KCNMA1

Summary

Gene Symbol: KCNMA1
Description: potassium calcium-activated channel subfamily M alpha 1
Alias: BKTM, KCa1.1, MaxiK, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, hSlo, mSLO1, calcium-activated potassium channel subunit alpha-1, uncharacterized protein, BK channel alpha subunit, BKCA alpha subunit, big potassium channel alpha subunit, calcium-activated potassium channel, subfamily M subunit alpha-1, k(VCA)alpha, maxi-K channel HSLO, potassium channel, calcium activated large conductance subfamily M alpha, member 1, potassium large conductance calcium-activated channel, subfamily M, alpha member 1, slo homolog, slowpoke homolog, stretch-activated Kca channel
Species: human

Top Publications

  1. ncbi Properties of potassium currents and their role in membrane excitability in Drosophila larval muscle fibers
    S Singh
    Department of Biology, University of Iowa, Iowa City 52242
    J Exp Biol 152:59-76. 1990
  2. ncbi [Mechanism of pore formation on erythrocyte membrane by streptolysin-O]
    K Sekiya
    Laboratory of Microbiology, School of Pharmaceutical Sciences, Kitasato University
    Kansenshogaku Zasshi 67:736-40. 1993
  3. ncbi Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
    L Diaz
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
    J Biol Chem 273:32430-6. 1998
  4. ncbi Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits
    W J Joiner
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Neurosci 1:462-9. 1998
  5. ncbi Scanning laser densitometry and color perimetry demonstrate reduced photopigment density and sensitivity in two patients with retinal degeneration
    R P Tornow
    Department of Pathophysiology of Vision and Neuro ophthalmology, University Eye Hospital, Tubingen, Germany
    Vision Res 39:3630-41. 1999
  6. pmc HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation
    Q H Liu
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 97:4832-7. 2000
  7. ncbi mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels
    A Butler
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110
    Science 261:221-4. 1993
  8. ncbi Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle
    H G Knaus
    Department of Membrane Biochemistry and Biophysics, Merck Research Laboratories, Rahway, New Jersey 07065
    J Biol Chem 269:17274-8. 1994
  9. ncbi A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels
    P Meera
    Dept of Anesthesiology, University of California, Los Angeles 90095 1778, USA
    FEBS Lett 382:84-8. 1996
  10. ncbi Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium
    M Wallner
    Department of Anesthesiology, UCLA, 90095, USA
    Receptors Channels 3:185-99. 1995

Research Grants

  1. Near Infrared Detector for Advanced Ophthalmology
    Richard Myers; Fiscal Year: 2013
  2. Anne B Fulton; Fiscal Year: 2015
  3. High Performance Multimodal Adaptive Optics Retinal Imaging
    R Daniel Ferguson; Fiscal Year: 2011
  4. Multimode Adaptive Optics Retinal Imager for Diagnosis of Age-Related Macular Deg
    Daniel Hammer; Fiscal Year: 2009
  5. Dennis L Stevens; Fiscal Year: 2016
  6. Philip J Santangelo; Fiscal Year: 2014
  7. Riccardo Olcese; Fiscal Year: 2014
  8. Michael G Caparon; Fiscal Year: 2014
  9. Rodney K Tweten; Fiscal Year: 2015
  10. Alexey V Zaitsev; Fiscal Year: 2015

Detail Information

Publications221 found, 100 shown here

  1. ncbi Properties of potassium currents and their role in membrane excitability in Drosophila larval muscle fibers
    S Singh
    Department of Biology, University of Iowa, Iowa City 52242
    J Exp Biol 152:59-76. 1990
    ..The Shaker (Sh) and the slowpoke (slo) mutations, respectively, eliminate the voltage-activated fast K+ current (IA) and the Ca2(+)-activated fast K+ ..
  2. ncbi [Mechanism of pore formation on erythrocyte membrane by streptolysin-O]
    K Sekiya
    Laboratory of Microbiology, School of Pharmaceutical Sciences, Kitasato University
    Kansenshogaku Zasshi 67:736-40. 1993
    The erythrocyte membrane damaged by streptolysin-O (SLO) was observed in negative staining electron microscopy...
  3. ncbi Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
    L Diaz
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
    J Biol Chem 273:32430-6. 1998
    We investigated the role of individual charged residues of the S4 region of a MaxiK channel (hSlo) in channel gating...
  4. ncbi Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits
    W J Joiner
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Neurosci 1:462-9. 1998
    ..Only one gene Slo is known to encode maxi-K channels, which are sensitive to both membrane potential and intracellular calcium...
  5. ncbi Scanning laser densitometry and color perimetry demonstrate reduced photopigment density and sensitivity in two patients with retinal degeneration
    R P Tornow
    Department of Pathophysiology of Vision and Neuro ophthalmology, University Eye Hospital, Tubingen, Germany
    Vision Res 39:3630-41. 1999
    To test the feasibility of scanning laser densitometry with a modified Rodenstock scanning laser ophthalmoscope (SLO) to measure the rod and cone photopigment distribution in patients with retinal diseases.
  6. pmc HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation
    Q H Liu
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 97:4832-7. 2000
    ..Intracellular signaling responses of macrophages to HIV-1 may modulate postentry steps of infection and cell functions apart from infection...
  7. ncbi mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels
    A Butler
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110
    Science 261:221-4. 1993
    ..A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene...
  8. ncbi Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle
    H G Knaus
    Department of Membrane Biochemistry and Biophysics, Merck Research Laboratories, Rahway, New Jersey 07065
    J Biol Chem 269:17274-8. 1994
    ..Furthermore, we demonstrate that the cloned protein is the subunit to which charybdotoxin is specifically and covalently incorporated when cross-linked to the channel...
  9. ncbi A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels
    P Meera
    Dept of Anesthesiology, University of California, Los Angeles 90095 1778, USA
    FEBS Lett 382:84-8. 1996
    KV,Ca beta subunit dramatically increases the apparent calcium sensitivity of the alpha subunit of MaxiK channels when probed in the micromolar [Ca2+]i range...
  10. ncbi Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium
    M Wallner
    Department of Anesthesiology, UCLA, 90095, USA
    Receptors Channels 3:185-99. 1995
    cDNAs encoding functional maxi KCa channel alpha-subunits (hslo) were cloned from human myometrium. Northern blot analysis revealed a high abundance of mRNA in human uterine smooth muscle...
  11. pmc Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus
    M Wallner
    Department of Anesthesiology, University of California Los Angeles 90095 1778, USA
    Proc Natl Acad Sci U S A 93:14922-7. 1996
    The pore-forming alpha subunit of large conductance voltage- and Ca(2+)-sensitive K (MaxiK) channels is regulated by a beta subunit that has two membrane-spanning regions separated by an extracellular loop...
  12. pmc Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus
    P Meera
    Department of Anesthesiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 94:14066-71. 1997
    Large conductance voltage- and Ca2+-dependent K+ (MaxiK) channels show sequence similarities to voltage-gated ion channels. They have a homologous S1-S6 region, but are unique at the N and C termini...
  13. pmc Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog
    M Wallner
    Department of Anesthesiology, University of California, Los Angeles, CA 90095 1778, USA
    Proc Natl Acad Sci U S A 96:4137-42. 1999
    Voltage-dependent and calcium-sensitive K+ (MaxiK) channels are key regulators of neuronal excitability, secretion, and vascular tone because of their ability to sense transmembrane voltage and intracellular Ca2+...
