MxA

Summary

Gene Symbol: MxA
Description: MX dynamin like GTPase 1
Alias: IFI-78K, IFI78, MxA, interferon-induced GTP-binding protein Mx1, interferon-induced protein p78, interferon-inducible protein p78, interferon-regulated resistance GTP-binding protein MxA, myxoma resistance protein 1, myxovirus (influenza virus) resistance 1, interferon-inducible protein p78
Species: human

Top Publications

  1. ncbi Interferon-induced Mx proteins in antiviral host defense
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Biochimie 89:812-8. 2007
  2. ncbi SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Germany
    Biochem Biophys Res Commun 331:543-8. 2005
  3. pmc Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle
    J Pavlovic
    Institute for Immunology and Virology, University of Zurich, Switzerland
    J Virol 66:2564-9. 1992
  4. ncbi Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro
    M Hijikata
    Department of Medical Sciences, Toshiba General Hospital, Tokyo, Japan
    Intervirology 44:379-82. 2001
  5. ncbi Hepatitis B virus downregulates the human interferon-inducible MxA promoter through direct interaction of precore/core proteins
    Mario Fernandez
    Fundacion para el Estudio de las Hepatitis Virales, C Guzmán el Bueno 72, 28015 Madrid, Spain
    J Gen Virol 84:2073-82. 2003
  6. ncbi Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR
    S Knapp
    Hepatology Section, Faculty of Medicine, Imperial College of Science, Medicine and Technology at St Mary s Hospital, London, UK
    Genes Immun 4:411-9. 2003
  7. pmc Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome
    Kadir Turan
    University of Marmara, Faculty of Pharmacy, Department of Pharmaceutical Biotechnology, Haydarpasa, Kadikoy, Istanbul 34668, Turkey
    Nucleic Acids Res 32:643-52. 2004
  8. ncbi Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis
    H Torisu
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neurology 62:457-60. 2004
  9. ncbi The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein
    Martin Spiegel
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Clin Virol 30:211-3. 2004
  10. ncbi Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population
    Emi Hamano
    Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, Japan
    Biochem Biophys Res Commun 329:1234-9. 2005

Research Grants

  1. Does Diabetic Hyperglycemia Regulate Atherosclerosis Progression and Regression?
    ROBERT RAFFAI; Fiscal Year: 2013
  2. IFN-a and pDC in HIV infection: impact on T cell development and reconstitution
    Christel H Uittenbogaart; Fiscal Year: 2013
  3. Cheng Kui Qu; Fiscal Year: 2016
  4. Jun Xu; Fiscal Year: 2015
  5. James T Handa; Fiscal Year: 2015
  6. Dongsu Park; Fiscal Year: 2016
  7. Mone Zaidi; Fiscal Year: 2016
  8. Functional Genomics of the Cavernous Malformation Gene
    Murat Gunel; Fiscal Year: 2013
  9. In Vivo Analysis of Oncogenic Kras in Leukemogenesis
    BENJAMIN BRAUN; Fiscal Year: 2009
  10. Kevin M Shannon; Fiscal Year: 2016

Patents

  1. Interferon-induced human protein in pure form, monoclonal antibodies thereto, and test kits containing these antibodies

