MITF

Summary

Gene Symbol: MITF
Description: melanogenesis associated transcription factor
Alias: CMM8, COMMAD, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, class E basic helix-loop-helix protein 32, microphtalmia-associated transcription factor
Species: human

Top Publications

  1. pmc The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 signaling
    Jolyon Terragni
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 286:36215-27. 2011
  2. pmc Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-β
    Marie Jeanne Pierrat
    Institut Curie, Centre de Recherche, INSERM U1021, CNRS UMR3347, and Université Paris XI, 91400 Orsay, France
    J Biol Chem 287:17996-8004. 2012
  3. pmc Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, Oxted, Surrey, RH8 0TL, United Kingdom
    Genes Dev 20:3426-39. 2006
  4. pmc MiTF links Erk1/2 kinase and p21 CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells
    Feng Liu
    Department of Medicine, University of California Irvine School of Medicine, Orange, CA 92868, USA
    Mol Cancer 9:214. 2010
  5. pmc Inhibition of coding region determinant binding protein sensitizes melanoma cells to chemotherapeutic agents
    Evisabel A Craig
    Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Pigment Cell Melanoma Res 25:83-7. 2012
  6. ncbi The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter
    Kim C Mansky
    Department of Molecular Genetics, Ohio State University Columbus 43210, USA
    J Leukoc Biol 71:304-10. 2002
  7. doi MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines
    Lynne T Bemis
    Division of Medical Oncology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Cancer Res 68:1362-8. 2008
  8. pmc Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF
    Claudia Wellbrock
    Signal Transduction Team, The Institute of Cancer Research, Cancer Research UK Centre of Cell and Molecular Biology, London, United Kingdom
    PLoS ONE 3:e2734. 2008
  9. ncbi The melanocyte-specific isoform of the microphthalmia transcription factor affects the phenotype of human melanoma
    Edgar Selzer
    Department of Radiotherapy and Radiobiology, University Hospital Vienna, 1090 Vienna, Austria
    Cancer Res 62:2098-103. 2002
  10. pmc Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation
    Claudia Wellbrock
    Signal Transduction Team, Cancer Research UK Centre of Cell and Molecular Biology, The Institute of Cancer Research, London SW3 6JB, England, UK
    J Cell Biol 170:703-8. 2005

Research Grants

  1. Role of TRPM1 (Melastatin1) in the Biology of Human Melanocytes
    Vijayasaradhi Setaluri; Fiscal Year: 2012
  2. John A D'Orazio; Fiscal Year: 2016
  3. Ivana L de la Serna; Fiscal Year: 2014
  4. ATF2 in melanoma development and progression
    ZE apos EV A RONAI; Fiscal Year: 2012
  5. David E Fisher; Fiscal Year: 2016
  6. Eva Hernando; Fiscal Year: 2016
  7. CHARLES KORE KAUFMAN; Fiscal Year: 2015
  8. Vladimir S Spiegelman; Fiscal Year: 2016
  9. ROBERT AARON CORNELL; Fiscal Year: 2014
  10. Aldehyde dehydrogenase: A novel regulator of melanin biogenesis
    Anand K Ganesan; Fiscal Year: 2013

Detail Information

Publications219 found, 100 shown here

  1. pmc The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 signaling
    Jolyon Terragni
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 286:36215-27. 2011
    ..Inhibition of PI 3-kinase led to a loss of Max/Mnt binding and transcriptional induction by MITF and USF1, as well as FoxO...
  2. pmc Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-β
    Marie Jeanne Pierrat
    Institut Curie, Centre de Recherche, INSERM U1021, CNRS UMR3347, and Université Paris XI, 91400 Orsay, France
    J Biol Chem 287:17996-8004. 2012
    The melanocyte-specific transcription factor M-MITF is involved in numerous aspects of melanoblast lineage biology including pigmentation, survival, and migration...
  3. pmc Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, Oxted, Surrey, RH8 0TL, United Kingdom
    Genes Dev 20:3426-39. 2006
    ..in melanomas invasiveness can be regulated epigenetically by the microphthalmia-associated transcription factor, Mitf, via regulation of the DIAPH1 gene encoding the diaphanous-related formin Dia1 that promotes actin polymerization ..
  4. pmc MiTF links Erk1/2 kinase and p21 CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells
    Feng Liu
    Department of Medicine, University of California Irvine School of Medicine, Orange, CA 92868, USA
    Mol Cancer 9:214. 2010
    As a survival factor for melanocytes lineage cells, MiTF plays multiple roles in development and melanomagenesis. What role MiTF plays in the DNA damage response is currently unknown...
  5. pmc Inhibition of coding region determinant binding protein sensitizes melanoma cells to chemotherapeutic agents
    Evisabel A Craig
    Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Pigment Cell Melanoma Res 25:83-7. 2012
    ..Furthermore, inhibition of CRD-BP decreases microphthalmia-associated transcription factor (MITF) expression and reintroduction of MITF partially compensates for the absence of CRD-BP...
  6. ncbi The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter
    Kim C Mansky
    Department of Molecular Genetics, Ohio State University Columbus 43210, USA
    J Leukoc Biol 71:304-10. 2002
    The microphthalmia transcription factor (MITF) regulates different target genes in several distinct cell types, including osteoclasts. The role of the closely related factors TFE3 and TFEC in MITF action was studied...
  7. doi MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines
    Lynne T Bemis
    Division of Medical Oncology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Cancer Res 68:1362-8. 2008
    Micropthalmia-associated transcription factor (MITF) is the master regulator of melanocyte development, survival, and function...
  8. pmc Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF
    Claudia Wellbrock
    Signal Transduction Team, The Institute of Cancer Research, Cancer Research UK Centre of Cell and Molecular Biology, London, United Kingdom
    PLoS ONE 3:e2734. 2008
    The Microphthalmia-associated transcription factor (MITF) is an important regulator of cell-type specific functions in melanocytic cells...
  9. ncbi The melanocyte-specific isoform of the microphthalmia transcription factor affects the phenotype of human melanoma
    Edgar Selzer
    Department of Radiotherapy and Radiobiology, University Hospital Vienna, 1090 Vienna, Austria
    Cancer Res 62:2098-103. 2002
    The microphthalmia transcription factor MITF plays a pivotal role in the development and differentiation of melanocytes...
  10. pmc Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation
    Claudia Wellbrock
    Signal Transduction Team, Cancer Research UK Centre of Cell and Molecular Biology, The Institute of Cancer Research, London SW3 6JB, England, UK
    J Cell Biol 170:703-8. 2005
    ..Microphthalmia-associated transcription factor (MITF) is an important melanocyte differentiation and survival factor, but its role in melanoma is unclear...
