MIR221

Summary

Gene Symbol: MIR221
Description: microRNA 221
Alias: MIRN221, miRNA221, mir-221
Species: human

Top Publications

  1. ncbi Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo
    Chunzhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, PR China
    Int J Oncol 34:1653-60. 2009
  2. ncbi A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias
    Sebastian Kreil
    Leuk Res 33:e168-9. 2009
  3. ncbi Oncogenic KRAS regulates miR-200c and miR-221/222 in a 3D-specific manner in colorectal cancer cells
    Toshiyuki Tsunoda
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Anticancer Res 31:2453-9. 2011
  4. pmc MicroRNAs 221/222 and genistein-mediated regulation of ARHI tumor suppressor gene in prostate cancer
    Yi Chen
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Cancer Prev Res (Phila) 4:76-86. 2011
  5. ncbi miR-221/222 promote malignant progression of glioma through activation of the Akt pathway
    Junxia Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, P R China
    Int J Oncol 36:913-20. 2010
  6. doi MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27
    Michela Frenquelli
    Department of Oncology, Unit and Laboratory of Lymphoid Malignancies, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    Blood 115:3949-59. 2010
  7. doi Increased expression of microRNA-221 inhibits PAK1 in endothelial progenitor cells and impairs its function via c-Raf/MEK/ERK pathway
    Xiaoping Zhang
    Department of Nuclear Medicine, Shanghai 10th People s Hospital, Tongji University School of Medicine, Shanghai 200072, PR China
    Biochem Biophys Res Commun 431:404-8. 2013
  8. pmc Increased miR-221 expression in hepatocellular carcinoma tissues and its role in enhancing cell growth and inhibiting apoptosis in vitro
    Minhua Rong
    Research Department, Affiliated Cancer Hospital, Guangxi Medical University, 71 Hedi Road, Nanning, Guangxi Zhuang Autonomous Region 530021, PR China
    BMC Cancer 13:21. 2013
  9. pmc Correlation between Slug transcription factor and miR-221 in MDA-MB-231 breast cancer cells
    Elisabetta Lambertini
    Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, 44121, Italy
    BMC Cancer 12:445. 2012
  10. pmc MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B, CDKNIC and overall survival
    Kaitlyn Wurz
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195 6460, USA
    Genes Chromosomes Cancer 49:577-84. 2010

Research Grants

  1. Gene Expression in Alzheimer's Disease
    Walter Lukiw; Fiscal Year: 2006
  2. Novel System to Study Telomere Dynamics in Hemotopoiesis
    Ruben Carrasco; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications96

  1. ncbi Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo
    Chunzhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, PR China
    Int J Oncol 34:1653-60. 2009
    ....
  2. ncbi A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias
    Sebastian Kreil
    Leuk Res 33:e168-9. 2009
  3. ncbi Oncogenic KRAS regulates miR-200c and miR-221/222 in a 3D-specific manner in colorectal cancer cells
    Toshiyuki Tsunoda
    Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Anticancer Res 31:2453-9. 2011
    ..Oncogenic KRAS plays several key roles in a three-dimensional (3D) colonic-crypt model. However, miRNA expression regulated by oncogenic KRAS in this model is still elusive...
  4. pmc MicroRNAs 221/222 and genistein-mediated regulation of ARHI tumor suppressor gene in prostate cancer
    Yi Chen
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, California 94121, USA
    Cancer Prev Res (Phila) 4:76-86. 2011
    ..prostate cancer cells have decreased level of ARHI which could be caused by direct targeting of 3'UTR of ARHI by miR221/222...
  5. ncbi miR-221/222 promote malignant progression of glioma through activation of the Akt pathway
    Junxia Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, P R China
    Int J Oncol 36:913-20. 2010
    ..Our results suggest that miR-221/222 co-enhance the glioma malignant phenotype via activation of the Akt pathway mediated by regulation of common gene expression...
  6. doi MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27
    Michela Frenquelli
    Department of Oncology, Unit and Laboratory of Lymphoid Malignancies, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    Blood 115:3949-59. 2010
    ..These data indicate that the miR-221/222 cluster modulates the expression of p27 protein in CLL cells and lead to suggest that miR-221/222 and p27 may represent a regulatory loop that helps maintaining CLL cells in a resting condition...
