KRT23

Summary

Gene Symbol: KRT23
Description: keratin 23
Alias: CK23, HAIK1, K23, keratin, type I cytoskeletal 23, CK-23, cytokeratin 23, histone deacetylase inducible keratin 23, hyperacetylation-inducible type I keratin, keratin 23 (histone deacetylase inducible), keratin 23, type I, type I intermediate filament cytokeratin
Species: human

Top Publications

  1. ncbi Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells
    J S Zhang
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, Minnesota 55905, USA
    Genes Chromosomes Cancer 30:123-35. 2001
  2. ncbi Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18
    M Hesse
    Institute of Genetics, Division of Molecular Genetics and Bonner Forum Biomedizin, University of Bonn, Germany
    J Cell Sci 114:2569-75. 2001
  3. doi Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro
    Karin Birkenkamp-Demtroder
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Brendstrupgaardsvej, DK 8200 Aarhus N, Denmark
    Mol Oncol 1:181-95. 2007
  4. ncbi Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function
    Genrich V Tolstonog
    Max Planck Institut für Zellbiologie, Rosenhof, 68526 Ladenburg, Germany
    DNA Cell Biol 21:213-39. 2002
  5. pmc Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε
    Sven T Liffers
    Medizinisches Proteom Center, Ruhr University Bochum Zentrum fuer Klinische Forschung, Universitaetsstr 150, 44780 Bochum, Germany
    BMC Cancer 11:137. 2011
  6. pmc Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8
    Joanna Smeeton
    Program in Developmental and Stem Cell Biology, and Departments of Paediatrics, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Am Soc Nephrol 27:1465-77. 2016
  7. ncbi Hematology grants K08 and K23
    David M Bodine
    National Institutes of Health, 49 Convent Drive, Building 49, Room 3A14, MSC4442, Bethesda, MD 20892 4442, USA
    Hematology Am Soc Hematol Educ Program . 2005
  8. ncbi Large plasmid pCAR2 and class II transposon Tn4676 are functional mobile genetic elements to distribute the carbazole/dioxin-degradative car gene cluster in different bacteria
    Masaki Shintani
    Biotechnology Research Center, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Appl Microbiol Biotechnol 67:370-82. 2005
  9. doi Multiplexed parallel reaction monitoring targeting histone modifications on the QExactive mass spectrometer
    Hui Tang
    Department of Pharmacology, University of Texas Medical Branch, Galveston, Texas 77555, United States
    Anal Chem 86:5526-34. 2014
  10. doi Microarray-based detection and expression analysis of extracellular matrix proteins in drug‑resistant ovarian cancer cell lines
    Radosław Januchowski
    Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań 61 781, Poland
    Oncol Rep 32:1981-90. 2014

Research Grants

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
  2. Shervin Assassi; Fiscal Year: 2014
  3. BRIAN JAMES MICKEY; Fiscal Year: 2015
  4. CYNTHIA T MCEVOY; Fiscal Year: 2016
  5. Enrico M Novelli; Fiscal Year: 2016
  6. Renée A Shellhaas; Fiscal Year: 2014
  7. Cynthia D Morris; Fiscal Year: 2016
  8. ANGELA MEI TIN LEUNG; Fiscal Year: 2015
  9. Brian Till; Fiscal Year: 2016
  10. KELLY VICTORIA LIANG; Fiscal Year: 2016

Scientific Experts

Detail Information

Publications85

  1. ncbi Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells
    J S Zhang
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, Minnesota 55905, USA
    Genes Chromosomes Cancer 30:123-35. 2001
    ..The gene is named K23 (for human type I Keratin 23, KRT23). K23 mRNA was highly induced by NaBu in different pancreatic cancer cells...
  2. ncbi Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18
    M Hesse
    Institute of Genetics, Division of Molecular Genetics and Bonner Forum Biomedizin, University of Bonn, Germany
    J Cell Sci 114:2569-75. 2001
    ..We describe the limits of our analysis and discuss the striking unevenness of pseudogene derivation in the IF multigene family. Finally, we propose to extend the nomenclature of Moll and colleagues to any novel keratin...
  3. doi Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro
    Karin Birkenkamp-Demtroder
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Brendstrupgaardsvej, DK 8200 Aarhus N, Denmark
    Mol Oncol 1:181-95. 2007
    ..Keratin23 expression correlated significantly with transcription factor CEBPB. In conclusion, Keratin23 expression is a novel and important difference between microsatellite-stable and microsatellite-instable colon cancers...
  4. ncbi Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function
    Genrich V Tolstonog
    Max Planck Institut für Zellbiologie, Rosenhof, 68526 Ladenburg, Germany
    DNA Cell Biol 21:213-39. 2002
    ....
  5. pmc Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε
    Sven T Liffers
    Medizinisches Proteom Center, Ruhr University Bochum Zentrum fuer Klinische Forschung, Universitaetsstr 150, 44780 Bochum, Germany
    BMC Cancer 11:137. 2011
    ..Using this cellular model system, we searched for new Smad4 targets comparing nuclear subproteomes derived from Smad4 re-expressing and Smad4 negative SW480 cells...
  6. pmc Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8
    Joanna Smeeton
    Program in Developmental and Stem Cell Biology, and Departments of Paediatrics, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Am Soc Nephrol 27:1465-77. 2016
    ..of p38MAPK activity in murine inner medullary collecting duct 3 (mIMCD3) cells decreased expression of Wnt11, Krt23, and Slo4c1 DUSP8 overexpression in mIMCD3 cells significantly inhibited p38MAPK activation and the expression of ..
  7. ncbi Hematology grants K08 and K23
    David M Bodine
    National Institutes of Health, 49 Convent Drive, Building 49, Room 3A14, MSC4442, Bethesda, MD 20892 4442, USA
    Hematology Am Soc Hematol Educ Program . 2005
    The first National Institutes of Health (NIH) grant awarded to physician scientists is often a K08 or K23 award. This chapter is designed for the Hematology Fellow who is preparing for an independent faculty position in 3-5 years...
  8. ncbi Large plasmid pCAR2 and class II transposon Tn4676 are functional mobile genetic elements to distribute the carbazole/dioxin-degradative car gene cluster in different bacteria
    Masaki Shintani
    Biotechnology Research Center, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Appl Microbiol Biotechnol 67:370-82. 2005
    ..putida strain HS01 that was a transconjugant from mating between the carbazole-degrader Pseudomonas sp. strain K23 and P. putida strain DS1...
