Genomes and Genes
Gene Symbol: NAT2
Description: N-acetyltransferase 2
Alias: AAC2, NAT-2, PNAT, arylamine N-acetyltransferase 2, N-acetyltransferase 2 (arylamine N-acetyltransferase), N-acetyltransferase type 2, arylamide acetylase 2
Publications267 found, 100 shown here
- A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancerHeather M Ochs-Balcom
Department of Epidemiology and Biostatistics, Case Western Reserve University, and Ireland Comprehensive Cancer Center at University Hospitals of Cleveland, OH 44106 7281, USA
Am J Epidemiol 166:246-54. 2007The N-acetyltransferase 2 gene (NAT2) product is an enzyme important in carcinogen metabolism via activation and detoxification pathways. Therefore, NAT2 variants may represent underlying susceptibility to breast cancer...
- NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analysesMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
Lancet 366:649-59. 2005..An exception could be the association between NAT2 slow acetylation, GSTM1 null genotype, and bladder-cancer risk...
- [A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer]Kun Chen
Departent of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310031, China
Zhonghua Liu Xing Bing Xue Za Zhi 26:659-64. 2005..To investigate the association between metabolic enzymes polymorphisms and the risk of colorectal cancer(CRC)...
- Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and NorwayHalla Skuladottir
Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
Lung Cancer 48:187-99. 2005..and polymorphisms in following genotypes were determined GSTM1, GSTM3, GSTP1, GSTT1, GPX1, MPO, NQO1 and NAT2. Based on the literature, the alleles of the genotypes were categorised as high- or low-risk alleles...
- Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotypeSilvia Selinski
Leibniz Research Centre for Working Environment and Human Factors IfADo, Dortmund, Germany
Pharmacogenet Genomics 21:673-8. 2011Genotyping N-acetyltransferase 2 (NAT2) is of high relevance for individualized dosing of antituberculosis drugs and bladder cancer epidemiology...
- Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smokingKana Yoshida
Faculty of Health Sciences, Kobe University Graduate School of Medicine, 7 10 2 Tomogaoka, Sumaku, Kobe 654 0142, Japan
Asian Pac J Cancer Prev 8:438-44. 2007We investigated CYP1A1*2A, CYP1A1*2C, CYP1A2*1C, CYP1A2*1F, GSTM1 and NAT2 gene polymorphisms, involving enzymes which metabolize many carcinogens, with reference to colorectal cancer risk...
- Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer riskMichelle Cotterchio
Population Studies and Surveillance, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada, M5G 2L7
Cancer Epidemiol Biomarkers Prev 17:3098-107. 2008..CYP2C9 and NAT2 variants were associated with colorectal cancer risk...
- Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic studyLesley M Butler
University of California Davis, Department of Public Health Sciences, Division of Epidemiology, Davis, CA 95616, USA
Mutat Res 638:162-74. 2008..We examined whether our previously reported associations between meat-derived heterocyclic amine (HCA) intake and colon cancer were modified by N-acetyltransferase 1 (NAT1) or 2 (NAT2) genotypes and whether there were differences by race.
- Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancerIstvan Kiss
Department of Public Health, Faculty of Medicine, Pécs University of Sciences, Pecs, Hungary
Anticancer Res 24:3965-70. 2004..We evaluated the effect of GSTM1, GSTT1, GSTP1, NAT1 and NAT2 enzymes on individual susceptibility to colorectal cancer, with particular attention to possible interactions ..
- Sequence variants of NAT1 and NAT2 and other xenometabolic genes and risk of lung and aerodigestive tract cancers in Central EuropeJames D McKay
Association for International Cancer Research, 150 cours Albert Thomas, Lyon Cedex 08, France
Cancer Epidemiol Biomarkers Prev 17:141-7. 2008..78; 95%CI, 0.65-0.95). In NAT2, when considering the individuals inferred acetylator phenotypes based on their NAT2 diplotype, "slow" acetylators ..
- Interethnic and intraethnic variability of NAT2 single nucleotide polymorphismsElena Garcia-Martin
Department of Biochemistry and Molecular Biology and Genetics, School of Biological Sciences, University of Extremadura, Avda de Elvas s n, E 06071, Badajoz, Spain
Curr Drug Metab 9:487-97. 2008Genetic polymorphisms of human arylamine N-acetyltransferase 2 (NAT2) are responsible for interindividual variation in the acetylation of numerous drugs and in the transformation of aromatic and heterocyclic amines into carcinogenic ..
- The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studiesK F Windmill
Department of Physiology and Pharmacology, University of Queensland, Brisbone, Australia
Mutat Res 376:153-60. 1997..metabolism can involve both N, O-acetylation and N, O-sulfonation catalyzed by N-acetyltransferases (NAT1 and NAT2) and sulfotransferases, respectively...
- Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort studyUte Nöthlings
Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
Cancer Epidemiol Biomarkers Prev 18:2098-106. 2009..We investigated the modifying effects of NAT1 and NAT2 polymorphisms on the association of meat consumption, heterocyclic amine intake, and smoking with colorectal cancer ..
- Association of polymorphism in cytochrome P450 2D6 and N-acetyltransferase-2 with Parkinson's diseaseMadhu Singh
Developmental Toxicology Division, Indian Institute of Toxicology Research formerly Industrial Toxicology Research Centre, CSIR, PO Box 80, MG Marg, Lucknow 226 001, India
Dis Markers 28:87-93. 2010..out to investigate the association of polymorphism in cytochrome P450 2D6 (CYP2D6) and N-acteyltransferase-2 (NAT2}, that are involved in the metabolism and detoxification of chemicals causing Parkinson disease (PD) like symptoms, ..
- Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosolJ W Rodriguez
Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, GA 30310
Arch Toxicol 67:445-52. 1993..e., approximately 25% Black and 75% White). The polymorphic N-acetyltransferase gene (NAT2) was amplified by the polymerase chain reaction from DNA templates derived from human colons of colorectal and non-..
- Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-AmericansD A Bell
Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
Carcinogenesis 14:1689-92. 1993..The presence of two germline copies of any of several mutant alleles of the NAT2 gene produces a slow-acetylation phenotype...
