LGI1

Summary

Gene Symbol: LGI1
Description: leucine rich glioma inactivated 1
Alias: ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099, leucine-rich glioma-inactivated protein 1, epitempin-1
Species: human
Products:     LGI1

Top Publications

  1. Chernova O, Somerville R, Cowell J. A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. Oncogene. 1998;17:2873-81 pubmed
    ..We have used a positional cloning strategy to isolate a novel gene, LGI1 (Leucine-rich gene-Glioma Inactivated), which is rearranged as a result of the t(10;19)(q24;q13) balanced ..
  2. Kalachikov S, Evgrafov O, Ross B, Winawer M, Barker Cummings C, Martinelli Boneschi F, et al. Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features. Nat Genet. 2002;30:335-41 pubmed
    ..we describe identification of the causative gene in autosomal-dominant partial epilepsy with auditory features (ADPEAF, MIM 600512), a rare form of idiopathic lateral temporal lobe epilepsy characterized by partial seizures with ..
  3. Chabrol E, Popescu C, Gourfinkel An I, Trouillard O, Depienne C, Senechal K, et al. Two novel epilepsy-linked mutations leading to a loss of function of LGI1. Arch Neurol. 2007;64:217-22 pubmed
    Mutations in the leucine-rich, glioma-inactivated 1 (LGI1) gene have been implicated in autosomal dominant lateral temporal epilepsy...
  4. Scheel H, Tomiuk S, Hofmann K. A common protein interaction domain links two recently identified epilepsy genes. Hum Mol Genet. 2002;11:1757-62 pubmed
    ..epilepsy, and the LGI1 gene, which is mutated in autosomal dominant partial epilepsy with auditory features (ADPEAF)...
  5. Fukata Y, Adesnik H, Iwanaga T, Bredt D, Nicoll R, Fukata M. Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science. 2006;313:1792-5 pubmed
    ..However, one form of epilepsy, autosomal dominant partial epilepsy with auditory features (ADPEAF), is characterized by mutations in a secreted neuronal protein, LGI1...
  6. Kunapuli P, Kasyapa C, Hawthorn L, Cowell J. LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway. J Biol Chem. 2004;279:23151-7 pubmed
    ..Progressive loss of LGI1 expression has been associated with the development of high grade gliomas...
  7. Owuor K, Harel N, Englot D, Hisama F, Blumenfeld H, Strittmatter S. LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology. Mol Cell Neurosci. 2009;42:448-57 pubmed publisher
    ..ADAM11, nor some forms of ADAM22, contain PDZ-interacting sequences, suggesting PSD-95-independent mechanisms in ADPEAF. Because ADAMs modulate integrins, we examined LGI1 effect on neurite outgrowth...
  8. Staub E, Perez Tur J, Siebert R, Nobile C, Moschonas N, Deloukas P, et al. The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders. Trends Biochem Sci. 2002;27:441-4 pubmed
    Recent studies suggest that mutations in the LGI1/Epitempin gene cause autosomal dominant lateral temporal epilepsy. This gene encodes a protein of unknown function, which we postulate is secreted...
  9. Sirerol Piquer M, Ayerdi Izquierdo A, Morante Redolat J, Herranz Pérez V, Favell K, Barker P, et al. The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface. Hum Mol Genet. 2006;15:3436-45 pubmed
    ..b>ADLTE-related mutants of the long form are defective for secretion and are retained in the endoplasmic reticulum and ..
  10. Morante Redolat J, Gorostidi Pagola A, Piquer Sirerol S, Saenz A, Poza J, Galán J, et al. Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. Hum Mol Genet. 2002;11:1119-28 pubmed
    ..Here we show that mutations in the LGI1 gene segregate with EPT in two families affected by this disorder...

Detail Information

Publications62

  1. Chernova O, Somerville R, Cowell J. A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. Oncogene. 1998;17:2873-81 pubmed
    ..We have used a positional cloning strategy to isolate a novel gene, LGI1 (Leucine-rich gene-Glioma Inactivated), which is rearranged as a result of the t(10;19)(q24;q13) balanced ..
