MIR146A

Summary

Gene Symbol: MIR146A
Description: microRNA 146a
Alias: MIRN146, MIRN146A, miR-146a, miRNA146A
Species: human

Top Publications

  1. pmc NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    Konstantin D Taganov
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:12481-6. 2006
  2. doi MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins
    Yuanjia Tang
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, China
    Arthritis Rheum 60:1065-75. 2009
  3. doi Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case-control studies
    Jun Wang
    Department of Oncology, General Hospital, Jinan Command of the People s Liberation Army, Shifan Street 25, Tianqiao District, Jinan, 250031, China
    Mol Biol Rep 39:4571-9. 2012
  4. doi An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes
    Graziella Curtale
    Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Universita di Roma, Rome, Italy
    Blood 115:265-73. 2010
  5. pmc CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells
    Slava Rom
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    FASEB J 24:2292-300. 2010
  6. pmc Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling
    Md A Nahid
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    J Immunol 186:1723-34. 2011
  7. doi A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis
    Jie Shen
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 29:1963-6. 2008
  8. pmc Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease
    Jian Guo Cui
    Department of Ophthalmology, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 285:38951-60. 2010
  9. doi Clinical significance of miR-146a in gastric cancer cases
    Ryunosuke Kogo
    Department of Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Clin Cancer Res 17:4277-84. 2011
  10. pmc An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells
    Walter J Lukiw
    Louisiana State University Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112 2272, USA
    J Biol Chem 283:31315-22. 2008

Research Grants

  1. Gene Expression in Alzheimer's Disease
    Walter Lukiw; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications117 found, 100 shown here

  1. pmc NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    Konstantin D Taganov
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:12481-6. 2006
    ....
  2. doi MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins
    Yuanjia Tang
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, China
    Arthritis Rheum 60:1065-75. 2009
    ..This study was undertaken to investigate the contribution of microRNA-146a (miR-146a), which was identified in the pilot expression profiling step, to the pathogenesis of systemic lupus erythematosus (SLE)...
  3. doi Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case-control studies
    Jun Wang
    Department of Oncology, General Hospital, Jinan Command of the People s Liberation Army, Shifan Street 25, Tianqiao District, Jinan, 250031, China
    Mol Biol Rep 39:4571-9. 2012
    ..However, further well-designed studies with large sample size will be necessary to validate the risk identified in the current meta-analysis...
  4. doi An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes
    Graziella Curtale
    Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Universita di Roma, Rome, Italy
    Blood 115:265-73. 2010
    ..Furthermore, miR-146a enforced expression impairs both activator protein 1 (AP-1) activity and interleukin-2 (IL-2) production induced by TCR engagement, thus suggesting a role of this miRNA in the modulation of adaptive immunity...
  5. pmc CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells
    Slava Rom
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, PA 19122, USA
    FASEB J 24:2292-300. 2010
    ....
  6. pmc Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling
    Md A Nahid
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    J Immunol 186:1723-34. 2011
    ..Our studies have thus demonstrated that miR-146a plays a crucial role for in vitro monocytic cell-based endotoxin-induced cross-tolerance...
  7. doi A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis
    Jie Shen
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 29:1963-6. 2008
    ....
  8. pmc Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease
    Jian Guo Cui
    Department of Ophthalmology, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 285:38951-60. 2010
    ..The combinatorial use of NF-κB inhibitors with miRNA-146a or antisense miRNA-146a may have potential as a bi-pronged therapeutic strategy directed against IRAK-2-driven pathogenic signaling...
  9. doi Clinical significance of miR-146a in gastric cancer cases
    Ryunosuke Kogo
    Department of Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Clin Cancer Res 17:4277-84. 2011
    ..We investigated the clinical significance of miR-146a in gastric cancer, in particular focusing on hypothetical miR-146a target genes, such as epidermal growth factor receptor (EGFR) and interleukin-1 receptor-associated kinase (IRAK1)...
  10. pmc An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells
    Walter J Lukiw
    Louisiana State University Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112 2272, USA
    J Biol Chem 283:31315-22. 2008
    ....
  11. doi Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype
    Daniel T Starczynowski
    British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada
    Nat Med 16:49-58. 2010
    ..Thus, inappropriate activation of innate immune signals in HSPCs phenocopies several clinical features of 5q- syndrome...
