LITAF

Summary

Gene Symbol: LITAF
Description: lipopolysaccharide induced TNF factor
Alias: PIG7, SIMPLE, TP53I7, lipopolysaccharide-induced tumor necrosis factor-alpha factor, LPS-induced TNF-alpha factor, lipopolysaccharide-induced TNF-alpha factor, p53-induced gene 7 protein, small integral membrane protein of lysosome/late endosome, tumor protein p53 inducible protein 7
Species: human
Products:     LITAF

Top Publications

  1. Lee S, Olzmann J, Chin L, Li L. Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways. J Cell Sci. 2011;124:3319-31 pubmed publisher
    Mutations in SIMPLE cause an autosomal dominant, demyelinating form of peripheral neuropathy termed Charcot-Marie-Tooth disease type 1C (CMT1C), but the pathogenic mechanisms of these mutations remain unknown...
  2. Polyak K, Xia Y, Zweier J, Kinzler K, Vogelstein B. A model for p53-induced apoptosis. Nature. 1997;389:300-5 pubmed
    ....
  3. Tang X, Fenton M, Amar S. Identification and functional characterization of a novel binding site on TNF-alpha promoter. Proc Natl Acad Sci U S A. 2003;100:4096-101 pubmed
    ..Previously, a transcription factor, termed lipopolysaccharide-induced TNF-alpha factor (LITAF), was found to regulate TNF-alpha gene expression...
  4. Lacerda A, Hartjes E, Brunetti C. LITAF mutations associated with Charcot-Marie-Tooth disease 1C show mislocalization from the late endosome/lysosome to the mitochondria. PLoS ONE. 2014;9:e103454 pubmed publisher
    ..Mutations in LITAF have been shown to be causative for CMT type 1C disease...
  5. Latour P, Gonnaud P, Ollagnon E, Chan V, Perelman S, Stojkovic T, et al. SIMPLE mutation analysis in dominant demyelinating Charcot-Marie-Tooth disease: three novel mutations. J Peripher Nerv Syst. 2006;11:148-55 pubmed
    ..type 1C (CMT1C) is caused by mutations in the small integral membrane protein of the lysosome/late endosome (SIMPLE)...
  6. Beauvais K, Furby A, Latour P. Clinical, electrophysiological and molecular genetic studies in a family with X-linked dominant Charcot-Marie-Tooth neuropathy presenting a novel mutation in GJB1 Promoter and a rare polymorphism in LITAF/SIMPLE. Neuromuscul Disord. 2006;16:14-8 pubmed
    ..of Charcot-Marie-Tooth disease with dominant inheritance, five genes have been incriminated: PMP22, MPZ, LITAF/SIMPLE, EGR2 (CMT1A to D), and GJB1 (CMTX)...
  7. Saifi G, Szigeti K, Wiszniewski W, Shy M, Krajewski K, Hausmanowa Petrusewicz I, et al. SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation. Hum Mutat. 2005;25:372-83 pubmed
    ..Recently, SIMPLE/LITAF was shown to be responsible for an autosomal dominant demyelinating form of CMT linked to 16p (CMT1C)...
  8. Myokai F, Takashiba S, Lebo R, Amar S. A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment. Proc Natl Acad Sci U S A. 1999;96:4518-23 pubmed
    ..that its induction was dependent on LPS activation of THP-1 cells; hence, the name LPS-induced TNF-alpha factor (LITAF). Inhibition of LITAF mRNA expression in THP-1 cells resulted in a reduction of TNF-alpha transcripts...
  9. Bennett C, Shirk A, Huynh H, Street V, Nelis E, Van Maldergem L, et al. SIMPLE mutation in demyelinating neuropathy and distribution in sciatic nerve. Ann Neurol. 2004;55:713-20 pubmed
    ..neuropathy caused by missense mutations in the small integral membrane protein of lysosome/late endosome (SIMPLE) gene...