  9. doi Multiplexed parallel reaction monitoring targeting histone modifications on the QExactive mass spectrometer
    Hui Tang
    Department of Pharmacology, University of Texas Medical Branch, Galveston, Texas 77555, United States
    Anal Chem 86:5526-34. 2014
    ..tryptic peptides, we identified novel H3 K18 methylation, H3 K27 monomethyl/acetyl duel modifications, H2B K23 acetylation, and H4 K20 acetylation in mammalian histones...
  10. doi Microarray-based detection and expression analysis of extracellular matrix proteins in drug‑resistant ovarian cancer cell lines
    Radosław Januchowski
    Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań 61 781, Poland
    Oncol Rep 32:1981-90. 2014
    ..The expression of seven genes decreased very significantly: ITGA1, COL1A2, LAMA2, GPC3, KRT23, VIT and HMCN1...
  11. doi Prox1 regulates Olig2 expression to modulate binary fate decisions in spinal cord neurons
    Valeria Kaltezioti
    Center for Basic Research, Biomedical Research Foundation of the Academy of Athens BRFAA, 115 27, Athens, Greece and
    J Neurosci 34:15816-31. 2014
    ..showed that endogenous Prox1 directly binds to the proximal promoter of the Olig2 gene locus, as well as to the K23 enhancer, which drives Olig2 expression in the pMN domain...
  12. doi The vascular surgeon-scientist: a 15-year report of the Society for Vascular Surgery Foundation/National Heart, Lung, and Blood Institute-mentored Career Development Award Program
    Melina R Kibbe
    Division of Vascular Surgery, Northwestern University, Chicago, Ill Electronic address
    J Vasc Surg 61:1050-7. 2015
    ..career development program that provides a financial supplement to surgeon-scientists receiving NIH K08 or K23 career development awards...
  13. pmc Comparison of Two Commercial Tick-Borne Encephalitis Virus IgG Enzyme-Linked Immunosorbent Assays
    Fabian H Weissbach
    Transplantation and Clinical Virology, Department of Biomedicine, University of Basel, Basel, Switzerland
    Clin Vaccine Immunol 22:754-60. 2015
    ..Both assays use whole TBEV antigens, but they differ in viral strains (Neudoerfl for ELISA-1 and K23 for ELISA-2) and cutoff values...
  14. pmc Molecular Basis of the Divergent Immunogenicity of Two Pediatric Tick-Borne Encephalitis Virus Vaccines
    Yvonne Beck
    Vaccine R and D, Baxter BioScience, Orth an der Donau, Austria Pfizer Biotech, Dublin, Ireland
    J Virol 90:1964-72. 2015
    ..FSME-Immun Junior is based on the Neudörfl (Nd) strain, whereas Encepur Children is based on the Karlsruhe (K23) strain...
  15. doi Simple Epithelial Keratins
    Pavel Strnad
    Department of Internal Medicine III and IZKF, University Hospital Aachen, Aachen, Germany Electronic address
    Methods Enzymol 568:351-88. 2016
    ..SEK filaments are composed of obligate heteropolymers of type II (K7, K8) and type I (K18-K20, K23) keratins...
  16. pmc Sister Dehalobacter Genomes Reveal Specialization in Organohalide Respiration and Recent Strain Differentiation Likely Driven by Chlorinated Substrates
    Shuiquan Tang
    Department of Chemical Engineering and Applied Chemistry, University of Toronto Toronto, ON, Canada
    Front Microbiol 7:100. 2016
    ..compared to three other available organohalide-respiring Dehalobacter genomes (Dehalobacter restrictus strain PER-K23, Dehalobacter sp. strain E1 and Dehalobacter sp...
  17. doi Keratin 23 is a stress-inducible marker of mouse and human ductular reaction in liver disease
    Nurdan Guldiken
    Department of Internal Medicine III, RWTH University Hospital Aachen, Germany Interdisciplinary Center for Clinical Research IZKF, RWTH University Hospital Aachen, Germany
    J Hepatol 65:552-9. 2016
    ..In the present study we aimed to characterize K23 in the liver.
  18. doi Initial Molecular Recognition Steps of McjA Precursor during Microcin J25 Lasso Peptide Maturation
    Nadine Assrir
    Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Universite Paris Sud, Université Paris Saclay, 1 Avenue de la Terrasse, 91190, Gif sur Yvette, France
    Chembiochem 17:1851-1858. 2016
    ..Moreover, we demonstrated that residues K23-Q34 in the N-terminal McjA leader peptide tend to adopt a helical conformation in the presence of membrane mimics, ..
  19. pmc LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis
    Gemma Odena
    Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Sci Rep 6:35610. 2016
    ..We performed transcriptome studies and identified keratin 23 (KRT23) as a new ductular cell marker. KRT23 expression correlated with mortality and LPS serum levels...
  20. pmc Refined experimental annotation reveals conserved corrinoid autotrophy in chloroform-respiring Dehalobacter isolates
    Po Hsiang Wang
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
    ISME J . 2016
    ..Similar to D. restrictus strain PER-K23, strains CF and DCA require arginine, histidine and threonine for growth, although the corresponding biosynthesis ..
  21. pmc Interaction with the DNA Repair Protein Thymine DNA Glycosylase Regulates Histone Acetylation by p300
    Ryan A Henry
    Cancer Epigenetics and Cancer Biology Programs, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, United States
    Biochemistry 55:6766-6775. 2016
    ..with the CH3 domain of p300 to allosterically promote p300 activity to specific lysines on histone H3 (K18 and K23)...
  22. pmc Absolute bioavailability and pharmacokinetics of linezolid in hospitalized patients given enteral feedings
    Paul Beringer
    School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Antimicrob Agents Chemother 49:3676-81. 2005
    ..analysis incorporating linear and nonlinear elimination pathways were compared between groups: F, Ka, Vs, K23, K32, Vmax, Km, and K20 (bioavailability, absorption rate constant, volume of central compartment normalized to ..
  23. pmc Chaperone-mediated acetylation of histones by Rtt109 identified by quantitative proteomics
    Nebiyu Abshiru
    Institute for Research in Immunology and Cancer, Universite de Montreal, Montreal, Canada
    J Proteomics 81:80-90. 2013
    ..Our analyses showed that Rtt109-Vps75 preferentially acetylates H3 K9 and K23, the former residue being the major acetylation site...
  24. pmc Outcome evaluation of the National Cancer Institute career development awards program
    Julie L Mason
    National Cancer Institute, Rockville, MD, USA
    J Cancer Educ 28:9-17. 2013
    ..The evaluation covered seven NCI mechanisms (K01, K07, K08, K11, K22, K23, and K25) between 1980 and 2008...