  2. Kalachikov S, Evgrafov O, Ross B, Winawer M, Barker Cummings C, Martinelli Boneschi F, et al. Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features. Nat Genet. 2002;30:335-41 pubmed
    ..we describe identification of the causative gene in autosomal-dominant partial epilepsy with auditory features (ADPEAF, MIM 600512), a rare form of idiopathic lateral temporal lobe epilepsy characterized by partial seizures with ..
  3. Chabrol E, Popescu C, Gourfinkel An I, Trouillard O, Depienne C, Senechal K, et al. Two novel epilepsy-linked mutations leading to a loss of function of LGI1. Arch Neurol. 2007;64:217-22 pubmed
    Mutations in the leucine-rich, glioma-inactivated 1 (LGI1) gene have been implicated in autosomal dominant lateral temporal epilepsy...
  4. Scheel H, Tomiuk S, Hofmann K. A common protein interaction domain links two recently identified epilepsy genes. Hum Mol Genet. 2002;11:1757-62 pubmed
    ..epilepsy, and the LGI1 gene, which is mutated in autosomal dominant partial epilepsy with auditory features (ADPEAF)...
  5. Fukata Y, Adesnik H, Iwanaga T, Bredt D, Nicoll R, Fukata M. Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science. 2006;313:1792-5 pubmed
    ..However, one form of epilepsy, autosomal dominant partial epilepsy with auditory features (ADPEAF), is characterized by mutations in a secreted neuronal protein, LGI1...
  6. Kunapuli P, Kasyapa C, Hawthorn L, Cowell J. LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway. J Biol Chem. 2004;279:23151-7 pubmed
    ..Progressive loss of LGI1 expression has been associated with the development of high grade gliomas...
  7. Owuor K, Harel N, Englot D, Hisama F, Blumenfeld H, Strittmatter S. LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology. Mol Cell Neurosci. 2009;42:448-57 pubmed publisher
    ..ADAM11, nor some forms of ADAM22, contain PDZ-interacting sequences, suggesting PSD-95-independent mechanisms in ADPEAF. Because ADAMs modulate integrins, we examined LGI1 effect on neurite outgrowth...
  8. Staub E, Perez Tur J, Siebert R, Nobile C, Moschonas N, Deloukas P, et al. The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders. Trends Biochem Sci. 2002;27:441-4 pubmed
    Recent studies suggest that mutations in the LGI1/Epitempin gene cause autosomal dominant lateral temporal epilepsy. This gene encodes a protein of unknown function, which we postulate is secreted...
  9. Sirerol Piquer M, Ayerdi Izquierdo A, Morante Redolat J, Herranz Pérez V, Favell K, Barker P, et al. The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface. Hum Mol Genet. 2006;15:3436-45 pubmed
    ..b>ADLTE-related mutants of the long form are defective for secretion and are retained in the endoplasmic reticulum and ..
  10. Morante Redolat J, Gorostidi Pagola A, Piquer Sirerol S, Saenz A, Poza J, Galán J, et al. Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. Hum Mol Genet. 2002;11:1119-28 pubmed
    ..Here we show that mutations in the LGI1 gene segregate with EPT in two families affected by this disorder...
  11. Nobile C, Michelucci R, Andreazza S, Pasini E, Tosatto S, Striano P. LGI1 mutations in autosomal dominant and sporadic lateral temporal epilepsy. Hum Mutat. 2009;30:530-6 pubmed publisher
    Autosomal dominant lateral temporal epilepsy (ADLTE) or autosomal dominant partial epilepsy with auditory features (ADPEAF) is an inherited epileptic syndrome with onset in childhood/adolescence and benign evolution...
  12. Ottman R, Risch N, Hauser W, Pedley T, Lee J, Barker Cummings C, et al. Localization of a gene for partial epilepsy to chromosome 10q. Nat Genet. 1995;10:56-60 pubmed
    ..83 at theta = 0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval. ..
