 yr, body mass index 23.0 +/- 5...
- Role of insulin receptor in the regulation of glucose uptake in neonatal hepatocytesCarmen Nevado
Institute of Biochemistry Department of Biochemistry and Molecular Biology, Joint Center Consejo Superior de Investigaciones Científicas Universidad Complutense, School of Pharmacy, Madrid, Spain
Endocrinology 147:3709-18. 2006..To address this issue, we have generated immortalized neonatal hepatocytes bearing (HIR LoxP) or not (HIR KO) IR...
- Genetic engineering, expression, and activity of a chimeric monoclonal antibody-avidin fusion protein for receptor-mediated delivery of biotinylated drugs in humansRuben J Boado
ArmaGen Technologies, Inc, Santa Monica, California 90401, USA
Bioconjug Chem 19:731-9. 2008..of a fusion protein of avidin (AV) and a chimeric monoclonal antibody (mAb) to the human insulin receptor (HIR) is described. The 15 kDa avidin monomer was fused to the carboxyl terminus of the heavy chain of the HIRMAb...
- OWL1: an Arabidopsis J-domain protein involved in perception of very low light fluencesJulia Kneissl
Institute of Botany, Department for Biology I, Ludwig Maximilians Universitat, 82152 Planegg Martinsried, Germany
Plant Cell 21:3212-25. 2009..including both very low fluences (very low fluence response [VLFR]) and high irradiances (high irradiance response [HIR])...
- Identical sequences but different expression patterns of Hira gene in gynogenetic and gonochoristic crucian carpsX Z Du
College of Life Sciences, Central China Normal University, Wuhan 430079, China
Fish Physiol Biochem 34:175-84. 2008b>Hir/Hira (histone regulation) genes were first identified in yeast as negative regulators of histone gene expression. It has been confirmed that HIRA is a conserved family of proteins present in various animals and plants...
- Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea-pig cardiomyocytesG X Liu
Institut fur Normale und Pathologische Physiologie, Marburg University Deutschhausstrasse 2, D 35037 Marburg, Germany
J Physiol 532:115-26. 2001..0 pS) correspond to gpKir2.2. The intermediate-conductance (23.8 pS) and low-conductance (10.7 pS) channels described here may correspond to gpKir2.1 and gpKir2.3, respectively...
- AMPA receptor-mediated modulation of inward rectifier K+ channels in astrocytes of mouse hippocampusWolfgang Schroder
Experimental Neurobiology, Neurosurgery, University of Bonn, 53105 Bonn, Germany
Mol Cell Neurosci 19:447-58. 2002..A transient inhibition of I(Kir) in astrocytes in response to neuronal glutamate release and glial AMPA receptor activation represents a further, so far undetected mechanism to balance neuronal excitability...
- Regulation of a family of inwardly rectifying potassium channels (Kir2) by the m1 muscarinic receptor and the small GTPase RhoTodd M Rossignol
Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT 05405, USA
Pflugers Arch 452:164-74. 2006..3, implicating a role for calcium in these responses. These results indicate that all three of the Kir2 channels are similarly inhibited by m1 muscarinic receptor stimulation through calcium-dependent activation of the small GTPase Rho...
- Kinetics of humoral immune response in pigs vaccinated against foot and mouth diseaseMaitri Sharma
Department of Veterinary Microbiology, CCS Haryana Agricultural University, Hisar 125 004, India
Indian J Exp Biol 43:1144-9. 2005..investigation was conducted to study the foot and mouth disease virus (FMDV)-specific humoral immune response (HIR) in pigs, following vaccination with oil adjuvanted foot and mouth disease (FMD) vaccine, upto 90 days post ..
- Towards understanding the schizophrenia code: an expanded convergent functional genomics approachH Le-Niculescu
Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Am J Med Genet B Neuropsychiatr Genet 144:129-58. 2007..GRIA2), one gene involved in neuropeptide signaling (TAC1), two genes involved in synaptic function (SYN2 and KCNJ4), six genes involved in myelin/glial function (CNP, MAL, MBP, PLP1, MOBP and GFAP), and one gene involved in lipid ..