  25. pmc Identification of putative immunologic targets for colon cancer prevention based on conserved gene upregulation from preinvasive to malignant lesions
    Elizabeth K Broussard
    Tumor Vaccine Group, Center for Translational Medicine in Women s Health, University of Washington, Seattle, WA 98109, USA
    Cancer Prev Res (Phila) 6:666-74. 2013
    ..Silencing the most highly upregulated genes, CDH3, CLDN1, KRT23, and MMP7, in adenoma and CRC cell lines resulted in a significant decrease in viability (P < 0...
  26. ncbi Keratin 5 knockout mice reveal plasticity of keratin expression in the corneal epithelium
    Hong Lu
    Institut fur Physiologische Chemie, Abteilung für Zellbiochemie, Bonner Forum Biomedizin and LIMES, Rheinische Friedrich Wilhelms Universitat, Nussallee 11, D 53115 Bonn, Germany
    Eur J Cell Biol 85:803-11. 2006
    ..a combination of antibodies and RT-PCR, we identified additional keratins expressed in the mouse cornea including K23 which was previously thought to be specific for pancreatic carcinomas...
  27. pmc K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase
    Keyna Kobza
    Department of Nutrition and Health Sciences, University of Nebraska Lincoln, Lincoln, NE 68583 0806, USA
    FEBS J 272:4249-59. 2005
    ..These studies provided evidence that K4, K9 and K18 in histone H3 are good targets for biotinylation; K14 and K23 are relatively poor targets. Antibodies were generated to histone H3, biotinylated either at K4, K9 or K18...
  28. pmc Structural insights for activation of retinal guanylate cyclase by GCAP1
    Sunghyuk Lim
    Department of Chemistry, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e81822. 2013
    ..A few GCAP1 residues in EF-hand 1 (K23, T27, G32) also show large chemical shift differences, and two of the mutations (K23D and G32N) each decrease the ..
  29. ncbi Divergent structures of carbazole degradative car operons isolated from gram-negative bacteria
    Kengo Inoue
    Biotechnology Research Center, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biosci Biotechnol Biochem 68:1467-80. 2004
    ..Sequencing analysis showed that two car operons and the neighboring regions of Pseudomonas sp. strain K23 are nearly identical to that of strain CA10...
  30. ncbi Development of degenerate and specific PCR primers for the detection and isolation of known and putative chloroethene reductive dehalogenase genes
    Christophe Regeard
    Laboratory for Environmental Biotechnology, Swiss Federal Institute of Technology Lausanne EPFL, ENAC ISTE, Bâtiment CH B Ecublens, 1015 Lausanne, Switzerland
    J Microbiol Methods 56:107-18. 2004
    ..the degenerate primers to genomic DNA of Sulfurospirillum multivorans strain K, Dehalobacter restrictus strain PER-K23, and Desulfitobacterium sp...
  31. pmc Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells
    Karin Birkenkamp-Demtroder
    Department of Molecular Medicine MOMA, Aarhus University Hospital, Skejby, Aarhus N, Denmark
    PLoS ONE 8:e73593. 2013
    Keratin 23 (KRT23) is strongly expressed in colon adenocarcinomas but absent in normal colon mucosa...
  32. pmc The restricted metabolism of the obligate organohalide respiring bacterium Dehalobacter restrictus: lessons from tiered functional genomics
    Aamani Rupakula
    Ecole Polytechnique Federale de Lausanne EPFL, School of Architecture, Civil and Environmental Engineering, Laboratory for Environmental Biotechnology, Station 6, 1015 Lausanne, Switzerland
    Philos Trans R Soc Lond B Biol Sci 368:20120325. 2013
    Dehalobacter restrictus strain PER-K23 is an obligate organohalide respiring bacterium, which displays extremely narrow metabolic capabilities...
  33. pmc Quantitating the specificity and selectivity of Gcn5-mediated acetylation of histone H3
    Yin Ming Kuo
    Department of Cancer Biology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    PLoS ONE 8:e54896. 2013
    ..In doing so, we measured Gcn5-mediated acetylation at six residues (K14>K9 ≈ K23> K18> K27 ≈ K36) and the catalytic efficiency (k(cat)/K(m)) for K9, K14, K18, and K23 as well as the ..
  34. doi The innate reactivity of a membrane associated peptide towards lipids: acyl transfer to melittin without enzyme catalysis
    Robert H Dods
    Department of Chemistry, Biophysical Sciences Institute, Durham University, Durham, United Kingdom
    Org Biomol Chem 10:5371-8. 2012
    ..The order of reactivity for amino groups on the peptide was N-terminus > K23 ≫ K21 > K7...
  35. ncbi Evidence for nonhydrogen bonded compound II in cyclic reaction of hemoglobin I from Lucina pectinata with hydrogen peroxide
    Walleska De Jesus-Bonilla
    Chemistry Department, University of Puerto Rico, Mayaguez Campus, P O Box 9019, Mayaguez, Puerto Rico 00681 9019, USA
    Biopolymers 67:178-85. 2002
    ..The rate constants ratio (k23/k41) between the formation of compound II from compound I (k23) and the oxidation of the ferrous HbI (k41, i.e...
  36. doi Targeted proteomics for quantification of histone acetylation in Alzheimer's disease
    Kangling Zhang
    Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Proteomics 12:1261-8. 2012
    ..reliably quantify specific histone acetylations in both AD and control brain by identifying the patterns of H3 K18/K23 acetylations Results of targeted proteomics assays have been validated by Western blot (WB) analysis...
  37. doi Selenocompounds in juvenile white sturgeon: estimating absorption, disposition, and elimination of selenium using Bayesian hierarchical modeling
    Susie Shih Yin Huang
    Department of Animal Science, University of California, Davis, CA 95616, USA
    Aquat Toxicol 109:150-7. 2012
    ..the fractional rates [1/h] of absorption, tissue disposition, tissue release, and urinary elimination (k12, k23, k32, and k20), the proportion of the absorbed dose eliminated through the urine (f20), and the distribution blood ..
  38. doi Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A
    Veronica Y Lang
    Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
    Pharmacogenet Genomics 22:206-14. 2012
    ..Our previous studies showed that KATP channel inhibition by the A-site sulfonylurea gliclazide was increased in the K23/A1369 haplotype...
  39. doi Coordination of Cu(2+)and Ni(2+) with the histone model peptide of H2B N-terminal tail (1-31 residues): A spectroscopic study
    Ana Mónica Nunes
    University of Ioannina, Department of Chemistry, 45110, Ioannina, Greece
    Dalton Trans 39:4369-81. 2010
    ..spectroscopy supported by CD spectroscopy indicated that Ni(2+) coordination takes place most likely through Q22-K23-K24-D25 peptide fragment...
