MMP12

Summary

Gene Symbol: MMP12
Description: matrix metallopeptidase 12
Alias: HME, MME, MMP-12, macrophage metalloelastase, matrix metallopeptidase 12 (macrophage elastase), matrix metalloproteinase 12 (macrophage elastase)
Species: human

Top Publications

  1. ncbi Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Lab Invest 81:1119-31. 2001
  2. ncbi The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function
    Ladina Joos
    University of British Columbia McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Hum Mol Genet 11:569-76. 2002
  3. doi Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population
    Shin Yup Lee
    Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
    Respiration 80:133-8. 2010
  4. pmc Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis
    Penelope A Bradbury
    Medical Oncology and Hematology, Biostatistics, Princess Margaret Hospital and Department of Medicine, Dalla Lama School of Public Health and University of Toronto, Ontario, Canada
    Carcinogenesis 30:793-8. 2009
  5. ncbi MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan
    C H Wang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Int J Tuberc Lung Dis 14:627-34. 2010
  6. pmc Genetic variation in the matrix metalloproteinase genes and diabetic nephropathy in type 1 diabetes
    Masahiko Kure
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA, USA
    Mol Genet Metab 103:60-5. 2011
  7. ncbi Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII
    O Hiller
    Department of Biochemistry, Faculty of Chemistry, University of Bielefeld, 33615 Bielefeld, Germany
    J Biol Chem 275:33008-13. 2000
  8. ncbi Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure
    R Lang
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Mol Biol 312:731-42. 2001
  9. ncbi Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer
    Li Su
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 27:1024-9. 2006
  10. pmc Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice
    Francesca Margheri
    Department of Experimental Pathology and Oncology, University of Florence, 50134 Florence, Italy
    Neoplasia 11:1106-15. 2009

Research Grants

  1. Macrophage Elastase in Host Defense
    Steven Shapiro; Fiscal Year: 2005
  2. TYPE IV SECRETION &SIGNAL TRANSDUCTION IN EHRLICHIOSIS
    Yasuko Rikihisa; Fiscal Year: 2013
  3. Immunity to Ehrlichial Infections
    Nagaraja Ramavadhani Thirumalapura; Fiscal Year: 2013
  4. Protective Glycopeptide Immunodeterminants of Ehrlichia chaffeensis
    Jere W McBride; Fiscal Year: 2010
  5. Farrah Kheradmand; Fiscal Year: 2016
  6. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2010
  7. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
  8. Landscape Ecology and Mapping of Ehrlichial Pathogens
    MICHAEL WIMBERLY; Fiscal Year: 2006
  9. Hereditary Multiple Exostosis Syndrome: Pathogenesis and Treatment
    MAURIZIO contact PACIFICI; Fiscal Year: 2010
  10. Transmission of Ehrlichia chaffeensis by Adult Ticks
    ROGER STICH; Fiscal Year: 2006

Detail Information

Publications286 found, 100 shown here

  1. ncbi Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects
    A Churg
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Lab Invest 81:1119-31. 2001
    ..also prevented the silica-induced acute inflammatory response in mice with knocked out genes for macrophage metalloelastase (MME -/-), mice that develop inflammation, but not connective tissue breakdown, and the pattern of ..
  2. ncbi The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function
    Ladina Joos
    University of British Columbia McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Hum Mol Genet 11:569-76. 2002
    ..MMP1 (interstitial collagenase), MMP9 (gelatinase B) and MMP12 (macrophage elastase) are thought to be important in the development of emphysema...
  3. doi Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population
    Shin Yup Lee
    Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
    Respiration 80:133-8. 2010
    ..Although a few studies have been conducted to evaluate the association of polymorphisms in matrix metalloproteinase (MMP) genes with chronic obstructive pulmonary disease (COPD), the results have been inconsistent...
  4. pmc Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis
    Penelope A Bradbury
    Medical Oncology and Hematology, Biostatistics, Princess Margaret Hospital and Department of Medicine, Dalla Lama School of Public Health and University of Toronto, Ontario, Canada
    Carcinogenesis 30:793-8. 2009
    ..total of 313 EA cases and 455 age and gender frequency-matched controls were genotyped for MMP1 1G/2G, MMP3 6A/5A, MMP12 -82A/G and MMP12 1082A/G...
  5. ncbi MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan
    C H Wang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Int J Tuberc Lung Dis 14:627-34. 2010
    ..Several matrix metalloproteinase (MMP) polymorphisms favouring the development of lung fibrosis after pulmonary tuberculosis (TB) have been described...
  6. pmc Genetic variation in the matrix metalloproteinase genes and diabetic nephropathy in type 1 diabetes
    Masahiko Kure
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA, USA
    Mol Genet Metab 103:60-5. 2011
    ..51; 95% CI=0.37-0.71, P=6.2×10(-5)). Taken together, our study suggests that genetic variations within the MMP-3/MMP-12 locus influence susceptibility of DN in type 1 diabetes...
  7. ncbi Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII
    O Hiller
    Department of Biochemistry, Faculty of Chemistry, University of Bielefeld, 33615 Bielefeld, Germany
    J Biol Chem 275:33008-13. 2000
    ..Consequently, degradation of these proteins may be important in inflammation, atherosclerosis, and angiogenesis, all of which are known to be influenced by MMP activity...
  8. ncbi Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure
    R Lang
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Mol Biol 312:731-42. 2001
    ..The MMP-12 structure is an excellent template for the structure-based design of specific inhibitors for emphysema therapy and for the construction of mutants to clarify the role of this MMP...
  9. ncbi Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer
    Li Su
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 27:1024-9. 2006
    ..62-8.20) when compared with the most common 1G-5A-82A-1082A haplotype. In conclusion, the combined MMP genotypes and associated haplotypes may be associated with higher risk of lung cancer, particularly among never smokers and men...
  10. pmc Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice
    Francesca Margheri
    Department of Experimental Pathology and Oncology, University of Florence, 50134 Florence, Italy
    Neoplasia 11:1106-15. 2009
    We have previously shown that endothelial cell matrix metalloprotease 12 (MMP12) and pentraxin 3 (PTX3) overproduction is the main alteration accounting for reduced proneness to angiogenesis in systemic sclerosis (SSc)...
  11. ncbi Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages
    S D Shapiro
    Department of Medicine, Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110
    J Biol Chem 268:23824-9. 1993
    ..J. (1992) J. Biol. Chem. 267, 4664-4671). We now report that there is a human orthologue of murine macrophage metalloelastase that we call human macrophage metalloelastase (HME). The full-length HME cDNA spans 1...
  12. ncbi Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase
    T J Gronski
    Department of Medicine, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 272:12189-94. 1997
    ..These results suggest that HME may be required for macrophages to penetrate basement membranes and remodel injured tissue during inflammation...
  13. ncbi Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor
    H Nar
    Department of Medicinal Chemistry, Boehringer Ingelheim Pharma KG, Biberach, Germany
    J Mol Biol 312:743-51. 2001
    ..The present structure enables us to aid the design of potent and selective inhibitors for MMP-12...
  14. ncbi Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease
    S Molet
    Laboratoire de Pharmacodynamie et de Pharmacologie Moléculaire, INSERM U620, Universite de Rennes 1, 2, avenue du professeur Leon Bernard, 35043, Rennes Cedex, France
    Inflamm Res 54:31-6. 2005
    ..Thus, we analyzed the expression and release of MMP-12 (macrophage metalloelastase) in bronchoalveolar lavage (BAL) and lung tissue from COPD patients and control subjects.
