MIR122

Summary

Gene Symbol: MIR122
Description: microRNA 122
Alias: MIR122A, MIRN122, MIRN122A, hsa-mir-122, miRNA122, miRNA122A
Species: human

Top Publications

  1. pmc Downregulation of miR-122 in the rodent and human hepatocellular carcinomas
    Huban Kutay
    Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 99:671-8. 2006
  2. pmc Silencing of microRNA-122 enhances interferon-α signaling in the liver through regulating SOCS3 promoter methylation
    Takeshi Yoshikawa
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Sci Rep 2:637. 2012
  3. pmc microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma
    Julja Burchard
    Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck and Co, Inc, Seattle, WA, USA
    Mol Syst Biol 6:402. 2010
  4. pmc Human Ago2 is required for efficient microRNA 122 regulation of hepatitis C virus RNA accumulation and translation
    Joyce A Wilson
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada
    J Virol 85:2342-50. 2011
  5. doi Clinical significance and potential of hepatic microRNA-122 expression in hepatitis C
    Kazutoyo Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Liver Int 31:474-84. 2011
  6. pmc Two-tiered approach identifies a network of cancer and liver disease-related genes regulated by miR-122
    Daniel R Boutz
    Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
    J Biol Chem 286:18066-78. 2011
  7. pmc CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation
    David M Burns
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 473:105-8. 2011
  8. pmc Modulation of the unfolded protein response is the core of microRNA-122-involved sensitivity to chemotherapy in hepatocellular carcinoma
    Fu Yang
    Department of Medical Genetics, The Second Military Medical University, Shanghai, China
    Neoplasia 13:590-600. 2011
  9. pmc A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication
    Yanni Chen
    State Key Laboratory of Virology and College of Life Sciences, Wuhan Institutes of Biotechnology, Chinese French Liver Disease Research Institute at Zhongnan Hospital, Wuhan University, Wuhan, China
    FASEB J 25:4511-21. 2011
  10. doi Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity
    Saifeng Wang
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing, PR China
    Hepatology 55:730-41. 2012

Scientific Experts

Detail Information

Publications90

  1. pmc Downregulation of miR-122 in the rodent and human hepatocellular carcinomas
    Huban Kutay
    Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 99:671-8. 2006
    ..013) reduced in 10 out of 20 tumors compared to the pair-matched control tissues. These findings suggest that the downregulation of miR-122 is associated with hepatocarcinogenesis and could be a potential biomarker for liver cancers...
  2. pmc Silencing of microRNA-122 enhances interferon-α signaling in the liver through regulating SOCS3 promoter methylation
    Takeshi Yoshikawa
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Sci Rep 2:637. 2012
    ..Overexpression of microRNA-122 (miR122) significantly suppressed ISRE activity...
  3. pmc microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma
    Julja Burchard
    Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck and Co, Inc, Seattle, WA, USA
    Mol Syst Biol 6:402. 2010
    ..In conclusion, miR-122 regulates mitochondrial metabolism and its loss may be detrimental to sustaining critical liver function and contribute to morbidity and mortality of liver cancer patients...
  4. pmc Human Ago2 is required for efficient microRNA 122 regulation of hepatitis C virus RNA accumulation and translation
    Joyce A Wilson
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada
    J Virol 85:2342-50. 2011
    ..These data support a model in which miR-122 functions within an Ago2-containing protein complex to augment both HCV RNA accumulation and translation...
  5. doi Clinical significance and potential of hepatic microRNA-122 expression in hepatitis C
    Kazutoyo Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Liver Int 31:474-84. 2011
    ..Liver-specific microRNA-122 (miR-122) has been shown to facilitate the replication of hepatitis C virus (HCV) in human hepatoma cells in vitro. However, the clinical significance of hepatic miR-122 on HCV in human body is unclear...
  6. pmc Two-tiered approach identifies a network of cancer and liver disease-related genes regulated by miR-122
    Daniel R Boutz
    Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
    J Biol Chem 286:18066-78. 2011
    ..Additional analyses, including examination of consensus binding motifs for both miR-122 and target sequences, provide further insight into miR-122 function...