Detail Information

Publications244 found, 100 shown here

  1. ncbi Interferon-induced Mx proteins in antiviral host defense
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Biochimie 89:812-8. 2007
    ..The human MxA GTPase accumulates in the cytoplasm and is partly associated with a COP-I-positive subcompartment of the ..
  2. ncbi SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, Germany
    Biochem Biophys Res Commun 331:543-8. 2005
    ..Similarly, IL-28A and IL-29 induced mRNA expression of the antiviral proteins 2',5'-OAS and MxA was abolished by overexpression of SOCS-1...
  3. pmc Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle
    J Pavlovic
    Institute for Immunology and Virology, University of Zurich, Switzerland
    J Virol 66:2564-9. 1992
    Human MxA and mouse Mx1 are interferon-induced proteins capable of inhibiting the multiplication of influenza virus. MxA protein is localized in the cytoplasm, whereas Mx1 protein accumulates in the nucleus...
  4. ncbi Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro
    M Hijikata
    Department of Medical Sciences, Toshiba General Hospital, Tokyo, Japan
    Intervirology 44:379-82. 2001
    ..position -88 (G or T) within an interferon-stimulated response element-like sequence in the promoter region of the MxA gene, which correlated with responsiveness of hepatitis C patients to interferon...
  5. ncbi Hepatitis B virus downregulates the human interferon-inducible MxA promoter through direct interaction of precore/core proteins
    Mario Fernandez
    Fundacion para el Estudio de las Hepatitis Virales, C Guzmán el Bueno 72, 28015 Madrid, Spain
    J Gen Virol 84:2073-82. 2003
    The human MxA protein is an interferon (IFN)-inducible GTPase with proven antiviral activity against diverse viruses. IFN responsiveness is impaired in chronic hepatitis B virus (HBV) infection...
  6. ncbi Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR
    S Knapp
    Hepatology Section, Faculty of Medicine, Imperial College of Science, Medicine and Technology at St Mary s Hospital, London, UK
    Genes Immun 4:411-9. 2003
    ..the expression of a number of genes encoding enzymes with antiviral activities, including myxovirus resistance-1 (MxA), 2-5-oligoadenylate synthetase 1 (OAS-1) and double-stranded RNA-dependent protein kinase (PKR)...
  7. pmc Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome
    Kadir Turan
    University of Marmara, Faculty of Pharmacy, Department of Pharmaceutical Biotechnology, Haydarpasa, Kadikoy, Istanbul 34668, Turkey
    Nucleic Acids Res 32:643-52. 2004
    ..Earlier studies show that nuclear mouse Mx1 and human MxA designed to be localized in the nucleus inhibit the transcription step of the influenza virus genome...
  8. ncbi Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis
    H Torisu
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neurology 62:457-60. 2004
    The antivirally active MxA protein is induced by interferon (IFN) alpha/beta and inhibits the replication of single-stranded RNA viruses including measles virus (MV)...
  9. ncbi The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein
    Martin Spiegel
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Clin Virol 30:211-3. 2004
    ..Interferon-alpha and interferon-gamma, by contrast, were less effective. The human MxA protein is one of the most prominent proteins induced by interferon-beta...
  10. ncbi Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population
    Emi Hamano
    Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, Japan
    Biochem Biophys Res Commun 329:1234-9. 2005
    ..single nucleotide polymorphisms (SNPs) of 2',5'-oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls...
  11. ncbi Human MxA protein participates to the interferon-related inhibition of hepatitis B virus replication in female transgenic mice
    Cécile Peltekian
    INSERM U370 Institut Pasteur, Faculte de Medecine Necker Enfants Malades, 156, rue de Vaugirard, 75015 Paris, France
    J Hepatol 43:965-72. 2005
    The interferon (IFN) inducible MxA protein is endowed with antiviral activity against a broad range of RNA viruses...
  12. doi GTPase activity is not essential for the interferon-inducible MxA protein to inhibit the replication of hepatitis B virus
    Zhijian Yu
    Department of Infectious Diseases, Nanfang Hospital, Nanfang Medical University, Guangzhou, China
    Arch Virol 153:1677-84. 2008
    Multiple studies have established that GTPase activity is critical for MxA to act against RNA viruses...
  13. ncbi Upregulation of myxovirus-resistance protein A: a possible marker of type I interferon induction in systemic sclerosis
    Paolo Airo
    Rheumatology and Clinical Immunology Service, Spedali Civili di Brescia, Brescia, Italy
    J Rheumatol 35:2192-200. 2008
    To examine whether myxovirus-resistance protein A (MxA) mRNA expression, commonly considered a reliable marker of Type I interferon (IFN) bioactivity, is modified in patients with systemic sclerosis (SSc); if it is associated to ..
  14. pmc Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial
    Tania Mara Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hepatology 49:1847-58. 2009
    ..51; P = 0.05) and a strong relationship among African American patients; all 10 with SVR who were genotyped for TYK2 -2256 carried the A variant compared with 68 of 120 (57%) nonresponders (P = 0.006)...
  15. doi Spontaneous MxA mRNA level predicts relapses in patients with recently diagnosed MS
    L F van der Voort
    VU Medical Center, Department of Neurology, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 75:1228-33. 2010
    To determine if myxovirus resistance protein A (MxA) mRNA is related to clinical disease activity in multiple sclerosis (MS).
  16. doi Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity
    Otto Haller
    Department of Virology, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    J Interferon Cytokine Res 31:79-87. 2011
    The human myxovirus resistance protein 1 (MxA) is a key mediator of the interferon-induced antiviral response against a wide range of viruses...
  17. doi Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function
    Song Gao
    Max Delbrück Centrum for Molecular Medicine, Crystallography, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Immunity 35:514-25. 2011
    Human myxovirus resistance protein 1 (MxA) is an interferon-induced dynamin-like GTPase that acts as a cell-autonomous host restriction factor against many viral pathogens including influenza viruses...
  18. pmc Myxovirus resistance gene A (MxA) expression suppresses influenza A virus replication in alpha interferon-treated primate cells
    Shannon R Matzinger
    Center for Comparative Medicine, University of California, Davis, Davis, CA, USA
    J Virol 87:1150-8. 2013
    ..The human ISG MxA can inhibit influenza A virus replication in mouse cells by interfering with a step in the virus replication cycle ..