  11. ncbi Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene
    M Tassabehji
    Department of Medical Genetics, St Mary s Hospital, Manchester, UK
    Nat Genet 8:251-5. 1994
    ..We recently mapped a WS2 gene to chromosome 3p12.3-p14.1 and proposed as a candidate gene MITF, the human homologue of the mouse microphthalmia (mi) gene...
  12. pmc Tietz syndrome (hypopigmentation/deafness) caused by mutation of MITF
    S D Smith
    Center for Hereditary Communication Disorders, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    J Med Genet 37:446-8. 2000
    ..This family was reascertained and a missense mutation was found in the basic region of the MITF gene in family members with Tietz syndrome...
  13. ncbi Mitf-D, a newly identified isoform, expressed in the retinal pigment epithelium and monocyte-lineage cells affected by Mitf mutations
    Kazuhisa Takeda
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Biochim Biophys Acta 1574:15-23. 2002
    Microphthalmia-associated transcription factor (Mitf) regulates the differentiation of melanocytes, optic cup-derived retinal pigment epithelium (RPE), and some types of bone marrow-derived cells...
  14. ncbi Sumoylation of MITF and its related family members TFE3 and TFEB
    Arlo J Miller
    Dana Farber Cancer Institute and Children s Hospital, Department of Pediatric Hematology Oncology, Melanoma Program in Medical Oncology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:146-55. 2005
    b>MITF and its related family members TFE3 and TFEB heterodimerize with each other, recognize the same DNA sequences, and are subject to many of the same post-translational modifications...
  15. ncbi c-Met expression is regulated by Mitf in the melanocyte lineage
    Gael G McGill
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    J Biol Chem 281:10365-73. 2006
    ..the mechanism by which HGF up-regulates its receptor, we found that c-Met is a direct transcriptional target of Mitf. This was confirmed with chromatin immunoprecipitation experiments of the human c-Met promoter, as well as by the ..
  16. ncbi Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers
    Ian J Davis
    Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer Cell 9:473-84. 2006
    ..We show that EWS-ATF1 occupies the MITF promoter, mimicking melanocyte-stimulating hormone (MSH) signaling to induce expression of MITF, the melanocytic ..
  17. ncbi Evolutionary sequence comparison of the Mitf gene reveals novel conserved domains
    Jón Hallsteinn Hallsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Pigment Cell Res 20:185-200. 2007
    The microphthalmia-associated transcription factor (MITF) is a member of the MYC family of basic helix-loop-helix leucine zipper transcription factors...
  18. doi Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport
    Christine Chiaverini
    INSERM U895, Biologie et Pathologies des Cellules Mélanocytaires de la Pigmentation Cutanée au Mélanome 28, Avenue de Valombrose, 06107 Nice Cedex 2, France
    J Biol Chem 283:12635-42. 2008
    ..In this study, we show that microphthalmia-associated transcription factor (MITF) silencing induces melanosome gathering around the nucleus and causes the relocalization of Rab27A, Slac2a-Mlph, ..
  19. doi Interleukins 1alpha and 1beta secreted by some melanoma cell lines strongly reduce expression of MITF-M and melanocyte differentiation antigens
    Olga Kholmanskikh
    Ludwig Institute for Cancer Research Ltd, Brussels Branch, and Université Catholique de Louvain, 74 avenue Hippocrate, UCL7459, B1200 Brussels, Belgium
    Int J Cancer 127:1625-36. 2010
    ..receptor exhibit 4- to 10-fold lower levels of mRNA of microphthalmia-associated transcription factor (MITF-M) when treated with interleukin-1beta. This effect is NF-kappaB and JNK-dependent...
  20. pmc The discovery of the microphthalmia locus and its gene, Mitf
    Heinz Arnheiter
    Mammalian Development Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Pigment Cell Melanoma Res 23:729-35. 2010
    The history of the discovery of the microphthalmia locus and its gene, now called Mitf, is a testament to the triumph of serendipity...
  21. doi Hypoxia and MITF control metastatic behaviour in mouse and human melanoma cells
    Y Cheli
    INSERM U895, Centre Méditerranéen de Médecine Moléculaire, Equipe 1, Biology and Pathologies of Melanocytes, Equipe Labellisee par la Ligue Contre le Cancer, Nice, France
    Oncogene 31:2461-70. 2012
    ..In the present report, we show that deletion of microphthalmia-associated transcription factor (MITF), the master gene in melanocyte differentiation, is sufficient to increase the metastatic potential of mouse and ..
  22. doi A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
    Corine Bertolotto
    1 INSERM, U895 équipe 1, Equipe labélisée Ligue contre le cancer, C3M, 06204 Nice, France 2 Université of Nice Sophia Antipolis, UFR Medecine, 06204 Nice, France 3 Centre Hospitalier Universitaire de Nice, Service de Dermatologie, 06204 Nice, France 4
    Nature 480:94-8. 2011
    ..The microphthalmia-associated transcription factor (MITF) has been proposed to act as a melanoma oncogene; it also stimulates the transcription of hypoxia inducible factor (..
  23. pmc Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression
    Jeffrey Adijanto
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 287:20491-503. 2012
    ..Microphthalmia-associated transcription factor (MITF) is a key regulator of RPE differentiation that was also down-regulated in dedifferentiated hfRPE cells...
  24. doi The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells
    Giannicola Genovese
    Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA
    Cell Cycle 11:2206-15. 2012
    ..that inhibits the Wnt/β-catenin pathway in colon cancer cells and Microphthalmia-associated transcription factor (MITF) activity in human mast cells...
  25. doi Prevalence of the E318K MITF germline mutation in Italian melanoma patients: associations with histological subtypes and family cancer history
    P Ghiorzo
    Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy
    Pigment Cell Melanoma Res 26:259-62. 2013
    ..have recently identified a rare germline functional variant in the microphthalmia-associated transcription factor (MITF) (E318K) that predisposes to familial and sporadic melanoma and to renal cell carcinoma (RCC), showing a new link ..
  26. doi Phenotypic characterization of nevus and tumor patterns in MITF E318K mutation carrier melanoma patients
    Richard A Sturm
    Melanogenix Group, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    J Invest Dermatol 134:141-9. 2014
    A germline polymorphism of the microphthalmia transcription factor (MITF) gene encoding a SUMOylation-deficient E318K-mutated protein has recently been described as a medium-penetrance melanoma gene...
  27. doi MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2
    Chonglin Luo
    Department of Translational Immunology, German Cancer Research Center DKFZ, Heidelberg, Germany Electronic address
    Cancer Lett 341:240-7. 2013
    ..We identified microphthalmia-associated transcription factor (MITF) as a direct target of miR-101...
  28. pmc c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi
    M Wu
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 14:301-12. 2000
    ....