  7. doi Increased expression of microRNA-221 inhibits PAK1 in endothelial progenitor cells and impairs its function via c-Raf/MEK/ERK pathway
    Xiaoping Zhang
    Department of Nuclear Medicine, Shanghai 10th People s Hospital, Tongji University School of Medicine, Shanghai 200072, PR China
    Biochem Biophys Res Commun 431:404-8. 2013
    ..Overall, these findings demonstrate that miR-221 affects the MEK/ERK pathway by targeting PAK1 to inhibit the proliferation of EPCs...
  8. pmc Increased miR-221 expression in hepatocellular carcinoma tissues and its role in enhancing cell growth and inhibiting apoptosis in vitro
    Minhua Rong
    Research Department, Affiliated Cancer Hospital, Guangxi Medical University, 71 Hedi Road, Nanning, Guangxi Zhuang Autonomous Region 530021, PR China
    BMC Cancer 13:21. 2013
    ....
  9. pmc Correlation between Slug transcription factor and miR-221 in MDA-MB-231 breast cancer cells
    Elisabetta Lambertini
    Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, 44121, Italy
    BMC Cancer 12:445. 2012
    ..Breast cancer and its metastatic progression is mainly directed by epithelial to mesenchymal transition (EMT), a phenomenon supported by specific transcription factors and miRNAs...
  10. pmc MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B, CDKNIC and overall survival
    Kaitlyn Wurz
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195 6460, USA
    Genes Chromosomes Cancer 49:577-84. 2010
    ..01). In contrast, CDKN1B expression was not associated with miR-221 or miR-222 expression. Neither somatic mutations nor methylation of the studied region explained the alterations in miR-221 and miR-222 expression in most carcinomas...
  11. pmc Do microRNA 96, 145 and 221 expressions really aid in the prognosis of prostate carcinoma?
    Sung Gu Kang
    Department of Urology, Korea University College of Medicine, Seoul 136 705, Republic of Korea
    Asian J Androl 14:752-7. 2012
    ..To utilize miRNA as a diagnostic tool in clinical practice, more research is needed to understand miRNA mechanisms, identify miRNA targets, and further characterize miRNA function...
  12. doi miR-221/222 suppression protects against endoplasmic reticulum stress-induced apoptosis via p27(Kip1)- and MEK/ERK-mediated cell cycle regulation
    Rongyang Dai
    Department of Biochemistry of Luzhou Medical College, Luzhou 646000, Sichuan, China
    Biol Chem 391:791-801. 2010
    ..Our results suggest that suppression of miR-221/222 plays a crucial role in the protection against apoptosis induced by ER stress in HCC cells...
  13. pmc MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma
    Chun zhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
    Mol Cancer 9:229. 2010
    ..Recent studies have reported that miR-221/222 regulate cell growth and cell cycle progression by targeting p27 and p57. However the underlying mechanism involved in cell survival modulation of miR-221/222 remains elusive...
  14. doi Overexpression of miR-221 is associated with aggressive clinicopathologic characteristics and the BRAF mutation in papillary thyroid carcinomas
    Yi li Zhou
    Department of Oncology, The First Affiliated Hospital of Wenzhou Medical College, No 2 Fuxue Lane, Wenzhou, Zhejiang, China
    Med Oncol 29:3360-6. 2012
    ..MiR-221 may be of potential importance in determining the aggressive properties of PTCs including the BRAF mutation, and it may further refine the risk stratification by BRAF mutation in PTCs...
  15. doi Circulating miR-221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression
    Xing Xiang Pu
    Department of Medical Oncology, Cancer Center, Sun Yat Sen University, Guangzhou 510060, China
    J Gastroenterol Hepatol 25:1674-80. 2010
    ..The present study was to test the availability of direct amplification of miRNAs from plasma without RNA extraction, and to evaluate its clinical application value in CRC...
  16. doi Use of microRNA expression levels to predict outcomes in resected stage I non-small cell lung cancer
    Eric Duncavage
    Department of Pathology, University of Utah, Salt Lake City, Utah, USA
    J Thorac Oncol 5:1755-63. 2010
    ..Identifying patients at risk for relapse after surgical resection is one of the important challenges today. MicroRNAs (miRNAs) regulate hundreds of genes central to maintaining a cancer phenotype...
  17. ncbi PUMA is a novel target of miR-221/222 in human epithelial cancers
    Chunzhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, PR China
    Int J Oncol 37:1621-6. 2010
    ..Together, these findings suggest that PUMA is a direct target of miR-221/222 that functions as an endogenous apoptosis regulator in these epithelial cancers...
  18. pmc MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways
    X Rao
    Interdisciplinary Biochemistry Graduate Program, Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, USA
    Oncogene 30:1082-97. 2011
    ....
