MIR34A

Summary

Gene Symbol: MIR34A
Description: microRNA 34a
Alias: MIRN34A, miRNA34A, mir-34
Species: human

Top Publications

  1. pmc Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    Tsung Cheng Chang
    The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 26:745-52. 2007
  2. doi p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
    N R Christoffersen
    Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark
    Cell Death Differ 17:236-45. 2010
  3. pmc MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells
    Soichiro Yamamura
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e29722. 2012
  4. pmc Systematic proteome analysis identifies transcription factor YY1 as a direct target of miR-34a
    Qing Rong Chen
    Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland 20877, USA
    J Proteome Res 10:479-87. 2011
  5. pmc Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
    Kensuke Kumamoto
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:3193-203. 2008
  6. pmc A systematic analysis of the 3'UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites
    Andrea Wirsing
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Universitat Duisburg Essen, Essen, Germany
    PLoS ONE 6:e27438. 2011
  7. doi miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53
    Francisco Navarro
    Immune Disease Institute and Department of Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Blood 114:2181-92. 2009
  8. pmc Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
    Qing Ji
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi 710032, PR China
    BMC Cancer 8:266. 2008
  9. ncbi MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
    C Welch
    Children s Cancer Research Institute and Department of Pediatrics, The University of Texas Health Science Center at San Antonio, MC 7784, TX, USA
    Oncogene 26:5017-22. 2007
  10. ncbi Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
    Nina Raver-Shapira
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell 26:731-43. 2007

Scientific Experts

Detail Information

Publications105 found, 100 shown here

  1. pmc Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    Tsung Cheng Chang
    The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 26:745-52. 2007
    ..Therefore, it is likely that an important function of miR-34a is the modulation and fine-tuning of the gene expression program initiated by p53...
  2. doi p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
    N R Christoffersen
    Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark
    Cell Death Differ 17:236-45. 2010
    ..Hence, in addition to its integration in the p53 pathway, we show that alternative cancer-related pathways regulate miR-34a, emphasising its significance as a tumour suppressor...
  3. pmc MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells
    Soichiro Yamamura
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e29722. 2012
    ....
  4. pmc Systematic proteome analysis identifies transcription factor YY1 as a direct target of miR-34a
    Qing Rong Chen
    Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland 20877, USA
    J Proteome Res 10:479-87. 2011
    ..YY1 is a negative regulator of p53, and it plays an essential role in cancer biology. Therefore, YY1 is another important direct target of miR-34a which closely regulates TP53 activities...
  5. pmc Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
    Kensuke Kumamoto
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:3193-203. 2008
    ..together, we conclude that nutlin-3a induces senescence through p53 activation in normal human fibroblasts, and p53-mediated mir34a, mir34b, and mir34c up-regulation and ING2 down-regulation may be involved in the senescence pathway.
  6. pmc A systematic analysis of the 3'UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites
    Andrea Wirsing
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Universitat Duisburg Essen, Essen, Germany
    PLoS ONE 6:e27438. 2011
    ..The identification of several regulatory elements within the HNF4A 3'UTR justifies the analysis of the 3'UTR sequence to explore the dysfunction of HNF4α in diabetes and RCC...
  7. doi miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53
    Francisco Navarro
    Immune Disease Institute and Department of Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Blood 114:2181-92. 2009
    ..However, in p53-null K562 cells, phorbol esters induce miR-34a expression independently of p53 by activating an alternative phorbol ester-responsive promoter to produce a longer pri-miR-34a transcript...
  8. pmc Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
    Qing Ji
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi 710032, PR China
    BMC Cancer 8:266. 2008
    ..The role of miR-34 in gastric cancer has not been reported previously. In this study, we examined the effects of miR-34 restoration on p53-mutant human gastric cancer cells and potential target gene expression...
  9. ncbi MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
    C Welch
    Children s Cancer Research Institute and Department of Pediatrics, The University of Texas Health Science Center at San Antonio, MC 7784, TX, USA
    Oncogene 26:5017-22. 2007
    ..Thus, adding to the increasing role of miRNAs in cancer, miR-34a may act as a suppressor of NB tumorgenesis...
  10. ncbi Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
    Nina Raver-Shapira
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell 26:731-43. 2007
    ..Perturbation of miR-34a expression, as occurs in some human cancers, may thus contribute to tumorigenesis by attenuating p53-dependent apoptosis...
