lipoprotein lipase

Summary

Gene Symbol: lipoprotein lipase
Description: lipoprotein lipase
Alias: HDLCQ11, LIPD, lipoprotein lipase
Species: human

Top Publications

  1. ncbi Lipoprotein lipase gene mutations and the genetic susceptibility of preeclampsia
    Y J Kim
    Department of Obstetrics and Gynecology, Ewha Woman s University Y J K, Seoul, Korea
    Hypertension 38:992-6. 2001
  2. ncbi Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages
    Guosong Qiu
    Atherosclerosis Specialty Laboratory, Healthy Heart Program, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
    J Lipid Res 48:2112-22. 2007
  3. doi Presynaptic defects underlying impaired learning and memory function in lipoprotein lipase-deficient mice
    Xunde Xian
    Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, 38 Xueyuan Road, Hai Dian District, Beijing, China
    J Neurosci 29:4681-5. 2009
  4. doi HIV type 1 alters mesenchymal stem cell differentiation potential and cell phenotype ex vivo
    Eoin J Cotter
    Clinical Research Center, University College Dublin, Ireland
    AIDS Res Hum Retroviruses 27:187-99. 2011
  5. ncbi Lack of relationship in long-term type 1 diabetic patients between diabetic nephropathy and polymorphisms in apolipoprotein epsilon, lipoprotein lipase and cholesteryl ester transfer protein. Genétique de la Nephropathie Diabétique Study Group. Données Ep
    S Hadjadj
    Medecine B, University Hospital, Angers, France
    Nephrol Dial Transplant 15:1971-6. 2000
  6. ncbi Lipoprotein lipase D9N, N291S and S447X polymorphisms: their influence on premature coronary heart disease and plasma lipids
    F M van Bockxmeer
    Department of Pathology, The University of Western Australia, Perth, WA, Australia
    Atherosclerosis 157:123-9. 2001
  7. ncbi Associations of LPL and APOC3 gene polymorphisms on plasma lipids in a Mediterranean population: interaction with tobacco smoking and the APOE locus
    Dolores Corella
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain
    J Lipid Res 43:416-27. 2002
  8. ncbi Nephropathy in type 1 diabetes: a manifestation of insulin resistance and multiple genetic susceptibilities? Further evidence from the Pittsburgh Epidemiology of Diabetes Complication Study
    Trevor J Orchard
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, DLR Building, 35123 Fifth Avenue, Pittsburgh, PA 15213, USA
    Kidney Int 62:963-70. 2002
  9. ncbi Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men
    Camilla Skoglund-Andersson
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Atherosclerosis 167:311-7. 2003
  10. ncbi Combination of apolipoprotein E2 and lipoprotein lipase heterozygosity causes severe hypertriglyceridemia during pregnancy
    S Hieronimus
    Service d endocrinologie médecine de la reproduction, Hopital L Archet, Nice, France
    Diabetes Metab 31:295-7. 2005

Research Grants

  1. Anthony W Ferrante; Fiscal Year: 2016
  2. Antibodies to Define Molecular Mechanisms of Hypertriglyceridemia
    Stephen G Young; Fiscal Year: 2010
  3. LPL-Deficient Cats-A Quantitative Model of Gene Delivery
    PHILIP RICHARD VULLIET; Fiscal Year: 2010
  4. Robert H Eckel; Fiscal Year: 2014
  5. NUTRITION AND LIPOPROTEIN LIPASE-MOLECULAR MECHANISMS
    SUSAN FRIED; Fiscal Year: 1992
  6. IRA JAY GOLDBERG; Fiscal Year: 2016
  7. Nir Uriel; Fiscal Year: 2014
  8. Regulation of lipoprotein lipase in adipocytes
    Philip A Kern; Fiscal Year: 2011
  9. Jianhua Shao; Fiscal Year: 2016
  10. Ann Hwee Lee; Fiscal Year: 2015

Detail Information

Publications242 found, 100 shown here

  1. ncbi Lipoprotein lipase gene mutations and the genetic susceptibility of preeclampsia
    Y J Kim
    Department of Obstetrics and Gynecology, Ewha Woman s University Y J K, Seoul, Korea
    Hypertension 38:992-6. 2001
    ..The objective of this study was to evaluate the association between preeclampsia and mutations within the lipoprotein lipase (LPL) gene...
  2. ncbi Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages
    Guosong Qiu
    Atherosclerosis Specialty Laboratory, Healthy Heart Program, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
    J Lipid Res 48:2112-22. 2007
    ..We conclude that atorvastatin reduces LPL and EL expression by reducing the activation of LXRalpha and NF-kappaB, respectively...
  3. doi Presynaptic defects underlying impaired learning and memory function in lipoprotein lipase-deficient mice
    Xunde Xian
    Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, 38 Xueyuan Road, Hai Dian District, Beijing, China
    J Neurosci 29:4681-5. 2009
    b>Lipoprotein lipase (LPL) is predominantly expressed in adipose and muscle where it plays a crucial role in the metabolism of triglyceride-rich plasma lipoproteins...
  4. doi HIV type 1 alters mesenchymal stem cell differentiation potential and cell phenotype ex vivo
    Eoin J Cotter
    Clinical Research Center, University College Dublin, Ireland
    AIDS Res Hum Retroviruses 27:187-99. 2011
    ..These results suggest that HIV-1 directly interacts with and may infect MSCs resulting in alterations of their differentiation potential, findings that significantly enhance our understanding of HIV-1-associated bone and fat toxicities...
  5. ncbi Lack of relationship in long-term type 1 diabetic patients between diabetic nephropathy and polymorphisms in apolipoprotein epsilon, lipoprotein lipase and cholesteryl ester transfer protein. Genétique de la Nephropathie Diabétique Study Group. Données Ep
    S Hadjadj
    Medecine B, University Hospital, Angers, France
    Nephrol Dial Transplant 15:1971-6. 2000
    ..Genetic susceptibility contributes to the risk of diabetic nephropathy. Lipid disorders may favour diabetic nephropathy. Thus polymorphisms in lipid metabolism are candidates for the genetic component of risk for diabetic nephropathy...
  6. ncbi Lipoprotein lipase D9N, N291S and S447X polymorphisms: their influence on premature coronary heart disease and plasma lipids
    F M van Bockxmeer
    Department of Pathology, The University of Western Australia, Perth, WA, Australia
    Atherosclerosis 157:123-9. 2001
    b>Lipoprotein lipase (LPL) plays a pivotal role in lipoprotein metabolism...
  7. ncbi Associations of LPL and APOC3 gene polymorphisms on plasma lipids in a Mediterranean population: interaction with tobacco smoking and the APOE locus
    Dolores Corella
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain
    J Lipid Res 43:416-27. 2002
    ..Understanding this gene-gene-environmental interaction may facilitate preventive interventions to reduce coronary artery disease risk...
  8. ncbi Nephropathy in type 1 diabetes: a manifestation of insulin resistance and multiple genetic susceptibilities? Further evidence from the Pittsburgh Epidemiology of Diabetes Complication Study
    Trevor J Orchard
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, DLR Building, 35123 Fifth Avenue, Pittsburgh, PA 15213, USA
    Kidney Int 62:963-70. 2002
    ..The pathogenesis of diabetic nephropathy remains unclear, although previous reports implicate a wide range of putative genetic and metabolic factors...
  9. ncbi Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men
    Camilla Skoglund-Andersson
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Atherosclerosis 167:311-7. 2003
    ..Common variants in the cholesteryl ester transfer protein (CETP-629C/A), lipoprotein lipase (LPL S447X), hepatic lipase (HL-480C/T) and apolipoprotein E (apoE e2/e3/e4) genes were studied in relation ..