  10. Ludes Meyers J, Kil H, Bednarek A, Drake J, Bedford M, Aldaz C. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene. 2004;23:5049-55 pubmed
    ..The binding to one of these candidates, small membrane protein of the lysosome/late endosome (SIMPLE), was further analysed, and we observed that a specific PPSY motif in the SIMPLE amino-acid sequence was required ..

Detail Information

Publications62

  1. Lee S, Olzmann J, Chin L, Li L. Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways. J Cell Sci. 2011;124:3319-31 pubmed publisher
    Mutations in SIMPLE cause an autosomal dominant, demyelinating form of peripheral neuropathy termed Charcot-Marie-Tooth disease type 1C (CMT1C), but the pathogenic mechanisms of these mutations remain unknown...
  2. Polyak K, Xia Y, Zweier J, Kinzler K, Vogelstein B. A model for p53-induced apoptosis. Nature. 1997;389:300-5 pubmed
    ....
  3. Tang X, Fenton M, Amar S. Identification and functional characterization of a novel binding site on TNF-alpha promoter. Proc Natl Acad Sci U S A. 2003;100:4096-101 pubmed
    ..Previously, a transcription factor, termed lipopolysaccharide-induced TNF-alpha factor (LITAF), was found to regulate TNF-alpha gene expression...
  4. Lacerda A, Hartjes E, Brunetti C. LITAF mutations associated with Charcot-Marie-Tooth disease 1C show mislocalization from the late endosome/lysosome to the mitochondria. PLoS ONE. 2014;9:e103454 pubmed publisher
    ..Mutations in LITAF have been shown to be causative for CMT type 1C disease...
  5. Latour P, Gonnaud P, Ollagnon E, Chan V, Perelman S, Stojkovic T, et al. SIMPLE mutation analysis in dominant demyelinating Charcot-Marie-Tooth disease: three novel mutations. J Peripher Nerv Syst. 2006;11:148-55 pubmed
    ..type 1C (CMT1C) is caused by mutations in the small integral membrane protein of the lysosome/late endosome (SIMPLE)...
  6. Beauvais K, Furby A, Latour P. Clinical, electrophysiological and molecular genetic studies in a family with X-linked dominant Charcot-Marie-Tooth neuropathy presenting a novel mutation in GJB1 Promoter and a rare polymorphism in LITAF/SIMPLE. Neuromuscul Disord. 2006;16:14-8 pubmed
    ..of Charcot-Marie-Tooth disease with dominant inheritance, five genes have been incriminated: PMP22, MPZ, LITAF/SIMPLE, EGR2 (CMT1A to D), and GJB1 (CMTX)...
  7. Saifi G, Szigeti K, Wiszniewski W, Shy M, Krajewski K, Hausmanowa Petrusewicz I, et al. SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation. Hum Mutat. 2005;25:372-83 pubmed
    ..Recently, SIMPLE/LITAF was shown to be responsible for an autosomal dominant demyelinating form of CMT linked to 16p (CMT1C)...
  8. Myokai F, Takashiba S, Lebo R, Amar S. A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment. Proc Natl Acad Sci U S A. 1999;96:4518-23 pubmed
    ..that its induction was dependent on LPS activation of THP-1 cells; hence, the name LPS-induced TNF-alpha factor (LITAF). Inhibition of LITAF mRNA expression in THP-1 cells resulted in a reduction of TNF-alpha transcripts...
  9. Bennett C, Shirk A, Huynh H, Street V, Nelis E, Van Maldergem L, et al. SIMPLE mutation in demyelinating neuropathy and distribution in sciatic nerve. Ann Neurol. 2004;55:713-20 pubmed
    ..neuropathy caused by missense mutations in the small integral membrane protein of lysosome/late endosome (SIMPLE) gene...