  11. ncbi Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest
    Valery Tarasov
    Molecular Oncology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Cell Cycle 6:1586-93. 2007
    ..siRNAs corresponding to p53-induced miRNAs may have potential as cancer therapeutic agents as RNA interference based therapies are currently emerging...
  12. pmc Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
    Hiroshi Tazawa
    Biochemistry Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Proc Natl Acad Sci U S A 104:15472-7. 2007
    ..Abrogation of miR-34a function could contribute to aberrant cell proliferation, leading to colon cancer development...
  13. ncbi Association of microRNA-34a overexpression with proliferation is cell type-dependent
    Khokon Kumar Dutta
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cancer Sci 98:1845-52. 2007
    ....
  14. doi Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest
    Fang Sun
    Beijing Institute of Radiation Medicine, Beijing, People s Republic of China
    FEBS Lett 582:1564-8. 2008
    ..Taken together, our data suggest that the effects of miR-34a on G1 cell cycle arrest are through the down-regulation of CCND1 and CDK6, which is associated with other targets of miR-34a either additively or synergistically...
  15. pmc The MYCN oncogene is a direct target of miR-34a
    J S Wei
    Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, Gaithersburg, MD 20892, USA
    Oncogene 27:5204-13. 2008
    ..This study demonstrates one important regulatory role of miR-34a in cell growth and MYCN suppression in neuroblastoma...
  16. pmc A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene
    Kristina A Cole
    Division of Oncology, Children s Hospital of Philadelphia, Abramson Pediatric Research Center 902A, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    Mol Cancer Res 6:735-42. 2008
    ..BCL2 and MYCN were identified as miR-34a targets and likely mediators of the tumor suppressor phenotypic effect. These data support miR-34a as a tumor suppressor gene in human neuroblastoma...
  17. ncbi Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
    Dmitri Lodygin
    Molecular Oncology, Max Planck Institute of Biochemistry, Martinsried, Germany
    Cell Cycle 7:2591-600. 2008
    ..These results show that miR-34a represents a tumor suppressor gene which is inactivated by CpG methylation and subsequent transcriptional silencing in a broad range of tumors...
  18. pmc miR-34a repression of SIRT1 regulates apoptosis
    Munekazu Yamakuchi
    Departments of Medicine and Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:13421-6. 2008
    ..Finally, miR-34a itself is a transcriptional target of p53, suggesting a positive feedback loop between p53 and miR-34a. Thus, miR-34a functions as a tumor suppressor, in part, through a SIRT1-p53 pathway...
  19. doi Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells
    Yasunori Fujita
    Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Biochem Biophys Res Commun 377:114-9. 2008
    ....
  20. doi miR-34a as part of the resistance network in chronic lymphocytic leukemia
    Thorsten Zenz
    Department of Internal Medicine III, University of Ulm, Ulm, Germany
    Blood 113:3801-8. 2009
    ..The elucidation of mechanisms underlying miR-34a regulation and overcoming its role in chemotherapy resistance warrant further study...
  21. doi miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells
    Na Li
    Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, PR China
    Cancer Lett 275:44-53. 2009
    ..Taken together, these results provide evidence to show the suppression role of miR-34a in tumor migration and invasion through modulation of the c-Met signaling pathway...
  22. pmc Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6
    Xiaohong Wang
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    RNA 15:637-47. 2009
    ..Together, this is the first time a viral oncoprotein has been shown to regulate cellular miRNA expression. Our data have provided new insights into mechanisms by which high-risk HPVs contribute to the development of cervical cancer...
  23. pmc MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation
    Sara T Hashimi
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Blood 114:404-14. 2009
    ..Thus, our novel approach identified and validated some miRNA-protein networks involved in phenotypic and functional MDDC differentiation...
  24. doi The miR-34 family in cancer and apoptosis
    H Hermeking
    Experimental and Molecular Pathology, Institute of Pathology, Ludwig Maximilians University Munich, Thalkirchner Str 36, D 80337 Munich, Germany
    Cell Death Differ 17:193-9. 2010
    ..In this review, the evidence for a role of miR-34a and miR-34b/c in the apoptotic response of normal and tumor cells is surveyed...
  25. doi Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples
    Chunlei He
    Guangzhou Medical College, Guangdong Province, China
    Biochem Biophys Res Commun 388:35-40. 2009
    ..Expression of MiR-34s was decreased in tumor samples, and MiR-34 genes underwent minimal deletions and epigenetic inactivation in osteosarcomas...
