MAP1A

Summary

Gene Symbol: MAP1A
Description: microtubule associated protein 1A
Alias: MAP1L, MTAP1A, microtubule-associated protein 1A, MAP-1A, proliferation-related protein p80
Species: human

Top Publications

  1. ncbi Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15
    R Fukuyama
    Laboratory of Neurosciences, NIA, NIH, Bethesda, MD 20892, USA
    J Neurosci Res 40:820-5. 1995
  2. ncbi Regulation of microtubule-associated protein 1B (MAP1B) subunit composition
    X Mei
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci Res 62:56-64. 2000
  3. ncbi The functional cooperation of MAP1A heavy chain and light chain 2 in the binding of microtubules
    Chung Liang Chien
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, 100, Taiwan
    Exp Cell Res 308:446-58. 2005
  4. pmc The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain
    Maria Eriksson
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, 141 86 Stockholm, Sweden
    Biochem Biophys Res Commun 361:127-32. 2007
  5. doi Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice
    M Shiozaki
    Laboratory of Cell Biology, College of Nutrition, Koshien University, 10 1 Momijigaoka, Takarazuka, Hyogo 665 0006, Japan
    Neuroscience 152:924-41. 2008
  6. pmc Functional and developmental impact of cytosolic protein N-terminal methionine excision in Arabidopsis
    Simon Ross
    Protein Maturation Group, Institut des Sciences du Vegetal, Unité Propre de Recherche 2355, Centre National de la Recherche Scientifique, F 91198 Gif sur Yvette Cedex, France
    Plant Physiol 137:623-37. 2005
  7. ncbi Microtubule associated protein (MAP1A) mRNA was up-regulated by hypergravity in the rat inner ear
    Yutaka Takumi
    Department of Otorhinolaryngology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Brain Res Mol Brain Res 108:139-42. 2002
  8. ncbi Changes of cytoskeletal protein immunostaining in myelinated fibre tracts after focal cerebral ischaemia in the rat
    D Dewar
    Wellcome Surgical Institute, University of Glasgow, UK
    Acta Neuropathol 93:71-7. 1997
  9. ncbi Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins
    Constanze I Seidenbecher
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestr 6 39118 Magdeburg, Germany
    J Mol Biol 336:957-70. 2004
  10. ncbi Nuclear export factor family protein participates in cytoplasmic mRNA trafficking
    Irina Tretyakova
    Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 280:31981-90. 2005

Research Grants

  1. MAP1A AND MAP1B--SYNTHESIS, STRUCTURE/FUNCTION
    JAMES HAMMARBACK; Fiscal Year: 2000
  2. Tau phosphorylation and neurodegeneration
    Alejandra del C Alonso; Fiscal Year: 2009

Scientific Experts

  • Isabelle Lajoie-Mazenc
  • Elliott M Faller
  • Nicholas J Hudson
  • Noriko Murakami
  • Chung Liang Chien
  • K Iqbal
  • Fuyuki Mitsuyama
  • Yuko Yasuda
  • Gregory H Grossman
  • Leif Dehmelt
  • N Ulfig
  • M Oudega
  • Deborah Dewar
  • K R Johnson
  • B Hutter-Paier
  • Hiromichi Matsumoto
  • A Johansson
  • Giovanni Stevanin
  • Leyuan Liu
  • Alejandra del C Alonso
  • JAMES HAMMARBACK
  • Friedrich Propst
  • Rainer Noiges
  • Avi Gadoth
  • Wallace L McKeehan
  • John D Eicher
  • Radouil Tzekov
  • Fei Yue
  • Tao Wu
  • Jing Zou
  • Kun Song
  • Jianguo Zhu
  • Ye Liu
  • Yosuke Takei
  • Xianhan Jiang
  • Juliette Fernandez
  • Bhavani S Kowtharapu
  • Michael A Meyer
  • Qiu Lan Ma
  • Akihiro Ikeda
  • Fen Wang
  • Vanja Duric
  • Fatiha Nothias
  • Philip Long
  • Mona Gupta
  • Erika Elgstrand Wettergren
  • Christopher A Johnston
  • Dennis M Maddox
  • Prisiliana Velázquez-Bernardino
  • Heike Fuhrmann-Stroissnigg
  • Ana M Ruiz-Muñoz
  • Rui Xie
  • Rachel A Myers
  • Qing Fang
  • Lihai Zhang
  • Jeremy H Herskowitz
  • Kouroush Sadegh Zadeh
  • Hugo H Hanson
  • Sung Jin An
  • Liisa Tomppo
  • Jeong Woong Lee
  • J Avila
  • M Shiozaki
  • Beiyan Zou
  • A G Miriam Leenders
  • Michael L Reese
  • Maria Eriksson
  • Irmgard Fischer
  • Jurgen K Naggert
  • Chihiro Kakiuchi
  • Patsy M Nishina
  • Douglas J Sheffler
  • Shelley Halpain
  • M Leszczyniecka
  • David M Longhurst
  • Alzbeta Trancikova
  • Györgyi Szebenyi
  • Irina Tretyakova
  • Simon Ross
  • David S Bredt
  • Zsuzsanna Orbán-Németh
  • Sonja Wolff
  • Stephen J Yarwood
  • J A Hammarback
  • Niloufar Haque
  • Constanze I Seidenbecher
  • F Touri
  • Maria M Magiera
  • Rene Eichinger
  • Tijs Ketelaar

Detail Information

Publications110 found, 100 shown here

  1. ncbi Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15
    R Fukuyama
    Laboratory of Neurosciences, NIA, NIH, Bethesda, MD 20892, USA
    J Neurosci Res 40:820-5. 1995
    ..A 1,570 bp sequence of one cDNA fragment showed 75% homology to the rat microtubule-associated protein 1A (MAP1A) cDNA sequence...