- Chromosomal localization of human genes for arylamine N-acetyltransferaseD Hickman
MRC Human Biochemical Genetics Unit UCL, Galton Laboratory, London, U K
Biochem J 297:441-5. 1994..The hybridization patterns allow assignment of AAC-1 and AAC-2 to chromosome 8p21.3-23.1, a region in which deletions have been associated with bladder cancer [Knowles, Shaw and Proctor (1993) Oncogene 8, 1357-1364]...
- Arylamine N-acetyltransferase type 2 and glutathione S-transferases M1 and T1 polymorphisms in familial adenomatous polyposisChristof Lamberti
Institute of Human Genetics, University of Bonn, Bonn, Germany
Pharmacogenetics 12:49-54. 2002..We examined whether the polymorphisms of the NAT2, GSTM1, and GSTT1 enzymes affect age at diagnosis of first colorectal adenomas or extracolonic manifestations in ..
- Strong association between N-acetyltransferase 2 genotype and PD in Hong Kong ChineseD K Y Chan
University of New South Wales, Bankstown Hospital, Bankstown, New South Wales, Australia
Neurology 60:1002-5. 2003The slow acetylator genotype for N-acetyltransferase 2 (NAT2 genotype) may be associated with PD in white subjects and the genotype is common in both white and Chinese populations...
- Re-investigation of the concordance of human NAT2 phenotypes and genotypesHermann M Bolt
Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Ardeystr 67, 44139, Dortmund, Germany
Arch Toxicol 79:196-200. 2005A comparative study of N-acetyltransferase 2 (NAT2) genotyping and phenotyping (caffeine test method) was performed on 211 persons to elucidate apparent discrepancies in the assignment of NAT2*12 and NAT2*13 alleles which occur in the ..
- NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in TaiwanHui Ling Chiou
School of Medical Technology, Chung Shan Medical University, Taichung, Taiwan, ROC
Cancer Lett 223:93-101. 2005..The association of genetic polymorphisms of CYP1A2 and NAT2, two major enzymes responsible for the metabolism of heterocyclic amines, with lung cancer has been investigated ..
- N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's diseaseJuergen Borlak
Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai Fuchs Strasse 1, 30625 Hannover, Germany
BMC Med Genet 7:30. 2006..Sequence variations in N-acetyltransferase 2 (NAT2) gene leading to slow acetylation process have been associated with PD, but results are contradictory.
- NAT2 polymorphism and gastric cancer susceptibility: a meta-analysisXu Zhong
Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Arch Med Res 41:275-80. 2010N-acetyltransferase 2 (NAT2) is a polymorphic enzyme that plays an important role in the metabolism of various potential carcinogens. NAT2 can be subdivided into rapid and slow acetylation phenotype according to the different genotypes...
- Sequences and expression of alleles of polymorphic arylamine N-acetyltransferase of human liverT Deguchi
Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neurosciences, Japan
J Biol Chem 267:18140-7. 1992..Expression studies of the alleles in Chinese hamster ovary cells show that allele 1 expresses high levels of N-acetyltransferase activity and enzyme protein, while alleles 2 and 3 express low levels of both protein and activity...
- Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) geneH J Lin
Department of Pediatrics, Harbor UCLA Medical Center, Torrance 90502
Pharmacogenetics 4:125-34. 1994..We identified two additional NAT2 mutations, suggesting that other rare alleles are likely to be found.
- Arylamine N-acetyltransferase 2 polymorphism in the ethnic populations of South IndiaA Anitha
Rajiv Gandhi Center for Biotechnology, Poojappura, Trivandrum 695 014, India
Int J Mol Med 11:125-31. 2003..Acetylation polymorphism arises from the allelic variations in human arylamine N-acetyltransferase 2 gene (NAT2), which results in the production of NAT2 proteins with variable enzyme activity or stability...
- NAT2 slow acetylation and GSTM1 null genotypes may increase postmenopausal breast cancer risk in long-term smoking womenOlga L van der Hel
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
Pharmacogenetics 13:399-407. 2003..However, compared to individuals with rapid NAT2 genotype, women with the very slow acetylator genotype (NAT2*5), who smoked for 20 years showed an increased breast ..
- N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulphasalazine in the treatment of inflammatory bowel diseaseMin Chen
Wuhan University Zhongnan Hospital, Wuhan, People s Republic China
Can J Gastroenterol 21:155-8. 2007N-acetyltransferase 2 (NAT2) is an important enzyme catalyzing N-acetylation of sulfasalazine (SASP)...
- Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE reviewS C Cotton
Department of Medicine and Therapeutics, Faculty of Medicine and Medical Sciences, University of Aberdeen, Scotland
Am J Epidemiol 151:7-32. 2000..These finding require confirmation. Methods for determining GSTM1 and GSTT1 genotype are well established. Population testing is not currently justified...
- Genetic polymorphisms in N-acetyltransferase-2 and microsomal epoxide hydrolase, cumulative cigarette smoking, and lung cancerWei Zhou
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 11:15-21. 2002N-acetyltrasferase-2 (NAT2) and microsomal epoxide hydrolase (mEH) are polymorphic genes that metabolize different tobacco carcinogens...
- Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effectsAlice Matimba
African Institute of Biomedical Science and Technology AiBST, Harare, Zimbabwe
Hum Genomics 3:169-90. 2009..The aim of the present study was to search for novel variants of CYP2C9 , CYP2C19 , CYP2D6 and NAT2 genes in Africans, with a particular focus on their prevalence in different populations, their relevance to enzyme ..
- N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breastJ A Williams
Institute of Cancer Research, Haddow Laboratories, Sutton, UK
Pharmacogenetics 11:373-88. 2001..Immunohistochemical staining of sections of breast tissue identified expression of NAT1 and NAT2 protein in human mammary epithelial cells, but not in the stroma...
- Metabolic gene polymorphism frequencies in control populationsS Garte
Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
Cancer Epidemiol Biomarkers Prev 10:1239-48. 2001..genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined...
- N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma riskHarriet Wikman
Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
Pharmacogenetics 12:227-33. 2002..The NAT2 genotype did not have any significant effect on the risk of developing asthma, but the putative slow acetylator ..
- A slow acetylator genotype associated with an increased risk of advanced cervical cancerSandra Costa
Unit of Molecular Oncology, Portuguese Institute of Oncology, Laboratórios Piso 4, Rua Dr Bernardino de Almeida, 4200 072 Porto, Portugal
J Cancer Res Clin Oncol 128:678-82. 2002..N-acetyltransferase 2 (NAT2) has an important role in the metabolism of several carcinogens...