  10. ncbi Combination of apolipoprotein E2 and lipoprotein lipase heterozygosity causes severe hypertriglyceridemia during pregnancy
    S Hieronimus
    Service d endocrinologie médecine de la reproduction, Hopital L Archet, Nice, France
    Diabetes Metab 31:295-7. 2005
    ..of marked hypertriglyceridemia (HTG) is rare and may result from combination of heterozygote mutation in the lipoprotein lipase (LPL) gene and apolipoprotein E2 isoform, as reported in this case...
  11. pmc Functional significance of lipoprotein lipase HindIII polymorphism associated with the risk of coronary artery disease
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Atherosclerosis 200:102-8. 2008
    b>Lipoprotein lipase (LPL) plays a pivotal role in lipid metabolism by hydrolyzing triglyceride (TG)-rich lipoprotein particles. Abnormalities in normal LPL function are associated with the risk of coronary artery disease (CAD)...
  12. ncbi A missense mutation Pro157 Arg in lipoprotein lipase (LPLNijmegen) resulting in loss of catalytic activity
    T Bruin
    Centre for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, University of Amsterdam, The Netherlands
    Eur J Biochem 208:267-72. 1992
    Here we report on the molecular defect that leads to a deficiency of lipoprotein lipase (LPL) activity in a proband of Dutch descent. Southern-blot analysis of the LPL gene from the patient did not reveal any major DNA rearrangements...
  13. ncbi Catalytic triad residue mutation (Asp156----Gly) causing familial lipoprotein lipase deficiency. Co-inheritance with a nonsense mutation (Ser447----Ter) in a Turkish family
    F Faustinella
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 266:14418-24. 1991
    ..of Turkish descent who had normal plasma apolipoprotein C-II levels and undetectable plasma post-heparin lipoprotein lipase (LPL) activity...
  14. ncbi Human genes involved in lipolysis of plasma lipoproteins: mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to 15q21
    R S Sparkes
    Department of Medicine, School of Medicine, University of California, Los Angeles 90024
    Genomics 1:138-44. 1987
    We have used cDNA probes for lipoprotein lipase and hepatic lipase to determine the chromosomal and subchromosomal locations of the human genes for these lipolytic enzymes...
  15. ncbi Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis
    R M Fisher
    Department of Medicine, University College London Medical School, Rayne Institute, UK
    Atherosclerosis 135:145-59. 1997
    The importance of the enzyme lipoprotein lipase (LPL) in the development of dyslipidaemia and atherosclerosis is increasingly recognised...
  16. ncbi Common genetic variants of lipoprotein lipase and apolipoproteins AI-CIII that relate to coronary artery disease: a study in Chinese and European subjects
    Q Zhang
    Department of Metabolism and Genetics, St Bartholomew s Hospital, London, EC1A 7BE, United Kingdom
    Mol Genet Metab 64:177-83. 1998
    ..The loci studied include lipoprotein lipase (Asp9Asn, Asn291Ser, Ser447Ter, and Thr361Thr); apolipoprotein A1 (restriction sites at MspI, XmnI, and PstI)..
  17. ncbi Polymorphism of the lipoprotein lipase gene and risk of atherothrombotic cerebral infarction in the Japanese
    Y Shimo-Nakanishi
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Stroke 32:1481-6. 2001
    ..b>Lipoprotein lipase (LPL) plays an important role in plasma lipoprotein metabolism...
  18. ncbi Lipoprotein lipase affects the survival and differentiation of neural cells exposed to very low density lipoprotein
    Eric Paradis
    Department of Medical Biology, Faculty of Medicine and Lipid Research Centre, Laval University Medical Research Centre, Laval University, Ste Foy, Quebec G1K 7P4, Canada
    J Biol Chem 278:9698-705. 2003
    b>Lipoprotein lipase (LPL) is a key enzyme involved in the metabolism of lipoproteins, providing tissues like adipose tissue or skeletal muscle with fatty acids. LPL is also expressed in the brain, fulfilling yet unknown functions...
  19. ncbi Variation near the region of the lipoprotein lipase gene and hypertension or blood pressure levels in Chinese
    Wenjie Yang
    Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P R China
    Hypertens Res 26:459-64. 2003
    Essential hypertension (EH) is a common late-onset disease that exhibits complex genetic heterogeneity. Human lipoprotein lipase (LPL) is a rate-limiting enzyme that regulates the catabolism of triglycerides (TG) and chylomicrons (CM)...
  20. ncbi The 3' untranslated region of the lipoprotein lipase gene: haplotype structure and association with post-heparin plasma lipase activity
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Becker B 128, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 90:4816-23. 2005
    Haplotypes comprising six single nucleotide polymorphisms (SNPs) (intron 7 to intron 9) of the lipoprotein lipase (LPL) gene appear to influence risk for atherosclerosis and insulin resistance in Mexican-Americans.
  21. ncbi Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia
    Despoina M Choumerianou
    Laboratory of Molecular Biology, Department of Science of Dietetics Nutrition, Harokopio University of Athens, Athens, Greece
    Clin Chem Lab Med 44:799-806. 2006
    ..The clinical expression of FH is highly variable, even in patients carrying the same LDL receptor (LDLR) gene mutation. This variability may be due to environmental and other genetic factors...
  22. ncbi Genetic epistasis in the VLDL catabolic pathway is associated with deleterious variations on triglyceridemia in obese subjects
    D Brisson
    Department of Medicine, Universite de Montreal, University of Montreal Community Genomic Medicine Center and Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Canada
    Int J Obes (Lond) 31:1325-33. 2007
    ..The epistatic effect of such variants on the risk profile associated with abdominal obesity remains to be elucidated...
  23. ncbi Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
    Science 316:1331-6. 2007
    ..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases...
  24. ncbi The S447X polymorphism of lipoprotein lipase: effect on the incidence of premature coronary disease and on plasma lipids
    Katia A Almeida
    Instituto do Coracao, Hospital das Clinicas, FM, USP, Sao Paulo, SP, Brazil
    Arq Bras Cardiol 88:297-303. 2007
    ..The objective of this study was to evaluate the effect of polymorphism S447X on plasma lipids of patients with premature coronary artery disease (CAD)...
  25. pmc Genetic and epigenetic inactivation of LPL gene in human prostate cancer
    Jin Woo Kim
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Cancer 124:734-8. 2009
    b>Lipoprotein lipase (LPL) is in chromosome 8p22, site of one of the most common somatic deletions in prostate tumors. Additionally, a CpG island (CGI) was identified in the LPL promoter region...
  26. pmc Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study
    Rahul C Deo
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    PLoS Genet 5:e1000342. 2009
    ..profiles -- HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), and triglycerides (TG) -- we identified the lipoprotein lipase (LPL) locus as harboring variants that account for interethnic variation in HDL-C and TG...
  27. doi Lipoprotein lipase is differentially expressed in prognostic subsets of chronic lymphocytic leukemia but displays invariably low catalytical activity
    Mahmoud Mansouri
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Leuk Res 34:301-6. 2010
    b>Lipoprotein lipase (LPL) expression has been shown to correlate with IGHV mutational status and to predict outcome in chronic lymphocytic leukemia (CLL)...
  28. pmc Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia
    R P Surendran
    Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Intern Med 272:185-96. 2012
    ..forms of hypertriglyceridaemia (HTG) are caused by mutations in genes that lead to the loss of function of lipoprotein lipase (LPL)...
  29. ncbi Human lipoprotein lipase. Analysis of the catalytic triad by site-directed mutagenesis of Ser-132, Asp-156, and His-241
    J Emmerich
    Molecular Disease Branch, National Heart Lung and Blood Institute, Bethesda, Maryland 20892
    J Biol Chem 267:4161-5. 1992
    b>Lipoprotein lipase (LPL) plays a central role in normal lipid metabolism as the key enzyme involved in the hydrolysis of triglycerides present in chylomicrons and very low density lipoproteins...