  29. pmc Microphthalmia transcription factor as a molecular marker for circulating tumor cell detection in blood of melanoma patients
    Kazuo Koyanagi
    Department of Molecular Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Clin Cancer Res 12:1137-43. 2006
    Microphthalmia transcription factor (Mitf), which is important in melanocyte development and melanoma growth, was assessed using real-time quantitative reverse transcription-PCR assay to investigate its expression as a marker for ..
  30. pmc Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor
    Miguel F Segura
    Department of Pathology, Interdisciplinary Melanoma Cooperative Group, New York University Medical Center New York, NY 10016, USA
    Proc Natl Acad Sci U S A 106:1814-9. 2009
    ..Our data provide a mechanism for invasion and survival in melanoma that could prove applicable to metastasis of other cancers and suggest that miRNA silencing may be a worthwhile therapeutic strategy...
  31. ncbi A gene for Waardenburg syndrome type 2 maps close to the human homologue of the microphthalmia gene at chromosome 3p12-p14.1
    A E Hughes
    Department of Medical Genetics, Belfast City Hospital, UK
    Nat Genet 7:509-12. 1994
    ..05 at zero recombination. Interestingly, the human homologue (MITF) of the mouse microphthalmia gene, a good candidate at the phenotypic level, has recently been mapped to 3p12.3-p14...
  32. pmc Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene
    K Yasumoto
    Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Miyagi, Japan
    Mol Cell Biol 14:8058-70. 1994
    ..of a ubiquitous transcription factor, USF, and a novel factor, microphthalmia-associated transcription factor (MITF), recently cloned as the human homolog of the mouse microphthalmia (mi) gene product...
  33. ncbi The mutational spectrum in Waardenburg syndrome
    M Tassabehji
    Department of Medical Genetics, St Mary s Hospital, Manchester, UK
    Hum Mol Genet 4:2131-7. 1995
    ..such as Waardenburg syndrome (WS) or probable neurocristopathies were screened for mutations in the PAX3 and MITF genes...
  34. ncbi Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes
    K Yasumoto
    Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Aoba ku, Sendai, Japan
    J Biol Chem 272:503-9. 1997
    ..a CATGTG motif, which was shown here to be bound in vitro by microphthalmia-associated transcription factor (MITF)...
  35. ncbi MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
    T J Hemesath
    Division of Pediatric Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 391:298-301. 1998
    ..The pathway represents a new application of the general MAP kinase machinery in transducing a signal between a tissue-specific receptor at the cell surface and a tissue-specific transcription factor in the nucleus...
  36. ncbi Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium
    S Amae
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Miyagi, Japan
    Biochem Biophys Res Commun 247:710-5. 1998
    Mutations at the mouse locus encoding microphthalmia-associated transcription factor (Mitf) affect the development of many cell types, including retinal pigment epithelium (RPE), melanocytes, mast cells, and osteoclasts...
  37. ncbi Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus
    N Fuse
    Department of Molecular Biology and Applied Physiology Saitama Cancer Center, Saitama 362 080, Japan
    J Biochem 126:1043-51. 1999
    Microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix-leucine zipper protein, and plays an important role in the development of various cell types, such as neural-crest-derived melanocytes and optic-cup-derived ..
  38. ncbi Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance
    K Takeda
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Hum Mol Genet 9:125-32. 2000
    b>MITF (microphthalmia-associated transcription factor) is a basic-helix-loop-helix-leucine zipper (bHLHZip) factor which regulates expression of tyrosinase and other melanocytic genes via a CATGTG promoter sequence, and is involved in ..
  39. ncbi Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9
    W Xu
    Roy M and Phyllis Gough Huffington Center on Aging, Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza M320 and VAMC, Houston, Texas, 77030, USA
    Exp Cell Res 255:135-43. 2000
    The basic helix-loop-helix/leucine zipper (bHLH/ZIP) microphthalmia-associated transcription factor (MITF) regulates transcription of genes encoding enzymes essential for melanin biosynthesis in melanocytes and retinal pigmented ..
  40. ncbi Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters
    T Udono
    Department of Molecular Biology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi, Japan
    Biochim Biophys Acta 1491:205-19. 2000
    Microphthalmia-associated transcription factor (MITF) affects the development of many types of cells, including melanocytes and retinal pigment epithelium (RPE)...
  41. ncbi Microphthalmia-associated transcription factor (MITF): multiplicity in structure, function, and regulation
    S Shibahara
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    J Investig Dermatol Symp Proc 6:99-104. 2001
    Microphthalmia-associated transcription factor (MITF) regulates the differentiation and development of melanocytes and retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme ..
  42. ncbi Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling
    Kim C Mansky
    Department of Molecular Genetics and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 277:11077-83. 2002
    ..The microphthalmia transcription factor (MITF) is required for terminal differentiation of osteoclasts...
  43. pmc Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling
    Ken ichi Yasumoto
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    EMBO J 21:2703-14. 2002
    ..between the basic helix-loop-helix and leucine-zipper region of microphthalmia-associated transcription factor (MITF) and LEF-1...
  44. ncbi Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1
    Hideo Saito
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    J Biol Chem 277:28787-94. 2002
    ..is associated with heterozygous mutations in the gene encoding microphthalmia-associated transcription factor (MITF) and characterized by deafness and hypopigmentation due to lack of melanocytes in the inner ear and skin...
  45. ncbi Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
    Gael G McGill
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 109:707-18. 2002
    Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken...
  46. pmc Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor
    Hans R Widlund
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Dana 630, 44 Binney Street, Boston, MA 02115, USA
    J Cell Biol 158:1079-87. 2002
    The transcription factor Microphthalmia-associated transcription factor (MITF) is a lineage-determination factor, which modulates melanocyte differentiation and pigmentation...
  47. pmc MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma
    Jinyan Du
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, Boston, USA
    Am J Pathol 163:333-43. 2003
    The clinically important melanoma diagnostic antibodies HMB-45, melan-A, and MITF (D5) recognize gene products of the melanocyte-lineage genes SILV/PMEL17/GP100, MLANA/MART1, and MITF, respectively...
  48. ncbi A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes
    Wade E Huber
    Division of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:45224-30. 2003
    ..of melanocytes via activation of melanocyte-restricted microphthalmia-associated transcription factor (M-MITF) expression...
  49. ncbi STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression
    Akiko Joo
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Oncogene 23:726-34. 2004
    ..We found that the microphthalmia-associated transcription factor (MITF), an essential transcription factor for melanocyte development and pigmentation, induces anchorage-independent ..
  50. ncbi Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma
    Arlo J Miller
    Dana Farber Cancer Institute and Children s Hospital, Department of Pediatric Hematology Oncology, Boston, Massachusetts, USA
    Cancer Res 64:509-16. 2004
    ..Similarly, the melanocytic markers MLANA/MART1 and MITF also have been shown to lose relative expression during melanoma progression...