  19. doi Clinical significance of miR-221 and its inverse correlation with p27Kip¹ in hepatocellular carcinoma
    Xinhui Fu
    Laboratory of Surgery, The First Affiliated Hospital, Sun Yat Sen Zhongshan University, Guangzhou, 510080 Guangdong, People s Republic of China
    Mol Biol Rep 38:3029-35. 2011
    ..In conclusion, miR-221 is important in tumorigenesis of HCC, possibly by specifically down-regulating p27(Kip1), a cell-cycle inhibitor. These results indicate miR-221 as a new therapeutic target in HCC...
  20. pmc High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma
    Chunzhi Zhang
    Department of Radiation Oncology, Tianjin Huanhu Hospital, Tianjin 300060, China
    J Transl Med 10:119. 2012
    ..MiR-221 and miR-222 (miR-221/222), upregulated in gliomas, can regulate glioma cell cycle progression and apoptosis, respectively. However, the association of miR-221/222 with glioma cell invasion and survival remains unknown...
  21. ncbi Increased Expression of MicroRNA-221 in gastric cancer and its clinical significance
    K Liu
    Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
    J Int Med Res 40:467-74. 2012
    ..This study aimed to characterize the role of miR-221 in the initiation and malignant progression of gastric cancer...
  22. pmc MicroRNA expression aids the preoperative diagnosis of pancreatic ductal adenocarcinoma
    Nicole C Panarelli
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Pancreas 41:685-90. 2012
    ....
  23. doi miR-221/222 is the regulator of Cx43 expression in human glioblastoma cells
    Jianwei Hao
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, PR China
    Oncol Rep 27:1504-10. 2012
    ..We conclude that miR-221/222 function as oncogenic microRNAs in human gliomas, at least in part, by targeting Cx43...
  24. ncbi MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis
    Tomohiro Ogawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno, Osaka, Japan
    Gut 61:1600-9. 2012
    ..MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer...
  25. pmc MicroRNA-221 inhibits CDKN1C/p57 expression in human colorectal carcinoma
    Kai Sun
    Department of General Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, China
    Acta Pharmacol Sin 32:375-84. 2011
    ..To investigate the regulatory effect of microRNA-221 (miR-221) on CDKN1C/p57 expression in colorectal carcinoma (CRC)...
  26. doi Plasma miR-221 as a predictive biomarker for chemoresistance in breast cancer patients who previously received neoadjuvant chemotherapy
    Ruihua Zhao
    Department of Breast Surgery, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    Onkologie 34:675-80. 2011
    ..This study aimed to explore the potential role of miR-221 as a biomarker for chemosensitivity in breast cancer patients who previously received NAC...
  27. doi Deregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma
    Sun Och Yoon
    Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    Hum Pathol 42:1391-400. 2011
    ....
  28. doi MiR-221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2
    Chang Zheng
    Department of Urology, General Hospital of Jinan Military Command, 25 Shifan Road, 250031 Jinan, China
    Med Oncol 29:815-22. 2012
    ..We also suggest that miR-221 may control the migration of AIPC cells through DVL2, working as a key regulator in advanced CaP. The role of miR-221 in other target mRNA needs to be further investigated...
  29. pmc miR-221 silencing blocks hepatocellular carcinoma and promotes survival
    Jong Kook Park
    College of Pharmacy, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 71:7608-16. 2011
    ..Taken together, our findings offer a preclinical proof of efficacy for chol-anti-miR-221 in a valid orthotopic mouse model of HCC, suggesting that this targeted agent could benefit treatment for patients with advanced HCC...
  30. doi miR-221/222 targeting of trichorhinophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer
    Susanna Stinson
    Department of Molecular Diagnostics and Cancer Cell Biology, Genentech, Inc, South San Francisco, CA, USA
    Sci Signal 4:pt5. 2011
    ..TRPS1 inhibited EMT by directly repressing expression of ZEB2 (Zinc finger E-box-binding homeobox 2). Therefore, miR-221/222 may contribute to the aggressive clinical behavior of basal-like breast cancers...
  31. pmc miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPμ
    C Quintavalle
    Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Naples, Italy
    Oncogene 31:858-68. 2012
    ..In conclusion, our results suggest that miR-221 and -222 regulate glioma tumorigenesis at least in part through the control of PTPμ protein expression...