  14. ncbi Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit
    M A Valverde
    Departament de Ciencies Experimentals i de la Salut, Universidad Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Science 285:1929-31. 1999
    ..Estradiol bound to the beta subunit and activated the Maxi-K channel (hSlo) only when both alpha and beta subunits were present...
  15. ncbi Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4
    R Brenner
    Howard Hughes Medical Institute, Molecular and Cellular Physiology, Stanford School of Medicine, Stanford, California 94305, USA
    J Biol Chem 275:6453-61. 2000
    ..Although we found that hKCNMB3 does interact with Hslo channels, its effects on Hslo1 channel properties were slight, increasing Hslo1 activation rates...
  16. ncbi Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels
    Ying wei Wang
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 22:1550-61. 2002
    ..Thus, the stoichiometry of alpha:beta subunit assembly can play a major functional role in defining the apparent Ca2+ dependence of activation of BK channels and in influencing the availability of BK channels for activation...
  17. pmc Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+
    Xiaowei Niu
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33101 6430, USA
    Proc Natl Acad Sci U S A 99:11441-6. 2002
    BK channels (Slo1) are widely distributed K+ channels that control Ca2+-dependent processes and cellular excitability. Their activation by intracellular Ca2+ (Ca(i)2+) is highly cooperative, with Hill coefficients of typically 2-5...
  18. pmc Gating mechanism of BK (Slo1) channels: so near, yet so far
    Karl L Magleby
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33101, USA
    J Gen Physiol 121:81-96. 2003
  19. ncbi Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels
    Xiang Dong Tang
    Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 425:531-5. 2003
    ..A class of ion channel, the large-conductance calcium-dependent Slo1 BK channels, possesses a conserved haem-binding sequence motif...
  20. ncbi Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels
    Chien Chang Chen
    Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    Science 302:1416-8. 2003
    ..Furthermore, acute blockade of T-channels with Ni2+ prevented relaxation of wild-type coronary arteries. Thus, Ca2+ influx through alpha1H T-type Ca2+ channels is essential for normal relaxation of coronary arteries...
  21. pmc Distinct stoichiometry of BKCa channel tetramer phosphorylation specifies channel activation and inhibition by cAMP-dependent protein kinase
    Lijun Tian
    Membrane Biology Group, Division of Biomedical Science, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    Proc Natl Acad Sci U S A 101:11897-902. 2004
    ..This essentially digital regulation has important implications for the combinatorial and conditional regulation of BK(Ca) channels by reversible protein phosphorylation...
  22. ncbi Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current
    Adam M Brainard
    Department of Physiology and Biophysics, Carver College of Medicine, University of Iowa, 5 660 Bowen Science Bldg, Iowa City, Iowa 52242, USA
    Am J Physiol Cell Physiol 289:C49-57. 2005
    ..These data indicate that the actin cytoskeleton is involved as part of a caveolar complex in the regulation of myometrial maxi-K channel function...
  23. pmc Distinct structural features of phospholipids differentially determine ethanol sensitivity and basal function of BK channels
    John J Crowley
    Program in Neuroscience, Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Mol Pharmacol 68:4-10. 2005
    ..We addressed these questions by reconstituting BK channels from human brain (hslo) into bilayers that contained phospholipids differing in headgroup size, charge, and acyl chain saturation...
  24. ncbi Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder
    Wei Du
    Center for Molecular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44115, USA
    Nat Genet 37:733-8. 2005
    ....
  25. ncbi Functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (BK) alpha-subunits generated from a single site of splicing
    Lie Chen
    Centre for Integrative Physiology, Membrane Biology Group, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, United Kingdom
    J Biol Chem 280:33599-609. 2005
    ....
  26. pmc Homology modeling identifies C-terminal residues that contribute to the Ca2+ sensitivity of a BKCa channel
    Jian zhong Sheng
    Department of Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Biophys J 89:3079-92. 2005
    ..These findings, along with other recent data, are considered in the context of the calcium bowl's high affinity Ca(2+) sensor and the known properties of EF hands...
  27. ncbi International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels
    Aguan D Wei
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Pharmacol Rev 57:463-72. 2005
  28. pmc Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry
    Nicoletta Savalli
    Departments of Anesthesiology Division of Molecular Medicine, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, CA 90095 7115, USA
    Proc Natl Acad Sci U S A 103:12619-24. 2006
    ..Extremely slow conformational changes were revealed by fluorescent labeling of position 202, elicited by a mutual interaction of the fluorophore with the adjacent tryptophan 203...
  29. ncbi KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer
    M Bloch
    Institute for Pathology, University Hospital Basel, Basel, Switzerland
    Oncogene 26:2525-34. 2007
    ..Here, we studied gene amplification of the large conductance calcium-activated potassium channel alpha subunit (KCNMA1), which is located at the chromosomal region 10q22...
  30. pmc Diabetes-induced changes in the alternative splicing of the slo gene in corporal tissue
    Kelvin P Davies
    Department of Urology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Eur Urol 52:1229-37. 2007
    Erectile dysfunction is a common diabetic complication. Preclinical studies have documented that the Slo gene (encoding the BK or Maxi-K channel alpha-subunit) plays a critical role in erectile function...
  31. ncbi Gating and conductance changes in BK(Ca) channels in bilayers are reciprocal
    Robert J O'Connell
    Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 303 Belmont Street, Worcester, Massachusetts, 01604, USA
    J Membr Biol 213:143-53. 2006
    ..We examined the single-channel conductance (G(c)) and gating (open probability, P (o)) of single BK(Ca) channels (hslo alpha-subunits) inserted into planar lipid bilayers containing 1,2-dioleoyl-3-phosphatidylethanolamine (DOPE) or ..
  32. pmc Modes of operation of the BKCa channel beta2 subunit
    Nicoletta Savalli
    Department of Anesthesiology Division of Molecular Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
    J Gen Physiol 130:117-31. 2007
    ..Applying voltage clamp fluorometry to fluorescently labeled human BK(Ca) channels (hSlo), we have investigated the mechanisms of operation of the beta(2) subunit...
  33. pmc Acute alcohol tolerance is intrinsic to the BKCa protein, but is modulated by the lipid environment
    Chunbo Yuan
    Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
    J Biol Chem 283:5090-8. 2008
    ..As a consequence of these findings the protein-lipid complex should be treated as a unit when studying ethanol action...
  34. pmc The RCK2 domain of the human BKCa channel is a calcium sensor
    Taleh Yusifov
    Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7115, USA
    Proc Natl Acad Sci U S A 105:376-81. 2008
    ..We speculate that the molecular rearrangements of RCK2 likely underlie the Ca(2+)-dependent gating mechanism of BK(Ca) channels. A structural model of the heterodimeric complex of hSloRCK1 and hSloRCK2 domains is discussed...
  35. pmc Intrinsic electrostatic potential in the BK channel pore: role in determining single channel conductance and block
    Ingrid Carvacho
    Centro de Estudios Cientificos, Casilla, Valdivia, Chile
    J Gen Physiol 131:147-61. 2008
    ..contains a ring of eight negative charges not present in K(+) channels of lower conductance (Glu386 and Glu389 in hSlo) that modulates channel conductance through an electrostatic mechanism (Brelidze, T.I., X. Niu, and K.L. Magleby...
  36. pmc The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels
    Shangwei Hou
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:4039-43. 2008
    ..Among them, large-conductance Ca(2+)- and voltage-gated K(+) (Slo1 BK) channels, important in vasodilation and neuronal firing, have been suggested to be directly stimulated by CO...