  51. ncbi Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
    Jinyan Du
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Boston Children s Hospital, Boston, MA 02115, USA
    Cancer Cell 6:565-76. 2004
    ..expression, CDK2 exhibits tissue-specific regulation by the essential melanocyte lineage transcription factor MITF. In addition, functional studies revealed this regulation to be critical for maintaining CDK2 kinase activity and ..
  52. pmc MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A
    Amy E Loercher
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 168:35-40. 2005
    ..Here, we show that the master melanocyte differentiation factor, microphthalmia transcription factor (MITF), regulates cell cycle exit by activating the cell cycle inhibitor INK4A, a tumor suppressor that frequently is ..
  53. ncbi Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform
    Christine L Hershey
    Division of Pediatric Hematology Oncology and Melanoma Program in Medical Oncology, Dana Farber Cancer Institute and Children s Hospital, Harvard Medical School, 44 Binney Street, Dana 630, Boston, MA 02115, USA
    Gene 347:73-82. 2005
    ..Waardenburg Syndrome Type 2 is caused by mutations in the human Microphthalmia-associated transcription factor (MITF) gene...
  54. ncbi Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 OTL, UK
    Nature 433:764-9. 2005
    ..The microphthalmia-associated transcription factor Mitf has a crucial but poorly defined role in melanoblast and melanocyte survival and in differentiation...
  55. pmc Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells
    Roser Busca
    INSERM U597, Biologie et physiopathologie des cellules mélanocytaires, Faculty of Medicine, 06107 Nice Cedex 2, France
    J Cell Biol 170:49-59. 2005
    ..we report that the melanocyte-specific transcription factor, microphthalmia-associated transcription factor (MITF), binds to the Hif1a promoter and strongly stimulates its transcriptional activity...
  56. ncbi Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
    Levi A Garraway
    Department of Medical Oncology, and Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 436:117-22. 2005
    ..maps with gene expression signatures derived from NCI60 cell lines, we identified the melanocyte master regulator MITF (microphthalmia-associated transcription factor) as the target of a novel melanoma amplification...
  57. pmc Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner
    Hideki Murakami
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Pigment Cell Res 18:265-77. 2005
    The microphthalmia transcription factor MITF plays important roles in several cell lineages including retinal and neural crest-derived pigment cells...
  58. pmc The cleavage of microphthalmia-associated transcription factor, MITF, by caspases plays an essential role in melanocyte and melanoma cell apoptosis
    Lionel Larribere
    INSERM U597, Biologie et Pathologie des cellules mélanocytaires de la pigmentation cutanée aux mélanomes, Ligue Nationale Contre le Cancer, Equipe labellisée 2001, 06107 Nice Cedex 2, France
    Genes Dev 19:1980-5. 2005
    Microphthalmia-associated transcription factor (MITF) M-form is a melanocyte-specific transcription factor that plays a key role in melanocyte development, survival, and differentiation...
  59. ncbi [Mutation screening of MITF gene in patients with Waardenburg syndrome type 2]
    Jing Chen
    Institute of Otolaryngology, Chinese PLA General Hospital, Beijing 100853, China E mail
    Yi Chuan 30:433-8. 2008
    ..MITF (microphthalmia associated transcription factor)is a basic-helix-loop-helix-luecine zipper (bHLHZip) factor which regulates expression of ..
  60. doi Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas
    Jasmin N Dynek
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Res 68:3124-32. 2008
    ..Herein, we show that the lineage survival oncogene microphthalmia-associated transcription factor (MITF) is a critical regulator of ML-IAP transcription in melanoma cells...
  61. doi Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells
    Jane Goodall
    Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, United Kingdom
    Cancer Res 68:7788-94. 2008
    ..In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) controls survival, differentiation, proliferation, and migration/metastasis...
  62. pmc MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1
    Feng Liu
    Department of Medicine, Chao Family Comprehensive Cancer Center, Irvine School of Medicine, University of California, Orange, California 92868, USA
    J Invest Dermatol 129:422-31. 2009
    Microphthalmia-associated transcription factor (MiTF) is a key transcription factor for melanocyte lineage survival. Most previous work on this gene has been focused on its role in development...
  63. doi Pigmentation-related genes and their implication in malignant melanoma susceptibility
    Lara P Fernandez
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid E 28029, Spain
    Exp Dermatol 18:634-42. 2009
    ..that had been mainly associated with congenital pigmentation syndromes (ADTB3A, ATRN, CHS1, EDNRB, HPS, KIT, MGRN1, MITF, MLANA, MYO5A, MYO7A, OA1, OCA2, PAX3 and SOX10) were selected...
  64. pmc Frequent mutations in the MITF pathway in melanoma
    Julia C Cronin
    National Human Genome Research Institute, Bethesda, MD, USA
    Pigment Cell Melanoma Res 22:435-44. 2009
    Microphthalmia-associated transcription factor (MITF) is involved in melanocyte cell development, pigmentation and neoplasia...
  65. doi Transcriptional regulation in melanoma
    Devarati Mitra
    Biology and Biomedical Sciences Program, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Hematol Oncol Clin North Am 23:447-65, viii. 2009
    ..networks of transcriptional activation and repression is microphthalmia-associated transcription factor (MITF), a melanocyte lineage marker that increases pigment production and exhibits diverse effects on cell survival, ..
  66. pmc Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma
    B Keenen
    Department of Biochemistry and Cancer Biology, University of Toledo College of Medicine, Toledo, OH 43614, USA
    Oncogene 29:81-92. 2010
    The microphthalmia-associated transcription factor (MITF) promotes melanocyte differentiation and cell-cycle arrest. Paradoxically, MITF also promotes melanoma survival and proliferation, acting like a lineage survival oncogene...
  67. pmc A genomic screen identifies TYRO3 as a MITF regulator in melanoma
    Shoutian Zhu
    The Skaggs Institute of Chemical Biology and The Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:17025-30. 2009
    ..Microphthalmia-associated transcription factor (MITF) is a master gene regulating melanocyte development and functions as a "lineage addiction" oncogene in malignant ..
  68. doi ERK-regulated differential expression of the Mitf 6a/b splicing isoforms in melanoma
    Aline Primot
    CNRS UMR6061, RTO Team Rennes 1 University, Rennes, France
    Pigment Cell Melanoma Res 23:93-102. 2010
    The master regulator of the melanocyte lineage Mitf is intimately involved in development as well as melanoma, controlling cell survival, differentiation, proliferation and metastasis/migration...
  69. doi SWI/SNF chromatin remodeling complex is critical for the expression of microphthalmia-associated transcription factor in melanoma cells
    Jiri Vachtenheim
    Laboratory of Molecular Biology, University Hospital, Charles University, Prague, Czech Republic
    Biochem Biophys Res Commun 392:454-9. 2010
    The microphthalmia-associated transcription factor (MITF) is required for melanocyte development, maintenance of the melanocyte-specific transcription, and survival of melanoma cells...