  32. doi TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer
    Susanna Stinson
    Department of Molecular Diagnostics and Cancer Cell Biology, Genentech Inc, South San Francisco, CA 94080, USA
    Sci Signal 4:ra41. 2011
    ..We conclude that by promoting EMT, miR-221/222 may contribute to the more aggressive clinical behavior of basal-like breast cancers...
  33. pmc miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222
    M Acunzo
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Oncogene 31:634-42. 2012
    ..Moreover, we found that miR-130a reduced migratory capacity of NSCLC. A better understanding of MET-miR-221 and 222 axis regulation in drug resistance is the key in developing new strategies in NSCLC therapy...
  34. pmc MicroRNA-221 regulates high glucose-induced endothelial dysfunction
    Yangxin Li
    Texas Heart Institute and The University of Texas Medical School, Heart Failure and Stem Cell, P O Box 20345, MC 2 255, 6770 Bertner Avenue, Houston, TX 77030, USA
    Biochem Biophys Res Commun 381:81-3. 2009
    ..These findings suggest that manipulation of the miR-221-c-kit pathway may offer a novel strategy for treatment of vascular dysfunction in diabetic patients...
  35. pmc The role of microRNA genes in papillary thyroid carcinoma
    Huiling He
    Human Cancer Genetics Program, Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 102:19075-80. 2005
    ..We conclude that up-regulation of several miRs and regulation of KIT are involved in PTC pathogenesis, and that sequence changes in genes targeted by miRNAs can contribute to their regulation...
  36. ncbi miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1
    Silvia Galardi
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier, 1 00133 Rome, Italy
    J Biol Chem 282:23716-24. 2007
    ....
  37. ncbi Regulation of p27Kip1 by miRNA 221/222 in glioblastoma
    Jana K Gillies
    Ottawa Health Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada
    Cell Cycle 6:2005-9. 2007
    ..These data show that p27(Kip1) is a direct target for microRNAs 221 and 222, and suggest a role for these microRNAs in promoting the aggressive growth of human glioblastoma...
  38. ncbi MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle
    Rosa Visone
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Via Pansini, 5, 80131 Naples, Italy
    Endocr Relat Cancer 14:791-8. 2007
    ..Therefore, the data reported here demonstrate that miR-221 and miR-222 are endogenous regulators of p27(Kip1) protein expression, and thereby, the cell cycle...
  39. pmc MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation
    Nadia Felli
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Proc Natl Acad Sci U S A 102:18081-6. 2005
    ..In erythropoietic (E) culture of cord blood CD34+ progenitor cells, the level of miR 221 and 222 is gradually and sharply down-modulated...
  40. doi MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
    F Fornari
    1Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Policlinico S Orsola, Bologna, Italy
    Oncogene 27:5651-61. 2008
    ..These findings establish a basis toward the development of therapeutic strategies aimed at blocking miR-221 in HCC...
  41. pmc MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1
    Tyler E Miller
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:29897-903. 2008
    ..This finding also provides the rationale for the application of altered expression of specific miRNAs as a predictive tamoxifen-resistant breast cancer marker...
  42. pmc MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer
    Jian Jun Zhao
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 283:31079-86. 2008
    ....
  43. pmc Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype
    Brandi N Davis
    Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Biol Chem 284:3728-38. 2009
    ..Our study demonstrates that PDGF signaling, by modulating the expression of miR-221, regulates two critical determinants of the vSMC phenotype; they are SMC gene expression and cell proliferation...
  44. doi MicroRNA-dependent regulation of cKit in cutaneous melanoma
    O Igoucheva
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    Biochem Biophys Res Commun 379:790-4. 2009
    ..They also suggest that regulation of expression and functional activity of identified up-regulated miRNAs should be further studied in the context of malignant melanoma...
  45. pmc The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines
    Tong Sun
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 69:3356-63. 2009
    ..In conclusion, our data suggest the involvement of miR-221 and miR-222 in the development or maintenance of the CRPC phenotype...
  46. doi Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma
    Jong Kook Park
    Ohio State University, Columbus, 43210, USA
    Pancreas 38:e190-9. 2009
    ..The contribution of overexpressed microRNA-21 and -221 (miR-21 and miR-221) to the malignant phenotype was determined by inhibiting these miRNAs using antisense oligonucleotides...
  47. pmc miR-21, miR-221 and miR-222 expression and prostate cancer recurrence among obese and non-obese cases
    Ernest K Amankwah
    Department of Cancer Epidemiology, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
    Asian J Androl 15:226-30. 2013
    ..Future larger studies are warranted to confirm these initial findings and to elucidate the mechanisms involved...