  7. pmc CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation
    David M Burns
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 473:105-8. 2011
    ..Thus, translational regulation of p53 mRNA and cellular senescence is coordinated by Gld2/miR-122/CPEB/Gld4...
  8. pmc Modulation of the unfolded protein response is the core of microRNA-122-involved sensitivity to chemotherapy in hepatocellular carcinoma
    Fu Yang
    Department of Medical Genetics, The Second Military Medical University, Shanghai, China
    Neoplasia 13:590-600. 2011
    ..We identified a new HCC therapeutic target and proclaimed the potential risk of the therapeutic use of miR-122 silencing...
  9. pmc A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication
    Yanni Chen
    State Key Laboratory of Virology and College of Life Sciences, Wuhan Institutes of Biotechnology, Chinese French Liver Disease Research Institute at Zhongnan Hospital, Wuhan University, Wuhan, China
    FASEB J 25:4511-21. 2011
    ....
  10. doi Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity
    Saifeng Wang
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing, PR China
    Hepatology 55:730-41. 2012
    ..Finally, we show that miR-122 suppressed HBV replication in p53 wildtype cells but not in null isogenic cells...
  11. pmc Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation
    Christine J Jung
    Transplant Research Program, University of California Davis Medical Center, Sacramento, California, United States of America
    PLoS ONE 6:e27740. 2011
    ....
  12. pmc Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex
    Tetsuro Shimakami
    Lineberger Comprehensive Cancer Center and Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7292, USA
    Proc Natl Acad Sci U S A 109:941-6. 2012
    ..miR-122 thus acts in an unconventional fashion to stabilize HCV RNA and slow its decay, expanding the repertoire of mechanisms by which miRNAs modulate gene expression...
  13. pmc MiR-122 in hepatic function and liver diseases
    Jun Hu
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing 100101, China
    Protein Cell 3:364-71. 2012
    ....
  14. ncbi Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
    Laura Gramantieri
    Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
    Cancer Res 67:6092-9. 2007
    ..These results indicate that cyclin G1 is a target of miR-122a and expand our knowledge of the molecular alterations involved in HCC pathogenesis and of the role of miRNAs in human cancer...
  15. doi Requirements for human Dicer and TRBP in microRNA-122 regulation of HCV translation and RNA abundance
    Chao Zhang
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5
    Virology 433:479-88. 2012
    ..Thus, canonical miRNA processing and strand selection is essential for the activity of miR-122 on HCV translation and RNA accumulation...
  16. pmc Serum microRNA-122 predicts survival in patients with liver cirrhosis
    Oliver Waidmann
    Department of Medicine 1, Klinikum der Goethe Universität, Frankfurt, Germany
    PLoS ONE 7:e45652. 2012
    ..MicroRNAs (miRs) circulating in the blood are an emerging new class of biomarkers. In particular, the serum level of the liver-specific miR-122 might be a clinically useful new parameter in patients with acute or chronic liver disease...
  17. pmc miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression
    Jiang Li
    Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, United States
    J Hepatol 58:522-8. 2013
    ..miR-122 has been extensively studied in hepatocarcinogenesis. However, the role of miR-122 in liver fibrosis remains unknown...
  18. pmc Specific miRNA stabilization by Gld2-catalyzed monoadenylation
    Andrea D'Ambrogio
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Rep 2:1537-45. 2012
    ..These results establish a mechanism of miRNA stability and resulting posttranscriptional gene regulation...
  19. pmc Hepatitis B virus mRNA-mediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion
    Changfei Li
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing, China
    J Virol 87:2193-205. 2013
    ..Our work underscores the reciprocal interplay of host miRNA sequestration and depletion by viral mRNAs, which may contribute to chronic-infection-related cancer...
  20. pmc Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication
    You Li
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7292, USA
    Proc Natl Acad Sci U S A 110:1881-6. 2013
    ..Nevertheless, Xrn1 knockdown does not rescue replication of a viral mutant defective in miR-122 binding, indicating that miR-122 has additional yet uncharacterized function(s) in the viral life cycle...