  26. pmc MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
    Qing Ji
    Department of Radiation Oncolog, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 4:e6816. 2009
    ..Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2, suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells...
  27. doi miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer
    Elena Gallardo
    Department of Medical Oncology, Hospital Clinic, Institut d Investigacions Biomédiques, Agust Pi i Sunyer, 08036 Barcelona, Spain
    Carcinogenesis 30:1903-9. 2009
    ..addition, in patients with sufficient tumor tissue, we assessed p53 mutations and the methylation status of the MIRN34A gene promoter region and correlated these findings with miR-34a expression...
  28. doi microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia
    Daniela Asslaber
    Laboratory for Immunological and Molecular Cancer Research, 3rd Medical Department of Hematology, Medical Oncology, Hemostaseology, Rheumatology and Infectiology, Paracelsus Medical University Salzburg, Salzburg, Austria
    Blood 115:4191-7. 2010
    ..Further, overexpression of miR-34a in primary B-CLL cells induced apoptosis. These findings suggest miR-34a as a possible therapeutic avenue and a sensitive indicator of the activity of the p53 axis in B-CLL...
  29. doi Epigenetic inactivation of the miR-34a in hematological malignancies
    C S Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China
    Carcinogenesis 31:745-50. 2010
    ....
  30. doi The impact of miR-34a on protein output in hepatocellular carcinoma HepG2 cells
    Jun Cheng
    Key Laboratory of Combined Multi organ Transplantation, Ministry of Public Health, Hangzhou, PR China
    Proteomics 10:1557-72. 2010
    ..Cytoskeletal proteins such as LMNA, GFAP, MACF1, ALDH2, and LOC100129335 are potential targets of miR-34a. In conclusion, abrogation of miR-34a function could cause downstream molecules to switch on or off, leading to HCC development...
  31. pmc microRNA-34a is tumor suppressive in brain tumors and glioma stem cells
    Fadila Guessous
    Department of Microbiology, University of Virginia, Charlottesville, VA, USA
    Cell Cycle 9:1031-6. 2010
    ..Altogether, the data suggest that miR-34a is a tumor suppressor and a potential potent therapeutic agent that acts by targeting multiple oncogenic pathways in brain tumors and by inducing the differentiation of cancer stem cells...
  32. doi MicroRNA-34a inhibits cell proliferation by repressing mitogen-activated protein kinase kinase 1 during megakaryocytic differentiation of K562 cells
    Atsuhiko Ichimura
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho Sakyo ku, Kyoto 606 8501, Japan
    Mol Pharmacol 77:1016-24. 2010
    ..Thus, the results highlight an important regulatory role for miR-34a in the process of megakaryocytic differentiation, especially in the arrest of cell growth, which is a prerequisite for cells to enter differentiation...
  33. doi MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells
    Ronald T K Pang
    Department of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam Road, Hong Kong, People s Republic of China
    Carcinogenesis 31:1037-44. 2010
    ..Our results provide evidence that miR-34a inhibits invasiveness through regulation of the Notch pathway and its downstream matrix degrading enzyme...
  34. doi MicroRNA-34a: a novel tumor suppressor in p53-mutant glioma cell line U251
    Shihai Luan
    Department of Neurosurgery, Huashan Hospital of Fudan University, Shanghai, China
    Arch Med Res 41:67-74. 2010
    ..MiR-34a was identified to represent the status of p53 and participate in initiation and progress of cancers. We undertook this study to investigate the role of miR-34a in glioma cells...
  35. doi Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells
    Yukihiro Akao
    Gifu University, Yanagido, Japan
    Cancer Lett 300:197-204. 2011
    ..These findings suggest that miR-34a targeting the Sirt1 and E2F3 genes could negatively regulate, at least in part, the resistance to 5-FU in human colorectal cancer DLD-1 cells...
  36. pmc miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma
    Shyamal D Weeraratne
    Department of Neurology, Children s Hospital Boston Harvard Medical School, 3 Blackfan Circle, CLS 14072, Boston, MA 02115, USA
    Neuro Oncol 13:165-75. 2011
    ..Our work establishes a role for miR-34a in modulating responsiveness to chemotherapy in medulloblastoma and presents a novel positive feedback mechanism involving miR-34a and p53, via direct targeting of MAGE-A...
  37. doi Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas
    Markus Vogt
    Institute of Pathology, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789, Bochum, Germany
    Virchows Arch 458:313-22. 2011
    ..The mutual exclusiveness of miR-34a methylation and p53 mutation indicates that miR-34a inactivation may substitute for loss of p53 function in cancer...