  19. pmc MxA mRNA quantification and disability progression in interferon beta-treated multiple sclerosis patients
    Federico Serana
    CREA, Diagnostics Department, Spedali Civili of Brescia, Brescia, Italy
    PLoS ONE 9:e94794. 2014
    ..beta (IFNβ) antibodies are the main determinants of IFNβ bioactivity loss and Myxovirus-resistance protein A (MxA) is the most established marker of IFNβ biological activity in IFNβ-treated multiple sclerosis patients, their ..
  20. ncbi Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection
    F Suzuki
    Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan
    J Viral Hepat 11:271-6. 2004
    ..of intracellular antiviral proteins, such as 2'-5' oligoadenylate synthetase, dsRNA-activated protein kinase and MxA protein. Among these, MxA protein is assumed to be the most specific surrogate parameter for IFN action...
  21. pmc cDNA structures and regulation of two interferon-induced human Mx proteins
    M Aebi
    Institute for Molecular Biology I, University of Zurich, Switzerland
    Mol Cell Biol 9:5062-72. 1989
    ..as a hybridization probe, we have isolated cDNA clones originating from two distinct human Mx genes, designated MxA and MxB...
  22. ncbi Respiratory syncytial virus strain A2 is resistant to the antiviral effects of type I interferons and human MxA
    P L Atreya
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM 445, Bethesda, Maryland 20892, USA
    Virology 261:227-41. 1999
    ..A variety of negative-strand RNA virus infections, including that of PIV3, are inhibited by human MxA protein, a type I interferon (IFN)-inducible GTPase...
  23. ncbi Pharmacogenomics of responsiveness to interferon IFN-beta treatment in multiple sclerosis: a genetic screen of 100 type I interferon-inducible genes
    Stephen Cunningham
    Applied Genomics Research Group, McClay Center for Pharmaceutical Sciences, School of Pharmacy, Queen s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, N Ireland, UK
    Clin Pharmacol Ther 78:635-46. 2005
    ..We hypothesized that polymorphisms may occur within or close to ISRE elements, altering type I interferon inducibility and ultimately leading to a modified clinical response in carriers...
  24. ncbi Type I interferon-associated skin recruitment of CXCR3+ lymphocytes in dermatomyositis
    J Wenzel
    Department of Dermatology, University of Bonn, Germany
    Clin Exp Dermatol 31:576-82. 2006
    ..We hypothesized that a similar mechanism might also be involved in the pathogenesis of DM skin lesions...
  25. doi Difference in susceptibility to MxA protein between a coxsackievirus B1 isolate and prototype, impact of serial cell culture passage
    Wassim Chehadeh
    Faculty of Medicine, Virology Unit, Department of Microbiology, Kuwait University, Safat, Kuwait
    J Med Virol 82:424-32. 2010
    ..The type I interferon-induced MxA protein has been shown to inhibit the replication of an EV, coxsackievirus B4 (CVB4), but not cardioviruses such as ..
  26. ncbi Scarring skin lesions of discoid lupus erythematosus are characterized by high numbers of skin-homing cytotoxic lymphocytes associated with strong expression of the type I interferon-induced protein MxA
    J Wenzel
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Br J Dermatol 153:1011-5. 2005
    ..Because recent investigations have highlighted the relevance of cytotoxic lymphocytes in autoimmune tissue destruction, we hypothesized that the scarring CDLE lesions might be caused by cytotoxic T lymphocytes...
  27. pmc Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes
    Georg Kochs
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Proc Natl Acad Sci U S A 99:3153-8. 2002
    ..We have previously shown that the IFN-induced human MxA protein inhibits bunyavirus replication by an unknown mechanism...
  28. ncbi Type I interferons are involved in the development of ultraviolet B-induced inflammatory skin lesions in systemic lupus erythaematosus patients
    E Reefman
    Departments of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Ann Rheum Dis 67:11-18. 2008
    ..To investigate the involvement of type I interferons and endothelial cell adhesion molecules in the development of ultraviolet B (UVB)-induced systemic lupus erythaematosus (SLE) skin lesions...
  29. ncbi Comparing morphometric X-ray absorptiometry and radiography in defining vertebral wedge fractures in patients with ankylosing spondylitis
    D Vosse
    Department of Internal Medicine, Division of Rheumatology University Hospital, PO Box 58006202 AZ Maastricht, The Netherlands
    Rheumatology (Oxford) 46:1667-71. 2007
    ....
  30. ncbi Enhanced type I interferon signalling promotes Th1-biased inflammation in cutaneous lupus erythematosus
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Germany
    J Pathol 205:435-42. 2005
    ..biopsies from 21 patients suffering from different types of active cutaneous LE were analysed for the expression of MxA, a protein specifically induced by type I interferons, the IFN-inducible protein IP10/CXCL10, and the chemokine ..
  31. ncbi Type I interferon-associated cytotoxic inflammation in lichen planus
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Cutan Pathol 33:672-8. 2006
    ..Here, we investigated whether type I IFNs are also involved in the pathogenesis of LP...
  32. pmc Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane)
    Dina C Nacionales
    Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
    Am J Pathol 168:1227-40. 2006
    ..In view of the increased IFN-I production in systemic lupus erythematosus, these studies suggest that IFN-I from ectopic lymphoid tissue could play a role in the pathogenesis of experimental lupus in mice...
  33. pmc Antiviral responses of human Leydig cells to mumps virus infection or poly I:C stimulation
    A Le Tortorec
    INSERM, U625, Rennes, France
    Hum Reprod 23:2095-103. 2008
    ..The aim of this study was to test whether mumps virus infection of isolated human Leydig cells was associated with an inhibition of their innate antiviral defences...
  34. ncbi Validation of an Mx/CAT reporter gene assay for the quantification of bovine type-I interferon
    M D Fray
    Institute for Animal Health, Compton, Berkshire, RG20 7NN, Newbury, UK
    J Immunol Methods 249:235-44. 2001
    ..The assay is based on Madin-Darby Bovine Kidney cells transfected with a plasmid, containing a human MxA promoter driving a chloramphenicol acetyltransferase (CAT) cDNA...
  35. ncbi In vitro and in vivo differential expression of rainbow trout (Oncorhynchus mykiss) Mx isoforms in response to viral haemorrhagic septicaemia virus (VHSV) G gene, poly I:C and VHSV
    C Tafalla
    CISA INIA Carretera de Algete a El Casar km 8, 1, Valdeolmos, 28130 Madrid, Spain
    Fish Shellfish Immunol 23:210-21. 2007