  21. doi Overexpression of microRNA-122 enhances in vitro hepatic differentiation of fetal liver-derived stem/progenitor cells
    Ravi Doddapaneni
    Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
    J Cell Biochem 114:1575-83. 2013
    ..Thus, the study delineated the role of hepato-specific miR-122 in differentiation of fetal liver stem/progenitor cells into hepatocyte-like cells which could be used as a therapeutic target molecule to generate abundant hepatocytes...
  22. doi MiR-122 modulates type I interferon expression through blocking suppressor of cytokine signaling 1
    Aimei Li
    Department of Microbiology, Harbin Medical University, Harbin 150081, China
    Int J Biochem Cell Biol 45:858-65. 2013
    ..Mutations in the nt359-nt375 region abandoned the impact of miR-122 on SOCS1-EGFP expression. Taken together, SOCS1 is a target of miR-122. MiR-122 can regulate the type I IFN expression through modulating the SOCS1 expression...
  23. pmc Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells
    Kyoungsub Song
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA
    Hepatology 58:1681-92. 2013
    ..The aforementioned DNA-protein complex also contains SUV39H1, an H3K9 histone methyl transferase, which down-regulates miR-122 expression...
  24. doi Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma
    Verena Köberle
    Department of Medicine I, Division of Gastroenterology and Hepatology, Johann Wolfgang Goethe University Hospital Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Cancer 49:3442-9. 2013
    ..Extracellular microRNAs (miRNAs) circulating in the blood are a new class of highly promising disease markers...
  25. pmc miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma
    Angela M Liu
    Department of Pharmacology, National University of Singapore, Singapore Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    PLoS ONE 9:e86872. 2014
    ..The present study demonstrated the regulatory role of miR-122 on PKM2 in HCC, having an implication of therapeutic intervention targeting cancer metabolic pathways. ..
  26. doi MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma
    Wei Chih Tsai
    Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Hepatology 49:1571-82. 2009
    ....
  27. pmc MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism
    Dimitrios Iliopoulos
    Department of Biological Chemistry and Molecular Pharmacology, School of Medicine, Harvard University, Boston, MA, USA
    J Lipid Res 51:1513-23. 2010
    ....
  28. ncbi Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells
    Leina Ma
    Xinyuan Institute of Medicine and Biotechnology, School of Life Sciences, Zhejiang Sci Tech University, Hangzhou, Zhejiang, China
    Cancer Biol Ther 9:554-61. 2010
    ..In this study, we presented a novel strategy for cancer therapy based on gene transfer of miR-122 by adenoviral vector...
  29. pmc Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells
    Jinhong Chang
    Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, 3805 Old Easton Road, Doylestown, PA 18902, USA
    J Virol 82:8215-23. 2008
    ..Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells...
  30. pmc Modulation of hepatitis C virus RNA abundance and the isoprenoid biosynthesis pathway by microRNA miR-122 involves distinct mechanisms
    Kara L Norman
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305 5124, USA
    J Virol 84:666-70. 2010
    ..Loss of HCV RNA could not be restored by isoprenoid intermediate metabolites. Overall, these findings suggest that miR-122 modulates viral RNA abundance independently of its effect on isoprenoid metabolism...
  31. pmc Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
    C Coulouarn
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda 20892 4262, MD, USA
    Oncogene 28:3526-36. 2009
    ..From a clinical point of view, our study emphasizes miR-122 as a diagnostic and prognostic marker for HCC progression...
  32. pmc microRNA-122 stimulates translation of hepatitis C virus RNA
    Jura Inga Henke
    Institute of Biochemistry, Faculty of Medicine, Justus Liebig University, Giessen, Germany
    EMBO J 27:3300-10. 2008
    ..miR-122 stimulates HCV translation by enhancing the association of ribosomes with the viral RNA at an early initiation stage. In conclusion, the liver-specific miR-122 may contribute to HCV liver tropism at the level of translation...