- Variable drug metabolism genes in Arab populationR Bu
King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Pharmacogenomics J 4:260-6. 2004..We used PCR analysis to catalog the frequencies of alleles and genotypes for CYP1A1, NAT2, GSTs, MTHFR, MTR (MS) and NQO*1 in Arabs...
- GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk populationRayjean J Hung
International Agency for Research on Cancer, Lyon, France
Int J Cancer 110:598-604. 2004..Two N-acetyltransferase isozymes, NAT2 and NAT1, have major roles in catalyzing the N-acetylation and O-acetylation of aromatic amines...
- Arylamine N-acetyltransferase 2 slow acetylator polymorphisms in unrelated Iranian individualsValery V Bakayev
Department of Pathology, National Research Institute of Tuberculosis and Lung Disease, Shaheed Beheshti University of Medical Sciences and Health Services, Darabad, Tehran, Islamic Republic of Iran
Eur J Clin Pharmacol 60:467-71. 2004To determine the frequency of mutations at the polymorphic gene coding for arylamine N-acetyltransferase 2 (NAT2, EC 184.108.40.206) and NAT2 genotypes associated with slow acetylation in healthy Iranian individuals.
- Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands)Olga L van der Hel
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
Cancer Causes Control 16:675-81. 2005Variants in the metabolic genes NAT1, NAT2, GSTM1 or GSTT1, may cause differences in individual detoxifying capacity of possible carcinogens...
- Genetic polymorphism of the N-acetyltransferase 2 gene, and susceptibility to prostate cancer: a pilot study in north Indian populationDaya S L Srivastava
Department of Urology Sanjay Gandhi post Graduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
BMC Urol 5:12. 2005..This study was conducted to examine; (1) whether the N-acetyltransferase 2 (NAT2) genotype is a risk factor for prostate cancer, (2) to study effect of NAT2 genotype on modifying prostate cancer ..
- Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 geneHaruhisa Machida
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
World J Gastroenterol 11:4833-7. 2005To investigate the frequency and distribution of N-acetyltransferase 2 (NAT2) and uridine 5'-diphosphate (UDP)-glucuronosyltransferase 1A7 (UGT1A7) genes in patients with ulcerative colitis (UC) and Crohn's disease (CD).
- Is the association between cigarette smoking and breast cancer modified by genotype? A review of epidemiologic studies and meta-analysisPaul D Terry
Department of Epidemiology, Emory University School of Public Health, Atlanta, GA 30322, USA
Cancer Epidemiol Biomarkers Prev 15:602-11. 2006..In particular, 14 epidemiologic studies have tended to show positive associations with long-term smoking among NAT2 slow acetylators, especially among postmenopausal women...
- Basal and induced micronucleus frequencies in human lymphocytes with different GST and NAT2 genetic backgroundsAlba Hernandez
Grup de Mutagenesi, Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Bellaterra, Spain
Mutat Res 606:12-20. 2006..NAT) genes have been associated with cancer risk, we explored the possible links between GSTM1, GSTP1, GSTT1 and NAT2 variants and the frequency of micronuclei (MN) in human lymphocytes...
- Identification of N-acetyltransferase 2 (NAT2) transcription start sites and quantitation of NAT2-specific mRNA in human tissuesAnwar Husain
Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292, USA
Drug Metab Dispos 35:721-7. 2007Human N-acetyltransferase 2 (NAT2) genetic polymorphism is associated with drug toxicity and/or carcinogenesis in various tissues. Knowledge of NAT2 gene structure and expression is critical for understanding these associations...
- Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysisChristine B Ambrosone
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Epidemiol Biomarkers Prev 17:15-26. 2008..10 years ago, it was noted that smoking increased risk of breast cancer among women with N-acetyltransferase 2 (NAT2) slow acetylation genotypes. This report was followed by a number of studies to address this question...
- Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2J M Dupret
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Canada
J Biol Chem 267:7381-5. 1992The single coding exons of the cloned genes encoding two human arylamine N-acetyltransferases (NAT1 and NAT2) were amplified by expression-cassette polymerase chain reaction and subcloned into the tac promoter-based phagemid vector pKEN2 ..
- N-Acetyltransferase-2 genetic polymorphism, well-done meat intake, and breast cancer risk among postmenopausal womenA C Deitz
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Kentucky 40292, USA
Cancer Epidemiol Biomarkers Prev 9:905-10. 2000..Polymorphic N-acetyltransferase-2 (NAT2) catalyzes the activation of heterocyclic amines via O-acetylation, suggesting that NAT2 genotypes with high O-..
- N-acetyltransferase 2 (NAT2) genotype and colorectal carcinoma: risk variability according to tumour site?- Agúndez JAG
Dept of Pharmacology, School of Medicine, University of Extremadura, Badajoz, Spain
Scand J Gastroenterol 35:1087-91. 2000..The polymorphic N-acetyltransferase 2 enzyme (NAT2, E.C. 220.127.116.11) plays a key role in the transformation of HAAs to ultimate carcinogens...
- Analysis of six SNPs of NAT2 in Ngawbe and Embera Amerindians of Panama and determination of the Embera acetylation phenotype using caffeineLucia F Jorge-Nebert
DNA and Human Genomics Institute, University of Panama, Panama, Republic of Panama
Pharmacogenetics 12:39-48. 2002Six NAT2 single-nucleotide polymorphisms (SNPs) were analysed in 105 unrelated Ngawbe and 136 unrelated Embera Amerindians (482 chromosomes) by SNP-specific polymerase chain reaction analysis...
- Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitisYi Shin Huang
Division of Gastroenterology, Department of Medicine, and Chest Department, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
Hepatology 35:883-9. 2002..To determine whether acetylator status is a risk factor for antituberculosis drug-induced hepatitis, we genotyped NAT2 in 224 incident tuberculosis patients who received antituberculosis treatment...
- Meat consumption, cigarette smoking, and genetic susceptibility in the etiology of colorectal cancer: results from a Dutch prospective studyEdine W Tiemersma
Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
Cancer Causes Control 13:383-93. 2002We evaluated the effect of meat consumption and cigarette smoking in combination with N-acetyltransferases 1 and 2 (NAT1 and NAT2), and glutathione S-transferase M1 (GSTM1) genotypes on colorectal cancer.
