MIR27A

Summary

Gene Symbol: MIR27A
Description: microRNA 27a
Alias: MIR27, MIRN27A
Species: human

Top Publications

  1. pmc MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells
    Takayoshi Shirasaki
    Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Virol 87:5270-86. 2013
  2. doi miR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition
    Ziping Zhang
    General Surgery, Central Hospital of Shanghai Minhang District, China
    Cancer Genet 204:486-91. 2011
  3. doi MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A
    Carmen Urbich
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Blood 119:1607-16. 2012
  4. pmc Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer
    Renata Hezova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech
    World J Gastroenterol 18:2827-31. 2012
  5. doi A predicted miR-27a-mediated network identifies a signature of glioma
    Shuxu Yang
    Department of Neurosurgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou 310016, PR China
    Oncol Rep 28:1249-56. 2012
  6. doi TGF-β-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7
    S Min
    Department of Immunology, Nankai University School of Medicine, Tianjin, China
    Genes Immun 13:621-31. 2012
  7. pmc A genetic variant in pre-miR-27a is associated with a reduced renal cell cancer risk in a Chinese population
    Danni Shi
    State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China
    PLoS ONE 7:e46566. 2012
  8. pmc MiR-27a functions as a tumor suppressor in acute leukemia by regulating 14-3-3θ
    Kara A Scheibner
    Center for Stem Cell Biology and Regenerative Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 7:e50895. 2012
  9. pmc MiR-27 as a prognostic marker for breast cancer progression and patient survival
    Wei Tang
    Department of Breast Surgery, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    PLoS ONE 7:e51702. 2012
  10. doi Genetic variations in miR-27a gene decrease mature miR-27a level and reduce gastric cancer susceptibility
    Q Yang
    Institute for Chemical Carcinogenesis, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, People s Republic of China
    Oncogene 33:193-202. 2014

Research Grants

Scientific Experts

Detail Information

Publications73

  1. pmc MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells
    Takayoshi Shirasaki
    Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Virol 87:5270-86. 2013
    ..Thus, this negative feedback mechanism might contribute to the maintenance of a low viral load and would be beneficial to the virus by allowing it to escape host immune surveillance and establish a persistent chronic HCV infection...
  2. doi miR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition
    Ziping Zhang
    General Surgery, Central Hospital of Shanghai Minhang District, China
    Cancer Genet 204:486-91. 2011
    ..These results suggest an important role of miR-27 in regulating metastasis of gastric cancer and implicate the potential application of miR-27 in gastric cancer therapy...
  3. doi MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A
    Carmen Urbich
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Blood 119:1607-16. 2012
    ..In summary, we show that miR-27a/b promotes angiogenesis by targeting the angiogenesis inhibitor SEMA6A, which controls repulsion of neighboring endothelial cells...
  4. pmc Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer
    Renata Hezova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech
    World J Gastroenterol 18:2827-31. 2012
    ..To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-196a2, miR-27a and miR-146a genes are associated with sporadic colorectal cancer (CRC)...
  5. doi A predicted miR-27a-mediated network identifies a signature of glioma
    Shuxu Yang
    Department of Neurosurgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou 310016, PR China
    Oncol Rep 28:1249-56. 2012
    ..Our data may provide researchers with a better understanding of the mechanisms of the miR-27a-target network in glioma initiation and progression...
  6. doi TGF-β-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7
    S Min
    Department of Immunology, Nankai University School of Medicine, Tianjin, China
    Genes Immun 13:621-31. 2012
    ..The repeated infusion of miR-27a-engineered DCs into tumor tissues accelerated tumor growth, indicating that miR-27a is a potential target for tumor immunotherapy...
  7. pmc A genetic variant in pre-miR-27a is associated with a reduced renal cell cancer risk in a Chinese population
    Danni Shi
    State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China
    PLoS ONE 7:e46566. 2012
    ..The single nucleotide polymorphism (SNP) rs895819 is located at the terminal loop of pre-miR-27a. Here, we aimed to investigate whether SNP rs895819 was associated with the development of renal cell cancer (RCC) in a Chinese population...