  2. ncbi Regulation of microtubule-associated protein 1B (MAP1B) subunit composition
    X Mei
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci Res 62:56-64. 2000
    The MAP1B and MAP1A genes each produce an mRNA that encodes a polyprotein. When cleaved, each polyprotein yields a single heavy chain and a single light chain, which become noncovalently associated...
  3. ncbi The functional cooperation of MAP1A heavy chain and light chain 2 in the binding of microtubules
    Chung Liang Chien
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei, 100, Taiwan
    Exp Cell Res 308:446-58. 2005
    Microtubule-associated protein 1A (MAP1A) is a high-molecular-weight protein that is comprised of a heavy chain and a light chain (LC2) and is widely distributed along the microtubules in both mature neurons and glial cells...
  4. pmc The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain
    Maria Eriksson
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, 141 86 Stockholm, Sweden
    Biochem Biophys Res Commun 361:127-32. 2007
    ..MAP1S belongs to the same family as MAP1A and MAP1B, and was found to be abundant in both postnatal and adult rat brain...
  5. doi Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice
    M Shiozaki
    Laboratory of Cell Biology, College of Nutrition, Koshien University, 10 1 Momijigaoka, Takarazuka, Hyogo 665 0006, Japan
    Neuroscience 152:924-41. 2008
    ..Neuronal cellular organelles were morphologically disordered. Lysosomes, cathepsin D and light chain 3 of MAP1A/B (LC3) were augmented with the appearance of putative autophagy-related structures...
  6. pmc Functional and developmental impact of cytosolic protein N-terminal methionine excision in Arabidopsis
    Simon Ross
    Protein Maturation Group, Institut des Sciences du Vegetal, Unité Propre de Recherche 2355, Centre National de la Recherche Scientifique, F 91198 Gif sur Yvette Cedex, France
    Plant Physiol 137:623-37. 2005
    ..Three enzymes, MAP1A, MAP2A, and MAP2B, have been identified in the cytoplasm of Arabidopsis (Arabidopsis thaliana)...
  7. ncbi Microtubule associated protein (MAP1A) mRNA was up-regulated by hypergravity in the rat inner ear
    Yutaka Takumi
    Department of Otorhinolaryngology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Brain Res Mol Brain Res 108:139-42. 2002
    ..The up-regulation of microtubule associated protein 1A (MAP1A) in one of these was confirmed by real-time polymerase chain reaction...
  8. ncbi Changes of cytoskeletal protein immunostaining in myelinated fibre tracts after focal cerebral ischaemia in the rat
    D Dewar
    Wellcome Surgical Institute, University of Glasgow, UK
    Acta Neuropathol 93:71-7. 1997
    ..The purpose of the present study was to examine immunostaining of beta-tubulin, MAP1a and MAP5, all of which are located in axons as well as perikarya, specifically in myelinated fibre tracts in rats ..
  9. ncbi Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins
    Constanze I Seidenbecher
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestr 6 39118 Magdeburg, Germany
    J Mol Biol 336:957-70. 2004
    ..These findings provide molecular evidence that NCS can transduce signals to a specific target interaction irrespective of Ca(2+)-concentrations and CaM-levels...
  10. ncbi Nuclear export factor family protein participates in cytoplasmic mRNA trafficking
    Irina Tretyakova
    Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 280:31981-90. 2005
    ..We propose a model in which MAP1B tethers the NXF-associated mRNA to microtubules and facilitates their translocation along dendrites while Unrip provides a scaffold for the assembly of these transport intermediates...
  11. ncbi Amyloid beta: a putative intra-spinal microtubule-depolymerizer to induce synapse-loss or dentritic spine shortening in Alzheimer's disease
    Fuyuki Mitsuyama
    Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan
    Ital J Anat Embryol 114:109-20. 2009
    ..present in the axon, but hyperphosphorylated tau newly distributes to the dendrites and sequesters normal tau, MAP1A/MAP1B and MAP2, and may cause disruption of intraspinal microtubules by losing the microtubule-preserving effect ..
  12. pmc Phosphorylation by Dyrk1A of clathrin coated vesicle-associated proteins: identification of the substrate proteins and the effects of phosphorylation
    Noriko Murakami
    Laboratory of Molecular Regulation, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America gov
    PLoS ONE 7:e34845. 2012
    ..Mass spectrometric analysis identified MAP1A, MAP2, AP180, and α- and β-adaptins as the phosphorylated proteins in the CCVs...
  13. pmc Sensory rewiring in an echolocator: genome-wide modification of retinogenic and auditory genes in the bat Myotis davidii
    Nicholas J Hudson
    Computational and Systems Biology, CSIRO Agriculture Flagship, Queensland Bioscience Precinct, Brisbane, Queensland, Australia
    G3 (Bethesda) 4:1825-35. 2014
    ..CRX, SOX8, VAX2, HPS1, RHO, PRPH2, and SOX9) and hearing-related (TPRN, TMIE, SLC52A3, OTOF, WFS1, SOD1, TBX18, MAP1A, OTOS, GPX1, and USH1G) machinery in M. davidii but not P. alecto...
  14. pmc Sub-Chronic Neuropathological and Biochemical Changes in Mouse Visual System after Repetitive Mild Traumatic Brain Injury
    Radouil Tzekov
    The Roskamp Institute, Sarasota, FL, United States of America
    PLoS ONE 11:e0153608. 2016
    ..proteins, including neurofilaments (NEFH, NEFM, NEFL), tubulin (TUBB2A, TUBA4A), microtubule-associated proteins (MAP1A, MAP1B), collagen (COL6A1, COL6A3) and increased expression of other proteins, including heat shock proteins (..