  37. pmc Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain
    Shangwei Hou
    Department of Physiology, University of Pennsylvania, 3700 Hamilton Walk, Philadelphia, Pennsylvania 19104, USA
    Nat Struct Mol Biol 15:403-10. 2008
    ..evidence suggests that intracellular H+ directly stimulates large-conductance Ca2+- and voltage-activated K+ (SLO1 BK) channels, thus providing a crucial link between membrane excitability and cell metabolism...
  38. doi Insulin increases the activity of mesangial BK channels through MAPK signaling
    Ruth M Foutz
    Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Renal Physiol 294:F1465-72. 2008
    ..These results indicate that insulin activates BK in the plasma membrane of MC and stimulates, via MAPK, an increase in cellular and plasma membrane BK-alpha...
  39. doi Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial infarction
    Marta Tomas
    Unitat de Lipids i Epidemiologia Cardiovascular, Grup d Epidemiologia i Genètica Cardiovasculars, Program of Research in Inflammatory and Cardiovascular Disorders, Institut Municipal d Investigacio Medica, Barcelona, Spain
    J Hypertens 26:2147-53. 2008
    ..Previous studies have shown that a polymorphism in the beta1 regulatory subunit of the Ca2+ -dependent potassium channel modulates the risk of diastolic hypertension in humans...
  40. pmc Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes
    Eun Young Kim
    Department of Biology and Biochemistry, University of Houston, Houston, TX 77204 5001, USA
    Mol Pharmacol 75:466-77. 2009
    Large-conductance (BK(Ca) type) Ca(2+)-activated K(+) channels encoded by the Slo1 gene and various canonical transient receptor potential channels (TRPCs) are coexpressed in many cell types, including podocytes (visceral epithelial cells)..
  41. pmc Role of KCNMA1 gene in breast cancer invasion and metastasis to brain
    Divya Khaitan
    Department of Laboratory Oncology Research, Curtis and Elizabeth Anderson Cancer Institute, Hoskins Center for Biomedical Research, Savannah, Georgia 31404, USA
    BMC Cancer 9:258. 2009
    ..In this study we investigated the role of KCNMA1 gene that encodes for the pore-forming alpha-subunit of BKCa channels in breast cancer metastasis and invasion.
  42. pmc Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy
    Liguo Wang
    Department of Cellular and Molecular Physiology, Yale University, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Nature 461:292-5. 2009
    ..7-2.0 nm. Not requiring the formation of crystals, the RSC approach promises to be useful in the structural study of many other membrane proteins as well...
  43. pmc Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain
    Shangwei Hou
    Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 285:6434-42. 2010
    ..here that intracellular Zn(2+) potently and reversibly activates large-conductance voltage- and Ca(2+)-activated Slo1 K(+) (BK) channels...
  44. pmc Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution
    Peng Yuan
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10065, USA
    Science 329:182-6. 2010
    ..The structure suggests that the Ca2+ gating ring, in addition to regulating the pore directly, may also modulate the voltage sensor...
  45. pmc Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel
    Yunkun Wu
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    Nature 466:393-7. 2010
    ....
  46. doi LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium
    Jiusheng Yan
    Section of Neurobiology, Center for Learning and Memory, University of Texas, Austin, Texas 78712, USA
    Nature 466:513-6. 2010
    ....
  47. pmc The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements
    Taleh Yusifov
    Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    J Gen Physiol 136:189-202. 2010
    ..We provide evidence that the RCK1 domain is a high-affinity Ca(2+) sensor that transduces Ca(2+) binding into structural rearrangements, likely representing elementary steps in the Ca(2+)-dependent activation of human BK(Ca) channels...
  48. doi Function of BKCa channels is reduced in human vascular smooth muscle cells from Han Chinese patients with hypertension
    Yan Yang
    Key Laboratory of Medical Electrophysiology, Ministry of Education of China, and the Institute of Cardiovascular Research, Luzhou Medical College, Luzhou, Sichuan, China
    Hypertension 61:519-25. 2013
    ..This may account, at least in part, for the dysfunction of artery relaxation in Han Chinese patients with primary hypertension...
  49. ncbi Cloning and characterization of glioma BK, a novel BK channel isoform highly expressed in human glioma cells
    Xiaojin Liu
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 22:1840-9. 2002
    ..we report the isolation, cloning, and functional characterization of glioma BK (gBK), a novel splice isoform of hSlo, the gene that encodes the alpha-subunits of human BK channels...
  50. doi Silencing of hSlo potassium channels in human osteosarcoma cells promotes tumorigenesis
    Beatrice Cambien
    Universite de Nice Sophia Antipolis, UFR Sciences, Nice F 06002, France
    Int J Cancer 123:365-71. 2008
    ..Here, using stable RNA interference to reduce the expression of hSlo, the human pore-forming alpha-subunit of the BK channel, in human Cal72 OS cells, we show that BK channels play a ..
  51. ncbi Endocytic trafficking signals in KCNMB2 regulate surface expression of a large conductance voltage and Ca(2+)-activated K+ channel
    M M Zarei
    Department of Anesthesiology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neuroscience 147:80-9. 2007
    ..with the human pore-forming alpha subunit of the large conductance voltage and Ca(2+)-activated K(+) channel (hSlo) yields inactivating currents similar to those observed in hippocampal neurons [Hicks GA, Marrion NV (1998) Ca(2+)-..
  52. pmc Hypotension induced by activation of the transient receptor potential vanilloid 4 channels: role of Ca2+-activated K+ channels and sensory nerves
    Feng Gao
    Division of Nanomedicine and Molecular Intervention, Department of Medicine, Michigan State University, East Lansing, Michigan, USA
    J Hypertens 28:102-10. 2010
    ..To examine the mechanisms involved in hypotension induced by transient receptor potential vanilloid 4 (TRPV4) activation...
  53. ncbi The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans
    Marcus Guest
    School of Biological Sciences, Bassett Crescent East, University of Southampton, Southampton SO16 7PX, UK
    Int J Parasitol 37:1577-88. 2007
    ..To define the molecular basis for this we performed a mutagenesis screen. We recovered nine alleles of slo-1, which encodes a Ca(2+)-activated K(+) channel...
  54. doi Large-conductance calcium-activated potassium channels in purkinje cell plasma membranes are clustered at sites of hypolemmal microdomains
    Walter A Kaufmann
    Department of Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Comp Neurol 515:215-30. 2009
    ..1, or Slo1) in the somatodendritic compartment of cerebellar Purkinje cells by means of postembedding immunogold cytochemistry ..
  55. ncbi Effects of interferon-gamma and streptolysin O on hepatic procainamide N-acetyltransferase and various microsomal cytochrome P450-dependent monooxygenases in rats
    R Walter
    Department of Pharmacology, Medical Faculty of the Ernst-Moritz-Arndt University, Greifswald, Germany
    Immunopharmacol Immunotoxicol 18:571-86. 1996
    ..the effects of immunstimulating doses of rat interferon-gamma (IFN gamma, 670,000 units ip) and streptolysin O (SLO, 100 HU/kg iv for 5 days) on hepatic cytosolic N-acetyltransferase (NAT) and microsomal cytochrome P450 (CYP)-..
  56. ncbi Syntaxin-1A binds to and modulates the Slo calcium-activated potassium channel via an interaction that excludes syntaxin binding to calcium channels
    Susan M Cibulsky
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania
    J Neurophysiol 93:1393-405. 2005
    From its position in presynaptic nerve terminals, the large conductance Ca(2+)-activated K+ channel, Slo, regulates neurotransmitter release...