  12. pmc Pharmacological studies of the mechanism and function of interleukin-1beta-induced miRNA-146a expression in primary human airway smooth muscle
    Hanna M Larner-Svensson
    Airway Disease, National Heart and Lung Institute, Imperial College London, London, UK
    Respir Res 11:68. 2010
    ..We have therefore examined the role of miR-146a during the interleukin (IL)-1beta-stimulated IL-6 and IL-8 release and proliferation in primary human airway smooth muscle (HASM) cells...
  13. doi Association study of common genetic variants in pre-microRNAs in patients with ulcerative colitis
    Masaaki Okubo
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Clin Immunol 31:69-73. 2011
    ..We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population...
  14. doi MicroRNA-146a is down-regulated in gastric cancer and regulates cell proliferation and apoptosis
    Zhibo Hou
    The Comprehensive Cancer Center of Drum Tower Hospital, Nanjing Medical University, Zhongshan Road 321, Nanjing 210008, People s Republic of China
    Med Oncol 29:886-92. 2012
    ..9 vs. 5.9%). Our results suggested that miR-146a has potential as a novel suppressor gene in gastric cancer and its down-regulation may promote the progression of gastric cancer...
  15. pmc Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck
    Zhensheng Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:4753-60. 2010
    ..The authors hypothesized that common polymorphisms in pre-miRNAs are associated individually and (more likely) collectively with the risk of squamous cell carcinoma of the head and neck (SCCHN)...
  16. pmc Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways
    Jennifer E Cameron
    Tulane University Health Sciences Center, 1430 Tulane Ave, SL79, New Orleans, LA 70112, USA
    J Virol 82:1946-58. 2008
    ....
  17. doi Combined effect of miR-146a rs2910164 G/C polymorphism and Toll-like receptor 4 +3725 G/C polymorphism on the risk of severe gastric atrophy in Japanese
    Asahi Hishida
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Dig Dis Sci 56:1131-7. 2011
    ..A G/C polymorphism in miRNA-146a (rs2910164) was shown to be associated with the risk of hepatocellular carcinoma...
  18. doi Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
    Joanna Stanczyk
    Center of Experimental Rheumatology, University Hospital Zurich, and Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Arthritis Rheum 58:1001-9. 2008
    ..In this study we investigated the expression, regulation, and function of miR-155 and miR-146a in rheumatoid arthritis (RA) synovial fibroblasts (RASFs) and RA synovial tissue...
  19. pmc The role of microRNA genes in papillary thyroid carcinoma
    Huiling He
    Human Cancer Genetics Program, Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 102:19075-80. 2005
    ..We conclude that up-regulation of several miRs and regulation of KIT are involved in PTC pathogenesis, and that sequence changes in genes targeted by miRNAs can contribute to their regulation...
  20. pmc MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?
    Eniko Sonkoly
    Dermatology and Venereology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 2:e610. 2007
    ..Taken together, a new layer of regulatory mechanisms is involved in the pathogenesis of chronic inflammatory skin diseases...
  21. pmc Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells
    Mark M Perry
    Biopharmaceutics Research Group, Airways Disease, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Immunol 180:5689-98. 2008
    ..Overall, these studies indicate that rapid increase in miRNA-146a expression provides a novel mechanism for the negative regulation of severe inflammation during the innate immune response...
  22. pmc Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma
    Krystian Jazdzewski
    Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, 850 Biomedical Research Tower, 460 West 12th Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 105:7269-74. 2008
    ..Preliminary evidence suggests that these effects are mediated through target genes whose expression is affected by the SNP status...
  23. doi A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis
    Catherine Labbaye
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, 00161 Rome, Italy
    Nat Cell Biol 10:788-801. 2008
    ..Our data indicate that megakaryopoiesis is controlled by a cascade pathway, in which PLZF suppresses miR-146a transcription and thereby activates CXCR4 translation...
  24. doi A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma
    Teng Xu
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Guangzhou 510275, People s Republic of China
    Carcinogenesis 29:2126-31. 2008
    ..Our findings warrant further investigations on the relation between microRNA polymorphism and human diseases...
  25. pmc Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
    Kaleb M Pauley
    Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
    Arthritis Res Ther 10:R101. 2008
    ..In this study, the expression of selected microRNAs is examined in rheumatoid arthritis...
  26. pmc MicroRNA miR-146a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytes
    Klemens Pichler
    Institute of Clinical and Molecular Virology, University Erlangen Nuremberg, Schlossgarten 4, Erlangen, Germany
    Retrovirology 5:100. 2008
    ..Affecting e.g. proliferation, microRNAs constitute a potential target for viral interference on the way to persistence and transformation. Hence, we explored the interconnections between HTLV-1 and cellular microRNAs...