  8. pmc MiR-27a functions as a tumor suppressor in acute leukemia by regulating 14-3-3θ
    Kara A Scheibner
    Center for Stem Cell Biology and Regenerative Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 7:e50895. 2012
    ..These data indicate that miR-27a contributes a tumor suppressor-like activity in acute leukemia cells via regulation of apoptosis, and that miR-27a and 14-3-3θ may be potential therapeutic targets...
  9. pmc MiR-27 as a prognostic marker for breast cancer progression and patient survival
    Wei Tang
    Department of Breast Surgery, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    PLoS ONE 7:e51702. 2012
    ..MicroRNA-27a (miR-27a) is thought to be an onco-microRNA that promotes tumor growth and metastasis by downregulating ZBTB10. The potential predictive value of miR-27a was studied in breast cancer patients...
  10. doi Genetic variations in miR-27a gene decrease mature miR-27a level and reduce gastric cancer susceptibility
    Q Yang
    Institute for Chemical Carcinogenesis, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, People s Republic of China
    Oncogene 33:193-202. 2014
    ..These results could be useful to assess individual susceptibility of gastric cancer and will improve our understanding of the potential contribution of miRNA SNPs to cancer pathogenesis. ..
  11. doi Pre-mir-27a rs895819 polymorphism and cancer risk: a meta-analysis
    Shanliang Zhong
    Center of Clinical Laboratory Science, Jiangsu Cancer Hospital, the Fourth Affiliated Hospital of Nanjing Medical University, Baiziting 42, Nanjing 210009, China
    Mol Biol Rep 40:3181-6. 2013
    ..7 %; GG+AG vs AA: OR = 0.85, 95 % CI = 0.76 ~ 0.94, P heterogeneity = 0.48, I (2) = 0). The findings suggest that pre-mir-27a rs895819 polymorphism may have some relation to breast cancer susceptibility or cancer development in Caucasian...
  12. ncbi Oncogenic MicroRNA-27a is a target for genistein in ovarian cancer cells
    Linlin Xu
    Department of Pharmacology, Nanjing Medical University, Jiangsu, China
    Anticancer Agents Med Chem 13:1126-32. 2013
    ....
  13. pmc Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells
    Hua Zhu
    Department of Pharmacology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, United States
    Biochem Pharmacol 76:582-8. 2008
    ....
  14. ncbi Association between the hsa-mir-27a variant and breast cancer risk: a meta-analysis
    Bin Wang
    Department of Oncology, Changhai Hospital, The Second Military Medical University, Shanghai, China
    Asian Pac J Cancer Prev 13:6207-10. 2012
    ..To derive a more precise effect on the association between SNP hsa-mir-27a rs895819 and breast cancer risk, we conducted a meta-analysis for the first time...
  15. pmc Primary microcephaly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma
    Thejaswini Venkatesh
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, Karnataka, India
    PLoS ONE 8:e54643. 2013
    ..Our study indicates for the first time that, in addition to its role in brain development, MCPH1 also functions as a tumor suppressor gene and is regulated by miR-27a...
  16. pmc Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2
    Mario Acunzo
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 110:8573-8. 2013
    ..In addition, we identify both direct and indirect mechanisms by which miR-27a can regulate both MET and EGFR. Thus, we propose a mechanism for MET and EGFR axis regulation that may lead to the development of therapeutics in lung cancer...
  17. doi miR-27a regulates endothelial differentiation of breast cancer stem like cells
    W Tang
    Breast Tumor Center, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    Oncogene 33:2629-38. 2014
    ..Thus, miR-27a promotes angiogenesis by mediating endothelial differentiation of BCSLCs and it may be a new target for anti-angiogenesis cancer therapy. ..
  18. pmc Coordinated targeting of the EGFR signaling axis by microRNA-27a*
    Xiaoli Wu
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Oncotarget 4:1388-98. 2013
    ..These findings identify miR-27a* as a functional star sequence that exhibits novel coordinated regulation of the EGFR pathway in solid tumors and potentially represents a novel therapeutic option. ..