  33. pmc Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122
    Rohit K Jangra
    Center for Hepatitis Research, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555 0610, USA
    J Virol 84:6615-25. 2010
    ..miR-122 is thus likely to act at an additional step in the virus life cycle...
  34. doi MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells
    Francesca Fornari
    Dipartimento di Medicina Clinica e CRBA, Policlinico S Orsola Malpighi, Bologna, Italy
    Cancer Res 69:5761-7. 2009
    ..Our findings establish a basis toward the development of combined chemo- and miRNA-based therapy for HCC treatment...
  35. doi Regulation of hepatitis C virus by microRNA-122
    Catherine L Jopling
    Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, UK
    Biochem Soc Trans 36:1220-3. 2008
    ..The binding site requirements for miR-122 to positively regulate HCV replication provide an insight into this unusual mode of miRNA action...
  36. doi Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells
    Jun Qian
    Department of Microbiology, Harbin Medical University Immunity and Infection, Pathogenic Biology Key Laboratory, Heilongjiang Province, Harbin 150086, China
    Antiviral Res 87:249-56. 2010
    ....
  37. doi Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans
    Rebecca T Marquez
    Department of Internal Medicine, University of Iowa School of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Lab Invest 90:1727-36. 2010
    ..We found that miR-21 enhanced TGF-β signaling, further supporting a relationship between miR-21 and fibrosis. We suggest a model in which miR-21 targeting of SMAD7 could increase TGF-β signaling, leading to increased fibrogenesis...
  38. doi miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines
    Cliff Ji Fan Lin
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Biochem Biophys Res Commun 375:315-20. 2008
    ..Thus, Bcl-w is a direct target of miR-122 that functions as an endogenous apoptosis regulator in these HCC-derived cell lines...
  39. pmc Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 133:1166-74. 2007
    ..This study was to assess whether a specific miR-122 antagomir down-regulates HCV protein replication and up-regulates HO-1...
  40. doi Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy
    Magdalena Sarasin-Filipowicz
    Department of Biomedicine, University of Basel, Basel, Switzerland
    Nat Med 15:31-3. 2009
    ..These data have implications for the prospect of targeting miRNAs for CHC therapy...
  41. pmc The effects of hepatitis C virus core protein on the expression of miR-122 in vitro
    Sujuan Li
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Institute of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Virol J 10:98. 2013
    ..However, the effects of HCV infection on miR-122 expression are not clear. The aim of this study was to investigate the effects of HCV core protein on the expression of miR-122 in a cell culture model...
  42. pmc MiR-122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R
    Biyun Wang
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, China
    PLoS ONE 7:e47053. 2012
    ..Given these, miR-122 may serve as a novel therapeutic or diagnostic/prognostic-target for treating BC...
  43. doi Methylation regulation of liver-specific microRNA-122 expression and its effects on the proliferation and apoptosis of hepatocellular carcinoma cells
    T J Xing
    Department of Infectious Diseases, Taizhou People s Hospital, Taizhou, China
    Genet Mol Res 12:3588-97. 2013
    ..Methylation regulation of miRNA-122 expression might be involved in the development of hepatocellular carcinoma. ..
  44. doi MiR-124 inhibits the growth of glioblastoma through the downregulation of SOS1
    Zhonghua Lv
    Department of Neurosurgery, the Third Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150066, P R China
    Mol Med Rep 8:345-9. 2013
    ..This study therefore indicates an important role for miR-124 in the regulation of growth in the molecular etiology of GBM, and offers a potential strategy for the use of miR-124 in cancer treatment...
  45. pmc Seminal miRNA Relationship with Apoptotic Markers and Oxidative Stress in Infertile Men with Varicocele
    Taymour Mostafa
    Department of Andrology and Sexology, Faculty of Medicine, Cairo University, Cairo, Egypt
    Biomed Res Int 2016:4302754. 2016
    ..In addition, they are positively correlated with sperm parameters and negatively correlated with OS, apoptotic markers...