  13. Berkovic S, Izzillo P, McMahon J, Harkin L, McIntosh A, Phillips H, et al. LGI1 mutations in temporal lobe epilepsies. Neurology. 2004;62:1115-9 pubmed
    ..have been found in a few families with the syndrome of autosomal dominant partial epilepsy with auditory features (ADPEAF)...
  14. Kunapuli P, Chitta K, Cowell J. Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene. Oncogene. 2003;22:3985-91 pubmed
    The leucine-rich, glioma-inactivated (LGI1) gene, located in 10q24, was originally identified because it was interrupted and inactivated by a reciprocal chromosome translocation in the T98G glioma cell line...
  15. Ottman R, Winawer M, Kalachikov S, Barker Cummings C, Gilliam T, Pedley T, et al. LGI1 mutations in autosomal dominant partial epilepsy with auditory features. Neurology. 2004;62:1120-6 pubmed
    S: Mutations in LGI1 cause autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of familial temporal lobe epilepsy with auditory ictal manifestations...
  16. Striano P, de Falco A, Diani E, Bovo G, Furlan S, Vitiello L, et al. A novel loss-of-function LGI1 mutation linked to autosomal dominant lateral temporal epilepsy. Arch Neurol. 2008;65:939-42 pubmed publisher
    ..for autosomal dominant lateral temporal epilepsy have been found in the leucine-rich, glioma-inactivated 1 (LGI1) gene...
  17. Gu W, Brodtkorb E, Steinlein O. LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures. Ann Neurol. 2002;52:364-7 pubmed
    ..lateral temporal lobe epilepsy previously has been linked to chromosome 10q22-q24, and recently mutations in the LGI1 gene (Leucine-rich gene, Glioma Inactivated) have been found in some autosomal dominant lateral temporal lobe ..
  18. Gass M, Larson J, Cochrane B, Manson J, Lane D, Barnabei V, et al. Sexual activity and vaginal symptoms in the postintervention phase of the Women's Health Initiative Hormone Therapy Trials. Menopause. 2017;: pubmed publisher
    ..of discontinuing oral hormone therapy (HT) on sexual activity, vaginal symptoms, and sexual activity components among participants in the estrogen-progestin therapy (EPT) and estrogen therapy (ET) trial of the Women's Health Initiative.
  19. Smith S, Xu L, Kasten M, Anderson M. Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels. J Neurochem. 2012;120:611-21 pubmed publisher
    ..Importantly, leucine-rich glioma-inactivated-1 (LGI1), a secreted synaptic protein mutated to cause human partial epilepsy, regulated this seizure-induced circuit ..
  20. Okah E, Arya V, Rogers M, Kim M, Schillinger J. Sentinel Surveillance for Expedited Partner Therapy Prescriptions Using Pharmacy Data, in 2 New York City Neighborhoods, 2015. Sex Transm Dis. 2017;44:104-108 pubmed publisher
    Expedited partner therapy (EPT) for Chlamydia trachomatis (Ct) is the practice of providing Ct-infected patients with medication, or prescription (prescription-EPT) to deliver to their sex partners without first examining those partners...
  21. Luo K, Hu X, He Q, Wu Z, Cheng H, Hu Z, et al. Impacts of rapid urbanization on the water quality and macroinvertebrate communities of streams: A case study in Liangjiang New Area, China. Sci Total Environ. 2017;: pubmed publisher
    ..The sensitive species (e.g., EPT taxa) were mainly centralized at LUL sites, whereas tolerant species, such as Tubificidae (17.3%), Chironomidae (12...
  22. Tan G, Kondo T, Murakami N, Imamura K, Enami T, Tsukita K, et al. Induced pluripotent stem cells derived from an autosomal dominant lateral temporal epilepsy (ADLTE) patient carrying S473L mutation in leucine-rich glioma inactivated 1 (LGI1). Stem Cell Res. 2017;24:12-15 pubmed publisher
    Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited epileptic syndrome, and it is associated with mutations of leucine-rich glioma inactivated 1 (LGI1) gene...