  27. pmc Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis
    Douglas R Hurst
    Department of Pathology, Comprehensive Cancer Center, and National Foundation for Cancer Research, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Cancer Res 69:1279-83. 2009
    ..These results further support the recent notion that modulating the levels of miR-146a or miR-146b could have a therapeutic potential to suppress breast cancer metastasis...
  28. pmc miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY
    Md A Nahid
    Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 284:34590-9. 2009
    ..Thus our studies demonstrated that miR-146a is critical for the in vitro monocytic cell-based endotoxin tolerance...
  29. doi Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases
    Irene Catucci
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    Hum Mutat 31:E1052-7. 2010
    ..None of the performed analyses showed statistically significant results. In conclusion, our data suggested lack of association between SNPs rs2910164, rs11614913 and rs3746444 and breast cancer risk, or age at breast cancer onset...
  30. doi A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo
    Bin Xu
    Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Prostate 70:467-72. 2010
    ....
  31. doi miR-146a induces differentiation of periodontal ligament cells
    P S Hung
    Institute of Oral Biology, National Yang Ming University, No 155, Li Nong St, Sec 2, Taipei, Taiwan
    J Dent Res 89:252-7. 2010
    ..This study concludes that miR-146a promotes the differentiation in PDL cells through the down-regulation of NF-kappaB signaling...
  32. doi Serum miR-146a and miR-223 as potential new biomarkers for sepsis
    Jia Feng Wang
    Department of Anesthesiology and Intensive Care Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Biochem Biophys Res Commun 394:184-8. 2010
    ..Circulating microRNAs (miRNAs) are promising biomarkers for several diseases, but their correlation with sepsis is not totally clarified...
  33. doi Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Neurosci 31:1100-7. 2010
    ....
  34. doi MicroRNA-146a and human disease
    L Li
    Department of Pharmacology, School of Pharmaceutical Science, Central South University, Changsha, Hunan, China
    Scand J Immunol 71:227-31. 2010
    ..Potential use of miR-146a as a biomarker for disease diagnosis, prevention and treatment is also discussed...
  35. doi Altered microRNAs in STHdh(Q111)/Hdh(Q111) cells: miR-146a targets TBP
    Mithun Sinha
    Structural Genomics Section, Saha Institute of Nuclear Physics, 1 AF Bidhan Nagar, Kolkata 700 064, India
    Biochem Biophys Res Commun 396:742-7. 2010
    ..Using luciferase reporter assays with 3'-UTRs of TBP, over-expression and inhibition of miR-146a, we showed that miR-146a targets TBP. Regulation of TBP by miR-146a may contribute to HD pathogenesis...
  36. doi The role of microRNA-146a (miR-146a) and its target IL-1R-associated kinase (IRAK1) in psoriatic arthritis susceptibility
    A Chatzikyriakidou
    Genetics Unit, Department of Obstetrics and Gynaecology, Medical School, University of Ioannina, Ioannina, Greece
    Scand J Immunol 71:382-5. 2010
    ..394). This is the first study that addresses IRAK1 rs3027898 polymorphism association with PsA susceptibility, but further studies could help to understand the extent of the proposed association...
  37. doi The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis
    Lin Bo Gao
    Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China
    Breast Cancer Res Treat 125:571-4. 2011
    ..These findings suggest that has-miR-196a2 rs11614913 polymorphism may play crucial roles in breast cancer development...
  38. pmc Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population
    Ying Zeng
    Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
    World J Gastroenterol 16:3578-83. 2010
    ..To investigate the association between pre-miR-146a C/G polymorphism and gastric cancer risk...
  39. doi A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han
    Hong Guo
    Department of Medical Genetics, College of Basic Medical Science, Third Military Medical University, 400038 Chongqing, People s Republic of China
    Fam Cancer 9:599-603. 2010
    ..01). These findings suggest that this functional SNP in pre-miR-146a could contribute to ESCC susceptibility and clinical outcome...
  40. doi Association between hsa-mir-146a genotype and tumor age-of-onset in BRCA1/BRCA2-negative familial breast and ovarian cancer patients
    Chiara Pastrello
    Unit of Experimental Oncology 1, Department of Molecular Oncology and Translational Research, Centro di Riferimento Oncologico, CRO Aviano National Cancer Institute, 33081 Aviano, Italy
    Carcinogenesis 31:2124-6. 2010
    ....