  10. Ludes Meyers J, Kil H, Bednarek A, Drake J, Bedford M, Aldaz C. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene. 2004;23:5049-55 pubmed
    ..The binding to one of these candidates, small membrane protein of the lysosome/late endosome (SIMPLE), was further analysed, and we observed that a specific PPSY motif in the SIMPLE amino-acid sequence was required ..
  11. Jolliffe C, Harvey K, Haines B, Parasivam G, Kumar S. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Biochem J. 2000;351 Pt 3:557-65 pubmed
    ..These results provide evidence that Nedd4 can potentially interact with multiple proteins, possibly simultaneously, through its WW domains. ..
  12. Meggouh F, de Visser M, Arts W, De Coo R, van Schaik I, Baas F. Early onset neuropathy in a compound form of Charcot-Marie-Tooth disease. Ann Neurol. 2005;57:589-91 pubmed
    ..22 (PMP22) duplication and a mutation in the lipopolysaccharide-induced-tumour-necrosis-factor-alpha-factor (LITAF) gene, whereas each parent only had one mutated CMT gene...
  13. Tang X, Marciano D, Leeman S, Amar S. LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. Proc Natl Acad Sci U S A. 2005;102:5132-7 pubmed
    ..Previously, we identified a transcription factor, LPS-induced TNF-alpha factor (LITAF), that regulates TNF-alpha transcription...
  14. Shirk A, Anderson S, Hashemi S, Chance P, Bennett C. SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease. J Neurosci Res. 2005;82:43-50 pubmed
    Mutation of the SIMPLE gene (small integral membrane protein of the lysosome/late endosome) is the molecular basis of Charcot-Marie-Tooth disease type 1C (CMT1C), a demyelinating peripheral neuropathy...
  15. Street V, Bennett C, Goldy J, Shirk A, Kleopa K, Tempel B, et al. Mutation of a putative protein degradation gene LITAF/SIMPLE in Charcot-Marie-Tooth disease 1C. Neurology. 2003;60:22-6 pubmed
    ..LITAF, which is also referred to as SIMPLE, is a widely expressed gene encoding a 161-amino acid protein that may play a role in protein degradation pathways...
  16. Stucchi A, Reed K, O Brien M, Cerda S, Andrews C, Gower A, et al. A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Inflamm Bowel Dis. 2006;12:581-7 pubmed
    ..Recently, a new transcription factor termed LITAF (lipopolysaccharide-induced TNF-alpha factor) was shown to mediate TNF-alpha expression in human macrophages by ..
  17. Eaton H, Desrochers G, Drory S, Metcalf J, Angers A, Brunetti C. SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments. PLoS ONE. 2011;6:e16873 pubmed publisher
    ..The C-terminus of LITAF contains a highly conserved domain termed the SIMPLE-like domain (SLD), while the N-terminus contains two PPXY motifs that mediate protein-protein interactions with WW-..
  18. Zhu H, Guariglia S, Yu R, Li W, Brancho D, Peinado H, et al. Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes. Mol Biol Cell. 2013;24:1619-37, S1-3 pubmed publisher
    ..Mutations in the small integral membrane protein of the lysosome/late endosome (SIMPLE) account for the rare autosomal-dominant demyelination in CMT1C patients...
  19. Moriwaki Y, Begum N, Kobayashi M, Matsumoto M, Toyoshima K, Seya T. Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1. J Biol Chem. 2001;276:23065-76 pubmed
    ..this novel protein as an unglycosylated small integral membrane protein of the lysosome/late endosome (SIMPLE) whose expression is elicited in monocytes by live and heat-killed BCG, BCG cell wall complex, lipopolysaccharide, ..
  20. Lee S, Chin L, Li L. Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking. J Cell Biol. 2012;199:799-816 pubmed publisher
    Mutations in small integral membrane protein of lysosome/late endosome (SIMPLE) cause autosomal dominant, Charcot-Marie-Tooth disease (CMT) type 1C...