  30. pmc Amino acid substitution (Ile194----Thr) in exon 5 of the lipoprotein lipase gene causes lipoprotein lipase deficiency in three unrelated probands. Support for a multicentric origin
    H E Henderson
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    J Clin Invest 87:2005-11. 1991
    Studies on the molecular biology of lipoprotein lipase (LPL) deficiency have been facilitated by the availability of LPL gene probes and the recent characterization of gene mutations underlying human LPL deficiency...
  31. pmc A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries
    M V Monsalve
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    J Clin Invest 86:728-34. 1990
    b>Lipoprotein lipase (LPL) plays a crucial role in the regulation of lipoprotein metabolism by hydrolysing the core triglycerides of circulating chylomicrons and VLDL...
  32. ncbi Structure of the human lipoprotein lipase gene
    S S Deeb
    Department of Medicine, University of Washington, Seattle 98195
    Biochemistry 28:4131-5. 1989
    Human genomic clones that span the entire lipoprotein lipase (LPL) gene have been isolated and used to determine its structure...
  33. ncbi Human lipoprotein lipase complementary DNA sequence
    K L Wion
    Science 235:1638-41. 1987
    b>Lipoprotein lipase is a key enzyme of lipid metabolism that acts to hydrolyze triglycerides, providing free fatty acids for cells and affecting the maturation of circulating lipoproteins...
  34. pmc A mutation in the promoter of the lipoprotein lipase (LPL) gene in a patient with familial combined hyperlipidemia and low LPL activity
    W S Yang
    Department of Medicine, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 92:4462-6. 1995
    We have identified a naturally occurring mutation in the promoter of the lipoprotein lipase (LPL) gene...
  35. ncbi Lipoprotein lipase. Molecular model based on the pancreatic lipase x-ray structure: consequences for heparin binding and catalysis
    H van Tilbeurgh
    Laboratory of Cristallisation et Macromolecules Biologiques Centre National de la Recherche Scientifique, Faculte de Medecine Nord, Marseille, France
    J Biol Chem 269:4626-33. 1994
    b>Lipoprotein lipase and pancreatic lipase have about 30% sequence identity, suggesting a similar tertiary fold...
  36. ncbi The tissue-specific expression of lipoprotein lipase: implications for energy and lipoprotein metabolism
    R Zechner
    SFB Biomembrane Research Center, Institute of Medical Biochemistry, Kari Franzens University Graz, Austria
    Curr Opin Lipidol 8:77-88. 1997
    The dual function of lipoprotein lipase as a triglyceride hydrolase and a ligand/bridging factor for receptor-mediated lipoprotein uptake implies an important role of the enzyme in the distribution of fatty acids and lipoproteins among ..
  37. ncbi Potentially protective effects of the Ser447-Ter mutation of the lipoprotein lipase gene against the development of coronary artery disease in Japanese subjects via a beneficial lipid profile
    M Sawano
    Department of Cardiology, Juntendo University, Tokyo, Japan
    Jpn Circ J 65:310-4. 2001
    Several DNA variants at the lipoprotein lipase (LPL) gene locus have been found to be associated with the plasma lipid levels and the prevalence of coronary artery disease (CAD)...
  38. ncbi Common mutations in the lipoprotein lipase gene (LPL): effects on HDL-cholesterol levels in a Chinese Canadian population
    S H McGladdery
    Atherosclerosis Specialty Laboratory, Department of Pathology and Laboratory Medicine, University of British Columbia St Paul s Hospital, 1081 Burrard Street, Suite 180 20, V6Z 1Y6, Vancouver, BC, Canada
    Atherosclerosis 156:401-7. 2001
    ..b>Lipoprotein lipase (LPL) mutations have been associated with altered HDL-C concentrations in Caucasians but have not yet been ..
  39. ncbi Association of lipoprotein lipase Ser447Ter polymorphism with brain infarction: a population-based neuropathological study
    L Myllykangas
    Department of Pathology, University of Helsinki and the Helsinki University Central Hospital, Finland
    Ann Med 33:486-92. 2001
    Variants of the lipoprotein lipase (LPL) gene have been shown to influence serum lipid levels, risk of coronary heart disease and, as found recently, risk of clinical ischaemic cerebrovascular disease...
  40. ncbi Lipoprotein lipase: structure, function, regulation, and role in disease
    James R Mead
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, UK
    J Mol Med (Berl) 80:753-69. 2002
    b>Lipoprotein lipase (LPL) catalyses the hydrolysis of the triacylglycerol component of circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation...
  41. ncbi Lack of association of lipoprotein lipase gene polymorphisms with coronary artery disease in the Saudi Arab population
    Khaled K Abu-Amero
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Arch Pathol Lab Med 127:597-600. 2003
    Previous studies reported an association of certain polymorphisms in the lipoprotein lipase (LPL) gene with the risk of coronary artery disease (CAD); however, these studies were small and inconsistent...
  42. ncbi Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans
    Mark O Goodarzi
    Division of Medical Genetics, Department of Medicine, Cedars Sinai Medical Center and UCLA, Los Angeles, California, USA
    Genet Med 5:322-7. 2003
    To illustrate an approach of deriving haplotypes for genetic association studies, using the lipoprotein lipase (LPL) gene and coronary artery disease.
  43. ncbi Lipoprotein lipase is a gene for insulin resistance in Mexican Americans
    Mark O Goodarzi
    Division of Medical Genetics, Department of Pediatrics, Steven Spielberg Pediatric Research Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Diabetes 53:214-20. 2004
    The insulin resistance syndrome is increasingly recognized as a risk factor for cardiovascular disease. Lipoprotein lipase (LPL) is a candidate gene for components of the syndrome...
  44. ncbi The lipoprotein lipase S447X polymorphism and plasma lipids: interactions with APOE polymorphisms, smoking, and alcohol consumption
    J Lee
    National University of Singapore Genome Institute of Singapore Center for Molecular Epidemiology, Community, Occupational and Family Medicine, Singapore
    J Lipid Res 45:1132-9. 2004
    ..Interactions with APOE genotype, cigarette smoking, and alcohol intake reinforce the importance of examining genetic associations, such as this one, in the context of the population of interest...
  45. ncbi Missense mutation W86R in exon 3 of the lipoprotein lipase gene in a boy with chylomicronemia
    Daria Pasalic
    Department of Chemistry and Biochemistry, Zagreb University School of Medicine, Salata 3 HR 10000 Zagreb, Croatia
    Clin Chim Acta 343:179-84. 2004
    ..Familial LPL deficiency is a rare inborn error of metabolism caused by mutational change within the LPL gene, which leads to massive hypertriglyceridemia...
  46. ncbi Lipoprotein lipase gene polymorphism and lipid profile in coronary artery disease
    Belgin Susleyici Duman
    Department of Medical Biology, Kadir Has University, School of Medicine, Istanbul, Turkey
    Arch Pathol Lab Med 128:869-74. 2004
    b>Lipoprotein lipase (LPL) plays a central role in lipid metabolism, hydrolyzing triglyceride in chylomicrons and very-low-density lipoproteins...
  47. ncbi Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits
    Tomonaga Ichikawa
    Cardiovascular Disease Laboratory, Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
    Atherosclerosis 179:87-95. 2005
    b>Lipoprotein lipase (LPL) produced by macrophages is upregulated in the atherosclerotic lesions; however, it is not fully understood whether increased macrophage-derived LPL is pro-atherogenic...
  48. ncbi High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia
    D Heintel
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    Leukemia 19:1216-23. 2005
    We investigated the pattern of lipoprotein lipase (LPL) expression in B-cell chronic lymphocytic leukemia (B-CLL) and assessed its prognostic relevance. Expression of LPL mRNA as well as protein was highly restricted to leukemic B cells...