  57. ncbi [Properties of a hemolysin produced by group B streptococci]
    J Suzuki
    Department of Bioorganic Chemistry, College of Environmental Health Azabu University, Japan
    Kansenshogaku Zasshi 70:278-82. 1996
    ..The hemolytic activities of GBH were compared to that of streptolysin O (SLO) and streptolysin S (SLS). These hemolysins differed with respect to the binding and release of hemoglobin (Hb)...
  58. doi Social stress alters expression of large conductance calcium-activated potassium channel subunits in mouse adrenal medulla and pituitary glands
    O Chatterjee
    Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    J Neuroendocrinol 21:167-76. 2009
    ..Stress- and sex-steroids regulate alternative splicing of Slo-alpha, the pore-forming subunit of BK channels, and chronic behavioural stress has been shown to alter Slo splicing ..
  59. pmc Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels
    W R Sones
    Division of Basic Medical Sciences, St George s, University of London, London, UK
    Br J Pharmacol 158:521-31. 2009
    ..1 inhibited calcium-activated Cl(-) currents (I(ClCa)) and if the pharmacological overlap between K(Ca)1.1 and CaCCs extends to intermediate and small conductance, calcium-activated K(+) channels...
  60. ncbi Localization and developmental expression of BK channels in mammalian cochlear hair cells
    A Hafidi
    Laboratoire de Biologie Cellulaire et Moleculaire de l Audition, EA 3665, Universite de Bordeaux 2, Laboratoire de Biologie Cellulaire et Moleculaire de l Audition, CHU Hôpital Pellegrin, 33076 Bordeaux, France
    Neuroscience 130:475-84. 2005
    The expression of Slo channels (alpha subunits of BK channels) was investigated in the developing mouse cochlea using a polyclonal antibody against the C-terminal part of the protein (residues 1098-1196)...
  61. ncbi Ethanol interactions with calcium-dependent potassium channels
    Mark S Brodie
    Department of Physiology and Biophysics, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA
    Alcohol Clin Exp Res 31:1625-32. 2007
    ..neurons and other excitable cells, calcium-activated potassium channels of small (SK) and large conductance (BK; MaxiK) control excitability and neurotransmitter release...
  62. ncbi The beta 1 subunit of L-type voltage-gated Ca2+ channels independently binds to and inhibits the gating of large-conductance Ca2+-activated K+ channels
    Shengwei Zou
    Department of Biology and Biochemistry, University of Houston, 4800 Calhoun, Houston, TX 77204 5001
    Mol Pharmacol 73:369-78. 2008
    Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels encoded by the Slo1 gene are ubiquitously expressed, and they play a role in regulation of many cell types...
  63. pmc Ca2+- and thromboxane-dependent distribution of MaxiK channels in cultured astrocytes: from microtubules to the plasma membrane
    J W Ou
    Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, California, USA
    Glia 57:1280-95. 2009
    Large-conductance, voltage- and Ca2+-activated K+ channels (MaxiK) are broadly expressed ion channels minimally assembled by four pore-forming alpha-subunits (MaxiKalpha) and typically observed as plasma membrane proteins in various cell ..
  64. doi Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease
    Ralf Köhler
    Department of Physiology and Pharmacology, Institute of Medical Biology, Faculty of Health Science, University of Southern Denmark, J B Winsløwsvej 21 3, 5000, Odense, Denmark
    Pflugers Arch 460:343-51. 2010
    ..These findings from sequence analysis of human KCa genes, and epidemiological studies thus provide evidence that genetic variations and mutations in KCa channel genes contribute to human cardiovascular disease...
  65. ncbi Characterization of voltage-and Ca2+-activated K+ channels in rat dorsal root ganglion neurons
    Wei Li
    Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China
    J Cell Physiol 212:348-57. 2007
    ..from both whole-cell and inside-out patches are very similar to inactivating BK channels produced by co-expressing mSlo1 alpha- and hbeta2-subunits in Xenopus oocytes. Intracellular application of 0...
  66. ncbi Fluorescein angiography-guided indocyanine green angiography for the detection of feeder vessels in subfoveal choroidal neovascularization
    Y Yanagi
    Department of Ophthalmology, University of Tokyo, School of Medicine, Tokyo, Japan
    Eye (Lond) 18:474-7. 2004
    ..To compare the newly devised fluorescein angiography (FA) - guided indocyanine green angiography (ICGA) with conventional ICGA for detecting feeder vessels in subfoveal choroidal neovascularization (CNV)...
  67. doi Correlation between spectral domain optical coherence tomography findings and fluorescein angiography patterns in diabetic macular edema
    Ling Yeung
    Retina Service, Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York 10003, USA
    Ophthalmology 116:1158-67. 2009
    ..To study the relationship between spectral domain optical coherence tomography (SD-OCT) findings and fluorescein angiography (FA) patterns in patients with diabetic macular edema (DME)...
  68. ncbi [Properties of extracellular products produced by group A streptococci isolated from patient with streptococcal toxic shock syndrome]
    J Suzuki
    Department of Bioorganic Chemistry, College of Environmental Health Azabu University
    Kansenshogaku Zasshi 71:273-8. 1997
    ..The outline of discussion of the 4 products are as follows; Products were streptolysin O (SLO), proteinase, erythrogenic toxin and DNase...
  69. ncbi [Properties of extracellular products produced by group A streptococci isolated from patients with streptococcal toxic shock syndrome]
    J Suzuki
    Department of Bioorganic Chemistry, College of Environmental Health Azabu University
    Kansenshogaku Zasshi 71:1187-92. 1997
    ..The outline of the discussion of the 3 products are as follows; streptolysin O (SLO), proteinase and erythrogenic toxin...
  70. ncbi 3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for alpha-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation
    S R Thomas
    Biochemistry Unit, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, New South Wales 2050, Australia
    J Biol Chem 271:32714-21. 1996
    ..in UV-exposed micellar dispersions of alpha-TOH or in LDL incubated with soybean 15-lipoxygenase (SLO), as assessed by electron paramagnetic resonance spectroscopy. 3HAA did not inhibit SLO enzyme activity...
  71. ncbi Dietary menhaden, seal, and corn oils differentially affect lipid and ex vivo eicosanoid and thiobarbituric acid-reactive substances generation in the guinea pig
    M G Murphy
    Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada
    Lipids 34:115-24. 1999
    ..pigs were fed nonpurified diet (NP), or NP supplemented (10%, w/w) with menhaden fish oil (MO), harp seal oil (SLO), or corn oil (CO, control diet) for 23 to 28 d...
  72. ncbi Peripheral actin filaments control calcium-mediated catecholamine release from streptolysin-O-permeabilized chromaffin cells
    J M Sontag
    Centre de Neurochimie du CNRS, Unité INSERM U44, Strasbourg France
    Eur J Cell Biol 46:316-26. 1988
    Adrenal medullary chromaffin cells were permeabilized by treatment with a streptococcal cytotoxin streptolysin O (SLO) which generates pores of macromolecular dimensions in the plasma membrane...
  73. ncbi Evolution of pharyngeal behaviors and neuronal functions in free-living soil nematodes
    Jing Tzyh Alan Chiang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    J Exp Biol 209:1859-73. 2006
    ..elegans if the Ca2+-activated K+ channel SLO-1 is inactivated. C...
