Genomes and Genes
Gene Symbol: KCNJ8
Description: potassium voltage-gated channel subfamily J member 8
Alias: KIR6.1, uKATP-1, ATP-sensitive inward rectifier potassium channel 8, inward rectifier K(+) channel Kir6.1, inwardly rectifying potassium channel KIR6.1, potassium channel, inwardly rectifying subfamily J member 8, potassium inwardly-rectifying channel, subfamily J, member 8
Publications207 found, 100 shown here
- A short motif in Kir6.1 consisting of four phosphorylation repeats underlies the vascular KATP channel inhibition by protein kinase CYun Shi
Department of Biology, Georgia State University, 33 Gilmer Street, Atlanta, GA 30302 4010, USA
J Biol Chem 283:2488-94. 2008..1, but not in its close relative Kir6.2, suggests that the vascular K(ATP) channel may have undergone evolutionary optimization, allowing it to be regulated by a variety of vasoconstricting hormones and neurotransmitters...
- Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondriaM Suzuki
Laboratory of Molecular and Cellular Morphology, Gunma University, Japan
Biochem Biophys Res Commun 241:693-7. 1997..1. These results suggest that Kir6.1 might be a subunit of the ATP-sensitive K+ channel in the mitochondrion, as well as in the plasma membrane...
- Loss-of-function mutations in the KCNJ8-encoded Kir6.1 K(ATP) channel and sudden infant death syndromeDavid J Tester
Department of Medicine, Division of Cardiovascular Diseases, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN 55905, USA
Circ Cardiovasc Genet 4:510-5. 2011Approximately 10% of sudden infant death syndrome (SIDS) may stem from cardiac channelopathies. The KCNJ8-encoded Kir6...
- Gain-of-function mutation S422L in the KCNJ8-encoded cardiac K(ATP) channel Kir6.1 as a pathogenic substrate for J-wave syndromesArgelia Medeiros-Domingo
Department of Medicine Division of Cardiovascular Diseases, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA
Heart Rhythm 7:1466-71. 2010..b>KCNJ8, which encodes the cardiac K(ATP) Kir6...
- Interaction with caveolin-1 modulates vascular ATP-sensitive potassium (KATP) channel activityLowri M Davies
Biosciences Building, School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
J Physiol 588:3255-66. 2010..Since caveolin expression is regulated by cellular free cholesterol and plasma levels of low-density lipoprotein (LDL), this interaction may have implications in both the physiological and pathophysiological control of vascular function...
- Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometriumM Curley
National Diagnostics Centre, National University of Ireland, Galway, Ireland
Mol Hum Reprod 8:941-5. 2002..05) were still observed. Our results indicate that the major K(ATP) channel expressed in human myometrium is composed of Kir6.1 and SUR2B, and that down-regulation of this channel may facilitate myometrial function during late pregnancy...
- cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8)N Inagaki
Division of Molecular Medicine, Chiba University School of Medicine, Japan
Genomics 30:102-4. 1995..The human gene encoding uKATP-1, designated KCNJ8, is approximately 9.7 kb in length and is composed of three exons. KCNJ8 was mapped to chromosome 12p11...
- Isoflurane activates sarcolemmal adenosine triphosphate-sensitive potassium channels in vascular smooth muscle cells: a role for protein kinase AKatsuya Tanaka
Department of Anesthesiology, Tokushima University School of Medicine, Kuramoto, Tokushima, Japan
Anesthesiology 106:984-91. 2007..Studies of the interaction of volatile anesthetics with vascular K(ATP) channels have been limited. In the current study, the authors investigated the molecular mechanism of isoflurane's action on vascular K(ATP) channels...
- Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channelsTakashi Kawano
Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan
Anesthesiology 102:93-101. 2005..1 or Kir6.2) and sulfonylurea receptors (SUR1, SUR2A, or SUR2B)...
- Characterization of K(ATP)-channels in rat basilar and middle cerebral arteries: studies of vasomotor responses and mRNA expressionInger Jansen-Olesen
Department of Neurology, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, 2600 Glostrup, Copenhagen, Denmark
Eur J Pharmacol 523:109-18. 2005..1 or Kir6.2. In basilar arteries, but not in middle cerebral arteries, endothelial K(ATP) channels may be involved...
- Expression and function of potassium channels in the human placental vasculatureMark Wareing
Maternal and Fetal Health Research Centre, The University of Manchester, Division of Human Development, St Mary s Hospital, Hathersage Road, Manchester, M13 0JH, UK
Am J Physiol Regul Integr Comp Physiol 291:R437-46. 2006..We conclude that K channels play an important role in controlling placental vascular function...
- Nicorandil and leukocyte activationTakanori Yasu
Department of Integrated Medicine I, Omiya Medical Center, Jichi Medical School, Saitama, Japan
J Cardiovasc Pharmacol 40:684-92. 2002..In conclusion, nicorandil attenuates ischemia/reperfusion-induced PMNL activation via donation of nitric oxide and K channel-related cascade...
