leptin

Summary

Gene Symbol: leptin
Description: leptin
Alias: LEPD, OBS, leptin, leptin (murine obesity homolog), leptin (obesity homolog, mouse), obese protein, obese, mouse, homolog of, obesity factor
Species: human
Products:     leptin

Top Publications

  1. Bonda D, Stone J, Torres S, Siedlak S, Perry G, Kryscio R, et al. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem. 2014;128:162-72 pubmed publisher
    b>Leptin signaling has received considerable attention in the Alzheimer disease (AD) field...
  2. Mills K, Hamm L, Alper A, Miller C, Hudaihed A, Balamuthusamy S, et al. Circulating adipocytokines and chronic kidney disease. PLoS ONE. 2013;8:e76902 pubmed publisher
    ..We investigated the association of plasma leptin, resistin and adiponectin with CKD in 201 patients with CKD and 201 controls without...
  3. Schinzari F, Tesauro M, Rovella V, Di Daniele N, Mores N, Veneziani A, et al. Leptin stimulates both endothelin-1 and nitric oxide activity in lean subjects but not in patients with obesity-related metabolic syndrome. J Clin Endocrinol Metab. 2013;98:1235-41 pubmed publisher
    b>Leptin has nitric oxide (NO)-dependent vasodilator actions, but hyperleptinemia is an independent risk factor for cardiovascular disease...
  4. Dong Z, Xu X, Du L, Yang Y, Cheng H, Zhang X, et al. Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion. Carcinogenesis. 2013;34:974-83 pubmed publisher
    b>Leptin overexpression is closely correlated with gastric cancer (GC) invasion, but its exact effect and the underlying mechanism in tumorigenesis remain poorly understood...
  5. Tobi E, Lumey L, Talens R, Kremer D, Putter H, Stein A, et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet. 2009;18:4046-53 pubmed publisher
    ..017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure...
  6. Wolk R, Deb A, Caplice N, Somers V. Leptin receptor and functional effects of leptin in human endothelial progenitor cells. Atherosclerosis. 2005;183:131-9 pubmed
    ..We studied the role of an adipocyte-derived hormone, leptin, in the regulation of human EPC function. EPCs were grown from human circulating mononuclear cells...
  7. Hart Sailors M, Folsom A, Ballantyne C, Hoelscher D, Jackson A, Linda Kao W, et al. Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study. Diabetes Obes Metab. 2007;9:548-57 pubmed
    To investigate the effects of variation in the leptin [LEP (19A>G)] and melanocortin-4 receptor [MC4R (V103I)] genes on obesity-related traits in 13 405 African-American (AA) and white participants from the Atherosclerosis Risk in ..
  8. Teras L, Goodman M, Patel A, Bouzyk M, Tang W, Diver W, et al. No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2009;18:2553-7 pubmed publisher
    There is evidence that adipokines such as leptin and adiponectin may influence breast tumor development...
  9. Ducroc R, Guilmeau S, Akasbi K, Devaud H, Buyse M, Bado A. Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. Diabetes. 2005;54:348-54 pubmed
    The effect of leptin on glucose transport was studied in rat jejunal mucosa in Ussing chambers. Leptin was added in the luminal or the serosal compartment before the tissues were challenged with 1, 10, or 50 mmol/l glucose...
  10. Mattevi V, Zembrzuski V, Hutz M. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int J Obes Relat Metab Disord. 2002;26:1179-85 pubmed
    ..001). Our findings suggest that genetic variability in the leptin receptor and neuropeptide Y genes is implicated in body weight regulation, the LEPR Gln223Arg variant being ..