  15. ncbi Microtubule-associated proteins 1A and LC2. Two proteins encoded in one messenger RNA
    A Langkopf
    Center for Molecular Neurobiology, University of Hamburg, Germany
    J Biol Chem 267:16561-6. 1992
    ..Though previously described as biochemically and immunologically distinct from MAP1B, we now demonstrate that MAP1A is structurally related to MAP1B, a protein associated with neurite outgrowth and process plasticity...
  16. pmc Neuronal abnormalities in microtubule-associated protein 1B mutant mice
    W Edelmann
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 93:1270-5. 1996
    ..Purkinje cell dendritic processes are abnormal, do not react with MAP1B antibodies, and show reduced staining with MAP1A antibodies...
  17. pmc Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain
    M Tögel
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, A 1030 Vienna, Austria
    J Cell Biol 143:695-707. 1998
    ..we localized the domains for heavy chain-light chain interaction to regions containing sequences homologous to MAP1A. Our findings assign several crucial activities to the MAP1B light chain and suggest a new model for the mechanism ..
  18. ncbi Effects of NaCN and ionomycin on neuronal viability and on the abundance of microtubule-associated proteins MAP1, MAP2, and tau in isolated chick cortical neurons
    B Hutter-Paier
    Institute of Experimental Pharmacology, JSW Research, Graz, Austria
    Cell Tissue Res 302:39-47. 2000
    ..after extended recovery from NaCN lesion protein expression was normalizing (MAP2) or at least still detectable (MAP1A, tau), the consequences of a permanent IM lesion were more severe, since neurons were not able to maintain or even ..
  19. ncbi Accumulation of microtubule-associated proteins in the hippocampal neurons of seizure-sensitive gerbils
    Sung Jin An
    Department of Anatomy, College of Medicine, Hallym University, Chunchon 200 702, Korea
    Mol Cells 15:200-7. 2003
    We have carried out a chronological and comparative analysis of microtubule-associated protein 1A (MAP1A) and microtubule-associated protein 2 (MAP2) immunoreactivities in the hippocampi of seizure-resistant (SR) and seizure-sensitive (..
  20. ncbi Arabidopsis homologues of the autophagy protein Atg8 are a novel family of microtubule binding proteins
    Tijs Ketelaar
    The Integrative Cell Biology Laboratory, School of Biological and Biomedical Sciences, University of Durham, South Road, Durham DH1 3LE, UK
    FEBS Lett 567:302-6. 2004
    ..Interestingly, Atg8 shows significant homology with the microtubule binding light chain 3 of MAP1A and B, and here we show that Arabidopsis Atg8 binds microtubules...
  21. ncbi Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells
    Niloufar Haque
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Brain Res Mol Brain Res 129:163-70. 2004
    ..We found that the expression of MAP1b in addition to tau was upregulated upon differentiation. Tau, MAP1a, MAP1b and MAP2 had distinct immunocytochemical staining patterns in differentiated SY5Y cells, suggesting ..
  22. pmc Distinct structural domains within C19ORF5 support association with stabilized microtubules and mitochondrial aggregation and genome destruction
    Leyuan Liu
    Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Cancer Res 65:4191-201. 2005
    C19ORF5 is a sequence homologue of microtubule-associated proteins MAP1A/MAP1B of unknown function, except for its association with mitochondria-associated proteins and the paclitaxel-like microtubule stabilizer and candidate tumor ..
  23. pmc Strain background effects and genetic modifiers of hearing in mice
    Kenneth R Johnson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Brain Res 1091:79-88. 2006
    ..The hearing modifier (Moth1) of tubby (Tub(tub)) mutant mice was shown to be a strain variant of the Mtap1a gene...
  24. pmc The light chains of microtubule-associated proteins MAP1A and MAP1B interact with α1-syntrophin in the central and peripheral nervous system
    Heike Fuhrmann-Stroissnigg
    Max F Perutz Laboratories, University of Vienna, Department of Biochemistry and Cell Biology, Vienna, Austria
    PLoS ONE 7:e49722. 2012
    Microtubule-associated proteins of the MAP1 family (MAP1A, MAP1B, and MAP1S) share, among other features, a highly conserved COOH-terminal domain approximately 125 amino acids in length...
  25. doi Interaction of tubby-like protein-1 (Tulp1) and microtubule-associated protein (MAP) 1A and MAP1B in the mouse retina
    Gregory H Grossman
    Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA
    Adv Exp Med Biol 801:511-8. 2014
    ..An allele of Mtap1a, which encodes the MAP1A protein, significantly delays photoreceptor degeneration in Tulp1 mutant mice...
  26. pmc Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging
    Qiu Lan Ma
    Department of Neurology, University of California, Los Angeles, California 90095, Geriatric Research, Education and Clinical Center, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 90073
    J Neurosci 34:7124-36. 2014
    ..Deletion of tau, a microtubule-associated protein (MAP), resulted in increased levels of MAP1A, MAP1B, and MAP2 in MKO, followed by loss of MAP2 and MAP1B in OKO...
  27. doi Corneal epithelial and neuronal interactions: role in wound healing
    Bhavani S Kowtharapu
    Department of Opthalmology, University of Rostock, Doberaner Strasse 140, 18057 Rostock, Germany Electronic address
    Exp Eye Res 125:53-61. 2014
    ..Neurite outgrowth assay and RT-PCR analysis using primers specific for substance P (SP), Map1a, Map1b were performed on trigeminal neurons in the presence of CEM...
  28. pmc Highly expressed genes in human high grade gliomas: immunohistochemical analysis of data from the human protein atlas
    Michael A Meyer
    Department of Neurology, Sisters Hospital, Buffalo, NY, USA
    Neurol Int 6:5348. 2014
    ..are: AGBL2 (ATP/GTP binding protein-like 2), BLOC1S6 (biogenesis of lysosomal organelles complex-1, subunit 6), MAP1A (microtubule-associated protein 1A) and ZSWIM5 (zinc finger, SWIM-type containing 5, also known as KIAA1511)...