- Chronic sustained and intermittent hypoxia reduce function of ATP-sensitive potassium channels in nucleus of the solitary tractWeirong Zhang
Dept of Pharmacology, MSC 7764, UT Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Am J Physiol Regul Integr Comp Physiol 295:R1555-62. 2008..This may represent a neuronal adaptation that preserves neuronal excitability in crucial relay neurons in peripheral chemoreflex pathways...
- A new ATP-sensitive potassium channel opener protects the kidney from hypertensive damage in spontaneously hypertensive ratsHao Xue
Department of Cardiovascular Pharmacology, Beijing Institute of Pharmacology and Toxicology, People s Republic of China
J Pharmacol Exp Ther 315:501-9. 2005....
- The cardiac sarcolemmal ATP-sensitive potassium channel as a novel target for anti-arrhythmic therapyGeorge E Billman
Department of Physiology and Cell Biology, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210 1218, USA
Pharmacol Ther 120:54-70. 2008..Thus, selective antagonists of the cardiac cell surface ATP-sensitive potassium channel may represent a new class of ischemia selective anti-arrhythmic medications...
- Suppressed Ca2+/CaM/CaMKII-dependent K(ATP) channel activity in primary afferent neurons mediates hyperalgesia after axotomyTakashi Kawano
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Proc Natl Acad Sci U S A 106:8725-30. 2009..Unitary current conductance and sensitivity of K(ATP) channels to cytosolic ATP and ligands were preserved even after painful nerve injury, thus providing opportunities for selective therapeutic targeting against neuropathic pain...
- Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidilE Satoh
Department of Pharmacology II, Faculty of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
J Physiol 511:663-74. 1998..5. We conclude that Kir6.0 subunits play a crucial role in the nucleotide-mediated gating of SUR/Kir6.0 complex K+ channels and may determine the molecular mode of pinacidil action...
- Decreased expression of aortic KIR6.1 and SUR2B in hypertension does not correlate with changes in the functional role of K(ATP) channelsJavier Blanco-Rivero
Department of Physiology, School of Medicine, Universidad Autonoma de Madrid, Spain
Eur J Pharmacol 587:204-8. 2008..Our data demonstrate for the first time direct evidence of decreased aortic Kir6.1/SUR2B subunit expression in hypertension, but preserved functional responses to K(ATP) channel openers...
- Phenformin has a direct inhibitory effect on the ATP-sensitive potassium channelQadeer Aziz
Department of Medicine, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, United Kingdom
Eur J Pharmacol 634:26-32. 2010..0 subunit however the sulphonylurea receptor is able to significantly modulate the affinity. It is likely to block from the intracellular side of the channel in a manner analogous to that of PNU 37883A...
- Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidilKatie Shorter
Department of Biomedical Sciences, University of Bradford, Bradford, BD7 1DP, UK
FASEB J 22:1725-36. 2008....
- Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channelM Yamada
Department of Pharmacology II, Faculty of Medicine, Osaka University, Japan
J Physiol 499:715-20. 1997..5. Therefore, the K+ channel composed of SUR2B and Kir6.1 is not a classical ATP-sensitive K+ channel but closely resembles the nucleotide diphosphate-dependent K+ channel in vascular smooth muscle cells...
- Presence and vascular pharmacology of KATP channel subtypes in rat central and peripheral tissuesKenneth Beri Ploug
Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
Eur J Pharmacol 637:109-17. 2010..However, a SUR2B blocker may not discriminate between cranial and peripheral arteries...
- Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in ratS Horinaka
Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan
J Cardiovasc Pharmacol 38:200-10. 2001..Nicorandil appears to enhance cardiac eNOS expression via activation of a K(ATP) channel...
- Pharmacological and molecular comparison of K(ATP) channels in rat basilar and middle cerebral arteriesKenneth Beri Ploug
Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Denmark
Eur J Pharmacol 553:254-62. 2006..Furthermore, the results indicate that Kir6.1/SUR2B is the major K(ATP) channel complex in rat basilar and middle cerebral arteries...
- Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell deathKwok Keung Tai
The Parkinson s and Movement Disorder Institute, Long Beach Memorial Medical Center, 2625 Pasadena Avenue, Long Beach, CA 90806, USA
J Neurochem 84:1193-200. 2003..Taken together, our results demonstrate for the first time that activation of mitochondrial KATP channels elicits protection against rotenone-induced cell death...
- Ca2+/calcineurin regulation of cloned vascular K ATP channels: crosstalk with the protein kinase A pathwayN N Orie
BHF Laboratories, Department of Medicine, University College, London, UK
Br J Pharmacol 157:554-64. 2009..Given that the type-2 regulatory (RII) subunit of PKA is a substrate for calcineurin we considered whether calcineurin regulates channel activity through interacting with PKA...
- [Molecular and functional diversity of ATP-sensitive K+ channels: the pathophysiological roles and potential drug targets]Haruaki Nakaya
Department of Pharmacology, Chiba University Graduate School of Medicine, Japan
Nihon Yakurigaku Zasshi 122:243-50. 2003..Further clarification of physiological as well as pathophysiological roles of K(ATP) channels may lead to a new therapeutic strategy to improve the quality of life...