  70. doi Review and update of mutations causing Waardenburg syndrome
    Veronique Pingault
    Inserm Unite U955, Département de génétique, Laboratoire de Biochimie et Génétique, Hopital Henri Mondor, Creteil, France
    Hum Mutat 31:391-406. 2010
    ..Six genes are involved in this syndrome: PAX3 (encoding the paired box 3 transcription factor), MITF (microphthalmia-associated transcription factor), EDN3 (endothelin 3), EDNRB (endothelin receptor type B), SOX10 (..
  71. pmc Mitf-Mdel, a novel melanocyte/melanoma-specific isoform of microphthalmia-associated transcription factor-M, as a candidate biomarker for melanoma
    Yixiang Wang
    Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36604, USA
    BMC Med 8:14. 2010
    ..Thus, identification of new melanocyte/melanoma antigens that serve as potential novel candidate biomarkers in melanoma is an important area for investigation...
  72. doi "Transcription physiology" of pigment formation in melanocytes: central role of MITF
    Jiri Vachtenheim
    University Hospital, Prague, Czech Republic
    Exp Dermatol 19:617-27. 2010
    ..The genes for melanin synthesis and deposition are coordinately expressed in melanocytes. The transcription factor MITF, which has been reported to activate more than 25 genes in pigment cells, has emerged as an essential regulator not ..
  73. pmc miR-148 regulates Mitf in melanoma cells
    Benedikta S Haflidadóttir
    Department of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    PLoS ONE 5:e11574. 2010
    The Microphthalmia associated transcription factor (Mitf) is an important regulator in melanocyte development and has been shown to be involved in melanoma progression...
  74. doi PAX3 knockdown in metastatic melanoma cell lines does not reduce MITF expression
    Shujie He
    aDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin bAuckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand
    Melanoma Res 21:24-34. 2011
    PAX3 and MITF are important transcriptional activators in the melanocyte lineage and PAX3 is thought to control MITF expression during normal melanocyte differentiation...
  75. pmc A role for ATF2 in regulating MITF and melanoma development
    Meera Shah
    Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS Genet 6:e1001258. 2010
    ..Gene expression profiling identified higher MITF expression in primary melanocytes expressing transcriptionally inactive ATF2...
  76. pmc Inverse expression states of the BRN2 and MITF transcription factors in melanoma spheres and tumour xenografts regulate the NOTCH pathway
    A E Thurber
    Institute for Molecular Bioscience, Melanogenix Group, The University of Queensland, Brisbane, Queensland, Australia
    Oncogene 30:3036-48. 2011
    ..cells within the melanoma spheres and mouse xenografts each displayed a high level of reciprocal BRN2 or MITF expression, which matched more closely the pattern seen in human melanoma tumours in situ, rather than the ..
  77. pmc In melanoma, beta-catenin is a suppressor of invasion
    I Arozarena
    Molecular Cancer Studies, Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, UK
    Oncogene 30:4531-43. 2011
    ..We demonstrate that this opposing role of nuclear beta-catenin in melanoma is mediated through MITF, a melanoma-specific protein that defines the lineage background of this cancer type...
  78. doi GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells
    Delphine Javelaud
    Institut Curie, Centre de Recherche, Orsay, France
    Pigment Cell Melanoma Res 24:932-43. 2011
    ..correlated with that of the melanocyte-specific transcription factor M-microphthalmia transcription factor (M-MITF) and associated transcriptional program...
  79. doi Regulation of MITF stability by the USP13 deubiquitinase
    Xiansi Zhao
    Cutaneous Biology Research Center and Melanoma Program, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Nat Commun 2:414. 2011
    The microphthalmia-associated transcription factor (MITF) is essential for melanocyte development. Mutation-induced MAPK pathway activation is common in melanoma and induces MITF phosphorylation, ubiquitination, and proteolysis...
  80. pmc Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF
    Erez Feige
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:E924-33. 2011
    Microphthalmia-associated transcription factor (MITF) regulates normal melanocyte development and is also a lineage-selective oncogene implicated in melanoma and clear-cell sarcoma (i.e., melanoma of soft parts)...
  81. pmc A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
    Satoru Yokoyama
    Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Massachusetts 02114, USA
    Nature 480:99-103. 2011
    ..E318K; rs149617956) in the melanoma-lineage-specific oncogene microphthalmia-associated transcription factor (MITF)...
  82. doi Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF
    Silvia I Anghel
    Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, Geneva, Switzerland
    Pigment Cell Melanoma Res 25:482-7. 2012
    ..We demonstrate that BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype...
  83. pmc Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2
    Dongsheng Yan
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
    PLoS ONE 7:e40967. 2012
    ..Using bioinformatics, we identified three potential targets of miR-182, namely MITF, BCL2 and cyclin D2...
  84. pmc MITF-independent pro-survival role of BRG1-containing SWI/SNF complex in melanoma cells
    Lubica Ondrusová
    Laboratory of Transcription and Cell Signaling, Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    PLoS ONE 8:e54110. 2013
    ..The central role in the melanoma transcriptional network has the transcription factor MITF (microphthalmia-associated transcription factor)...
  85. pmc Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF
    Rizwan Haq
    Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Cancer Cell 23:302-15. 2013
    ..We further show that a target of BRAF, the melanocyte lineage factor MITF, directly regulates the expression of PGC1α...
  86. pmc MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function
    Christine Grill
    Department of Biochemistry and Molecular Biology, Biomedical Center, Faculty of Medicine, University of Iceland, Vatnsmyrarvegi 16, 101 Reykjavik, Iceland
    Hum Mol Genet 22:4357-67. 2013
    The basic-helix-loop-helix-leucine zipper (bHLHZip) protein MITF (microphthalmia-associated transcription factor) is a master regulator of melanocyte development...
  87. pmc Gene expression profiling identifies microphthalmia-associated transcription factor (MITF) and Dickkopf-1 (DKK1) as regulators of microenvironment-driven alterations in melanoma phenotype
    Mariusz L Hartman
    Department of Molecular Biology of Cancer, Medical University of Lodz, Lodz, Poland
    PLoS ONE 9:e95157. 2014
    ..We have previously demonstrated that the morphological and functional phenotypes of melanoma can be dynamically altered upon external stimuli...
  88. pmc Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression
    G Denecker
    1 Unit of Molecular and Cellular Oncology, Inflammation Research Center, VIB, 9052 Ghent, Belgium 2 Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium
    Cell Death Differ 21:1250-61. 2014
    ..Zeb2 in the melanocyte lineage results in a downregulation of the Microphthalmia-associated transcription factor (Mitf) and melanocyte differentiation markers concomitant with an upregulation of Zeb1...