  19. pmc MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K
    Gang Liu
    Department of Orthopaedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, P R China
    PLoS ONE 8:e75251. 2013
    ..This present study revealed that downregulated miR-27a might develop a novel intervention for IDD treatment through the prevention of apoptosis in Nucleus pulposus Cells. ..
  20. doi miRNA27a is a biomarker for predicting chemosensitivity and prognosis in metastatic or recurrent gastric cancer
    Dingzhi Huang
    Department of Gastrointestinal Medical Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Huanhuxi Rd, Tiyuanbei, Hexi District, Tianjin, 300060, P R China
    J Cell Biochem 115:549-56. 2014
    ..024). In patients with MRGC, miRNA27a is a potential biomarker for predicting resistance to fluoropyrimidine-based chemotherapy and a novel prognostic marker for gastric cancer...
  21. pmc MicroRNA-27 (miR-27) targets prohibitin and impairs adipocyte differentiation and mitochondrial function in human adipose-derived stem cells
    Ting Kang
    From the Cardiovascular Research Institute
    J Biol Chem 288:34394-402. 2013
    ..Our data suggest that miR-27 is an anti-adipogenic microRNA partly by targeting PHB and impairing mitochondrial function. Pharmacological modulation of miR-27 function may provide a new therapeutic strategy for the treatment of obesity. ..
  22. doi microRNA-27a functions as a tumor suppressor in esophageal squamous cell carcinoma by targeting KRAS
    Linan Zhu
    Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P R China
    Oncol Rep 31:280-6. 2014
    ..miR-27a exerts its tumor suppressor function through inhibition of the KRAS-related ERK pathways. Our findings suggest, for the first time, that miR-27a suppresses tumorigenesis of ESCC by targeting KRAS...
  23. doi Role of microRNA-27a in down-regulation of angiogenic factor AGGF1 under hypoxia associated with high-grade bladder urothelial carcinoma
    Yan Xu
    The Key Laboratory of Molecular Biophysics of the Ministry of Education, Department of Genetics and Developmental Biology, College of Life Science and Technology, Center for Human Genome Research, Cardio X Institute, Huazhong University of Science and Technology, Wuhan, PR China
    Biochim Biophys Acta 1842:712-25. 2014
    ....
  24. ncbi [Expression of microRNA 27a and its correlation with drug resistance in human ovarian cancer A2780/Taxol cells]
    Zhi Min Li
    Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Fu Chan Ke Za Zhi 45:372-5. 2010
    ..To investigate the expression of microRNA 27a (miR-27a) and relationship with drug resistance in human ovarian cancer A2780/Taxol cells...
  25. doi A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk
    Rongxi Yang
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Breast Cancer Res Treat 121:693-702. 2010
    ..We hypothesize that the G-variant of rs895819 might impair the maturation of the oncogenic miR-27a and thus, is associated with familial breast cancer risk...
  26. pmc Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes
    Ginette Tardif
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, Montreal, Quebec H2L 4M1, Canada
    BMC Musculoskelet Disord 10:148. 2009
    ..MMP-13 and IGFBP-5 are important factors involved in osteoarthritis (OA). We investigated whether two highly predicted microRNAs (miRNAs), miR-140 and miR-27a, regulate these two genes in human OA chondrocytes...
  27. doi Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women
    Tair Kontorovich
    Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Int J Cancer 127:589-97. 2010
    ..This study provides preliminary evidence for another regulatory level of penetrance of deleterious mutations in cancer predisposition genes...
  28. pmc Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells
    Irene K Guttilla
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 284:23204-16. 2009
    ..We have identified a novel mechanism of FOXO1 regulation, and targeting of FOXO1 by microRNAs may contribute to transformation or maintenance of an oncogenic state in breast cancer cells...
  29. pmc Upregulation of miR-23a-27a-24-2 cluster induces caspase-dependent and -independent apoptosis in human embryonic kidney cells
    Ravindresh Chhabra
    Institute of Genomics and Integrative Biology, Delhi, India
    PLoS ONE 4:e5848. 2009
    ....