- Regulation of ENaC and CFTR expression with K+ channel modulators and effect on fluid absorption across alveolar epithelial cellsClaudie Leroy
Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Universite de Montreal, Montreal, Quebec, Canada
Am J Physiol Lung Cell Mol Physiol 291:L1207-19. 2006..Long-term regulation of ENaC and CFTR expression by K(+) channel activity could benefit patients with pulmonary diseases affecting ion transport and fluid clearance...
- Insulin secretion and its modulation by antiarrhythmic and sulfonylurea drugsM Horie
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
Cardiovasc Res 34:69-72. 1997..1 (a putative KATP channel clone)-transfected NIH3T3 cells. Therefore they appear to interact directly with the pore-forming subunit, thereby inhibiting KATP channel currents and exerting an insulinotrophic effect...
- Blockade of cardiac ATP-sensitive K+ channel by cibenzoline targets its pore-forming subunitM Horie
Department of Cardiovascular Medicine, Kyoto University, Graduate School of Medicine, Japan
J Cardiovasc Pharmacol 35:434-42. 2000..Thus cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2), but not the sulfonylurea receptor, from the cytosolic side after it permeates into the cell interior via the membrane lipid bilayer...
- Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneuronesK Lee
Parke Davis Neuroscience Research Centre, Cambridge University Forvie Site, UK
J Physiol 510:441-53. 1998..1 and SUR1 but not Kir6.2 or SUR2. 6. It is concluded that cholinergic interneurones within the rat striatum exhibit a KATP channel current and that this channel is formed from Kir6.1 and SUR1 subunits...
- Expression and function of ATP-dependent potassium channels in late post-infarction remodelingNadia Isidoro Tavares
Division of Cardiology, Geneva University Hospitals, 24 Micheli du Crest, 1211 Geneva 14, Switzerland
J Mol Cell Cardiol 42:1016-25. 2007..Drugs selectively activating diazoxide-sensitive sarcolemmal K(ATP) channels should be considered in the prevention of arrhythmias in post-infarction heart failure...
- K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS productionJuan Xie
Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, People s Republic of China
J Neurosci Res 88:428-37. 2010..Consequently, opening of K(ATP) channels expressed in neurons could protect primary mesencephalic neurons against MPP(+)-induced cytotoxicity via inhibiting ROS overproduction and subsequently ameliorating mitochondrial function...
- KATP channel subunits are expressed in the epididymal epithelium in several mammalian speciesPascale Lybaert
Laboratory of Experimental Hormonology, Faculty of Medicine, Universite Libre de Bruxelles ULB, B 1070 Brussels, Belgium
Biol Reprod 79:253-61. 2008..No immunostaining could be demonstrated for Kir6.1 (KCNJ8) and SUR1 (ABCC8) subunits. Under higher magnification, the immunostaining for Kir6...
- [Effects of Guanxinkang on expressions of ATP-sensitive potassium channel subunits Kir6.1, Kir6.2, SUR2A and SUR2B in ischemic myocytes of rats]Fu Rong Chen
Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Zhong Xi Yi Jie He Xue Bao 8:458-64. 2010....
- ATP-sensitive K+ channels in pig urethral smooth muscle cells are heteromultimers of Kir6.1 and Kir6.2Noriyoshi Teramoto
Dept of Pharmacology, Graduate School of Medical Sciences, Kyushu Univ, 3 1 1 Maidashi, Higashi Ward, Fukuoka, 812 8582, Japan
Am J Physiol Renal Physiol 296:F107-17. 2009..1 channels of vascular myocytes and is responsible for the differences in inward rectification, conductance, and PKC regulation exhibited by the channels in these smooth muscle cell types...
- Gender-specific difference in cardiac ATP-sensitive K(+) channelsH J Ranki
Tayside Institute of Child Health, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
J Am Coll Cardiol 38:906-15. 2001....
- The molecular composition of K(ATP) channels in human pulmonary artery smooth muscle cells and their modulation by growthYi Cui
Centre for Clinical Pharmacology, Department of Medicine, Rayne Institute, University College London, London, United Kingdom
Am J Respir Cell Mol Biol 26:135-43. 2002....
- Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1Takashi Miki
Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
Nat Med 8:466-72. 2002..We report here that mice lacking the gene encoding Kir6.1 (known as Kcnj8) have a high rate of sudden death associated with spontaneous ST elevation followed by atrioventricular block as ..
- Diversity of Kir channel subunit mRNA expressed by retinal glial cells of the guinea-pigMaik Raap
Paul Flechsig Institute of Brain Research, Leipzig University, Jahnallee 59, D 04109 Leipzig, Germany
Neuroreport 13:1037-40. 2002....
- ATP-sensitive potassium channels mediate dilatation of basilar artery in response to intracellular acidification in vivoNaohiko Santa
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Stroke 34:1276-80. 2003..The objective of the present study was to examine the mechanisms by which intracellular acidosis produces dilatation of the basilar artery in vivo...
- Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channelsLaura J Sampson
Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom
Circ Res 95:1012-8. 2004....
- Iptakalim, opener of K(ATP), reverses the enhanced expression of genes encoding K(ATP) subunits in spontaneously hypertensive ratsMin Gao
Department of Cardiovascular Pharmacology, Institute of Pharmacology and Toxicology, Beijing, P R China
Life Sci 77:2743-51. 2005..Furthermore, changes in Kir6.2 mRNA levels suggest that Kir6.x, as well as SUR, is responsible for drug binding...