  21. Balaz P, Rokosny S, Klein D, Adamec M. Aneurysmorrhaphy is an easy technique for arteriovenous fistula salvage. J Vasc Access. 2008;9:81-4 pubmed
    ..This paper describes a simple and inexpensive technique of managing an AVF pseudoaneurysm, i.e. aneurysmorrhaphy...
  22. Planz V, Wang J, Windbergs M. Establishment of a cell-based wound healing assay for bio-relevant testing of wound therapeutics. J Pharmacol Toxicol Methods. 2018;89:19-25 pubmed publisher
    ..b>Simple "scratch tests" based on defected skin cell monolayers exist, however these can solely be used for testing liquids,..
  23. Kortyna A, Samin A, Miller T, Nesbitt D. Sub-Doppler infrared spectroscopy of resonance-stabilized hydrocarbon intermediates: ν3/ν4 CH stretch modes and CH2 internal rotor dynamics of benzyl radical. Phys Chem Chem Phys. 2017;19:29812-29821 pubmed publisher
    ..In summary, the high-resolution infrared spectra are in excellent agreement with simple physical organic chemistry pictures of a strongly resonance-stabilized benzyl radical with a nearly rigid planar ..
  24. Inomura K, Bragg J, Follows M. A quantitative analysis of the direct and indirect costs of nitrogen fixation: a model based on Azotobacter vinelandii. ISME J. 2017;11:166-175 pubmed publisher
    ..The latter mechanisms lead to higher growth efficiencies relative to respiratory protection alone. This simple, yet mechanistic framework provides a quantitative model of nitrogen fixation, which can be applied in ecological ..
  25. Silvestri A, Cistrone P, Dawson P. Adapting the Glaser Reaction for Bioconjugation: Robust Access to Structurally Simple, Rigid Linkers. Angew Chem Int Ed Engl. 2017;56:10438-10442 pubmed publisher
    ..The generality of this method is illustrated through the conjugation of a series of polar and nonpolar labels onto a fully unprotected GLP-1R agonist through a linear 7 Å diynyl linker...
  26. Opazo Navarrete M, Schutyser M, Boom R, Janssen A. Effect of pre-treatment on in vitro gastric digestion of quinoa protein (Chenopodium quinoa Willd.) obtained by wet and dry fractionation. Int J Food Sci Nutr. 2018;69:1-11 pubmed publisher
    ..05) digestibility than QPI samples. The results were interpreted with a simple double exponential model. The fraction of easily digested protein in QPC is higher than for QPI...
  27. Luo Q, Cao F, Xiong C, Dou Q, Qu D. Hybrid cis/trans Tetra-arylethenes with Switchable Aggregation-Induced Emission (AIE) and Reversible Photochromism in the Solution, PMMA Film, Solid Powder, and Single Crystal. J Org Chem. 2017;82:10960-10967 pubmed publisher
    ..In this presentation, we devote to constructing a kind of simple structures with composite functionalities through straightforward preparation...
  28. Siddiq M, Hochberg G, Thornton J. Evolution of protein specificity: insights from ancestral protein reconstruction. Curr Opin Struct Biol. 2017;47:113-122 pubmed publisher
    ..Further, the new specific interactions evolved by simple mechanisms, with just a few mutations changing classically recognized biochemical determinants of specificity, ..
  29. Chen J, Penn L, Xi J. Quartz crystal microbalance: Sensing cell-substrate adhesion and beyond. Biosens Bioelectron. 2018;99:593-602 pubmed publisher
    ..crystal microbalance (QCM) is a label-free, biosensing system that has, in the past fifty years, evolved from a simple acoustic based mass sensor to a powerful bioanalytical tool...
  30. Haußmann A. Light scattering from sessile water drops and raindrop-shaped glass beads as a validation tool for rainbow simulations. Appl Opt. 2017;56:G136-G144 pubmed publisher
    ..To check the accuracy of numerical optical models for rainbow scattering from such nonspherical drops, two simple and low-cost experiments are presented in this paper: (1) sessile, i.e...