- Efficiency of gene silencing in Arabidopsis: direct inverted repeats vs. transitive RNAi vectorsSergei A Filichkin
Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA
Plant Biotechnol J 5:615-26. 2007..the efficiency of RNA interference (RNAi) in Arabidopsis using transitive and homologous inverted repeat (hIR) vectors...
- Molecular basis for genistein-induced inhibition of Kir2.3 currentsZhiying Zhao
Department of Pharmacology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, Hebei 050017, China
Pflugers Arch 456:413-23. 2008..It was found that the transmembrane domains and the pore region of Kir2.3 channel were important determinant for high sensitivity for genistein inhibition...
- Expression of inwardly rectifying K+ channels in the carotid body of ratY Yamamoto
Laboratory of Veterinary Biochemistry and Cell Biology, Faculty of Agriculture, Iwate University, Morioka, Japan
Histol Histopathol 23:799-806. 2008..1, Kir4.1, and Kir5.1 was observed in some ganglion cells. Our findings suggest that Kir channels in the peripheral chemoreceptors play a role in sensing hypercapnic acidosis and maintaining the resting membrane potentials...
- Immunobiochemical status of sheep exposed to periods of experimental protein deficit and realimentationA Sahoo
Animal Nutrition Division, Indian Veterinary Research Institute, Izatnagar, India
J Anim Sci 87:2664-73. 2009..At the end of periods 2 and 3, humoral immune response (HIR) was measured by sensitizing the sheep with Brucella abortus S99 antigen and measuring antibody titers on 0, 7, 14, ..
- Potential role of the histone chaperone, CAF-1, in transcriptionHye Jin Kim
College of Pharmacy, Sungkyunkwan University, Suwon 440 746, Korea
BMB Rep 42:227-31. 2009..processes in heterochromatin, whereas Asf1 regulates transcription together with another H3/H4 chaperone, HIR. This study examined the role of the yeast H3/H4 histone chaperones, Asf1, HIR, and CAF-1 in chromatin dynamics ..
- IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkeyRuben J Boado
ArmaGen Technologies, Inc, Santa Monica, California, USA
Biotechnol Bioeng 105:627-35. 2010..the Abeta peptide of AD was re-engineered as a fusion protein with the MAb against the human insulin receptor (HIR). The HIRMAb acts as a molecular Trojan horse to ferry the ScFv therapeutic antibody across the BBB...
- Short intervals between sets and individuality of muscle damage responseMarco Machado
Laboratory of Human Movements Studies, University Foundation of Itaperuna FUNITA, Itaperuna, Brazil
J Strength Cond Res 26:2946-52. 2012This study examined creatine kinase (CK) activity after resistance exercise sessions in subjects classified as high (HiR), medium (MeR), or low responders (LoR)...
- [Spread of Leishmania major to the north of Algeria]A Boudrissa
Institut Pasteur d Algerie, Route du petit Staoueli, Dely Ibrahim, Alger, Algerie
Bull Soc Pathol Exot 105:30-5. 2012..Recently, a new focus of cutaneous leishmaniasis (CL) has emerged in the village of El M'hir, located on the north side of the chain of the Tell Atlas, in the basin of the Soummam...
- Postnatal developmental decline in IK1 in mouse ventricular myocytes isolated by the Langendorff perfusion method: comparison with the chunk methodShinsuke Hoshino
Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
Pflugers Arch 463:649-68. 2012..The present cell isolation method using the Langendorff perfusion thus found that, in mouse ventricles, I (K1) exhibited postnatal developmental decrease, associated with depolarization of resting potential...