  46. doi Single-Vehicular Delivery of Antagomir and Small Molecules to Inhibit miR-122 Function in Hepatocellular Carcinoma Cells by using "Smart" Mesoporous Silica Nanoparticles
    Changmin Yu
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 Singapore http staff science nus edu sg syao
    Angew Chem Int Ed Engl 54:10574-8. 2015
    ..The controlled release of both types of inhibitors depends on the expression levels of endogenous miR-122, thus enabling these drug-loaded MSNs to achieve combination inhibition of its targeted mRNAs in Huh7 cells. ..
  47. doi High circulating microRNA-122 expression is a poor prognostic marker in patients with hepatitis B virus-related hepatocellular carcinoma who undergo radiofrequency ablation
    Hyo Jung Cho
    Department of Gastroenterology, Ajou University School of Medicine, Suwon, South Korea
    Clin Biochem 48:1073-8. 2015
    ..Aim of this study was to investigate the prognostic potential of plasma microRNA-122 levels in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma after hepatic resection or radiofrequency ablation (RFA)...
  48. pmc Hepatitis C virus RNA functionally sequesters miR-122
    Joseph M Luna
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10065, USA Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Cell 160:1099-110. 2015
    ....
  49. pmc Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis
    Carmen Chak Lui Wong
    Department of Pathology, The University of Hong Kong, Hong Kong, HKSAR State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, HKSAR
    PLoS ONE 9:e115036. 2014
    ..Our clinical data and functional studies have revealed a novel biological mechanism involved in HCC metabolic reprogramming. ..
  50. pmc microRNA/Argonaute 2 regulates nonsense-mediated messenger RNA decay
    Junho Choe
    School of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
    EMBO Rep 11:380-6. 2010
    ..The regulation of NMD by miRNAs will shed light on a new post-transcriptional regulation mechanism of gene expression in mammalian cells...
  51. doi The association of the expression of miR-122-5p and its target ADAM10 with human breast cancer
    Sercan Ergun
    Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Sehitkamil, 27310, Gaziantep, Turkey
    Mol Biol Rep 42:497-505. 2015
    ....
  52. doi MicroRNA sponge blocks the tumor-suppressing functions of microRNA-122 in human hepatoma and osteosarcoma cells
    Ji Ma
    Central Laboratory, Shanghai Tenth People s Hospital of Tongji University, Shanghai 200072, P R China
    Oncol Rep 32:2744-52. 2014
    ..miR-122-SP therefore is a useful tool that may be utilized to study the functions of miR-122 with regard to liver development and tumorigenesis in vitro and in vivo...
  53. pmc MiR-122 directly inhibits human papillomavirus E6 gene and enhances interferon signaling through blocking suppressor of cytokine signaling 1 in SiHa cells
    Junming He
    Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China IBP UC Group for Immunotherapy, CAS Key Laboratory for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 9:e108410. 2014
    ..Thus, miR-122 may serve as a new therapeutic option for inhibiting HPV infection. ..
  54. doi A home-brew real-time PCR assay for reliable detection and quantification of mature miR-122
    Mahmood Naderi
    Departments of Medical Biotechnology Hematology, Faculty of Medical Sciences, Tarbiat Modares University Nanotechnology and Tissue Engineering Department, Stem Cell Technology Research Center Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Appl Immunohistochem Mol Morphol 23:601-6. 2015
    ..Therefore, this study can be considered as a start point for standardizing miR-122 quantification. ..
  55. doi MiR-122/Wnt/β-catenin regulatory circuitry sustains glioma progression
    Guangzhi Wang
    Department of Neurosurgery, Harbin Medical University Second Affiliated Hospital, 246 Xuefu Road, 150086, Harbin, China
    Tumour Biol 35:8565-72. 2014
    ..Taken together, we revealed that there is a miR-122/Wnt/β-catenin regulatory circuitry existing in glioma cells that contributes to glioma progression...
  56. doi miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn's disease
    Yu Chen
    Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434, China
    Biochem Biophys Res Commun 438:133-9. 2013
    ..Taken together, these results indicate that miR-122 and its target gene NOD2 may play an important role in the injury of intestinal epithelial cells induced by LPS. ..