- Expression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heartAlison Morrissey
Department of Pediatrics, NYU School of Medicine, New York, New York 10016, USA
Pediatr Res 58:185-92. 2005..Our data suggest that the K(ATP) channel composition may change during maturation, which has important implications for K(ATP) channel function in the developing heart...
- Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytesSheng Nan Wu
Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
Life Sci 80:378-87. 2007..The present results suggest that these two types of K(ATP) channels may functionally be related to the activity of heart cells...
- Differential effects of etomidate and midazolam on vascular adenosine triphosphate-sensitive potassium channels: isometric tension and patch clamp studiesAkiyo Nakamura
Department of Anesthesiology, University of Tokushima Graduate School, Tokushima, Japan
Anesthesiology 106:515-22. 2007..The aim of this study was to investigate the effects of two imidazoline-derived intravenous anesthetics, etomidate and midazolam, on vascular adenosine triphosphate-sensitive potassium (KATP) channel activity...
- PKA-dependent activation of the vascular smooth muscle isoform of KATP channels by vasoactive intestinal polypeptide and its effect on relaxation of the mesenteric resistance arteryYang Yang
Department of Biology, Georgia State University, 24 Peachtree Center Avenue, Atlanta, Georgia 30302 4010, USA
Biochim Biophys Acta 1778:88-96. 2008..These results therefore indicate that the vascular isoform (Kir6.1/SUR2B) of KATP channels is a target of VIP. The channel activation relies on the PKA pathway and produces mesenteric arterial relaxation...
- Persistent beneficial effect of postconditioning against infarct size: role of mitochondrial K(ATP) channels during reperfusionJames Mykytenko
Carlyle Fraser Heart Center, Emory Crawford Long Hospital, Emory University, Atlanta, GA 30308 2225, USA
Basic Res Cardiol 103:472-84. 2008..Thirty dogs undergoing 60 min of ischemia and 24 h of reperfusion (R) were randomly divided into four groups:..
- Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epitheliumDongli Yang
Department of Ophthalmology and Visual Sciences, University of Michigan, W K Kellogg Eye Center, Ann Arbor, MI 48105 0714, USA
Exp Eye Res 87:176-83. 2008..Our results indicate that human RPE expresses at least five other Kir channel subtypes in addition to Kir7.1, suggesting that multiple members of the Kir channel family may function in this epithelium...
- Downregulation of Kir6.1/SUR2B channels in the obese rat aortaLi Hong Fan
Department of Cardiology, The First Affiliated Hospital of Xi an Jiaotong University School of Medicine, Xi an, Shaanxi, China
Nutrition 25:359-63. 2009..This study was designed to evaluate the contribution of adenosine triphosphate-dependent potassium channels to the increase in blood pressure observed in obese rats...
- Single channel studies of the ATP-regulated potassium channel in brain mitochondriaKatarzyna Choma
Department of Biophysics, Warsaw University of Life Sciences SGGW, 159 Nowoursynowska St, 02 776, Warsaw, Poland
J Bioenerg Biomembr 41:323-34. 2009..1 channel subunit in the inner membrane from rat brain mitochondria. Taken together, our results demonstrate for the first time the single channel activity and properties of an ATP-regulated potassium channel from rat brain mitochondria...
- Central venous hypoxemia is a determinant of human atrial ATP-sensitive potassium channel expression: evidence for a novel hypoxia-inducible factor 1alpha-Forkhead box class O signaling pathwayVéronique Raeis
Department of Neuroscience, University of Geneva, 1211 Geneve 4, Switzerland
Hypertension 55:1186-92. 2010..1 gene via activation of HIF-1alpha-FOXO1. Because increased SUR2A/B/Kir6.1 has known survival benefits, this pathway offers novel therapeutic targets for children with heart disease...
- The ATP-sensitive K(+)-channel (K(ATP)) controls early left-right patterning in Xenopus and chick embryosSherry Aw
Center for Regenerative and Developmental Biology, and Biology Department, Tufts University, Medford, MA 02155, USA
Dev Biol 346:39-53. 2010..We propose a model by which K(ATP) channels control LR patterning via regulation of tight junctions...
- Synthesis of benzofuran, benzothiophene, and benzothiazole-based thioamides and their evaluation as K(ATP) channel openersAndreas Fischer
Institute of Organic and Macromolecular Chemistry, University of Dusseldorf, Universiätsstr 1, Dusseldorf, Germany
ChemMedChem 5:1749-59. 2010..1. A one-carbon spacer between the heterocyclic skeleton and the thioamide moiety was observed to be crucial for affinity and selectivity. Two of the most potent and selective compounds were studied by crystal structure analyses...
- Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cordXue Feng Wu
Department of Neurobiology, Parker University Research Institute, Dallas, TX 75229, USA
Pain 152:2605-15. 2011..This study may provide a new strategy for treating neuropathic pain using K(ATP) channel openers in the clinic...
- KATP channels are up-regulated with increasing age in human myometriumQingyou Du
Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, United Kingdom
Mech Ageing Dev 134:98-102. 2013..Thus, this study suggests that KATP channels are up-regulated with increasing age in human myometrium. This may help explain, at least partially, increased rate of birth complications in women aged over 35 years...