  40. pmc The ATP-sensitive K(+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity
    Mohammad Fatehi
    Alberta Diabetes Institute, Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada
    Diabetes 61:241-9. 2012
    ..human K(ATP) channels or glutathione S-transferase and NBD2 fusion proteins containing the E23/S1369 (nonrisk) or K23/A1369 (risk) variant haplotypes...
  41. pmc Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy-related genes in type 2 diabetes
    Anil Bhanudas Gaikwad
    Department of Nephrology, Medizinische Poliklinik, University of Munich, Munchen, Germany
    Am J Pathol 176:1079-83. 2010
    ..mice with glomerulosclerosis, albuminuria, and reduced glomerular filtration rate revealed increased acetylation (K23 and 9), phosphorylation (Ser 10), dimethylation (K4), and reduced dimethylation of (K9) of cardiac histone H3 as ..
  42. doi Synthesis, biological activity, and hologram quantitative structure-activity relationships of novel allatostatin analogues
    Zhen peng Kai
    Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, People s Republic of China
    J Agric Food Chem 58:2652-8. 2010
    ..Their bioactivities in vitro were determined, and the results showed that eight analogues (K14, K15, K17, K18, K19, K23, K24, and K25) were more active than the lead, core region pentapeptide...
  43. doi Sex differences in attainment of independent funding by career development awardees
    Reshma Jagsi
    University of Michigan and Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan, USA
    Ann Intern Med 151:804-11. 2009
    ..Concerns have been raised about the career pipeline in academic medicine, including whether women with a demonstrated commitment to research succeed at the same rate as male colleagues...
  44. doi Synchronous behaviors of CBP and acetylations of lysine 18 and lysine 23 on histone H3 during porcine oocyte first meiotic division
    Kai Xue
    State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, PR China
    Mol Reprod Dev 77:605-14. 2010
    ..domains is temporally coincident with the establishments of acetylated lysine 18 (AcH3/K18), lysine 23 (AcH3/K23) and dimethylated arginine 17 (dime-H3/R17) of histone H3 at meiotic stages from germinal vesicle breakdown (GVBD) ..
  45. doi Biochemical characterization of the novel rice kinesin K23 and its kinetic study using fluorescence resonance energy transfer between an intrinsic tryptophan residue and a fluorescent ATP analogue
    Nozomi Umezu
    Division of Bioengineering, Graduate School of Engineering, Soka University, Hachioji, Tokyo 192 8577, Japan
    J Biochem 149:539-50. 2011
    ..In this study, we focused on a novel rice plant kinesin, K23, which also belongs to the kinesin-7 subfamily...
  46. doi Characterization of a novel porcine enterovirus in domestic pig in Hungary
    Akos Boros
    Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ANTSZ Regional Institute of State Public Health Service, Pecs, Hungary
    Infect Genet Evol 11:1096-102. 2011
    ..PEV was not detected in serum samples. Sequence- and phylogenetic analysis of the complete genome of swine/K23/2008/HUN (HQ702854) show relationship to PEV strains but it is separated from the PEV9 and 10, especially in ..
  47. doi Insight into mechanism of small molecule inhibitors of the MDM2-p53 interaction: molecular dynamics simulation and free energy analysis
    Jianzhong Chen
    Laboratory of Molecular Modeling and Design, State Kay Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Science, 116011 China
    J Mol Graph Model 30:46-53. 2011
    ..surface area (MM-GBSA) analyses were used to study the inhibitory mechanisms of four small molecule inhibitors, K23, YIN, DIZ and IMZ on the p53-MDM2 interaction...
  48. pmc Substitutions in the amino-terminal tail of neurospora histone H3 have varied effects on DNA methylation
    Keyur K Adhvaryu
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon, United States of America
    PLoS Genet 7:e1002423. 2011
    ..In contrast, mutants bearing substitutions of R2, A7, R8, S10, A15, P16, R17, K18, and K23 were viable...
  49. doi Cytokeratin-related loss of cellular integrity is not a major driving force of human intrinsic skin aging
    Kamil Oender
    Department of Dermatology, Muellner Hauptstrasse 48, A 5020 Salzburg, Austria
    Mech Ageing Dev 129:563-71. 2008
    ..Therefore, we compared the expression of the constituents of the cytoskeleton, keratins 1-23 (K1-K23) as well as junction-plakoglobin (JUP), alpha-tubulin (TUBA), and beta-actin (ACTB) in human foreskins of both ..
  50. ncbi Crosstalk between CARM1 methylation and CBP acetylation on histone H3
    Sylvain Daujat
    Wellcome Cancer Research UK Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Curr Biol 12:2090-7. 2002
    ....
  51. ncbi Compensation of type I and type II cytokeratin pools in lung cancer
    Nobuhiro Kanaji
    First Department of Internal Medicine, Kagawa University, Kagawa, Japan
    Lung Cancer 55:295-302. 2007
    ..CKs) constitute the largest family of intermediate filament proteins, and are subdivided into type I (CK9-CK23) and type II (CK1-CK8) subclasses...
  52. ncbi Mass spectrometric characterization of human histone H3: a bird's eye view
    C Eric Thomas
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Proteome Res 5:240-7. 2006
    ..K14 and K23 were major sites of acetylation. H3...
  53. ncbi A novel simultaneous modeling approach to estimate linearity of pharmacokinetic parameters, including saturation of intestinal efflux, in the rat
    J Andrew Williams
    Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Ann Arbor Laboratories, 2800 Plymouth Road, MI 48105, USA
    J Pharmacol Toxicol Methods 52:307-13. 2005
    ....
  54. ncbi GCN5: a supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes
    Hidehiko Kikuchi
    Department of Life Science, Frontier Science Research Center, Miyazaki Medical College, University of Miyazaki, 5200, Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Gene 347:83-97. 2005
    ..GCN5-deficiency led to decreased acetylation levels of K16/H2B and K9/H3, and increased those of K7/H2A, K18/H3, K23/H3, K27/H3, K8/H4 and K12/H4...
  55. ncbi The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Im Neuenheimer Feld 280, 69210 Heidelberg, Germany
    Differentiation 72:527-40. 2004
    ..In contrast, K23 and K24 appear to be epithelial keratins associated with simple/glandular or stratified, non-cornified epithelia, ..