  89. pmc A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors
    David J Konieczkowski
    Authors Affiliations Broad Institute of Harvard and MIT, Cambridge Department of Medical Oncology, Dana Farber Cancer Institute Divisions of
    Cancer Discov 4:816-27. 2014
    ..cell lines and patient biopsies showed high expression and activity of the melanocytic lineage transcription factor MITF, intrinsically resistant cell lines and biopsies displayed low MITF expression but higher levels of NF-κB ..
  90. pmc MicroRNA-218 inhibits melanogenesis by directly suppressing microphthalmia-associated transcription factor expression
    Jia Guo
    School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong, P R China
    RNA Biol 11:732-41. 2014
    The microphthalmia-associated transcription factor (MITF) is a pivotal regulator of melanogenic enzymes for melanogenesis, and its expression is modulated by many transcriptional factors at the transcriptional level or post-..
  91. ncbi Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene
    N Fuse
    Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 219:702-7. 1996
    Microphthalmia-associated transcription factor (MITF), the human homolog of the mouse microphthalmia gene product, regulates melanocyte-specific transcription of the tyrosinase gene that codes for an essential enzyme in melanin ..
  92. pmc Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes
    C Bertolotto
    Institut National de la Sante et de la Recherche Medicale U385, Biologie et Physiopathologie de la Peau, Faculte de Medecine, Paris, France
    J Cell Biol 142:827-35. 1998
    ..These findings disclose the mechanism by which cAMP stimulates tyrosinase expression and melanogenesis and emphasize the critical role of microphthalmia as signal transducer in cAMP-induced melanogenesis and pigment cell differentiation...
  93. doi Simultaneous suppression of MITF and BRAF V600E enhanced inhibition of melanoma cell proliferation
    Kenji Kido
    Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku ku, Tokyo
    Cancer Sci 100:1863-9. 2009
    Microphthalmia-associated transcription factor (MITF) is a master gene regulating differentiation of melanocytes, and a lineage survival oncogene mediating pro-proliferative function in malignant melanoma...
  94. pmc The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia-associated transcription factor (MITF) and other melanogenesis-related proteins in normal and pathological skin, hair follicles and melanocytic nevi
    Song Lu
    Division of Dermatology, Albany Medical College MC 81, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Cutan Pathol 37:26-40. 2010
    ..TRPM1 is transcriptionally regulated by the essential melanocyte transcription factor MITF (microphthalmia-associated transcription factor)...
  95. doi What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis
    Ana Abad
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Ciencia y Tecnologia, UPV EHU, Campus de Bizkaia, Leioa, Spain
    Rev Iberoam Micol 27:155-82. 2010
    ..and related genes, such as a diffusible toxic substance from conidia, gliotoxin (gliP and gliZ), mitogillin (res/mitF/asp f 1), hemolysin (aspHS), festuclavine and fumigaclavine A-C, fumitremorgin A-C, verruculogen, fumagillin, ..
  96. ncbi Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature
    Andrew L Folpe
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Surg Pathol 29:1558-75. 2005
    ..S-100 protein, smooth muscle actins (SMA), desmin, vimentin, HMB45, Melan-A, microphthalmia transcription factor (MiTF), TFE3, CD117, and CD34 was performed. Clinical follow-up information was obtained...
  97. ncbi Microphthalmia transcription factor in the immunohistochemical diagnosis of metastatic melanoma: comparison with four other melanoma markers
    M Miettinen
    Armed Forces Institute of Pathology, Department of Soft Tissue Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 25:205-11. 2001
    ..based on the study of a small number of tumors, it was suggested that microphthalmia transcription factor (MITF) is 100% sensitive in the identification of metastatic melanoma...
  98. ncbi Molecular bases of congenital hypopigmentary disorders in humans and oculocutaneous albinism 1 in Japan
    Y Tomita
    Department of Dermatology, Nagoya University School of Medicine, Japan
    Pigment Cell Res 13:130-4. 2000
    ..factor paired box 3 (PAX3) works at the promoter region of the microphthalmia-associated transcription factor (MITF) gene, and the MITF transcription factor orders the expression of c-kit, which encodes the receptor for stem-cell ..
  99. ncbi Absence of TRP-2 in melanogenic melanocytes of human hair
    Stephane Commo
    L Oréal Recherche Centre de recherche C ZVIAK, Groupe biologie du cheveu, 90 rue du General Roguet, 92583 Clichy Cedex, France
    Pigment Cell Res 17:488-97. 2004
    ..Numerous proteins involved in melanocyte function have been identified including pMel-17, Mitf-M, Sox10, tyrosinase, tyrosinase related proteins-1 (TRP-1) and -2 (TRP-2)...
  100. pmc Expression patterns of MITF during human cutaneous embryogenesis: evidence for bulge epithelial expression and persistence of dermal melanoblasts
    Briana C Gleason
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Cutan Pathol 35:615-22. 2008
    ..The melanocyte master transcriptional regulator, microphthalmia transcription factor (MITF), identifies mature melanocytes as well as melanocyte precursor stem cells that reside in the bulge region of the ..
  101. ncbi Kit(+) melanocytes seem to contribute to melanocyte proliferation after UV exposure as precursor cells
    Y Kawaguchi
    Research Laboratories Menard Cosmetic Co, Nishi ku, Nagoya, Japan
    J Invest Dermatol 116:920-5. 2001
    ..0 and 31.7 cells per mm(2), respectively. Only a few Mitf(+) cells and no TRP-2(+) cells were observed...

Research Grants61

  1. Role of TRPM1 (Melastatin1) in the Biology of Human Melanocytes
    Vijayasaradhi Setaluri; Fiscal Year: 2012
    ..Tissue distribution and promoter regulation by microphthalmia transcription factor (MITF) confirmed TRPM1 as a melanocyte-restricted TRP...
  2. John A D'Orazio; Fiscal Year: 2016
    ..and by investigating the ability of cAMP-responsive transcription factors downstream of Mc1r signaling (namely Mitf and CREB) to bind to and induce transcription of NER enzyme promoters...
  3. Ivana L de la Serna; Fiscal Year: 2014
    ..Microphthalmia Transcription Factor (MITF) is the master regulator of melanocyte differentiation and activates the expression of genes important for melanin ..
  4. ATF2 in melanoma development and progression
    ZE apos EV A RONAI; Fiscal Year: 2012
    ..Initial analysis of melanocytes identified a set of pigmentation genes, including MITF, MC1R, Silver, DCT and TYRP1, whose expression is altered in the absence of functional ATF2...
  5. David E Fisher; Fiscal Year: 2016
    ..This proposal represents a longstanding funded project on the MITF transcription factor, whose master regulatory role in melanocyte development was elucidated largely through this ..