- Imaging amyloid plaque in Alzheimer's disease brain with a biotinylated Aβ peptide radiopharmaceutical conjugated to an IgG-avidin fusion proteinRachita K Sumbria
Department of Medicine, University of Califonia Los Angeles, Los Angeles, California 90024, United States
Bioconjug Chem 23:1318-21. 2012..protein of avidin (AV) and a genetically engineered monoclonal antibody (mAb) against the human insulin receptor (HIR)...
- Effect of changes in the deuterium content of drinking water on the hydrogen isotope ratio of urinary steroids in the context of sports drug testingThomas Piper
Swiss Laboratory for Doping Analysis, University Center of Legal Medicine, Geneva and Lausanne, Centre Hospitalier Universitaire Vaudois and University Lausanne, Epalinges, Switzerland
Anal Bioanal Chem 405:2911-21. 2013The hydrogen isotope ratio (HIR) of body water and, therefore, of all endogenously synthesized compounds in humans, is mainly affected by the HIR of ingested drinking water...
- Functional expression of a Kir2.1-like inwardly rectifying potassium channel in mouse mammary secretory cellsAkihiro Kamikawa
Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
Am J Physiol Cell Physiol 306:C230-40. 2014..1-like channel is expressed in lactating mouse MS cells. We propose that the channel might be involved, at least in part, in secretion and/or preservation of ionic components of milk stored into the lumen of these cells. ..
- Adjuvant therapy in early-stage endometrial cancer: a systematic review of the evidence, guidelines, and clinical practice in the U.SNawar A Latif
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, and Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Oncologist 19:645-53. 2014..and PORTEC-2) have shown that the use of adjuvant RT in the intermediate risk (IR) and the high-intermediate risk (HIR) groups decreases locoregional recurrence (LRR) but has no effect on overall survival...
- Physiological and Movement Demands of Rugby League Referees: Influence on Penalty AccuracyStacey Emmonds
Research Institute of Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, United Kingdom
J Strength Cond Res 29:3367-74. 2015..and to determine the relationship between penalty accuracy and total distance covered (TD), high-intensity running (HIR), and heart rate per 10-minute period of match play...
- IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brainC Karschin
Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Gottingen, Germany
J Neurosci 16:3559-70. 1996..IRK1 and IRK3 were restricted to these regions, but they were absent from most parts of the thalamus, cerebellum, and brainstem, ..
- Background potassium channel block and TRPV1 activation contribute to proton depolarization of sensory neurons from humans with neuropathic painThomas K Baumann
Martenson Department of Neurological Surgery, Oregon Health and Science University, Portland, OR 97239 3098, USA
Eur J Neurosci 19:1343-51. 2004..We conclude that in most neurons the sustained depolarization in response to moderately acidic solutions is the result of blocked background potassium channels. In a subset of neurons, TRPV1 also contributes...
- Different intracellular polyamine concentrations underlie the difference in the inward rectifier K(+) currents in atria and ventricles of the guinea-pig heartDing Hong Yan
Department of Physiology, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
J Physiol 563:713-24. 2005..These results strongly suggest that different intracellular polyamine concentrations are responsible for the difference in atrial and ventricular I(K1) of the guinea-pig heart...
- Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal functionJennifer M Evans
Division of Molecular Genetics, Faculty of Biomedical and Life Sciences, University of Glasgow, UK
J Exp Biol 208:3771-83. 2005..abundant and enriched K(+) channel genes encoding the three inward rectifier channels of Drosophila: ir, irk2 and irk3. Enriched expression of inward rectifier channels in tubule was verified by quantitative RT-PCR, and all three IRKs ..
- Antithrombotic action of annexin V proved as efficient as direct inhibition of tissue factor or thrombinA M Galan
Servicio de Hemoterapia y Hemostasia Hospital Clínic, CDB, IDIBAPS, Facultad de Medicina, Barcelona, Spain
Eur J Clin Invest 36:633-9. 2006..Effects of inhibition of platelet deposition by annexin A5 (ANXA5), hirudin (HIR) or by an antibody against tissue factor (TF) were evaluated. Prothrombin fragment F1 + 2 (F1 + 2) was monitored...
- Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropismRosanna Mundy
Division of Cell and Molecular Biology, Imperial College London, London, UK
Microbiology 153:959-67. 2007..However, a large body of evidence suggests that intimin also binds a host-cell-encoded receptor(s) (Hir), and interaction of different intimin types with Hir contributes to tissue and host specificity...
- Relationship between Kir2.1/Kir2.3 activity and their distributions between cholesterol-rich and cholesterol-poor membrane domainsSaloni Tikku
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, USA
Am J Physiol Cell Physiol 293:C440-50. 2007..Therefore, we suggest that partitioning to membrane rafts plays an important role in the sensitivity of Kir2 channels to cholesterol...
- Variation in top level soccer match performanceE Rampinini
Human Performance Laboratory, S S MAPEI srl, Castellanza, Italy
Int J Sports Med 28:1018-24. 2007..jogging, running, high-speed running and sprinting), distances (total distance [TD], high-intensity running [HIR] and very high-intensity running [VHIR]) and other measures including involvement with the ball and peak running ..
- Role of insulin receptor and balance in insulin receptor isoforms A and B in regulation of apoptosis in simian virus 40-immortalized neonatal hepatocytesCarmen Nevado
Departamento de Bioquimica y Biologia Molecular II, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain
Mol Biol Cell 19:1185-98. 2008..Immortalized hepatocytes lacking (HIR KO) or expressing the entire IR (HIR LoxP), and cells expressing either IRA (HIR RecA) or IRB (HIR RecB) have been ..
- Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkeyRuben J Boado
ArmaGen Technologies, Inc, Santa Monica, California, USA
Drug Metab Dispos 37:2299-304. 2009..as a fusion protein with a genetically engineered monoclonal antibody (MAb) against the human insulin receptor (HIR), which crosses the BBB on the endogenous insulin receptor...
- Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion proteinRuben J Boado
ArmaGen Technologies, Inc, Santa Monica, CA, United States
J Biotechnol 146:84-91. 2010..was re-engineered as a fusion protein with a chimeric monoclonal antibody (MAb) against the human insulin receptor (HIR). The HIRMAb acts as a molecular Trojan horse to ferry the TNFR therapeutic decoy receptor across the BBB...
- Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of DrosophilaLina E Enell
Department of Zoology, Stockholm University, Stockholm, Sweden
PLoS ONE 5:e15780. 2010..Knockdown of irk3, possibly part of a G protein-activated inwardly rectifying K(+) channel that may link to GBRs, phenocopies GBR ..
- Carvedilol inhibits Kir2.3 channels by interference with PIP₂-channel interactionTania Ferrer
Unidad de Investigación Carlos Méndez del Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Mexico
Eur J Pharmacol 668:72-7. 2011..2% current inhibition). These results suggest that carvedilol, as other cationic amphiphilic drugs, inhibits Kir2.3 channels by interfering with the PIP(2)-channel interaction...
- New insights into the genetics of in vivo induction of maternal haploids, the backbone of doubled haploid technology in maizeVanessa Prigge
Institute of Plant Breeding, Seed Science, and Population Genetics, University of Hohenheim, 70593 Stuttgart, Germany
Genetics 190:781-93. 2012..We determined haploid induction rates (HIR) in testcrosses of a total of 1061 progenies of four segregating populations involving two temperate haploid ..
- Dissecting the roles of the histone chaperones reveals the evolutionary conserved mechanism of transcription-coupled deposition of H3.3Yunkyoung Song
School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi do 440 746, Republic of Korea
Nucleic Acids Res 41:5199-209. 2013..Yeast HIR complex mediated H3-specific recognition specificity for deposition of H3.3 in the transcribed genes...