- Meta-analysis of 20 case-control studies on the N-acetyltransferase 2 acetylation status and colorectal cancer riskZheng Ye
Bioinformatics Group, Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea, UK
Med Sci Monit 8:CR558-65. 2002Rapid NAT2 acetylation has been considered as a risk factor for developing colon cancer in a number of studies, however the overall results of such studies are inconsistent...
- Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control studyDavid W Hein
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Environ Mol Mutagen 40:161-7. 2002N-acetyltransferase-1 (NAT1) and N-acetyltransferase-2 (NAT2) are important in the metabolism of aromatic and heterocyclic amine carcinogens that induce prostate tumors in the rat...
- Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese populationShogo Ozawa
Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
Int J Cancer 102:418-21. 2002..and O-acetylation by phenol sulfating sulfotransferase, ST1A3 (SULT1A1), and arylamine N-acetyltransferase, NAT2, respectively...
- A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancerChristoph Sachse
Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Carcinogenesis 23:1839-49. 2002..glutathione S-transferase (GSTM1, GSTP1 and GSTT1), sulfotransferase (SULT1A1 and SULT1A2), N-acetyl transferase 2 (NAT2), NAD(P)H:quinone oxidoreductase (NQO1), methylenetetrahydrofolate reductase (MTHFR), and microsomal epoxide ..
- Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancerJ H Barrett
Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
Carcinogenesis 24:275-82. 2003Fast N-acetyltransferase 2 (NAT2) acetylators may be at increased risk of colorectal cancer through the activation of carcinogenic heterocyclic amines (HA), which are produced by meat cooked at high temperatures and are found in cigarette ..
- Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancerDonghui Li
Department of Gastrointestinal Medical Oncology, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, Houston, TX 77030, USA
Carcinogenesis 27:103-11. 2006..e. cytochrome P450 1A2 (CYP1A2) and N-acetyltransferase 1 and 2 (NAT1 and NAT2), in a hospital-based case-control study of 365 patients with pancreatic adenocarcinoma and 379 frequency-matched ..
- Association of N-acetyl transferase 2 gene polymorphism and slow acetylator phenotype with young onset and late onset Parkinson's disease among IndiansShashi Chaudhary
Department of Genetics, University of Delhi South Campus, New Delhi, India
Pharmacogenet Genomics 15:731-5. 2005....
- Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumptionCarmen Lilla
Division of Clinical Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 15:99-107. 2006N-Acetyltransferases 1 and 2 (NAT1 and NAT2), both being highly polymorphic, are involved in the metabolism of aromatic and heterocyclic aromatic amines present in cigarette smoke and red meat cooked by high-temperature cooking techniques...
- The influence of various genotypes on the metabolic activity of NAT2 in a Chinese populationBing Chen
Department of Pharmacy, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People s Republic of China
Eur J Clin Pharmacol 62:355-9. 2006To determine the phenotype and genotype of NAT2 in a Chinese population and study the influence of various NAT2 genotypes on the NAT2 activity.
- Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and genetic polymorphisms in breast cancer patientsHsien Wen Kuo
Institute of Environmental Health, China Medical University, No 91, Hsueh Shin Road, Taichung, Taiwan
Mutat Res 631:62-8. 2007..However, it was found that breast cancer was not significantly influenced by CYP1A1, CYP1M1 or NAT2 polymorphisms...
- NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in TaiwanChi Chou Huang
Colorectal Division, Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan, Republic of China
Dis Colon Rectum 50:981-9. 2007..Heterocyclic amines from dietary cooked meats are metabolically activated by NAT2 (N-acetyltransferase 2), which are associated with colorectal cancer incidence...
- Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinomaSuhal S Mahid
Price Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA
BMC Med Genet 8:28. 2007N-acetyltransferase 1 (NAT1) and 2 (NAT2) are polymorphic isoenzymes responsible for the metabolism of numerous drugs and carcinogens...
- Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesisSimon Sanderson
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
Am J Epidemiol 166:741-51. 2007..review and evidence synthesis, the authors investigated the joint effects of the N-acetyltransferase genes NAT1 and NAT2 and cigarette smoking on bladder carcinogenesis...
- Prospective study of NAT1 and NAT2 polymorphisms, tobacco smoking and meat consumption and risk of colorectal cancerMette Sørensen
Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
Cancer Lett 266:186-93. 2008Heterocyclic amines in tobacco smoke and fried meat are activated or detoxified by N-acetyltransferases (NAT1 and NAT2). We identified 379 cases with colorectal cancer (CRC) and 769 sub-cohort members among a cohort of 57,000 members...
- Prospective study of the association between NAT2 gene haplotypes and severe adverse events with sulfasalazine therapy in patients with rheumatoid arthritisMakoto Soejima
J Rheumatol 35:724. 2008
- Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: a hospital-based case-control study in JapanMinatsu Kobayashi
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
Scand J Gastroenterol 44:952-9. 2009..A further objective was to investigate the possible effect of genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on colorectal cancer.
- Sequence analysis of NAT2 gene in Brazilians: identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structureRaquel L F Teixeira
Laboratory of Human Genetics, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
Mutat Res 683:43-9. 2010N-Acetyltransferase 2 (NAT2) metabolizes a variety of xenobiotics that includes many drugs, chemicals and carcinogens...
- Phenotyping with sulfasalazine - time dependence and relation to NAT2 pharmacogeneticsU D Kuhn
Institute for Pharmacology and Toxicology, Division of Clinical Pharmacology, Medical Faculty Friedrich Schiller University Jena, Dornburger Strasse 159, 07740 Jena, Germany
Int J Clin Pharmacol Ther 48:1-10. 2010N-acetyltransferase 2 (NAT2) genotype-phenotype relation with sulfasalazine as probe drug by means of detailed genotype analysis and kinetic data evaluation.
- NAT2 polymorphism and lung cancer risk: a meta-analysisDan Cui
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 450001 Zhengzhou, China
Lung Cancer 73:153-7. 2011N-acetyltransferase 2 (NAT2) gene encodes a key enzyme involved in the metabolism of xenobiotics and whose polymorphisms have been related to individual susceptibility to several malignancies...
- NAT2 and CYP2E1 polymorphisms associated with antituberculosis drug-induced hepatotoxicity in Chinese patientsHui ru An
Institute of Tuberculosis Research, 309th Hospital of Chinese People s Liberation Army, Beijing, China
Clin Exp Pharmacol Physiol 39:535-43. 2012..of two important drug-metabolizing enzymes involved in the metabolism of isoniazid, namely N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1). 2...
