MIR155

Summary

Gene Symbol: MIR155
Description: microRNA 155
Alias: MIRN155, miRNA155
Species: human

Top Publications

  1. doi miR-155 gene: a typical multifunctional microRNA
    Isabella Faraoni
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Biochim Biophys Acta 1792:497-505. 2009
  2. pmc Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathway
    Graziana Gatto
    Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Naples, Italy
    Nucleic Acids Res 36:6608-19. 2008
  3. pmc Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas
    Irene M Pedersen
    Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA
    EMBO Mol Med 1:288-95. 2009
  4. pmc The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding
    Mickey M Martin
    Davis Heart and Lung Institute, The Ohio State University, Ohio 43210, USA
    J Biol Chem 282:24262-9. 2007
  5. doi MicroRNA-155 may affect allograft survival by regulating the expression of suppressor of cytokine signaling 1
    Maomao Zhang
    Key Laboratories of Education, Ministry for Myocardial Ischemia Mechanism and Treatment, Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province 150081, China
    Med Hypotheses 77:682-4. 2011
  6. doi Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155
    D W Lee
    Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Oncogene 31:4085-94. 2012
  7. doi Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt activation and up-regulation of Mcl-1
    Joo Hyun Kim
    Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea
    Leuk Lymphoma 53:1586-91. 2012
  8. doi MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression
    Y S Zang
    Department of Respiratory Medicine, Changzheng Hospital, Second Military Medical University Center for Diagnosis and Treatment of Lung Cancer of the Chinese People s Liberation Army, Shanghai, China
    Cancer Gene Ther 19:773-8. 2012
  9. ncbi High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma
    Markus Metzler
    Genes Chromosomes Cancer 39:167-9. 2004
  10. pmc Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma
    Ji Kon Ryu
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Baltimore, MD, USA
    Pancreatology 10:66-73. 2010

Research Grants

  1. P13K/AKT crosstalk with ER-signaling and cell survival
    Matthew Burow; Fiscal Year: 2008
  2. Transformation of Cells by the REL Oncogene
    Thomas Gilmore; Fiscal Year: 2009
  3. HUMAN ANGIOTENSIN II RECEPTOR GENE REGULATION
    Terry Elton; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications104 found, 100 shown here

  1. doi miR-155 gene: a typical multifunctional microRNA
    Isabella Faraoni
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Biochim Biophys Acta 1792:497-505. 2009
    ..Exogenous molecular control in vivo of miR-155 expression could open up new ways to restrain malignant growth and viral infections, or to attenuate the progression of cardiovascular diseases...
  2. pmc Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathway
    Graziana Gatto
    Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Naples, Italy
    Nucleic Acids Res 36:6608-19. 2008
    ..Finally, we demonstrate that LMP1-mediated activation of miR-155 in an EBV-negative background correlates with reduction of protein PU.1, which is a possible miR target...
  3. pmc Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas
    Irene M Pedersen
    Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA
    EMBO Mol Med 1:288-95. 2009
    ....
  4. pmc The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding
    Mickey M Martin
    Davis Heart and Lung Institute, The Ohio State University, Ohio 43210, USA
    J Biol Chem 282:24262-9. 2007
    ..Therefore, our study provides the first feasible biochemical mechanism by which the +1166 A/C polymorphism can lead to increased AT1R densities and possibly cardiovascular disease...
  5. doi MicroRNA-155 may affect allograft survival by regulating the expression of suppressor of cytokine signaling 1
    Maomao Zhang
    Key Laboratories of Education, Ministry for Myocardial Ischemia Mechanism and Treatment, Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province 150081, China
    Med Hypotheses 77:682-4. 2011
    ..Further studies on the specific role of miR-155 in allograft rejection may lead to the identification of new targets for therapeutic intervention...
  6. doi Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155
    D W Lee
    Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Oncogene 31:4085-94. 2012
    ..These data suggest that miR-155 and miR-210/SHIP-1/Akt pathways could serve as clinical biomarkers for disease progression, and that miR-155 and miR-210 might serve as novel therapeutic targets in MDS...
  7. doi Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt activation and up-regulation of Mcl-1
    Joo Hyun Kim
    Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea
    Leuk Lymphoma 53:1586-91. 2012
    ..Thus, we propose Akt and Mcl-1 and miR-155 as molecular targets for therapeutic intervention in the treatment of EBV-associated B-cell lymphoma with rituximab...