- Cardiac CT for planning redo cardiac surgery: effect of knowledge-based iterative model reconstruction on image qualitySeitaro Oda
Department of Cardiology, Medstar Washington Hospital Center, 110 Irving Street, NW, Suite 4B 1, Washington, DC, 20010, USA
Eur Radiol 25:58-64. 2015..model reconstruction (IMR) on image quality in cardiac CT performed for the planning of redo cardiac surgery by comparing IMR images with images reconstructed with filtered back-projection (FBP) and hybrid iterative reconstruction (HIR).
- An Ir(IV)-containing polyoxometalateSergey A Adonin
Nikolaev Institute of Inorganic Chemistry SB RAS, 630090 Novosibirsk, Russia
Chem Commun (Camb) 51:1222-5. 2015b>HIr(IV)W6O24](7-), representing the first Ir-containing Anderson-Evans-type polyanion and the first structurally characterized Ir(IV)-based polyoxometalate, has been isolated as its hydrated sodium salt and characterized by single-..
- Natural course of total mismatch and predictors for tissue infarctionBenjamin Hotter
From the Center for Stroke Research Berlin, Charite University Hospital Berlin, Germany
Neurology 85:770-5. 2015We longitudinally assessed patients presenting with total mismatch and hypothesized that hypoperfusion intensity ratio (HIR), severity of stroke, and occlusion of blood vessel are predictors of tissue fate.
- The peak velocity derived from the Carminatti Test is related to physical match performance in young soccer playersJuliano Fernandes-da-Silva
a Research Group for Development of Football and Futsal, Sports Center, Federal University of Santa Catarina, Florianopolis, Brazil
J Sports Sci 34:2238-2245. 2016..78, P < 0.001), high-intensity running (HIR; r = 0.66, P < 0.001), sprinting (r = 0.62, P < 0.001) and total distance (TD) covered (r = 0...
- The Influence of Iterative Reconstruction on Coronary Artery Calcium Scoring-Phantom and Clinical StudiesSeitaro Oda
Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1 1 1 Honjyo, Chuo Ku, Kumamoto 860 8556, Japan Electronic address
Acad Radiol . 2016We compared the effect of iterative model reconstruction (IMR), filtered back projection (FBP), and hybrid iterative reconstruction (HIR) on coronary artery calcium (CAC) scoring.
- Functionally distinct insulin receptors generated by tissue-specific alternative splicingL Mosthaf
Department of Developmental Biology, Genentech, Inc, South San Francisco, CA 90480
EMBO J 9:2409-13. 1990..encoding the two forms of the insulin receptors are expressed in Rat 1 cells, the receptor lacking the insert (HIR-A) has a significantly higher affinity for insulin than the receptor with the insert (HIR-B)...
- Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressorH deSilva
Program in Molecular Biology, Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
Genetics 148:657-67. 1998..Overexpression of the WD repeats in a hir1delta strain complemented its Hir- phenotype, while overexpression of the C terminus in a wild-type strain caused both Hir- and Spt- phenotypes...
- Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteinsZ Qian
Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA
Mol Cell Biol 18:4783-92. 1998..In addition, the growth rate of the double mutant was reduced. HIR3 belongs to a class of HIR genes that regulate the transcription of histones, while Cac3p, together with Cac1p and Cac2p, forms chromatin ..
- Thermal radiosensitization of human tumour cell lines with different sensitivities to 41.1 degrees CM Xu
Washington University School of Medicine, Mallinckrodt Institute of Radiology, Radiation Oncology Center, St Louis, Missouri 63108, USA
Int J Hyperthermia 15:279-90. 1999..1 degrees C in NSY cells appeared to be related to both intrinsic heat-induced radiosensitization (HIR) and cell-cycle redistribution at 41.1 degrees C. Incidentally, cells incubated at 41...
- Insulin Induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 Skeletal Muscle Cells Is Mediated by Stat5*C L Sadowski
Departments of Microbiology, Mount Sinai School of Medicine, New York, New York, 10029, USA
J Biol Chem 276:20703-10. 2001..We can recapitulate robust insulin activation of Stat5 in C2C12 cells by stable overexpression of the human IR (hIR)...