  57. doi A novel strategy to inhibit the reproduction and translation of hepatitis C virus
    Aiping Duan
    Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China
    Sci China Life Sci 56:293-7. 2013
    ..This study presents a new method to inhibit HCV that may hold great potential for HCV treatment in the future...
  58. pmc MicroRNA-122 influences the development of sperm abnormalities from human induced pluripotent stem cells by regulating TNP2 expression
    Te Liu
    International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University, Shanghai, China
    Stem Cells Dev 22:1839-50. 2013
    ..MiR-122 may influence spermatozoa-like cells by suppressing TNP2 expression and inhibiting the expression of proteins associated with sperm development...
  59. pmc Alcohol facilitates HCV RNA replication via up-regulation of miR-122 expression and inhibition of cyclin G1 in human hepatoma cells
    Wei Hou
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    Alcohol Clin Exp Res 37:599-608. 2013
    ..The liver-specific microRNA-122 (miR-122) regulates HCV replication and expression of host genes, including Cyclin G1. Here, we hypothesized that alcohol regulates miR-122 expression and thereby modulates HCV RNA replication...
  60. pmc A miRNA-responsive cell-free translation system facilitates isolation of hepatitis C virus miRNP complexes
    Shelton S Bradrick
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    RNA 19:1159-69. 2013
    ..This combined approach may be generalizable to affinity purification of miRNP complexes for selected target mRNAs, allowing identification of miRNP components and RBPs that may contribute to regulation. ..
  61. pmc Inhibition of alpha interferon (IFN-α)-induced microRNA-122 negatively affects the anti-hepatitis B virus efficiency of IFN-α
    Junli Hao
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    J Virol 87:137-47. 2013
    ..These data provide valuable insights for a better understanding of the antiviral mechanism of IFN-α and raise further potential interest in enhancing its anti-HBV efficacy...
  62. ncbi [miR-122 participates in the cell tropism of hepatitis C virus]
    Takasuke Fukuhara
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University
    Uirusu 62:1-8. 2012
    ....
  63. pmc Structural map of a microRNA-122: hepatitis C virus complex
    Phillip S Pang
    Department of Medicinea and Protein and Nucleic Acid Facility, Stanford University School of Medicine, Stanford, California, USA
    J Virol 86:1250-4. 2012
    ..These additional interactions enhance HCV replication in cell culture. To our knowledge, this is the first biophysical study of this complex to reveal the importance of 'tail' miR-122 nucleotide interactions...
  64. pmc miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma
    Valentina Manfé
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
    PLoS ONE 7:e29541. 2012
    ..miR-122 is thus an amplifier of the antiapoptotic Akt/p53 circuit and it is conceivable that a pharmacological intervention in this pathway may provide basis for novel therapies for CTCL...
  65. doi MicroRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/β-catenin pathway
    Jie Xu
    Department of Oncological Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Liver Int 32:752-60. 2012
    ..To validate whether the anti-cancer effect of microRNA-122 (miR-122) on hepatocellular carcinoma (HCC) is mediated through regulating Wnt/β-catenin signalling pathways...
  66. pmc Plasma levels of lipometabolism-related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease
    Wei Gao
    Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    Lipids Health Dis 11:55. 2012
    ....
  67. doi Four serum microRNAs identified as diagnostic biomarkers of sepsis
    Hui Juan Wang
    Department of Respiratory Medicine, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan Province, China
    J Trauma Acute Care Surg 73:850-4. 2012
    ..Serum microRNAs (miRNAs) can be used as biomarkers for many kinds of diseases, and some are even better than current indicators. The aim of this study was to investigate a diagnostic role for serum miRNAs in sepsis patients...
  68. doi Circulating microRNAs identified in a genome-wide serum microRNA expression analysis as noninvasive biomarkers for endometriosis
    Wen Tao Wang
    Department of Obstetrics and Gynecology, Sun Yat Sen Memorial Hospital, Guangzhou 510120, People s Republic of China
    J Clin Endocrinol Metab 98:281-9. 2013
    ..There is currently no reliable noninvasive biomarker for the clinical diagnosis of endometriosis. Previous analyses have reported that circulating microRNAs (miRNAs) can serve as biomarkers for a number of diseases...