  15. ncbi Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing
    Jungmook Lyu
    Department of Ophthalmology and Visual Science, College of Medicine, Catholic University of Korea, Seoul 137 040, Korea
    J Biol Chem 280:21653-60. 2005
    ..By regulating the proliferation of corneal epithelial cells, Wnt-7a and MMP-12 appear to contribute to corneal wound healing...
  16. ncbi Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer
    Heath B Acuff
    Vanderbilt Ingram Cancer Center and Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    Cancer Res 66:7968-75. 2006
    ..The use of the Hu/Mu ProtIn chip allows us to distinguish tumor- and host-derived proteases and guides the further analysis of the significance of these genes in tumor progression...
  17. ncbi Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12
    Susobhan Sarkar
    Department of Oncology, University of Calgary, Calgary, Alberta, Canada
    Cancer Res 66:11771-80. 2006
    ..These results identify a new factor, MMP-12, in regulating glioma invasiveness through interaction with tenascin-C...
  18. pmc Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD
    Agne Babusyte
    Laboratory of Pulmonology, Institute for Biomedical Research, Kaunas University of Medicine, Eiveniu 4, LT 50009, Kaunas, Lithuania
    Respir Res 8:81. 2007
    ..We aimed to analyse airway inflammatory cell patterns in induced sputum (IS) and bronchoalveolar lavage (BAL) from COPD patients who are active smokers and who have ceased smoking >2 years ago...
  19. pmc Bone marrow stromal cells enhance prostate cancer cell invasion through type I collagen in an MMP-12 dependent manner
    Sanaa M Nabha
    Department of Urology, Wayne State University School of Medicine and The Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA
    Int J Cancer 122:2482-90. 2008
    ..Our data suggest that BMS cells induce MMP-12 expression in prostate cancer cells, which results in invasive cells capable of degradation of type I collagen...
  20. doi Matrix metalloproteinase-12 gene regulation by a PPAR alpha agonist in human monocyte-derived macrophages
    Imen Jguirim Souissi
    Research Laboratory on Atherosclerotic Biological and Genetic Factors, Faculty of Medicine, Monastir TN 5019, Tunisia
    Exp Cell Res 314:3405-14. 2008
    ....
  21. doi Matrix metalloproteinase gene polymorphisms: lack of association with chronic obstructive pulmonary disease in a Brazilian population
    H Schirmer
    Programa de Pós Graduação em Diagnóstico Genético e Molecular, Universidade Luterana do Brasil, Canoas, RS, Brasil
    Genet Mol Res 8:1028-34. 2009
    ..Haplotype analysis also did not reveal differences between COPD patients and controls. We found that MMP polymorphisms had no significant impact on the risk of developing COPD in this Brazilian sample...
  22. pmc MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    ..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups...
  23. doi Overexpression of matrix metalloproteinase-12 (MMP-12) correlates with poor prognosis of hepatocellular carcinoma
    Kevin Tak Pan Ng
    Department of Surgery and Centre for Cancer Research, LKS Faculty of Medicine, The University of Hong Kong, China
    Eur J Cancer 47:2299-305. 2011
    ..Our data demonstrated that MMP-12 mRNA may be a valuable prognostic marker for both overall survival and tumour recurrence of HCC patients after liver resection...
  24. doi Influence of matrix metalloproteinase-12 on fibrinogen level
    Anna Motterle
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Atherosclerosis 220:351-4. 2012
    In vitro studies have shown that matrix metalloproteinase-12 (MMP12) can degrade fibrinogen, a clotting factor whose level predicts risk of advanced atherosclerosis and myocardial infarction...
  25. doi Expression of matrix metalloproteinase-12 is correlated with extracapsular spread of tumor from nodes with metastasis in head and neck squamous cell carcinoma
    Jin Man Kim
    Department of Pathology, Chungnam National University, School of Medicine, Daejeon, Republic of Korea
    Eur Arch Otorhinolaryngol 270:1137-42. 2013
    ..024, 0.011). No relation was found between MMP expression and survival. MMP-12 expressed in the primary tumor is a molecular marker that may be useful for predicting ECS in HNSCC patients with metastatic nodal disease...
  26. ncbi Macrophage metalloelastase, MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology
    C Edelstein
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 274:10019-23. 1999
    In this study we found that macrophage metalloelastase, MMP-12 cleaves, in vitro, apolipoprotein(a) (apo(a)) in the Asn3518-Val3519 bond located in the linker region between kringles IV-4 and IV-5, a bond immediately upstream of the ..
  27. ncbi Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease
    Nicolas Lamblin
    Centre Hospitalier Universitaire de Lille, Lille Cedex, France
    J Am Coll Cardiol 40:43-8. 2002
    ..Our hypothesis was that functional polymorphisms in matrix metalloproteinase (MMP) genes may act as susceptibility factors for the development of coronary aneurysms (CAs)...
  28. ncbi Human bronchial epithelial cells express and secrete MMP-12
    Mark C Lavigne
    Wyeth Research, Cardiovascular and Metabolic Diseases, Cambridge, MA 02140, USA
    Biochem Biophys Res Commun 324:534-46. 2004
    ..These findings indicate that the bronchial epithelium may be an important source of elastolytic activity in COPD and tissue remodeling in chronic asthma...
  29. ncbi Matrix metalloproteinase-12 expression correlates with local recurrence and metastatic disease in non-small cell lung cancer patients
    Hans Stefan Hofmann
    Department of Cardio Thoracic Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 4, 06097 Halle, Germany
    Clin Cancer Res 11:1086-92. 2005
    ..Survival after resection of tumor is especially determined by the occurrence of distant metastasis. Matrix metalloproteinases (MMP) support this metastatic process by degradation of the extracellular matrix...
  30. ncbi [Study on matrix metalloproteinase 1, 9, 12 polymorphisms and susceptibility to chronic obstructive pulmonary disease among Han nationality in northern China]
    Rong Bao Zhang
    Respiratory Medicine Department of Peking University People s Hospital, Beijing 100044, China
    Zhonghua Liu Xing Bing Xue Za Zhi 26:907-10. 2005
    ..To study the association between the functional polymorphism of matrix metalloproteinases (MMPs) and the development of chronic obstructive pulmonary disease (COPD)...
  31. doi Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency
    Christopher J McAloon
    Lung Investigation Unit, University Hospital Birmingham, Birmingham, UK
    Ther Adv Respir Dis 3:23-30. 2009
    ..Matrix metalloproteinases [MMPs] are believed to be important in the pathophysiology of COPD, and may therefore confer susceptibility to this phenotype in patients with AATD...
  32. pmc Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population
    Imran Haq
    School of Molecular Medical Sciences, Institute of Genetics, Queen s Medical Centre, University of Nottingham, UK
    BMC Med Genet 11:7. 2010
    ..Previous genetic studies of MMPs in COPD have had inadequate coverage of the genes, and have reported conflicting associations of both single nucleotide polymorphisms (SNPs) and SNP haplotypes, plausibly due to under-powered studies...
  33. ncbi Genetic analysis of MMP gene polymorphisms in patients with Kawasaki disease
    Kazuyuki Ikeda
    Department of Pediatrics, Kyushu University, Fukuoka 812 8582, Japan
    Pediatr Res 63:182-5. 2008
    ..There was no association between other MMP genes and CAL formation. In conclusion, the genetic evaluation by association study demonstrated that the MMP-13 gene, at least in part, contributed to the development of CALs in KD...
  34. ncbi Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage
    B Zhang
    Human Genetics Research Division, Clinical Neurosciences Research Division, University of Southampton, School of Medicine, UK
    Stroke 32:2198-202. 2001
    ..The possible impact of MMP gene polymorphisms on susceptibility to intracranial aneurysms is still controversial, with conflicting data from different reported studies...