  41. doi Genetic variation in microRNA genes and prostate cancer risk in North Indian population
    Ginu P George
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014 Uttar Pradesh, India
    Mol Biol Rep 38:1609-15. 2011
    ..We genotyped SNPs hsa-mir196a2 (rs11614913), hsa-mir146a (rs2910164), and hsa-mir499 (rs3746444) in a case-control study including 159 prostate cancer patients and 230 ..
  42. doi Association between common genetic variants in pre-microRNAs and gastric cancer risk in Japanese population
    Masaaki Okubo
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Helicobacter 15:524-31. 2010
    ....
  43. doi MicroRNA-146a regulates the maturation process and pro-inflammatory cytokine secretion by targeting CD40L in oxLDL-stimulated dendritic cells
    Ting Chen
    Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China
    FEBS Lett 585:567-73. 2011
    ..Our study clearly revealed that miRNA-146a regulates the maturation process and pro-inflammatory cytokine secretion in DCs by targeting CD40L in ox-LDL-stimulated DCs...
  44. doi Investigative role of pre-microRNAs in bladder cancer patients: a case-control study in North India
    Rama Devi Mittal
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India
    DNA Cell Biol 30:401-6. 2011
    ..This could further provide new prospects for understanding the underlying mechanisms between miRNAs and disease etiology...
  45. pmc Altered miR-146a expression in Sjögren's syndrome and its functional role in innate immunity
    Kaleb M Pauley
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, USA
    Eur J Immunol 41:2029-39. 2011
    ..Taken together, our data suggest that abnormal expression/regulation of microRNAs in innate immunity may contribute to, or be indicative of, the initiation and progression of SjS...
  46. pmc Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers
    Amandine I Garcia
    CNRS UMR5286 Inserm U1052, Equipe Labellisée LIGUE 2008, University Lyon, Cancer Research Center of Lyon, Centre Leon Berard, France
    EMBO Mol Med 3:279-90. 2011
    ..This work provides further evidence for the involvement of miRNAs in sporadic breast cancer through down-regulation of BRCA1...
  47. doi Polymorphism of the pre-miR-146a is associated with risk of cervical cancer in a Chinese population
    Cong Yue
    Department of Gynecology and Obstetrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
    Gynecol Oncol 122:33-7. 2011
    ..We hypothesized that a possible association exists between miR-146a gene polymorphisms and cervical cancer risk in a population-based control study of female residents in Jiangsu Province...
  48. pmc miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
    Mark P Boldin
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Med 208:1189-201. 2011
    ..Collectively, our findings suggest that miR-146a plays a key role as a molecular brake on inflammation, myeloid cell proliferation, and oncogenic transformation...
  49. doi MicroRNA-146a downregulates NFκB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma
    Jin Ho Paik
    Department of Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea
    Clin Cancer Res 17:4761-71. 2011
    ..We investigated prognostic implications of microRNAs in extranodal NK/T cell lymphoma (NKTL)...
  50. ncbi [Relationship between genetic polymorphism in microRNAs precursor and genetic predisposition of hepatocellular carcinoma]
    Xin wei Zhang
    Interventional Radiological Section, Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Zhonghua Yu Fang Yi Xue Za Zhi 45:239-43. 2011
    ..To investigate the relationship between genetic polymorphism in microRNAs (miRNAs) precursor and genetic predisposition of hepatocellular carcinoma (HCC) in Chinese population...
  51. pmc Effects of common polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on cancer susceptibility: a meta-analysis
    Wei Xu
    Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    PLoS ONE 6:e20471. 2011
    ..Rs11614913 in miR-196a2 and rs2910164 in miR-146a are shown to associate with increased/decreased cancer risk. We performed a meta-analysis to systematically summarize the possible association...
  52. pmc A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus
    Xiaobing Luo
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China
    PLoS Genet 7:e1002128. 2011
    ..Our data identified and confirmed an association between a functional promoter variant of miR-146a and SLE. This risk allele had decreased binding to transcription factor Ets-1, contributing to reduced levels of miR-146a in SLE patients...
  53. pmc A functional polymorphism in the pre-miR-146a gene is associated with risk and prognosis in adult glioma
    Jennifer Permuth-Wey
    Department of Cancer Epidemiology, Division of Population Sciences, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC CANCONT, Tampa, FL 33612 9416, USA
    J Neurooncol 105:639-46. 2011
    ..17, P = 0.002)). We provide novel data suggesting rs2910164 genotype may contribute to glioma susceptibility and outcome. Future studies are warranted to replicate these findings and characterize mechanisms underlying these associations...