  38. doi miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells
    Giorgio Zauli
    Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
    Clin Cancer Res 17:2712-24. 2011
    ..To elucidate new molecular mechanisms able to downregulate the mRNA levels of key oncogenes, such as B-Myb and E2F1, in a therapeutic perspective...
  39. pmc Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis
    Markus Kaller
    Experimental and Molecular Pathology, Institute of Pathology, Ludwig Maximilians University Munich, Thalkirchner Strasse 36, D 80337 Munich, Germany
    Mol Cell Proteomics 10:M111.010462. 2011
    ..In summary, miR-34a presumably participates in multiple tumor suppressive pathways by directly and indirectly suppressing the expression of numerous, critical proteins...
  40. pmc miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner
    Nora Bandi
    Institute of Pathology, University of Bern, Bern, Switzerland
    Mol Cancer 10:55. 2011
    ..The aim of this study was to investigate the combined action of miR-34a and miR-15a/16 in non-small cell lung cancer (NSCLC) cells...
  41. pmc Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells
    Dara Nalls
    Departments of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e24099. 2011
    ....
  42. pmc MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma
    Pasqualino De Antonellis
    Centro di Ingegneria Genetica e Biotecnologia Avanzate, CEINGE, Naples, Italy
    PLoS ONE 6:e24584. 2011
    ..On the basis of this evidence, we hypothesized that miRNAs targeting the Notch pathway can regulate these phenomena, and can be used in anti-cancer therapies...
  43. doi miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy
    Fumihiko Nakatani
    Laboratory of Experimental Oncology, Rizzoli Institute, Bologna, Italy
    J Pathol 226:796-805. 2012
    ..High expression of miR34a can be detected also in paraffin-embedded tissues by in situ hybridization, thus contributing to an easy routine ..
  44. pmc A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
    Nam Hee Kim
    Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University, Seoul 120 752, South Korea
    J Cell Biol 195:417-33. 2011
    ..These results identify a new link between p53, miR-34, and Snail1 in the regulation of cancer cell EMT programs...
  45. pmc p53 and microRNA-34 are suppressors of canonical Wnt signaling
    Nam Hee Kim
    Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry, Yonsei University, Seoul 120 752, Korea
    Sci Signal 4:ra71. 2011
    ..These data provide insight into the mechanisms by which a p53-miR-34 network restrains canonical Wnt signaling cascades in developing organisms and human cancer...
  46. pmc Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling
    Ashish Lal
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002363. 2011
    ..Thus miR-34a tempers the proliferative and pro-survival effect of growth factor stimulation by interfering with growth factor signal transduction and downstream pathways required for cell division...
  47. doi miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    Helge Siemens
    Experimental and Molecular Pathology, Institute of Pathology, Ludwig Maximilians University Munich, Munich, Germany
    Cell Cycle 10:4256-71. 2011
    ..In conclusion, the frequent inactivation of p53 and/or miR-34a/b/c found in cancer may shift the equilibrium of these reciprocal regulations towards the mesenchymal state and thereby lock cells in a metastatic state...
  48. doi Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: a review
    Fei Chen
    Department of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People s Republic of China
    J Biochem Mol Toxicol 26:79-86. 2012
    ..Ectopic miR-34a expression induces apoptosis, cell cycle arrest, and differentiation or reduces migration. This review summarizes the progress regarding the role of miR-34a in cell cycle, differentiation, and apoptosis...
  49. doi Analysis of the miR-34a locus in 62 patients with familial cutaneous melanoma negative for CDKN2A/CDK4 screening
    Angela M Cozzolino
    Medical Genetics, Department of Molecular Medicine, San Camillo Forlanini Hospital, Sapienza University, Circonvallazione Gianicolense, 87, 00152, Rome, Italy
    Fam Cancer 11:201-8. 2012
    ..A function as phenotypic modulator in familial melanoma cannot be excluded...
  50. doi MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1
    Jianmin Wu
    Institute of Genomic Medicine, Wenzhou Medical College, 268 Xueyuan Road, Wenzhou, Zhejiang 325000, People s Republic of China
    Carcinogenesis 33:519-28. 2012
    ..However, in vivo data indicate that the p53-miR-34a pathway is not the major regulator of Fra-1 expression in human colon cancer tissues...