  35. ncbi [Treatment of primary and secondary therapy failure in patients with sleep apnea treated with nasal CPAP]
    H Becker
    Medizinische Poliklinik,
    Pneumologie 45:301-5. 1991
    ..If an increase of room temperature and humidity, nasal cream and small amounts of mint-oil as well as a heat-moisture exchanger (HME) prove inadequate, we use a heated humidifier (Dräger, Aquapor).(ABSTRACT TRUNCATED AT 250 WORDS)
  36. pmc Serologic evidence of human monocytic and granulocytic ehrlichiosis in Israel
    A Keysary
    Israel Institute for Biological Research, Ness Ziona, Israel
    Emerg Infect Dis 5:775-8. 1999
    ..We present the first serologic evidence that the agents of human monocytic ehrlichiosis (HME) and HGE are present in Israel...
  37. ncbi Habitat factors influencing distributions of Anaplasma phagocytophilum and Ehrlichia chaffeensis in the Mississippi Alluvial Valley
    J S Manangan
    Warnell School of Forestry and Natural Resources, University of Georgia, College of Veterinary Medicine, Athens, Georgia, USA
    Vector Borne Zoonotic Dis 7:563-73. 2007
    Human monocytotropic ehrlichiosis (HME), caused by the bacterium Ehrlichia chaffeensis, and human granulocytic anaplasmosis (HGA), caused by the bacterium Anaplasma phagocytophilum, are two emerging tick-borne zoonoses of concern...
  38. ncbi [Unconjugated pteridines and neuromeningeal infections]
    P Chatelet
    Service de Neurologie, CH Saint Philibert, Lomme
    Rev Neurol (Paris) 149:331-5. 1993
    ..M), 22 with viral meningitis (VM), 17 with bacterial meningitis (BM), 9 with herpetic meningoencephalitis (HME), 2 with tuberculous meningoencephalitis (TME) and 36 with peripheral systemic infections (PI)...
  39. ncbi Association of the neutral endopeptidase (MME) gene with anxiety
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Psychiatr Genet 10:91-4. 2000
    ..major enzymes for enkephalin degradation is neutral endopeptidase [enkephalinase, membrane metalloendopeptidase (MME)]. We identified a dinucleotide polymorphism in the 5' region of the MME gene...
  40. ncbi Characterization of hot-melt extruded drug delivery systems for onychomycosis
    Praveen K Mididoddi
    Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS, USA
    Eur J Pharm Biopharm 66:95-105. 2007
    The objectives of this investigation were to study the physico-chemical properties of hot-melt extruded (HME) films for onychomycosis and to determine the stability of the model antifungal drug incorporated within these films...
  41. pmc Molecular heterogeneity of Ehrlichia chaffeensis isolates determined by sequence analysis of the 28-kilodalton outer membrane protein genes and other regions of the genome
    Chuanmin Cheng
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    Infect Immun 71:187-95. 2003
    Ehrlichia chaffeensis, a tick-transmitted rickettsial agent, is responsible for human monocytic ehrlichiosis (HME). In this study, we genetically mapped 10 isolates obtained from HME patients...
  42. pmc Lymph node hemophagocytosis in rickettsial diseases: a pathogenetic role for CD8 T lymphocytes in human monocytic ehrlichiosis (HME)?
    Kerry L Dierberg
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    BMC Infect Dis 6:121. 2006
    Human monocytic ehrlichiosis (HME) and Rocky Mountain spotted fever (RMSF) are caused by Ehrlichia chaffeensis and Rickettsia rickettsii, respectively...
  43. ncbi The effects of passive humidifier dead space on respiratory variables in paralyzed and spontaneously breathing patients
    R S Campbell
    Department of Surgery, University of Cincinnati, Ohio 45267 0558, USA
    Respir Care 45:306-12. 2000
    ..However, the additional dead space of these devices may adversely affect respiratory function in certain patients. This study evaluates the effects of passive humidifier dead space on respiratory function...
  44. ncbi Lack of hepatocellular CD10 along bile canaliculi is physiologic in early childhood and persistent in Alagille syndrome
    Jane A Byrne
    Division of Gene and Cell Based Therapy, King s College London School of Medicine, London, UK
    Lab Invest 87:1138-48. 2007
    Many tissues, including hepatobiliary cells, express neutral endopeptidase (CD10), encoded by MME. Serum neutral endopeptidase activity (NEA) has been recommended as a marker of cholestasis in adults but not in children with Alagille ..
  45. ncbi [Clinical and pathologic features of malignant myoepithelioma of salivary glands]
    Qiu lin Liao
    Department of Pathology, General Hospital of Guangzhou Military Area, Guangzhou 510010, China
    Zhonghua Bing Li Xue Za Zhi 34:211-4. 2005
    To analyze the clinical features, morphology and biologic behavior of primary malignant myoepithelioma (MME) of salivary glands.
  46. ncbi Epidemiology of human ehrlichiosis and anaplasmosis in the United States, 2001-2002
    Linda J Demma
    Viral and Rickettsial Zoonoses Branch and Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 73:400-9. 2005
    During 2001 through 2002, 1,176 cases of the tick-borne diseases human monocytic ehrlichiosis (HME) and human granulocytic anaplasmosis (HGA) were reported to the Centers for Disease Control and Prevention (CDC) by 32 states through the ..
  47. pmc Diminished hematopoietic activity associated with alterations in innate and adaptive immunity in a mouse model of human monocytic ehrlichiosis
    Katherine C MacNamara
    New York State Department of Health, Wadsworth Center, Albany, New York 12201 2002, USA
    Infect Immun 77:4061-9. 2009
    Human monocytic ehrlichiosis (HME) is a tick-borne disease caused by Ehrlichia chaffeensis...
  48. ncbi Large-scale expression, refolding, and purification of the catalytic domain of human macrophage metalloelastase (MMP-12) in Escherichia coli
    A A Parkar
    Respiratory and RA Disease Group, Aventi Pharmaceuticals, Bridgewater, New Jersey 08807 0800, USA
    Protein Expr Purif 20:152-61. 2000
    We have cloned, overexpressed, and purified the catalytic domain (residues Gly106 to Asn268) of human macrophage metalloelastase (MMP-12) in Escherichia coli...
  49. doi Isolation, characterization and cloning of a cDNA encoding a new antifungal defensin from Phaseolus vulgaris L. seeds
    Patrícia D Games
    Universidade Estadual do Norte Fluminense, Laboratório de Fisiologia e Bioquímica de Microrganismos, Campos dos Goytacazes, 28013 602 RJ, Brazil
    Peptides 29:2090-100. 2008
    ..Pérola) seeds, basically as described by Terras et al. [Terras FRG, Schoofs HME, De Bolle MFC, Van Leuven F, Ress SB, Vanderleyden J, Cammue BPA, Broekaer TWF...
  50. ncbi Devices used to humidify respired gases
    Jörg Rathgeber
    Department of Anaesthesiology and Intensive Care Medicine, Albertinen Hospital, Süntelstrasse 11 A, D 22 457 Hamburg, Germany
    Respir Care Clin N Am 12:165-82. 2006
    ..Even if the reduction in functional efficiency of the HME that is caused by washing off of the coating of hygroscopic substances is disregarded, the presence of medication ..