  48. pmc miR-221 overexpression contributes to liver tumorigenesis
    Pascal Pineau
    Nuclear Organization and Oncogenesis Unit, Institut National de Santé et de Recherche Médicale U579, Institut Pasteur, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 107:264-9. 2010
    ..Thus, the use of synthetic inhibitors of miR-221 may prove to be a promising approach to liver cancer treatment...
  49. doi Prognostic significance of serum microRNA-221 expression in human epithelial ovarian cancer
    Fanzhen Hong
    Department of Obstetrics and Gynaecology, Second Hospital of Shandong University, Jinan, China
    J Int Med Res 41:64-71. 2013
    ..To evaluate the feasibility of using serum microRNA (miR)-221 as a noninvasive diagnostic and prognostic biomarker in epithelial ovarian cancer (EOC)...
  50. pmc miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation
    Michela Garofalo
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 16:498-509. 2009
    ..Finally, we demonstrate that the MET oncogene is involved in miR-221&222 activation through the c-Jun transcription factor...
  51. pmc miR-221 promotes tumorigenesis in human triple negative breast cancer cells
    Rounak Nassirpour
    Oncology Research, Pfizer Worldwide Research and Development, San Diego, California, United States of America
    PLoS ONE 8:e62170. 2013
    ..Therefore, miR-221 functions as an oncogene and is essential in regulating tumorigenesis in TNBCs both in vitro as well as in vivo...
  52. doi MicroRNA-221 silencing predisposed human bladder cancer cells to undergo apoptosis induced by TRAIL
    Qiang Lu
    Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Urol Oncol 28:635-41. 2010
    ..To explore novel and effective therapies against bladder cancer, we explored the effects of miRNA-221 silencing on the survival of bladder cancer cells...
  53. pmc MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A
    T Sun
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Oncogene 33:2790-800. 2014
    ..We hypothesize that a major biological consequence of upregulation of miR-221 is reprogramming of AR signaling, which in turn may mediate the transition to the CRPC phenotype. ..
  54. pmc MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality
    Laura Gramantieri
    Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
    Clin Cancer Res 15:5073-81. 2009
    ..Deregulated cell proliferation and apoptosis play a major role in hepatocellular carcinoma (HCC). MicroRNAs participate in the modulation of key molecules linked to hepatocarcinogenesis...
  55. pmc miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer
    Michael S Hwang
    Department of Molecular Diagnostics and Cancer Cell Biology, Genentech, Inc, South San Francisco, California, United States of America
    PLoS ONE 8:e66502. 2013
    ..These results suggest that ADIPOR1 may play an important role in breast cancer progression and metastasis, and could potentially offer an alternative therapeutic strategy for basal-like breast cancer patients...
  56. doi Expression of microRNA-221 is progressively reduced in aggressive prostate cancer and metastasis and predicts clinical recurrence
    Martin Spahn
    Department of Urology and Paediatric Urology, University of Wurzburg, Wurzburg, Germany
    Int J Cancer 127:394-403. 2010
    ..Our results showed that progressive miR-221 downregulation hallmarks metastasis and presents a novel prognostic marker in high risk PCa. This suggests that miR-221 has potential as a diagnostic marker and therapeutic target in PCa...
  57. pmc The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice
    Neri Mercatelli
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 3:e4029. 2008
    ..We previously showed this regulatory relationship in prostate carcinoma cell lines in vitro, underlying the role of miR-221/222 as inducers of proliferation and tumorigenicity...
  58. ncbi miR-221/222 confers radioresistance in glioblastoma cells through activating Akt independent of PTEN status
    W Li
    Department of Radiation Oncology, Tianjin Huanhu Hospital, Tianjin 300060, China
    Curr Mol Med 14:185-95. 2014
    ....
  59. doi MicroRNA-221/222 regulate ox-LDL-induced endothelial apoptosis via Ets-1/p21 inhibition
    Bing Qin
    Department of Neurology, The Third Affiliated Hospital of Sun Yat Sen University, NO 600 TianHe Road, Guangzhou, 510630, Guangdong, People s Republic of China
    Mol Cell Biochem 405:115-24. 2015
    ..These findings suggest that manipulation of the miR-221/222-Ets-1-p21 pathway may offer a novel strategy for treatment of endothelial apoptosis and atherosclerosis. ..