  54. doi No association of pre-microRNA-146a rs2910164 polymorphism and risk of hepatocellular carcinoma development in Turkish population: a case-control study
    Hikmet Akkiz
    Cukurova University, Faculty of Medicine, Department of Gastroenterology, Adana, Turkey
    Gene 486:104-9. 2011
    ..A G/C polymorphism (rs2910164), which is located in the sequence of miR-146a precursor, results in a change from G:U to C:U in its stem region...
  55. pmc Association between two genetic variants in miRNA and primary liver cancer risk in the Chinese population
    Juan Zhou
    Division of Molecular Medicine, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, People s Republic of China
    DNA Cell Biol 31:524-30. 2012
    ..60 vs. 6.15, p=0.026). Our data suggested lack of association between the two SNPs and primary liver cancer risk, though, interestingly, the miR-146a SNP may influence the age of onset and Child-Pugh grade...
  56. doi H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells
    Na Li
    Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, Third Military Medical University, Chongqing, 400038, People s Republic of China
    Mol Biol Rep 39:4655-61. 2012
    ..pylori infection, while CagA is not necessarily required for miR-146a induction. miR-146a may function as novel negative regulators to modulate the inflammation...
  57. doi Changes in microRNA expression in peripheral mononuclear cells according to the progression of osteoarthritis
    Atsushi Okuhara
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Mod Rheumatol 22:446-57. 2012
    ..This evidence could lead to the elucidation of the mechanism underlying OA pathogenesis and hence to a novel therapeutic strategy for OA...
  58. doi Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis
    Bin Xiao
    Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, Third Military Medical University, and Department of Pharmacy, Southwest Hospital, Chongqing 400038, PR China
    Oncol Rep 27:559-66. 2012
    ..miR-146a could serve as a potential biomarker and therapeutic target against gastric cancer...
  59. pmc Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome
    W J Lukiw
    LSU Neuroscience Center and Departments of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA70112 2272, USA
    J Toxicol Environ Health A 74:1460-8. 2011
    ....
  60. pmc Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene
    S E Löfgren
    Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Genes Immun 13:268-74. 2012
    ..We replicated the genetic association of rs2341697 with SLE in a case-control study in Europeans and demonstrated that the risk allele of this SNP correlates with a downregulation of the miRNA 146a, potentially important in SLE etiology...
  61. pmc Lack of association of miR-146a and Ets-1 gene polymorphisms with Fuchs uveitis syndrome in Chinese Han patients
    Qingyun Zhou
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing, P R China
    Mol Vis 18:426-30. 2012
    ..The aim of this study was to investigate the potential association of microRNA-146a (miR-146a) and V-Ets oncogene homolog 1 (Ets-1) gene polymorphisms with Fuchs Uveitis syndrome (FUS)...
  62. pmc The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer
    Catherine Labbaye
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Hematol Oncol 5:13. 2012
    ..Finally, many recent studies indicate a deregulation of miR-146 in many solid tumors and gene knockout studies indicate a role for this miRNA as a tumor suppressor...
  63. doi A functional polymorphism in Pre-miR-146a is associated with susceptibility to gastric cancer in a Chinese population
    Fengying Zhou
    Department of Surgery, Yixing Cancer Hospital, Yixing, China
    DNA Cell Biol 31:1290-5. 2012
    ..51, 95% CI = 1.25-1.81) rather than in older subjects. Our results suggest that the rs2910164 polymorphism in the sequence of miR-146a precursor may influence the susceptibility to gastric cancer in our Chinese population...
  64. doi Association of MicroRNA-146a with autoimmune diseases
    Wang Dong Xu
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People s Republic of China
    Inflammation 35:1525-9. 2012
    ..In this review, emphasis will be laid on the recent progress in the functional roles of miR-146a in these autoimmune diseases...
  65. doi A single nucleotide polymorphism in microRNA-146a is associated with the risk for nasopharyngeal carcinoma
    Raymond Wai Ming Lung
    Department of Anatomical and Cellular Pathology at Li Ka Shing Institute of Health Sciences, Sir Y K Pao Center for Cancer, State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Hong Kong SAR, China
    Mol Carcinog 52:E28-38. 2013
    ..These findings may enrich our understanding of how miRNA single nucleotide polymorphism affect NPC pathogenesis, and may have potential implications to improve NPC treatment in the future...