  51. ncbi Metapopulation models in tick-borne disease transmission modelling
    HOLLY GAFF
    Community and Environmental Health, College of Health Sciences, Old Dominion University, 3133A Health Sciences Building, Norfolk, Virginia 23529, USA
    Adv Exp Med Biol 673:51-65. 2010
    Human monocytic ehrlichiosis (Ehrlichia chaffeensis), or HME, is a tick-transmitted, ricksettisal disease with growing impact in the United States...
  52. pmc The human ehrlichioses in the United States
    J H McQuiston
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 5:635-42. 1999
    The emerging tick-borne zoonoses human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE) are under reported in the United States...
  53. ncbi Seroprevalence of ehrlichiosis, Lyme borreliosis and tick-borne encephalitis infections in children and young adults in Slovenia
    M Cizman
    Department of Infectious Diseases, University Medical Center, Ljubljana, Slovenia
    Wien Klin Wochenschr 112:842-5. 2000
    ..Little is known about the seroprevalence of ehrlichiosis in adults and much less about the same in children...
  54. ncbi Influence of thermal processing on the properties of chlorpheniramine maleate tablets containing an acrylic polymer
    Yucun Zhu
    Division of Pharmaceutics, College of Pharmacy, University of Texas at Austin, Austin, TX, USA
    Pharm Dev Technol 7:481-9. 2002
    ..TEC were prepared by direct compression (DC), high shear hot-melt granulation (HMG), and hot-melt extrusion (HME)...
  55. ncbi Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies
    Hanna Debiec
    INSERM Unit 489, Tenon Hospital AP HP and University of Paris 6, Paris, France
    Lancet 364:1252-9. 2004
    ..We aimed to investigate whether the disease could affect other families, to search for mutations in the metallomembrane endopeptidase (MME) gene for NEP, and to analyse the outcome of the antenatal renal insult.
  56. ncbi Differentiation-induced loss of heparan sulfate in human exostosis derived chondrocytes
    Jacqueline T Hecht
    Department of Pediatrics, University of Texas Houston Medical School, 6431 Fannin St MSB 3 136, Houston, TX 77030, USA
    Differentiation 73:212-21. 2005
    ..next to the growth plate either as an isolated growth abnormality or as part of the Hereditary Multiple Exostosis (HME) syndrome...
  57. doi ESSC-ESF position paper--science-driven scenario for space exploration: report from the European Space Sciences Committee (ESSC)
    Jean Claude Worms
    ESSC ESF, Strasbourg, France
    Astrobiology 9:23-41. 2009
    In 2005 the then ESA Directorate for Human Spaceflight, Microgravity and Exploration (D-HME) commissioned a study from the European Science Foundation's (ESF) European Space Sciences Committee (ESSC) to examine the science aspects of the ..
  58. ncbi Elastin degradation by matrix metalloproteinases. Cleavage site specificity and mechanisms of elastolysis
    R P Mecham
    Department of Cell Biology and Physiology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:18071-6. 1997
    ..used as a substrate to characterize the peptide bond specificities of human (HME) and mouse macrophage elastase (MME) and to compare these enzymes with other mammalian metalloproteinases and serine elastases...
  59. pmc Comparison of Ehrlichia chaffeensis recombinant proteins for serologic diagnosis of human monocytotropic ehrlichiosis
    X J Yu
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    J Clin Microbiol 37:2568-75. 1999
    Diagnosis of human monocytotropic ehrlichiosis (HME) generally depends on serology that detects the antibody response to immunodominant proteins of Ehrlichia chaffeensis...
  60. ncbi The effect of heat and moisture exchanger and gas flow on humidity and temperature in a circle anaesthetic system
    R Poopalalingam
    Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital, Outram Road, Singapore 169608
    Singapore Med J 43:563-5. 2002
    The aim of the study was to measure the humidity and temperature of the inspired gas in a circle absorber system at fresh gas flows of 11/min and 31/min and assess the need of a heat and moisture exchanger (HME).
  61. pmc Experimental infection of dairy calves with Ehrlichia chaffeensis
    Jose R C delos Santos
    Department of Veterinary Preventive Medicine, Ohio State University, Columbus, OH, USA
    J Med Microbiol 56:1660-8. 2007
    Human monocytic ehrlichiosis (HME) is a zoonotic emerging tick-borne disease with clinical signs that range from mild symptoms to multiple organ failure and death...
  62. doi Olfactory dysfunction following herpetic meningoencephalitis
    Basile Nicolas Landis
    Department of Otorhinolaryngology, Smell and Taste Clinic, University of Dresden Medical School, Technische Universitat Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
    J Neurol 257:439-43. 2010
    Herpetic meningoencephalitis (HME) is a rare but often lethal herpes simplex infection. Patients who survive generally retain neurological deficits...
  63. ncbi Evaluation of immunocompetent and immunocompromised mice (Mus musculus) for infection with Ehrlichia chaffeensis and transmission to Amblyomma americanum ticks
    Amanda D Loftis
    Viral and Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Vector Borne Zoonotic Dis 4:323-33. 2004
    Experiments on the natural history of Ehrlichia chaffeensis, the agent of human monocytic ehrlichiosis (HME), would be facilitated by the availability of a laboratory animal model for transmission to vector ticks...
  64. ncbi Difficulties in the fixation of prostheses for voice rehabilitation after laryngectomy
    E J O ten Hallers
    Department of Biomedical Engineering, Faculty of Medical Sciences, University of Groningen, Groningen, The Netherlands
    Acta Otolaryngol 125:804-13. 2005
    ..review the literature on fixation problems with shunt valves, tracheostoma valves and heat and moisture exchange (HME) filters. Tracheo-oesophageal speech without a valve is not considered...
  65. ncbi Hot-melt extrusion for enhanced delivery of drug particles
    Dave A Miller
    College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, USA
    J Pharm Sci 96:361-76. 2007
    ..The aim of this study was to demonstrate a processing technique in which hot-melt extrusion (HME) is utilized to overcome these limitations...
  66. ncbi Human monocytic ehrlichiosis in children
    Gordon E Schutze
    University of Arkansas for Medical Sciences, Arkansas Children s Hospital, Little Rock, AR, USA
    Pediatr Infect Dis J 26:475-9. 2007
    Human monocytic ehrlichiosis (HME) is a tick-borne illness caused by Ehrlichia chaffeensis. Data about disease in children have been largely derived from case reports or small case series.
  67. pmc Persistent infection contributes to heterologous protective immunity against fatal ehrlichiosis
    Nagaraja R Thirumalapura
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Infect Immun 77:5682-9. 2009
    Human monocytotropic ehrlichiosis (HME), an emerging and often life-threatening tick-transmitted disease, is caused by the obligately intracellular bacterium Ehrlichia chaffeensis...
  68. pmc Outcome of diagnostic tests using samples from patients with culture-proven human monocytic ehrlichiosis: implications for surveillance
    J E Childs
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 37:2997-3000. 1999
    ..from various laboratory tests using samples derived from nine culture-proven cases of human monocytic ehrlichiosis (HME) caused by Ehrlichia chaffeensis...
  69. doi Selective ascorbate toxicity in malignant mesothelioma: a redox Trojan mechanism
    Elia Ranzato
    Department of Environment and Life Sciences, DISAV, University of Piemonte Orientale Amedeo Avogadro, Viale T Michel 11, Alessandria, Italy
    Am J Respir Cell Mol Biol 44:108-17. 2011
    We studied the mechanism of ascorbate toxicity in malignant mesothelioma (MMe) cells...