  23. Yuzaki M. Two Classes of Secreted Synaptic Organizers in the Central Nervous System. Annu Rev Physiol. 2017;: pubmed publisher
    ..These include Lgi1, Cbln1, neuronal pentraxins, Hevin, thrombospondins, and glypicans...
  24. Manna I, Mumoli L, Labate A, Citrigno L, Ferlazzo E, Aguglia U, et al. Autosomal dominant lateral temporal epilepsy (ADLTE): absence of chromosomal rearrangements in LGI1 gene. Epilepsy Res. 2014;108:597-9 pubmed publisher
    ..1 (LGI1) gene are found in about half of the families with autosomal dominant lateral temporal epilepsy (ADLTE)...
  25. Di Bonaventura C, Operto F, Busolin G, Egeo G, D Aniello A, Vitello L, et al. Low penetrance and effect on protein secretion of LGI1 mutations causing autosomal dominant lateral temporal epilepsy. Epilepsia. 2011;52:1258-64 pubmed publisher
    ..DNAs from family members were screened for LGI1 mutations. The effects of mutations on Lgi1 protein secretion were determined in transfected culture cells...
  26. Greene B, Vansuch G, Chica B, Adams M, Dyer R. Applications of Photogating and Time Resolved Spectroscopy to Mechanistic Studies of Hydrogenases. Acc Chem Res. 2017;50:2718-2726 pubmed publisher
    ..the pre-steady-state kinetics revealed a distinct role of proton tunneling in concerted electron-proton transfer (EPT) modulated by a conserved glutamic acid residue...
  27. Pizzuti A, Flex E, Di Bonaventura C, Dottorini T, Egeo G, Manfredi M, et al. Epilepsy with auditory features: a LGI1 gene mutation suggests a loss-of-function mechanism. Ann Neurol. 2003;53:396-9 pubmed
    Autosomal dominant partial epilepsy with auditory features (ADPEAF) is a genetically heterogeneous disorder. Some patients exhibit mutations in the leucine-rich glioma inactivated (LGI1) gene...
  28. Heiman G, Kamberakis K, Gill R, Kalachikov S, Pedley T, Hauser W, et al. Evaluation of depression risk in LGI1 mutation carriers. Epilepsia. 2010;51:1685-90 pubmed publisher
    ..partial epilepsy with auditory features caused by mutations in the leucine-rich, glioma inactivated 1 gene (LGI1)...
  29. Leonardi E, Dazzo E, Aspromonte M, Tabaro F, Pascarelli S, Tosatto S, et al. CNTNAP2 mutations and autosomal dominant epilepsy with auditory features. Epilepsy Res. 2017;139:51-53 pubmed publisher
    ..Mutations in LGI1 and RELN genes account for the disorder in about 50% of ADEAF families...
  30. Schimmel M, Frühwald M, Bien C. Limbic encephalitis with LGI1 antibodies in a 14-year-old boy. Eur J Paediatr Neurol. 2018;22:190-193 pubmed publisher
    Limbic encephalitis (LE) with antibodies against leucine-rich glioma inactivated protein 1 (LGI1) is an auto-antibody mediated disorder with characteristic symptoms as dysfunction of memory, faciobrachial dystonic seizures and ..
  31. Wang K, Li F, Chen L, Lai Y, Zhang X, Li H. Change in risk of breast cancer after receiving hormone replacement therapy by considering effect-modifiers: a systematic review and dose-response meta-analysis of prospective studies. Oncotarget. 2017;8:81109-81124 pubmed publisher
    ..02 (95% CI = 1.02-1.02). Moreover, RR for current estrogen plus progestin therapy (EPT) users was 1.76, (95% CI = 1.56-1.96), and for per year increases was 1.08 (95% CI = 1.08-1.08)...
  32. Zhu Y, Liu H, Zhang L, Zeng T, Song Y, Qin Y, et al. Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma. Carcinogenesis. 2014;35:1154-61 pubmed publisher
    Here, we report the characterization of a candidate tumor suppressor gene leucine-rich glioma inactivated 1 (LGI1) in human esophageal squamous cell carcinoma (ESCC)...
