KRT23

Summary

Gene Symbol: KRT23
Description: keratin 23
Alias: CK23, HAIK1, K23, keratin, type I cytoskeletal 23, CK-23, cytokeratin 23, histone deacetylase inducible keratin 23, hyperacetylation-inducible type I keratin, keratin 23 (histone deacetylase inducible), keratin 23, type I, type I intermediate filament cytokeratin
Species: human
Products:     KRT23

Top Publications

  1. Zhang J, Wang L, Huang H, Nelson M, Smith D. Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. Genes Chromosomes Cancer. 2001;30:123-35 pubmed
    ..The gene is named K23 (for human type I Keratin 23, KRT23). K23 mRNA was highly induced by NaBu in different pancreatic cancer cells...
  2. Hesse M, Magin T, Weber K. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. J Cell Sci. 2001;114:2569-75 pubmed
    ..We describe the limits of our analysis and discuss the striking unevenness of pseudogene derivation in the IF multigene family. Finally, we propose to extend the nomenclature of Moll and colleagues to any novel keratin. ..
  3. Tolstonog G, Sabasch M, Traub P. Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function. DNA Cell Biol. 2002;21:213-39 pubmed
    ....
  4. Birkenkamp Demtroder K, Mansilla F, Sørensen F, Kruhøffer M, Cabezon T, Christensen L, et al. Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro. Mol Oncol. 2007;1:181-95 pubmed publisher
    ..Keratin23 expression correlated significantly with transcription factor CEBPB. In conclusion, Keratin23 expression is a novel and important difference between microsatellite-stable and microsatellite-instable colon cancers. ..
  5. Liffers S, Maghnouj A, Munding J, Jackstadt R, Herbrand U, Schulenborg T, et al. Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε. BMC Cancer. 2011;11:137 pubmed publisher
    ..8 and 18, heat shock proteins 60 and 70, plectin 1, as well as 14-3-3ε and γ as novel proteins present in the KRT23-interacting complex...
  6. Li P, Zhang Y, Xie B, Zhang Y, Hao J, Wang Y, et al. Structural and Mechanistic Insights into the Improvement of the Halotolerance of a Marine Microbial Esterase by Increasing Intra- and Interdomain Hydrophobic Interactions. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..M3" represents a mutation in loop 1 of the CAP domain in which residues R22-K23-T24 of E40 are replaced by residues Y22-K23-H24-L25-S26 of Est2...
  7. Buehl C, Deng X, Luo J, Buranasudja V, Hazbun T, Kuo M. A Failsafe for Sensing Chromatid Tension in Mitosis with the Histone H3 Tail in Saccharomyces cerevisiae. Genetics. 2017;: pubmed publisher
    ..Mutations to K14 and K23 ameliorate the mitotic defects resulting from tension sensing motif mutations...
  8. Broussard E, Kim R, Wiley J, Marquez J, Annis J, Pritchard D, et al. Identification of putative immunologic targets for colon cancer prevention based on conserved gene upregulation from preinvasive to malignant lesions. Cancer Prev Res (Phila). 2013;6:666-74 pubmed publisher
    ..Silencing the most highly upregulated genes, CDH3, CLDN1, KRT23, and MMP7, in adenoma and CRC cell lines resulted in a significant decrease in viability (P < 0...
  9. Yang Q, Feng M, Ma X, Li H, Xie W. Gene expression profile comparison between colorectal cancer and adjacent normal tissues. Oncol Lett. 2017;14:6071-6078 pubmed publisher
    ..However, subsequent gene function studies are required to verify these findings...
  10. Suzuki A, Ji G, Numabe Y, Muramatsu M, Gomi K, Kanazashi M, et al. Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. Biochem Biophys Res Commun. 2004;317:887-92 pubmed
    ..with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic ..