    ..Moreover, this is also the first report showing Mx induction after cell transfection with a plasmid coding for the VHSV-G protein...
  36. ncbi Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus
    Pui Y Lee
    University of Florida College of Medicine, Gainesville, Florida, USA
    Arthritis Rheum 56:3759-69. 2007
    ....
  37. doi Genomic organisation of the channel catfish Mx1 gene and characterisation of multiple channel catfish Mx gene promoters
    Karen P Plant
    Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
    Fish Shellfish Immunol 24:575-83. 2008
    ..These results suggest that only channel catfish Mx1 is involved in the type I interferon pathway and that the presence of an ISRE in a regulatory region is not necessarily indicative of a role in the type I interferon response...
  38. pmc Gene mapping and phylogenetic analysis of the complete genome from 30 single-stranded RNA male-specific coliphages (family Leviviridae)
    Stephanie D Friedman
    U S Environmental Protection Agency, Gulf Ecology Division, 1 Sabine Island Drive, Gulf Breeze, FL 32561, USA
    J Virol 83:11233-43. 2009
    ..A conserved eight-nucleotide signature at the 3' end of the genome distinguishes leviviruses (5' ACCACCCA 3') from alloleviviruses (5' TCCTCCCA 3')...
  39. doi Induction of innate immune response and absence of subsequent tolerance to dsRNA in biliary epithelial cells relate to the pathogenesis of biliary atresia
    Kenichi Harada
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 28:614-21. 2008
    ..g. endotoxin tolerance). Viral infections of the Reoviridae genus with a dsRNA genome are suspected to be part of the aetiology of biliary atresia (BA), but the negative biliary mechanisms remain unexplored...
  40. doi The ubiquitin-proteasome pathway is important for dengue virus infection in primary human endothelial cells
    Rattiyaporn Kanlaya
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Proteome Res 9:4960-71. 2010
    ..ubiquitin-activating enzyme E1 (UBE1) and downregulated annexin A2] and an immunofluorescence study (upregulated MxA)...
  41. ncbi Inhibition of puumala and tula hantaviruses in Vero cells by MxA protein
    M Kanerva
    Haartman Institute, Department of Virology, University of Helsinki, Finland
    Virology 224:55-62. 1996
    Human MxA protein is a type I Interferon-inducible intracytoplasmic protein, which mediates antiviral actions against a variety of negative-strand RNA viruses including influenza A, measles, and vesicular stomatitis viruses...
  42. ncbi SNPs in the promoter region of the osteopontin gene as a marker predicting the efficacy of interferon-based therapies in patients with chronic hepatitis C
    Masashi Naito
    Division of Gastroenterology and Hepatology, Internal Medicine, Saitama Medical School, 38 Morohongo, Moroyama cho, Iruma gun, Saitama 350 0495, Japan
    J Gastroenterol 40:381-8. 2005
    ..Therefore, we examined the possibility that SNPs in OPN were also markers predicting the therapeutic efficacy of IFN in patients with chronic hepatitis C...
  43. pmc Herpes simplex virus type 1 Us3 gene deletion influences toll-like receptor responses in cultured monocytic cells
    Piritta Peri
    Department of Virology, University of Turku, Kiinamyllynkatu 13, 20520 Turku, Finland
    Virol J 5:140. 2008
    ..In this work, we have studied the TLR responses and effects on TLR gene expression by HSV-1 with Us3 and ICP4 gene deletions, which also subject infected cells to apoptosis in human monocytic (U937) cell cultures...
  44. pmc Coordinated regulation of SIV replication and immune responses in the CNS
    Kenneth W Witwer
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e8129. 2009
    ..i.). This was accompanied by upregulation of innate immune responses, including IFNbeta, IFNbeta-induced gene MxA mRNA, and TNFalpha...
  45. pmc Hepatitis B virus core protein with hot-spot mutations inhibit MxA gene transcription but has no effect on inhibition of virus replication by interferon α
    Yu Zhijian
    Department of Infectious Diseases, The Affiliated Shenzhen Nanshan Hospital of Guangdong Medical College, Shenzhen, China
    Virol J 7:278. 2010
    ..reported that hepatitis B virus (HBV) core protein (HBc) can inhibit the transcription of human interferon-induced MxA gene...
  46. ncbi Poly I:C induces an antiviral state against Ictalurid Herpesvirus 1 and Mx1 transcription in the channel catfish (Ictalurus punctatus)
    Karen P Plant
    Pathobiological Sciences, School of Veterinary Medicine and Department of Veterinary Science, Louisiana State University Agricultural Center, Louisiana State University, Baton Rouge, LA 70803, USA
    Dev Comp Immunol 29:627-35. 2005
    ..In response to CCV, Mx1 transcription was not significantly elevated until day 3 post-challenge, but remained elevated in certain organs until day 7...
  47. pmc Constitutive expression of Atlantic salmon Mx1 protein in CHSE-214 cells confers resistance to infectious salmon anaemia virus
    Molly J T Kibenge
    Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada
    Virol J 2:75. 2005
    ....
  48. ncbi Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes
    Philip O Scumpia
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610 0274, USA
    Glia 52:153-62. 2005
    ....
  49. pmc Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts
    Lynn M Crosby
    Environmental Carcinogenesis Division, National Health Effects and Environmental Research Laboratory, US Environmental Protection Agency, Research Triangle Park, USA
    Cancer Cell Int 10:4. 2010
    ..The commercially-available human uroepithelial cell lines were either SV40-immortalized (HUC) or SV40-immortalized and then 3-MC-transformed (HUC-TC)...
  50. doi Advances in technologies for the measurement of uranium in diverse matrices
    D P S Rathore
    Chemical Laboratory, Atomic Minerals Directorate for Exploration and Research, Department of Atomic Energy, Pratap Nagar, Sector V Extension, Sanganer, Jaipur 302030, India
    Talanta 77:9-20. 2008
    ..ion chromatography, microsample X-ray analysis method followed by energy dispersive X-ray fluorescence technique (MXA-EDXRF), sensors for electrochemical detection followed by cyclic voltammogram and alpha liquid scintillation ..
  51. ncbi Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region
    R Tazi-Ahnini
    Division of Molecular and Genetic Medicine, University of Sheffield, Royal Hallamshire Hospital, UK
    Hum Genet 106:639-45. 2000
    ..MX1 is the gene encoding the interferon-induced p78 protein (MxA)...
  52. ncbi Morphometric X-ray absorptiometry in the assessment of vertebral fractures in renal transplant patients
    Sandro Mazzaferro
    Department of Clinical Science, University La Sapienza of Rome, Italy
    Nephrol Dial Transplant 21:466-71. 2006