  29. pmc Autophagy defects suggested by low levels of autophagy activator MAP1S and high levels of autophagy inhibitor LRPPRC predict poor prognosis of prostate cancer patients
    Xianhan Jiang
    Department of Urology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China
    Mol Carcinog 54:1194-204. 2015
    MAP1S (originally named C19ORF5) is a widely distributed homolog of neuronal-specific MAP1A and MAP1B, and bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation...
  30. pmc Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus
    Juliette Fernandez
    From INSERM U941, Institut Universitaire d Hématologie de l Hôpital Saint Louis, 75010 Paris, France
    J Biol Chem 290:4631-46. 2015
    ..screen, we identified four cytoskeletal components as putative interaction partners for HIV-1 p24 capsid protein: MAP1A, MAP1S, CKAP1, and WIRE...
  31. pmc Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration
    Ye Liu
    Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, Maine 04609
    J Neurosci 35:4587-98. 2015
    ..Microtubule-associated protein 1A (MAP1A) is one of the most abundantly expressed MAPs in the mammalian brain...
  32. pmc Six stroma-based RNA markers diagnostic for prostate cancer in European-Americans validated at the RNA and protein levels in patients in China
    Jianguo Zhu
    Guizhou Provincial Key Laboratory of Computational Nano material Science, Guizhou Normal College, Guiyang, China
    Oncotarget 6:16757-65. 2015
    ..study, we used prostate tissues from Chinese cases to validate six of these markers (CAV1, COL4A2, HSPB1, ITGB3, MAP1A and MCAM)...
  33. pmc Transforming Growth Factor TGFβ Increases Levels of Microtubule-Associated Protein MAP1S and Autophagy Flux in Pancreatic Ductal Adenocarcinomas
    Kun Song
    Department of General Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, 410008, Changsha, Hunan Province, China
    PLoS ONE 10:e0143150. 2015
    ..protein MAP1S (originally named C19ORF5) is a widely-distributed homologue of neuronal-specific MAP1A and MAP1B with which autophagy marker light chain 3 (LC3) was originally co-purified...
  34. doi Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A
    Yosuke Takei
    Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan, Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Neurosci 35:15539-54. 2015
    Microtubule-associated protein 1A (MAP1A) is a member of the major non-motor microtubule-binding proteins...
  35. pmc Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway
    Tao Wu
    Department of Medical Oncology, The First Affiliated Hospital of Xi an Jiaotong University, Xi an, Shaanxi, People s Republic of China
    Drug Des Devel Ther 9:6421-31. 2015
    ..When exposed to cisplatin, lung adeno-carcinoma cells demonstrated increased levels of autophagy detected by MAP1A/1B LC3B and mammalian homologue of yeast Atg6 (Beclin-1) expression using Western blot analysis...
  36. pmc Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals
    John D Eicher
    Population Sciences Branch, National Heart Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, USA
    Am J Hum Genet 99:40-55. 2016
    ..the literature across the allele frequency spectrum, including rare large effect (FCER1A), low-frequency (IQGAP2, MAP1A, LY75), and common (ZMIZ2, SMG6, PEAR1, ARFGAP3/PACSIN2) variants...
  37. doi Microtubule Associated Protein (MAP) 1B: Novel Paraneoplastic Biomarker Running head: MAP 1B-IgG: novel paraneoplastic biomarker
    Avi Gadoth
    Departments of Laboratory Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, USA, 55905
    Ann Neurol . 2017
    ..A minority (17.5%) of patients' IgG also bound to MAP1A. PCA-2 was often accompanied by additional neural autoantibody markers of small-cell carcinoma, including CRMP-5-..
  38. ncbi Differential distribution of MAP1A isoforms in the adult mouse barrel cortex and comparison with the serotonin 5-HT2A receptor
    F Touri
    Institut de Biologie Cellulaire et de Morphologie, Universite de Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
    J Chem Neuroanat 27:99-108. 2004
    Microtubule-associated protein 1A (MAP1A) is essential during the late differentiation phase of neuronal development...
  39. pmc The MAP1 family of microtubule-associated proteins
    Shelley Halpain
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Genome Biol 7:224. 2006
    ..The founding members, MAP1A and MAP1B, are predominantly expressed in neurons, where they are thought to be important in the formation and ..
  40. doi A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain
    Philip Long
    Neurodegenerative Disease Research Group, Institute of Pharmaceutical Sciences, School of Biomedical Sciences, King s College, London, UK
    Eur J Neurosci 36:2733-42. 2012
    ..These included: MAP1A and MAP1B, which regulate microtubule stability; RNF138, an E3 ubiquitin-ligase; proteasome β1 subunit, a subunit ..
  41. doi Novel disease-specific promoters for use in gene therapy for Parkinson's disease
    Erika Elgstrand Wettergren
    CNS Gene Therapy Unit, BMC A11, Dept of Experimental Medical Science, Lund University, S 221 84 Lund, Sweden
    Neurosci Lett 530:29-34. 2012
    ..previous studies; Drd1a, Drd2 and pDyn, or from a microarray study on parkinsonian patients; ACE, DNAJC3, GALNS, MAP1a and RNF25...
  42. ncbi Altered levels and distribution of microtubule-associated proteins before disease onset in a mouse model of amyotrophic lateral sclerosis
    C Abi Farah
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec, Canada
    J Neurochem 84:77-86. 2003
    ..Our results show that the protein levels of MAP2, MAP1A, tau 100 kDa and tau 68 kDa species decrease significantly as early as 5 months before onset of symptoms in the ..