  31. Zhang H, Zhao X, Liu S, Yang J, Duan R, Yuan Y, et al. Determination of Sunset Yellow Based on Its Quenching Effect on the Fluorescence of Acridine Orange. Anal Sci. 2017;33:243-247 pubmed publisher
    ..008 - 9.0 μmol L-1. Herein, this finding was utilized to develop a new strategy for simple, rapid, sensitive and selective detection of SY by combining AO based on fluorescence quenching...
  32. Pan A, Jurow M, Zhao Y, Qiu F, Liu Y, Yang J, et al. Templated self-assembly of one-dimensional CsPbX3 perovskite nanocrystal superlattices. Nanoscale. 2017;9:17688-17693 pubmed publisher
    ..Here we investigated a simple kinetic approach to form self-assembled one-dimensional perovskite CsPbX3 (X: halides) nanocrystal ..
  33. Diner I, Nguyen T, Seyfried N. Enrichment of Detergent-insoluble Protein Aggregates from Human Postmortem Brain. J Vis Exp. 2017;: pubmed publisher
    ..Thus, this simple enrichment protocol is ideal for a wide range of experimental applications ranging from Western blotting and ..
  34. Delesma F, Van den Bossche M, Grönbeck H, Calaminici P, Koster A, Pettersson L. A Chemical View on X-ray Photoelectron Spectroscopy: the ESCA molecule and surface-to-bulk XPS shifts. Chemphyschem. 2017;: pubmed publisher
    In this paper we remind the reader of a simple, intuitive picture of chemical shifts in x-ray photoelectron spectroscopy (XPS) as the difference in chemical bonding between the probed atom and its neighbor to the right in the periodic ..
  35. Hatfield M, Reilhac C, Cowley H, Chang E, McCloskey M. Cognitive processes in spatial mapping: Evidence from a developmental spatial deficit. Cogn Neuropsychol. 2017;:1-18 pubmed publisher
    ..K.Y.) with a developmental deficit affecting spatial processing. In a simple spatial mapping task, N.K.Y...
  36. Auslender I, Barmashenko B, Rosenwaks S. Multi-transverse mode operation of alkali vapor lasers: modeling and comparison with experiments. Opt Express. 2017;25:19767-19779 pubmed publisher
    ..A simple optical model of multi-transverse mode operation of alkali vapor lasers is reported...
  37. Korobko D, Fotiadi A, Zolotovskii I. Mode-locking evolution in ring fiber lasers with tunable repetition rate. Opt Express. 2017;25:21180-21190 pubmed publisher
    We have applied a simple approach to analyze behavior of the harmonically mode-locked fiber laser incorporating an adjustable Mach-Zehnder interferometer (MZI)...
  38. Ch ng S, Andriyana A, Tee Y, Verron E. Effects of Carbon Black and the Presence of Static Mechanical Strain on the Swelling of Elastomers in Solvent. Materials (Basel). 2015;8:884-898 pubmed publisher
    ..of carbon black content on the swelling of elastomers in solvent in the presence of static mechanical strains: simple extension and simple torsion...
  39. Foroutan T, Nazemi N, Tavana M, Kassaee M, Motamedi E, Soieshargh S, et al. Suspended graphene oxide nanoparticle for accelerated multilayer osteoblast attachment. J Biomed Mater Res A. 2018;106:293-303 pubmed publisher
    ..In this study, we proposed a simple technique for assembly of cells that facilitates the construction of osteoblast-like structures using suspended GO ..
  40. Aghaeepour N, Kin C, Ganio E, Jensen K, Gaudilliere D, Tingle M, et al. Deep Immune Profiling of an Arginine-Enriched Nutritional Intervention in Patients Undergoing Surgery. J Immunol. 2017;: pubmed publisher
    ..framework to distill high-dimensional datasets gathered in an interventional clinical trial into a fairly simple model that converges with known biology and provides insight into novel and clinically relevant cellular ..