  51. doi miR-34a expression, cell cycle arrest and cell death of malignant mesothelioma cells upon treatment with radiation, docetaxel or combination treatment
    Taha Ghawanmeh
    Department of Oncology, Rudbeck Laboratory, Uppsala University Hospital, Uppsala, Sweden
    Oncology 81:330-5. 2011
    ..Malignant mesothelioma (MM) is a highly aggressive tumour related to asbestos exposure. Histopathologically, the tumour is classified as epithelial, sarcomatoid or biphasic. To date, MM is still an incurable disease...
  52. pmc p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells
    Abhinav K Jain
    Program in Genes and Development, Center for Stem Cell and Development Biology, Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    PLoS Biol 10:e1001268. 2012
    ..These studies underscore the importance of a p53-regulated network in determining the human stem cell state...
  53. pmc MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo
    Kang Yan
    Department of Orthopedic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    PLoS ONE 7:e33778. 2012
    ..In the present study, the effects of miR-34a on osteosarcoma and the possible mechanism by which miR-34a affected the tumor growth and metastasis of osteosarcoma were investigated...
  54. pmc Dysregulation of microRNA-34a expression in head and neck squamous cell carcinoma promotes tumor growth and tumor angiogenesis
    Bhavna Kumar
    Department of Otolaryngology Head and Neck Surgery, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 7:e37601. 2012
    ..miR-34a is a tumor-suppressor that is frequently downregulated in a number of tumor types. However, little is known about the role of miR-34a in head and neck squamous cell carcinoma (HNSCC)...
  55. pmc MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame
    Pooja Mandke
    Department of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio, United States of America
    PLoS ONE 7:e42034. 2012
    ..We have reported that DNA damage triggers loss of MDM4 mRNA and a concurrent increase in p53 activity. These experiments attempt to determine a mechanism for down-regulation of MDM4 mRNA...
  56. doi miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
    Rui E Castro
    Research Institute for Medicines and Pharmaceutical Sciences iMED UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
    J Hepatol 58:119-25. 2013
    ..Here, we aimed at evaluating the miR-34a/Sirtuin 1(SIRT1)/p53 pro-apoptotic pathway in human NAFLD, and to elucidate its function and modulation by UDCA in the rat liver and primary rat hepatocytes...
  57. pmc TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma
    Pengyuan Yang
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 22:291-303. 2012
    ....
  58. pmc Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF
    Sanchita Roy
    Department of Veterans Affairs Medical Center, Wayne State University, Detroit, MI 48201, USA
    J Hematol Oncol 5:58. 2012
    ..Numerous cellular events, including deregulated expression of microRNAs (miRNAs), specifically the family of miR-34 consisting of miR-34a, b and c, is known to regulate the processes of growth and metastasis...
  59. doi MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1
    S Yang
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Oncogene 32:4294-303. 2013
    ..Our results demonstrate that miR-34a/c functions as a metastasis suppressor to regulate breast cancer migration and invasion through targeting Fra-1 oncogene and suggest a therapeutic application of miR-34 in breast cancer...
  60. doi microRNA-34a sensitizes lung cancer cell lines to DDP treatment independent of p53 status
    Xi Wang
    Department of Clinical Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Cancer Biother Radiopharm 28:45-50. 2013
    ....
  61. pmc MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1
    Ronald Tk Pang
    Department of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    BMC Cancer 13:25. 2013
    ..MicroRNAs (miRNAs) are small non protein-coding RNAs which inhibit target gene expression. The role of miRNAs in choriocarcinoma, however, is not well understood. In this study, we examined the effect of miR-34a in choriocarcinoma...
  62. pmc Ectopic expression of miR-34a enhances radiosensitivity of non-small cell lung cancer cells, partly by suppressing the LyGDI signaling pathway
    Weiming Duan
    School of Radiation Medicine and Public Health, Soochow University, Suzhou, Jiangsu 215123, China
    J Radiat Res 54:611-9. 2013
    ....
  63. doi Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients
    Annika Dufour
    Laboratory for Leukemia Diagnostics, Department of Medicine III, Grosshadern Hospital, Ludwig Maximilians University, Munich, Germany
    Blood 121:3650-7. 2013
    ..In addition, only a complete loss of TP53 function correlated with low microRNA-34a expression levels. This trial was registered at www.clinicaltrials.gov as #NCT00090051...