  43. pmc An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice
    Dennis M Maddox
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Invest Ophthalmol Vis Sci 53:1663-9. 2012
    ..To identify genes that modify photoreceptor cell loss in the retinas of homozygous Tulp1(tm1Pjn) and Tub(tub) mice, which exhibit juvenile retinitis pigmentosa...
  44. pmc Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects
    Vanja Duric
    Department of Psychiatry, Yale University, New Haven, CT 06508, USA
    Int J Neuropsychopharmacol 16:69-82. 2013
    ..demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and GLUR3...
  45. pmc Structure of an enzyme-derived phosphoprotein recognition domain
    Christopher A Johnston
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon, United States of America
    PLoS ONE 7:e36014. 2012
    ..Mutational analysis reveals that the GBD is also used to bind the GK ligand MAP1a, suggesting that this is a common mode of MAGUK complex assembly...
  46. ncbi Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases
    M Wallin
    Department of Zoophysiology, University of Goteborg, Sweden
    J Gen Virol 71:1985-91. 1990
    ..It is suggested that proteolysis of microtubular proteins by viral proteinases is an important step in viral pathogenicity and that it may be part of a mechanism causing degenerative effects in infected cells...
  47. ncbi Molecular cloning of microtubule-associated protein 1 (MAP1A) and microtubule-associated protein 5 (MAP1B): identification of distinct genes and their differential expression in developing brain
    C C Garner
    Friedrich Miescher Institute, Basel, Switzerland
    J Neurochem 55:146-54. 1990
    cDNA clones encoding microtubule-associated proteins 1 (MAP1/MAP1A) and 5 (MAP5/MAP1B) were isolated and have been used to study their structural relationship as well as their regulated expression in developing rat brain...
  48. pmc Differential distribution of beta-tubulin isotypes in cerebellum
    R D Burgoyne
    Physiological Laboratory, University of Liverpool, UK
    EMBO J 7:2311-9. 1988
    ..beta 2 and M beta 6, the patterns of expression are similar or identical to the patterns of expression of MAP3 and MAP1A respectively...
  49. ncbi MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS
    T A Schoenfeld
    Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545
    J Neurosci 9:1712-30. 1989
    ..1984). These proteins were termed MAP 1A, 1B, 1C, 2A, and 2B...
  50. ncbi Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15
    L L Lien
    Department of Genetics, Harvard Medical School, Boston, Massachusetts
    Genomics 22:273-80. 1994
    ..with the sequence databases, we have identified a MAP1B-related gene that is probably the human homologue of rat MAP1A. This gene is expressed at high levels in brain and spinal cord and much lower levels in muscle and maps to the ..
  51. ncbi Microtubule-associated proteins, MAP 1A and MAP 1B, interact with F-actin in vitro
    T Fujii
    Department of Functional Polymer Science, Faculty of Textile Science and Technology, Shinshu University, Nagano
    J Biochem 114:827-9. 1993
    Microtubule-associated protein (MAP) 1 consisting of MAP 1A and 1B was purified from rat brain by the poly-L-aspartic acid (PLAA) method. We found that MAP 1 bound to F-actin in vitro up to a molar ratio of MAP 1 to actin monomers of 1:10...
  52. ncbi Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B
    S S Mann
    Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Winston Salem, North Carolina 27157 1010
    J Biol Chem 269:11492-7. 1994
    Light chain 3 (LC3) is a subunit of the neuronal microtubule-associated proteins (MAPs), MAP1A and MAP1B...
  53. ncbi Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression
    J K Fink
    Department of Neurology, University of Michigan, Ann Arbor 48109, USA
    Genomics 35:577-85. 1996
    ..b>MAP1a (HGMW-approved symbol MAP1A) stabilizes microtubules in postnatal axons...
  54. ncbi Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B
    S S Mann
    Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Winston Salem, North Carolina, USA
    J Neurosci Res 43:535-44. 1996
    Microtubule-associated proteins 1A (MAP1A) and MAP1B are abundant neuronal MAPs thought to be involved in neurite formation and stabilization...
  55. ncbi Characterization of the microtubule-binding domain of microtubule-associated protein 1A and its effects on microtubule dynamics
    A R Vaillant
    Department of Biology, University of Ottawa, Ottawa K1N 6N5, Canada
    J Biol Chem 273:13973-81. 1998
    To determine how MAP1a interacts with microtubules we expressed several 6myc-tagged MAP1a fragments in P19 EC and HeLa cells...
  56. ncbi The mouse and rat MAP1B genes: genomic organization and alternative transcription
    W Kutschera
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, Austria
    Genomics 49:430-6. 1998
    ..transcripts and the N-terminal amino acid sequence of the putative truncated MAP1B isoforms resemble those of MAP1A, providing further evidence for an evolutionary relationship...
  57. ncbi Microtubule-associated protein 1a is involved in the early development of the rat spinal cord
    M Oudega
    Department of Neurosurgery, Medical Faculty, University of Leiden, The Netherlands
    Neurosci Lett 246:81-4. 1998
    The expression of microtubule-associated protein 1a (MAP1a) in the developing rat spinal cord was studied using the monoclonal antibody BW6...
  58. ncbi Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment
    Y Sato
    Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Seiryomachi, Aobaku, Sendai, 980 8575, Japan
    J Biochem 124:209-16. 1998
    ..sequence of the cDNA was a newly identified membrane protein with direct repeats of the KKD/E units found in MAP1A and MAP1B, which is involved in the association with microtubules...
  59. ncbi Cytogenetic localization of cancer-related genes in the rat and comparative mapping studies in human and mouse
    A Johansson
    Department of Cell and Molecular Biology Genetics, Gothenburg University, Gothenburg, Sweden
    Cytogenet Cell Genet 81:217-21. 1998
    ..The remaining gene (Map1a) is involved in microtubule assembly.