  41. Cheng Y, Zhang P, Jia Y, Fang Z, Li P. Organocatalytic condensation-ring opening-annulation cascade reactions between N-Bocindolin-2-ones/benzofuran-2(3H)-ones and salicylaldehydes for synthesis of 3-arylcoumarins. Org Biomol Chem. 2017;15:7505-7508 pubmed publisher
    ..This method was featured by a broad scope of reactants, mild conditions, and simple operation.
  42. Mesquita A, Cardenal Muñoz E, Dominguez E, Muñoz Braceras S, Núñez Corcuera B, Phillips B, et al. Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model. Autophagy. 2017;13:24-40 pubmed publisher
    ..Understanding the complexity of the mechanism and regulation of this process often benefits from the use of simple experimental models such as the social amoeba Dictyostelium discoideum...
  43. Johnson J, Michl J. 1,3-Diphenylisobenzofuran: a Model Chromophore for Singlet Fission. Top Curr Chem (Cham). 2017;375:80 pubmed publisher
    ..In the last section we present the operation of a simple device illustrating the use of triplets generated by singlet fission for charge separation.
  44. Feng X, Xiang P, Chen H, Shen M. LC-MS-MS with Post-Column Reagent Addition for the Determination of Zolpidem and its Metabolite Zolpidem Phenyl-4-carboxylic Acid in Oral Fluid after a Single Dose. J Anal Toxicol. 2017;:1-9 pubmed publisher
    ..Preliminary sample treatment was limited to a simple dilution of 1 mL oral fluid specimen aliquots with methanol...
  45. Thomas K, Marsiske M. Age trajectories of everyday cognition in African American and White older adults under prompted and unprompted conditions. Neuropsychol Rehabil. 2017;27:522-539 pubmed publisher
    ..b>Simple prompting attenuated age-related changes of African Americans and Whites on a measure of everyday cognition...
  46. Gil Rubio J, Vicente J. The Coordination and Supramolecular Chemistry of Gold Metalloligands. Chemistry. 2017;: pubmed publisher
    ..The reported heterometallic species range from simple dinuclear complexes to self-assembled supramolecules, coordination polymers, or solids...
  47. Gruss D, Smolyanitsky A, Zwolak M. Communication: Relaxation-limited electronic currents in extended reservoir simulations. J Chem Phys. 2017;147:141102 pubmed publisher
    ..findings yield a physically motivated approach to diagnosing numerical simulations and understanding the influence of relaxation, and we examine their occurrence in both simple models and a realistic, fluctuating graphene nanoribbon.
  48. Keane A, Krauskopf B, Postlethwaite C. Climate models with delay differential equations. Chaos. 2017;27:114309 pubmed publisher
    ..is to find a model that embodies the essential underlying physics of a system, while at the same time being simple enough to allow for mathematical analysis...
  49. Garabon J, Higgs D. The effects of stimulus parameters on auditory evoked potentials of Carassius auratus. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017;203:945-951 pubmed publisher
    ..The effect of varying parameters is especially unclear in fish studies, the majority of which use simple sound types and then extrapolate to natural conditions...
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    ..The health technology assessment body critically evaluates reimbursement submissions of pharmaceuticals, simple medical devices, and complex medical devices such as hospital technologies.
  51. Ordoukhanian P, Nichols J, Head S. Primer Extension, Capture, and On-Bead cDNA Ligation: An Efficient RNAseq Library Prep Method for Determining Reverse Transcription Termination Sites. Methods Mol Biol. 2018;1712:253-261 pubmed publisher
    ..The utilization of solid-phase bead chemistries facilitates simple workflow and efficient library yields.
  52. Massoud E, Huisman J, Benincà E, Dietze M, Bouten W, Vrugt J. Probing the limits of predictability: data assimilation of chaotic dynamics in complex food webs. Ecol Lett. 2017;: pubmed publisher
    ..to predict accurately population dynamics, and benchmark our population model's forecast horizon against a simple null model...