  56. ncbi Physical mapping and putative candidate gene identification of a quantitative trait locus Ctb1 for cold tolerance at the booting stage of rice
    K Saito
    National Agricultural Research Center for Hokkaido Region, Hitsujigaoka 1, Toyohira, Sapporo, Hokkaido, Japan
    Theor Appl Genet 109:515-22. 2004
    ..indicated that Ctb1 is located in the 56-kb region covered by a bacterial artificial chromosome clone, OSJNBa0058 K23, that had been sequenced by the International Rice Genome Sequence Project...
  57. ncbi Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese
    Asami Suzuki
    General Dentistry, The Nippon Dental University Hospital at Tokyo, 2 3 16 Fujimi, Chiyoda ku, Tokyo 102 8158, Japan
    Biochem Biophys Res Commun 317:887-92. 2004
    ..with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic ..
  58. ncbi Evolution of trypsinogen activation peptides
    Jian Min Chen
    Institut National de la Sante et de la Recherche Medicale, Génétique Moléculaire et Génétique Epidémiologique, Universite de Bretagne Occidentale, Établissement Français du sang Bretagne, Brest, France
    Mol Biol Evol 20:1767-77. 2003
    ..of mammalian trypsinogens contains a highly conserved tetra-aspartate sequence (D19-D20-D21-D22) preceding the K23-I24 scissile peptide bond, which is hydrolyzed as the first step in the activation process...
  59. pmc Training future generations of mental health researchers: devising strategies for tough times
    Charles F Reynolds
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Acad Psychiatry 31:152-9. 2007
    ....
  60. ncbi Clinical research career development: the individual perspective
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, USA
    Acad Med 77:1084-8. 2002
    ..Finally, potential solutions are presented. These include a description of the National Institutes of Health K23, K24, and K30 programs and its new extramural Loan Repayment Program for clinical researchers...
  61. pmc Cathepsin B cleavage of the trypsinogen activation peptide
    Niels Teich
    Universitatsklinikum Leipzig, Medizinische Klinik und Poliklinik II, Gastroenterologie und Hepatologie, Philipp Rosenthal Str, 27 04103 Leipzig, Germany
    BMC Gastroenterol 2:16. 2002
    ..This action seems to be restricted to the K23-I24 peptide bond, which is the trypsinogen activation bond...
  62. ncbi A unique type I keratin intermediate filament gene family is abundantly expressed in the inner root sheaths of sheep and human hair follicles
    C S Bawden
    Department of Animal Science, University of Adelaide, Adelaide, South Australia
    J Invest Dermatol 116:157-66. 2001
    ..142_H_19), is likely to lie near the type I intermediate filament cytokeratin and hair keratin gene loci at 17q12-q21...
  63. pmc Type B histone acetyltransferase Hat1p participates in telomeric silencing
    T J Kelly
    The Department of Molecular and Cellular Biochemistry, Cellular and Developmental Biology Program, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cell Biol 20:7051-8. 2000
    ..However, K14 was the best at preserving silencing, followed by K23 and then K27; K9 and K18 alone were insufficient...
  64. ncbi The future of clinical research
    D Robertson
    Department of Medicine, Vanderbilt University, Nashville, Tenn, USA
    J Investig Med 48:309-11. 2000
    ..Research Enhancement Act, which most believe stimulated the National Institutes of Health to establish the K30, K23, and K24 Awards referred to by Dr. Robertson...
  65. ncbi Genomic characterization of human astrovirus type 6 Katano virus and the establishment of a rapid and effective reverse transcription-polymerase chain reaction to detect all serotypes of human astrovirus
    N Sakon
    Laboratory of Virology, Osaka Prefectural Institute of Public Health, Osaka, Japan
    J Med Virol 61:125-31. 2000
    ..1994]. The two representative strains, Katano virus K23 and K24, have been analyzed by sequencing the open reading frame 2 (ORF2) region after amplification by reverse ..
  66. pmc Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity
    A A Carmen
    Department of Biological Chemistry, UCLA School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 96:12356-61. 1999
    ..that recombinant HOS3 has a distinct specificity in vitro for histone H4 sites K5 and K8, H3 sites K14 and K23, H2A site K7, and H2B site K11...
  67. ncbi Dehalobacter restrictus gen. nov. and sp. nov., a strictly anaerobic bacterium that reductively dechlorinates tetra- and trichloroethene in an anaerobic respiration
    C Holliger
    Swiss Federal Institute for Environmental Science and Technology EAWAG, Limnological Research Center, CH 6047 Kastanienbaum, Switzerland
    Arch Microbiol 169:313-21. 1998
    ..bacterium that couples the reductive dechlorination of tetrachloroethene to growth, previously referred to as PER-K23, was obtained in pure culture and characterized...
  68. pmc K(ATP) channel polymorphism is associated with left ventricular size in hypertensive individuals: a large-scale community-based study
    Santiago Reyes
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA
    Hum Genet 123:665-7. 2008
    ..These findings implicate Kir6.2 K23 as a risk factor for adverse subclinical myocardial remodeling, and underscore the significance of cardiac K(ATP) ..
  69. pmc Toward unraveling the complexity of simple epithelial keratins in human disease
    M Bishr Omary
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Clin Invest 119:1794-805. 2009
    ..keratins (SEKs) are found primarily in single-layered simple epithelia and include keratin 7 (K7), K8, K18-K20, and K23. Genetically engineered mice that lack SEKs or overexpress mutant SEKs have helped illuminate several keratin ..
  70. pmc Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel
    Kevin S C Hamming
    Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Alberta, Canada
    Diabetes 58:2419-24. 2009
    ..Furthermore, there have been no studies of the S1369A variant or the combined effect of the two on K(ATP) channel function...
  71. doi Identification of tumor-associated antigens by using SEREX in hepatocellular carcinoma
    Kaijuan Wang
    Department of Epidemiology, Zhengzhou University, China
    Cancer Lett 281:144-50. 2009
    ..To identify biomarkers for diagnosis and prognosis of hepatocellular carcinoma (HCC)...
  72. doi Identification of a novel gene K23 over-expressed in fish cross-subfamily cloned embryos
    De Sheng Pei
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China
    Mol Biol Rep 36:1375-80. 2009
    A novel gene-K23, differentially expressed in cross-subfamily cloned embryos, was isolated by RACE-PCR technique...
  73. ncbi Energetics and kinetics of radical pairs in reaction centers from Rhodobacter sphaeroides. A femtosecond transient absorption study
    A R Holzwarth
    Max Planck Institut für Strahlenchemie, Mulheim a d Ruhr, Germany
    Biochemistry 35:11820-31. 1996
    ..48 ps)-1] than for the second step P+B-H-->P+BH- [k23 approximately equal to (2.53 ps)-1], in contrast to the pure forward model...