  70. ncbi Novel mutations in the EXT1 gene in two consanguineous families affected with multiple hereditary exostoses (familial osteochondromatosis)
    M Faiyaz-Ul-Haque
    Program in Genetics and Genomic Biology, Department of Genetics, Hospital for Sick Children, Toronto, Canada
    Clin Genet 66:144-51. 2004
    Multiple hereditary exostoses (HME) is an autosomal dominant developmental disorder exhibiting multiple osteocartilaginous bone tumors that generally arise near the ends of growing long bones...
  71. ncbi Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation
    M D Murphey
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Bldg 54, Rm M 133A, Washington, DC 20306, USA
    Radiographics 20:1407-34. 2000
    ..or multiple, the latter being associated with the autosomal dominant syndrome, hereditary multiple exostoses (HME)...
  72. ncbi Ehrlichiosis: making the diagnosis in the acute setting
    Lisa K Prince
    Infectious Disease Department at Walter Reed Army Medical Center, 6900 Georgia Ave, NW, Washington, DC 20307, USA
    South Med J 100:825-8. 2007
    Human monocytic ehrlichiosis (HME) is a tick-borne disease transmitted during the summer months in the mid-Atlantic, southeastern and south-central United States...
  73. doi Malate metabolism in Hoya carnosa mitochondria and its role in photosynthesis during CAM phase III
    Hoang Thi Kim Hong
    Faculty of Agriculture, Saga University, 1 Honjo Machi, Saga 840 8502, Japan
    J Exp Bot 59:1819-27. 2008
    ..high malate dehydrogenase (mMDH) and aspartate amino transferase (mAST), and a significant amount of malic enzyme (mME) activities. H...
  74. ncbi Accumulation of matrilysin (MMP-7) and macrophage metalloelastase (MMP-12) in actinic damage
    U Saarialho-Kere
    Department of Dermatology, Helsinki University Central Hospital, Finland
    J Invest Dermatol 113:664-72. 1999
    ..of two elastolytic matrix metalloproteinases, matrilysin (matrix metalloproteinase-7) and human macrophage metalloelastase (matrix metalloproteinase-12) in solar damage...
  75. ncbi Protective effects of Hibiscus tiliaceus L. methanolic extract to V79 cells against cytotoxicity and genotoxicity induced by hydrogen peroxide and tert-butyl-hydroperoxide
    Renato Moreira Rosa
    Departamento de Biofisica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    Toxicol In Vitro 21:1442-52. 2007
    ..In a previous study of Hibiscus tiliaceus L. methanolic extract (HME) using bacteria and yeast, as test media, it has been shown that HME strongly inhibited the mutagenic action of H(2)..
  76. pmc Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro
    Jayaraj Ravindran
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Biochem Pharmacol 79:1658-66. 2010
    ..When synthetic curcumin (Cur-S) was compared with bisdemethylcurcumin (BDC), hispolon, hispolon methyl ether (HME), dehydroxy hispolon (DH), hydroxy hispolon (HH), methoxy hispolon methyl ether (MHME), and methoxy hispolon (MH), ..
  77. ncbi Mitral annular motion as a surrogate for left ventricular function: correlation with brain natriuretic peptide levels
    Mohamed Fahmy Elnoamany
    Menofiya University, Egypt
    Eur J Echocardiogr 7:187-98. 2006
    ..Brain natriuretic peptide (BNP) levels have been shown to be elevated in patients with symptomatic LV dysfunction (Dys) and correlate to the severity of symptoms and prognosis...
  78. ncbi Human macrophage metalloelastase gene expression in colorectal carcinoma and its clinicopathologic significance
    W Yang
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Cancer 91:1277-83. 2001
    Human macrophage metalloelastase (HME), also referred as matrix metalloproteinase 12, has been shown to convert plasminogen into angiostatin, an essential inhibitor of tumor angiogenesis...
  79. ncbi [Influence of chemotherapy on hematopoietic microenvironment and effect of autologous bone marrow stromal cell infusion on the recovery of hematopoiesis after chemotherapy]
    J Liu
    Department of Hematology, Air General Hospital, Beijing 100036, China
    Zhonghua Xue Ye Xue Za Zhi 22:341-3. 2001
    ..observe the influence of chemotherapy on hematopoietic progenitor cells (HPC) and hematopoietic microenvironment (HME)...
  80. ncbi A novel EXT1 splice site mutation in a kindred with hereditary multiple exostosis and osteoporosis
    Manuel C Lemos
    Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford Center for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 90:5386-92. 2005
    Hereditary multiple exostosis (HME) is an autosomal dominant disorder characterized by the development of benign cartilage-capped tumors at the juxta-epiphyseal regions of long bones. HME is usually caused by mutations of EXT1 or EXT2.
  81. ncbi Hands-free speech after surgical voice rehabilitation with a Provox voice prosthesis: experience with the Provox FreeHands HME tracheostoma valve system
    K J Lorenz
    Department of Otolaryngology, Head and Neck Surgery, German Armed Forces Hospital, Oberer Eselsberg 40, 89081, Ulm, Germany
    Eur Arch Otorhinolaryngol 264:151-7. 2007
    ..We describe a prospective clinical trial evaluating our experience with the Provox FreeHands HME Automatic Tracheostoma Valve system...
  82. doi Novel EXT1 and EXT2 mutations in hereditary multiple exostoses families of Indian origin
    Vanita Vanita
    Centre for Genetic Disorders, Guru Nanak Dev University, Amritsar, India
    Genet Test Mol Biomarkers 13:43-9. 2009
    Hereditary multiple exostosis (HME) is an autosomal dominant bone disorder, characterized by short stature and the presence of multiple benign tumors mainly at the ends of long bones...
  83. doi Observer variation in the echocardiographic measurement of maximum atrial septal excursion: a comparison of M-mode with two-dimensional or transesophageal echocardiography
    Rajeev Garg
    Division of Cardiology, University of Missouri Columbia School of Medicine, Columbia, Missouri, USA
    Echocardiography 26:1122-6. 2009
    ..This study compares inter- and intraobserver variations in the measurement of maximum atrial septal excursion (MASE) obtained using transthoracic M-mode echocardiography (MME) with that obtained using 2DE or TEE.
  84. doi Design and Evaluation of Topical Diclofenac Sodium Gel Using Hot Melt Extrusion Technology as a Continuous Manufacturing Process with Kolliphor® P407
    Jaywant Pawar
    BASF India Ltd, Pharma Solutions, Plot No 12, TTC Area, Thane Belapur Road, Turbhe, Navi Mumbai, 400705, India
    AAPS PharmSciTech . 2017
    ..and evaluate a Kolliphor® P407-based transdermal gel formulation of diclofenac sodium by hot melt extrusion (HME) technology; central composite design was used to optimize the formulation process...
  85. ncbi An efficiency comparison of four heat and moisture exchangers used in the laryngectomized patient
    W Grolman
    Department of ENT and Head and Neck Surgery, Academic Medical Center, University of Amsterdam, The Netherlands
    Laryngoscope 107:814-20. 1997
    ..This study shows that filter material and size influence the HME's moisture output efficiency and airflow resistance considerably...
  86. ncbi The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate
    C McCormick
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    Nat Genet 19:158-61. 1998
    Hereditary multiple exostoses (HME) is an autosomal dominant disorder characterized by the formation of cartilage-capped tumours (exostoses) that develop from the growth plate of endochondral bone...
  87. ncbi Muscle and temporomandibular joint forces associated with chincup loading predicted by numerical modeling
    Laura R Iwasaki
    Department of Growth and Development, UNMC College of Dentistry, University of Nebraska, Lincoln, NE 68583 0755, USA
    Am J Orthod Dentofacial Orthop 124:530-40. 2003
    ..loading of the mandible were consistent with the objectives of minimization of joint loads (MJL) or muscle effort (MME), or both...