  74. ncbi Atypical case of Smith-Lemli-Opitz syndrome: implications for diagnosis
    B Angle
    Child Evaluation Center, Department of Pediatrics, University of Louisville, Kentucky 40202, USA
    Am J Med Genet 80:322-6. 1998
    Smith-Lemli-Opitz (SLO) syndrome is an autosomal recessive disorder comprised of recognizable facial abnormalities, growth retardation, and multiple congenital anomalies, commonly involving genitalia, second and third toe syndactyly, and ..
  75. ncbi [Immunological analysis of pseudo-positive reaction in healthy adults at anti-streptolysin O measurement by latex agglutination method]
    Hiromi Ota
    Division of Clinical Laboratory, Tottori University Hospital, Yonago 683 8504
    Rinsho Byori 53:279-83. 2005
    Streptolysin O (SLO) is a toxic immunogenic protein produced by Streptococcus pyogenes (S. pyogenes)...
  76. ncbi [Structural homology between streptolysin O (SLO) produced by streptococcus pyogenes and SLO-like protein produced by non-pathogenic streptococci and cross-reactivity of antibody against SLO-like protein to SLO]
    Kenji Iijima
    Department of Pathobiological Science and Technology, School of Health Science, Faculty of Medicine, Tottori University Yonago 683 8503
    Rinsho Byori 56:678-83. 2008
    ..Purified streptolysin O (SLO) purchased from Sigma Chemical Co...
  77. ncbi MaxiK channel mediates beta2-adrenoceptor-activated relaxation to isoprenaline through cAMP-dependent and -independent mechanisms in guinea-pig tracheal smooth muscle
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama 2 2 1, Funabashi City, Chiba 274 8510, Japan
    J Smooth Muscle Res 39:205-19. 2003
    We examined the contribution of large-conductance, Ca(2+)-sensitive K+ (MaxiK) channel to beta2-adrenoceptor-activated relaxation to isoprenaline in guinea-pig tracheal smooth muscle focusing on the role for cAMP in the coupling between ..
  78. ncbi In vivo imaging and quantitative evaluation of the rat retinal nerve fiber layer using scanning laser ophthalmoscopy
    Ichiro Kawaguchi
    Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Invest Ophthalmol Vis Sci 47:2911-6. 2006
    To determine whether scanning laser ophthalmoscopy (SLO) is useful for in vivo imaging and quantitative evaluation of rat retinal nerve fiber layer (RNFL) using an optic nerve crush model.
  79. ncbi Presynaptic Ca2+/calmodulin-dependent protein kinase II modulates neurotransmitter release by activating BK channels at Caenorhabditis elegans neuromuscular junction
    Qiang Liu
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 27:10404-13. 2007
    ..The inhibitory effect of unc-43(gf) was reversed by mutation or blockade of the BK channel SLO-1...
  80. ncbi Angiographic lesion of polypoidal choroidal vasculopathy on indocyanine green and fluorescein angiography
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Yamadaoka, Suita, Japan
    Graefes Arch Clin Exp Ophthalmol 245:1421-7. 2007
    ..The purpose of this study was to evaluate angiographic findings and compare the lesion sizes of PCV on ICGA and FA using confocal scanning laser ophthalmoscopy (SLO) and fundus camera.
  81. doi A lethal ovitrap-based mass trapping scheme for dengue control in Australia: II. Impact on populations of the mosquito Aedes aegypti
    L P Rapley
    School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Cairns, QLD 4870, Australia
    Med Vet Entomol 23:303-16. 2009
    ..populations of two types of 'lure & kill' (L&K) lethal ovitraps (LOs), the standard lethal ovitrap (SLO) and the biodegradable lethal ovitrap (BLO) were measured during three mass-trapping interventions...
  82. ncbi Virulence factor expression by Gram-positive cocci exposed to subinhibitory concentrations of linezolid
    Curtis G Gemmell
    University Department of Bacteriology and Immunology, University of Glasgow, Royal Infirmary, 84 86 Castle Street, Glasgow G4 OSF, UK
    J Antimicrob Chemother 50:665-72. 2002
    ..For S. pyogenes, strain NCTC 9994 was used to measure M protein, streptolysin O (SLO) and DNase...
  83. ncbi [Scanning laser ophthalmoscope multifocal electroretinography and microperimetry in patients with Stargardt's disease]
    G Rudolph
    Augenklinik der Ludwig Maximilians Universität München, Munchen
    Ophthalmologe 100:720-6. 2003
    We used a scanning laser ophthalmoscope (SLO) evoked multifocal electroretinography (mf-ERG) to evaluate retinal function in patients with Stargardt's disease...
  84. doi Novel alpha-KTx sites in the BK channel and comparative sequence analysis reveal distinguishing features of the BK and KV channel outer pore
    Kathleen M Giangiacomo
    Biochemistry Department, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Cell Biochem Biophys 52:47-58. 2008
    ..The large-conductance, calcium-activated (BK or Slo1) and voltage-dependent (KV) potassium channels differ in their specificity for the different alpha-KTx subfamilies...
  85. ncbi Clinical investigation of a true color scanning laser ophthalmoscope
    A Manivannan
    Department of Biomedical Physics and Bioengineering, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
    Arch Ophthalmol 119:819-24. 2001
    To show true color scanning laser ophthalmoscope (SLO) images produced by simultaneously imaging the retina with red, green, and blue lasers.
  86. ncbi Maurotoxin: a potent inhibitor of intermediate conductance Ca2+-activated potassium channels
    N A Castle
    Icagen Inc, Durham, North Carolina 27703, USA
    Mol Pharmacol 63:409-18. 2003
    ..maurus scorpion venom, was examined for its ability to inhibit cloned human SK (SK1, SK2, and SK3), IK1, and Slo1 calcium-activated potassium (K(Ca)) channels...
  87. pmc Drug-induced epigenetic changes produce drug tolerance
    Yan Wang
    Section of Neurobiology, The University of Texas at Austin, Austin, Texas, USA
    PLoS Biol 5:e265. 2007
    ..The slo gene encodes the pore-forming subunit of BK-type Ca(2+)-activated K(+) channels, which regulate many aspects of ..
  88. pmc High resolution multimodal clinical ophthalmic imaging system
    Mircea Mujat
    Physical Sciences Inc, 20 New England Business Center, Andover MA 01810, USA
    Opt Express 18:11607-21. 2010
    ..AO) retinal imager which is the first to combine high performance AO-corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact clinical ..
  89. ncbi Analysis of the retinal edema of full-thickness macular holes by scanning laser ophthalmoscopy and optical coherence tomography
    Y Akasaka
    Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 189:233-8. 1999
    ..this study was to investigate the relationship between the dark area illuminated by scanning laser ophthalmoscopy (SLO) and cystic spaces around macular holes as shown by optical coherence tomography (OCT)...
  90. pmc slo K(+) channel gene regulation mediates rapid drug tolerance
    Alfredo Ghezzi
    Section of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 101:17276-81. 2004
    ..In Drosophila, a single sedation with the anesthetic benzyl alcohol changes the expression of the slo K(+) channel gene and induces rapid drug tolerance...
  91. ncbi Relative scotomata in the "normal" eye of functionally amblyopic patients. A scanning laser ophthalmoscope (SLO) micreperimetric study
    David A Johnson
    Eye Associates of Wilmington, Wilmington, NC 28403, USA
    Binocul Vis Strabismus Q 22:17-48. 2007
    To evaluate amblyopic patients with scanning laser ophthalmoscope (SLO) microperimetry to determine whether SLO assessment and data might provide useful information in our understanding of amblyopia and determine its utility in the ..