  8. doi MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression
    Y S Zang
    Department of Respiratory Medicine, Changzheng Hospital, Second Military Medical University Center for Diagnosis and Treatment of Lung Cancer of the Chinese People s Liberation Army, Shanghai, China
    Cancer Gene Ther 19:773-8. 2012
    ..In conclusion, the inhibition of miR-155 can enhance the sensitivity of A549 cells to cisplatin treatment by modulation of cellular apoptosis and DNA damage through an Apaf-1-mediated pathway...
  9. ncbi High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma
    Markus Metzler
    Genes Chromosomes Cancer 39:167-9. 2004
  10. pmc Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma
    Ji Kon Ryu
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Baltimore, MD, USA
    Pancreatology 10:66-73. 2010
    ..Misexpression of microRNAs (miRNAs) is commonly encountered in invasive neoplasia; however, miRNA abnormalities in PanIN lesions have not been documented...
  11. pmc Accumulation of miR-155 and BIC RNA in human B cell lymphomas
    Peggy S Eis
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:3627-32. 2005
    ..Because patients with activated B cell-type DLBCL have a poorer clinical prognosis, quantification of this microRNA may be diagnostically useful...
  12. ncbi BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas
    Joost Kluiver
    Department of Pathology and Laboratory Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    J Pathol 207:243-9. 2005
    ..Northern blot analysis showed expression of miR-155 in all DLBCL and PMBL derived cell lines and tissue samples analysed. In summary, we demonstrate expression of primary microRNA BIC and its derivative miR-155 in HL, PMBL and DLBCL...
  13. ncbi miR-155/BIC as an oncogenic microRNA
    Wayne Tam
    Genes Chromosomes Cancer 45:211-2. 2006
  14. ncbi MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts
    Mickey M Martin
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 281:18277-84. 2006
    ..Importantly, the translational repression mediated by miR-155 can be regulated by physiological stimuli...
  15. ncbi Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis
    S Marton
    Molecular Oncology Unit, Institut Pasteur, Montevideo, Uruguay
    Leukemia 22:330-8. 2008
    ..Predicted targets included several genes recently described as tumor suppressors. These data could afford new avenues for exploring innovative pathways in CLL biology and therapy...
  16. pmc B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element
    Qinyan Yin
    Department of Pathology, Tulane Health Sciences Center and Tulane Cancer Center, New Orleans, LA 70112, USA
    J Biol Chem 283:2654-62. 2008
    ..These results identify key determinants of BCR-mediated signaling that lead to the induction of BIC/miR-155...
  17. doi Kaposi's sarcoma herpes virus taps into a host microRNA regulatory network
    Lydia V McClure
    Molecular Genetics and Microbiology, The University of Texas at Austin, 1 University Station A5000, Austin, TX 78712 0162, USA
    Cell Host Microbe 3:1-3. 2008
    ..Two new papers provide strong evidence that a KSHV-encoded microRNA and mir-155 share a common set of mRNA targets and binding sites, implying a possible link between viral- and non-viral-mediated tumorigenesis...
  18. doi Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
    Joanna Stanczyk
    Center of Experimental Rheumatology, University Hospital Zurich, and Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Arthritis Rheum 58:1001-9. 2008
    ..In this study we investigated the expression, regulation, and function of miR-155 and miR-146a in rheumatoid arthritis (RA) synovial fibroblasts (RASFs) and RA synovial tissue...
  19. pmc Epstein-Barr virus-induced miR-155 attenuates NF-kappaB signaling and stabilizes latent virus persistence
    Fang Lu
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Virol 82:10436-43. 2008
    ..This suggests that miR-155 contributes to EBV immortalization by modulation of NF-kappaB signaling and the suppression of host innate immunity to latent viral infection...
  20. doi Latent membrane protein-1 of Epstein-Barr virus induces the expression of B-cell integration cluster, a precursor form of microRNA-155, in B lymphoma cell lines
    Nur Rahadiani
    Department of Pathology, Osaka University Graduate School of Medicine, 2 2Yamadoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 377:579-83. 2008
    ..These results suggest that BIC/miR-155 play a role in lymphomagenesis through NF-kappaB and p38/MAPK pathways in response to activation by EBV LMP1...
  21. pmc MicroRNA miR-155 is a biomarker of early pancreatic neoplasia
    Nils Habbe
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Biol Ther 8:340-6. 2009
    ..Misexpression of microRNAs (miRNAs) is commonly observed in pancreatic adenocarcinoma. In contrast, miRNA abnormalities in pancreatic cancer precursor lesions have not been documented...
  22. pmc MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells
    Maurizio Ceppi
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 106:2735-40. 2009
    ..Our observations suggest, therefore, that in mature human DCs, miR-155 is part of a negative feedback loop, which down-modulates inflammatory cytokine production in response to microbial stimuli...