  60. pmc A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome
    J Hirst
    University of Cambridge, Department of Clinical Biochemistry, Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease, Cambridge CB2 2XY, United Kingdom
    J Cell Biol 149:67-80. 2000
    ..These results indicate that the function of the GGAs is to facilitate the trafficking of proteins between the TGN and the vacuole, or its mammalian equivalent, the lysosome...
  61. ncbi Expression of MAP1a and MAP1b in the ganglionic eminence and the internal capsule of the human fetal brain
    N Ulfig
    Neuroembryonic Research Laboratory, Department of Anatomy, University of Rostock, Gertrudenstr 9, D 18055 Rostock, Germany
    Neurosci Res 38:397-405. 2000
    The expression of microtubule-associated proteins 1a and 1b (MAP1a and 1b) were investigated in two transient structures, the ganglionic eminence (GE) being a prominent part of the telencephalic proliferative zone and the perireticular ..
  62. ncbi Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation
    C Bonnet
    Biochimie Cellulaire, CNRS FRE 2219, Universite Pierre et Marie Curie, 9 quai Saint Bernard, Case 265, 75252 Paris, Cedex 05, France
    J Biol Chem 276:12839-48. 2001
    ..assays, we have tested the ability of polyglutamylation to modulate the interaction of two other structural MAPs, MAP1A and MAP1B, with tubulin...
  63. ncbi Characterization of two promoters that regulate alternative transcripts in the microtubule-associated protein (MAP) 1A gene
    A Nakayama
    Department of Pathology, Nagoya Univerty School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Aichi, Japan
    Biochim Biophys Acta 1518:260-6. 2001
    ..In addition, an NF-1 site, an HNF3B site, and an AP-1/ATF site were necessary for basal promoter activity of the intronic promoter. Our data provide insight into the regulatory mechanisms that govern the expression of the MAP1A gene.
  64. ncbi Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties
    Rainer Noiges
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, A 1030 Vienna, Austria
    J Neurosci 22:2106-14. 2002
    The microtubule-associated proteins 1A (MAP1A) and 1B (MAP1B) are distantly related protein complexes consisting of heavy and light chains and are thought to play a role in regulating the neuronal cytoskeleton, MAP1B during ..
  65. ncbi Similar ultrastructural distribution of the 5-HT(2A) serotonin receptor and microtubule-associated protein MAP1A in cortical dendrites of adult rat
    V Cornea-Hébert
    Départements de pathologie et biologie cellulaire et de physiologie, Faculte de Medecine, Universite de Montreal, P O Box 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Neuroscience 113:23-35. 2002
    ..results suggesting an association of 5-HT(2A) receptors with the cytoskeletal microtubule-associated protein MAP1A, the respective subcellular distributions of the receptors and of MAP1A were compared by quantitative electron ..
  66. ncbi Distribution and gene expression of cytoskeletal proteins in two-cell rat embryos and developmental arrest
    Hiromichi Matsumoto
    Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    J Exp Zool 293:641-8. 2002
    ..Although distributions of alpha-actinin, MAP1A, MAP1B/MAP5, and MAP2 were disturbed in arrested embryos, these abnormal distributions occurred following the ..
  67. ncbi Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter
    Atsuo Nakayama
    Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Aichi, Japan
    J Biol Chem 278:233-40. 2003
    Microtubule-associated protein MAP1A is expressed abundantly in mature neurons and is necessary for maintenance of neuronal morphology and localization of some molecules in association with the microtubule-based cytoskeleton...
  68. ncbi Functional analysis of the nucleotide binding domain of membrane-associated guanylate kinases
    Olav Olsen
    Department of Physiology and Program in Neuroscience, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Biol Chem 278:6873-8. 2003
    ..Protein ligands for the PSD-95 guanylate kinase domain, guanylate kinase-associated protein (GKAP) and MAP1A, appear not to interact with the canonical GMP binding pocket, and GMP binding does not influence the ..
  69. ncbi Selective changes in the neurofilament and microtubule cytoskeleton of NF-H/LacZ mice
    Irène M Riederer
    Institut de Biologie Cellulaire et de Morphologie, Lausanne, Switzerland
    J Neurosci Res 71:196-207. 2003
    ..b>MAP1A was the only MAP with a reduced signal in spinal cord tissue, and differences in immunostaining in various brain ..
  70. pmc Transcortical alterations in Na(+)-K+ ATPase and microtubule-associated proteins immunoreactivity in the rat cortical atrophy model induced by hypoxic ischemia
    Jun Gyo Suh
    Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University, Chunchon 200 702, South Korea
    Neural Plast 9:135-46. 2002
    ..In contrast, 2 to 7 days after ischemia, MAP1A and MAP2 immunoreactivity in the ipsi- and contralateral cortex significantly decreased, whereas in layer V, MAP1 ..
  71. ncbi DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
    Jill A Morris
    Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA
    Hum Mol Genet 12:1591-608. 2003
    ..co-immunoprecipitation assays with multiple proteins of the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin2 and beta4-spectrin; and ..
  72. ncbi Distribution of MAP1A, MAP1B, and MAP2A&B during layer formation in the optic tectum of developing chick embryos
    Yuko Yasuda
    Cell Biology Section, Division of Basic Research, Louis Pasteur Center for Medical Research, 103 5 Tanaka, Monzen cho, Sakyo ku, 606 8225 Kyoto, Japan
    Cell Tissue Res 314:315-24. 2003
    The expression patterns of three microtubule-associated proteins (MAP1A, MAP1B, and MAP2A&B) were investigated in the developing optic tectum...