  6. Eva Hernando; Fiscal Year: 2016
    ..miR-183-96-182 cluster promotes migration in vitro and metastasis in vivo in part by controlling the expression of MITF, a master regulator of melanocyte differentiation...
  7. CHARLES KORE KAUFMAN; Fiscal Year: 2015
    ..melanocytes requires the activity of a transcription factor called micropthalmia-associated transcription factor (Mitf)...
  8. Vladimir S Spiegelman; Fiscal Year: 2016
    ..Microphtalmia-associated transcription factor (MITF) is a principal regulator of melanocyte development and a pivotal factor in the survival and growth of malignant ..
  9. ROBERT AARON CORNELL; Fiscal Year: 2014
    ..TFAP2 proteins function redundantly, and in parallel with microphthalmia-associated transcription factor (MITF), a central regulator of melanocyte biology, to activate genes that effect melanocyte differentiation...
  10. Aldehyde dehydrogenase: A novel regulator of melanin biogenesis
    Anand K Ganesan; Fiscal Year: 2013
    ..Preliminary data indicates that Aldhl and AldhQ impact the expression of tyrosinase and MITF in normal melanocytes and melanoma cells...
  11. The Role of Ets1 in Melanocyte Development
    Lidia Kos; Fiscal Year: 2012
    ..Mutations in the transcription factors Pax3, Sox10, and Mitf result in hypopigmentation phenotypes in mice and humans...
  12. Is Mitf the Missing Puzzle Linking NFATc1 to Osteoclastogenesis
    Yi Ling Lin; Fiscal Year: 2010
    ..Among these, Mitf is unique in its tissue-specific effects restricted to melanocytes, mast cells and osteoclasts...
  13. Repression by C SKI and Melanoma Progression
    Larry Donehower; Fiscal Year: 2010
    ..SKI is also a potent activator of the Wnt signaling pathway, targeting MITF and NrCAM, two genes involved in survival, migration and invasion...
  14. MATTHEW WAYNE VANBROCKLIN; Fiscal Year: 2016
    ..g., co-expression of HIF1A or MITF)...
  15. Jun S Song; Fiscal Year: 2016
    ..applicable to general TFs, we will develop our tools by focusing on microphthalmia-associated transcription factor (MITF), a key onco-protein frequently amplified in melanoma...
  16. Characterization of neural crest stem cells in human hair follicles.
    Xiaowei Xu; Fiscal Year: 2013
    ..We will study the interaction of Wnt3a, stem cell factor and endothelin-3 with Mitf during this process. We expect that bulge hNCSCs retain the pluripotency and function of embryonic NCSCs...
  17. GENES CONTROLLING PIGMENTATION
    Ruth Halaban; Fiscal Year: 1999
    ..that growth factors activate pre-existing transcription factors which in turn upregulate MITF (microphthalmia associated transcription factor, the human homologue of mouse mi), a recently discovered transcription factor implicated in ..
  18. Role of Microphthalmia/MITF Factor in Eye Development
    Francesca Pignoni; Fiscal Year: 2011
    In the mouse, the Microphthalmia-related Transcription Factor (Mitf) plays a critical role in the development of the retinal pigmented epithelium (RPE) of the eye...
  19. Molecular signatures of melanoma histology and progression: A Population Based A
    Abrar A Qureshi; Fiscal Year: 2013
    ..by two robust signatures: one broadly defined by a cluster of microphthalmia and melanocyte differentiation genes ("MITF" class) and a more heterogeneous group of inflammation, innate immune, and growth-related genes ("IIG" class)...
  20. Coloney Stimulating Factor 1 regulation and role in bone
    KARL LEONARD INSOGNA; Fiscal Year: 2010
    ..proliferation and differentiation, the latter dependent in part on activation of the transcription factor, Mitf. Recent evidence indicates an important role for CSF1 in states of accelerated bone loss including estrogen-..
  21. Carole R Mendelson; Fiscal Year: 2015
    ..and dilation through a transcriptional network involving PRs, ERs, and the novel cervical transcription factor MiTF-CX, and (4) to test the hypothesis that physiological and pathological inflammatory responses in the uterus and ..
  22. CHRISTIE ANNE CIARLO; Fiscal Year: 2015
    ..One category of compounds will be selected for evaluation of antitumor activity in murine xenograft tumors and an mitf:BRAF(V600E);p53 -/- zebrafish model of melanoma developed in our lab...
  23. KIM CARPENTER MANSKY; Fiscal Year: 2016
    ..Further data indicate that these effects are mediated through RANKL-regulated interactions between HDAC7 and the MITF transcription factor...
  24. Clinical Investigation in Tumor Immunotherapy
    Jeffrey A Sosman; Fiscal Year: 2012
    ..Other mutations cooperate with B-RAF including MITF overexpression, CDK4 or CCND1 amplification, PTEN loss, and activation of the Akt pathway...
  25. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2009
    ..it is in its most active form and is able to cooperate with the microphthalmia transcription factor (MITF) to induce melanocytes to differentiate and cease proliferating...
  26. David E Fisher; Fiscal Year: 2016
    ..Project 3 will examine the MITF pathway which antagonizes apoptosis after BRAF(V600E) inhibitor drugs-offering drugable opportunities-and also ..
  27. JAVIER ELBIO IRAZOQUI; Fiscal Year: 2016
    ..The overall objective of this proposal is to elucidate pathways mediated by MITF-TFE (MiT) family transcription factors (TFs) that determine the host IEC response to infection...
  28. Recapitulating developmental pathways to improve iPSC-RPE derivation protocols
    PETER DWAYNE WESTENSKOW; Fiscal Year: 2013
    ..is required for RPE cell-fate maintenance and that ss-catenin can directly regulate the key transcription factors Mitf and Otx2...
  29. Mechanisms Controlling RPE Development
    Sabine Fuhrmann; Fiscal Year: 2013
    ..While some genes crucial for RPE development and function (e.g. Mitf, Otx2) are known, it is unclear how RPE-specific gene expression is initiated and maintained...
  30. SPORE in Skin Cancer
    Thomas S Kupper; Fiscal Year: 2012
    ..Project 3 targets MITF, using the powerful genomic and bioinformatic resources of the Broad Institute to validate associated biomarkers ..
  31. Min Guo; Fiscal Year: 2015
    ..released from MSC, translocates from cytoplasm to the nucleus, and generates Ap4A to activate the transcription of MITF-targeted genes for mast cell activation...
  32. Thomas J Kodadek; Fiscal Year: 2016
    ..Activation of a specific transcriptio factor - MITF - is a critical step for the production of these mediators...
  33. Developmental Checkpoints of Murine Mast Cells
    Koichi Akashi; Fiscal Year: 2009
    ..1, GATA-2 and MITF, and of neutrophils/monocyte-related transcription factor, C/EBPalpha, in mast cell development...