  23. doi Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells
    Susan Kohlhaas
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    J Immunol 182:2578-82. 2009
    ..However, we found no evidence for defective suppressor activity of miR-155-deficient Tregs, either in vitro or in vivo. Our results indicate that miR-155 contributes to Treg development, but that additional miRNAs control Treg function...
  24. doi Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival
    Thomas Greither
    Clinic of Radiation Therapy, Martin Luther University, Halle, Wittenberg, Germany
    Int J Cancer 126:73-80. 2010
    ..Furthermore, the putative target genes for these microRNAs suggest a complex signaling network that can affect PDAC tumorigenesis and tumor progression...
  25. ncbi Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155
    Lauretta Levati
    Laboratory of Molecular Oncology, Istituto Dermopatico dell Immacolata IRCCS, I 00167 Rome, Italy
    Int J Oncol 35:393-400. 2009
    ..In conclusion, our data further support the finding of altered miRNA expression in melanoma cells and establish for the first time that miRNA-155 is a negative regulator of melanoma cell proliferation and survival...
  26. doi Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia
    Yasuo Yamanaka
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
    Blood 114:3265-75. 2009
    ..Collectively, these results provide important new insight into the pathogenesis of NK-cell lymphoma/leukemia and suggest targeting miR-21 and/or miR-155 may represent a useful approach to treating NK-cell lymphoma/leukemia...
  27. pmc MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPbeta
    Min He
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou, China
    Cell Mol Immunol 6:343-52. 2009
    ....
  28. pmc Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis
    Deepak Rai
    Division of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 107:3111-6. 2010
    ..Together, our data helped explain miR-155 function, highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology, and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects...
  29. doi Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation
    Bin Tang
    Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, Third Military Medical University, Chongqing, China
    FEBS Lett 584:1481-6. 2010
    ..pylori infection. Thus, we have demonstrated that miR-155 can negatively regulate inflammation by targeting a key adaptor molecule MyD88 in inflammatory pathways...
  30. doi MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene
    Shuai Jiang
    State Key Laboratory of Molecular Biology, Core Facility for Noncoding RNA, and Center of Cell Signaling, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Cancer Res 70:3119-27. 2010
    ..Taken together, our study reveals that miR-155 is an oncomiR in breast cancer and that miR-155 may be a potential target in breast cancer therapy...
  31. pmc MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer
    William Kong
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 285:17869-79. 2010
    ..In conclusion, our study reveals a molecular link between miR-155 and FOXO3a and presents evidence that miR-155 is a critical therapeutic target in breast cancer...
  32. ncbi [Expression and its clinical significance of miR-155 in human primary breast cancer]
    Jin Zhu
    Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
    Zhonghua Wai Ke Za Zhi 48:205-8. 2010
    ..To investigate the expression of the miR-155 in human primary breast cancer and its clinical significance...
  33. pmc MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1
    Jia Liu
    Department of Endocrinology, Provincial Hospital Shandong University, Jinan, China
    J Cell Mol Med 15:1474-82. 2011
    ..MiR-155 provides the opportunity to block necrosis, a conventionally thought non-regulated process, and might be a potential novel approach to improve cell engraftment for cell therapy...
  34. pmc Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus
    Sarah D Linnstaedt
    Department of Molecular Genetics and Microbiology, Durham, NC 27710, USA
    J Virol 84:11670-8. 2010
    ....
  35. pmc NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway
    Ryan C Thompson
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 286:1675-82. 2011
    ..1, and consequently reduced CD10 mRNA and protein...
  36. pmc Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway
    R Krishnan Kutty
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 402:390-5. 2010
    ..in STAT1 activation as well as an increase in protein binding to putative STAT1 binding elements present in the MIR155 gene promoter region. All these activities were effectively blocked by JAK inhibitor 1...
  37. pmc MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}
    Fethi Louafi
    JunkRNA Laboratory, Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Biol Chem 285:41328-36. 2010
    ..Altogether, our data uncover an important role for miR-155 in modulating the cellular response to TGF-β with possible implications in several human diseases where homeostasis of TGF-β might be altered...
  38. pmc The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1)
    Rocio T Martinez-Nunez
    JunkRNA Laboratory, Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Biol Chem 286:1786-94. 2011
    ..Our work shows a central role for miR-155 in determining the M2 phenotype in human macrophages...
  39. pmc Prognostic impact of MiR-155 in non-small cell lung cancer evaluated by in situ hybridization
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    J Transl Med 9:6. 2011
    ..MiR-155 is one of the miRNAs most consistently involved in various neoplastic diseases. We aimed to investigate the prognostic impact of the multifunctional miR-155 in non-small cell lung cancer (NSCLC) patients...