  92. ncbi Design and synthesis of eugenol derivatives, as potent 15-lipoxygenase inhibitors
    Hamid Sadeghian
    Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad 91775 1436, Iran
    Bioorg Med Chem 16:890-901. 2008
    ..eugenol) esters were designed, synthesized, and evaluated as potential inhibitors of soybean 15-lipoxygenase (SLO). Compounds 4c, 4d 4f, 4p, and 4q showed the best IC(50) in SLO inhibition (IC(50)=1.7, 2.3, 2.1, 2.2, and 0...
  93. doi Inhibitory activity of salicylic acid on lipoxygenase-dependent lipid peroxidation
    Domenico Lapenna
    Dipartimento di Medicina e Scienze dell Invecchiamento, and Centro di Scienze dell Invecchiamento Fondazione Università G d Annunzio, Facolta di Medicina e Chirurgia, 66100 Chieti, Italy
    Biochim Biophys Acta 1790:25-30. 2009
    ..Since iron is essential for lipoxygenase activity and salicylic acid (SA) can interact with the metal, possible lipoxygenase inhibition by SA was investigated...
  94. pmc Calcium-activated potassium (BK) channels are encoded by duplicate slo1 genes in teleost fishes
    Kevin N Rohmann
    Department of Neurobiology and Behavior, Cornell University
    Mol Biol Evol 26:1509-21. 2009
    Calcium-activated, large conductance potassium (BK) channels in tetrapods are encoded by a single slo1 gene, which undergoes extensive alternative splicing...
  95. ncbi Frequency of choroidal abnormalities in neurofibromatosis type 1
    T Yasunari
    Department of Ophthalmology, Osaka City University Medical School, Osaka, Japan
    Lancet 356:988-92. 2000
    ..The development of infrared light examination with a scanning laser ophthalmoscope (SLO) and indocyanine-green fundus angiography has allowed examination of the choroid...
  96. ncbi Virulence of group A streptococci in fertile hens eggs is mainly effected by M protein and streptolysin O
    K H Schmidt
    Institute of Medical Microbiology, Hospital of the Friedrich Schiller University Jena, Germany
    Int J Med Microbiol 291:45-56. 2001
    ..The homologous recombination with plasmid pFWSLOD carrying the two slo fragments slo1 (899 base pairs in the 5' region) and slo2 (709 base pairs in the downstream part) resulted in mutants SLO3, SLO4 ..
  97. ncbi Modified astigmatism dial diagram for locating eccentric fixation in patients with central scotoma
    S Y Cohen
    Macular Degeneration and Rehabilitation Unit, Department of Ophthalmology, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, France
    Eur J Ophthalmol 13:276-80. 2003
    ..Identifying the PRL is one of the first steps in low vision rehabilitation training. We present our evaluation of a simple test designed to locate the eccentric fixation in eyes with central scotoma...
  98. ncbi Evaluation of retinal haemodynamics and retinal function after application of dorzolamide, timolol and latanoprost in newly diagnosed open-angle glaucoma patients
    Oliver Arend
    Department of Ophthalmology, Medical School, Technical University Aachen, Pauwelsstrasse 30, Aachen 52057, Germany
    Acta Ophthalmol Scand 81:474-9. 2003
    ..Haemodynamics were assessed using fluorescein angiography by means of a scanning laser ophthalmoscope (SLO). Visual function and visual field indices were evaluated during all drug treatment phases.
  99. ncbi Biosynthesis and isomerization of 11-hydroperoxylinoleates by manganese- and iron-dependent lipoxygenases
    Ernst H Oliw
    Department of Pharmaceutical Biosciences, Uppsala University, Uppsala Biomedical Center, SE 751 24 Uppsala, Sweden
    Lipids 39:319-23. 2004
    ..Rice leaf pathogen-inducible lipoxygenase, but not soybean lipoxygenase-1 (sLO-1), generated a low level of 11-HPODE (0.4%) besides its main hydroperoxide, 13(S)-HPODE, on incubation with LA...
  100. doi Retinal image location of hand, fingers, and objects during manual tasks
    George T Timberlake
    Kansas City Veterans Affairs Medical Center, Kansas City, Missouri, USA
    Optom Vis Sci 85:270-8. 2008
    A new method was developed using the scanning laser ophthalmoscope (SLO) to investigate the effects of central visual loss on eye-hand coordination in manual tasks...

Research Grants66

  1. Near Infrared Detector for Advanced Ophthalmology
    Richard Myers; Fiscal Year: 2013
    ..This receiver was then used in an adaptive optics SLO (AOSLO) at the University of Alabama, Birmingham...
  2. Anne B Fulton; Fiscal Year: 2015
    ..tomography (AO-OCT), and extrafoveal cone packing geometry will be studied using scanning laser ophthalmoscopy (AO-SLO)...
  3. High Performance Multimodal Adaptive Optics Retinal Imaging
    R Daniel Ferguson; Fiscal Year: 2011
    ..the first ever high performance AO system constructed that combines AO- corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact clinical ..
  4. Multimode Adaptive Optics Retinal Imager for Diagnosis of Age-Related Macular Deg
    Daniel Hammer; Fiscal Year: 2009
    ..AO, swept-source based Fourier domain optical coherence tomography (FDOCT), and scanning laser ophthalmoscopy (SLO). It will also include many clinical enhancements including retinal tracking for stabilized imaging...
  5. Dennis L Stevens; Fiscal Year: 2016
    ..We hypothesize that SLO facilitates calcium entry into the cardiac cell from the external environment via its pore-forming ability...
  6. Philip J Santangelo; Fiscal Year: 2014
    ..In preliminary experiments, MTRIPs, when delivered via cell membrane permeabilization with streptolysin O (SLO), bound specifically and rapidly to RNA (<10 minutes) and allowed for single RNA imaging using widefield ..
  7. Riccardo Olcese; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Large-conductance Ca2+- and voltage-gated K+ (Slo1 BK) channels play numerous physiological and pathophysiological roles and their allosteric gating mechanism is subject to modulation by a variety of ..
  8. Michael G Caparon; Fiscal Year: 2014
    ..The most widely distributed group is the CDC family of which Streptolysin O (SLO) is a prominent member...
  9. Rodney K Tweten; Fiscal Year: 2015
    ..It was recently shown that the CDC of Streptococcus pyogenes, streptolysin O (SLO), transports a specific protein into eukaryotic cells by a pore-independent mechanism...
  10. Alexey V Zaitsev; Fiscal Year: 2015
    ..Our preliminary results reveal regional differences in Slo 2.1 expression which may explain the electrophysiological gradients...
  11. Nigel S Atkinson; Fiscal Year: 2016
    ..The highly conserved slowpoke (slo) gene encodes BK-type Ca2+-activated K+ channels, which integrate Ca2+ signals and electrical signals and are ..
  12. Synucleins and Potassium Channel Function
    STACEY MACFARLANE; Fiscal Year: 2001
    ..In recent years, the calcium-activated potassium channel (Slo), which plays a particular role in repolarization and, thus, neurotransmission at the neuronal synapse, has been ..
  13. Hui Cai; Fiscal Year: 2016
    ..Maxi K, also referred as to BK or Slo, is the other major potassium channel in the distal nephron (9)...
  14. SUBUNITS INTERACTION IN THE FUNCTION OF BK CHANNELS
    Jianmin Cui; Fiscal Year: 2013
    ..These channels are composed of the pore-forming, voltage- and Ca2+ -sensing a subunit that is encoded by a single Slo1 gene and four types of auxiliary [unreadable] subunit ([unreadable]1-4)...