  88. ncbi Antinociceptive effect of Melastoma malabathricum ethanolic extract in mice
    M R Sulaiman
    Department of Biomedical Sciences, Faculty of Medicine Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Fitoterapia 75:667-72. 2004
    The antinociceptive effect of the ethanolic extract of Melastoma malabathricum (MME) was investigated using acetic acid-induced abdominal writhing test and hot-plate test in mice. It was demonstrated that the extract (30-300 mg/kg, i.p...
  89. ncbi Heat modulation of tropoelastin, fibrillin-1, and matrix metalloproteinase-12 in human skin in vivo
    Zhou Chen
    Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Institute of Dermatological Science, Seoul National University, Seoul, Korea
    J Invest Dermatol 124:70-8. 2005
    ..Our results suggest that the abnormal production of tropoelastin and fibrillin by heat in human skin and that their degradation by various MMP, such as MMP-12, may contribute to the accumulation of elastotic material in photoaged skin...
  90. pmc Conformational variability of matrix metalloproteinases: beyond a single 3D structure
    Ivano Bertini
    Magnetic Resonance Center Centro di Risonanze Magnetiche, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Italy
    Proc Natl Acad Sci U S A 102:5334-9. 2005
    ..Backbone flexibility may play a role in the difficulties encountered in the design of selective inhibitors, whereas it may be a requisite for substrate binding and broad substrate specificity...
  91. pmc Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms
    Toru Ogata
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Vasc Surg 41:1036-42. 2005
    ..Our hypothesis was that genetic variations in one or more of these genes contribute to greater or lesser activity of these gene products, and thereby contribute to susceptibility for developing AAAs...
  92. ncbi Local cytokine environments drive aneurysm formation in allografted aortas
    Koichi Shimizu
    Cardiovascular Division, Department of Medicine, The Donald W Reynolds Cardiovascular Clinical Research Center, Harvard Medical School, 77 Avenue Louis Pasteur, NRB7, Boston, MA 02115, USA
    Trends Cardiovasc Med 15:142-8. 2005
    ..The new findings establish important regulatory roles for a Th1/Th2 cytokine balance in modulating matrix remodeling, and have important implications for the pathophysiology of abdominal aortic aneurysms as well as atherosclerosis...
  93. ncbi Hereditary multiple exostoses with pseudoaneurysm
    Azmy M Al-Hadidy
    Department of Diagnostic Radiology, Jordan University Hospital, University of Jordan, Amman 11942, Jordan
    Cardiovasc Intervent Radiol 30:537-40. 2007
    A 16-year-old male patient with hereditary multiple exostoses (HME) was found to have a pseudoaneurysm of the left popliteal artery caused by osteochondroma in the lower femur...
  94. doi HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells
    Karen Grigo
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Universitat Duisburg Essen, D 45122 Essen, Germany
    Biol Chem 389:179-87. 2008
    ..effect of HNF4 alpha on cell proliferation, including well-known cancer genes, such as CDKN1A (p21), TGFA, MME (NEP) and ADAMTS1...
  95. doi Shear and extensional rheology of hydroxypropyl cellulose melt using capillary rheometry
    Anant Paradkar
    Department of Pharmaceutics, Bharati Vidyapeeth University, Poona College of Pharmacy, Pune, India
    J Pharm Biomed Anal 49:304-10. 2009
    ..relationships between shear and extensional flows with temperature, processing rate and molecular weight is a useful tool for process design; optimisation and troubleshooting of Hot melt extrusion (HME) of pharmaceutical formulations.
  96. doi The syndrome of Capgras
    Arthur Sinkman
    NYU School of Medicine, New York City, NY, USA
    Psychiatry 71:371-8. 2008
    ..Capgras's original patient, Mme M., had a complex mental illness with various symptoms in addition to the delusion of substitution...
  97. pmc Correction of knee and ankle valgus in hereditary multiple exostoses using the Ilizarov apparatus
    E Ofiram
    Department of Orthopaedic Surgery, Kaplan Medical Center, P O Box 1, Rehovot, 76100, Israel
    J Orthop Traumatol 9:11-5. 2008
    Hereditary multiple exostoses (HME) is a genetic disorder that causes limb deformities due to disturbance at the growth plates.
  98. doi Association of functional polymorphisms in MMPs genes with gastric cardia adenocarcinoma and esophageal squamous cell carcinoma in high incidence region of North China
    Yan Li
    Department of Molecular Biology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China
    Mol Biol Rep 37:197-205. 2010
    ..Our study indicated that these four functional polymorphisms might play roles in developing ESCC and GCA in high incidence region of North China...
  99. doi Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation
    Amanda Cobos-Correa
    1 Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany 2 Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and University of Heidelberg, Heidelberg, Germany
    Nat Chem Biol 5:628-30. 2009
    b>MMP12 is a metalloproteinase implicated in inflammation. To monitor its activity, we synthesized a membrane-targeted reporter (LaRee1) based on Foerster resonance energy transfer (FRET)...
  100. doi Activation of microglia/macrophages expressing phosphorylated S6 ribosomal protein in a case of hemimegalencephaly with progressive calcification and atrophy
    Yutaka Nonoda
    Department of Child Neurology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi cho, Kodaira, Tokyo 187 8551, Japan
    J Neurol Sci 287:52-9. 2009
    A 3-year-old boy with right hemimegalencephaly (HME) showed massive calcification in the subcortical white matter and progressive atrophy of the affected hemisphere...
  101. pmc Comparison of two different types of heat and moisture exchangers in ventilated patients
    Syed Moied Ahmed
    Department of Anaesthesiology and Critical Care, JN Medical College, Aligarh Muslim University, Aligarh, India
    J Emerg Trauma Shock 2:164-9. 2009
    Study Objectives: To compare the efficacy of two different types of Heat and Moisture Exchangers (HME filters) in reducing transmission of infection from the patient to ventilator and vice versa and also its cost effectiveness...

Research Grants68

  1. Macrophage Elastase in Host Defense
    Steven Shapiro; Fiscal Year: 2005
    ..If the mutation is lethal or not fully deficient in pulmonary macrophages, then lung-specific transgenic mice will be used to inducibly express DT in lungs of mature mice. ..
  2. TYPE IV SECRETION &SIGNAL TRANSDUCTION IN EHRLICHIOSIS
    Yasuko Rikihisa; Fiscal Year: 2013
    ..potentially fatal infectious diseases human granulocytic anaplasmosis (HGA) and human monocytic ehrlichiosis (HME), respectively...
  3. Immunity to Ehrlichial Infections
    Nagaraja Ramavadhani Thirumalapura; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human monocytotropic ehrlichiosis (HME), caused by the obligately intracellular bacterium Ehrlichia chaffeensis, is an emerging, often life-threatening, tick-transmitted infectious disease in the ..
  4. Protective Glycopeptide Immunodeterminants of Ehrlichia chaffeensis
    Jere W McBride; Fiscal Year: 2010
    ..Human monocytotropic ehrlichiosis (HME) is a life-threatening emerging tick-borne zoonosis caused by the obligately intracellular bacterium, E...
  5. Farrah Kheradmand; Fiscal Year: 2016
    ..protein of 10 kD (IP-10, CXCL10), and strongly up-regulate macrophage elastolytic proteinases, in particular MMP12 and MMP9...
  6. Spatially-explicit mathematical model of human monocytic ehrlichiosis
    HOLLY GAFF; Fiscal Year: 2010
    ..The identified primary vector of HME is the Lone Star tick (Amblyomma americanum), and the primary reservoir host is the white-tailed deer (Odocoileus ..