  33. van Sonderen A, Roelen D, Stoop J, Verdijk R, Haasnoot G, Thijs R, et al. Anti-LGI1 encephalitis is strongly associated with HLA-DR7 and HLA-DRB4. Ann Neurol. 2017;81:193-198 pubmed publisher
    Leucine-rich glioma-inactivated1 (LGI1) encephalitis is an antibody-associated inflammation of the limbic area. An autoimmune etiology is suspected but not yet proven...
  34. Bisulli F, Tinuper P, Scudellaro E, Naldi I, Bagattin A, Avoni P, et al. A de novo LGI1 mutation in sporadic partial epilepsy with auditory features. Ann Neurol. 2004;56:455-6 pubmed
  35. Hedera P, Abou Khalil B, Crunk A, Taylor K, Haines J, Sutcliffe J. Autosomal dominant lateral temporal epilepsy: two families with novel mutations in the LGI1 gene. Epilepsia. 2004;45:218-22 pubmed
    ..LGI1) were recently described in a small number of families with autosomal dominant lateral temporal epilepsy (ADLTE)...
  36. Klein K, Pendziwiat M, Cohen R, Appenzeller S, de Kovel C, Rosenow F, et al. Autosomal dominant epilepsy with auditory features: a new LGI1 family including a phenocopy with cortical dysplasia. J Neurol. 2016;263:11-6 pubmed publisher
    ..We performed linkage analysis and exome sequencing. LGI1, KANK1 and RELN were Sanger sequenced. Seizure semiology of 11 individuals was consistent with ADEAF...
  37. Balint B, Vincent A, Meinck H, Irani S, Bhatia K. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. Brain. 2017;: pubmed publisher
    ..spectrum disorders with GAD, glycine receptor, amphiphysin or DPPX antibodies, specific paroxysmal dystonias with LGI1 antibodies, and cerebellar ataxia with various anti-neuronal antibodies...
  38. CRANE S, Backus L, Stockman B, Carpenter J, Lin L, Haase J. Understanding Treatment Burden and Quality of Life Impact of Participating in an Early-Phase Pediatric Oncology Clinical Trial: A Pilot Study. J Pediatr Oncol Nurs. 2018;35:25-35 pubmed publisher
    ..Despite the extensive use of EPTs in pediatric oncology, little is known about parent and child experiences during EPT participation...
  39. de Bellescize J, Boutry N, Chabrol E, André Obadia N, Arzimanoglou A, LeGuern E, et al. A novel three base-pair LGI1 deletion leading to loss of function in a family with autosomal dominant lateral temporal epilepsy and migraine-like episodes. Epilepsy Res. 2009;85:118-22 pubmed publisher
    Mutations in LGI1 have been reported in several families with autosomal dominant lateral temporal epilepsy. In a family in which three patients also experienced migraine-like episodes we found a novel three base-pair deletion (c...
  40. Wan Z, Lu S, Zhao D, Ding Y, Chen P. Arginine-rich ionic complementary peptides as potential drug carriers: Impact of peptide sequence on size, shape and cell specificity. Nanomedicine. 2016;12:1479-88 pubmed publisher
    ..peptide length has a pronounced impact on the morphology of peptide complex with the anticancer drug ellipticine (EPT), and the amino acid arrangement affects the complex size...
  41. Kim T, Lee S, Moon J, Sunwoo J, Byun J, Lim J, et al. Anti-LGI1 encephalitis is associated with unique HLA subtypes. Ann Neurol. 2017;81:183-192 pubmed publisher
    Autoimmune encephalitis (AE), represented by anti-leucine-rich glioma-inactivated 1 (anti-LGI1) and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, has increasing clinical significance based on recent discoveries of neuronal ..