  40. pmc Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8
    Sharmistha Bhattacharyya
    Department of Health Systems, Risk, and Contingency Management, Graduate School of Nursing, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 286:11604-15. 2011
    ..These data suggest that miR-155 may play an important role in the activation of IL-8-dependent inflammation in CF...
  41. doi MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia
    Karin Vargova
    First Faculty of Medicine and Center of Experimental Hematology, Charles University in Prague, U nemocnice 5, Prague, Czech Republic
    Blood 117:3816-25. 2011
    ..Our data provide evidence of oncogenic activities of MYB in B-CLL that include its stimulatory role in MIR155HG transcription...
  42. pmc Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer
    Esmerina Tili
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 108:4908-13. 2011
    ..Hence, we anticipate that the development of drugs reducing endogenous miR-155 levels might be key in the treatment of inflammation-related cancers...
  43. doi Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function
    Isabelle Dunand-Sauthier
    Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Blood 117:4490-500. 2011
    ..There is growing evidence that microRNA-155 (miR155) modulates gene expression in various cell types of the immune system and is a prominent player in the regulation ..
  44. doi Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer
    Hajime Shibuya
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Oncology 79:313-20. 2010
    ..In this study, we established the prognostic value of miR-21 and miR-155 using clinical samples from CRC patients. Furthermore, relationships between these microRNAs and target genes (PDCD4 and TP53INP1 mRNAs) were examined...
  45. doi MicroRNA-155 targets the SKI gene in human melanoma cell lines
    Lauretta Levati
    Laboratory of Molecular Oncology, Istituto Dermopatico dell Immacolata IRCCS, Via dei Monti di Creta, Rome, Italy
    Pigment Cell Melanoma Res 24:538-50. 2011
    ..Our data demonstrate for the first time that SKI is a target of miR-155 in melanoma. However, impairment of SKI expression is not the leading mechanism involved in the growth-suppressive effect of miR-155 found in this malignancy...
  46. doi MicroRNA-155 is involved in the remodelling of human-trophoblast-derived HTR-8/SVneo cells induced by lipopolysaccharides
    Yimin Dai
    Department of Obstetrics and Gynecology, Nanjing University Medical School, Nanjing, People s Republic of China
    Hum Reprod 26:1882-91. 2011
    ..Our goal was to investigate the association of miR-155 with pre-eclampsia and the pathways involved using human-trophoblast-derived cell line (HTR-8/SVneo) stimulated with LPS...
  47. pmc Upregulation of MiR-155 in nasopharyngeal carcinoma is partly driven by LMP1 and LMP2A and downregulates a negative prognostic marker JMJD1A
    Zi Ming Du
    State Key Laboratory of Oncology in South China, and Department of Pathology, Sun Yat sen University Cancer Center, Guangzhou, PR China
    PLoS ONE 6:e19137. 2011
    ..The potential of miR-155 and JMJD1A as therapeutic targets in NPC should be further investigated...
  48. doi Role of microRNA-155 in autoimmunity
    Rui Xue Leng
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China
    Cytokine Growth Factor Rev 22:141-7. 2011
    ..Since pathogenic immune cells play a pivotal role in pathogenesis of human autoimmune diseases, miR-155 might be a versatile therapeutic target. This review will discuss the current understandings for the role of miR-155 in autoimmunity...
  49. doi Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222
    Magne Skårn
    Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Stem Cells Dev 21:873-83. 2012
    ....
  50. doi [Effects of microRNA-155 on the growth of human lung cancer cell line 95D 
in vitro]
    Andong Qin
    Department of Immunology, Zunyi Medical College, Zunyi 563003, China
    Zhongguo Fei Ai Za Zhi 14:575-80. 2011
    ....
  51. pmc Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors
    Kyriaki Bakirtzi
    Division of Digestive Diseases, Inflammatory Bowel Disease Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Gastroenterology 141:1749-61.e1. 2011
    ..MicroRNAs (miR) regulate protein synthesis by degrading or preventing translation of mRNAs. We analyzed expression of 365 different microRNAs by human colonic epithelial cells (NCM460) after activation of NTR1...
  52. pmc MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia
    Ulrike Bruning
    School of Medicine and Medical Science and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Mol Cell Biol 31:4087-96. 2011
    ....
  53. pmc A Kaposi's sarcoma-associated herpesvirus-encoded ortholog of microRNA miR-155 induces human splenic B-cell expansion in NOD/LtSz-scid IL2Rγnull mice
    Isaac W Boss
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, USA
    J Virol 85:9877-86. 2011
    ....