- KATP channels and cardiovascular disease: suddenly a syndromeColin G Nichols
Center for the Investigation of Membrane Excitability Diseases and Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Circ Res 112:1059-72. 2013..1, KCNJ8, and Kir6...
- Evidences for an ATP-sensitive potassium channel (KATP) in muscle and fat body mitochondria of insectMalgorzata Slocinska
Department of Animal Physiology and Development, Adam Mickiewicz University, Poznan, Poland Electronic address
J Insect Physiol 59:1125-32. 2013....
- Acute exposure of methylglyoxal leads to activation of KATP channels expressed in HEK293 cellsYang Yang
Now in Center for Neuroscience and Regeneration Rehabilitation Research, Department of Neurology, Yale University School of Medicine and Veterans Affairs Connecticut Healthcare System, USA
Acta Pharmacol Sin 35:58-64. 2014..In the present study we investigated the effects of MGO on the activity of KATP channels...
- Vascular endothelial growth factor secretion from pituitary folliculostellate cells: role of KATP channelsJ Budzik
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
J Neuroendocrinol 26:111-20. 2014..These data suggest that K(ATP) channels are expressed by FS cells and play a significant role in the control of VEGF secretion, and also that activation of K(ATP) channels inhibits the secretion of VEGF at the level of transcription...
- Direct activation of β-cell KATP channels with a novel xanthine derivativeRene Raphemot
Departments of Anesthesiology R R, D R S, S B, J S D, Pharmacology R R, J S D, and Molecular Physiology and Biophysics P K D, D A J and Institutes of Chemical Biology J S D and Global Health J S D, Vanderbilt University Medical Center, Nashville, Tennessee Department of Medicine, University of Rochester Medical Center, Rochester, New York A P W and Department of Cell Biology and Physiology P C, C G N and Center for the Investigation of Membrane Excitability Disorders P C, C G N, Washington University School of Medicine in St Louis, St Louis, Missouri
Mol Pharmacol 85:858-65. 2014..VU0071063 represents a novel tool/compound for investigating β-cell physiology, KATP channel gating, and a new chemical scaffold for developing improved activators with medicinal chemistry. ..
- ATP-sensitive potassium channels alleviate postoperative pain through JNK-dependent MCP-1 expression in spinal cordXiang Zhu
Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P R China
Int J Mol Med 35:1257-65. 2015..The results suggested that KATP channel opener treatment is an effective therapy for postoperative pain in animals, through the activation of the JNK/MCP-1 pathway in astrocytes...
- Diazoxide Cardioprotection Is Independent of Adenosine Triphosphate-Sensitive Potassium Channel Kir6.1 Subunit in Response to StressMatthew C Henn
Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO
J Am Coll Surg 221:319-25. 2015..The Kir6.1 subunit can also contribute to K(ATP) channels in the heart, and we hypothesized that this subunit might play a role in myocyte volume regulation in response to stress...
- Altered expression of ATP-sensitive K(+) channels in Hirschsprung's diseaseChristian Tomuschat
National Children s Research Centre, Our Lady s Children s Hospital, Crumlin, Dublin, Ireland
J Pediatr Surg 51:948-52. 2016..1/6.2 and SUR1/2) is reported. We designed this study to determine if K(ATP) channels exist within the human colon and to investigate the expression of different subunits in Hirschsprung's disease...
- Allicin relaxes isolated mesenteric arteries through activation of PKA-KATP channel in ratShuzhen Li
a Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, PR China
J Recept Signal Transduct Res 37:17-24. 2017..But allicin had no effect on the expression of KATP subtypes Kir6.1 and SUR2B. These observations suggest that allicin exerts vasorelaxation effect through activation of PKA-KATP-signaling pathway...
- Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and CardioprotectionColin G Nichols
Department of Cell Biology and Physiology, Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA Electronic address
Card Electrophysiol Clin 8:323-35. 2016....
- Genetic architecture dissection by genome-wide association analysis reveals avian eggshell ultrastructure traitsZhongyi Duan
National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China
Sci Rep 6:28836. 2016..ABCC9, ITPR2, KCNJ8 and WNK1, which are involved in ion transport, were suggested to be the key genes regulating EST and ET...
- Nitric oxide and Kir6.1 potassium channel mediate isoquercitrin-induced endothelium-dependent and independent vasodilation in the mesenteric arterial bed of ratsArquimedes Gasparotto Junior
Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Universidade Federal da Grande Dourados, Rodovia dourados Itahum, km 12, P O Box 533, 79 804 970 Dourados, MS, Brazil Electronic address
Eur J Pharmacol 788:328-34. 2016..Our study shows that isoquercitrin induces vasodilation in resistance arteries, an effect mediated by K(+) channel opening and endothelial nitric oxide production. ..
- Activation of ATP-sensitive potassium channels facilitates the function of human endothelial colony-forming cells via Ca2+ /Akt/eNOS pathwayYan Wu
Department of Respiratory Medicine, Wuxi People s Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China
J Cell Mol Med . 2016..The present work highlighted a novel profile of KATP as a potential target for ECFC modulation, which may hold the key to the treatment of PVD...