- Diverse point mutations in the human gene for polymorphic N-acetyltransferaseK P Vatsis
Department of Pharmacology, Medical School, University of Michigan, Ann Arbor 48109 0626
Proc Natl Acad Sci U S A 88:6333-7. 1991..3.1.5), NAT1 and NAT2, presumably code for the genetically invariant and variant NAT proteins, respectively...
- Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, blacks, Hispanics, and whites: application to metabolic epidemiologyH J Lin
Department of Pediatrics, Harbor UCLA Medical Center, Torrance 90502
Am J Hum Genet 52:827-34. 1993..determine the population frequencies of the major slow acetylator alleles of the polymorphic N-acetyltransferase (NAT2) gene, whose locus maps to chromosome 8...
- Allelic polymorphism of GSTM1 and NAT2 genes modifies dietary-induced DNA damage in colorectal mucosaI Kiss
Department of Public Health, Medical Faculty, University of Sciences Pécs, Hungary
Eur J Cancer Prev 9:429-32. 2000..Our study emphasizes the importance of using susceptibility markers in cancer epidemiology, since environmental effects are strongly modified by these genetic factors...
- Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer riskL Le Marchand
Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
Cancer Epidemiol Biomarkers Prev 10:1259-66. 2001..increases the risk of colorectal cancer (CRC), especially in individuals with the rapid phenotype for CYP1A2 and NAT2. This association may be particularly strong in smokers because smoking is known to induce CYP1A2...
- N-acetyltransferase 2 polymorphism in sporadic Parkinson's disease in a Polish populationMonika Bialecka
Department of Pharmacology, Pomeranian Academy of Medicine, Szczecin, Poland
Eur J Clin Pharmacol 57:857-62. 2002..This study was carried out to determine the presence of N-acetyltransferase 2 polymorphism in Parkinson's disease patients in a Polish population...
- The role of N-acetyltransferase-2 and glutathione S-transferase on the risk and aggressiveness of bladder cancerXenofon Giannakopoulos
Department of Urology Laboratory of Molecular Urology, Ioannina University School of Medicine, 451 10 Ioannina, Greece
Anticancer Res 22:3801-4. 2002..Studies that will simultaneously examine the role of several genetic and environmental factors involved in bladder carcinogenesis are needed to give a global picture for the risk factors of bladder cancer and their potential interaction...
- Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's diseaseJ M van der Walt
Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
Neurology 60:1189-91. 2003..linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single ..
- Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFRGail McKeown-Eyssen
Departments of Public Health Sciences, University of Toronto, ON, Canada
Int J Epidemiol 33:971-8. 2004..Because genetic variation alters the rate of chemical metabolism, this study was designed to determine if MCS cases differed from controls for genetic polymorphisms in drug-metabolizing enzymes...
- Effects of N-acetyl transferase 1 and 2 polymorphisms on bladder cancer risk in CaucasiansJian Gu
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Mutat Res 581:97-104. 2005..Two distinct N-acetyl transferase (NAT) enzymes, NAT1 and NAT2, play important roles in the bio-activation and detoxification of these carcinogens...
- Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2Yu Zang
Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292, USA
Carcinogenesis 28:1665-71. 2007Human N-acetyltransferase 2 (NAT2) is polymorphic in humans and may associate with cancer risk by modifying individual susceptibility to cancers from carcinogen exposure...
- A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility lociNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Nat Genet 42:978-84. 2010..3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions...
- Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liverS Ohsako
Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neurosciences, Japan
J Biol Chem 265:4630-4. 1990....
- Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expressionM Blum
Department of Pharmacology, University of Basel, Switzerland
DNA Cell Biol 9:193-203. 1990..None of the three genomic coding sequences was interrupted by introns. Two genes, designated NAT1 and NAT2, each possessed open reading frames of 870 bp. Both genes have been assigned to human chromosome 8, pter-q11...
- Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylationD M Grant
Department of Pharmacology, University of Basel, Switzerland
Nucleic Acids Res 17:3978. 1989
- N-acetyltransferase polymorphisms and colorectal cancer: a HuGE reviewN Brockton
Department of Medicine and Therapeutics, University of Aberdeen, Scotland, United Kingdom
Am J Epidemiol 151:846-61. 2000The two expressed genes coding for N-acetyltransferase (NAT) activity, NAT1 and NAT2, are located on chromosome 8 at 8p21.3-23.1 and are polymorphic...
- Cytochrome P4501A2 (CYP1A2) activity and lung cancer risk: a preliminary study among Chinese women in SingaporeA Seow
Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive, MD3, 117597, Singapore
Carcinogenesis 22:673-7. 2001..Hepatic CYP1A2 and NAT2 are involved in the metabolism of carcinogenic arylamines, and NAT2 also catalyzes the detoxification pathway for ..
- Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancerPervez F Firozi
Department of Gastrointestinal Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Carcinogenesis 23:301-6. 2002..breast tissues and polymorphisms of the drug-metabolizing genes cytochrome P4501A1 (CYP1A1), N-acetyltransferase-2 (NAT2), and glutathione S-transferase M1 (GSTM1), in 166 women having breast cancer...
- [Relationship between polymorphism of N-acetyltransferase 2 and genetic susceptibility to laryngeal carcinoma]Dapeng Lei
Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Jinan 250012, China
Zhonghua Zhong Liu Za Zhi 24:154-6. 2002To investigate the relationship between polymorphism of N-acetyltransferase (NAT2) gene and genetic susceptibility to laryngeal carcinoma.
- Differences in N-acetylation genotypes between Caucasians and Black South Africans: implications for cancer preventionAlexandre Loktionov
Dunn Human Nutrition Unit, MRC Wellcome Trust, Cambridge, UK
Cancer Detect Prev 26:15-22. 2002Polymorphic N-acetyltransferase genes (NAT1 and NAT2) determine rapid or slow acetylation phenotypes, which are believed to affect cancer risk related to environmental exposure...
- N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitisElena Ricart
Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
Am J Gastroenterol 97:1763-8. 2002..mucosa by N-acetyltransferase 1 (NAT1), and sulfapyridine is metabolized in the liver by N-acetyltransferase 2 (NAT2). Common genetic polymorphisms in these enzymes result in rapid and slow acetylation...