  30. pmc A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis
    Oren Ben-Ami
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Proc Natl Acad Sci U S A 106:238-43. 2009
    ....
  31. doi MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin
    Tao Liu
    Tianjin Life Science Research Center, Tianjin Medical University, No 22, Qi Xiang Tai Road, Tianjin 300070, PR China
    Cancer Lett 273:233-42. 2009
    ..Down-regulation of prohibitin by miR-27a may explain why suppression of miR-27a can inhibit gastric cancer cell growth, further supporting that miR-27a functions as an oncogene...
  32. doi Down-regulation of miR-27a might reverse multidrug resistance of esophageal squamous cell carcinoma
    Hongwei Zhang
    Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032, Xi an, Shaanxi Province, China
    Dig Dis Sci 55:2545-51. 2010
    ..So far, the miRNAs involved in multidrug resistance of esophageal cancer have not been reported...
  33. pmc MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells
    Xiangrong Li
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, Texas 77843 4466, USA
    Endocrinology 151:2462-73. 2010
    ..Thus, miR-27a indirectly regulates E2-responsiveness in MCF-7 cells through suppression of ZBTB10, thereby enhancing expression of ERalpha...
  34. ncbi A polymorphism of microRNA 27a genome region is associated with the development of gastric mucosal atrophy in Japanese male subjects
    Tomiyasu Arisawa
    Department of Gastroenterology, Fujita Health University, School of Medicine, 1 98, Dengakugakubo, Toyoake, Japan
    Dig Dis Sci 52:1691-7. 2007
    ..The miR-27a genome region polymorphism may be an important definitive factor to develop the gastric mucosal atrophy in Japanese male subjects...
  35. doi MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells
    Zhimin Li
    Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
    Gynecol Oncol 119:125-30. 2010
    ..In this study, we investigated the role of miR-27a in the development of drug resistance in ovarian cancer cells...
  36. doi miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2
    Yihui Ma
    Department of Pathology, Peking Union Medical College Hospital, People s Republic of China
    Cancer Lett 298:150-8. 2010
    ..This suggests the potential for miR-27a to be used as a target in the diagnosis and treatment of pancreatic adenocarcinoma...
  37. doi Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression
    Qingmin Sun
    Department of Pharmacy, the Affiliated Wuxi Hospital for Maternal and Child Health Care of Nanjing Medical University, Wuxi, Jiangsu Province, China
    Cancer Sci 101:2241-7. 2010
    ..In conclusion, we were the first to show that a common polymorphism (rs895819) in hsa-mir-27a, by modulating miR-27a and ZBTB10 levels, acted as an important factor of the gastric cancer susceptibility...
  38. doi Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen
    Q Wang
    Department of Toxicology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat Sen University, Guangzhou, China
    Oncogene 30:3875-86. 2011
    ..These observations demonstrate that miR-27a functions as an oncogene in human tumorigenesis...
  39. ncbi MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression
    Mikael Lerner
    Department of Oncology Pathology Cancer Center Karolinska CCK, Karolinska Institutet, Stockholm, Sweden
    Cell Cycle 10:2172-83. 2011
    ..These data provide evidence for microRNA-mediated regulation of FBW7, and highlight the role of miR-27a as a novel factor fine-tuning the periodic events regulating cell cycle progression...
  40. pmc Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity
    Tae Don Kim
    Cell Therapy Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak ro, Yuseong, Daejeon, Republic of Korea
    Blood 118:5476-86. 2011
    ..Thus, NK-cell cytotoxicity is regulated, in part, by microRNA, and modulating endogenous miR-27a* levels in NK cells represents a potential immunotherapeutic strategy...
  41. pmc Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells
    Xiaohong Zhao
    Institute of Digestive Disease, Subsidary Hospital, the Medical University of Ningxia Province, Yin Chuan, Ningxia Province, China
    J Exp Clin Cancer Res 30:55. 2011
    ..Here we aimed to firstly investigate the role of miR-27a in proliferation and multidrug resistance of gastric cancer cells...