  49. ncbi Lipoprotein metabolism of pregnant women is associated with both their genetic polymorphisms and those of their newborn children
    Olivier S Descamps
    Epidemiology Unit, School of Public Health, Universite Catholique de Louvain, Brussels, Belgium
    J Lipid Res 46:2405-14. 2005
    ....
  50. ncbi Lipoprotein lipase gene is linked and associated with hypertension in Taiwan young-onset hypertension genetic study
    Pei Chen
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    J Biomed Sci 12:651-8. 2005
    ..However, the mechanism behind it is poorly understood. A positive linkage signal between Lipoprotein lipase (LPL) and young-onset hypertension has been identified by us as the strongest among 18 candidate genes...
  51. ncbi Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study
    Hans H Wittrup
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 91:1438-45. 2006
    Genetic variants in lipoprotein lipase may affect triglycerides, high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD).
  52. ncbi A novel nonsense mutation in the LPL gene in a Chinese neonate with hypertriglyceridemia
    Angel On kei Chan
    Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China
    Clin Chim Acta 368:120-4. 2006
    b>Lipoprotein lipase (LPL) deficiency is a rare autosomal recessive disorder characterized by hypertriglyceridemia. The genetic defect lies in a mutation of the LPL gene.
  53. ncbi Association of lipoprotein lipase Hind III and Ser 447 Ter polymorphisms with dyslipidemia in Asian Indians
    Venkatesan Radha
    Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialities Centre, Gopalapuram, Chennai, India
    Am J Cardiol 97:1337-42. 2006
    Studies have shown an association between the lipoprotein lipase gene and dyslipidemia and atherosclerosis in some populations...
  54. ncbi A systematic review and meta-analysis of the relationship between lipoprotein lipase Asn291Ser variant and diseases
    YaoMin Hu
    Division of Endocrinology, Department of Internal Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai 200127, China
    J Lipid Res 47:1908-14. 2006
    This systematic review attempted to summarize the associations between the Asn291Ser variant in the lipoprotein lipase (LPL) gene and dyslipidemia, the risk of type 2 diabetes mellitus (T2DM), and coronary heart disease (CHD)...
  55. ncbi A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology
    Jean Francois Blain
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Eur J Neurosci 24:1245-51. 2006
    Emerging evidences indicate a role for lipoprotein lipase (LPL) in degenerative states...
  56. pmc Subsets of SNPs define rare genotype classes that predict ischemic heart disease
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Hum Genet 120:865-77. 2007
    ..In this study we determined the utility of exonic and 5' SNPs in apolipoprotein E (APOE) and lipoprotein lipase (LPL) when considered singly and in combination for predicting incidence of IHD in 8,456 individuals from ..
  57. ncbi Suppression of endothelial or lipoprotein lipase in THP-1 macrophages attenuates proinflammatory cytokine secretion
    Guosong Qiu
    St Paul s Hospital, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
    J Lipid Res 48:385-94. 2007
    ..These results provide further insight into the specific metabolic and potential pathological roles of LPL and EL in human macrophages...
  58. ncbi Association of lipase lipoprotein polymorphisms with myocardial infarction and lipid levels
    Carolina de Oliveira Gigek
    Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, SP, Brazil
    Clin Chem Lab Med 45:599-604. 2007
    b>Lipoprotein lipase has an important role in lipid metabolism...
  59. ncbi The S447X variant of lipoprotein lipase gene is associated with metabolic syndrome and lipid levels among Turks
    Evrim Komurcu-Bayrak
    Department of Genetics, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey
    Clin Chim Acta 383:110-5. 2007
    We evaluated the relationship of the lipoprotein lipase (LPL) S447X variant with serum lipid levels and the metabolic syndrome (MS) in the Turkish Adult Risk Factor (TARF) study...
  60. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
    ..Genome-wide association is a promising approach to map genetic loci related to these heritable phenotypes...
  61. doi Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    Jaspal S Kooner
    National Heart and Lung Institute, Imperial College London, UK
    Nat Genet 40:149-51. 2008
    ..4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'...
  62. doi Polymorphisms associated with cholesterol and risk of cardiovascular events
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
    N Engl J Med 358:1240-9. 2008
    ..We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease...
  63. doi Common genetic variation near MC4R is associated with waist circumference and insulin resistance
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Pl, London W2 1PG, UK
    Nat Genet 40:716-8. 2008
    ..Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance...
  64. ncbi [The relation between gene of lipoprotein-lipase and carrier protein of cholesterol ethers and life duration in patients with chronic cerebral ischemia]
    I V Kostomarov
    Klin Med (Mosk) 86:22-6. 2008
    ....
  65. doi Polymorphisms of the lipoprotein lipase gene are associated with atherosclerotic cerebral infarction in the Chinese
    E Xu
    Institute of Neurosciences, The 2nd Affiliated Hospital of Guangzhou Medical College, 250 Changgang Dong RD, Guangzhou 510260, PR China
    Neuroscience 155:403-8. 2008
    b>Lipoprotein lipase (LPL), which plays an essential role in plasma lipoprotein metabolism and transportation, appears to be a risk factor for ischemic vascular diseases...
  66. doi Polygenic determinants of severe hypertriglyceridemia
    Jian Wang
    Vascular Biology Research Group 2 Clinical Trials Group, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Hum Mol Genet 17:2894-9. 2008
    ..At the extremes of a quantitative trait, such as severe HTG, are found the cumulative contributions of both multiple rare alleles with large genetic effects and common alleles with small effects...
  67. doi Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis
    Gurdeep S Sagoo
    United Kingdom HuGENet Coordinating Centre, Strangeways Research Laboratory, Cambridge, United Kingdom
    Am J Epidemiol 168:1233-46. 2008
    b>Lipoprotein lipase (LPL) is a key enzyme in lipoprotein metabolism and a major candidate gene for coronary heart disease (CHD)...
  68. pmc S447X variant of the lipoprotein lipase gene, lipids, and risk of coronary heart disease in 3 prospective cohort studies
    Majken K Jensen
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am Heart J 157:384-90. 2009
    b>Lipoprotein lipase (LPL) has a prominent role in the metabolism of triglycerides (TGs) and high-density lipoprotein cholesterol (HDL-C) and is a potential interesting target for the development of antiatherogenic treatment...
  69. doi Novel LPL mutations associated with lipoprotein lipase deficiency: two case reports and a literature review
    Amit R Rahalkar
    Department of Vascular Biology and Medicine, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, P O Box 5015, 100 Perth Drive, London, ON N6A5K8, Canada
    Can J Physiol Pharmacol 87:151-60. 2009
    b>Lipoprotein lipase (LPL) is a key enzyme involved with hydrolysis and removal of triglycerides from plasma. LPL deficiency is a rare condition with an estimated prevalence of 1 in 106...
  70. pmc Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample
    Matthew B Lanktree
    Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Lipid Res 50:1487-96. 2009
    ..The findings indicate the potential utility of the Illumina CVD beadchip, but they underscore the need to consider meta-analysis of results from commonly studied clinical or epidemiological samples...
  71. pmc GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4
    William K Sonnenburg
    Department of Biotherapeutics, Lexicon Pharmaceuticals, Inc, 8800 Technology Forest Place, The Woodlands, TX 77381, USA
    J Lipid Res 50:2421-9. 2009
    ..Moreover, therapeutic agents that prevent LPL inhibition by ANGPTL4 or, to a lesser extent, ANGPTL3, may benefit individuals with hyperlipidemia caused by gene mutations associated with decreased LPL stability...