  54. doi Aberrant expression of microRNA 155 may accelerate cell proliferation by targeting sex-determining region Y box 6 in hepatocellular carcinoma
    Qing Xie
    Department of Microbiology and Infectious Disease Center, Peking University Health Science Center, Beijing, China
    Cancer 118:2431-42. 2012
    ..Recent research has suggested that the oncomir microRNA 155 (miR-155) is up-regulated in hepatocellular carcinoma (HCC). In this study, the authors investigated the tumorigenic mechanism of this oncomir in the development of HCC...
  55. pmc miR-155 regulates HGAL expression and increases lymphoma cell motility
    Liat Nadav Dagan
    Division of Hematology Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
    Blood 119:513-20. 2012
    ..Furthermore, this effect may contribute to lymphoma cell dissemination and aggressiveness, characteristic of activated B cell-like diffuse large B-cell lymphoma typically expressing high levels of miR-155 and lacking HGAL expression...
  56. doi Clinical significance of microRNA-155 expression in human breast cancer
    Jian Chen
    Department of General Surgery, The First Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China
    J Surg Oncol 106:260-6. 2012
    ..The aim of this study is to investigate clinical significance of miR-155 expression in breast cancer...
  57. pmc Clinical significance of miR-155 expression in breast cancer and effects of miR-155 ASO on cell viability and apoptosis
    Shu rong Zheng
    Department of Oncology, The First Affiliated Hospital of Wenzhou Medical College, Zhejiang 325000, PR China
    Oncol Rep 27:1149-55. 2012
    ..The Annexin V-FITC/PI assay also indicated that transfection with miR-155 ASO promoted apoptosis...
  58. doi MiR-155 negatively regulates c-Jun expression at the post-transcriptional level in human dermal fibroblasts in vitro: implications in UVA irradiation-induced photoaging
    Jianwen Song
    Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an
    Cell Physiol Biochem 29:331-40. 2012
    ..We undertook this study to investigate whether microRNA-155 (miR-155) directly regulates the expression of c-Jun in HDFs in vitro...
  59. pmc Downregulation of miR-31, miR-155, and miR-564 in chronic myeloid leukemia cells
    Oshrat Hershkovitz Rokah
    Felsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 7:e35501. 2012
    ..Our objective is to decipher a miRNA expression signature associated with CML and to determine potential target genes and signaling pathways affected by these signature miRNAs...
  60. ncbi Role of miR-155 in breast cancer
    Jie Wang
    Department of Surgery, Hushan Hospital, Fudan University, Shanghai, China
    Front Biosci (Landmark Ed) 17:2350-5. 2012
    ..The microRNA (miRNA) encoded by mir-155 is known to be oncogenic in multiple tumors. This review summarizes the signaling pathways that are regulated by miR-155 in breast cancer and discusses therapeutic possibilities related to miR-155...
  61. pmc MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status
    Isabella Faraoni
    Laboratory of Neuro Oncohematology, Santa Lucia Foundation, Rome, Italy
    J Hematol Oncol 5:26. 2012
    ..Three types of normalization were used for the data validation...
  62. doi The oncogenic role of miR-155 in breast cancer
    Sam Mattiske
    Centre for Personalised Cancer Medicine, Cancer Therapeutics Laboratory, Department of Medicine, University of Adelaide, Australia
    Cancer Epidemiol Biomarkers Prev 21:1236-43. 2012
    ..This is the first review examining the role of miR-155 in breast cancer progression. The collated data of target genes and biologic pathways of miR-155 identified in this review suggest new avenues of research for this oncogenic miRNA...
  63. doi Mutant p53 drives invasion in breast tumors through up-regulation of miR-155
    P M Neilsen
    Centre for Personalised Cancer Medicine, University of Adelaide, Adelaide, SA, Australia
    Oncogene 32:2992-3000. 2013
    ..Collectively, these findings suggest that miR-155 targeted therapies may provide an attractive approach to treat mutant p53-expressing tumors...
  64. pmc MiR-155 induction by microbes/microbial ligands requires NF-κB-dependent de novo protein synthesis
    Thomas J Cremer
    Molecular, Cellular, and Developmental Biology Program, The Ohio State University Columbus, OH, USA
    Front Cell Infect Microbiol 2:73. 2012
    ..This study provides new insight into the complex regulation of miR-155 during microbial infection...