  42. doi miR-27 promotes osteoblast differentiation by modulating Wnt signaling
    Tao Wang
    Department of Orthopedics, The Sixth People s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
    Biochem Biophys Res Commun 402:186-9. 2010
    ..This study suggests miR-27 is an important mediator of osteoblast differentiation, thus offering a new target for the development of preventive or therapeutic agents against osteogenic disorders...
  43. pmc Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases
    Ravindresh Chhabra
    Functional Genomics Unit, Institute of Genomics and Integrative Biology CSIR, Mall Road, Delhi 110007, India
    Mol Cancer 9:232. 2010
    ....
  44. pmc The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin
    Brian Ell
    From the Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544
    J Biol Chem 289:21888-95. 2014
    ..These findings support a metastasis-promoting function of the miR-23b/27b/24 cluster of miRNAs, which functions in part through the direct inhibition of PSAP. ..
  45. doi rs11671784 G/A variation in miR-27a decreases chemo-sensitivity of bladder cancer by decreasing miR-27a and increasing the target RUNX-1 expression
    Ying Deng
    Department of Oncology, Sichuan Provincial People s Hospital, School of Clinical Medicine of University of Electronic Science and Technology of China, Chengdu 610000, China
    Biochem Biophys Res Commun 458:321-7. 2015
    ..In addition, RUNX-1 is a novel direct target of miR-27a, which is involved in its regulation of chemo-sensitivity in bladder cancer...
  46. pmc Primary microcephaly gene MCPH1 shows a novel molecular biomarker of human renal carcinoma and is regulated by miR-27a
    Ning Wang
    Department of Pathology, Shaoxing Hospital of Traditional Chinese Medicine Shaoxing, China
    Int J Clin Exp Pathol 7:4895-903. 2014
    ..Our study indicates for the first time that, in addition to its role in brain development, MCPH1 also functions as a tumor suppressor gene and is directly regulated by miR-27a. ..
  47. doi Genotype GG of rs895819 Functional Polymorphism Within miR-27a Might Increase Genetic Susceptibility to Colorectal Cancer in Han Chinese Population
    Yu Jiang
    Department of Clinical Laboratory, Fuzhou Second Hospital, Xiamen University, Fuzhou, Fujian, P R China
    J Clin Lab Anal 30:351-5. 2016
    ....
  48. pmc 1α,25-Dihydroxyvitamin D3 prevents the differentiation of human lung fibroblasts via microRNA-27b targeting the vitamin D receptor
    Fei Li
    Shanxi Medical University, Taiyuan, Shanxi 030001, P R China
    Int J Mol Med 36:967-74. 2015
    ..Taken together, these results suggest that 1,25(OH)2D3 inhibits lung fibroblast differentiation induced by TGF‑β1 via miR‑27b targeting VDR 3'UTR, which may be used as a novel treatment strategy in differentiation pathways. ..
  49. pmc MicroRNA-27a promotes proliferation and suppresses apoptosis by targeting PLK2 in laryngeal carcinoma
    Yuan Tian
    Department of Medical Genetics, China Medical University, Shenyang 110001, People s Republic of China
    BMC Cancer 14:678. 2014
    ..miRNA-27a has been confirmed as an important regulator in carcinogenesis and other pathological processes. Whether and how it plays a role in the laryngeal carcinoma is unknown...
  50. doi miR-27a regulates the sensitivity of breast cancer cells to cisplatin treatment via BAK-SMAC/DIABLO-XIAP axis
    Sumei Zhou
    Surgical Oncology Department, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Town, Ouhai District, Wenzhou City, Zhejiang Province, 325000, China
    Tumour Biol 37:6837-45. 2016
    ..These findings improve our understanding of the role of miR-27a in breast cancer and might provide a novel strategy for cancer therapy. ..
  51. doi MicroRNA-27a-3p regulates epithelial to mesenchymal transition via targeting YAP1 in oral squamous cell carcinoma cells
    Guang Zeng
    Department of Plastic and Burn Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi an, Shaanxi 710038, P R China
    Oncol Rep 36:1475-82. 2016
    ....