  74. doi Isolation and partial characterization of a bacteriocin produced by Pediococcus pentosaceus K23-2 isolated from Kimchi
    M S Shin
    Korea Bio Science Research Institute of Organic Bio Tech Co Ltd, Jincheon, Korea
    J Appl Microbiol 105:331-9. 2008
    Screening and partial characterization of a bacteriocin produced by Pediococcus pentosaceus K23-2 isolated from Kimchi, a traditional Korean fermented vegetable.
  75. pmc A population pharmacokinetic model of epidural lidocaine in geriatric patients: effects of low-dose dopamine
    Andrea Kwa
    Department of Pharmacy, Singapore General Hospital, Singapore
    Ther Drug Monit 30:379-89. 2008
    ..7% by dopamine. The mean rate constant for drug movement from central to peripheral compartment (K23) was increased by 47% in the patients receiving dopamine...
  76. doi Spectroscopic and kinetic study of the gas-phase CH3I-Cl and C2H5I-Cl adducts
    V Dookwah-Roberts
    School of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Phys Chem A 112:9535-43. 2008
    ..for CH3I-Cl reactions with CH3I-Cl (k9), NO (k22), and NO2 (k24), and C2H5I-Cl reactions with C2H5I-Cl (k14), NO (k23), and NO2 (k25) were measured at 250 K...
  77. pmc KATP channel Kir6.2 E23K variant overrepresented in human heart failure is associated with impaired exercise stress response
    Santiago Reyes
    Marriott Heart Disease Research Program, Mayo Clinic, Rochester, MN 55905, USA
    Hum Genet 126:779-89. 2009
    ..Here, the frequency of the minor K23 allele of the common functional Kir6...
  78. ncbi Pathways for the anaerobic microbial debromination of polybrominated diphenyl ethers
    Kristin R Robrock
    Department of Civil and Environmental Engineering, University of California, Berkeley, California, USA
    Environ Sci Technol 42:2845-52. 2008
    ..consortium containing multiple Dehalococcoides species, and two pure cultures, Dehalobacter restrictus PER-K23 and Desulfitobacterium hafniense PCP-1...
  79. pmc Prokaryotic BirA ligase biotinylates K4, K9, K18 and K23 in histone H3
    Keyna Kobza
    Departments of Nutrition and Health Sciences, University of Nebraska at Lincoln, Lincoln, NE, USA
    BMB Rep 41:310-5. 2008
    ..Moreover the biotinylation of histones by BirA ligase is consistent with the proposed role of human HCS in chromatin...
  80. doi Twentieth anniversary of American Vascular Association/Lifeline Foundation: a celebration
    William H Pearce
    Division of Vascular Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Vasc Surg 47:1351-5. 2008
    ..Clinical Scientist Development (K08) Awards, and three Mentored Patient-Oriented Research Career Development (K23) Awards...
  81. doi Drosophila parthenogenesis: a tool to decipher centrosomal vs acentrosomal spindle assembly pathways
    Maria Giovanna Riparbelli
    University of Siena, Department of Evolutionary Biology, Via A Moro 4, I 53100 Siena, Italy
    Exp Cell Res 314:1617-25. 2008
    Development of unfertilized eggs in the parthenogenetic strain K23-O-im of Drosophila mercatorum requires the stochastic interactions of self-assembled centrosomes with the female chromatin...
  82. pmc The Kazal motifs of RECK protein inhibit MMP-9 secretion and activity and reduce metastasis of lung cancer cells in vitro and in vivo
    Chong Keng Chang
    Institute of Biomedical Sciences, National Sun Yat Sen University, Kaohsiung, Taiwan
    J Cell Mol Med 12:2781-9. 2008
    ..which contained cysteine knot motif), 605-799 (named as K123 which contained three Kazal motifs), 676-799 (named as K23 which contained the last two Kazal motifs) and full-length RECK were produced and their anti-cancer effects were ..
  83. pmc Regulation of Cidea protein stability by the ubiquitin-mediated proteasomal degradation pathway
    Siu Chiu Chan
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    Biochem J 408:259-66. 2007
    ..Furthermore, K23 (Lys23) within the N-terminus of the Cidea was identified as the major contributor to its polyubiquitination signal ..
  84. ncbi Stable carbon isotope fractionation of chloroethenes by dehalorespiring isolates
    Patrick K H Lee
    Department of Civil and Environmental Engineering, University of California, Berkeley, California 94720, USA
    Environ Sci Technol 41:4277-85. 2007
    ..strain BAV1 as well as Sulfurospirillum multivorans and Dehalobacter restrictus strain PER-K23, isolates that do not dechlorinate past DCE, are reported...
  85. ncbi Research funding and mentoring in family medicine residencies
    Richard A Young
    John Peter Smith Family Medicine Residency Program, Fort Worth, Texas 76104, USA
    Fam Med 39:410-8. 2007
    ..This study's purpose was to measure the current status of research funding and mentoring in family medicine residencies and to ascertain what resources are needed to increase residencies' research output...

Research Grants72

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Shervin Assassi; Fiscal Year: 2014
    ..These productive mentor-mentee relationships will build the basis for the success of this K23 proposal. Environment: UTHSC-H is one of the largest systemic sclerosis centers in the nation...
  3. BRIAN JAMES MICKEY; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The proposed K23 career development award aims to train a promising candidate to become an independent investigator in neuroimaging, genetics, and mood disorders while characterizing neurobiological ..
  4. CYNTHIA T MCEVOY; Fiscal Year: 2016
    ..Success of this study is supported by strong pilot data from Dr. McEvoy's K23 showing statistically significant improvements in pulmonary function tests in infants born to smoking mothers who ..
  5. Enrico M Novelli; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr...
  6. Renée A Shellhaas; Fiscal Year: 2014
    ..With the expertise obtained through this K23 award, the PI will position herself as a clinical scientist uniquely able to pursue critical questions at the ..
  7. Cynthia D Morris; Fiscal Year: 2016
    ..Success of this study is supported by strong pilot data from Dr. McEvoy's K23 showing statistically significant improvements in pulmonary function tests in infants born to smoking mothers who ..
  8. ANGELA MEI TIN LEUNG; Fiscal Year: 2015
    ..During the K23 award period, my career development plans include participation in research-oriented seminars, presenting at ..
  9. Brian Till; Fiscal Year: 2016
    ..During the K23 career development period, he intends to address areas of deficiency in laboratory experience, regulatory ..
  10. KELLY VICTORIA LIANG; Fiscal Year: 2016
    ..Her track record suggests that mentorship and research activities from the K23 Mentored Patient-Oriented Research Career Development Award would enable her to develop a research career that will ..