  65. pmc A role for microRNA-155 modulation in the anti-HIV-1 effects of Toll-like receptor 3 stimulation in macrophages
    Gokul Swaminathan
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    PLoS Pathog 8:e1002937. 2012
    ..Our findings provide evidence that miR-155 exerts an anti-HIV-1 effect by targeting several HIV-1 dependency factors involved in post-entry, pre-integration events, leading to severely diminished HIV-1 infection...
  66. doi Regulation of the MIR155 host gene in physiological and pathological processes
    Terry S Elton
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA College of Pharmacy, Division of Pharmacology, The Ohio State University, Columbus, OH, USA Department of Medicine, Division of Cardiology, The Ohio State University, Columbus, OH, USA Electronic address
    Gene 532:1-12. 2013
    ..miR-155-5p and miR-155-3p are processed from the B-cell Integration Cluster (BIC) gene (now designated, MIR155 host gene or MIR155HG)...
  67. doi 17β-estradiol up-regulates miR-155 expression and reduces TP53INP1 expression in MCF-7 breast cancer cells
    Chunmei Zhang
    Department of Pathophysiology, School of Basic Medicine, Chongqing Medical University, Chongqing, China
    Mol Cell Biochem 379:201-11. 2013
    ....
  68. pmc Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients
    Guido Marcucci
    The Ohio State University, Comprehensive Cancer Center, Biomedical Research Tower 460 W 12th Ave, Columbus, OH 43210, USA
    J Clin Oncol 31:2086-93. 2013
    ....
  69. pmc Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia
    Alessandra Ferrajoli
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
    Blood 122:1891-9. 2013
    ..Our findings support the use of cellular and plasma levels of miR-155 as biomarkers for the risk of progression in individuals with MBL, as well as to identify patients with CLL who may not respond well to therapy. ..
  70. pmc Identification of an NF-κB p50/p65-responsive site in the human MIR155HG promoter
    Ryan C Thompson
    Department of Biology, Boston University, Boston, MA 02215, USA
    BMC Mol Biol 14:24. 2013
    ..Nevertheless, direct regulation of the human MIR155HG promoter by NF-κB has not been convincingly demonstrated previously...
  71. pmc Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway
    Gang Wan
    School of Life Sciences Tsinghua University Beijing, China Key Lab in Healthy Science and Technology Division of Life Science Graduate School at Shenzhen Tsinghua University Shenzhen, China
    Autophagy 10:70-9. 2014
    ..Here, we describe hypoxia-induced MIR155 as a potent inducer of autophagy...
  72. pmc MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN)
    Rocio T Martinez-Nunez
    Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, and Southampton General Hospital, Southampton, UK
    J Biol Chem 284:16334-42. 2009
    ..Thus, our results suggest a mechanism by which miR-155 regulates proteins involved in the cellular immune response against pathogens that could have clinical implications in the way pathogens enter the human organism...
  73. doi MicroRNA-218 inhibits cell migration and invasion in renal cell carcinoma through targeting caveolin-2 involved in focal adhesion pathway
    Takeshi Yamasaki
    Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    J Urol 190:1059-68. 2013
    ..We investigated the functional significance of miR-218 in cancer cells and identified what are to our knowledge novel miR-218 mediated cancer pathways in renal cell carcinoma...
  74. doi Changes in microRNA expression in peripheral mononuclear cells according to the progression of osteoarthritis
    Atsushi Okuhara
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Mod Rheumatol 22:446-57. 2012
    ..This evidence could lead to the elucidation of the mechanism underlying OA pathogenesis and hence to a novel therapeutic strategy for OA...
  75. doi Increased miRNA-146a and miRNA-155 expressions in oral lichen planus
    Telma Cristina Arão
    Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Arch Dermatol Res 304:371-5. 2012
    ..Our results showed increased expression of miRNA-146a and miRNA-155 in OLP lesions. In conclusion, these data highlight the possibility of miRNA-146a and miRNA-155 involvement in the regulation of the immune response in OLP...
  76. doi MicroRNA expression profile helps to distinguish benign nodules from papillary thyroid carcinomas starting from cells of fine-needle aspiration
    Patrizia Agretti
    Department of Endocrinology, Research Center of Excellence AmbiSEN, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 167:393-400. 2012
    ..Fine-needle aspiration (FNA) with cytological evaluation is the most reliable tool for malignancy prediction in thyroid nodules, but cytological diagnosis remains undetermined for 20% of nodules...
  77. doi Silencing of miR155 promotes the production of inflammatory mediators in Guillain-Barré syndrome in vitro
    Yu Zhong Wang
    Department of Neurology, Affiliated Hospital of Jining Medical College, 79 Guhuai Road, Jining, 272029, Shandong Province, People s Republic of China
    Inflammation 36:337-45. 2013
    MicroRNA-155 (miR155) has been demonstrated as a central regulator of immune responses induced by inflammatory mediators. Previous studies suggest that miR155 may play adverse effects in various diseases...