- An alternative approach to the identification of respiratory central chemoreceptors in the brainstemC Jiang
Department of Biology, Georgia State University, 24 Peachtree Center Avenue, Atlanta, GA 30302 4010, USA
Respir Physiol 129:141-57. 2001..1-Kir5.1 contributes to the CO(2)/pH sensitivity in these neurons. We believe that this line of research intended to identify CO(2) sensing molecules is an important addition to current studies on the CCRs...
- Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K+ channel hKir2.3Yi Liu
Icagen, Inc, 4222 Emperor Boulevard, Suite 460, Durham, NC 27703, USA
Eur J Pharmacol 435:153-60. 2002..1, Kv1.5, and micro1 Na+ channels. Our results demonstrate that tenidap is a potent opener of hKir2.3 and suggest that it can serve as a valuable pharmacological tool for studying physiological and pathological processes involving Kir2.3...
- Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resectionChandan Guha
Departments of Radiation Oncology, Medicine, Pathology, and Molecular Genetics and The Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY
Hepatology 36:354-62. 2002..We hypothesized that preparative hepatic irradiation (HIR) should inhibit host hepatocyte proliferation in response to partial hepatectomy (PH)...
- Differential distribution of Kir2.1 and Kir2.3 subunits in canine atrium and ventriclePeter Melnyk
Department of Medicine and Research Center, Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada
Am J Physiol Heart Circ Physiol 283:H1123-33. 2002..1 and Kir2.3 subunits differ in the canine atrium versus ventricle. Overall protein density differences are insufficient to explain I(K1) discrepancies, which may be related to differences in subcellular distribution...
- Beneficial effect of deletion variant of hepatocyte growth factor for impaired hepatic regeneration in the ischemically damaged liverKazuya Okamoto
Second Department of Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
World J Surg 26:1260-6. 2002This study was conducted to determine the influence of hepatic ischemia and reperfusion (HIR) injury on liver regeneration and the effect of the deletion variant of hepatocyte growth factor (dHGF) under these conditions...
- Role of prothrombin fragment 1 in the pathway of regulatory exosite I formation during conversion of human prothrombin to thrombinPatricia J Anderson
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 278:44489-95. 2003..binding studies using hirudin(54-65) labeled with 6-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoate ([NBD]Hir(54-65)(SO3-)) or 5-(carboxy)fluorescein ([5F]Hir(54-65)(SO3-))...
- K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetesYoshiko Kanezaki
Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima, Japan
Endocr J 51:133-44. 2004..is a transgenic mouse expressing the tyrosine kinase-deficient (dominant-negative form of) human insulin receptor (hIR(KM)TG), and which has insulin resistance in muscle and fat...
- Phytochrome A: functional diversity and polymorphismV A Sineshchekov
Biology Department of the M V Lomonosov Moscow State University, Moscow 119899, Russia
Photochem Photobiol Sci 3:596-607. 2004..PhyA mediates irreversible photoresponses in the very low and high fluence ranges (VLFR and HIR) primarily in the far-red (FR) spectral region, whereas phyB mediates the 'classical' R/FR reversible responses in ..
- Evidence that Spt2/Sin1, an HMG-like factor, plays roles in transcription elongation, chromatin structure, and genome stability in Saccharomyces cerevisiaeAmine Nourani
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Mol Cell Biol 26:1496-509. 2006..spt2Delta and mutations in genes encoding transcription elongation factors, including members of the PAF and HIR/HPC complexes...
- TIP-1 has PDZ scaffold antagonist activityChristine Alewine
Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
Mol Biol Cell 17:4200-11. 2006..3 channels lacking the PDZ-binding motif. TIP-1 is ubiquitously expressed, raising the possibility that TIP-1 may play a similar role in regulating the expression of other membrane proteins containing a type I PDZ ligand...
- Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrierRuben J Boado
ArmaGen Technologies, Inc, Santa Monica, California 90401, USA
Biotechnol Bioeng 96:381-91. 2007A murine monoclonal antibody (MAb) to the human insulin receptor (HIR) has been engineered for use as a brain drug delivery system for transport across the human blood-brain barrier (BBB)...
- Analysis of physical match performance in English Premier League soccer referees with particular reference to first half and player work ratesMatthew Weston
Professional Game Match Officials Limited, The FA Premier League, 30 Gloucester Place, London, UK
J Sci Med Sport 10:390-7. 2007..5m/s, HIR); 3, average distance from infringements (DI)...
- Human insulin receptor juxtamembrane domain independent insulin signalingAkm A Sattar
Division of Endocrinology, Department of Internal Medicine, Wayne State University School of Medicine, 421 E Canfield Avenue, Detroit, MI 48201 1928, USA
Cell Biol Int 31:815-24. 2007The exon 16-encoded juxtamembrane (JM) domain of human insulin receptor (hIR) harbors the NPEY motif which couples the insulin-activated hIR kinase to downstream signal transduction molecules...
- Novel Role of a Nucleoporin Gene in Atrial Fibrillation, the Most Common CardiacQing Kenneth Wang; Fiscal Year: 2013..These studies may lead to early diagnosis of AF patients with NUP155 mutations, and new and improved interventions and therapy for AF by targeting NUP155. ..
- Tej K Pandita; Fiscal Year: 2014..Therefore, we will determine the mechanistic basis of enhancing heat-mediated radiosensitization (HIR) by inhibiting telomerase and radiation signaling pathways, which result in the tumor growth control...
- MR Spectroscopy to Evaluate Liver Repopulation by Transplanted HepatocytesChandan Guha; Fiscal Year: 2009..In order to develop a clinically feasible protocol for HT, we have explored preparative hepatic irradiation (HIR) for liver repopulation in order to damage the host hepatocytes and permit preferential proliferation of the ..
- Hepatocyte - Based Therapies of Primary Hyperoxaluria 1Namita Roy Chowdhury; Fiscal Year: 2010..liver by providing proliferative advantage to transplanted hepatocytes, using preparative hepatic X-irradiation (HIR) and expressing hepatocyte growth factor (HGF) as a mitotic stimulant...
- Metachromatic Leukodystrophy Enzyme Drug DevelopmentKA WAI HUI; Fiscal Year: 2012..monoclonal antibody (MAb) against an endogenous BBB peptide receptor, such as the human insulin receptor (HIR)...
- Ruben J Boado; Fiscal Year: 2014..The IgG part is a genetically engineered monoclonal antibody (MAb) against the human insulin receptor (HIR). The HIRMAb-TNFR fusion protein is named AGT-110...
- KA WAI HUI; Fiscal Year: 2014..peptidomimetic monoclonal antibody (MAb) against an endogenous BBB peptide receptor, the human insulin receptor (HIR)...
- Enzyme replacement therapy of the brain in Mucopolysaccharidosis Type IIZhiqiang Lu; Fiscal Year: 2013..peptidomimetic monoclonal antibody (MAb) against an endogenous BBB peptide receptor, the human insulin receptor (HIR)...
- Manufacturing of Trojan Horse-TNFR Decoy Receptor Fusion ProteinRuben J Boado; Fiscal Year: 2012..The IgG part is a genetically engineered monoclonal antibody (MAb) against the human insulin receptor (HIR)...
- Paul A Welling; Fiscal Year: 2016....
- Patricia I Dickson; Fiscal Year: 2014..The ability of ERT to treat these conditions may be limited by the humoral immune response (HIR) that is produced by the host against the recombinant protein, causing the enzyme to be taken up poorly by host ..