- Increased tolerance to stress in cardiac expressed gain-of-function of adenosine triphosphate-sensitive potassium channel subunit Kir6.1Matthew C Henn
Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri
J Surg Res 206:460-465. 2016..1 subunits has been implicated in cardiac pathology in Cantu syndrome in humans (cardiomegaly, lymphedema, and pericardial effusions). We hypothesized that GOF of Kir6.1 subunits would result in altered myocyte response to stress...
- Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse chromosome 6S Isomoto
Department of Pharmacology II, Faculty of Medicine, Osaka University, Japan
Mamm Genome 8:790-1. 1997
- Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunitsK Lee
Parke Davis Neuroscience Research Centre, Cambridge University Forvie Site, Cambridge CB2 2QB, UK
J Physiol 515:439-52. 1999..2 or SUR2. 6. It is concluded that glucose-receptive neurones within the rat ventromedial hypothalamus exhibit a KATP channel current with pharmacological and molecular properties similar to those reported in other tissues...
- Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closureH Dorschner
Institut fur Pharmakologie und Toxikologie, Universität Braunschweig, Mendelssohnstrabetae 1, 38106 Braunschweig, Germany
Mol Pharmacol 55:1060-6. 1999..93-1.06). The data establish that the C terminus of SURs does not affect sulfonylurea affinity and sensitivity. We conclude that occupation of one of the four SUR sites per channel complex is sufficient to induce KATP channel closure...
- KATP channels gated by intracellular nucleotides and phospholipidsT Baukrowitz
Department of Physiology II, Tubingen, Germany
Eur J Biochem 267:5842-8. 2000..This review discusses the mechanisms and molecular determinants that underlie gating of KATP channel by nucleotides and phospholipids and their physiological implications...
- Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout miceM Suzuki
Department of Pharmacology, Chiba University School of Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
Circ Res 88:570-7. 2001..1 mRNA was expressed. These findings indicate that the Kir6.2 subunit mediates the depression of cardiac excitability and contractility induced by KCOs; in contrast, Kir6.2 plays no discernible role in the arterial tree...
- ATP-sensitive K(+) channels composed of Kir6.1 and SUR2B subunits in guinea pig gastric myocytesJae Hoon Sim
Department of Physiology and Biophysics, Seoul National University College of Medicine, Seoul 110 799, Korea
Am J Physiol Gastrointest Liver Physiol 282:G137-44. 2002..RT-PCR demonstrated the presence of Kir6.1, Kir6.2, and SUR2B in guinea pig stomach smooth muscle cells. These results suggest that K(ATP) channels in smooth muscle cells of the guinea pig stomach are composed of Kir6.1 and SUR2B...
- Physiological and pathophysiological roles of ATP-sensitive K+ channelsSusumu Seino
Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana Chuo ku, Chiba 260 8760, Japan
Prog Biophys Mol Biol 81:133-76. 2003..In this review, we focus on the physiological and pathophysiological roles of K(ATP) channels learned from genetic manipulation of mice and naturally occurring mutations in humans...
- Gene targeting approach to clarification of ion channel function: studies of Kir6.x null miceSusumu Seino
Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
J Physiol 554:295-300. 2004..Our studies of Kir6.2 null (knockout) and Kir6.1 null mice have shown that K(ATP) channels are critical metabolic sensors in protection against acute metabolic stress such as hyperglycaemia, hypoglycaemia, ischaemia and hypoxia...
- Altered mRNA expression of ATP-sensitive and inward rectifier potassium channel subunits in streptozotocin-induced diabetic rat heart and aortaYajun Ren
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medial College, Beijing, China
J Pharmacol Sci 93:478-83. 2003..1, Kir3.1, Kir6.1, and Kir6.2 in diabetic rats. These results suggested that expression of specific K(ATP) channel subunits were altered in the heart and aorta of diabetic rats...
- Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channelsTakashi Kawano
Department of Anesthesiology, Tokushima University School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
Anesthesiology 100:338-46. 2004..1 or Kir6.2) genes and sulfonylurea receptor (SUR1, SUR2A, or SUR2B) genes...
- Warm blood cardioplegic arrest induces mitochondrial-mediated cardiomyocyte apoptosis associated with increased urocortin expression in viable cellsTiziano M Scarabelli
Division of Cardiology, St John Hospital and Medical Center, Wayne State University, Detroit, Mich, USA
J Thorac Cardiovasc Surg 128:364-71. 2004..Here we extend these findings to the human heart exposed to ischemic-reperfusion injury...
- Pore-forming subunits of K-ATP channels, Kir6.1 and Kir6.2, display prominent differences in regional and cellular distribution in the rat brainAchim Thomzig
Centrum für Anatomie, Charite, Universitatsmedizin Berlin, D 10115 Berlin, Germany
J Comp Neurol 484:313-30. 2005..Only in distinct nuclei or neuronal subpopulations is a moderate or even strong Kir6.1 staining detected. The biological functions of these K-ATP channels still need to be elucidated...
- Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease?Sen Wang
Department of Pharmacology and Neurobiology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China
Neuropharmacology 48:984-92. 2005..Our results suggest that KATP channels might be involved in the pathogenesis of Parkinson's disease (PD) induced in an animal model and conceptually support the idea that KATP channels may be new therapeutic targets for PD...
- ATP-sensitive K+-channel subunits on the mitochondria and endoplasmic reticulum of rat cardiomyocytesMing Zhou
Department of Anatomy, Akita University School of Medicine, Japan
J Histochem Cytochem 53:1491-500. 2005..The data obtained in this study will be useful for analyzing the composition of K(ATP) channels of cardiomyocytes and help to understanding the cardioprotective role of K(ATP) channels during heart ischemia...
- Subunit composition of ATP-sensitive potassium channels in mitochondria of rat heartsDang Van Cuong
Department of Physiology and Biophysics, Mitochondrial Signaling Laboratory, College of Medicine, Biohealth Products Research Center, Inje University, 633 165 Gaegeum dong, Busanjin Ku, Busan 614 735, South Korea
Mitochondrion 5:121-33. 2005..By contrast, SUR1 was not present in mitochondria. These results suggest that mitoKATP channels in rat hearts might comprise a combination of Kir6.1, Kir6.2, and SUR2 subunits...
- Diabetes and hypoglycaemia in young children and mutations in the Kir6.2 subunit of the potassium channel: therapeutic consequencesI Flechtner
Clinique des Maladies du Développement, Unité d endocrinologie, Diabétologie et Gynécologie Pédiatrique, Hopital Necker Enfants Malades, 149, rue de Sevres, Paris, France
Diabetes Metab 32:569-80. 2006..This is a spectacular example by which a pharmacogenomic approach improves the quality of life of our young diabetic patients in a tremendous way...
- ATP-sensitive potassium currents reduce the PGE2-mediated enhancement of excitability in adult rat sensory neuronsXian Xuan Chi
Department of Pharmacology and Toxicology, 635 Barnhill Drive, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Brain Res 1145:28-40. 2007..These results demonstrate that activation of K(ATP) can reverse the sensitization produced by PGE(2) and may be an important means to modulate the enhanced excitability that results from inflammatory or injury conditions...
- Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted ratsDomenico Tricarico
Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, via Orabona no 4, 70120 Bari, Italy
Neuromuscul Disord 18:74-80. 2008..Kir6.2/SUR2A deficiency is associated with impaired muscle function in K(+)-depleted rats and in hypoPP...
- epsilonPKC phosphorylates the mitochondrial K(+) (ATP) channel during induction of ischemic preconditioning in the rat hippocampusAmi P Raval
Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience Program, University of Miami Leonard M Miller School of Medicine, Miami, FL 33101, USA
Brain Res 1184:345-53. 2007..2 as a phosphorylation target of epsilonPKC or its downstream effectors. Our results support the hypothesis that the brain mtK(+)(ATP) channel is an important target of IPC and the signal transduction pathways initiated by epsilonPKC...
- Forkhead transcription factors coordinate expression of myocardial KATP channel subunits and energy metabolismPierre Philip-Couderc
Department of Neuroscience, Hopitaux Universitaires de Geneve, Centre Medical Universitaire, Geneva, Switzerland
Circ Res 102:e20-35. 2008..Thus, FoxF2 and -O are key transcription factors coordinating expression of KATP channels and energy metabolism...
- Patents related to therapeutic activation of K(ATP) and K(2P) potassium channels for neuroprotection: ischemic/hypoxic/anoxic injury and general anestheticsSusan I V Judge
University of Maryland School of Medicine, MS Center of Excellence East, VA Maryland Health Care System, Department of Neurology, BRB 12 040, 655 West Baltimore Street, Baltimore, MD 21201, USA
Expert Opin Ther Pat 19:433-60. 2009..1 (kcnj8) or k(ir)6...
- The intracellular localization and function of the ATP-sensitive K+ channel subunit Kir6.1Keat Eng Ng
Deparment of Medicine, The Rayne Institute, University College London, Room 107, University Street, London, WC1E 6JF, UK
J Membr Biol 234:137-47. 2010..This study suggests that Kir6.1 is located in the endoplasmic reticulum and plays a role in modifying Ca2+ release from intracellular stores...
- Targeting hypertension with a new adenosine triphosphate-sensitive potassium channel opener iptakalimZhiYuan Pan
Department of Cardiovascular Pharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China
J Cardiovasc Pharmacol 56:215-28. 2010..In additional to strong antihypertensive efficacy, iptakalim seems to have a favorable safety and tolerability profile. Iptakalim is a promising new generation antihypertensive drug...
- Muscle KATP channels: recent insights to energy sensing and myoprotectionThomas P Flagg
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Physiol Rev 90:799-829. 2010..As yet, few human diseases have been correlated with altered muscle K(ATP) activity, but genetically modified animals give important insights to likely pathological roles of aberrant channel activity in different muscle types...
- The effects of potassium channel opener P1075 on the human saphenous vein and human internal mammary arteryLjiljana C Gojkovic-Bukarica
Department of Clinical Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, University Belgrade, Belgrade, Serbia
J Cardiovasc Pharmacol 57:648-55. 2011..This effect is graft and vasoconstrictor selective and seems to be mediated by Kir6.1- and/or Kir6.2-containing KATP channels. Thus, P1075 can be considered as a potential drug in the prevention of graft spasm...