  60. doi Expression patterns of miR-221 and its target Caspase-3 in different cancer cell lines
    Sercan Ergun
    Department of Medical Biology, Faculty of Medicine, Gaziantep University, Sehitkamil, 27310, Gaziantep, Turkey
    Mol Biol Rep 41:5877-81. 2014
    ..We expect that our study might pave the way for better understanding the role of miR-221 in apoptotic regulation of caspase-3. ..
  61. pmc Anti-miRNA-221 sensitizes human colorectal carcinoma cells to radiation by upregulating PTEN
    Qi Xue
    Qi Xue, Kai Sun, Hai Jun Deng, Shang Tong Lei, Jing Qing Dong, Guo Xin Li, Department of General Surgery, Nanfang Hospital of Southern Medical University, Guangzhou 510515, Guangdong Province, China
    World J Gastroenterol 19:9307-17. 2013
    ..To investigate the regulative effect of miRNA (miR)-221 on colorectal carcinoma (CRC) cell radiosensitivity and the underlying mechanisms...
  62. pmc Influenza A Virus-Induced Expression of a GalNAc Transferase, GALNT3, via MicroRNAs Is Required for Enhanced Viral Replication
    Shoko Nakamura
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto, Japan Department of Tumor Viruses, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Virol 90:1788-801. 2015
    ..Our results demonstrate not only the molecular mechanism underlying rapid mucin production during IAV infection but also the contribution of O-linked glycosylation to the replication and propagation of IAV in lung cells...
  63. pmc Overexpression of primary microRNA 221/222 in acute myeloid leukemia
    Anna Rommer
    Department of Medicine I, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    BMC Cancer 13:364. 2013
    ..In this context, leukemia-associated misexpression of microRNAs (miRNAs) has been studied, but no coherent picture has emerged yet, thus warranting further investigations...
  64. doi Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222
    Magne Skårn
    Department of Tumor Biology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    Stem Cells Dev 21:873-83. 2012
    ....
  65. pmc Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis
    N S Lai
    Division of Allergy, Immunology and Rheumatology, Buddhist Dalin Tzu Chi General Hospital, Taiwan
    Clin Exp Immunol 173:47-57. 2013
    ..In the functional studies, the increased let-7i expression facilitated the T helper type 1 (IFN-γ) immune response in T cells...
  66. ncbi miRNA expression profiles of oral squamous cell carcinomas
    Katalin Gombos
    Institute of Public Health, Faculty of Medicine, Clinic Center University of Pécs, Pecs, Hungary
    Anticancer Res 33:1511-7. 2013
    ..We aimed to analyze the expression patterns of a set of miRNAs in human TNM stage I and II OSCC samples in an autologous normal mucosa-controlled experimental design...
  67. pmc The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR-221&222-c-FOS pathway
    M Cristina Errico
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Int J Cancer 133:879-92. 2013
    ....
  68. doi HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells
    Stefania Mardente
    Department of Experimental Medicine, Sapienza University of Rome, I 00161 Rome, Italy
    Oncol Rep 28:2285-9. 2012
    ..The overexpression of oncogenic miR-221 and miR-222 caused by HMGB1 is associated with an increase in malignancy scores, namely cell growth and motility...
  69. doi MicroRNA expression profile helps to distinguish benign nodules from papillary thyroid carcinomas starting from cells of fine-needle aspiration
    Patrizia Agretti
    Department of Endocrinology, Research Center of Excellence AmbiSEN, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 167:393-400. 2012
    ..Fine-needle aspiration (FNA) with cytological evaluation is the most reliable tool for malignancy prediction in thyroid nodules, but cytological diagnosis remains undetermined for 20% of nodules...
  70. doi Urinary sediment ICAM-1 level in lupus nephritis
    J Guan
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Lupus 21:1190-5. 2012
    ....
  71. doi Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model
    Ioannis Pandis
    Biomedical Sciences Research Centre Alexander Fleming, Institute of Immunology, Vari 16672, Greece
    Ann Rheum Dis 71:1716-23. 2012
    ..To identify novel microRNA (miR) associations in synovial fibroblasts (SF), by performing miR expression profiling on cells isolated from the human tumour necrosis factor (TNF) transgenic mouse model (TghuTNF, Tg197) and patients biopsies...
  72. ncbi The expression and clinical significance of GTP-binding RAS-like 3 (ARHI) and microRNA 221 and 222 in prostate cancer
    D Lin
    Urology Department, The First Affiliated Hospital of Suzhou University, Suzhou, China
    J Int Med Res 39:1870-5. 2011
    ..Whether ARHI and microRNA 221 and 222 could be considered as biomarkers for disease progression in prostate cancer requires further investigation...