  69. pmc MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor
    Ryota Shizu
    Department of Biochemical Toxicology, Showa University School of Pharmacy, Tokyo, Japan
    PLoS ONE 7:e41291. 2012
    ..Taken together, these results suggest that phenobarbital-mediated down-regulation of miR-122 is an early and important event in the AMPK-dependent CAR activation and transactivation of its target genes...
  70. doi Effect of miR-122 and its target gene cationic amino acid transporter 1 on colorectal liver metastasis
    Ichirota Iino
    Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Cancer Sci 104:624-30. 2013
    ..Expression of CAT1 in the primary CRC has the potential to be a novel biomarker to predict the risk of postoperative liver metastasis of CRC patients...
  71. pmc Expression of microRNA miR-122 facilitates an efficient replication in nonhepatic cells upon infection with hepatitis C virus
    Takasuke Fukuhara
    Department of Molecular Virology, Osaka University, Osaka, Japan
    J Virol 86:7918-33. 2012
    ..In conclusion, although miR-122 facilitates efficient viral replication in nonhepatic cells, factors other than miR-122, which are most likely specific to hepatocytes, are required for HCV assembly...
  72. pmc Base pairing between hepatitis C virus RNA and microRNA 122 3' of its seed sequence is essential for genome stabilization and production of infectious virus
    Tetsuro Shimakami
    Division of Infectious Diseases, Department of Medicine, Inflammatory Diseases Institute and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Virol 86:7372-83. 2012
    ..These data add to the current understanding of miR-122 interactions with HCV RNA but indicate that base pairing between miR-122 and the 5' 43 nt of the HCV genome is more complex than suggested by existing models...
  73. doi miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3
    Chun Guang Fan
    Department of Pathophysiology, Shandong University School of Medicine, Jinan, PR China
    Oncol Rep 26:1281-6. 2011
    ..The data demonstrate that miR-122 plays an important role in HBV-related hepatocarcinogenesis by targeting NDRG3. Thus, miR-122 and NDRG3 represent key diagnostic markers and potential therapeutic targets for HBV-related HCC...
  74. pmc Differential stimulation of hepatitis C virus RNA translation by microRNA-122 in different cell cycle phases
    Carmen Fehr
    Institute of Biochemistry, Faculty of Medicine, Justus Liebig University, Giessen, Germany
    Cell Cycle 11:277-85. 2012
    ....
  75. pmc Establishment of a novel permissive cell line for the propagation of hepatitis C virus by expression of microRNA miR122
    Hiroto Kambara
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Virol 86:1382-93. 2012
    ..A liver-specific microRNA, miR122, has been shown to participate in the efficient replication of HCV...
  76. doi Competing roles of microRNA-122 recognition elements in hepatitis C virus RNA
    Neda Nasheri
    Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Canada K1A 0R6
    Virology 410:336-44. 2011
    ..These data have important implications in elucidating the mechanism of interaction between microRNA-122 and HCV RNA...
  77. doi MicroRNA expression in ACTH-producing pituitary tumors: up-regulation of microRNA-122 and -493 in pituitary carcinomas
    Gail Stilling
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Endocrine 38:67-75. 2010
    ..ac.uk ) both of which have been shown to have roles in pituitary tumor cell growth. These results provide information about marker miRNAs that may lead to further insights into the regulation of pituitary tumor growth and development...
  78. pmc A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes
    Kwang Hoon Song
    Department of Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA
    J Lipid Res 51:2223-33. 2010
    ..Under certain conditions, miRNA may reduce CYP7A1 mRNA stability to inhibit bile acid synthesis, and the miR-122a antagomirs may stimulate bile acid synthesis to reduce serum cholesterol and triglycerides...
  79. doi Proteomic identification of microRNA-122a target proteins in hepatocellular carcinoma
    Shu Diao
    Department of Chemistry, The Chinese University of Hong Kong, Hong Kong
    Proteomics 10:3723-31. 2010
    ..Luciferase reporter assay confirmed the regulation of miR-122a on 5'-UTR of PRDXII. In conclusion, PRDXII was identified to be the new target of miR-122a...