    ..assessed the prevalence of vertebral fractures by means of a new, DEXA-based method (morphometric absorptiometry, MXA) and compared its concordance with the two mostly employed radiological techniques (Visual semi-quantitative, SQ, ..
  53. ncbi Interferon beta treatment: bioavailability and antiviral activity in multiple sclerosis patients
    Marta Garcia-Montojo
    Servicio de Neurologia, Hospital Clinico San Carlos, Madrid, Spain
    J Neurovirol 13:504-12. 2007
    ..the bioavailability of interferon beta through the measurement of the expression of myxovirus resistance protein (MxA), metalloproteinase 9 (MMP-9), and its inhibitor (TIMP-1); (2) to analyze its antiviral efficiency through the ..
  54. doi Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity
    M Krumbholz
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
    Brain 131:1455-63. 2008
    ..IFN-beta therapy strongly induced BAFF transcription proportionally to the IFN-beta biomarker MxA in monocytes and granulocytes in vivo...
  55. pmc Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections
    H P Hefti
    Institute of Medical Virology, University of Zurich, Zurich, Switzerland
    J Virol 73:6984-91. 1999
    The human MxA protein is part of the antiviral state induced by alpha/beta interferon (IFN-alpha/beta). MxA inhibits the multiplication of several RNA viruses in cell culture...
  56. pmc Comparison of tissue-selective proinflammatory gene induction in mice infected with wild-type, DNA adenine methylase-deficient, and flagellin-deficient Salmonella enterica
    Raphael Simon
    Department of Molecular, Cellular and Developmental Biology, University of California at Santa Barbara, Santa Barbara, CA 93106, USA
    Infect Immun 75:5627-39. 2007
    ....
  57. pmc Asparagine 631 variants of the chicken Mx protein do not inhibit influenza virus replication in primary chicken embryo fibroblasts or in vitro surrogate assays
    Camilla T O Benfield
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 OES, United Kingdom
    J Virol 82:7533-9. 2008
    ..and A/Turkey/England/50-92/91 [H5N1]), which were highly sensitive to inhibition by the murine Mx1 and human MxA proteins, respectively, Shamo chicken Mx also proved ineffective in the context of avian as well as mammalian cell ..
  58. doi Structural basis of oligomerization in the stalk region of dynamin-like MxA
    Song Gao
    Max Delbrück Centrum for Molecular Medicine, Crystallography, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Nature 465:502-6. 2010
    The interferon-inducible dynamin-like myxovirus resistance protein 1 (MxA; also called MX1) GTPase is a key mediator of cell-autonomous innate immunity against pathogens such as influenza viruses...
  59. ncbi The rainbow trout (Oncorhynchus mykiss) Mx1 promoter. Structural and functional characterization
    B Collet
    Department of Zoology, University of Aberdeen, UK
    Eur J Biochem 268:1577-84. 2001
    ..A time-course of induction of this reporter construct showed maximal expression (22-fold increase) after incubation with 100 microg mL(-1) poly I:C for 48 h. An optimized method of transient transfection of RTG cells is also described...
  60. pmc Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase
    Jan Dittmann
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, 79107 Freiburg, Germany
    J Virol 82:3624-31. 2008
    ..Here we analyzed a range of influenza A virus strains for their sensitivities to murine Mx1 and human MxA proteins and found remarkable differences...
  61. ncbi Interferon-induced expression of MxA in the respiratory tract of rhesus macaques is suppressed by influenza virus replication
    Timothy D Carroll
    California National Primate Research Center, and Center for Comparative Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    J Immunol 180:2385-95. 2008
    ..However, the mRNA level of a single IFN-stimulated gene, MxA (myxovirus resistance A), the IFN-stimulated gene known to be critical in blocking influenza virus replication, was ..
  62. doi CXCR3 <-> ligand-mediated skin inflammation in cutaneous lichenoid graft-versus-host disease
    Joerg Wenzel
    Department of Dermatology at the Universitie of Bonn, Bonn, Germany
    J Am Acad Dermatol 58:437-42. 2008
    ....
  63. pmc Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses
    Markus Mordstein
    Department of Virology, University of Freiburg, Freiburg, Germany
    PLoS Pathog 4:e1000151. 2008
    ..From these results we conclude that IFN-lambda contributes to inborn resistance against viral pathogens infecting the lung but not the liver...
  64. pmc Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice
    Thierry Rolling
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, 79104 Freiburg, Germany
    J Virol 83:6673-80. 2009
    ..Interestingly, all virulence-enhancing mutations that we identified in this study resulted in substantially increased viral polymerase activity...
  65. doi High yields of influenza A virus in Madin-Darby canine kidney cells are promoted by an insufficient interferon-induced antiviral state
    Claudius Seitz
    Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
    J Gen Virol 91:1754-63. 2010
    ..In conclusion, in MDCK cells, IFN expression is not a limiting factor for influenza virus replication and this might partially be caused by a lack of anti-influenza activity of canine Mx proteins...
  66. ncbi Molecular responses of macrophages to porcine reproductive and respiratory syndrome virus infection
    X Zhang
    College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota 55108, USA
    Virology 262:152-62. 1999
    ..These tissues correspond to sites for PRRSV persistence, suggesting that the Mx1 and Ubp genes may play important roles in clinical disease during PRRSV infection...
  67. ncbi Mx1 but not MxA confers resistance against tick-borne Dhori virus in mice
    R Thimme
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany
    Virology 211:296-301. 1995
    ..The MxA protein of human cells shows a high degree of sequence similarity to Mx1 but, unlike Mx1, inhibits a broad range of ..
  68. ncbi Intrahepatic MxA expression is correlated with interferon-alpha expression in chronic and fulminant hepatitis
    L Leifeld
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Pathol 194:478-83. 2001
    ..It exerts its effects by inducing intracellular proteins such as MxA. To analyse the role of intrahepatic interferon activation, IFN-alpha and MxA expression was studied by ..
  69. ncbi Evaluation of IFNalpha bioavailability by MxA mRNA in HCV patients
    F Gilli
    Centro Sclerosi Multipla and Laboratorio di Neurobiologia Clinica, Divisione Universitaria di Neurologia, Azienda Ospedaliera S Luigi, Universita di Torino, Regione Gonzole 10, 10043 Orbassano, Italy
    J Immunol Methods 262:187-90. 2002
    ..IFNbeta) bioavailability in multiple sclerosis (MS) patients, by measuring mRNA of mixovirus resistance protein A (MxA)...