  11. Katherine M Sharkey; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): This Mentored Patient-Oriented Research Career Development Award (K23) proposal outlines 5 years of training and research to equip the candidate to examine neurobehavioral and genetic aspects of mood ..
  12. NESTOR RAUL GONZALEZ; Fiscal Year: 2016
    ..He will be relieved of a significant portion of his teaching and clinical activities during the K23 award, to allow a dedication of at least 50%...
  13. Samay Jain; Fiscal Year: 2015
    ..of this program, he has completed a Masters of Science in Clinical Research and generated preliminary data for this K23 application...
  14. Gabriela Schmajuk; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr...
  15. Jessica B Kendrick; Fiscal Year: 2015
    ..Dr. Kendrick will have 75-85% protected time to devote to the proposed research activities of the K23 award...
  16. Ann E Tilley; Fiscal Year: 2014
    ..I am seeking the K23 award to gain the mentored, practical experience that I need to attain my long-term goal of being an independent ..
  17. Wei Ding; Fiscal Year: 2015
    ..Both have a track record of developing junior faculties to independent investigators. With the assistance of this K23 award, Dr...
  18. Lipika Samal; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): This is an application for a K23 Career Development Award for Dr. Lipika Samal, a general internist at Brigham and Women's Hospital (BWH) in Boston, Massachusetts. Dr...
  19. Kelly A Birdwell; Fiscal Year: 2015
    Project Summary/Abstract The purpose of the K23 application is to develop myself into a successful independent investigator conducting patient-oriented research in transplant pharmacogenomics...
  20. HEATHER HERSON BURRIS; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): This application for a K23 Mentored Patient-Oriented Research Career Development Award includes a 5-year plan for training and research activities that will provide the skills and experience needed ..
  21. Shonni J Silverberg; Fiscal Year: 2016
    ..Of those I have mentored, 3 currently hold and 1 recently completed NIH K23 Awards, 3 completed Masters in POR (2 under my mentorship) and 2 received Endocrine Fellows Foundations grants...
  22. Julie Paik; Fiscal Year: 2016
    ..This K23 proposal will investigate novel modifiable risk factors for VF and explore the potential role of non- invasive ..
  23. JASON PERRY BLOCK; Fiscal Year: 2016
    ..This K23 Research Career Development Award will build upon his strong methodological skills obtained during a recently-..
  24. Gregory Chang; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The goal of this K23 Mentored Patient-Oriented Research Career Development Award proposal is to provide Gregory Chang, M.D...
  25. ROBERT SCHONBERGER; Fiscal Year: 2016
    ..S. Veterans Administration. Research: This K23 Mentored Patient-Oriented Research Career Development Award proposes a series of three studies to establish the ..
  26. Peter C Chien; Fiscal Year: 2015
    ..The K23 mechanism is appropriate for this goal and also in a mentored environment serves to aid the transition of the PI&..
  27. MONIQUE EVANGELINE HINCHCLIFF; Fiscal Year: 2015
    ..Hinchcliff's goals for career development: 1) a strong K23 mentorship committee composed of three NIH-funded investigators (Drs. Rowland W...
  28. JOSEPH ABIODUN LADAPO; Fiscal Year: 2016
    ..The NHLBI K23 Mentored Patient-Oriented Research Career Development Award will provide me with the additional training I need to ..
  29. The Role of Lung Volumes in Nocturnal Asthma
    ROBERT LLEWELLYN OWENS; Fiscal Year: 2013
    ..A mentored K23 grant will provide the support necessary to pursue the ongoing training and research...
  30. Jennifer Jao; Fiscal Year: 2016
    ..their support through clinic staff and faculty who have collaborated successfully on the pilot project of this K23 Award...
  31. Corinne Keet; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): This K23 award will provide Corinne Keet, MD, MS, with the necessary training and experience to become an independent investigator performing patient-oriented research in the field of allergy and ..
  32. JASON J HASSENSTAB; Fiscal Year: 2016
    ..provided by applicant): This is an application for a Mentored Patient-Oriented Career Development Award (K23)...
  33. NICOLE LENORE MIHALOPOULOS; Fiscal Year: 2014
    ..This K23 award investigates why some obese children, adolescents and adults exhibit evidence of metabolic dysfunction (..
  34. The Ethics of Fragile X Genetic Screening and Testing Across the Lifespan
    Kruti Acharya; Fiscal Year: 2012
    ..The career development plans outlined in this K23 application will enhance the training and experience I have had to date and will provide additional guidance and ..
  35. Jay C Fournier; Fiscal Year: 2016
    ..DESCRIPTION (provided by applicant): The aim of this proposed Mentored Patient-Oriented Research Career Development (K23) Award is to provide the candidate with the training in affective neuroscience necessary to examine the functional ..
  36. Randy Patrick Auerbach; Fiscal Year: 2016
    ..Throughout the five-year K23 Mentor Patient-Oriented Research Career Development Award, the applicant will pursue an innovative line of research ..
  37. BETH YVONNE BESECKER; Fiscal Year: 2016
    ..Support from a K23 Mentored Career Development Award would provide the foundation to attain these goals. Career Development: Dr...
  38. Alexis A Topjian; Fiscal Year: 2016
    ..CHOP), is resubmitting her application for the Mentored Patient-Oriented Research Career Development Award (K23)...
  39. ANNE MARIE M SINGH; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. Anne Marie Singh, a pediatric allergist-immunologist at Northwestern Feinberg School of Medicine. Dr...
  40. NATALIE DARA SHAW; Fiscal Year: 2015
    ..Under a K23, I will gain the additional training in clinical research and sleep medicine that I need to attain my ultimate ..
  41. Andrew M Busch; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): This K23 career development award will help the PI achieve his long-term career goal to become an independent clinical investigator developing innovative treatments to address health behavior change (..
  42. Ellen A Lipstein; Fiscal Year: 2016
    ..The proposed K23 career development plan will build upon her fellowship training and early career development to focus on three ..
  43. Chamindi Seneviratne; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The scientific goal of the K23 application is to develop a novel genomic biomarker combination (Serotonin transporter gene (SERT) mRNA expression levels in 5'-HTTLPR-LL genotype carriers) for ..
  44. Erika Litvin Bloom; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The goal of this K23 Mentored Patient-Oriented Research Career Development Award is to provide the candidate, Dr...
  45. Rachel Saunders-Pullman; Fiscal Year: 2015
    ..This research builds on studies conducted during my K23 and capitalizes on two current studies funded by the Fox Foundation, the Consortium study of PD in Ashkenazi Jews (..