  66. ncbi Meta-analysis confirms that a common G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors
    A X Wang
    Department of Urology, JingDu Hospital of Nanjing, Nanjing, China
    Genet Mol Res 11:3051-62. 2012
    ..01-1.53). We conclude that there is evidence that the pre-miR-146a polymorphism contributes to cancer susceptibilities and that gender and smoking status affect the probability of cancer in individuals with this polymorphism...
  67. pmc MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response
    Anand Iyer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e44789. 2012
    ..Modulation of miR-146a expression by transfection of astrocytes with anti-miR146a or mimic, regulated the mRNA expression levels of downstream targets of miR-146a (IRAK-1, IRAK-2 and TRAF-6) and ..
  68. doi Association of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk
    Young Joo Jeon
    Institute for Clinical Research, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea
    Arterioscler Thromb Vasc Biol 33:420-30. 2013
    ..However, the effect of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms on stroke and silent brain infarction (SBI) susceptibility has not been reported...
  69. ncbi Association of pre-miR-146a rs2910164 Polymorphism with the Risk of Head and Neck Cancer
    Zsuzsa Orsos
    7624 Pecs, Szigeti str 12 Hungary
    Anticancer Res 33:341-6. 2013
    ..The aim of the present study was to investigate the possible influence of the pre-miR-146a rs2910164 polymorphism on the risk of squamous cell carcinoma of the head and neck (HNSCC)...
  70. doi A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population
    Lan Ma
    Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
    Arch Toxicol 87:825-33. 2013
    ..93). In conclusion, our results suggest that miR-146a rs2910164 may contribute to the susceptibility to CRC in a Chinese population. Further larger population-based prospective and functional studies are needed to validate our findings...
  71. ncbi The miR-146a rs2910164 G > C polymorphism and susceptibility to digestive cancer in Chinese
    Dong Wu
    Department of Gastroenterology, Shanghai Tenth People s Hospital, Tongji University School of Medicine, Shanghai, China
    Asian Pac J Cancer Prev 14:399-403. 2013
    ..However, the results have been controversial. Therefore, we conducted the present meta-analysis to obtain the most reliable estimate of the association...
  72. doi Association between miR-146a rs2910164 polymorphism and autoimmune diseases susceptibility: a meta-analysis
    Hui Fang Chen
    Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China
    Gene 521:259-64. 2013
    ..Our meta-analysis suggests that there is no association between miR-146a G/C rs2910164 polymorphism and the development of autoimmune diseases...
  73. pmc miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells
    Gang Chen
    Department of Pathology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People s Republic of China
    PLoS ONE 8:e60317. 2013
    ..6 weeks in miR-146a high patients vs. 4.8 weeks in miR-146a low patients, P<0.05). miR-146a is therefore a strong candidate prognostic biomarker in NSCLC. Thus inducing miR-146a might be a therapeutic strategy for NSCLC...
  74. doi MicroRNA gene polymorphisms in pancreatic cancer
    Emmanouel Pavlakis
    2nd Department of Surgery, Areteion Hospital, School of Medicine, University of Athens, Athens, Greece
    Pancreatology 13:273-8. 2013
    ....
  75. doi Genetic polymorphisms in pre-microRNAs and risk of ischemic stroke in a Chinese population
    Yun Liu
    Department of Forensic Medicine, North Shichuan Medical College, Nanchong, 637000, People s Republic of China
    J Mol Neurosci 52:473-80. 2014
    ....
  76. ncbi Association between single nucleotide polymorphisms in miRNA196a-2 and miRNA146a and susceptibility to hepatocellular carcinoma in a Chinese population
    Jun Zhang
    Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, China E mail
    Asian Pac J Cancer Prev 14:6427-31. 2013
    ..In particular, the association between SNPs in miRNA196a-2 (rs11614913) and miRNA146a (rs2910164) and HCC has been investigated...
  77. doi Analysis of miRNA expression profiling in human macrophages responding to Mycobacterium infection: induction of the immune regulator miR-146a
    Zhen Liu
    Institute of Tuberculosis Research, The 309th Hospital of PLA, Beijing 100091, China
    J Infect 68:553-61. 2014
    ..The regulatory mechanism of microRNA (miRNA) within macrophage innative response to Mycobacterium tuberculosis infection is not clear yet...