Detail Information

Publications62

  1. Bonda D, Stone J, Torres S, Siedlak S, Perry G, Kryscio R, et al. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem. 2014;128:162-72 pubmed publisher
    b>Leptin signaling has received considerable attention in the Alzheimer disease (AD) field...
  2. Mills K, Hamm L, Alper A, Miller C, Hudaihed A, Balamuthusamy S, et al. Circulating adipocytokines and chronic kidney disease. PLoS ONE. 2013;8:e76902 pubmed publisher
    ..We investigated the association of plasma leptin, resistin and adiponectin with CKD in 201 patients with CKD and 201 controls without...
  3. Schinzari F, Tesauro M, Rovella V, Di Daniele N, Mores N, Veneziani A, et al. Leptin stimulates both endothelin-1 and nitric oxide activity in lean subjects but not in patients with obesity-related metabolic syndrome. J Clin Endocrinol Metab. 2013;98:1235-41 pubmed publisher
    b>Leptin has nitric oxide (NO)-dependent vasodilator actions, but hyperleptinemia is an independent risk factor for cardiovascular disease...
  4. Dong Z, Xu X, Du L, Yang Y, Cheng H, Zhang X, et al. Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion. Carcinogenesis. 2013;34:974-83 pubmed publisher
    b>Leptin overexpression is closely correlated with gastric cancer (GC) invasion, but its exact effect and the underlying mechanism in tumorigenesis remain poorly understood...
  5. Tobi E, Lumey L, Talens R, Kremer D, Putter H, Stein A, et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet. 2009;18:4046-53 pubmed publisher
    ..017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure...
  6. Wolk R, Deb A, Caplice N, Somers V. Leptin receptor and functional effects of leptin in human endothelial progenitor cells. Atherosclerosis. 2005;183:131-9 pubmed
    ..We studied the role of an adipocyte-derived hormone, leptin, in the regulation of human EPC function. EPCs were grown from human circulating mononuclear cells...
  7. Hart Sailors M, Folsom A, Ballantyne C, Hoelscher D, Jackson A, Linda Kao W, et al. Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study. Diabetes Obes Metab. 2007;9:548-57 pubmed
    To investigate the effects of variation in the leptin [LEP (19A>G)] and melanocortin-4 receptor [MC4R (V103I)] genes on obesity-related traits in 13 405 African-American (AA) and white participants from the Atherosclerosis Risk in ..
  8. Teras L, Goodman M, Patel A, Bouzyk M, Tang W, Diver W, et al. No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2009;18:2553-7 pubmed publisher
    There is evidence that adipokines such as leptin and adiponectin may influence breast tumor development...
  9. Ducroc R, Guilmeau S, Akasbi K, Devaud H, Buyse M, Bado A. Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. Diabetes. 2005;54:348-54 pubmed
    The effect of leptin on glucose transport was studied in rat jejunal mucosa in Ussing chambers. Leptin was added in the luminal or the serosal compartment before the tissues were challenged with 1, 10, or 50 mmol/l glucose...
  10. Mattevi V, Zembrzuski V, Hutz M. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int J Obes Relat Metab Disord. 2002;26:1179-85 pubmed
    ..001). Our findings suggest that genetic variability in the leptin receptor and neuropeptide Y genes is implicated in body weight regulation, the LEPR Gln223Arg variant being ..
  11. Coskun U, Gunel N, Toruner F, Sancak B, Onuk E, Bayram O, et al. Serum leptin, prolactin and vascular endothelial growth factor (VEGF) levels in patients with breast cancer. Neoplasma. 2003;50:41-6 pubmed
    ..VEGF is an important regulator of tumor angiogenesis. Both leptin and prolactin have also been suggested to have roles in the regulation of angiogenic process...
  12. Catalano S, Marsico S, Giordano C, Mauro L, Rizza P, Panno M, et al. Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line. J Biol Chem. 2003;278:28668-76 pubmed