  70. pmc Rational site-directed mutations of the LLP-1 and LLP-2 lentivirus lytic peptide domains in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41 indicate common functions in cell-cell fusion but distinct roles in virion envelope incorpora
    Vandana Kalia
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Virol 77:3634-46. 2003
    ..Altogether, these results demonstrate for the first time that the highly conserved LLP domains perform critical but distinct functions in Env incorporation and fusogenicity...
  71. ncbi Expression of the antiviral protein MxA in cells transiently perturbs endocytosis
    Shashidhar S Jatiani
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400 005, India
    Biochem Biophys Res Commun 323:541-6. 2004
    b>MxA is an interferon-induced antiviral protein. Viral replication relies on the trafficking machinery of the host cell...
  72. ncbi Guidelines on use of anti-IFN-beta antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN-beta antibodies in multiple sclerosis
    P S Sørensen
    Danish Multiple Sclerosis Research Centre, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Eur J Neurol 12:817-27. 2005
    ..Measurement of NABs should be performed in specialized laboratories with a validated cytopathic effect assay or MxA production assay using serial dilution of the test sera...
  73. ncbi Interferon beta-1b (betaseron/betaferon) is well tolerated at a dose of 500 microg: interferon dose escalation assessment of safety (IDEAS)
    M H Gottesman
    Winthrop University Hospital, Old Country Road, Mineola, NY 11501, USA
    Mult Scler 12:271-80. 2006
    ..Baseline and exit assessments included the MS Functional Composite score, EDSS, and neutralizing antibody MxA assay. AEs were recorded at every injection. Dose escalation ranged from two to 12 weeks...
  74. ncbi Interferon-inducible Mx gene expression in cotton rats: cloning, characterization, and expression during influenza viral infection
    Lioubov M Pletneva
    Virion Systems, Inc, Rockville, MD 20850, USA
    J Interferon Cytokine Res 26:914-21. 2006
    ..Mx1 localized in the nucleus, whereas Mx2, as its human homolog MxA, localized in the cytoplasm...
  75. ncbi Cloning and characterizing of the ovine MX1 gene promoter/enhancer region
    A M Assiri
    Department of Animal Science, Washington State University, Pullman, Washington, USA
    Dev Comp Immunol 31:847-57. 2007
    ..Identifying positive and negative regulatory regions in MX1 promoter will help define the complex regulation of MX1 during early pregnancy in ruminants...
  76. ncbi MxA-independent inhibition of Hantaan virus replication induced by type I and type II interferon in vitro
    Robin Oelschlegel
    Institute of Virology, Helmut Ruska Haus, University Hospital Charite, Charite Campus Mitte, D 10098 Berlin, Germany
    Virus Res 127:100-5. 2007
    ..The IFN-inducible MxA is discussed to be important for control of infections with hantaviruses...
  77. doi Decreased type I interferon receptor-soluble isoform in antiretroviral-treated HIV-positive children
    Alessandra Sottini
    Laboratorio di Biotecnologie, Department of Diagnostics, Spedali Civili di Brescia, Italy
    J Interferon Cytokine Res 28:181-9. 2008
    ..patients were undergoing antiretroviral therapy and were divided into two groups on the basis of the induction of MxA mRNA, a marker of type I IFN bioactivity...
  78. doi Absence of MxA induction by interferon beta in patients with MS reflects complete loss of bioactivity
    D Hesse
    Danish Multiple Sclerosis Research Center, Department of Neurology 2082, Copenhagen University Hospital Rigshospitalet, Denmark
    Neurology 73:372-7. 2009
    ..In vivo MxA induction by IFNbeta is used as a marker of biologic response to IFNbeta...
  79. ncbi Association study of IFNAR2 and IL10RB genes with the susceptibility and interferon response in HBV infection
    Q M Gong
    Department of Infectious Diseases, School of Medicine, Shanghai Jiaotong University, Ruijin Hospital, Shanghai, China
    J Viral Hepat 16:674-80. 2009
    ..667, 95% CI: 1.148-2.420, P = 0.007). In addition, the IFNAR2-8FF genotype predisposed to higher MxA gene induction and correlated with sustained IFN response (OR = 0.348, 95% CI: 0.129-0.935, P = 0.036)...
  80. pmc Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection
    Ravesh Singh
    Doris Duke Medical Research Institute, University of KwaZulu Natal, Private Bag X7, Congella, Durban 4001, South Africa
    J Virol 85:208-16. 2011
    ..We measured IFN-α, IFN-β, myxovirus resistance protein A (MxA), human TRIM5α (huTRIM5α), and TRIM22 mRNA levels in peripheral blood mononuclear cells (PBMCs) of high-risk, HIV-..
  81. pmc A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice
    Natalya Lyubynska
    Department of Pediatrics, University of California, San Francisco, CA 94158, USA
    Sci Transl Med 3:76ra27. 2011
    ....
  82. doi Three Mx genes with differential response to VNNV infection have been identified in Gilthead seabream (Sparus aurata)
    M A Fernández-Trujillo
    Department of Genetics, Faculty of Sciences, University of Malaga, 29071 Malaga, Spain
    Mol Immunol 48:1216-23. 2011
    ....
  83. doi Ovine corpus luteum proteins, with functions including oxidative stress and lipid metabolism, show complex alterations during implantation
    Mitra Arianmanesh
    Division of Applied Medicine, Institute of Medical Sciences, Centre for Reproductive Endocrinology and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    J Endocrinol 210:47-58. 2011
    ..These proteins are most likely involved with mechanisms allowing the CL to produce P(4) during early pregnancy...
  84. pmc A nuclear localization of the infectious haematopoietic necrosis virus NV protein is necessary for optimal viral growth
    Myeong Kyu Choi
    Department of Biological Sciences, University of Ulsan, Ulsan, Korea
    PLoS ONE 6:e22362. 2011
    ..These data suggest that the IHNV NV may support the growth of IHNV through inhibition of the INF system and the amino acid residues of (32)EGDL(35) responsible for nuclear localization are important for the inhibitory activity of NV...
  85. pmc Influenza virus pathophysiology and brain invasion in mice with functional and dysfunctional Mx1 genes
    Nicole R Hodgson
    Sleep and Performance Research Center, WWAMI Medical Education Program, Washington State University, Spokane, WA 99210 1495, United States
    Brain Behav Immun 26:83-9. 2012
    ..Inflammation was similar in OBs and lungs of both strains at 15 h but by 96 h it was suppressed in lungs, but not in OBs, of fMx1 mice...
  86. ncbi Epidemiologic and genetic characteristics of alopecia areata (part 2)
    Abdullateef A Alzolibani
    Department of Dermatology, College of Medicine, Qassim University, Buraidah, Saudi Arabia
    Acta Dermatovenerol Alp Pannonica Adriat 21:15-9. 2012