- Re-Engineering Blood-Borne Erythropoietin for Targeted DeliveryRuben J Boado; Fiscal Year: 2011..The IgG part is a genetically engineered monoclonal antibody (MAb) against the human insulin receptor (HIR)...
- Regulation of histone genes upon replication arrest and DNA damage HYERYUN PAIK; Fiscal Year: 2007..What are the functional interactions between factors such as Rad53, RSC and the histone regulator Hir complex (which are known to be involved in histone gene regulation), in the downregulation of histone transcript ..
- Preparative irradiation for hepatocyte transplantationChandan Guha; Fiscal Year: 2009..to develop a clinically feasible preparative regimen for HT, we have explored preparative hepatic irradiation (HIR) for liver repopulation...
- Flavonoids in the Amelioration of HypertiglyceridemiaAndre Theriault; Fiscal Year: 2004..We have recently shown that a citrus bioflavonoid administered to hypertriglyceridemic-insulin resistant (HIR) hamsters lowered blood triglyceride levels through the inhibition of hepatic microsomal triglyceride transfer ..
- Imaging Brain Amyloid with a Bispecific AntibodyYun Zhang; Fiscal Year: 2005..bispecific antibody, wherein one monoclonal antibody (MAb) is a chimeric MAb to the human insulin receptor (HIR), and designated HIRMAb, and the other MAb is a single chain ScFv antibody directed at the Abeta amyloid that forms ..
- Vascular KATP Channel Modulation in Hypercapnic AcidosisChun Jiang; Fiscal Year: 2006..abstract_text> ..
- Targeted EGFR Antisense Gene Therapy of Brain CancerRUBEN BOADO; Fiscal Year: 2005..The MTH triggers the sequential receptor-mediated transcytosis of the PIL across the BBB, and the receptor-mediated endocytosis of the PIL into the brain cancer cell. ..
- KIR channel modulations in hypercapnic acidosisChun Jiang; Fiscal Year: 2004....
- Mechanisms of Hemostatic Protease Inhibition by SerpinsIngrid M Verhamme; Fiscal Year: 2010..They may facilitate development of novel anticoagulants based on HCII and DS specifically targeted to arterial thrombosis. ..
- Neuroprotection in Stroke Drug DevelopmentRUBEN BOADO; Fiscal Year: 2008..AGT-120 is the first large molecule neuroprotective that has been specifically formulated to cross the BBB in humans following intravenous administration. ..
- Stroke neuroprotection with a recombinant fusion proteinRUBEN BOADO; Fiscal Year: 2007..The completion of the phase II work will enable the preparation of an IND to the FDA for testing of this novel neuroprotective agent in acute stroke in humans. [unreadable] [unreadable] [unreadable] [unreadable]..
- LIVE ATTENUATED MULTIPLY DELETED HIV1 VACCINE FOR AIDSRonald Desrosiers; Fiscal Year: 2004..Through these experiments we will begin the understand the mechanisms of protective immunity and what is needed to induce it. ..
- Drug development of an Alzheimer's disease brain scanRUBEN BOADO; Fiscal Year: 2005..The AD brain scan may allow for the early detection of those individuals at risk for later development of brain amyloid and AD, and allow for early drug therapy. ..
- AGE-RELATED CHANGE IN TRIGEMINAL GANGLION EXCITABILITYThomas Baumann; Fiscal Year: 2003..The experiments will contribute to a better understanding of the factors which may contribute to the age-related increase in the incidence of trigeminal neuralgia and other types of oro-facial neuropathic pain. ..
- NEUROPHYSIOLOGY OF TRIGEMINAL NEURALGIAThomas Baumann; Fiscal Year: 2002..abstract_text> ..
- Targeted Neurotrophin Drug Development in Parkinson's DiseaseRUBEN BOADO; Fiscal Year: 2008..This research will lead to a new neurotrophin treatment of PD, which can be administered by intravenous or subcutaneous administration. [unreadable] [unreadable] [unreadable]..