  73. ncbi Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein
    Elaine Y M Wong
    Department of Obstetrics and Gynaecology, University of Hong Kong, China
    Biol Reprod 70:775-84. 2004
    ..3% and 41.9% homology to two human microtubule-associated proteins (MAPs), MAP1B and MAP1A, respectively...
  74. pmc Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A
    Maria M Magiera
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Davidson Building, Glasgow G12 8QQ, Scotland, UK
    Biochem J 382:803-10. 2004
    ..as bait in two-hybrid screens of foetal and adult human brain libraries, we identified the LC2 (light chain 2) of MAP1A (microtubule-associated protein 1A) as a protein capable of interaction with EPAC1...
  75. ncbi Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor
    Martin H Maurer
    Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    J Neurochem 91:1007-17. 2004
    ..Coupling to MAP1a has been described for another cognate GPCR, the 5-hydroxytryptamine (5HT) 2a receptor...
  76. ncbi Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family
    Zsuzsanna Orbán-Németh
    Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, Dr Bohr Gasse 9, A 1030 Vienna, Austria
    J Biol Chem 280:2257-65. 2005
    The related high molecular mass microtubule-associated proteins (MAPs) MAP1A and MAP1B are predominantly expressed in the nervous system and are involved in axon guidance and synaptic function...
  77. ncbi MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion
    Mona Gupta
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Davidson Building, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 280:8109-16. 2005
    We have recently demonstrated that light chain 2 (LC2) of the microtubule-associated protein MAP1A interacts with the cyclic AMP (cAMP)-binding domain of exchange protein directly activated by cyclic AMP 1 (EPAC1)...
  78. ncbi Tau pathology in Alzheimer disease and other tauopathies
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Biochim Biophys Acta 1739:198-210. 2005
    ..While the loss of functional tau can be compensated by the other two neuronal microtubule-associated proteins, MAP1A/MAP1B and MAP2, it is the dysfunctional, i.e...
  79. ncbi Interaction of casein kinase 1 delta (CK1 delta) with the light chain LC2 of microtubule associated protein 1A (MAP1A)
    Sonja Wolff
    Department of Visceral and Transplantation Surgery at the Medical University of Ulm, Chirurgische Universitätsklinik Ulm, Steinhovelstr 9, 89075 Ulm, Germany
    Biochim Biophys Acta 1745:196-206. 2005
    ..We have now identified a 176 aa fragment of the light chain LC2 of MAP1A (termed LC2-P16) specifically interacting with CK1delta...
  80. ncbi Activity-driven dendritic remodeling requires microtubule-associated protein 1A
    Györgyi Szebenyi
    Center for Basic Neuroscience, University of Texas, Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9111, USA
    Curr Biol 15:1820-6. 2005
    ..Less is known about MAP1A, but it is also enriched in dendrites at input locations, including PSDs where MAP1A associates with channel ..
  81. ncbi Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity
    David M Longhurst
    Centre for Neuroscience Research, The University of Edinburgh, Edinburgh EH9 1QH, Scotland, United Kingdom
    J Biol Chem 281:12030-40. 2006
    ..This coordinated action of the actin and microtubular cytoskeletons is essential for the development and maintenance of neuronal polarity...
  82. pmc p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling
    Douglas J Sheffler
    Departments of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 103:4717-22. 2006
    ..Because RSK2-inactivating mutations in humans lead to Coffin-Lowry syndrome, our results imply that alterations in GPCR signaling may account for some of its clinical manifestations...
  83. ncbi MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer
    M Leszczyniecka
    Novartis Pharmaceuticals, East Hanover, NJ, USA
    Oncogene 25:3471-8. 2006
    ..To date, only two MAP family members, MAP1A and MAP2, have been well characterized and studied in mammals...
  84. ncbi Spastic paraplegia with thin corpus callosum: description of 20 new families, refinement of the SPG11 locus, candidate gene analysis and evidence of genetic heterogeneity
    Giovanni Stevanin
    INSERM U679, Salpetriere Hospital, 47 Boulevard de l Hopital, 75013 Paris, France
    Neurogenetics 7:149-56. 2006
    ..allowed significant refinement to 6 cM, of the minimal chromosomal interval, but analysis of two genes (MAP1A and SEMA6D) in this region did not identify causative mutations...
  85. ncbi Heterotypic complex formation between subunits of microtubule-associated proteins 1A and 1B is due to interaction of conserved domains
    Rainer Noiges
    Max F Perutz Laboratories, Department of Molecular Cell Biology, University of Vienna, Dr Bohr Gasse 9, A 1030 Vienna, Austria, Europe
    Biochim Biophys Acta 1763:1011-6. 2006
    The microtubule-associated proteins MAP1A and MAP1B are related but distinct multi-subunit protein complexes that consist of heavy and light chains. The predominant forms of these complexes are homotypic, i.e...
  86. ncbi The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a
    Michael L Reese
    Graduate Group in Biophysics, University of California, San Francisco, California 94143, USA
    Nat Struct Mol Biol 14:155-63. 2007
    ..Here, we show that this canonical GMP-binding region interacts with microtubule-associated protein-1a (MAP1a) and we present a structural model...
  87. ncbi Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neurosci Lett 417:316-21. 2007
    ..As interacting-proteins with DISC1, Nudel, ATF4, ATF5, LIS1, alpha-tubulin, PDE4B, eIF3, FEZ1, Kendrin, MAP1A and MIPT3 were identified...
  88. ncbi MAP1A light chain-2 interacts with GTP-RhoB to control epidermal growth factor (EGF)-dependent EGF receptor signaling
    Isabelle Lajoie-Mazenc
    INSERM U563, Département Oncogénèse, Signalisation et Innovation thérapeutique, Toulouse F 31059, France
    J Biol Chem 283:4155-64. 2008
    ..glutathione S-transferase pulldown assay, we identified LC2, the light chain of the microtubule-associated protein MAP1A, as a novel binding partner for RhoB...