- Differential effect of NAT2 on the association between active and passive smoke exposure and breast cancer riskJenny Chang-Claude
Division of Clinical Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 11:698-704. 2002Polymorphisms in the N-acetyltransferase 2 (NAT2) gene influence the rate of metabolism of aromatic and heterocyclic amines present in tobacco smoke...
- Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitisYi Shin Huang
Division of Gastroenterology, Department of Medicine, and the Chest Department, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
Hepatology 37:924-30. 2003..Their CYP2E1 and NAT2 genotypes were determined using a polymerase chain reaction with restriction fragment length polymorphism method...
- Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR-1 in the Egyptian populationSamar I Hamdy
Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan, and Faculty of Pharmacy, Cairo University, Egypt
Br J Clin Pharmacol 55:560-9. 2003The goal of this study was to determine the frequencies of important allelic variants in the TPMT, NAT2, GST, SULT1A1 and MDR-1 genes in the Egyptian population and compare them with the frequencies in other ethnic populations.
- Polymorphism of the N-acetyltransferase 2 gene, red meat intake, and the susceptibility of hepatocellular carcinomaYi Shin Huang
Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
Am J Gastroenterol 98:1417-22. 2003..The aim of this study was to evaluate the relationship of NAT2 genetic polymorphisms with hepatocellular carcinoma (HCC), with special reference to the interaction of dietary ..
- N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosusGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
J Rheumatol 31:76-80. 2004To examine the association between N-acetyl transferase (NAT) genotype (NAT1 and NAT2) and risk of developing systemic lupus erythematosus (SLE).
- Risk of colorectal adenomas in relation to meat consumption, meat preparation, and genetic susceptibility in a Dutch populationEdine W Tiemersma
Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, The Netherlands
Cancer Causes Control 15:225-36. 2004..We studied the association between meat consumption and colorectal adenomas, and potential influence of genetic susceptibility to heterocyclic aromatic amines (HCAs) formed during meat cooking at high temperatures...
- NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variantNichola Johnson
University Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
BMC Med Genet 5:6. 2004..The purpose of this study was to determine whether polymorphisms in the human NAT genes influence susceptibility to Alzheimer's disease...
- The influence of human N-acetyltransferase genotype on the early bactericidal activity of isoniazidP R Donald
Department of Paediatrics and Child Health, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
Clin Infect Dis 39:1425-30. 2004The elimination of isoniazid is subject to the influence of the N-acetyltransferase 2 (NAT2) genotype, and individuals may be homozygotic slow, heterozygotic fast, or homozygotic fast acetylators of isoniazid...
- NAT2 slow acetylator genotype as an important modifier of breast cancer riskPia Sillanpää
Finnish Institute of Occupational Health, Helsinki, Finland
Int J Cancer 114:579-84. 2005N-acetyltransferase 2 (NAT2) is a polymorphic enzyme participating in the metabolism of numerous pharmaceutical drugs and carcinogens found in tobacco smoke and diet...
- Activating liver carcinogens in yeast by expressing CYP450 polymorphismsMichael Fasullo; Fiscal Year: 2007..Heterocyclic aromatic amines (HAs) require additional activation by N,O- acetyltransferase (NAT2)...
- Genetic polymorphisms in 5'-UTR of human NAT1 and NAT2Anwar Husain; Fiscal Year: 2006DESCRIPTION (provided by applicant): This project will characterize the minimal promoter region of human NAT1 and NAT2 and study effects of genetic polymorphisms on expression in human mammary cells...
- ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISMStephen Schwartz; Fiscal Year: 2001..EPHX), cytochrome p450 2E1 (CYP2E1), alcohol dehydrogenase type 3 (ADH3), N-acetyltransferase types 1 and 2 (NAT1, NAT2), and NAD(P)H:quinone oxidoreductase (NQ01)...
- RACHEL FYNVOLA TYNDALE; Fiscal Year: 2014..The goal of the Pharmacogenetics of Nicotine Addiction Treatment (PNAT) research program is to generate the evidence base to optimize treatment decisions for Individuals who want to quit ..
- Activating liver carcinogens in yeast by expressing CYP450 polymorphismsMICHAEL THOMAS FASULLO; Fiscal Year: 2010..Heterocyclic aromatic amines (HAs) require additional activation by N,O-acetyltransferase (NAT2)...
- Gregory P Bisson; Fiscal Year: 2014..aspect of this proposal is that both aims will take into account variability in the N- acetyltransferase 2 (NAT2) allele, which is a major determinant of INH CL...
- GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICEDaniel Nebert; Fiscal Year: 2002..causes bladder ABP-DNA adducts and tumor formation as the consequence of hepatic CYP1A2 and N-acetyltransferase (NAT2) levels, as well as urinary pH...
- Pharmacogenetics of sulfamethoxazole in HIV/AIDS patientsDanxin Wang; Fiscal Year: 2009..Several pathways determine SMX hypersensitivity: Metabolic inactivation by N-acetyltransferases 1 and 2 (NAT1 and NAT2);metabolic oxidation to toxic hydroxylamine derivatives by CYP2C9 and other (extra-) hepatic enzymes;protection ..
- GENE-ENVIRONMENT EFFECTS AND COLON ADENOMASHenry Lin; Fiscal Year: 2000..The project will characterize polymorphic genes for NAT1, NAT2, GSTM1, GSTM3, GSTT1, PGHS-1, PGHS-2, and cPLA2 in all subjects...
- Molecular Analysis of the Mitochondrial ADP/ATP Carrier Protein ComplexesRosemary Stuart; Fiscal Year: 2009..of adPEO is characterized by a loss of COX activity and modeling of the disease in yeast using the hANT1 ortholog, AAC2, has indicated that it is the structural presence of a mutated AAC family member, rather than a compromised ..
- RISK FACTORS AND BIOMARKERS FOR IN SITU BREAST CANCERLinda Titus Ernstoff; Fiscal Year: 1999..to evaluate the relationship between BCIS (and its subtypes) to p53 mutations, HER-2/neu amplifications, and NAT2 genotype...
- Diet, gene-diet interactions and risk of Parkinson'sHonglei Chen; Fiscal Year: 2004..In the HPFS and NHS cohorts, he will evaluate the associations of PD risk with common polymorphisms of NAT2, CYP1A2, ADH2, ADH3, ADH4, and MTHFR...