  72. pmc Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin
    Caren E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:327-32. 2010
    Apolipoprotein A5 (APOA5) and lipoprotein lipase (LPL) proteins interact functionally to regulate lipid metabolism, and single-nucleotide polymorphisms (SNPs) for each gene have also been associated independently with obesity risk...
  73. pmc Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
    Wei Chen
    Center for Statistical Genetics, Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:7401-6. 2010
    ..Our studies extend the catalog of AMD associated loci, help identify individuals at high risk of disease, and provide clues about underlying cellular pathways that should eventually lead to new therapies...
  74. pmc Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
    Christopher T Johansen
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Nat Genet 42:684-7. 2010
    ..1% of affected individuals and 15.3% of controls (P = 2.6 x 10(-5)). Considering rare variants in these genes incrementally increased the proportion of genetic variation contributing to HTG...
  75. pmc A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, Missouri, USA
    Diabetes 60:1329-39. 2011
    ..4% of systolic blood pressure. CONCLUSIONS Qualitative and quantitative pleiotropic tests on pairs of traits indicate that a small portion of the covariation in these traits can be explained by the reported common genetic variants...
  76. doi Association between schizophrenia and single nucleotide polymorphisms in lipoprotein lipase gene in a Han Chinese population
    Cui Xie
    Laboratory of Disorder Genes and Pharmacogenomics Research Center, Institute of Life Sciences, Chongqing University of Medical Sciences, College of Pharmacy, Chongqing University of Medical Sciences, P R China
    Psychiatr Genet 21:307-14. 2011
    ..b>Lipoprotein lipase (LPL), as the key enzyme of triglyceride hydrolysis, is expressed in the brain regions functionally relevant ..
  77. doi Eicosapentaenoic acid administration attenuates the pro-inflammatory properties of VLDL by decreasing its susceptibility to lipoprotein lipase in macrophages
    Yasutaka Jinno
    Development Research, Pharmaceutical Research Center, Mochida Pharmaceutical Co, Ltd, 722 Jimba aza Uenohara, Gotemba, Shizuoka 412 8524, Japan
    Atherosclerosis 219:566-72. 2011
    ..Inhibition of lipoprotein lipase (LPL) appeared to suppress inflammation and triglyceride accumulation by Ctrl-VLDL suggesting that ..
  78. ncbi Effects of lipoprotein lipase gene variations, a high-carbohydrate low-fat diet, and gender on serum lipid profiles in healthy Chinese Han youth
    Xin Huang
    Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine and State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China
    Biosci Trends 5:198-204. 2011
    A high-carbohydrate low-fat (HC/LF) diet and lipoprotein lipase gene (LPL) Ser447Stop and Hind III polymorphisms have separately been found to be associated with triacylglycerol (TG) and high density lipoprotein cholesterol (HDL-C)...
  79. doi A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population
    Aihua Tan
    Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi 530021, China
    Hum Mol Genet 21:1658-64. 2012
    ..Just one drink can increase TG level in susceptible individuals who carry the GG genotype, while individuals carrying AA/AG genotypes may actually benefit from moderate drinking...
  80. pmc The lipoprotein lipase (LPL) S447X gain of function variant involves increased mRNA translation
    Gouri Ranganathan
    The Central Arkansas Veterans Healthcare System and the Department of Medicine, Division of Endocrinology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States
    Atherosclerosis 221:143-7. 2012
    ..The mechanism for the LPL gain-in-function is not clear. LPL translation is regulated by epinephrine by an RNA-protein complex, consisting of PKA subunits and an A kinase anchoring protein (AKAP), which targets the 3'UTR...
  81. doi Association of LPL gene variant and LDL, HDL, VLDL cholesterol and triglyceride levels with ischemic stroke and its subtypes
    Anjana Munshi
    Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, India
    J Neurol Sci 318:51-4. 2012
    b>Lipoprotein lipase (LPL) plays an important role in lipid metabolism by hydrolyzing triglycerides in chylomicrons and very low density lipoproteins...
  82. ncbi Six lipoprotein lipase gene polymorphisms, lipid profile and coronary stenosis in a Tunisian population
    Lamia Rebhi
    Biochemistry Department, Sahloul University Hospital, 4054 Sousse, Tunisia
    Mol Biol Rep 39:9893-901. 2012
    b>Lipoprotein lipase (LPL) is the rate-limiting enzyme in the hydrolysis of triglyceride-rich lipoprotein particles (Chylomicrons and very-low-density lipoprotein)...
  83. doi Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed
    Elena Makoveichuk
    Department of Medical Biosciences, Physiological Chemistry Umeå University, SE 901 87 Umea, Sweden
    Biochem Biophys Res Commun 425:138-43. 2012
    b>Lipoprotein lipase (LPL) hydrolyzes triglycerides in plasma lipoproteins causing release of fatty acids for metabolic purposes in muscles and adipose tissue...
  84. pmc Characterization of the human lipoprotein lipase (LPL) promoter: evidence of two cis-regulatory regions, LP-alpha and LP-beta, of importance for the differentiation-linked induction of the LPL gene during adipogenesis
    S Enerback
    Department of Molecular Biology, University of Goteborg, Sweden
    Mol Cell Biol 12:4622-33. 1992
    When preadipocytes differentiate into adipocytes, several differentiation-linked genes are activated. Lipoprotein lipase (LPL) is one of the first genes induced during this process...
  85. ncbi Common variants in the lipoprotein lipase gene, but not those in the insulin receptor substrate-1, the beta3-adrenergic receptor, and the intestinal fatty acid binding protein-2 genes, influence the lipid phenotypic expression in familial combined hyperli
    Filomena Campagna
    Dipartimento di Terapia Medica, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Metabolism 51:1298-305. 2002
    ..Therefore, we have evaluated the association of the common variants in the lipoprotein lipase (LPL) (D9N, N291S, and S447X), insulin receptor substrate-1 (IRS-1) (G972R), fatty acid binding protein-2 (..
  86. pmc The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion
    Shu Fen Wung
    College of Nursing, University of Arizona, Tucson, AZ, USA
    Lipids Health Dis 5:19. 2006
    b>Lipoprotein Lipase (LPL), a key enzyme in lipid metabolism, catalyzes the hydrolysis of triglycerides (TG) from TG-rich lipoproteins, and serves a bridging function that enhances the cellular uptake of lipoproteins...
  87. ncbi Resequencing genomic DNA of patients with severe hypertriglyceridemia (MIM 144650)
    Jian Wang
    Vascular Biology Research Group, Robarts Research Institute and Schulich School of Medicine and Dentistry, London, Ontario, Canada
    Arterioscler Thromb Vasc Biol 27:2450-5. 2007
    ..We therefore resequenced 3 candidate genes, namely LPL, APOC2, and APOA5, to search for accumulation of missense mutations in patients with severe HTG compared with normolipidemic subjects...
  88. pmc Associations of lipoprotein lipase gene polymorphisms with longitudinal plasma lipid trends in young adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study
    Weihong Tang
    University of Minnesota, Minneapolis, USA
    Circ Cardiovasc Genet 3:179-86. 2010
    ..studies in European Americans have reported several single-nucleotide polymorphisms (SNPs) in the lipoprotein lipase gene associated with plasma levels of high-density lipoprotein cholesterol (HDL-C) and triglycerides...
  89. ncbi A heterozygous mutation (the codon for Ser447----a stop codon) in lipoprotein lipase contributes to a defect in lipid interface recognition in a case with type I hyperlipidemia
    J Kobayashi
    Second Department of Internal Medicine, School of Medicine, Chiba University, Japan
    Biochem Biophys Res Commun 182:70-7. 1992
    Previously, we reported a case with type I hyperlipidemia due to a lipid interface recognition deficiency in lipoprotein lipase (LPL) (1)...