  42. Wennberg R, Steriade C, Chen R, Andrade D. Frontal infraslow activity marks the motor spasms of anti-LGI1 encephalitis. Clin Neurophysiol. 2018;129:59-68 pubmed publisher
    The clinical and electrographic features of seizures in anti-LGI1 encephalitis are distinct from those seen in other autoimmune encephalitides or non-encephalitic epilepsies...
  43. Di Bonaventura C, Carni M, Diani E, Fattouch J, Vaudano E, Egeo G, et al. Drug resistant ADLTE and recurrent partial status epilepticus with dysphasic features in a family with a novel LGI1mutation: electroclinical, genetic, and EEG/fMRI findings. Epilepsia. 2009;50:2481-6 pubmed publisher
    We characterized a family with autosomal dominant lateral temporal epilepsy (ADLTE) whose proband presented uncommon electroclinical findings such as drug-resistant seizures and recurrent episodes of status epilepticus with dysphasic ..
  44. Fertig E, Lincoln A, Martinuzzi A, Mattson R, Hisama F. Novel LGI1 mutation in a family with autosomal dominant partial epilepsy with auditory features. Neurology. 2003;60:1687-90 pubmed
    Autosomal dominant partial epilepsy with auditory features (ADPEAF) is a rare idiopathic epilepsy syndrome caused by mutations in the leucine-rich, glioma-inactivated 1 (LGI1) gene...
  45. Ahn S, Kim D, Park S. Efficacy of Ultrasound Doppler Flowmetry in Assessing Pulp Vitality of Traumatized Teeth: A Propensity Score Matching Analysis. J Endod. 2017;: pubmed publisher
    This retrospective study aimed to evaluate and compare the efficacy of ultrasound Doppler flowmetry (UDF) with that of electric pulp testing (EPT) in assessing pulp vitality in traumatized teeth.
  46. Ho Y, Ionita Laza I, Ottman R. Domain-dependent clustering and genotype-phenotype analysis of LGI1 mutations in ADPEAF. Neurology. 2012;78:563-8 pubmed publisher
    ..mapped to one of the gene's 2 major functional domains, N-terminal leucine-rich repeats (LRRs) and C-terminal epitempin (EPTP) repeats, and classified according to predicted effect on the encoded protein (truncation vs missense)...
  47. Mooney R, Abdul Majid A, Batalla J, Annala A, Aboody K. Cell-mediated enzyme prodrug cancer therapies. Adv Drug Deliv Rev. 2017;118:35-51 pubmed publisher
    ..Here we discuss the current pre-clinical and clinical use of cell-mediated enzyme prodrug therapy (EPT) directed against solid tumors and avenues for further development...
  48. Reid A, Rogers M, Arya V, Edelstein Z, Schillinger J. Pharmacists' Knowledge and Practices Surrounding Expedited Partner Therapy for Chlamydia trachomatis, New York City, 2012 and 2014. Sex Transm Dis. 2016;43:679-684 pubmed
    ..for a patient's partner without the partner having a medical evaluation ("prescription-expedited partner therapy" [EPT]), and use of prescription-EPT is common...
  49. Naddeo C, Vertuccio L, Barra G, Guadagno L. Nano-Charged Polypropylene Application: Realistic Perspectives for Enhancing Durability. Materials (Basel). 2017;10: pubmed publisher
    ..The extent of the IP is strictly correlated to the amount of MWCNTs. The low electrical percolation threshold (EPT) and the electrical conductivity of the nanocomposites, together with their excellent thermal and photooxidative ..
  50. Gambacciani M, Biglia N, Cagnacci A, Di Carlo C, Caruso S, Cicinelli E, et al. Menopause and hormone replacement therapy. The 2017 recommendations of the Italian Menopause Society. Minerva Ginecol. 2017;: pubmed publisher
    ..The term HRT typically includes estrogen replacement therapy (ERT) and estrogen- progestogen therapy (EPT)...