  52. doi MicroRNA variants and colorectal cancer risk: a meta-analysis
    X M Pan
    Department of Forensic Pathology, Henan University of Science and Technology, Luoyang, Henan, China
    Genet Mol Res 15:. 2016
    ..Further studies should be carried out to validate these findings...
  53. doi miR-27a suppresses EV71 replication by directly targeting EGFR
    Lianglu Zhang
    Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, No 185, Donghu Road, Wuchang District, Wuhan, 430071, China
    Virus Genes 49:373-82. 2014
    ..Moreover, the inhibition of EGFR expression by miR-27a decreased the phosphorylation of Akt and ERK, which facilitate EV71 replication. These results suggest that miR-27a may have antiviral activity against EV71 by inhibiting EGFR...
  54. doi Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population
    K Yu
    Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
    Genet Mol Res 15:. 2016
    ..The homozygous CC variant and the C allele of the rs11614913 (T>C) SNP of miR-196a2 are associated with a significantly reduced risk of ASD...
  55. doi miR-24-3p and miR-27a-3p promote cell proliferation in glioma cells via cooperative regulation of MXI1
    Weiyi Xu
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou, P R China
    Int J Oncol 42:757-66. 2013
    ..Additionally, we observed that miR‑27a‑3p is upregulated in glioma tissues...
  56. pmc Human hepatocellular carcinoma cell-specific miRNAs reveal the differential expression of miR-24 and miR-27a in cirrhotic/non-cirrhotic HCC
    Alessandro Salvi
    Department of Biomedical Sciences and Biotechnologies, Division of Biology and Genetics, University of Brescia, I 25123 Brescia, Italy
    Int J Oncol 42:391-402. 2013
    ....
  57. doi miR-27a regulates the self renewal of the H446 small cell lung cancer cell line in vitro
    Yajing Miao
    Department of Pathology, Tianjin Medical University, Tianjin 300070, PR China
    Oncol Rep 29:161-8. 2013
    ..Our results suggest that downregulation of miR-27a enhanced the stem-like properties of SCLC cells in vitro and may be critical to maintaining a stem cell function in SCLC...
  58. pmc A feedback loop consisting of microRNA 23a/27a and the β-like globin suppressors KLF3 and SP1 regulates globin gene expression
    Yanni Ma
    Department of Biochemistry, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Mol Cell Biol 33:3994-4007. 2013
    ..Hence, a positive feedback loop comprised of KLF3 and miR-23a promotes the expression of β-like globin genes and the miR-23a∼27a∼24-2 cluster during erythropoiesis. ..
  59. doi Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27
    Jennifer A Young
    Centre for the Endothelium, Vascular Biology Program, Centenary Institute, and University of Sydney, Sydney, Australia
    Blood 122:2911-9. 2013
    ..The Blockmir technology offers a refinement in the use of miRNAs, especially for therapy. Further, targeting of endothelial junctional molecules by miRNAs has clinical potential, especially in diseases associated with vascular leak. ..
  60. doi A genetic variant in pre-miR-27a is associated with a reduced breast cancer risk in younger Chinese population
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, Shandong, China
    Gene 529:125-30. 2013
    ..In conclusion, our results suggest that the SNP rs895819 may serve as a risk factor for breast cancer in younger Chinese populations; however, larger population-based studies are needed to validate these findings. ..
  61. pmc Genetic polymorphisms of miR-146a and miR-27a, H. pylori infection, and risk of gastric lesions in a Chinese population
    Ming Yang Song
    Key laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Cancer Epidemiology, Peking University Cancer Hospital and Institute, Beijing, People s Republic of China
    PLoS ONE 8:e61250. 2013
    ..pylori)-induced gastric lesions. To evaluate the associations between miRNA SNPs, H. pylori and gastric lesions, a population-based study was conducted in Linqu County, China...
  62. doi MicroRNA profiling can classify acute leukemias of ambiguous lineage as either acute myeloid leukemia or acute lymphoid leukemia
    David C de Leeuw
    Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands
    Clin Cancer Res 19:2187-96. 2013
    ..The lack of clear classification of acute leukemias of ambiguous lineage as either AML or ALL is a hurdle in treatment choice for these patients...