  64. doi Thyroid hormone inhibits TGFβ1 induced renal tubular epithelial to mesenchymal transition by increasing miR34a expression
    Xiaozhao Lu
    Department of Nephrology, 323 Hospital of PLA, Xi an 710054, PR China
    Cell Signal 25:1949-54. 2013
    ..Meanwhile, T3 induced the expression of miR34a. Molecularly, the T3 receptor could directly bind the T3R recognition motif at the -1505 to -1526bp and -604 to -..
  65. pmc A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells
    Jonathan M Locke
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, Barrack Road, Exeter, EX2 5DW, UK
    Acta Diabetol 51:325-9. 2014
    ..Given that small changes in miR-34a levels have been shown to cause increased levels of beta-cell apoptosis this finding may be of interest to studies looking at determining the effect of rare variants on type 2 diabetes susceptibility...
  66. pmc TP53-independent function of miR-34a via HDAC1 and p21(CIP1/WAF1.)
    Jane Zhao
    Mirna Therapeutics, Inc, Austin, Texas 78744, USA
    Mol Ther 21:1678-86. 2013
    ..The data suggest that miR-34 controls a tumor suppressor pathway previously reserved for TP53 and provides an attractive therapeutic strategy for cancer patients irrespective of TP53 status...
  67. pmc A miR-34a-SIRT6 axis in the squamous cell differentiation network
    Karine Lefort
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    EMBO J 32:2248-63. 2013
    ..The findings are of likely biological significance, as SIRT6 is oppositely expressed to miR-34a in normal keratinocytes and keratinocyte-derived tumours. ..
  68. pmc MicroRNA-34a suppresses cell proliferation by targeting LMTK3 in human breast cancer mcf-7 cell line
    Guoqing Zhao
    1 Tissue Bank, China Japan Union Hospital, Jilin University, Changchun, China
    DNA Cell Biol 32:699-707. 2013
    ..Taken together, these results suggest that miR-34a inhibits breast cancer proliferation by targeting LMTK3 and might be used as an anti-ERα agent in breast cancer therapy. ..
  69. doi miR-34a regulates cisplatin-induce gastric cancer cell death by modulating PI3K/AKT/survivin pathway
    Weiguo Cao
    Department of Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Tumour Biol 35:1287-95. 2014
    ..miR-34a over-expression could improve the sensitivity of gastric cancer cells against cisplatin-based chemotherapies, with PI3K/AKT/survivin signaling pathway possibly involved in the mechanism...
  70. doi Roles of microRNA-34a in the pathogenesis of placenta accreta
    Kota Umemura
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan
    J Obstet Gynaecol Res 39:67-74. 2013
    ..The trophoblastic cells of placenta accreta invade into the myometrium in a similar way to the invasion of cancers. We studied the roles of miR-34a in the pathogenesis of placenta accreta...
  71. doi Downregulation of microRNA-34 induces cell proliferation and invasion of human mesothelial cells
    Norimitsu Tanaka
    Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Oncol Rep 29:2169-74. 2013
    ..The present study, together with the results of our previous report, strongly suggest that miR-34s play an important role in the early carcinogenic process involved in the transformation of human mesothelial cells to MM...
  72. pmc MicroRNA-34a inhibits human osteosarcoma proliferation by downregulating ether à go-go 1 expression
    Xinyu Wu
    Department of Neurology, the Affiliated Southeast Hospital of Xiamen University, Zhangzhou 363000, China
    Int J Med Sci 10:676-82. 2013
    ..Taken together, our results suggest that miR-34a could inhibit osteosarcoma growth via the down regulation of Eag1 expression...
  73. doi Circulating miR-22, miR-24 and miR-34a as novel predictive biomarkers to pemetrexed-based chemotherapy in advanced non-small cell lung cancer
    Tindara Franchina
    Unit of Medical Oncology, A O O R Papardo Piemonte and Department of Human Pathology, University of Messina, Messina, Italy
    J Cell Physiol 229:97-9. 2014
    ..The correlation between high expression of miR-22 in whole blood and the lack of response in pemetrexed treated NSCLC patients indicates that miR-22 could represent a novel predictive biomarker for pemetrexed-based treatment...
  74. doi p53 regulates glucose metabolism by miR-34a
    Hwa Ryeon Kim
    National Creative Research Center for Epigenome Reprogramming Network, Departments of Biomedical Sciences and Biochemistry and Molecular Biology, Ischemic Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul 110 799, Republic of Korea
    Biochem Biophys Res Commun 437:225-31. 2013
    ..miR-34a-mediated inhibition of these enzymes resulted in repressed glycolysis and enhanced mitochondrial respiration. The results suggest that p53 has a miR-34a-dependent integrated mechanism to regulate glucose metabolism. ..