Detail Information

Publications15

  1. Zhang J, Wang L, Huang H, Nelson M, Smith D. Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. Genes Chromosomes Cancer. 2001;30:123-35 pubmed
    ..The gene is named K23 (for human type I Keratin 23, KRT23). K23 mRNA was highly induced by NaBu in different pancreatic cancer cells...
  2. Hesse M, Magin T, Weber K. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. J Cell Sci. 2001;114:2569-75 pubmed
    ..We describe the limits of our analysis and discuss the striking unevenness of pseudogene derivation in the IF multigene family. Finally, we propose to extend the nomenclature of Moll and colleagues to any novel keratin. ..
  3. Tolstonog G, Sabasch M, Traub P. Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function. DNA Cell Biol. 2002;21:213-39 pubmed
    ....
  4. Birkenkamp Demtroder K, Mansilla F, Sørensen F, Kruhøffer M, Cabezon T, Christensen L, et al. Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro. Mol Oncol. 2007;1:181-95 pubmed publisher
    ..Keratin23 expression correlated significantly with transcription factor CEBPB. In conclusion, Keratin23 expression is a novel and important difference between microsatellite-stable and microsatellite-instable colon cancers. ..
  5. Liffers S, Maghnouj A, Munding J, Jackstadt R, Herbrand U, Schulenborg T, et al. Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε. BMC Cancer. 2011;11:137 pubmed publisher
    ..8 and 18, heat shock proteins 60 and 70, plectin 1, as well as 14-3-3ε and γ as novel proteins present in the KRT23-interacting complex...
  6. Li P, Zhang Y, Xie B, Zhang Y, Hao J, Wang Y, et al. Structural and Mechanistic Insights into the Improvement of the Halotolerance of a Marine Microbial Esterase by Increasing Intra- and Interdomain Hydrophobic Interactions. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..M3" represents a mutation in loop 1 of the CAP domain in which residues R22-K23-T24 of E40 are replaced by residues Y22-K23-H24-L25-S26 of Est2...
  7. Buehl C, Deng X, Luo J, Buranasudja V, Hazbun T, Kuo M. A Failsafe for Sensing Chromatid Tension in Mitosis with the Histone H3 Tail in Saccharomyces cerevisiae. Genetics. 2017;: pubmed publisher
    ..Mutations to K14 and K23 ameliorate the mitotic defects resulting from tension sensing motif mutations...
  8. Broussard E, Kim R, Wiley J, Marquez J, Annis J, Pritchard D, et al. Identification of putative immunologic targets for colon cancer prevention based on conserved gene upregulation from preinvasive to malignant lesions. Cancer Prev Res (Phila). 2013;6:666-74 pubmed publisher
    ..Silencing the most highly upregulated genes, CDH3, CLDN1, KRT23, and MMP7, in adenoma and CRC cell lines resulted in a significant decrease in viability (P < 0...
  9. Yang Q, Feng M, Ma X, Li H, Xie W. Gene expression profile comparison between colorectal cancer and adjacent normal tissues. Oncol Lett. 2017;14:6071-6078 pubmed publisher
    ..However, subsequent gene function studies are required to verify these findings...
  10. Suzuki A, Ji G, Numabe Y, Muramatsu M, Gomi K, Kanazashi M, et al. Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. Biochem Biophys Res Commun. 2004;317:887-92 pubmed
    ..with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic ..
  11. Fatehi M, Raja M, Carter C, Soliman D, Holt A, Light P. The ATP-sensitive K(+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity. Diabetes. 2012;61:241-9 pubmed publisher
    ..human K(ATP) channels or glutathione S-transferase and NBD2 fusion proteins containing the E23/S1369 (nonrisk) or K23/A1369 (risk) variant haplotypes...
  12. Lang V, Fatehi M, Light P. Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A. Pharmacogenet Genomics. 2012;22:206-14 pubmed publisher
    ..Our previous studies showed that KATP channel inhibition by the A-site sulfonylurea gliclazide was increased in the K23/A1369 haplotype...
  13. Birkenkamp Demtroder K, Hahn S, Mansilla F, Thorsen K, Maghnouj A, Christensen R, et al. Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells. PLoS ONE. 2013;8:e73593 pubmed publisher
    Keratin 23 (KRT23) is strongly expressed in colon adenocarcinomas but absent in normal colon mucosa...
  14. Wang P, Tang S, Nemr K, Flick R, Yan J, Mahadevan R, et al. Refined experimental annotation reveals conserved corrinoid autotrophy in chloroform-respiring Dehalobacter isolates. ISME J. 2017;11:626-640 pubmed publisher
    ..Similar to D. restrictus strain PER-K23, strains CF and DCA require arginine, histidine and threonine for growth, although the corresponding biosynthesis ..
  15. Régnier M, Polizzi A, Lippi Y, Fouché E, Michel G, Lukowicz C, et al. Insights into the role of hepatocyte PPARα activity in response to fasting. Mol Cell Endocrinol. 2017;: pubmed publisher
    ..Interestingly, we identified novel PPARα-sensitive genes, including Cxcl-10, Rab30, and Krt23. We also found that liver phospholipid remodelling was a novel fasting-sensitive pathway regulated by PPARα...