- Expression of ATP-sensitive potassium channels in human pregnant myometriumChen Xu
Department of Physiology, Second Military Medical University, Shanghai 200433, China
Reprod Biol Endocrinol 9:35. 2011..The objectives of this study were to investigate the protein expression of KATP channel in human myometrium and determine the levels of KATP channel in lower and upper segmental myometrium before and after onset of labour...
- K(ATP) channel action in vascular tone regulation: from genetics to diseasesWei Wei Shi
Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory University, Atlanta, GA 30308, USA
Sheng Li Xue Bao 64:1-13. 2012....
- Comparative proteomic analysis of the ATP-sensitive K+ channel complex in different tissue typesEirini Kefaloyianni
Pediatrics, NYU School of Medicine, New York, NY 10016, USA
Proteomics 13:368-78. 2013..Overall, our data demonstrate that K(ATP) channels in different tissues may assemble with proteins having common functions, but that tissue-specific complex organization also occurs...
- Cardiac K(ATP) channel alterations associated with acclimation to hypoxia in goldfish (Carassius auratus L.)John S Cameron
Department of Biological Sciences, Wellesley College, Wellesley, MA 02481, USA
Comp Biochem Physiol A Mol Integr Physiol 164:554-64. 2013..1 and Kir6.2), mRNA transcription of kcnj8 (revealed by quantitative real-time PCR) was unchanged while kcnj11 was downregulated in response to chronic low ..
- Transgenic Expression of Kir6.1 Gain-of-Function Mutations in the Mouse Heart Result in Increased L-Type Calcium Current in Ventricular MyocytesM D Levin
Washington University School of Medicine, Saint Louis, MO
Heart Rhythm 10:1741. 2013..Surprisingly, L-type calcium channel current (LTCCC) was increased in Kir6.2 GOF ventricular myocytes (VM), suggesting that increased IKATP secondarily leads to increased LTCCC...
- The SUR2B subunit of rat vascular KATP channel is targeted by miR-9a-3p induced by prolonged exposure to methylglyoxalShan shan Li
Department of Biology, Georgia State University, Atlanta, Georgia
Am J Physiol Cell Physiol 308:C139-45. 2015..These results suggest that MGO exposure raises the expression of miR-9a-3p, which subsequently downregulates the SUR2B mRNA, compromising K(ATP) channel function in vascular smooth muscle...
- Potassium Channels as Macromolecular ComplexesThomas A Neubert; Fiscal Year: 2013..Our findings may have important implications for understanding the role of KATP channels in the heart and coronary vasculature under physiological and non-pathophysiological conditions. ..
- Colin G Nichols; Fiscal Year: 2016..abstract_text> ..
- Conditional knockout mice lacking K(ATP) channel subunitsWilliam A Coetzee; Fiscal Year: 2010....
- BRUCE A BEUTLER; Fiscal Year: 2016..Among these are channel proteins (SLC15A4;KCNJ8/SUR2), transcription factors (IKB;AKIRIN2), proteins concerned with membrane trafficking or organellar mobility (..
- Sulfonylurea KATP channels in vascular spasmElizabeth McNally; Fiscal Year: 2009..We will also study the role of cardiac and vascular smooth muscle KATP channels in mediating the response to acute adrenergically mediated stress. ..
- Role of Kir6.1 subunits of K+ channels in heartWILLIAM COETZEE; Fiscal Year: 2004..1 subunits, and will provide molecular insights into the function of KATP channels in animals during normal and pathophysiological conditions. ..
- SUR Transmembrane Domain in K(ATP) Channel FunctionRobert Harvey; Fiscal Year: 2006..These results underscore the importance of the TMDO of SUR as an important structural element involved in the interactions with K1r6. My application aims to elucidate the role of the TMDO in the function of the KATP channel. ..
- ATP-Sensitive K Channels in Renal Proximal TubuleAlan Segal; Fiscal Year: 2007..unreadable] [unreadable]..
- Metabolism-excitation coupling in the heartColin Nichols; Fiscal Year: 2005..The work will provide information that will ultimately underlie the development of rational therapies for the treatment of cardiac ischemia and arrhythmias. ..
- Effect of Daily Exercise on Cardiac Autonomic RegulationGEORGE BILLMAN; Fiscal Year: 2005..Ventricular contractile responses to Beta1- and Beta2-adrenoceptor stimulation will be examined in vivo by echocardiography and in vitro by single cell fluorescence microscopy/video edge detection. ..
- Identification of Disease Genes for Atrial FibrillationTimothy Olson; Fiscal Year: 2009..The long-term objectives of this work are to gain new insights into molecular mechanisms of arrhythmogenesis and to improve prediction, prevention, and treatment of AF. ..
- Dietary Omega-3 Fatty Acids and Sudden Cardiac DeathGEORGE EDWARD BILLMAN; Fiscal Year: 2010..This project will also determine the effectiveness of fish oil supplements in reducing sudden death due to a lethal abnormal heart rhythm after a heart attack. ..