  75. doi MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme
    Wen bo Li
    Tianjin Medical University Eye Center, China
    Cancer Biol Ther 12:477-83. 2011
    ..Knockdown of notch1 showed similar cellular functions as overexpression of miR-34a both in vitro and in vivo. Collectively, our findings show that miR-34a is downregulated in GBM cells and inhibits GBM growth by targeting notch1...
  76. pmc Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms
    Chor Sang Chim
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    J Transl Med 9:197. 2011
    ..MicroRNA (miR) miR-34a, -34b/c, -124-1 and -203 are tumor suppressor miRs implicated in carcinogenesis...
  77. pmc MiR-34a expression has an effect for lower risk of metastasis and associates with expression patterns predicting clinical outcome in breast cancer
    Hanna Peurala
    Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    PLoS ONE 6:e26122. 2011
    ....
  78. doi MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma
    Nigel B Jamieson
    West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, United Kingdom
    Clin Cancer Res 18:534-45. 2012
    ..We sought to establish the relationship between miRNA expression and clinicopathologic parameters, including prognosis, in pancreatic ductal adenocarcinoma (PDAC)...
  79. doi A p53-inducible microRNA-34a downregulates Ras signaling by targeting IMPDH
    Hwa Ryeon Kim
    National Research Laboratory for Metabolic Checkpoint, Departments of Biomedical Sciences and Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 110 799, Republic of Korea
    Biochem Biophys Res Commun 418:682-8. 2012
    ..In summary, we suggest that p53 has a novel function in regulating purine biosynthesis, aided by miR-34a-dependent IMPDH repression...
  80. pmc Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells
    Rui Du
    Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi an, People s Republic China
    PLoS ONE 7:e30771. 2012
    ..MicroRNAs (miRNAs) are small non-coding RNA molecules that bind to their mRNA targets, thereby leading to translational repression. The role of miRNA in hypoxia-induced EMT is largely unknown...
  81. doi MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression
    Tsuyoshi Tabuchi
    Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine, Iwate, Japan
    Clin Sci (Lond) 123:161-71. 2012
    ....
  82. pmc The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells
    Eleonora Forte
    Department of Molecular Genetics and Microbiology, Center for Virology, Duke University Medical Center, Durham, North Carolina, USA
    J Virol 86:6889-98. 2012
    ..This study identifies a progrowth role for a tumor-suppressive miRNA in oncogenic-virus-mediated transformation, highlighting the importance of studying miRNA function in different cellular contexts...
  83. ncbi MicroRNA-34a suppresses cell proliferation and induces apoptosis in U87 glioma stem cells
    Lihua Sun
    Department of Neurosurgery, the Affiliated Wuxi People s Hospital of Nanjing Medical University, Wuxi 214023, PR China
    Technol Cancer Res Treat 11:483-90. 2012
    ..These findings suggest that miR-34a acts as a tumor suppressor in U87 GSCs. Therefore, this observation highlights a new potential therapeutic agent for GSC-based glioma treatment...
  84. doi miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis
    Takenori Ogawa
    Department of Molecular Pathology, Tohoku University School of Medicine, Miyagi, Japan
    Cancer Sci 103:1737-43. 2012
    ..These results strongly suggest that miR-34a expression can be an independent prognostic biomarker in patients with sinonasal squamous cell carcinoma who are undergoing treatment with cis-diamminedichloroplatinum...
  85. doi Micro-RNA-34a contributes to the impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease
    Quanfu Xu
    Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany
    J Am Coll Cardiol 59:2107-17. 2012
    ..This study evaluated the regulation and function of micro-RNAs (miRs) in bone marrow-mononuclear cells (BMCs)...
  86. pmc Epigenetic regulation of miR-34a expression in alcoholic liver injury
    Fanyin Meng
    Department of Medicine, Scott and White Digestive Disease Research Center, Texas A and M Health Science Center College of Medicine, Temple, USA
    Am J Pathol 181:804-17. 2012
    ..These findings provide the basis for an exciting field in which the epigenomic microRNAs of hepatic cells may be manipulated with potential therapeutic benefits in human alcoholic liver diseases...