  78. doi MicroRNA-146a rs2910164 polymorphism is associated with susceptibility to non-small cell lung cancer in the Chinese population
    Youchao Jia
    Department of Oncology, Affiliated Hospital of Hebei University, 212 Yuhua East Road, Baoding, Hebei, People s Republic of China
    Med Oncol 31:194. 2014
    ..0022). It confirmed that the SNP rs2910164 could functionally affect the miR-146a expression levels. In conclusion, it showed that the rs2910164 polymorphism of miR-146a is associated with the risk of NSCLC in the Chinese population...
  79. pmc Involvement of inflammation-related miR-155 and miR-146a in diabetic nephropathy: implications for glomerular endothelial injury
    Youqun Huang
    Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
    BMC Nephrol 15:142. 2014
    ..In this study, we investigated both the repertoire of miRNAs in the kidneys of patients with DN and their potential regulatory role in inflammation-mediated glomerular endothelial injury...
  80. doi MicroRNA-146a modulates human bronchial epithelial cell survival in response to the cytokine-induced apoptosis
    Xiangde Liu
    Pulmonary, Critical Care, Sleep and Allergy Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Biochem Biophys Res Commun 380:177-82. 2009
    ..The MicroRNA-146a mimic appears to modulate HBEC survival through a mechanism of up-regulating Bcl-XL and STAT3 phosphorylation, and by this mechanism it could contribute to tissue repair and remodeling...
  81. pmc Expression of MicroRNA-146a in osteoarthritis cartilage
    Keiichiro Yamasaki
    Hiroshima University, Hiroshima, Japan
    Arthritis Rheum 60:1035-41. 2009
    ..The objective of this study was to identify the expression pattern of microRNA-146a (miR-146a) in cartilage from patients with osteoarthritis (OA)...
  82. doi miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation
    Jennifer Jurkin
    Center of Physiology, Pathophysiology and Immunology, Institute of Immunology, Center of Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    J Immunol 184:4955-65. 2010
    ....
  83. pmc MicroRNA-146a is upregulated by and negatively regulates TLR2 signaling
    Edel M Quinn
    Department of Academic Surgery, University College Cork, Cork University Hospital, Cork, Ireland
    PLoS ONE 8:e62232. 2013
    ..Overexpression of miR-146a induces a state analogous to tolerance in BLP-stimulated cells and therefore may represent a future target for exogenous modulation of tolerance during microbial infection and sepsis...
  84. pmc MicroRNA-146a regulates survival and maturation of human plasmacytoid dendritic cells
    Julien J Karrich
    Department of Cell Biology and Histology and
    Blood 122:3001-9. 2013
    ..Our data unravel the crucial immunomodulatory role of miR-146a in pDCs and may add to our understanding of aberrant responses in autoimmune diseases. ..
  85. doi Expression of MicroRNA-146a in peripheral blood mononuclear cells in patients with systemic lupus erythematosus
    Wang Hai-Yan
    Department of Rheumatology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 33:185-8. 2011
    ..To explore the expression pattern of microRNAs in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), with an attempt to identify the role of microRNA in the pathogenesis of SLE...
  86. doi MiR-146a negatively regulates neutrophil elastase-induced MUC5AC secretion from 16HBE human bronchial epithelial cells
    Tian Zhong
    Department of Respiratory Medicine, The Second Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400010, China
    Mol Cell Biochem 358:249-55. 2011
    ..Taken together, our data highlight a negative feedback role for miR-146a in the control of MUC5AC production from airway epithelial cells stimulated by NE, which may be associated with the inactivation of JNK and NF-κB signaling...
  87. doi MicroRNA 146a expression in rheumatoid arthritis: association with tumor necrosis factor-alpha and disease activity
    Abla Abou-Zeid
    Department of Clinical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
    Genet Test Mol Biomarkers 15:807-12. 2011
    ..Disease activity of RA was assessed using disease activity score (DAS) 28 and physical disability using the Improved Health Assessment Questionnaire...
  88. doi MiR-146a suppresses tumor growth and progression by targeting EGFR pathway and in a p-ERK-dependent manner in castration-resistant prostate cancer
    Bin Xu
    Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China
    Prostate 72:1171-8. 2012
    ..Given the emerging roles of microRNA (miRNA) as a key regulator, we postulated that miRNA may play a significant role in CRPC formation...