  34. David M Gamm; Fiscal Year: 2014
    ..to pattern the naove OV into the NR and RPE domains by repressing expression of the early RPE-associated gene MITF. Disruption of Vsx2 expression in animal models by various means causes severe defects of the eye and retina, and ..
  35. Molecular Pathway in Retina Regeneration
    Katia Del Rio Tsonis; Fiscal Year: 2004
    ..This study will determine the roles of microphthalmia (Mitf), a rPEC specific transciptional factor, Pax-6 a well known regulator of retina development, as well as the role of ..
  36. Transcriptional Regulation of Osteoclasts by Mitf
    Yi Ling Lin; Fiscal Year: 2005
    ..Mice carrying semidominant Mitf alleles exhibit various degrees of osteopetrosis, indicating Mitf is a promising tool for studying gene regulation ..
  37. Role of TFE3 in Renal Cell Carcinoma
    Christopher Roman; Fiscal Year: 2004
    ..TFE3, a member of the MiT transcription factor family that includes Mitf, the gene mutated in microphthalmia, has been implicated in TGFa, Wnt, and c-kit signaling pathways...
  38. REGULATING MITF'S ACTIVATION OF OSTEOCLAST TARGET GENES
    KIM MANSKY; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Microphthalmia-associated transcription factor (Mitf) and Tfe3 are basic helix-loop-helix leucine zipper transcription factors that are expressed in osteoclasts...
  39. Transcriptional Regulation of Melanocyte Development
    FAITH STRICKLAND; Fiscal Year: 2004
    ..The specific aims of this proposal are to understand the function of the transcription factors Mitf and Pax3 in melanocyte development and to determine how the misexpression of a basic helix-loop-helix transcription ..
  40. 2000 PAN-AMERICAN PIGMENT CELL CONFERENCE
    ESTELA MEDRANO; Fiscal Year: 2000
    ..Speakers and five Scientific Sessions that include: 1) Vertebrate Genetics and Pigmentation, 2) Making Sense of MITF, its multiple roles in Human and Mouse Disorders, 3) keratinocytes, 5) Signal Transduction, UV Irradiation and ..
  41. Epigenetic Chromatin Changes as Melanoma Markers
    Ruth Halaban; Fiscal Year: 2006
    ..Altogether, the results are likely to generate a novel marker(s) that can be used to assess propensity for malignant transformation, tumor progression and/or sensitivity to chemotherapeutic drugs that target chromatin conformation. ..
  42. ChIP-ChIP-Chip: A New Tool To Study RPE Gene Regulation
    Noriko Esumi; Fiscal Year: 2007
    ..Finally, I will begin the process of identifying in vivo direct targets of microphthalmia associated transcription factor (MITF) using the genomic microarray and probes selected by the second ChIP with anti-MITF ..
  43. PROLIFERATION & MALIGNANT TRANSFORMATION OF MELANOCYTES
    Ruth Halaban; Fiscal Year: 2004
    ..Our functional studies may provide a basis for the design of new therapeutical agents for the treatment of patients with metastatic melanomas. ..
  44. Molecular Mechanisms Regulating VMD2 Expression
    Noriko Esumi; Fiscal Year: 2009
    ..to direct RPE-specific expression in transgenic mice and identified microphthalmia-associated transcription factor (MITF) as a potential positive regulator. The goal of this proposal is to extend these findings...
  45. Genetic networks that regulate the mast lineage
    Clifford Takemoto; Fiscal Year: 2009
    ..The microphthalmia-associated transcription factor (Mitf) is essential for the development of mast cells;our laboratory has recently cloned and characterized a novel ..
  46. 2003 Conference Pan-American Society Pigment Cell Resea
    Ruth Halaban; Fiscal Year: 2003
    ..3. To provide partial support to students and junior faculty to attend the meeting. They request funds for the 2003 meeting as well as for the 2 subsequent PASPCR annual meetings in years 2004 and 2006. ..
  47. FUNCTIONAL ANALYSIS OF THE PTEN TUMOR SUPPRESSOR PROTEIN
    Levi Garraway; Fiscal Year: 2009
    ..Based on this data we propose in specific aims 2 and 3: 2. To generate antibody reagents that selectively recognizes unphosphorylated PTEN. 3. To purify and identify proteins in the PTEN associated complex (PAC). ..
  48. Site-specific transgenesis in zebrafish
    JAMES LISTER; Fiscal Year: 2008
    ..These tools will advance the usefulness of this model organism as a model for human development and disease. [unreadable] [unreadable] [unreadable]..
  49. Identify genes causing Kabuki Syndrome
    JEFFREY MILUNSKY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  50. INHIBITION OF OSTEOCLAST ACTIVITY BY OIP-1/HSCAL
    SAKAMURI REDDY; Fiscal Year: 2008
    ..abstract_text> ..
  51. IDENTIFICATION OF GENES INFLUENCING DYSLEXIA
    Shelley Smith; Fiscal Year: 2001
    ..Linkage and association analysis will be used to verify that a candidate gene effects reading disability in the 175 nuclear families. ..
  52. Mitochondrial translocation of p53 and its interaction with manganese superoxide
    Yunfeng Zhao; Fiscal Year: 2008
    ..Overall, these studies will help to understand the apoptotic mechanisms during tumorigenesis, leading to a better design of apoptosis-aimed cancer prevention. [unreadable] [unreadable] [unreadable] [unreadable]..
  53. TAILORING ANTICANCER THERAPY TO LOSS OF P53
    David Fisher; Fiscal Year: 2003
    ..abstract_text> ..
  54. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  55. ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONS
    Janee Gelineau van Waes; Fiscal Year: 2003
    ..abstract_text> ..
  56. MENTORED ORIENTED RESEARCH CAREER DEVELOPMENT AWARD
    Jared Gollob; Fiscal Year: 2004
    ....
  57. Mitf-Signal Responsive Transcription in Osteoclasts
    David Fisher; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Mitf is a helix-loop-helix transcription factor whose mutation produces severe osteopetrosis in multiple species...
  58. The MiT Transcription Factor in Pediatric Malignancies
    David Fisher; Fiscal Year: 2008
    ..Another, TFE3, modulates osteoclast development together with Mitf. We recently cloned a recurring translocation in Papillary Renal Cell Carcinoma (PRCC), and identified the MiT ..
  59. An RNA Sensor for Detection of Circulating Tumor Cells
    Gary Clawson; Fiscal Year: 2008
    ..abstract_text> ..
  60. Analysis of transcription in lens using tiled microarrays (ChIP on chip)
    Ales Cvekl; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  61. Identify Waardenburg syndrome type 2 loci in man
    JEFFREY MILUNSKY; Fiscal Year: 2005
    ..The research project is to identify additional Waardenburg Syndrome type 2 (WS2) loci in man...