  90. ncbi Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery disease
    L Masana
    Servei de Medicina Interna de Reus C, St Llorenc s n 43201, Reus, Spain
    Clin Sci (Lond) 100:183-90. 2001
    Fifteen common polymorphic variants at six loci (apolipoproteins AI, B, CIII and E, hepatic lipase and lipoprotein lipase) involved in plasma lipid transport have been studied in 210 northern Spanish men, of whom 98 had proven coronary ..
  91. ncbi Influence of lipoprotein lipase serine 447 stop polymorphism on tracking of triglycerides and HDL cholesterol from childhood to adulthood and familial risk of coronary artery disease: the Bogalusa heart study
    W Chen
    Department of Epidemiology, Tulane Center for Cardiovascular Health, Tulane School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2140, New Orleans, LA 70112, USA
    Atherosclerosis 159:367-73. 2001
    The effects of the lipoprotein lipase (LPL) Serine 447 Stop (S447X) polymorphism on high-density lipoprotein cholesterol (HDLC) and triglycerides (TG) have been demonstrated...
  92. ncbi Effect of gender on phenotypic expression of the S447X mutation in LPL: the Copenhagen City Heart Study
    Hans H Wittrup
    Department of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Atherosclerosis 165:119-26. 2002
    ..97; P=0.98). The S447X mutation is associated with anti-atherogenic effects on TG and HDL cholesterol in both genders, and with a moderate protective effect on risk of ischemic heart disease in men...
  93. ncbi Effects of high fat diets on hibernation and adipose tissue in Turkish hamsters
    T J Bartness
    Department of Psychology, Georgia State University, Atlanta
    J Comp Physiol B 161:451-9. 1991
    ..or within the diet groups for any of the BAT measures [uncoupling protein content, mitochondrial mass, lipoprotein lipase (LPL) activity, and in vivo lipogenesis], nor were there significant effects of the diet on these measures...
  94. ncbi Effects of early pregnancy on regional adipose tissue metabolism
    U B Lindberg
    Department of Obstetrics and Gynecology, Sahlgren's Hospital, , Sweden
    Horm Metab Res 23:25-9. 1991
    ..Both during pregnant and non-pregnant conditions, a higher lipoprotein lipase (LPL) activity was seen in the femoral compared to the abdominal region, but the LPL activity was not ..
  95. ncbi Relationship between post-heparin plasma lipases, triglycerides and high density lipoproteins in normal subjects
    R L Jackson
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Ohio
    Horm Metab Res 22:289-94. 1990
    The relationship between plasma lipids and lipoproteins and the lipolytic activities of post-heparin plasma lipoprotein lipase (LpL) and hepatic-triglyceride lipase (H-TGL) was examined in normal subjects...
  96. ncbi Tissue-specific alterations in lipoprotein lipase activity in the rat after chronic infusion of isoproterenol
    Y Deshaies
    Department of Physiology, School of Medicine, Laval University, , Canada
    Horm Metab Res 25:13-6. 1993
    ..of sustained exposure to the nonspecific beta adrenergic agonist isoproterenol on the activity of lipoprotein lipase (LPL) in tissues that are sites for a large portion of the intravascular hydrolysis of triacylglycerols...
  97. ncbi Glycosylation of lipoprotein lipase in human subcutaneous lipomas
    J W Park
    Department of Biochemistry, Chonbuk National University Medical School, Chonju, Republic of Korea
    Horm Metab Res 28:7-10. 1996
    Glycosylation of lipoprotein lipase (LPL) was studied in human subcutaneous lipomas...
  98. ncbi Postprandial serum lipids and tissue lipoprotein lipase are acutely altered in rats by the alpha-glucosidase inhibitor acarbose
    F Picard
    Department of Physiology, School of Medicine, Laval University, , QC, Canada
    Horm Metab Res 28:377-80. 1996
    ..attenuation of postprandial glycemia and insulinemia on plasma lipid concentrations and on tissue lipoprotein lipase (LPL) activity. Rats were fed a high-sucrose diet ad libitum for two weeks...
  99. ncbi The relation between plasma lipid levels and pseudocholinesterase activity in hypothyroidism
    L Popovic
    Department of Surgery, Clinical Medical Center Rebro, Zagreb, Croatia
    Horm Metab Res 30:137-40. 1998
    ..of PChE elicited by thyroid hormone deficiency in men and rats are similar to the respective changes in lipoprotein lipase (LPL) activity, observed by other authors...
  100. ncbi Inhibition of insulin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) secretion by octreotide has no effect on post-heparin plasma lipoprotein lipase activity
    L R Ranganath
    Department of Chemical Pathology, Epsom General Hospital, Surrey, UK
    Horm Metab Res 31:262-6. 1999
    ..insulinotropic polypeptide, GIP; glucagon-like peptide-1, GLP-1) secretion on the activation of lipoprotein lipase (LPL) in six lean and six obese age-matched women...
  101. ncbi The role of TNF-alpha in human adipose tissue: prevention of weight gain at the expense of insulin resistance?
    F Hube
    German Diabetes Research Institute at the Heinrich Heine University, Dusseldorf
    Horm Metab Res 31:626-31. 1999
    ..markers of fat cell differentiation, such as peroxisome proliferator-activated receptor (PPAR)-gamma2, lipoprotein lipase (LPL), glycerol-3-phosphate dehydrogenase (GPDH) and GLUT4...

Research Grants62

  1. Anthony W Ferrante; Fiscal Year: 2016
    ..increases basal lipolysis, that ATMs are the primary source of both insulin-like growth factor-1 (Igf1) and lipoprotein lipase (Lpl) in obese adipose tissue and surprisingly that obesity rather then inducing a classical inflammatory ..
  2. Antibodies to Define Molecular Mechanisms of Hypertriglyceridemia
    Stephen G Young; Fiscal Year: 2010
    ..Hypertriglyceridemia is caused by inherited defects in lipoprotein lipase (LPL), but the etiology of most cases of hypertriglyceridemia remains mysterious...
  3. LPL-Deficient Cats-A Quantitative Model of Gene Delivery
    PHILIP RICHARD VULLIET; Fiscal Year: 2010
    ..We have identified a novel animal model, the lipoprotein lipase-deficient (LPL-/-) cat, that will provide this essential data...
  4. Robert H Eckel; Fiscal Year: 2014
    ..is to uncover mechanisms of body weight regulation through a newly discovered pathway mediated by the enzyme lipoprotein lipase (LPL) in the neuron...
  5. NUTRITION AND LIPOPROTEIN LIPASE-MOLECULAR MECHANISMS
    SUSAN FRIED; Fiscal Year: 1992
    ..is the rate of uptake of circulating triglycerides which is controlled by the activity of the enzyme lipoprotein lipase (LPL)...
  6. IRA JAY GOLDBERG; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Lipoprotein lipase (LpL), the primary enzyme responsible for the hydrolysis of triglyceride within lipoproteins, modulates plasma levels of all plasma lipoproteins and allows cellular uptake of fatty ..
  7. Nir Uriel; Fiscal Year: 2014
    ..We will also measure post heparin plasma lipoprotein lipase (LPL) activity to assess the availability of circulating lipoprotein-derived FFA in each group of subjects...
  8. Regulation of lipoprotein lipase in adipocytes
    Philip A Kern; Fiscal Year: 2011
    ..Will this cause lipid partitioning into adipose tissue, and improve insulin sensitivity? Aim 6. Examine insulin sensitivity and other phehotypic feaitures ofid-AKAPI knocl<out mice. ..
  9. Jianhua Shao; Fiscal Year: 2016
    ..Although there was no change in placenta mass, remarkably increased lipoprotein lipase (LPL) gene expressions were observed in placentas from obese dams...
  10. Ann Hwee Lee; Fiscal Year: 2015
    ..deficient mice displayed severe hypertriglyceridemia secondary to inefficient TG clearance catalyzed by lipoprotein lipase (LPL)...