  46. Kimberly Driscoll; Fiscal Year: 2015
    ..This K23 study is significant because it addresses the critical need for improving insulin pump adherence where non-..
  47. BENJAMIN FRANKLIN CHONG; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The NIH K23 mentored award provides the necessary foundation for me to fulfill my career goals of being an independently-funded clinical investigator focusing on the gene and immunologic profiles of ..
  48. REBECCA ASHARE; Fiscal Year: 2016
    ..The K23 mechanism will enable me to focus at least 90% of my time and effort to develop a career as an independent clinical ..
  49. The Overlap Syndrome of COPD and OSA: Determinants of Health Status and Outcomes
    Theodore A Omachi; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. Theodore Omachi, a pulmonologist at the University of California, San Francisco (UCSF). Dr...
  50. James J Chen; Fiscal Year: 2016
    Abstract This is an application for a K23 Mentored Research Career Development Award for Dr. James Chen, an Assistant Professor and Orthodontist at UCSF. Dr...
  51. Motivational Interviewing and Physical Activity Behavior Change in Arthritis
    Linda Ehrlich-Jones; Fiscal Year: 2012
    ..The objectives of this K23 award application are 1) to increase my theoretical knowledge in behavior change, 2) to increase my methodological ..
  52. Heathy Bodies, Healthy Minds: Helping Adolescents with PCOS
    Dana L Rofey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This Mentored Patient-Oriented Research Career Development Award (K23) will enable Dr...
  53. John Koethe; Fiscal Year: 2016
    ..He is applyin for a K23 career development award to achieve his short-term goal of acquiring expertise in immunology and laboratory ..
  54. JAMES JOSEPH PRISCIANDARO; Fiscal Year: 2016
    ..Dr. Prisciandaro seeks a Mentored Patient-Oriented Research Career Development Award (K23), through the National Institutes of Health-National Institute on Alcohol Abuse and Alcoholism (NIH/NIAAA), to ..
  55. Bret R Rutherford; Fiscal Year: 2014
    Project Summary/Abstract This Mentored Patient-Oriented Research Career Development Award (K23) application describes a five year training and research program that supports the candidate to become an expert in the cognitive and neural ..
  56. VIRGINIA EMILY STURM; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. Virginia Sturm, a neuropsychology fellow at the University of California, San Francisco Memory and Aging Center (MAC). Dr...
  57. Gregory L Stuart; Fiscal Year: 2015
    ..mentoring at least 10 faculty mentees, including at minimum, one NIAAA-funded K01 award recipient, one NICHD-funded K23 recipient, one NIAAA-funded F-32 recipient, and 7 additional assistant or associate professors who have recently or ..
  58. Addressing Oral Health Disparities in Individuals with Mental Health Problems
    Lisa J Heaton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This proposal for a K23 Mentored Patient-Oriented Research Career Development Award will provide the candidate with five years of continuous mentored support and additional training in the ..
  59. Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage
    JEFFREY RADIN KAISER; Fiscal Year: 2012
    ..We will use our continuous physiological monitoring system developed during our K23 studies to determine cerebral autoregulatory capacity...
  60. Pharmacoepidemiology of Atypical Antipsychotic Drugs
    William V Bobo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): I am applying for a National Institute of Mental Health (NIMH) K23 Mentored Patient-Oriented Research Career Development Award to receive the training and research experience needed to become an ..
  61. Musculoskeletal Disorder in Dialysis Patients
    Sharon M Moe; Fiscal Year: 2010
    ..Moe has or is mentoring 13 individuals, 4 faculty (one with a K01, one with a pending K23, and one with an ADA career development award), 1 internal medicine housestaff (now a Nephrologist), and 8 ..
  62. Kirsten Neudoerffer Kangelaris; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. Kirsten Kangelaris, a hospitalist at the University of California, San Francisco. Dr...
  63. Aspiration Pneumonia in Children with Neurological Impairment
    Rajendu Srivastava; Fiscal Year: 2009
    ..This has led to wide variation in treatments offered to these children. The research plan of this K23 proposal consists of two studies that will compare the outcomes of these two treatments (SF or JT) for children ..
  64. Novel Type 2 Diabetes Mellitus Preventive Therapies
    Carine M Lenders; Fiscal Year: 2010
    ..Few therapies have demonstrated long term efficacy in combating obesity and risk of T2DM in youth. This K23 Award application outlines a mentored 5-year education and research plan, centered on the use of amino acids as ..
  65. NEURONAL DYSFUNCTION IN PREMENSTRUAL DYSPHORIC DISORDER
    C Epperson; Fiscal Year: 2004
    ..I have designed the K23 award to enable me to pursue a five-year comprehensive research-training plan...
  66. Situational Problem Solving in Adolescents with Type 2 Diabetes: Enhancing an RCT
    Russell Rothman; Fiscal Year: 2009
    ..Our initial research from the K23 award has examined barriers to the optimal management of adolescents with T2DM...
  67. RCR Multi-Component Mentoring Model
    ELIZABETH RIPLEY; Fiscal Year: 2009
    ..There are four K awards offered through the NIH, (K01, K08, K23, and K25) that are designed to provide mentored training for new researchers with the goal of developing them into ..
  68. Cost and Adherence in Drug Abuse Treatment
    KENNETH STOLLER; Fiscal Year: 2007
    ..by applicant): [unreadable] This is a proposal for a Mentored Patient-Oriented Research Career Development Award (K23)...
  69. Effect of temporal lobectomy on sensory deficits in TLE
    Arthur Grant; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): This application is for a Mentored Patient-Oriented RCDA (K23). The candidate is trained in clinical neurology and neurophysiology, and completed a Ph.D. thesis in basic visual neurophysiology...
  70. Dynamic ECG Predictors of Sudden Cardiac Death in Ischemia Cardiomyopathy
    Mary Carey; Fiscal Year: 2007
    ..provided by applicant): This application for a Mentored Patient-Oriented Research Career Development Award (K23) is designed to support a period of training to the candidate, a doctorally-prepared nurse who is an Assistant ..
  71. Neurophysiology of Working Memory in Bipolar Disorder
    Caleb Adler; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): This NIMH Mentored Patient-Oriented Career Development (K23) Award application is to support Dr. Caleb M. Adler's developing expertise in neuroimaging and bipolar disorder...
  72. Heart Failure and Beta-Blocker Use in Older Adults
    Ali Ahmed; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The purpose of this revised NIA K23 award application (1 K23 AG19211-01A1) is to provide the candidate, Ali Ahmed, MD, MPH, a fellowship trained geriatrician with additional training and research ..