  53. Wang C, Zhang P, Jin W, Li L, Qiang S, Zhang Y, et al. Quantitative O-glycomics based on improvement of the one-pot method for nonreductive O-glycan release and simultaneous stable isotope labeling with 1-(d0/d5)phenyl-3-methyl-5-pyrazolone followed by mass spectrometric analysis. J Proteomics. 2017;150:18-30 pubmed publisher
    Rapid, simple and versatile methods for quantitative analysis of glycoprotein O-glycans are urgently required for current studies on protein O-glycosylation patterns and the search for disease O-glycan biomarkers...
  54. Sun Y, Chen J, Li J, Xu Y, Jin H, Xu N, et al. Novel approach based on one-tube nested PCR and a lateral flow strip for highly sensitive diagnosis of tuberculous meningitis. PLoS ONE. 2017;12:e0186985 pubmed publisher
    ..This one-tube nested PCR-lateral flow strip assay is useful for detecting M. tuberculosis in TBM due to its rapidity, high sensitivity and simple manipulation.
  55. Ha J, Kim H, Moon K, Jeon J, Jung D, Kim S, et al. Recombinant Human Acidic Fibroblast Growth Factor (aFGF) Expressed in Nicotiana benthamiana Potentially Inhibits Skin Photoaging. Planta Med. 2017;83:862-869 pubmed publisher
    ..Up to 10 µg recombinant human-acidic fibroblast growth factor/g of fresh leaves were achieved by a simple affinity purification protocol using protein extract from the leaves of agroinfiltrated N. benthamiana...
  56. Porfirev A, Khonina S. Simple method for efficient reconfigurable optical vortex beam splitting. Opt Express. 2017;25:18722-18735 pubmed publisher
    ....
  57. Khokhar N, Park J. A simplified sampling procedure for the estimation of methane emission in rice fields. Environ Monit Assess. 2017;189:468 pubmed publisher
    ..This new sampling scheme is simple and more efficient than current sampling practices...
  58. Mandsberg N, Hansen O, Taboryski R. Generation of micro-droplet arrays by dip-coating of biphilic surfaces; the dependence of entrained droplet volume on withdrawal velocity. Sci Rep. 2017;7:12794 pubmed publisher
    ..A simple 2D boundary layer model describes the behavior at high speeds well...
  59. Broxterman R, Trinity J, Gifford J, Kwon O, Kithas A, Hydren J, et al. Single passive leg movement assessment of vascular function: The contribution of nitric oxide. J Appl Physiol (1985). 2017;:jap.00533.2017 pubmed publisher
    ..As such, sPLM appears to be a promising, simple, in vivo assessment of NO-mediated vascular function and NO bioavailability.
  60. Chen H, Yang Y, Jiang W, Song M, Wang Y, Xiang T. Source separation of municipal solid waste: The effects of different separation methods and citizens' inclination-case study of Changsha, China. J Air Waste Manag Assoc. 2017;67:182-195 pubmed publisher
    ..For the effects of separation methods, the site experiment result demonstrates that the relatively simple separation method involving two categories (food waste and other waste) achieves the best effect with the highest ..
  61. Zeng H, Li L, Ding Y, Zhuang Q. Simple and selective determination of 6-thioguanine by using polyethylenimine (PEI) functionalized carbon dots. Talanta. 2018;178:879-885 pubmed publisher
    In this work, a new selective and simple fluorescence probe based on polyethylenimine(PEI) functionalized carbon dots (PEI-CDs) for fast determination of 6-thioguanine (6-TG) was developed...
  62. Lim H, Seo K, Yoon M, Yang H, Tahk S. Ischemia-based Coronary Revascularization: Beyond Anatomy and Fractional Flow Reserve. Korean Circ J. 2018;48:16-23 pubmed publisher
    ..for coronary stenosis, there is considerable discordance between the 2 modalities, and the diagnostic accuracy of simple parameters obtained from current imaging tools is not satisfactory to determine functional significance...