  15. Alex M Dopico; Fiscal Year: 2016
    ..We recently showed that ethanol actions on BK result from a basic interaction among the channel-forming (slo) subunit, the BK natural ligand (Ca2+) and the drug, yet several other elements, such as posttranslational ..
  16. HAND HELD SLO FOR OCULAR IMAGING AND VISION ASSESSMENT
    MAURICE RYNDERS; Fiscal Year: 1999
    Scanning laser ophthalmoscopes (SLO) offer many advantages over standard ophthalmoscopes, such as high contrast and high resolution fundus imaging without dilation, simultaneous fundus imaging and indocyanine green (ICG) angiography, and ..
  17. Christopher J Lingle; Fiscal Year: 2015
    The calcium and voltage regulated BK-type K+ channel encoded by the Slo1 gene is a widely expressed ion channel impacting on regulation of excitability in a variety of tissues...
  18. Gene transfer to treat urinary urgency frequency nocturia &incontinence
    Moses Tar; Fiscal Year: 2012
    ..that has completed the first, and only, phase I safety trial using plasmid DNA transfer with a non-specific gene MaxiK potassium channel promoter to treat urinary urgency, frequency, nocturia, and incontinence also known as ..
  19. Molecular Basis of K+ Current During Secretion
    Keith Nehrke; Fiscal Year: 2002
    ..The molecular identity of each of these channels remains unknown. Until recently, the large-conductance BK (slo) channel was thought to carry the majority of the calcium-activated potassium current during stimulated secretion...
  20. David H Brainard; Fiscal Year: 2016
    ..a variety of imaging modalities, including conventional and two-photon confocal microscopy, multi-electrode array recording from in vitro tissue, and confocal SLO combined with spectral OCT imaging of in vivo retina.
  21. MULTI-WAVELENGTH LASER ARRAYS FOR MEDICAL IMAGING
    JACK JEWELL; Fiscal Year: 1993
    ..wavelength, which are efficiently combined and fed through an optical fiber into a scanning laser ophthalmoscope (SLO)...
  22. Roles and mechanisms of Slo and Slack Channels in Brain
    Leonard Kaczmarek; Fiscal Year: 2005
    ..BK(Ca) channels are encoded by the Slo gene...
  23. Mutants Showing SLO-1 Synaptic Mislocalization
    Zhao Wen Wang; Fiscal Year: 2005
    ..In C. elegans, loss-of-function mutations of the BK channel (SLO-1) results in increased neurotransmitter release (Wang et al...
  24. Hign Performance MEMS Deformable Mirror for Adaptive Optics Retinal Imaging
    MICHAEL HELMBRECHT; Fiscal Year: 2009
    ..laid out in the NEI National Plan by developing a critical component in AO systems that will be used in AO-equipped SLO and OCT systems...
  25. ROLAND THEODORE SMITH; Fiscal Year: 2014
    ..the research team plans to acquire hyperspectral, photographic, AF and infrared scanning laser ophthalmoscope (SLO), and spectral domain optical coherence tomography (SD-OCT) images of all phenotypes of AMD, with analysis of the ..
  26. Design of Slack Channel Activators
    Heike Wulff; Fiscal Year: 2012
    ..By screening various pharmacophores known to activate the related large-conductance Ca2+-activated K+ channel BK (Slo1, Maxi-K) it was recently discovered that biphenylthioles and 4-arylquinolinones activate Slack channels in the low ..
  27. SpyA, a novel S. pyogenes ADP-ribosyltransferase
    STEPHEN L MOSELEY; Fiscal Year: 2010
    ..that SpyA gains entrance into the eukaryotic cell using a pore produced by the cholesterol dependent cytolysin SLO. The goals of this grant are (1) to determine the role of SpyA in streptococcal infections, (2) to characterize its ..
  28. Stabilized Adaptive Optics Imaging Laser Microsurgery
    Daniel Hammer; Fiscal Year: 2004
    ..The diagnostic instrument will use scanning laser ophthalmoscopy (SLO) at its core, with unique and necessary enhancements of adaptive optics and retinal tracking used to increase ..
  29. Duke Geem; Fiscal Year: 2014
    ..Previous research has focused on how secondary lymphoid organ (SLO) APCs induce T cell differentiation, which has led to the widely accepted model that steady-state intestinal CD4+ T ..
  30. CHRISTOPHER ANDERSON CLARK; Fiscal Year: 2016
    ..Using the Indiana University AO SLO, we intend to count the underlying cone numbers across the retina at various eccentricities...
  31. CORE GRANT FOR VISION RESEARCH
    Christopher W Tyler; Fiscal Year: 2011
    ..imaging techniques to these problems, including the diverse techniques of whole-head VEP, MRI, fMRI, DTI, and SLO imaging, with a recent focus on integrating many or most of these methodologies into a large-scale multimodal ..
  32. BENJAMIN R TROUTWINE; Fiscal Year: 2015
    ..Previous work in our lab showed that induction of the slo gene, which encodes a BK channel, underlies functional tolerance: slo mutants fail to acquire tolerance, and ..
  33. LIGIA G TORO DE STEFANI; Fiscal Year: 2015
    ..responsiveness, and sensitivity to pharmacological agents with its plasma membrane counterpart known as BKCa (or MaxiK), we expect that mitoBKCa is assembled like BKCa by four pore-forming a subunits with a monomeric mass of ~125 kDa...
  34. Biocompatibility of thermo-responsive hydrogel ocular drug delivery system
    JENNIFER J KANG MIELER; Fiscal Year: 2010
    ..To evaluate biocompatibility, electroretinogram (ERG) responses, scanning laser ophthalmoscope (SLO)-imaging blood flow measurements, spectral domain optical coherence tomography (SD-OCT) imaging and histological ..
  35. Zhao Wen Wang; Fiscal Year: 2016
    ..were isolated as suppressors of a lethargic phenotype caused by expressing a gain-of-function (gf) isoform of SLO-1, the C. elegans BK channel...
  36. Smith-Lemli-Opitz syndrome and Inborn Errors of Cholesterol Synthesis
    ROBERT DAVID STEINER; Fiscal Year: 2013
    ..Importantly, the Conference will be held in conjunction with the SLO/RSH Family and Medical biannual meeting...
  37. Automated diabetic retinopathy screening system
    Peter Soliz; Fiscal Year: 2009
    ..These algorithms have been tested using a single modality (pixel format, SLO, standard funduscope, color, red free, etc...
  38. The molecular basis for the action of ethanol on the BK channel
    Scott J Davis; Fiscal Year: 2012
    ..elegans discovered that null mutations in the worm ortholog of the BK channel, SLO-1, produced an extreme level of resistance to behavioral intoxication...
  39. Cellular Physiology of Podocytes
    Stuart E Dryer; Fiscal Year: 2010
    ..of the TRPC family, especially TRPC6;and large-conductance (BKCa-type) Ca2+-activated K+ channels encoded by the Slo1 gene...
  40. Andrea L Meredith; Fiscal Year: 2016
    ..The large conductance Ca2+-activated K+ channel (BK), encoded by the Kcnma1 gene, is an essential regulator of circadian physiological and behavioral rhythms in mouse and fly...