  73. doi Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status
    Lingchao Chen
    Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, PR China
    Oncol Rep 27:854-60. 2012
    ..Taken together, our study indicates that downregulated miR-221/222 can sensitize glioma cells to TMZ by regulating apoptosis independently of p53 status...
  74. pmc MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-α during TLR4-induced gene reprogramming
    Mohamed El Gazzar
    Department of Internal Medicine, East Tennessee State University College of Medicine, Johnson City, TN 37614, USA
    J Leukoc Biol 90:509-19. 2011
    ..Our results also imply that therapies designed to reverse endotoxin tolerance as potential therapies for sepsis should be directed at the transcription and translation pathways of reprogramming...
  75. ncbi [MicroRNA-221 controls CDKN1C/P57 expression in human colorectal carcinoma]
    Kai Sun
    Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Zhonghua Wei Chang Wai Ke Za Zhi 14:279-83. 2011
    ..The effect of miR-221-specific inhibitor on cell proliferation and apoptosis in CRC cells was also assessed...
  76. pmc miR-221 suppresses ICAM-1 translation and regulates interferon-gamma-induced ICAM-1 expression in human cholangiocytes
    Guoku Hu
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska 68178, USA
    Am J Physiol Gastrointest Liver Physiol 298:G542-50. 2010
    ....
  77. pmc Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses
    Gerard J Nuovo
    Department of Pathology, The Ohio State University Medical Center, Room 081 Heart and Lung Research Institute, 473 W 12th Avenue, Columbus, OH 43210, USA
    Diagn Mol Pathol 17:145-50. 2008
    ..In conclusion, benign metastasizing leiomyomas are indeed most likely benign lesions, and up-regulation of miR-221 expression is an accurate way to differentiate leiomyosarcoma from benign metastasizing leiomyoma...
  78. doi Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM)
    W J Lukiw
    LSU Neuroscience Center of Excellence and LSU Department of Neurosurgery, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8A4, New Orleans, LA, 70112, USA
    J Neurooncol 91:27-32. 2009
    ....
  79. pmc MicroRNA-221-222 regulate the cell cycle in mast cells
    Ramon J Mayoral
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Immunol 182:433-45. 2009
    ..Our study provides further insights on miR-221-222 transcriptional regulation as well as evidences that miR-221-222 regulate cell cycle checkpoints in mast cells in response to acute activation stimuli...
  80. doi miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors
    Alfredo Conti
    Department of Neuroscience, A O U Policlinico Universitario, University of Messina, Italy
    J Neurooncol 93:325-32. 2009
    ....
  81. doi [The role of mir-221/222 in inhibiting endoplasmic reticulum stress-induced human hepatocarcinoma cell apoptosis]
    You ping Liu
    Department of Biochemistry, Luzhou Medical College, Luzhou Sichuan, China
    Zhonghua Gan Zang Bing Za Zhi 19:191-5. 2011
    ..To investigate the role of miR-221/222 in inhibiting endoplasmic reticulum stress-induced human hepatocarcinoma cells apoptosis...
  82. doi Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Leuk Res 34:328-34. 2010
    ..We conclude that inhibition of proliferation via over-expressed miR-150 might contribute to myelodysplastic haematopoiesis in MDS-del(5q)...
  83. pmc miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221
    Ai Kotani
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Blood 114:4169-78. 2009
    ..These results demonstrate that down-regulation of miR-128b and miR-221 is implicated in glucocorticoid resistance and that restoration of their levels is a potentially promising therapeutic in MLL-AF4 ALL...
  84. doi [Up-regulation of p27(kip1) by miR-221/222 antisense oligonucleotides enhances the radiosensitivity of U251 glioblastoma]
    Chunzhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital and Laboratory of Neuro Oncology, Tianjin Neurological Institute, Tianjin, 300052 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26:634-8. 2009
    ..To study the radiation-sensitizing effect of up-regulating p27(kip1) expression by knocking down miR-221/222 in the U251 human glioblastoma cell line...
  85. doi Upregulation of mir-221 and mir-222 in atypical teratoid/rhabdoid tumors: potential therapeutic targets
    Simone Treiger Sredni
    Cancer Biology and Epigenomics Program, Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Children s Memorial Hospital, 2300 Children s Plaza, Chicago, IL 60614, USA
    Childs Nerv Syst 26:279-83. 2010
    ..The aim of this study is to search for new therapeutic targets for atypical teratoid-rhabdoid tumors (ATRT)...