    ..MX1 is another new candidate gene in AA. Thus, this second part of the review completes the overview of current knowledge about the molecular genetics of AA begun in the first part...
  87. pmc Genomic analysis of between-cow variation in dermal fibroblast response to lipopolysaccharide
    S Kandasamy
    Department of Animal Science, College of Agriculture and Life Sciences, University of Vermont, Burlington 05405, USA
    J Dairy Sci 95:3852-64. 2012
    ..Also, the primary dermal fibroblast cells can be used to examine underlying causes for between-cow variations in key immune response pathways...
  88. pmc Global secretome characterization of herpes simplex virus 1-infected human primary macrophages
    Juho J Miettinen
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    J Virol 86:12770-8. 2012
    ..2 (IFIT2), IFIT3, signal transducer and activator of transcription 1 (STAT1), and myxovirus resistance protein A (MxA), implicating that these proteins also have important extracellular antiviral functions...
  89. doi The ventral nerve cord in Cephalocarida (Crustacea): new insights into the ground pattern of Tetraconata
    Martin E J Stegner
    Universitat Rostock, Institut für Biowissenschaften, Allgemeine und Spezielle Zoologie, Universitatsplatz 2, 18055, Rostock, Mecklenburg Vorpommern, Germany
    J Morphol 275:269-94. 2014
    ....
  90. doi Effects of florfenicol on the immune responses and the interferon-inducible genes in broiler chickens under the impact of E. coli infection
    Ola Hassanin
    Department of Avian and Rabbit Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt
    Vet Res Commun 38:51-8. 2014
    ..Additionally, it can exert up regulation effect on the chicken innate immune response with moderate hypoplasia of the bone marrow cells...
  91. doi MicroRNA-130a inhibits HCV replication by restoring the innate immune response
    S Li
    The Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China
    J Viral Hepat 21:121-8. 2014
    ..Over expression of miR-130a upregulated the expression of type I IFN (IFN-α/IFN -β), ISG15, USP18 and MxA, which are involved in innate immune response and decreased expression of miR-122, a well-defined miRNA promoting ..
  92. pmc Inefficient type I interferon-mediated antiviral protection of primary mouse neurons is associated with the lack of apolipoprotein l9 expression
    Marguerite Kreit
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    J Virol 88:3874-84. 2014
    ..Therefore, we identified a new antiviral protein induced by interferon, ApoL9b, whose lack of expression in primary neurons likely contributes to the high sensitivity of these cells to viral infection...
  93. doi Conceptus-induced changes in the gene expression of blood immune cells and the ultrasound-accessed luteal function in beef cattle: how early can we detect pregnancy?
    Guilherme Pugliesi
    Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Pirassununga, Sao Paulo, Brazil Laboratory of Theriogenology Dr O J Ginther, Department of Veterinary, School of Animal and Food Sciences, University of Sao Paulo, Pirassununga, Sao Paulo, Brazil
    Biol Reprod 91:95. 2014
    ..The level of accuracy for our described pregnancy methods is high on Day 20 (80%-91%), but only the Doppler imaging method results in an absence of false-negative diagnoses. ..
  94. doi The gene expression profile of porcine alveolar macrophages infected with a highly pathogenic porcine reproductive and respiratory syndrome virus indicates overstimulation of the innate immune system by the virus
    Yan Xiao
    State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, No 427 Maduan Street, Nangang District, Harbin, 150001, China
    Arch Virol 160:649-62. 2015
    ..The results indicate that HP-PRRSV infection excessively stimulates genes involved in the innate immune response, including proinflammatory cytokines and chemokines. ..
  95. doi Blastic plasmacytoid dendritic cell neoplasm presenting as leukemia without cutaneous involvement in a 25 years male patient: Unusual presentation of a rare entity
    Sumaira Qayoom
    Department of Hematology, SGPGI, Lucknow, Uttar Pradesh, India
    Indian J Pathol Microbiol 58:377-80. 2015
    ..dendritic cells like CD123, TCL1, BDCA2/CD303, cutaneous lymphocyte-associated and interferon dependent molecule MxA, in absence of any other lineage specific marker confirms the diagnosis...
  96. doi IFNλ Stimulates MxA Production in Human Dermal Fibroblasts via a MAPK-Dependent STAT1-Independent Mechanism
    Adewonuola A Alase
    Centre for Skin Sciences, Faculty of Life Sciences, University of Bradford, Bradford, UK
    J Invest Dermatol 135:2935-43. 2015
    ..In dermal fibroblasts, IFNλ induced the expression of myxovirus protein A (MxA), a potent antiviral factor, but not other IFN signature genes as it does in primary keratinocytes...
  97. doi Positive regulation of humoral and innate immune responses induced by inactivated Avian Influenza Virus vaccine in broiler chickens
    Fatma Abdallah
    Department of Virology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 445119, Egypt
    Vet Res Commun 39:211-6. 2015
    ..So far, from our results it appears that the inactivated H5N1 vaccine can trigger the chicken interferon-alpha signaling pathway as well as it can elicit protective humoral antibody responses...
  98. doi Influence of MX1 promoter rs2071430 G/T polymorphism on susceptibility to systemic lupus erythematosus
    Suad Alfadhli
    Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, PO Box 31470, Sulaibekhat, Kuwait
    Clin Rheumatol 35:623-9. 2016
    ..017, OR = 4.28, 95 % CI 1.30-14.06). None of the other tested variants showed any significant association with SLE. The present study is the first to reveal the influence of genetic variation in MX1 gene in susceptibility to SLE...
  99. pmc In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis
    Hong Guo
    Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 11:e0150809. 2016
    ..These findings demonstrate a critical role for the +37 kb Cebpa enhancer for hematopoietic-specific Cebpa expression, with enhancer deletion leading to impaired myelopoiesis and potentially preleukemic progenitor expansion. ..
  100. doi Effect of manipulating progesterone before timed artificial insemination on reproductive and endocrine parameters in seasonal-calving, pasture-based Holstein-Friesian cows
    P M Fricke
    Department of Dairy Science, University of Wisconsin Madison, Madison 53706 Electronic address
    J Dairy Sci 99:6780-92. 2016
    ....
  101. pmc Induction of IFNT-Stimulated Genes by Conceptus-Derived Exosomes during the Attachment Period
    Keigo Nakamura
    Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Ibaraki, Japan
    PLoS ONE 11:e0158278. 2016
    ..These results suggest that exosomes secreted from conceptuses as well as endometria are involved in cell to cell interactions for conceptus implantation to the maternal endometrium. ..