  89. doi Association between the rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression
    Pei Shi Hung
    Institute of Oral Biology, School of Dentistry, National Yang Ming University, Taipei, Taiwan
    Oral Oncol 48:404-8. 2012
    ..The present study concluded a higher prevalence of the pre-mir-146a C-variant was associated with OSCC progression in patients with this disease...
  90. doi Aberrant elevated microRNA-146a in dendritic cells (DC) induced by human pancreatic cancer cell line BxPC-3-conditioned medium inhibits DC maturation and activation
    Jian Du
    Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, No 222, Zhongshan Road, Dalian, 116011, People s Republic of China
    Med Oncol 29:2814-23. 2012
    ....
  91. doi Porphyromonas gingivalis lipopolysaccharide induces miR-146a without altering the production of inflammatory cytokines
    Tomoyuki Honda
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    Biochem Biophys Res Commun 420:918-25. 2012
    ..gingivalis LPS. Because TLR signaling induces various negative regulators, these results call into question the role of miR-146a in cells stimulated with TLR ligands...
  92. pmc Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer
    Renata Hezova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech
    World J Gastroenterol 18:2827-31. 2012
    ..To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-196a2, miR-27a and miR-146a genes are associated with sporadic colorectal cancer (CRC)...
  93. doi Expression of miRNA-146a in nasopharyngeal carcinoma is upregulated by Epstein-Barr virus latent membrane protein 1
    Yinghai Zhao
    Department of Pathology, Guangdong Medical College, Zhanjiang 524023, PR China
    Oncol Rep 28:1237-42. 2012
    ..01). The expression of miRNA-146a in human NPC was elevated by EBV-associated antigen LMP1, probably through the activation of the miRNA-146a promoter...
  94. ncbi A common variant in the precursor miR-146a sequence does not predispose to cholangiocarcinoma in a large European cohort
    Florentina Mihalache
    Department of Medicine II, Saarland University Hospital, Homburg 66421, Germany
    Hepatobiliary Pancreat Dis Int 11:412-7. 2012
    ..We investigated rs2910164 in a large European-based cholangiocarcinoma (CCA) cohort...
  95. pmc Association between the rs2910164 polymorphism in pre-Mir-146a sequence and thyroid carcinogenesis
    Wen jun Wei
    Department of Head and Neck Surgery, Cancer Hospital, Fudan University, Shanghai, China
    PLoS ONE 8:e56638. 2013
    ..This study evaluated the association between rs2910164 and the risk of PTC as well as benign thyroid tumor (BN), and examined the clinicopathological characteristics of PTC and BN for different genotypes...
  96. pmc Differential regulation of microRNA-146a and microRNA-146b-5p in human retinal pigment epithelial cells by interleukin-1β, tumor necrosis factor-α, and interferon-γ
    R Krishnan Kutty
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Vis 19:737-50. 2013
    ..The aim of the present study is to investigate the expression of miR-146a and miR-146b-5p in human RPE cells and their response to proinflammatory cytokines...
  97. pmc Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
    Xuezhong Cai
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 102:5570-5. 2005
    ..We hypothesize that these viral miRNAs play a critical role in the establishment and/or maintenance of KSHV latent infection in vivo and, hence, in KSHV-induced oncogenesis...
  98. doi Novel genetic variants in microRNA genes and familial breast cancer
    Jie Shen
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 124:1178-82. 2009
    ..Our findings suggest that functional genetic variants in miRNA genes can potentially alter the regulation of key breast cancer genes. Whether they confer genetic susceptibility to breast cancer remains to be determined...
  99. doi Characterization of an NF-kappaB-regulated, miRNA-146a-mediated down-regulation of complement factor H (CFH) in metal-sulfate-stressed human brain cells
    Aileen I Pogue
    Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Inorg Biochem 103:1591-5. 2009
    ....
  100. doi Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis
    Meilin Wang
    Department of Occupational Medicine and Environmental Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing, China
    J Hum Genet 55:13-7. 2010
    ..50, 95% CI=1.05-2.14 for stage II, and OR=3.33, 95% CI=1.67-6.65 for stage III). These results suggest that miR-149 rs2292832 polymorphism is involved in susceptibility to developing CWP...
  101. doi Identification of the potential target genes of microRNA-146a induced by PMA treatment in human microvascular endothelial cells
    Ching Hua Hsieh
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Exp Cell Res 316:1119-26. 2010
    ....

Research Grants1

  1. Gene Expression in Alzheimer's Disease
    Walter Lukiw; Fiscal Year: 2006
    ..abstract_text> ..