  7. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..induced by IFN? (MIG, or CXCL9) and strongly up-regulate macrophage elastolytic proteinases, in particular MMP12 and MMP9...
  8. Landscape Ecology and Mapping of Ehrlichial Pathogens
    MICHAEL WIMBERLY; Fiscal Year: 2006
    ..Two of these diseases are human monocytotropic ehrlichiosis (HME), caused by Ehrlichia chaffeensis; and human granulocytic anaplasmosis (HGA) caused by Anaplasma phagocytophilum...
  9. Hereditary Multiple Exostosis Syndrome: Pathogenesis and Treatment
    MAURIZIO contact PACIFICI; Fiscal Year: 2010
    ..Hereditary Multiple Exostosis Syndrome (HME) is a rare autosomal dominant disorder that affects about 1 in 50,000 children and adolescents...
  10. Transmission of Ehrlichia chaffeensis by Adult Ticks
    ROGER STICH; Fiscal Year: 2006
    DESCRIPTION (provided by the applicant): Approaches to the control of human monocytic ehrlichiosis (HME), the most prevalent zoonotic ehrlichial disease reported in the USA to date, rely on better understanding of interactions between ..
  11. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2000
    ..of protective immunity against Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis (HME)...
  12. HUMAN EHRLICHIOSIS SURVEILLANCE AND EPIDEMIOLOGY
    William Davidson; Fiscal Year: 2003
    DESCRIPTION (Adapted from the Applicant's Abstract): Two tick-borne ehrlichioses, human monocytic ehrlichiosis (HME) caused by Ehrlichia chaffeensis and human granulocytic ehrlichiosis (HGE) caused by Ehrlichia equi or a closely related ..
  13. Ehrlichia Glycoprotein Modulation of Macrophage Gene Expression
    Jere McBride; Fiscal Year: 2009
    ..Ehrlichia chaffeensis, an obligate intracellular bacterium, is the agent of human monocytotropic ehrlichiosis (HME), a life-threatening emerging tick-borne zoonosis. During E...
  14. Molecular Determinants of Tumor Progression in A Steatolic Liver Microenvironment
    Harold L Moses; Fiscal Year: 2013
    ..Microarray analysis indicates that the matrix metalloproteinases MMP12 and MMP13 are markedly elevated in the steatotic microenvironment, leading to the hypothesis that tumor cells ..
  15. Pathogenic Role of NK Cells During Infection-Induced Toxic Shock
    Nahed Ismail; Fiscal Year: 2012
    ..Human monocytotropic ehrlichiosis (HME) is a highly prevalent life-threatening tick-borne disease in North America caused by E. chaffeensis...
  16. Pathophysiology of PPARgamma in the lung
    Hong Du; Fiscal Year: 2012
    ..In addition, the expression level of MMP12 increased 55-fold in the dnPPAR( transgenic mice...
  17. CSILLA LIPPERT; Fiscal Year: 2015
    ..and that mast cells, airway smooth muscle cells, and fibroblasts will be labeled by ACPPs that are specific for MMP12, chymase, and ADAM33. ACPPs with fluorescent and/or non-optical (e.g...
  18. Yu Yamaguchi; Fiscal Year: 2016
    ..example, mutations of the gene encoding an enzyme essential for HS synthesis cause Hereditary Multiple Exostosis (HME), which is one of the most common genetic bone disorders in clinical orthopedics...
  19. Matilda Frances Chan; Fiscal Year: 2016
    ..We have found that MMP12 (macrophage metalloelastase) is expressed in injured corneas and has a protective effect on corneal fibrosis during wound repair...
  20. Mehran M Sadeghi; Fiscal Year: 2016
    ..If validated, MMP-12 targeted imaging may identify patients at risk for acute coronary syndromes and aneurysm rupture and help track the effect of novel therapeutic interventions in vascular diseases. ..
  21. Tobias M Hohl; Fiscal Year: 2014
    ..strain to demonstrate that AMs employ distinct conidiacidal mechanisms and implicate matrix metalloprotease 12 (MMP12) in this process...
  22. TICK-BORNE DISEASE PANEL TEST
    Andrew Levin; Fiscal Year: 2000
    ..disease test will be the first commercial kit available to clinical laboratories for serodiagnosis of HGE, HME, Babesia, RMSF and Lyme disease...
  23. Vitamin D Regulation of CD14 in Mammary Epithelial Cells
    KATRINA MARIE SIMMONS; Fiscal Year: 2013
    ..Preliminary data with human mammary epithelial (hTERT-HME) cells demonstrated that vitamin D induces expression and secretion of CD14, a protein that bind bacterial ..
  24. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud A ElSohly; Fiscal Year: 2010
    ..We have, therefore, embarked on the development of a new formulation based on Hot Melt Extension (HME) to deliver THC from a Transmucosal Matrix Patch (TMP)...
  25. DETECTION AND RISK OF EHRLICHIAL DISEASES
    RICHARD FALCO; Fiscal Year: 2000
    ..adapted from applicant's abstract): Human granulocytic ehrlichiosis (HGE) and human monocytic ehrlichiosis (HME) are emerging tick-borne disease in the U.S...
  26. Hereditary Multiple Exostoses: Insights Into Pathogenesis
    Dan Wells; Fiscal Year: 2006
    ..to establish a clinical and research community devoted to understanding and treating Hereditary Multiple Exostosis (HME)...
  27. Neuronal heparan sulfate deficiency and autism
    Yu Yamaguchi; Fiscal Year: 2007
    ..2) Hereditary Multiple Exostosis (HME) is an autosomal dominant bone disorder that is caused by defective HS synthesis due to mutations of the GlcNAc/..
  28. Heparan sulfate-dependent mechanisms of skeletogenesis
    Julianne Huegel; Fiscal Year: 2012
    ..conditions are caused by mutations in HS- related mechanisms, and a case in point is Hereditary Multiple Exostoses (HME) that I am studying as part of my ongoing Ph.D. thesis work...
  29. Maurizio Pacifici; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Hereditary Multiple Exostoses (HME) is an autosomal dominant disorder that affects about 1 in 20,000 children...
  30. Genetic Factors Controlling Effector Function of TGF-beta in COPD and Fibrosis
    Chun Geun Lee; Fiscal Year: 2011
    ..AIM #4. Define the genes that determine whether TGF-b1 induceds a predominantly fibrotic versus emphysematous response in C57BL/6 and Balb/c mice. ..
  31. Gary W Mathern; Fiscal Year: 2016
    ..identified the first de novo somatic mutations in the developing brain in the condition "hemimegalencephaly", (HME) a catastrophic focal epilepsy condition associated with a malformation of cerebral cortical development (MCD)...
  32. Richard D Morgan; Fiscal Year: 2014
    ..Engineered Mme-I-like enzymes also offer the potential for targeted therapeutic use with minimal off target cleavage and toxicity...
  33. Peter B Crino; Fiscal Year: 2016
    ..Several DBM subtypes such as focal cortical dysplasia (FCD), hemimegalencephaly (HME), and ganglioglioma (GG) are associated with enhanced mTOR pathway signaling during brain development...
  34. RCT for Smoking Cessation in 10 Medical Schools
    Judith K Ockene; Fiscal Year: 2013
    ..of teaching the 5As to medical students: 1) traditional medical education (TE), and 2) multi-modal education (MME) that adds two components to TE: a web-based instructional program for students and preceptor training...