Research Grants33

  1. Does Diabetic Hyperglycemia Regulate Atherosclerosis Progression and Regression?
    ROBERT RAFFAI; Fiscal Year: 2013
    ..Our long-term goals are to identify mechanisms that could serve as therapeutic targets to delay the progression and accelerate the regression of atherosclerosis as treatments for PAD in diabetic individuals. ..
  2. IFN-a and pDC in HIV infection: impact on T cell development and reconstitution
    Christel H Uittenbogaart; Fiscal Year: 2013
    ..thymocytes and plasmacytoid dendritic cells (pDC) constitutively express IFN-?? and its secondary response protein MxA at low levels...
  3. Cheng Kui Qu; Fiscal Year: 2016
    ..In addition, the information gathered will lead to a better understanding of the pathophysiology of blood disorders resulting from mitochondrial dysfunction and metabolic conditions. ..
  4. Jun Xu; Fiscal Year: 2015
    ....
  5. James T Handa; Fiscal Year: 2015
    ..Targeted therapy that maintains a protective complement response and limits apoptosis without unwanted inflammation is expected to result from this work. ..
  6. Dongsu Park; Fiscal Year: 2016
    ..3. Test the role of osteogenic stem cells in bone loss diseases. By studying three specific, clinically relevan questions, we will further define new biological and clinical insights of osteogenic stem cells in physiological conditions. ..
  7. Mone Zaidi; Fiscal Year: 2016
    ....
  8. Functional Genomics of the Cavernous Malformation Gene
    Murat Gunel; Fiscal Year: 2013
    ..The proposed experiments are focused on identifying the molecular pathways relevant to CCM disease and on studying these pathways in vivo with a long-term goal of defining new and more effective therapies. ..
  9. In Vivo Analysis of Oncogenic Kras in Leukemogenesis
    BENJAMIN BRAUN; Fiscal Year: 2009
    ..abstract_text> ..
  10. Kevin M Shannon; Fiscal Year: 2016
    ..abstract_text> ..
  11. CAAX Processing Enzymes as Anticancer Targets
    Stephen Young; Fiscal Year: 2005
    ..Using these mice, we will define the impact of defective CAAX processing on the development, progression, and lethality of Ras-induced myeloproliferative disease. ..
  12. Role of Bacteria in production of ET-743 in E. turbinata
    Margo Haygood; Fiscal Year: 2006
    ..The specific aims are to: 1. Identify, characterize and cultivate the ET-743 producing bacterial symbiont of E. turbinata 2. Identify and clone ET-743 biosynthetic pathway genes. ..
  13. Alphavirus Minus Strand RNA Synthesis and RNase L
    DOROTHEA SAWICKI; Fiscal Year: 2009
    ..Together, the results will elucidate the innate response to alphavirus infection and the role of the host RNase L and the viral nsP2 protein in its outcome. ..
  14. Oncogenic Ras in Mouse Models of Leukemia
    Iris Chan; Fiscal Year: 2006
    ..abstract_text> ..
  15. LENTIVIRUS-INDUCED NEUROPATHY: VIRAL DIVERSITY AND HOST*
    Christopher Power; Fiscal Year: 2004
    ..From these studies, we expect to gain insights into this common neurological complication in terms of lentivirus-induced neurovirulence and pathogenic host responses. ..
  16. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
    ..Many of the scientific techniques and models to be employed in the experiments described herein are unique to the laboratories of this team of investigators who have worked together for many years. ..
  17. NEUROTOXIC MECHANISMS MEDIATED BY LENTIVIRUS-INDUCED PROTEOLYSIS
    Christopher Power; Fiscal Year: 2008
    ..The information derived from this proposal will be applicable to the prevention and treatment of HIV-associated brain disease. [unreadable] [unreadable]..
  18. Iron Homeostasis and its Involvement in C1 Metabolism
    Elizabeth Skovran; Fiscal Year: 2007
    ..extorquens AM1. [unreadable] [unreadable] [unreadable]..
  19. Oxidative stress and aortic valve disease
    Jordan Miller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. Superoxide and Vascular Function in Heart Failure
    Jordan Miller; Fiscal Year: 2007
    ..Collectively, these studies will lend important insights into the role of oxidative stress and vascular function in HF. [unreadable] [unreadable] [unreadable]..
  21. DEVELOPMENTAL EXPRESSION OF NOVOCANS
    Sara Szuchet; Fiscal Year: 2002
    ..This, in turn, would open up new avenues of research concerning the biology of ependymal cells and their role in subventricular zone neurogenesis. ..
  22. Skeletal Biology and Medicine Conference
    Mone Zaidi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  23. The Role of NFATc1 and Calcineurin in Bone Remodeling
    Mone Zaidi; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. An Adjuvanted Therapeutic DNA Vaccine for AIDS
    Michael Murphey Corb; Fiscal Year: 2006
    ..abstract_text> ..
  25. Skeletal Development and Remodeling in Health, Disease and Aging
    Mone Zaidi; Fiscal Year: 2005
    ..A local forum, which will provide the non-scientific public an informal opportunity to learn about the latest research and therapies emerging in the field, is also planned. ..
  26. Adjuvanted Epitope Vaccine to Target HIV Reservoirs
    Michael Murphey Corb; Fiscal Year: 2006
    ..Together, these studies will both define the nature of viral persistence during chronic infection and identify an effective method of treatment. ..
  27. Differential cytokine responses in Hep C patients.
    Milton Taylor; Fiscal Year: 2005
    ..We will attempt to establish an in vitro system that mimics in vivo events. This combination of experiments should identify factors that are important in the differential responses to treatment and viral resistance. ..
  28. ATP-DEPENDENT PROTEIN KINASES IN GRAM-POSITIVE BACTERIA
    Milton Saier; Fiscal Year: 2004
    ..abstract_text> ..
  29. A Novel Scrambled Antigen DNA Vaccine (SAVINE) Strategy
    Michael Murphey Corb; Fiscal Year: 2003
    ..Together, these experiments will provide data essential to the translation of these studies to human trials. ..
  30. CD38/ADP RIBOSYL CYCLASE R0LE IN OSTEOCLAST REGULATION
    Mone Zaidi; Fiscal Year: 2003
    ..Taken together, the studies should provide mechanistic insights into the role of the NAD+/CD38/cADPr/Ca2+ system in osteoclast control. ..
  31. In vivo microcomputed tomography
    Kurt Hankenson; Fiscal Year: 2008
    ..Information gained from studying rodent musculoskeletal, cancer, and metabolic diseases will have direct translational application to better understanding similar disease states in humans. [unreadable] [unreadable] [unreadable]..
  32. Gene Expression in Inflammatory Myopathies
    Steven Greenberg; Fiscal Year: 2005
    ..This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis. ..

Patents1

  1. Interferon-induced human protein in pure form, monoclonal antibodies thereto, and test kits containing these antibodies
    Patent Number: EP0242329-A2; Date:1987-10-21