  78. pmc A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo
    Christine Dahlke
    Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
    PLoS ONE 7:e49435. 2012
    ....
  79. pmc Enhanced susceptibility to Citrobacter rodentium infection in microRNA-155-deficient mice
    Simon Clare
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    Infect Immun 81:723-32. 2013
    ..A similarly susceptible phenotype was observed in μMT mice reconstituted with miR-155-deficient B cells, indicating that miR-155 is required intrinsically for mediating protection against this predominantly luminal bacterial pathogen...
  80. pmc Overexpression of miR -155 promotes proliferation and invasion of human laryngeal squamous cell carcinoma via targeting SOCS1 and STAT3
    Xu Dong Zhao
    Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, Shenyang, China
    PLoS ONE 8:e56395. 2013
    ..The current findings suggest that miR-155 play promotingrole during the development of LSCC, and miR-155 may be a useful marker for the prognosis and assessment of therapeutic effects...
  81. pmc MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer
    Jan C Dudda
    Ludwig Center for Cancer Research, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 38:742-53. 2013
    ..Similarly, Mir155(-/-) CD8(+) T cells were ineffective at controlling tumor growth, whereas miRNA-155 overexpression enhanced the ..
  82. doi Autoantibody induction by DNA-containing immune complexes requires HMGB1 with the TLR2/microRNA-155 pathway
    Zhenke Wen
    Institute for Immunobiology, Shanghai Medical College of Fudan University, Shanghai 200032, China
    J Immunol 190:5411-22. 2013
    ..These findings identify a novel mechanism to account for the persistent production of anti-dsDNA Ab in SLE and a clue for developing a novel therapeutic strategy against SLE...
  83. doi BIC is processed efficiently to microRNA-155 in Burkitt lymphoma cells
    T Zhang
    Leukemia 22:1795-7. 2008
  84. pmc MicroRNA expression profiles predictive of human renal allograft status
    Dany Anglicheau
    Division of Nephrology and Hypertension, Department of Medicine, New York Presbyterian Weill Cornell Medical Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:5330-5. 2009
    ..Our studies, in addition to suggesting a cellular basis for the altered intragraft expression of miRNAs, propose that miRNA expression patterns may serve as biomarkers of human renal allograft status...
  85. pmc Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenchymal interactions
    Nicolas Pottier
    CNRS, Institut de Pharmacologie Moleculaire et Cellulaire, UMR6097, Sophia Antipolis, France
    PLoS ONE 4:e6718. 2009
    ..In this study, we sought to identify the repertoire of microRNAs (miRNAs) in normal lung human fibroblasts and their potential regulation by the cytokines TNF-alpha, IL-1beta and TGF-beta...
  86. pmc miR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression
    Heiko F Stahl
    Boehringer Ingelheim Pharma GmbH and Co KG, Respiratory Diseases Research, Genomics Group, Biberach an der Riss, Germany
    PLoS ONE 4:e7158. 2009
    ..Recent work using Dicer-deficient mice irrevocably demonstrated the importance of miRNAs for nTreg cell-mediated tolerance...
  87. pmc MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response
    Thomas J Cremer
    Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 4:e8508. 2009
    ..However, impaired miR-155 induction by SCHU S4 may help explain the lack of both SHIP down-regulation and pro-inflammatory response and may account for the virulence of Type A Francisella...
  88. ncbi Expression of microRNA-155 precursor in peripheral blood mononuclear cells from Hepatitis C patients after antiviral treatment
    M Sidorkiewicz
    Department of Medical Biochemistry, Medical University of Lodz, ul Mazowiecka 6 8, Lodz, Poland
    Acta Virol 54:75-8. 2010
    ..Further, we found that 83% of PBMCs samples were BIC-positive in a group of patients that eliminated HCV RNA only from serum. The lowest expression of BIC was found in patients that eliminated HCV RNA from both serum and PBMCs...
  89. pmc Helicobacter pylori induces miR-155 in T cells in a cAMP-Foxp3-dependent manner
    Lina Fassi Fehri
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
    PLoS ONE 5:e9500. 2010
    ..Taken together, our study describes, in the context of an H. pylori infection, a direct link between Foxp3 and miR-155 in human T cells and highlights the significance of cAMP in this miR-155 induction cascade...