  87. pmc Associations between microRNA expression and mesenchymal marker gene expression in glioblastoma
    Xinlong Ma
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neuro Oncol 14:1153-62. 2012
    ..Mesenchymal signaling in GBM may be negatively regulated by miR-128a and -504...
  88. pmc microRNA miR-34a regulates cytodifferentiation and targets multi-signaling pathways in human dental papilla cells
    Mian Wan
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, China
    PLoS ONE 7:e50090. 2012
    ..Findings from these studies suggested that miR-34a may play important roles in dental papilla cell differentiation during human tooth development by targeting NOTCH and TGF-beta signaling...
  89. pmc The role of microRNAs in hepatocyte nuclear factor-4alpha expression and transactivation
    Zhongyan Wang
    Department of Surgery, Boston University School of Medicine, Boston, MA 02118, USA
    Biochim Biophys Acta 1829:436-42. 2013
    ....
  90. doi Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction
    Sen Matsumoto
    Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circ Res 113:322-6. 2013
    ..Although various microRNAs have been proposed as diagnostic indicators for AMI, no microRNAs have been established as predictors of ischemic HF that develops after AMI...
  91. doi MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtypes
    Marek Mraz
    Center of Molecular Biology and Gene Therapy, Department of Internal Medicine Hematooncology, University Hospital Brno and Medical Faculty MU, Brno, Czech Republic
    Leuk Lymphoma 50:506-9. 2009
    ..Consequently, these three miRNAs could potentially play important roles in the pathogenesis of aggressive CLL...
  92. doi Differential microRNA-34a expression and tumor suppressor function in retinoblastoma cells
    Clifton L Dalgard
    Ocular Oncology Unit, Department of Ophthalmology, University of California at San Francisco, San Francisco, California 94143, USA
    Invest Ophthalmol Vis Sci 50:4542-51. 2009
    ..The role of miR-34a, a p53-regulated microRNA, in retinoblastoma (RB) was investigated...
  93. doi Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial
    Thorsten Zenz
    Department of Internal Medicine III, University of Ulm, Ulm, Germany
    Blood 114:2589-97. 2009
    ..Alemtuzumab is effective irrespective of genetic high-risk subgroups with TP53 mutations. These clinical trials are registered at www.clinicaltrials.gov as #NCT00274976...
  94. pmc MicroRNA-34a is an important component of PRIMA-1-induced apoptotic network in human lung cancer cells
    Wenrui Duan
    The Ohio State University College of Medicine and Public Health, Columbus, OH, USA
    Int J Cancer 127:313-20. 2010
    ..Knockdown microRNA-34a decreased the rate of apoptosis caused by PRIMA-1. The above results suggest that microRNA-34a is one of the important components of PRIMA-1-induced apoptotic network in the cancer cells harboring mutant p53...
  95. pmc MicroRNA regulation of IFN-beta protein expression: rapid and sensitive modulation of the innate immune response
    Kenneth W Witwer
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    J Immunol 184:2369-76. 2010
    ..Thus, miRNAs may contribute significantly to the regulation of IFN-beta in innate immune responses...
  96. doi Reduced miR-34a expression in normal cervical tissues and cervical lesions with high-risk human papillomavirus infection
    Baohua Li
    Women s Reproductive Health Key Laboratory of Zhejiang Province, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Int J Gynecol Cancer 20:597-604. 2010
    ..Our study aimed to ascertain the possibility of pri-miR-34a involved in the development of cervical lesions and to explore the mechanism of altered pri-miR-34a expression induced by HPV-16 E6...
  97. ncbi [miR-34s--a tumor suppression protein p53 highly related microRNA]
    Wen Jia Lou
    Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci Tech University, Hangzhou 310018, China
    Yi Chuan 32:423-30. 2010
    ..This paper summarizes the latest advances of p53 highly related miR-34 families in oncogenesis and treatment...
  98. doi MicroRNA-34a regulation of endothelial senescence
    Takashi Ito
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, West Henrietta, NY 14586, USA
    Biochem Biophys Res Commun 398:735-40. 2010
    ..Our data suggest that miR-34a contributes to endothelial senescence through suppression of SIRT1...
  99. pmc Controlling SIRT1 expression by microRNAs in health and metabolic disease
    Jiyoung Lee
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana Champaign, IL 61801, USA
    Aging (Albany NY) 2:527-34. 2010
    ..The FXR/miR-34a pathway and other miRs controlling SIRT1 may be useful therapeutic targets for age-related diseases, including metabolic disorders...