  51. Tofaris G, Irani S, Cheeran B, Baker I, Cader Z, Vincent A. Immunotherapy-responsive chorea as the presenting feature of LGI1-antibody encephalitis. Neurology. 2012;79:195-6 pubmed publisher
  52. Leonardi E, Andreazza S, Vanin S, Busolin G, Nobile C, Tosatto S. A computational model of the LGI1 protein suggests a common binding site for ADAM proteins. PLoS ONE. 2011;6:e18142 pubmed publisher
    Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome...
  53. Mikhail M, Flanders M. Clinical profiles and surgical outcomes of adult esotropia. Can J Ophthalmol. 2017;52:403-408 pubmed publisher
    ..into group 1 (35 with childhood-onset esotropia [CET]) and group 2 (38 with adult-onset esophoria-tropia [EPT])...
  54. Bastiaansen A, van Sonderen A, Titulaer M. Autoimmune encephalitis with anti-leucine-rich glioma-inactivated 1 or anti-contactin-associated protein-like 2 antibodies (formerly called voltage-gated potassium channel-complex antibodies). Curr Opin Neurol. 2017;30:302-309 pubmed publisher
    ..are not directed at the VGKC itself but to two closely associated proteins, anti-leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (Caspr2)...
  55. Chen C, Wang X, Zhang C, Cui T, Shi W, Guan H, et al. Seizure semiology in leucine-rich glioma-inactivated protein 1 antibody-associated limbic encephalitis. Epilepsy Behav. 2017;: pubmed publisher
    The objective of this study was to advance the characterization of seizure semiology in leucine-rich glioma-inactivated protein 1 (LGI1) antibody-associated limbic encephalitis (LE).
  56. Oliver A, Rogers M, Schillinger J. The Impact of Prescriptions on Sex Partner Treatment Using Expedited Partner Therapy for Chlamydia trachomatis Infection, New York City, 2014-2015. Sex Transm Dis. 2016;43:673-678 pubmed
    ..Expedited partner therapy (EPT) has been shown to prevent reinfection when provided as medication (Medication-EPT) that patients give to sex ..
  57. Rosanoff M, Ottman R. Penetrance of LGI1 mutations in autosomal dominant partial epilepsy with auditory features. Neurology. 2008;71:567-71 pubmed publisher
    ..have been identified in about 50% of families with autosomal dominant partial epilepsy with auditory features (ADPEAF), but estimates of LGI1 mutation penetrance have ranged widely, from 50 to 85%...
  58. Yu Y, Hasegawa D, Fujiwara Igarashi A, Hamamoto Y, Mizoguchi S, Kuwabara T, et al. Molecular cloning and characterization of the family of feline leucine-rich glioma-inactivated (LGI) genes, and mutational analysis in familial spontaneous epileptic cats. BMC Vet Res. 2017;13:389 pubmed publisher
    ..into generalized epileptic seizures, while cats with antibodies against voltage-gated potassium channel complexed/LGI1 show limbic encephalitis and recurrent limbic seizures...
  59. Magini P, Bisulli F, Baldassari S, Stipa C, Naldi I, Licchetta L, et al. LGI1 microdeletions are not a frequent cause of partial epilepsy with auditory features (PEAF). Epilepsy Res. 2014;108:972-7 pubmed publisher
    Heterozygous mutations of the leucine-rich, glioma-inactivated 1 gene (LGI1) are the major known cause of partial epilepsy with auditory features (PEAF), accounting for roughly 50% of families...
  60. Bovo G, Diani E, Bisulli F, Di Bonaventura C, Striano P, Gambardella A, et al. Analysis of LGI1 promoter sequence, PDYN and GABBR1 polymorphisms in sporadic and familial lateral temporal lobe epilepsy. Neurosci Lett. 2008;436:23-6 pubmed publisher
    ..coding region or exon splice sites of the leucine-rich, glioma-inactivated 1 (LGI1) gene account for about 50% of ADLTE families. De novo LGI1 mutations of the same kind have also been found in about 2...
  61. Tessa C, Michelucci R, Nobile C, Giannelli M, Della Nave R, Testoni S, et al. Structural anomaly of left lateral temporal lobe in epilepsy due to mutated LGI1. Neurology. 2007;69:1298-300 pubmed