  63. doi Gene expression profiling indicate role of ER stress in miR-23a~27a~24-2 cluster induced apoptosis in HEK293T cells
    Ravindresh Chhabra
    Functional Genomics Unit, Institute of Genomics and Integrative Biology, Delhi, India
    RNA Biol 8:648-64. 2011
    ....
  64. doi Androgen-regulated processing of the oncomir miR-27a, which targets Prohibitin in prostate cancer
    Claire E Fletcher
    Androgen Signalling Laboratory, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK
    Hum Mol Genet 21:3112-27. 2012
    ..We further show that a miR-27a anti-sense oligonucleotide, by opposing the effects of mir-27a, has therapeutic potential in prostate cancer...
  65. pmc Lentiviral expression of anti-microRNAs targeting miR-27a inhibits proliferation and invasiveness of U87 glioma cells
    Su Y Feng
    Department of Neurosurgery, Wuxi People s Hospital of Nanjing Medical University, Wuxi 214023, PR China
    Mol Med Rep 6:275-81. 2012
    ..Collectively, these data suggest that the lentiviral expression of anti-miR-27a is a feasible approach for the suppression of malignant phenotypes of glioma cells...
  66. pmc Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing cysteine-rich protein with kazal motifs (RECK) in oral cancer
    Hyun Min Jung
    Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    J Biol Chem 287:29261-72. 2012
    ..Taken together, our data show that keratinization is associated with poor prognosis of oral cancer patients and keratinization-associated miRNAs mediate deregulation of RECK which may contribute to the aggressiveness of tumors...
  67. pmc SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster
    Erin Eun Young Ahn
    Moores UCSD Cancer Center, The University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 288:5381-8. 2013
    ..Our data revealed a previously unidentified role of SON in microRNA production via regulating the transcription process, thereby modulating GATA-2 at the protein level during hematopoietic differentiation...
  68. doi The Hsa-miR-27a rs895819 (A>G) polymorphism and cancer susceptibility
    Zexing Wang
    Department of Medical Oncology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China
    Gene 521:87-90. 2013
    ..Larger, better studies of homogeneous cancer patients are needed to further assess the correlation between this polymorphism and cancer risk...
  69. pmc Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression
    W Wang
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    Cell Death Dis 4:e574. 2013
    ..Collectively, this work reveals a direct link between the gain-of-function of mutant p53 and miRNA and uncovers a novel mutant p53-273H/miR-27a/EGFR pathway that has an important role in promoting tumor development...
  70. pmc c-MYC-regulated miR-23a/24-2/27a cluster promotes mammary carcinoma cell invasion and hepatic metastasis by targeting Sprouty2
    Xiaoni Li
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    J Biol Chem 288:18121-33. 2013
    ....
  71. pmc MicroRNA-27a regulates basal transcription by targeting the p44 subunit of general transcription factor IIH
    Maximiliano M Portal
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre national de la recherche scientifique Institut National de la Santé et de la Recherche Médicale U964, Universite de Strasbourg, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 108:8686-91. 2011
    ..This work is unique in providing a demonstration of global transcriptional regulation through the action of a single miRNA...
  72. pmc Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA
    Demian Cazalla
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 328:1563-6. 2010
    ..This viral strategy illustrates use of a ncRNA to manipulate host-cell gene expression via the miRNA pathway...

Research Grants3

  1. GENETIC POLYMORPHISM OF DIHYDROPYRIMIDINE DEHYDROGENASE
    Robert Diasio; Fiscal Year: 2006
    ..g. dihydropyrimidinase. Successful progress on this research project should translate into improved care for patients receiving fluoropyrimidine drugs in the future. ..
  2. Molecular Approach in Predicting 5-Fluorouracil Efficacy
    Robert Diasio; Fiscal Year: 2005
    ..abstract_text> ..
  3. Screening for Decreased 5-Fluorouracil Catabolism
    Robert B Diasio; Fiscal Year: 2010
    ....