  35. Plasma AB as a Surrogate Genetic Marker for LOAD
    Steven G Younkin; Fiscal Year: 2012
    ..series to analyze the variants in conserved regions of major genes in the AB processing pathway (SORL1, APP, IDE, MME, ECE1, PLAU, BACE1, PSEN1, PSEN2, and VR22), and (3) evaluate the functional effects of the susceptibility alleles ..
  36. CARDIAC GROWTH REGULATION
    Kaie Ojamaa; Fiscal Year: 1999
    ..a cis-acting element at -47 bp from the transcription initiation site, designated hemodynamic response element (HME), that is both necessary and sufficient to confer contractile responsiveness in spontaneously contracting ..
  37. Amphiregulin Signaling in Human Breast Cancer
    Stephen P Ethier; Fiscal Year: 2013
    ..AREG activation of EGFR fundamentally alters the biology of HME cells and induces phenotypes expressed by highly aggressive and drug-resistant breast cancer cells...
  38. EXTRACELLULAR MATRIX REPAIR IN PULMONARY EMPHYSEMA
    Steven Shapiro; Fiscal Year: 2002
    ....
  39. Integrated, on-chip RT-MME-PCR for influenza diagnostics; Phase 1 = sample prepar
    Darrell Chandler; Fiscal Year: 2007
    ..be to establish influenza reverse transcriptase, multiplexed, microarray-enhanced polymerase chain reaction (RT-MME-PCR) amplification protocols on the Akonni gel element array platform; integrate the sample preparation and RT-MME-..
  40. Genomic Instability and Senescence in Cancer
    Lynne Elmore; Fiscal Year: 2009
    ..using two well-characterized in vitro models of breast cancer, namely Li Fraumeni human mammary epithelial (HME) cells and MCF-7 human breast cancer cells...
  41. UPTAKE AND ACTIONS OF GENISTEIN IN MAMMARY CANCER MODELS
    Stephen Barnes; Fiscal Year: 1999
    ..in the mammaries of rats exposed to genistein and its glycosidic conjugates, and b) in human mammary epithelial (HME) cells...
  42. CARDIAC GROWTH REGULATION
    Kaie Ojamaa; Fiscal Year: 2002
    ..element at -47 bp of the transcriptional start site of the alpha-MHC gene, designated hemodynamic response element (HME), that is both necessary and sufficient to confer contractile responsiveness to this promoter in cardiac myocytes...
  43. Stephen C Jameson; Fiscal Year: 2016
    ..e. in lymphopenic animals). This proliferative process has been called T-cell homeostatic expansion (HME)...
  44. MENTAL EFFORT EFFECT ON LARGE MUSCLE STRENGTHENING
    Guang Yue; Fiscal Year: 2002
    ..We expect that the strength improvement after training will be: MVC group > HME group > LME group = control group...
  45. METALLOELASTASE INDUCTION FOLLOWING INTEGRIN KNOCKOUT
    David Morris; Fiscal Year: 2005
    ..alpha2-beta6 on the surface of respiratory epithelial cells modulates alveolar macrophage expression of Macrophage Metalloelastase (MME, MMP-12) thereby regulating airway inflammation, and matrix degradation...
  46. ELASTASE SECRETION BY MACROPHAGES
    Richard White; Fiscal Year: 1980
    ....
  47. ALTERED SIGNALING IN TRANSFORMED BREAST EPITHELIAL CELLS
    Stephen Ethier; Fiscal Year: 2004
    ..of PI3 kinase and its downstream signaling pathways mediate the alter phenotypes expressed by transformed HME cells expressing varying levels of erbB-2...
  48. Strategy for Therapy of the Pseudoachondroplasia (PSACH) Phenotype: Understanding
    Jacqueline Hecht; Fiscal Year: 2006
    ..abstract_text> ..
  49. Genetic Studies of Clubfoot (ITEV)
    Jacqueline T Hecht; Fiscal Year: 2010
    ..Identification of high-risk genotypes can lead to the development of prevention programs in selected populations and may suggest gene-based prevention strategies. ..
  50. Ehrlichia chaffeensis protective proteins
    David H Walker; Fiscal Year: 2010
    ..chaffeensis. ..
  51. X-ray diffraction analysis of human adenovirus
    Vijay Reddy; Fiscal Year: 2006
    ..et al. Science 309: 1090-1092, 2005). [unreadable] [unreadable] [unreadable]..
  52. HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSES
    Peter Krause; Fiscal Year: 2001
    ..The density of deer will be estimated in each site. This proposed effort will help define the health burden imposed on people residing in proximity to deer and will contribute to diagnosis and case-management of apparent Lyme disease. ..
  53. Regulation of Recall Responses During Ehrlichiosis
    Gary M Winslow; Fiscal Year: 2010
    Human monocytic ehrlichiosis (HME) is a relatively new tick-borne disease caused by obligate intracellular bacteria of the genus ehrlichia...
  54. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..These efforts are expected to reveal an important role for the p44-multigene family in strategies of adaptive surface variation and avoidance of host immune responses. ..
  55. Oxidant induced gene expression in vitamin E deficient *
    Kishorchandra Gohil; Fiscal Year: 2002
    ..These molecular data may provide the basis for designing more effective protocols for dietary interventions with antioxidants that might ameliorate lung diseases induced by environmental oxidants. ..
  56. "The alveolar epithelium in lung injury and repair"
    Gustavo Matute Bello; Fiscal Year: 2010
    ..In addition, we will investigate the potential treatments that will facilitate the repair of injured lungs. ..
  57. Molecular Mechanisms of HIV-1 DNA Integration
    SAMSON CHOW; Fiscal Year: 2008
    ..abstract_text> ..
  58. ROLES OF EHRLICHIAL OUTER MEMBRANE PROTEIN IN PARASITISM
    Yasuko Rikihisa; Fiscal Year: 2001
    ..Aim 5 addresses hypothesis 3 by examining the effects of immunization with the ehrlichial OMP in a mouse model of human ehrlichiosis. ..
  59. Comparison of Human Ehrlichiosis Agent Genomes
    Yasuko Rikihisa; Fiscal Year: 2010
    ..and macrophages, and causes a potentially fatal emerging infectious disease called Human monocytic ehrlichiosis (HME). The complete E. chaffeensis Arkansas genome sequence was published in 2006...
  60. Microglial interactions with amyloid beta peptide
    Douglas Walker; Fiscal Year: 2003
    ..Overall, the findings from the proposed research could extend our knowledge of the inflammatory events occurring in the AD brain. ..
  61. Ehrilchiacidal Mechanisms In Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2009
    ..Ehrlichia chaffeensis and Anaplasma phagocytophilum cause emerging infectious diseases, human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE), respectively...
  62. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2007
    ..This information will provide a framework for rational design of therapies aimed at modulating immune injury and could foster design of preventative measures aimed at immunization. ..
  63. Antibody mediated intracellular bacterial elimination
    Gary Winslow; Fiscal Year: 2006
    ..the obligate intracellular bacterium Ehrlichia chaffeensis, the etiologic agent of human monocytic ehrlichiosis (HME). Preliminary studies have confirmed the feasibility of the mouse model to study immunity to E...
  64. The FastFasL system in lung injury
    Gustavo Matute Bello; Fiscal Year: 2006
    ..The proposed studies will allow for the acquisition of new techniques and further scientific development of the trainee into an independent investigator. ..
  65. p38 MAP Kinase and Akt Interaction in HUVEC
    Shehla Pervin; Fiscal Year: 2008
    ..This investigation could help us understand the mechanisms by which the mortality rate of male fetus and neonates is higher than female. [unreadable] [unreadable] [unreadable]..