  86. pmc Thyroid hormone receptor beta (THRB) is a major target gene for microRNAs deregulated in papillary thyroid carcinoma (PTC)
    Krystian Jazdzewski
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, 804 Biomedical Research Tower, 460 West 12th Avenue, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 96:E546-53. 2011
    ..In mouse models, a truncated THRB gene leads to thyroid cancer. Previously, we observed up-regulation of the expression of eight microRNAs (miRs) in papillary thyroid carcinoma (PTC) tumors...
  87. pmc Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex
    Marco Gabbianelli
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, 00161 Rome, Italy
    Haematologica 95:1253-60. 2010
    ..MicroRNAs (miRs) play a pivotal role in normal hematopoiesis: downmodulation of miR-221/222 stimulates human erythropoietic proliferation through upmodulation of the kit receptor...
  88. doi MicroRNAs and potential target interactions in psoriasis
    John R Zibert
    Department of Dermato Allergology, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    J Dermatol Sci 58:177-85. 2010
    ..MicroRNAs are important in the pathogenesis of human diseases such as immunological disorders, as they regulate a broad range of biological processes...
  89. ncbi Global changes of mRNA expression reveals an increased activity of the interferon-induced signal transducer and activator of transcription (STAT) pathway by repression of miR-221/222 in glioblastoma U251 cells
    Chunzhi Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P R China
    Int J Oncol 36:1503-12. 2010
    ..These data indicate for the first time a mechanism involving STAT1/2 upregulation under the transcriptional control of INF-alpha signaling after knockdown of miR-221/222 cluster in U251 glioma cells...
  90. pmc Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells
    Swadesh K Das
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 107:11948-53. 2010
    ..Targeted overexpression of hPNPase(old-35) might provide an effective therapeutic strategy for miR-221-overexpressing and IFN-resistant tumors, such as melanoma...
  91. doi A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility
    Martijn Kedde
    Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Nat Cell Biol 12:1014-20. 2010
    ..We have therefore uncovered a novel RBP-induced structural switch modulating microRNA-mediated gene expression regulation...
  92. pmc miR-221 Is down-regulated in TMPRSS2:ERG fusion-positive prostate cancer
    Aida Gordanpour
    Department of Laboratory Medicine and Pathobiology, University of Toronto, and Sunnybrook Research Institute, Toronto, Canada
    Anticancer Res 31:403-10. 2011
    ..Herein we report that in a large and diverse cohort of prostate carcinoma samples, miR-221 is down-regulated in patients with tumours bearing TMPRSS2:ERG fusion transcripts, thus providing a link between miRNA and gene fusion expression...
  93. pmc Down-regulation of microRNAs 222/221 in acute myelogenous leukemia with deranged core-binding factor subunits
    Matteo Brioschi
    Dipartimento di Biologia e Genetica per le Scienze Mediche, Facolta di Medicina, Universita degli Studi di Milano, Milan, Italy
    Neoplasia 12:866-76. 2010
    ....
  94. pmc A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma
    S E Godshalk
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA
    Oncogene 30:1542-50. 2011
    ..This work identifies a novel genetic marker for increased heritable risk of melanoma...
  95. pmc MicroRNA-221 controls expression of intercellular adhesion molecule-1 in epithelial cells in response to Cryptosporidium parvum infection
    Ai Yu Gong
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, NE 68178, USA
    Int J Parasitol 41:397-403. 2011
    ..These results indicate that miR-221-mediated translational suppression controls ICAM-1 expression in epithelial cells in response to C. parvum infection...
  96. doi Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors
    Marita Koelz
    Clinical Institute of Pathology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Int J Oncol 38:503-11. 2011
    ..Although miR-221/222 expression does not have an impact on diagnostics, it could be considered as a tool for future therapeutic strategies for GISTs, especially for tumors with secondary resistance to tyrosine kinase inhibitors...

Research Grants2

  1. Gene Expression in Alzheimer's Disease
    Walter Lukiw; Fiscal Year: 2006
    ..abstract_text> ..
  2. Novel System to Study Telomere Dynamics in Hemotopoiesis
    Ruben Carrasco; Fiscal Year: 2005
    ..He also holds a Ph.D. in Biochemistry. The research will be carried out in a cancer/aging biology laboratory within the Dana-Farber Cancer Institute, an affiliate of the Harvard Medical School, under the mentorship of Dr. Ron DePinho. ..