- IDENTIFYING MODIFYING GENES IN BRCA1 MUTATION CARRIERSKatherine Nathanson; Fiscal Year: 2005..is preliminary data from several association studies, looking at HRAS, APC, the androgen receptor, AIB1, hRad51 and NAT2, which demonstrate that certain alleles of these genes modify penetrance in BRCA1 mutation carriers...
- PHARMACOGENETIC DETERMINANTS OF FETAL SOMATIC MUTATIONMarjorie Romkes; Fiscal Year: 2002..in the metabolism of chemicals found in cigarette smoke, specifically CYP1A1, CYP2E1, GSTM1, GSTT1, NAT1*, and NAT2*...
- Acetylator-based Individualized Dosing of AmonadifeJohn Lister James; Fiscal Year: 2005..In our phase I proposal, we developed a rapid method for NAT2 phenotyping...
- Gene-Environment Interactions in RA Autoimmunity and Disease SeverityTed Mikuls; Fiscal Year: 2009..to SE, genetic factors to be studied will include DME polymorphisms (in genes encoding N-acetyltransferase [NAT]1, NAT2, microsomal epoxide hydrolase, and glutathione S-transferase), and protein tyrosine phosphatase (PTPN22)...
- Population Study of Rectal Cancer in Blacks and WhitesRobert Sandler; Fiscal Year: 2005..The study will focus on the known alleles of the N-acetyltransferase genes (NAT1 and NAT2) and manganese superoxide dismutase (MnSOD) genes using DNA obtained from blood samples...
- Comprehensive Assessment of Bladder Cancer Genetic SusceptibilityAngeline Andrew; Fiscal Year: 2007..g., NAT2). However, results for a number of polymorphisms are inconsistent...
- Microarray-based genotyping for studying susceptibility to mesotheliomaStefano Landi; Fiscal Year: 2007..For example, previous studies showed a higher risk for people with GSTM1 null genotype and NAT2 slow acetylators The aim of the present project is to dissect the influence of genes in the etiology of this ..
- COHORT STUDY OF GENETIC MARKERS IN COLON CANCERDavid Hunter; Fiscal Year: 2005..They hypothesize that "fast acetylator" NAT2 genotype, a recently described defect in NAT1, homozygous deletions in the GSTM1 gene, and the "extensive ..
- Using Tobacco Biomarkers to Improve Smoking Cessation RatesStephen Wilson; Fiscal Year: 2009..differences in DNA adducts, we will explore whether polymorphisms in 4 candidate genes (GSTM1, GSTT1, GSTP1, and NAT2) modify the relationship between African American race and WBC DNA adducts...
- Gene-gene interaction in nasopharyngeal carcinomaYIN YAO; Fiscal Year: 2005..of 5 CYP genes (CYP1A1, CYP1A2, CYP2D6, CYP2E1, CYP1B1) and a few other polymorphisms (GSTM1, GSTT1, NQO1, NAT1 and NAT2) contribute to the development of NPC and to test for the interaction with high risk genotypes and modifiable risk ..
- PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISMDavid Hein; Fiscal Year: 2009..breast cancer in those individuals with rapid and/or slow acetylator N-acetyltransferase- 1 (NAT1) and - 2 (NAT2) acetylator genotypes...
- GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSBrian Henderson; Fiscal Year: 2000..Specifically, this proposal will investigate polymorphisms in candidate genes (NAT2, GSTM1, CYP1A1, SRD5A2, AR, EDH17B2, CYP17, and ER), that might alter metabolism of relevant endogenous or ..
- Molecular Genetics of NAT1 and NAT2 in Prostate CancerNicholas Lang; Fiscal Year: 2005..Our preliminary data has shown that elevated NAT2 enzyme activity is strongly associated with increased risk of prostate cancer in both Caucasian and African-..
- GENE-ENVIRONMENT INTERACTIONS: THE ODYSSEY COHORTSandra Hoffman; Fiscal Year: 2003..hormones (MTHFR, VDR, CYP17, CYP1B1, COMT, CYP3A4 ); 2) metabolize carcinogens (ADH, GSTM1, GSTT1, GSTP1, NAT1 and NAT2, NOS, CYP1A1, CYP1B1, EH); and 3) control DNA repair processes (XRCC1, XRCC3, XPD)...
- Urinary proteomics in aminoglycoside treated newbornsMary Kennedy; Fiscal Year: 2008..The results of this research may allow us to identify infants who are at risk for developing significant injury before it occurs. [unreadable] [unreadable] [unreadable]..
- Molecular Epidemiology of Pancreatic CancerDonghui Li; Fiscal Year: 2008..e. CYP1A2, CYP1B1, CYP2E1, NAT1, NAT2, SUL1A1, UGT1A1 and GSTT1, and a DNA repair gene, XRCCI...
- Pediatric Asthma, Particulate Air Pollution and NO2RALPH DELFINO; Fiscal Year: 2006..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
- ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUTRALPH DELFINO; Fiscal Year: 2001..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
- Colonoscopic Analysis of Response of Murine Colon Lesions to Drug Intervention MARGIE CLAPPER; Fiscal Year: 2008..These results could lead to the establishment of the first accepted therapy for the prevention of colon cancer. [unreadable] [unreadable] [unreadable]..
- UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal WomenJohanna Lampe; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Ethnic/Racial Minorities in the Colon CFRLoic Le Marchand; Fiscal Year: 2008..abstract_text> ..
- GENETIC LINKAGE IN COLORECTAL CANCER FAMILESEllen Goode; Fiscal Year: 2008..A key future aim is to combine these families with those of other CRC linkage studies in the US and UK to amass an extensive resource with further increased power to understand CRC genetic susceptibility. ..
- Conotruncal defects: genetic and nutritional riskEDWARD JAMES LAMMER; Fiscal Year: 2010....
- Genetic Studies of Clubfoot (ITEV)Jacqueline T Hecht; Fiscal Year: 2010..Identification of high-risk genotypes can lead to the development of prevention programs in selected populations and may suggest gene-based prevention strategies. ..
- Dietary Factors in the Etiology of Colorectal CancerJian Min Yuan; Fiscal Year: 2008..Several enzymes that are encoded by cytochrome P4501A2 (CYP1A2), N-acetyltransferase 2 (NAT2) and possibly NAT1 are involved in this HAA activating pathway...