  90. pmc Modulation of mismatch repair and genomic stability by miR-155
    Nicola Valeri
    Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Medical Center, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 107:6982-7. 2010
    ..Finally, a number of MSI tumors with unknown cause of MMR inactivation displayed miR-155 overexpression. These data provide support for miR-155 modulation of MMR as a mechanism of cancer pathogenesis...
  91. ncbi Identification of a new microRNA expression profile as a potential cancer screening tool
    Wilson Roa
    Alberta Laboratory for Environmental Cancer Risk and Assessment, Alberta, Canada
    Clin Invest Med 33:E124. 2010
    ..This study investigated miRNA expression profiles of human cancer cells in order to develop a screening method for lung cancer...
  92. doi MicroRNA-155 contributes to preeclampsia by down-regulating CYR61
    Yanqing Zhang
    Drum Tower Clinical Medical College, Nanjing Medical University, and the Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing, China
    Am J Obstet Gynecol 202:466.e1-7. 2010
    ..The aim of this study was to characterize the molecular mechanism of preeclampsia (PE) development through miR-155...
  93. doi MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4
    Eniko Sonkoly
    Dermatology and Venereology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 126:581-9.e1-20. 2010
    ..MicroRNAs (miRNAs) are short noncoding RNAs that suppress gene expression at the posttranscriptional level. Atopic dermatitis is a common chronic inflammatory skin disease characterized by the presence of activated T cells within the skin...
  94. doi Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosus
    Gang Wang
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Rheumatol 37:2516-22. 2010
    ..Recent studies showed that micro-RNA play important roles in the pathogenesis of autoimmune diseases. We studied the levels of miR-146a and miR-155 in the serum and urinary supernatant of patients with systemic lupus erythematosus (SLE)...
  95. ncbi [Expression and its clinical significance of hsa-miR-155 in serum of endometrial cancer]
    Zhi Qin Tan
    Department of Obstetrics and Gynecology, The 169th Hospital of PLA, Hengyang of Hunan Province 421002, China
    Zhonghua Fu Chan Ke Za Zhi 45:772-4. 2010
    ..to investigate the expression of the hsa-miR-155 in serum of endometrial cancer and its clinical significance...
  96. doi Single point mutation of microRNA may cause butterfly effect on alteration of global gene expression
    Han Chia Lee
    Institute of Biotechnology in Medicine, Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, Taipei 11221, Taiwan, ROC
    Biochem Biophys Res Commun 404:1065-9. 2011
    ..Provided that over 800 miRNAs have been identified in humans to date, mutation of miRNA is expected to play a critical role in species evolution and individual diversity...
  97. pmc miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg
    Mayuko Yamamoto
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories Inc, Okayama, Japan
    PLoS ONE 6:e16841. 2011
    ..Further studies by gain- and loss-of-function experiments supported a role for miR-155 in the regulation of FOXO3a protein expression in conventional T and HOZOT cells...
  98. pmc Ectopic expression of microRNA-155 enhances innate antiviral immunity against HBV infection in human hepatoma cells
    Chenhe Su
    School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
    Virol J 8:354. 2011
    ..Thus, we assume miR-155 may affect the immune response during HBV infection in human hepatoma cells...
  99. pmc Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes
    Praveen Sethupathy
    Department of Genetics, School of Medicine, University of Pennsylvania, PA, USA, and University Hospitals of Geneva, Switzerland
    Am J Hum Genet 81:405-13. 2007
    ..Indeed, we have shown in fibroblasts from monozygotic twins discordant for trisomy 21 that levels of AGTR1 protein are lower in trisomy 21...
  100. pmc Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
    Kaleb M Pauley
    Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
    Arthritis Res Ther 10:R101. 2008
    ..In this study, the expression of selected microRNAs is examined in rheumatoid arthritis...
  101. pmc Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer
    Ying Xie
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
    Lung Cancer 67:170-6. 2010
    ..The aim of this study was to determine whether aberrant miRNA expression can be used as a marker in sputum specimen for the diagnosis of non-small cell lung cancer (NSCLC)...

Research Grants3

  1. P13K/AKT crosstalk with ER-signaling and cell survival
    Matthew Burow; Fiscal Year: 2008
    ..This cross-talk and the mechanisms identified will be used to establish the biological relevancy of the pathway in terms of cell survival and altered SERM activity. ..
  2. Transformation of Cells by the REL Oncogene
    Thomas Gilmore; Fiscal Year: 2009
    ....
  3. HUMAN ANGIOTENSIN II RECEPTOR GENE REGULATION
    Terry Elton; Fiscal Year: 2009
    ..The knowledge gained from the proposed study may lead to the development of novel therapeutics for disease states in which aberrant regulation of hAT1 R expression occurs. ..