  11. Adiponectin and Regulation of Triglyceride Metabolism
    Jianhua Shao; Fiscal Year: 2012
    ..Interestingly, postheparin plasma lipoprotein lipase (LPL) activity, as well as LPL and VLDL receptor gene expression in skeletal muscle, was significantly ..
  12. TISSUE SPECIFIC REGULATION OF LIPOPROTEIN LIPASE
    Robert Eckel; Fiscal Year: 2004
    b>Lipoprotein lipase (LPL) is a secretory glycoprotein which contributes to the delivery of lipid fuels to tissues where they are predominantly stored (adipose tissue) or oxidized (muscle)...
  13. Stephen G Young; Fiscal Year: 2016
    ..provided by applicant): The objectives of this proposal are to identify the structural features of lipoprotein lipase (LPL) required for binding to GPIHBP1 and to define mechanisms by which LPL is transported across ..
  14. William B Kinlaw; Fiscal Year: 2016
    ..This employs the secreted enzyme lipoprotein lipase (LPL), which releases FAs from lipoproteins, and CD36, the channel for FA uptake...
  15. Jianhua Shao; Fiscal Year: 2015
    ..higher levels of: 1) body fat;2) liver triglycerid content and expression of de novo lipogenic genes and 3) lipoprotein lipase (LPL) in fat tissue, compared with Adipoq-/- fetuses...
  16. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..We will employ Lrat-/- and Rbp-/- mice and mice expressing lipoprotein lipase (LpL) solely in skeletal muscle (MCK-LpL0 mice) to investigate these relationships...
  17. PHYSIOLOGICAL FACTORS AFFECTING HUMAN LACTATION
    Margaret Neville; Fiscal Year: 2002
    b>Lipoprotein lipase (LPL) is responsible for hydrolysis of plasma triglycerides making their component fatty acids available for metabolism or synthesis into lipid. It plays a major role in the synthesis of milk fat...
  18. PHYSIOLOGICAL FACTORS AFFECTING HUMAN LACTATION
    Margaret Neville; Fiscal Year: 1993
    b>Lipoprotein lipase (LPL) is responsible for hydrolysis of plasma triglycerides making their component fatty acids available for metabolism or synthesis into lipid. It plays a major role in the synthesis of milk fat...
  19. Hepatic Lipase and HCV Infection
    Tianyi Wang; Fiscal Year: 2010
    ..we found that HCV- infected human hepatoma cells increased their expressions of hepatic lipase (HL) and lipoprotein lipase (LPL), both of which are key enzymes in maintaining circulating lipoprotein levels and can facilitate lipid ..
  20. Adiponectin regulates nutrient transport in the placenta
    Theresa L Powell; Fiscal Year: 2009
    ..Also, adiponectin infusion into pregnant rats caused a decrease in glucose transporter 3 and lipoprotein lipase (LPL) mRNA expression...
  21. Jheem D Medh; Fiscal Year: 2014
    ..This proposal is aimed at understanding the mechanisms and signaling pathways by which down- regulation of lipoprotein lipase (LPL) leads to improved insulin sensitivity in muscle cells...
  22. The role of b-carotene in maternal-fetal nutrition
    Loredana Quadro; Fiscal Year: 2013
    ..will also use mice lacking low density lipoprotein receptor (LDLr) or class B scavenger receptor (SR-BI) or lipoprotein lipase (LPL) to investigate the role of these key players of the lipid metabolism in facilitating the maternal-..
  23. Kiran Musunuru; Fiscal Year: 2016
    ..a protein exclusively synthesized in liver and secreted into the bloodstream, has been reported to inhibit lipoprotein lipase (encoded by LPL) and endothelial lipase (encoded by LIPG), increasing plasma TG and HDL-C levels in rodents...
  24. New Avenues in GPIHBP1 Research
    Anne Beigneux; Fiscal Year: 2012
    ..g., heart, muscle, fat) and because GPIHBP1 binds both lipoprotein lipase (LPL) and chylomicrons, we suspect that GPIHBP1 serves as a platform for the metabolic processing of ..
  25. DANIEL JAMES RADER; Fiscal Year: 2016
    ..also established that all three members of the subfamily of extracellular lipases that act on lipoproteins, lipoprotein lipase (LPL), hepatic lipase (HL), and endothelial lipase (EL), are significantly associated with variation in HDL-..
  26. IRA JAY GOLDBERG; Fiscal Year: 2015
    ..Mice with a deletion of the triglyceride lipolysis enzyme, lipoprotein lipase (LpL, mice denoted hLpL0) have a similar energy use as hearts that are stressed with increased afterload, ..
  27. LIPOPROTEIN LIPASE AND PREECLAMPSIA
    Carl Hubel; Fiscal Year: 2004
    ..b>Lipoprotein lipase (LPL) plays a vital role in the clearance of triglycerides from the circulation...
  28. Mechanism and physiology of DUF1222-assisted lipase maturation
    SASKIA NEHER; Fiscal Year: 2013
    Description: Hydrolysis of triacylglycerols by lipoprotein lipase (LPL) is essential for normal lipid metabolism. LPL does not fold and function properly without a newly identified, transmembrane protein, lipase maturation factor (LMF1)...
  29. REGULATION OF LIPOPROTEIN LIPASE IN HUMAN ADIPOCYTES
    PHILIP KERN; Fiscal Year: 1990
    Adipose tissue lipoprotein lipase (LPL) hydrolyses the core of triglyceride-rich lipoproteins into free fatty acids...
  30. LIPOPROTEIN LIPASE MODULATION OF TISSUE LIPID UPTAKE
    JOSEPH OBUNIKE; Fiscal Year: 1999
    b>Lipoprotein lipase (LPL) is the major enzyme responsible for hydrolysis of triglyceride (TG) molecules present in circulating lipoproteins...
  31. Regulation of Lipoprotein Lipase by Insulin
    VICTORIA KNUTSON; Fiscal Year: 2003
    b>Lipoprotein lipase (LPL) is the rate-limiting enzyme in the hydrolysis of serum triglycerides associated with the lipoprotein particles VLDL and chylomicrons...
  32. EFFECTS OF OMEGA-3 FATTY ACIDS ON LIPID TRANSPORT
    Andre Bensadoun; Fiscal Year: 1991
    ..hypothesis is that w3 fatty acids when substituted for w6 fatty acids in membranes enhance the activity of lipoprotein lipase (LPL) and hepatic lipase (HL)...
  33. EXPRESSION OF APOLIPOPROTEIN GENES IN TRANSGENIC RABBITS
    John Taylor; Fiscal Year: 2001
    The overall objective is to understand how apolipoprotein (apo) E, hepatic lipase (HL), apoC-III apoA-II, and lipoprotein lipase (LPL) interact to control the clearance of chylomicron and very low density lipoprotein (VLDL) remnants and ..
  34. Race, Lipoprotein Lipase and Obesity after Menopause
    Andrew Goldberg; Fiscal Year: 2007
    ..The hypothesis is that postmenopausal AA women have a higher skeletal muscle lipoprotein lipase (SM-LPL) and a lower adipose tissue LPL (AT-LPL) activity that leads to the preferential accumulation of TG ..
  35. LIPOPROTEIN LIPASE, NUTRITION AND NERVE MYELINATION
    Robert Eckel; Fiscal Year: 2003
    b>Lipoprotein lipase (LPL) is a hydrolytic enzyme which releases fatty acids and monoacylglyerol from nutrient-dependent triglyceride-rich lipoproteins [chylomicrons and very low density lipoproteins (VLDL)] and regulates the partitioning ..