  41. STABILIZED IMAGING FOR THE SCANNING LASER OPHTHALMOSCOPE
    R Ferguson; Fiscal Year: 2001
    ..the Retinal Tracking (RT) technology demonstrated in Phase I into an advanced Scanning 1aaser Ophthalmoscope (SLO), and to demonstrate the clinical value of that system...
  42. MATTHEW JOHN BILLARD; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Lymphocyte migration through the secondary lymphoid organs (SLO) is influenced by chemotactic cues and a network of matrix and stromal cells...
  43. Plasticity of Neuronal Function and Form in Drosophila
    Chun Fang Wu; Fiscal Year: 2012
    ..Striking plasticity in restoring synaptic stability is revealed by slo and Sh mutations, which provide opportunities to identify interacting genes in signal transduction pathways in the ..
  44. MHC Class I Antigen Presentation in Viral Infections
    Luis J Sigal; Fiscal Year: 2011
    ..antigens (Ags), proposes that dendritic cells carry Ags from infected tissues to secondary lymphoid organs (SLO) where CD8+ T cells are primed...
  45. Dhasakumar S Navaratnam; Fiscal Year: 2016
    ..The channels consist of the Slo protein and a variable number of associated proteins The proposal seeks to determine how BK channels are localized ..
  46. MaxiK channel biology
    LIGIA TORO DE STEFANI; Fiscal Year: 2009
    Large conductance, Ca2+-activated K+ channels (MaxiK, BK) are key regulators of a plethora of cell functions including vascular tone, neuronal function, and immunity...
  47. STEROL METABOLISM & DIETARY CHOLESTEROL IN SLO SYNDROME
    WILLIAM CONNOR; Fiscal Year: 2002
    ..Developmental testing will be performed. ..
  48. A NOVEL PH DEPENDENT POTASSIUM CHANNEL IN MAMMALIAN SPERM
    Celia Santi; Fiscal Year: 2009
    The SLO3 channel is a member of the high conductance SLO potassium (K+) channel family and is activated by both voltage and intracellular pH (pHi). The SLO3 channel is found only in mammals and is located exclusively in testis...
  49. Chiou Fen Chuang; Fiscal Year: 2016
    ..nsy-5 neural network to coordinate stochastic AWC subtype choice (Aim 1), investigate the role of Ca2+-activated SLO K+ channels and newly identified MOK (modifier of K+ channel) molecules in AWC subtype choice (Aim 2), and identify ..
  50. DIGITAL RESOLUTION IMPROVEMENT OF SLO ANGIOGRAMS
    Timothy Holmes; Fiscal Year: 2002
    ..of vasculature and other structures in the fundus, using fluorescent dyes with the scanning laser ophthalmoscope (SLO)...
  51. Novel Piezoelectric Deformable Mirror Systems for Retinal Imaging
    XINGTAO contact WU; Fiscal Year: 2010
    ..into conventional ophthalmic instruments including fundus camera, confocal Scanning Laser Ophthalmoscope (SLO) and Optical Coherence Tomography (OCT) systems and to be widely used in biomedical microscopes and laboratory ..
  52. INBORN ERRORS IN BILE ACID SYNTHESIS
    Sarah Shefer; Fiscal Year: 2000
    ..e. the Smith-Lemli-Opitz (SLO) syndrome, sitosterolemia, and cerebrotendinous xanthomatosis (CTX)...
  53. Low-cost High-resolution fundus camera
    PETER NONE SOLIZ; Fiscal Year: 2010
    ..specific aims are to integrate the low-cost low-order aberrations compensator into a scanning laser ophthalmoscope (SLO)...
  54. FEASIBILITY OF PRENATAL SCREENING FOR SLO SYNDROME
    George Knight; Fiscal Year: 2003
    ..The study will also aid in refining prevalence estimates by race and ethnicity, and will determine whether several rare disorders in the cholesterol biosynthetic pathway would be detectable. ..
  55. Proteomic Approaches to Type l Diabetes Progression
    MARK CHANCE; Fiscal Year: 2005
    ..In Aim 2, using immuno-precipitation of the Maxi-K channel (Slo gene product) followed by protease digestion and LC-mass spectrometry, we will determine which Slo gene splice ..
  56. HORMONAL REGULATION OF MYOMETRIUM ION CHANNELS
    Enrico Stefani; Fiscal Year: 2003
    ..ion channel expression and function in uterine smooth muscle, with special emphasis on Ca2+ dependent K+ channels (MaxiK), fast transient K+ channels (Kv4.3, ITO) and L-type Ca2+ channels...
  57. VASO-OCCLUSIVE PROCESSES IN SICKLE CELL RETINOPATHY
    Gerard Lutty; Fiscal Year: 2006
    ..transient retention of sickled RBCs in normal rats as observed with the Rodenstock Scanning Laser Ophthalmoscope (SLO)...
  58. Circadian control of behavior in Drosophila
    Steve Kay; Fiscal Year: 2004
    ..The Specific Aims cover the analysis of mRNA and protein temporal profiles of slo and slob, two candidate genes putatively involved in circadian control of behavior; locomotor behavior analysis of ..
  59. Analysis of cSlo interacting proteins in the inner ear
    Dhasakumar Navaratnam; Fiscal Year: 2005
    ..extend on the recent experimental evidence relating the primary structure of the calcium gated potassium channel, Slo, to electrical resonance; a phenomenon that allows individual hair cells to discriminate between different ..
  60. Dissecting lymphocyte chemotaxis using synthetic chemokine-releasing microspheres
    DARRELL IRVINE; Fiscal Year: 2009
    ..control the 3D navigation of lymphocytes through tissues and their localization in secondary lymphoid organs (SLO) remains poorly defined...
  61. ROLE OF SLO GENES & ION CHANNELS IN NEURONAL DEVELOPMENT
    ANGELES RIBERA; Fiscal Year: 2002
    ..The principal goals of the proposed research are to isolate cDNAs corresponding to the Xenopus orthologue of Slo (xSlo). The Slo gene encodes the pore-forming "-subunit of large conductance potassium (BK) channels...
  62. Mechanisms of slowpoke in regulating circadian behavior
    Jessie Chu; Fiscal Year: 2005
    ..We found Drosophila slowpoke (slo) or its vertebrate homolog, Kcnmal, to be one of the few genes that is controlled by the clock in both species...
  63. MEMBRANE DEFECT IN THE SLO SYNDROME
    Thomas Tulenko; Fiscal Year: 2005
    ..In addition, we expect to validate the DHCR7 k/o mouse model of SLOS and thereby provide greater opportunity for us and others to study SLOS in the hope of providing clinical relief to patients faced with this disease. ..
  64. ETHANOL ACTIONS ON SLO CHANNELS FROM ARTERIES VS BRAIN
    Alejandro Dopico; Fiscal Year: 2000
    ..This dichotomy remained when EtOH action was studied on two 99% identical cloned channels encoded by slo genes, inserted in the same proteo-lipid environment: 50 mM EtOH inhibits channels from arterial smooth muscle (..
  65. Genetic Studies of Cardiac Pacemaking in the Zebrafish
    Calum MacRae; Fiscal Year: 2004
    ..The zebrafish mutant slo mo (smo) displays heritable intrinsic bradycardia but exhibits no other developmental defect...
  66. TUNABLE-WAVELENGTH SCANNING LASER OPTHALMOSCOPE
    PETER MOULTON; Fiscal Year: 1991
    ..the diagnostic capabilities of one of the newest retinal imaging instruments, the scanning laser ophthalmoscope (SLO), can be enhanced by the use of near-infrared, wavelength-tunable laser source...