  89. doi MAP1 structural organization in Drosophila: in vivo analysis of FUTSCH reveals heavy- and light-chain subunits generated by proteolytic processing at a conserved cleavage site
    Beiyan Zou
    Department of Biology, Center for Molecular and Cellular Neuroscience, and Intercollege Graduate Program in Genetics, 201 Life Sciences Building, Pennsylvania State University, University Park, PA 16802, USA
    Biochem J 414:63-71. 2008
    ..MAP1 (microtubule-associated protein 1) family is a class of microtubule-binding proteins represented by mammalian MAP1A, MAP1B and the recently identified MAP1S...
  90. doi Isolation of microtubules and microtubule proteins
    J Avila
    Centro de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Curr Protoc Cell Biol . 2008
    ..chiefly alpha- and beta-tubulin, and the most significant microtubule associated proteins (MAPs), specifically MAP1A, MAP1B, MAP2, and tau...
  91. pmc Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly
    Khalid Iqbal
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    J Alzheimers Dis 14:365-70. 2008
    ..tau sequesters not only normal tau, but also the other two neuronal microtubule associated proteins (MAPs), MAP1A / MAP1B and MAP2, and causes inhibition and disruption of microtubules...
  92. doi Modulation of microtubule dynamics by the microtubule-associated protein 1a
    Elliott M Faller
    Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    J Neurosci Res 87:1080-9. 2009
    ..The purpose of this study was to measure the impact of myc-tagged MAP1a fragments on microtubule dynamic phases in vivo...
  93. pmc The role of MAP1A light chain 2 in synaptic surface retention of Cav2.2 channels in hippocampal neurons
    A G Miriam Leenders
    Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3701, USA
    J Neurosci 28:11333-46. 2008
    ..2 is mediated through its interaction with light chain 2 (LC2) of microtubule-associated protein MAP1A. Deletion of a 23-residue binding domain within the Ca(v)2...
  94. doi MAP1a associated light chain 3 increases microtubule stability by suppressing microtubule dynamics
    Elliott M Faller
    University of Ottawa, Department of Biology, Gendron Hall, 30 Marie Curie, Ottawa, Ontario, Canada
    Mol Cell Neurosci 41:85-93. 2009
    ..b>MAP1a is the most abundant MAP in the adult brain, localized in axons and dendrites of neurons...
  95. pmc Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses
    Liisa Tomppo
    Institute for Molecular Medicine Finland FIMM and National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 65:1055-62. 2009
    ..Because both DISC1 and NDE1 display association in our study sample, we hypothesized that other genes interacting with DISC1 might also have a role in the etiology of schizophrenia...
  96. doi Mathematical modeling and parameter estimation of axonal cargo transport
    Kouroush Sadegh Zadeh
    Fischell Department of Bioengineering, University of Maryland, 3236 Kim Engineering Building, College Park, MD 20742, USA
    J Comput Neurosci 28:495-507. 2010
    ..dataset based on measured motility parameters as well as experimental data of microtubule-associated protein MAP1A transport in mouse retinal ganglion cells (Nixon et al...
  97. pmc LC3-dependent intracellular membrane tubules induced by gamma-protocadherins A3 and B2: a role for intraluminal interactions
    Hugo H Hanson
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Biol Chem 285:20982-92. 2010
    ..These tubules recruit the autophagy marker MAP1A/1B LC3 (LC3) but are not associated with autophagic vesicles...
  98. pmc Gamma-diketone axonopathy: analyses of cytoskeletal motors and highways in CNS myelinated axons
    Lihai Zhang
    Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10467 2490, USA
    Toxicol Sci 117:180-9. 2010
    ..of microtubule-associated proteins (MAPs) in microtubule preparations revealed substantial reductions (45-80%) in MAP1A, MAP1B heavy chain, MAP2, and tau regardless of HD dose rate. MAP1B light chain content was not altered...
  99. pmc Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration
    Jeremy H Herskowitz
    Department of Neurology, The Center for Neurodegenerative Diseases, Laboratory Medicine, and Proteomics Service Center, Emory University School of Medicine, Atlanta, Georgia 30322, United States
    J Proteome Res 9:6368-79. 2010
    ..glial fibrillary acidic protein (GFAP) had an increased number of phosphospectra in FTLD, whereas microtubule associated protein 1A (MAP1A), reticulon 4 (RTN4; also referred to as neurite outgrowth inhibitor (Nogo)), protein kinase ..
  100. pmc Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation
    Rui Xie
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 286:10367-77. 2011
    ..distributed MAP1S is a homologue of the exclusively neuronal distributed microtubule-associated protein 1A and 1B (MAP1A/B). They give rise to multiple isoforms through similar post-translational modification...
  101. pmc A population genetic approach to mapping neurological disorder genes using deep resequencing
    Rachel A Myers
    Department of Pediatrics, University of Montreal, Montreal, Canada
    PLoS Genet 7:e1001318. 2011
    ..Three genes, MAP1A, GRIN2B, and CACNA1F, were consistently identified by different methods as having significant excess of rare ..

Research Grants2

  1. MAP1A AND MAP1B--SYNTHESIS, STRUCTURE/FUNCTION
    JAMES HAMMARBACK; Fiscal Year: 2000
    ..The last two aims directly test the role of MAP1 proteins in establishing, organizing and maintaining the axonal cytoskeleton. ..
  2. Tau phosphorylation and neurodegeneration
    Alejandra del C Alonso; Fiscal Year: 2009
    ..their ability to self-assembly, promote and inhibit the promotion of microtubule and its binding to normal tau, MAP1A, MAP1B and MAP2 will be studied...