    b>Leptin, a product of adipocytes, is involved in the regulation of body weight and results strongly correlated to body fat content...
  13. Yanagawa T, Taniguchi A, Fukushima M, Nakai Y, Nagasaka S, Ohgushi M, et al. Leptin, triglycerides, and interleukin 6 are independently associated with C-reactive protein in Japanese type 2 diabetic patients. Diabetes Res Clin Pract. 2007;75:2-6 pubmed
    ..glucose, and serum lipids (triglycerides, HDL cholesterol, and total cholesterol), interleukin 6 (IL-6), and leptin were measured...
  14. Zirlik S, Hauck T, Fuchs F, Neurath M, Konturek P, Harsch I. Leptin, obestatin and apelin levels in patients with obstructive sleep apnoea syndrome. Med Sci Monit. 2011;17:CR159-64 pubmed
    ..The role of leptin, obestatin and apelin still needs to be established...
  15. Wang Z, Zhuo Q, Fu P, Piao J, Tian Y, Xu J, et al. Are the associations of plasma leptin and adiponectin with type 2 diabetes independent of obesity in older Chinese adults?. Diabetes Metab Res Rev. 2010;26:109-14 pubmed publisher
    ..In this study, we assessed whether the associations of two adipocyte-derived hormones, leptin and adiponectin, with type 2 diabetes are independent of obesity in older Chinese adults...
  16. Gualillo O, Eiras S, White D, Dieguez C, Casanueva F. Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2. Mol Cell Endocrinol. 2002;190:83-9 pubmed
    ..In this report, we demonstrate for the first time, that leptin is able to induce the tyrosine phosphorylation of the SH(2) containing protein SHC...
  17. Maymó J, Pérez Pérez A, Sanchez Margalet V, Dueñas J, Calvo J, Varone C. Up-regulation of placental leptin by human chorionic gonadotropin. Endocrinology. 2009;150:304-13 pubmed publisher
    b>Leptin, the 16,000 molecular weight protein product of the obese gene, was originally considered as an adipocyte-derived signaling molecule for the central control of metabolism...
  18. Bruno A, Conus S, Schmid I, Simon H. Apoptotic pathways are inhibited by leptin receptor activation in neutrophils. J Immunol. 2005;174:8090-6 pubmed
    b>Leptin regulates food intake as well as metabolic, endocrine, and immune functions. It exerts proliferative and antiapoptotic activities in a variety of cell types, including T cells...
  19. Greco S, Sarkar S, Casadesus G, Zhu X, Smith M, Ashford J, et al. Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells. Neurosci Lett. 2009;455:191-4 pubmed publisher
    We have previously demonstrated that Leptin reduces extracellular amyloid beta (Abeta) protein both in vitro and in vivo, and intracellular tau phosphorylation in vitro...
  20. Poitou C, Lacorte J, Coupaye M, Bertrais S, Bedel J, Lafon N, et al. Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery. Obes Surg. 2005;15:11-23 pubmed
    ..b>Leptin, IL6 and adiponectin can be considered as adiposity signals...
  21. Elefteriou F, Takeda S, Ebihara K, Magre J, Patano N, Kim C, et al. Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci U S A. 2004;101:3258-63 pubmed
    b>Leptin is a powerful inhibitor of bone formation in vivo...
  22. Stein K, Vasquez Garibay E, Kratzsch J, Romero Velarde E, Jahreis G. Influence of nutritional recovery on the leptin axis in severely malnourished children. J Clin Endocrinol Metab. 2006;91:1021-6 pubmed
    b>Leptin might be more important as a starvation hormone than as a satiety signal. The role of the soluble leptin receptor (sOB-R) and its regulation in children with protein energy malnutrition (PEM) is poorly understood...
  23. Galluccio E, Piatti P, Citterio L, Lucotti P, Setola E, Cassina L, et al. Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis. Am J Physiol Endocrinol Metab. 2008;294:E978-86 pubmed publisher
    ..with the polymorphisms were characterized by hyperinsulinemia and reduced reactive hyperemia, whereas increased leptin and decreased adiponectin levels were present in subjects with restenosis in the presence of reduced minimal lumen ..