- Lung cancer molecular markers by sex: intergroup studyChristine Ambrosone; Fiscal Year: 2008..Results from this study, the largest to date to evaluate biomarkers of susceptibility and effect, will likely elucidate reasons for the rise in lung cancer, particularly adenocarcinomas, in smoking and non-smoking women. ..
- Serum IGFs--Effects of a Soy Intervention in HumansJohanna Lampe; Fiscal Year: 2002..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
- ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMESChu Chen; Fiscal Year: 2010..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
- Novel approach to measure DNA adducts in humansROBERT TURESKY; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Human Gut Microflora Profiling for Population StudiesJohanna Lampe; Fiscal Year: 2006..abstract_text> ..
- A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANSMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
- Growth Factors and Colon CancerMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
- FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDYMARTHA OR MARTY SLATTERY; Fiscal Year: 2003..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
- P-glycoprotein and Steroid-Resistant Nephrotic SyndromeLYNDA WELAGE; Fiscal Year: 2005..abstract_text> ..
- HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCEJohanna Lampe; Fiscal Year: 2002..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
- Hormone Status Postmenopause: Colonic Bacterial EffectsJohanna Lampe; Fiscal Year: 2003..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
- Modification of tamoxifen effectiveness by gene polymorphisms and other drugsTimothy Lash; Fiscal Year: 2009..Understanding the modification of tamoxifen effectiveness by genetic polymorphisms or drug interactions will help patients and physicians to make fully informed decisions about hormone therapy. ..
- Hawaii Colorectal Cancer Family RegistryLoic Le Marchand; Fiscal Year: 2008..We will also propose a CFR pilot study exploring the feasibility of assessing assorted mating as evidence for population stratification. ..
- Pharmacogenetics: Breast Cancer Treatment and PrognosisChristine Ambrosone; Fiscal Year: 2005..Individualized dosing according to genotype could contribute to increased efficacy and decreased toxicity among patients being treated for cancer. ..
- Antioxidant supplements, genetics, and chemotherapy outcomesChristine Ambrosone; Fiscal Year: 2009....
- Metabolism and Pharmacogenetics in MDMA-Induced ToxicityRafael de la Torre; Fiscal Year: 2009..A study will compare MDMA toxicity when co-adminsitered with the MRP1 inhibitor probenecid. ..
- COMMUNITY BASED STUDY ON OCCUPATIONAL ASTHMA, ECRHS-OAManolis Kogevinas; Fiscal Year: 2001..abstract_text> ..
- Cancer Incidence among Transplant Recipients:1990-2001LESLEY BUTLER; Fiscal Year: 2004..abstract_text> ..
- DNA Damage: Fruit & Vegetable Effects in a Feeding TrialJohanna Lampe; Fiscal Year: 2005..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
- CYP1A1 GENE AND ENVIRONMENTAL TOXICITYDaniel Nebert; Fiscal Year: 2005..abstract_text> ..
- GENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERSLoic Le Marchand; Fiscal Year: 2004..The elucidation of the main enzymes responsible for carcinogen activation and of the impact of dietary factors on these enzymes would have important implications for cancer prevention. ..
- THE SINGAPORE COHORT STUDY OF DIET AND CANCERJian Min Yuan; Fiscal Year: 2009....
- MOLECULAR EPIDEMIOLOGY OF LUNG CANCERChu Chen; Fiscal Year: 2010..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
- BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMENChu Chen; Fiscal Year: 2003..Our ultimate goal is to provide information to identify women at high risk of breast cancer, and to aid in the formulation of prevention strategies for these women. ..
- GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCESJohanna Lampe; Fiscal Year: 2006..abstract_text> ..
- Disruption of Glutathione S-Transferase M1 in MiceMARGIE CLAPPER; Fiscal Year: 2006..abstract_text> ..
- Molecular Epidemiology of Endometrial CancerChu Chen; Fiscal Year: 2007..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
- Diet, Genetic Susceptibility and Colorectal NeoplasiaLoic Le Marchand; Fiscal Year: 2006..Genotyping for random markers will permit to exclude residual confounding by ethnicity. ..
- DIETARY FACTORS IN THE ETIOLOGY OF CANCER IN SHANGHAIJian Min Yuan; Fiscal Year: 2006..In all instances of diet-cancer investigations, relevant genes with potential modifying effects on the respective diet-cancer associations will be included in the investigations. ..
- Breast and Bone Density: Impact of Colonic EnvironmentJohanna Lampe; Fiscal Year: 2006..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
- Aspirin, UGT1A6 Genotype, and Colon Gene ExpressionJohanna Lampe; Fiscal Year: 2006..By targeting relevant pathways, side effects caused by the use of NSAIDs or specific Cox-2 inhibitors may be avoided. ..
- Case-Control Study of Adenoma in Sao Paulo JapaneseLoic Le Marchand; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Crystallographic Analysis of GHMP kinasesHong Zhang; Fiscal Year: 2005....
- Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese WomenJohanna Lampe; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Synergism of Gene and Environment in Cancer Studies: A New Bayesian ApproachBhramar Mukherjee; Fiscal Year: 2008..The methods developed may be routinely applied to various epidemiological studies of gene-environment interaction. [unreadable] [unreadable] [unreadable] [unreadable]..
- RA Comorbidity Bone Health in Men and African AmericansTed Mikuls; Fiscal Year: 2008..Mikuls' continued development as an independent clinical investigator. ..
- The TGFbeta Pathway, Gene Variants and Colorectal Neopl*Loic Le Marchand; Fiscal Year: 2005..abstract_text> ..
- Seattle Colorectal Cancer Family Registry (CFR)Polly Newcomb; Fiscal Year: 2007..The CCFR - S provides an important\par population-based perspective within our consortium studies of colorectal cancer.\fs20\par \par } ..
- Risk Factors for Molecularly Defined Subgroups of Lymphoma: A Pooled AnalysisBrian Chiu; Fiscal Year: 2008..This project directly responds to the NCI strategic plan for cancer preemption because it can elucidate the etiology of NHL. [unreadable] [unreadable] [unreadable]..
- Race & Risk Factors for Early/Aggressive Breast CancerChristine Ambrosone; Fiscal Year: 2008..Results from this study will provide much-needed answers as to why African-American women are more likely than Caucasians to be diagnosed with more aggressive disease at an earlier age. ..