  36. Lipolytic Mechanisms of PPAR Activation
    Jorge Plutzky; Fiscal Year: 2007
    ..Data is presented establishing lipoprotein lipase (LPL), the central enzyme in triglyceride-rich lipoprotein metabolism, as an endogenous mechanism for ..
  37. RADIOIMMUNOASSAY FOR HUMAN LIPOPROTEIN LIPASE
    Andre Bensadoun; Fiscal Year: 1992
    Human lipoprotein lipase (LPL) and hepatic lipase (HL) will be sequenced and structural domains on these enzymes identified. Several strategies will be employed...
  38. EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITY
    Ira Goldberg; Fiscal Year: 2009
    b>Lipoprotein lipase (LpL) is the principal enzyme responsible for hydrolysis of triglyceride in circulating lipoproteins...
  39. LIPOPROTEIN LIPASE DEFICIENCY AND HUMAN BRAIN FUNCTION
    M Murthy; Fiscal Year: 2001
    DESCRIPTION: (adapted from applicant's abstract) Lipoprotein lipase (LPL) plays a crucial role in the maturation and homeostasis of plasma lipoproteins...
  40. Regulation of lipoprotein lipase in adipocytes
    PHILIP KERN; Fiscal Year: 2005
    DESCRIPTION (Scanned from the Applicant's Description): Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism and adipocyte biology...
  41. EFFECTS OF SEX STEROIDS OF ADIPOCYTE LIPOPROTEIN LIPASE
    PER HENRIK IVERIUS; Fiscal Year: 1992
    b>Lipoprotein lipase (LPL) is a secretory enzyme that has a key role in the metabolism of plasma triglycerides, the distribution of metabolic fuels and perhaps also in the regulation of fat cell size...
  42. MENOPAUSE, LPL GENOTYPE AND METABOLISM AFTER WEIGHT LOSS
    Andrew Goldberg; Fiscal Year: 2004
    This research is designed to determine whether obese postmenopausal women with a common polymorphism in the lipoprotein lipase (LPL) PvuII gene, i.e...
  43. REGULATION OF LIPOPROTEIN LIPASE SYNTHESIS
    CLAY SEMENKOVICH; Fiscal Year: 1991
    ..allow the candidate to develop into an independent biomedical investigator while studying rat adipose tissue lipoprotein lipase. Lipoprotein lipase (LPL) is the enzyme responsible for the rate-limiting step in plasma triglyceride ..
  44. Mechanism and physiology of DUF1222-assisted lipase maturation
    SASKIA NEHER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Description: Hydrolysis of triacylglycerols by lipoprotein lipase (LPL) is essential for normal lipid metabolism...
  45. Study of the Dynamic Binding, Structure-Function of CIII
    EMELITA BREYER; Fiscal Year: 2007
    ..provided by applicant): Recent study shows that Apolipoprotein CIII (CIII) specifically binds and inhibits Lipoprotein Lipase (LpL) and Hepatic Lipase (HL) enzymes...
  46. Role of PPAR-gamma Isoforms in Regulation of Macrophage apoE & LPL Expression
    Jheem Medh; Fiscal Year: 2006
    ..the effects of individual PPAR-g isoforms on 2 proteins secreted by macrophages, apolipoprotein E (apoE) and lipoprotein lipase (LPL)...
  47. ADIPOSE DISTRIBUTION AND ADRENERGIC MECHANISMS IN AGING
    Robert Schwartz; Fiscal Year: 1993
    ..Furthermore, there is some in vitro evidence that adipose tissue lipoprotein lipase (AT-LPL), the rate limiting enzyme for triglyceride (TG) storage, is also regulated by adrenergic mechanisms ..
  48. DYSREGULATION OF CETP AND LPL IN THE DIABETIC CYNOMOLGUS
    John Bagdade; Fiscal Year: 1993
    ..We have shown in IDDM patients that CIT leads to peripheral hyperinsulinism and stimulation of lipoprotein lipase (LpL) which alters the surface properties of larger VLDL and enhances their affinity for cholesterol ester ..
  49. Endogenous Mechanisms of PPAR Modulation
    Jorge Plutzky; Fiscal Year: 2005
    ..Recently, we reported lipoprotein lipase (LPL) acts on circulating lipoproteins in a specific and selective manner to generate PPARalpha ligands...
  50. EFFECTS OF IDDM ON LIPOPROTEIN REMODELING AND FUNCTION
    John Bagdade; Fiscal Year: 1993
    ..This unphysiologic mode of Insulin delivery leads to peripheral hyperinsulinism, stimulation of lipoprotein lipase (LpL), and alteration of the surface properties of larger VLDL particles, Increasing their affinity for ..
  51. Lipids and gene regulation in skeletal muscle
    THEODORE ZDERIC; Fiscal Year: 2004
    ..provided by applicant): The overall purpose of this research training project is to study the regulation of lipoprotein lipase (LPL) as it relates to physical inactivity and muscle free fatty acids...
  52. RUNNING INDUCED INCREASE IN MUSCLE LPL MRNA
    MARC HAMILTON; Fiscal Year: 2000
    DESCRIPTION (Adapted from the applicant's abstract): Significant evidence suggests that skeletal muscle lipoprotein lipase (LPL) activity is a major determinant of triglyceride and lipoprotein metabolism...
  53. Functional Characterization-Lipoprotein Lipase Mutations
    M Kamboh; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Lipoprotein lipase (LPL) enzyme plays a pivitol role in lipid metabolism by hydrolyzing triglyceride (TG) rich lipoprotein particles...
  54. Lipoprotein lipase in myocyte fuel partitioning
    WARREN CAPELL; Fiscal Year: 2007
    ..b>Lipoprotein lipase (LPL) hydrolyzes lipoprotein TG, making lipoprotein-derived fatty acids (LPFA) available for uptake...
  55. Lipoprotein lipase in fatty acid partitioning
    WARREN CAPELL; Fiscal Year: 2004
    ..Lipoproteins interact with lipoprotein lipase (LPL), hydrolyzing their TG and making lipoprotein fatty acids (LPFA) available to cells...
  56. LINDA ANNE BARBOUR; Fiscal Year: 2014
    ....
  57. Genetic and behavioral effects on high-density lipoprotein: The Look AHEAD Study
    Jeanne M McCaffery; Fiscal Year: 2013
    ..In this application, we propose to identify specific genes that predict individual differences in HDL response to behavioral intervention to help identify individuals that struggle with improving HDL despite behavioral efforts. ..
  58. Endothelial Lipase: a novel therapeutic target for HDL and atherosclerosis
    XIAOMIN contact FAN; Fiscal Year: 2010
    ..This antibody will be isolated using our novel technology platform that provides a rapid and efficient means of identifying useful antibodies that can be used directly in patients. ..
  59. Purchase of AB Sciex QTRAP 5500 System
    Papasani V Subbaiah; Fiscal Year: 2012
    ..Therefore, availability of a state-of-the-art dedicated equipment for analysis of various types of lipids, lipd-derived second messengers and bioactive phospho- and sphingo-lipids will enable the currently NIH funded and non-..
  60. Michael Ibba; Fiscal Year: 2015
    ..Specifically, we will determine: i) The structural and functional basis of lysyl-tRNA's role in lipd modification. ii) The molecular basis of divergent substrate recognition by lysyl-tRNA synthetase and PoxA...
  61. NICHOLAS EUGENE DICKENSON; Fiscal Year: 2014
    ..in the virulece of Shigella, the specific aims of this investigation are to: 1) determine the role of host cell lipd raft components and membrane phases on S...
  62. Epidemiology of Gene-Alcohol Interactions and Lipids
    Alanna C Morrison; Fiscal Year: 2013
    ..proposed research will leverage the full scope of this resource to identify gene-alcohol interactions influencing lipd levels, with replication facilitated through pre-arranged collaborations with the CARDIA Study [N~3,750] and the ..