  80. pmc MicroRNA regulation of intestinal epithelial tight junction permeability
    Dongmei Ye
    Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
    Gastroenterology 141:1323-33. 2011
    ..We investigated the mechanisms by which TNF-α induces occludin depletion and an increase in intestinal TJ permeability...
  81. pmc Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies
    Svitlana Yu Berezhna
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    RNA 17:1831-45. 2011
    ..We propose a model in which partitioning of host RNAi and viral factors into physically and functionally distinct subcellular compartments emerges as a mechanism regulating the dual interaction of cellular RNAi with HCV RNA...
  82. doi miR-122 affects the viability and apoptosis of hepatocellular carcinoma cells
    Xia Wu
    Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China
    Scand J Gastroenterol 44:1332-9. 2009
    ..The absence of miR-122 expression in HepG2 cells was due to the loss of the miR-122 coding sequence in chromosome 18. These results imply that aberrant expression of miR-122 may contribute to hepatocarcinogenesis...
  83. doi MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers
    Xian Wang
    Department of Biology and Chemistry, City University of Hong Kong, Hong Kong, China
    Biochem Biophys Res Commun 387:376-80. 2009
    ..The down-regulation of miR-122a mediated by aberrant APC/beta-catenin signaling is important to the pathogenesis of gastrointestinal cancers...
  84. pmc miR-122 does not modulate the elongation phase of hepatitis C virus RNA synthesis in isolated replicase complexes
    Rodrigo A Villanueva
    Laboratorio de Virus Hepatitis, Programa de Virologia, Instituto de Ciencias Biomedicas ICBM, Facultad de Medicina, Universidad de Chile Avda Independencia 1027, Independencia 8380453, Santiago, Chile
    Antiviral Res 88:119-23. 2010
    ..These results are consistent with miR-122 acting at an alternative step in the viral life cycle, promoting cap-independent viral translation, enhancing viral RNA stability, or facilitating de novo initiation of viral RNA synthesis...
  85. ncbi [Detection of miR-122a and miR-224 expression in hepatocellular carcinoma by real-time fluorescence quantitative RT-PCR]
    Zhuo ran Liu
    Department of Clinical Laboratory, Second Affiliated Hospital, University of South China, Hengyang 421001, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:751-3. 2009
    ..To detect the expressions of miR-122 and miR-224 in hepatocellular carcinoma (HCC) by real-time fluorescence quantitative RT-PCR and investigate the significance of miRNAs in early diagnosis of HCC...
  86. doi An insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3' untranslated region confers risk for hepatocellular carcinoma
    Yuzhen Gao
    Laboratory of Cellular and Molecular Tumor Immunology, Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, Medical College, Soochow University, Suzhou 215123, Jiangsu, People s Repubic of China
    Carcinogenesis 30:2064-9. 2009
    ....
  87. doi Circulating microRNAs in hepatitis B virus-infected patients
    F Ji
    CAS Key Laboratory of Pathogenic Microbiology and Immunology, Center for Molecular Virology and Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Science, Beijing, China
    J Viral Hepat 18:e242-51. 2011
    ..In all, our study revealed that a number of miRNAs were differentially expressed during HBV infection and underscored the potential importance of miR-122 in the infection process...
  88. pmc MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR
    Yi Ping Li
    Copenhagen Hepatitis C Program CO HEP, Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, and Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, DK 2650 Hvidovre, Denmark
    Proc Natl Acad Sci U S A 108:4991-6. 2011
    ..5 cells. These mutations reduced the efficacy of SPC3649 treatment, indicating that escape variants to miR-122 antagonism-based HCV therapy could potentially occur...
  89. doi Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis
    Jian Xu
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
    Mol Carcinog 50:136-42. 2011
    ..Our results indicate that serum miR-21, miR-122 and miR-223 are elevated in patients with HCC or chronic hepatitis and these miRNAs have strong potential to serve as novel biomarkers for liver injury but not specifically for HCC...