NAT2

Summary

Gene Symbol: NAT2
Description: N-acetyltransferase 2
Alias: AAC2, NAT-2, PNAT, arylamine N-acetyltransferase 2, N-acetyltransferase 2 (arylamine N-acetyltransferase), N-acetyltransferase type 2, arylamide acetylase 2
Species: human

Top Publications

  1. ncbi A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer
    Heather M Ochs-Balcom
    Department of Epidemiology and Biostatistics, Case Western Reserve University, and Ireland Comprehensive Cancer Center at University Hospitals of Cleveland, OH 44106 7281, USA
    Am J Epidemiol 166:246-54. 2007
  2. pmc NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
    Lancet 366:649-59. 2005
  3. ncbi [A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer]
    Kun Chen
    Departent of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310031, China
    Zhonghua Liu Xing Bing Xue Za Zhi 26:659-64. 2005
  4. ncbi Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway
    Halla Skuladottir
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Lung Cancer 48:187-99. 2005
  5. doi Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype
    Silvia Selinski
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Dortmund, Germany
    Pharmacogenet Genomics 21:673-8. 2011
  6. ncbi Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking
    Kana Yoshida
    Faculty of Health Sciences, Kobe University Graduate School of Medicine, 7 10 2 Tomogaoka, Sumaku, Kobe 654 0142, Japan
    Asian Pac J Cancer Prev 8:438-44. 2007
  7. pmc Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk
    Michelle Cotterchio
    Population Studies and Surveillance, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada, M5G 2L7
    Cancer Epidemiol Biomarkers Prev 17:3098-107. 2008
  8. pmc Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study
    Lesley M Butler
    University of California Davis, Department of Public Health Sciences, Division of Epidemiology, Davis, CA 95616, USA
    Mutat Res 638:162-74. 2008
  9. ncbi Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer
    Istvan Kiss
    Department of Public Health, Faculty of Medicine, Pécs University of Sciences, Pecs, Hungary
    Anticancer Res 24:3965-70. 2004
  10. doi Sequence variants of NAT1 and NAT2 and other xenometabolic genes and risk of lung and aerodigestive tract cancers in Central Europe
    James D McKay
    Association for International Cancer Research, 150 cours Albert Thomas, Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 17:141-7. 2008

Research Grants

  1. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    Michael Fasullo; Fiscal Year: 2007
  2. Genetic polymorphisms in 5'-UTR of human NAT1 and NAT2
    Anwar Husain; Fiscal Year: 2006
  3. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2001
  4. RACHEL FYNVOLA TYNDALE; Fiscal Year: 2014
  5. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
  6. Gregory P Bisson; Fiscal Year: 2014
  7. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
  8. Pharmacogenetics of sulfamethoxazole in HIV/AIDS patients
    Danxin Wang; Fiscal Year: 2009
  9. GENE-ENVIRONMENT EFFECTS AND COLON ADENOMAS
    Henry Lin; Fiscal Year: 2000
  10. Molecular Analysis of the Mitochondrial ADP/ATP Carrier Protein Complexes
    Rosemary Stuart; Fiscal Year: 2009

Detail Information

Publications267 found, 100 shown here

  1. ncbi A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer
    Heather M Ochs-Balcom
    Department of Epidemiology and Biostatistics, Case Western Reserve University, and Ireland Comprehensive Cancer Center at University Hospitals of Cleveland, OH 44106 7281, USA
    Am J Epidemiol 166:246-54. 2007
    The N-acetyltransferase 2 gene (NAT2) product is an enzyme important in carcinogen metabolism via activation and detoxification pathways. Therefore, NAT2 variants may represent underlying susceptibility to breast cancer...
  2. pmc NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
    Lancet 366:649-59. 2005
    ..An exception could be the association between NAT2 slow acetylation, GSTM1 null genotype, and bladder-cancer risk...
  3. ncbi [A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer]
    Kun Chen
    Departent of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310031, China
    Zhonghua Liu Xing Bing Xue Za Zhi 26:659-64. 2005
    ..To investigate the association between metabolic enzymes polymorphisms and the risk of colorectal cancer(CRC)...
  4. ncbi Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway
    Halla Skuladottir
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Lung Cancer 48:187-99. 2005
    ..and polymorphisms in following genotypes were determined GSTM1, GSTM3, GSTP1, GSTT1, GPX1, MPO, NQO1 and NAT2. Based on the literature, the alleles of the genotypes were categorised as high- or low-risk alleles...
  5. doi Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype
    Silvia Selinski
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Dortmund, Germany
    Pharmacogenet Genomics 21:673-8. 2011
    Genotyping N-acetyltransferase 2 (NAT2) is of high relevance for individualized dosing of antituberculosis drugs and bladder cancer epidemiology...
  6. ncbi Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking
    Kana Yoshida
    Faculty of Health Sciences, Kobe University Graduate School of Medicine, 7 10 2 Tomogaoka, Sumaku, Kobe 654 0142, Japan
    Asian Pac J Cancer Prev 8:438-44. 2007
    We investigated CYP1A1*2A, CYP1A1*2C, CYP1A2*1C, CYP1A2*1F, GSTM1 and NAT2 gene polymorphisms, involving enzymes which metabolize many carcinogens, with reference to colorectal cancer risk...
  7. pmc Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk
    Michelle Cotterchio
    Population Studies and Surveillance, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada, M5G 2L7
    Cancer Epidemiol Biomarkers Prev 17:3098-107. 2008
    ..CYP2C9 and NAT2 variants were associated with colorectal cancer risk...
  8. pmc Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study
    Lesley M Butler
    University of California Davis, Department of Public Health Sciences, Division of Epidemiology, Davis, CA 95616, USA
    Mutat Res 638:162-74. 2008
    ..We examined whether our previously reported associations between meat-derived heterocyclic amine (HCA) intake and colon cancer were modified by N-acetyltransferase 1 (NAT1) or 2 (NAT2) genotypes and whether there were differences by race.
  9. ncbi Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer
    Istvan Kiss
    Department of Public Health, Faculty of Medicine, Pécs University of Sciences, Pecs, Hungary
    Anticancer Res 24:3965-70. 2004
    ..We evaluated the effect of GSTM1, GSTT1, GSTP1, NAT1 and NAT2 enzymes on individual susceptibility to colorectal cancer, with particular attention to possible interactions ..
  10. doi Sequence variants of NAT1 and NAT2 and other xenometabolic genes and risk of lung and aerodigestive tract cancers in Central Europe
    James D McKay
    Association for International Cancer Research, 150 cours Albert Thomas, Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 17:141-7. 2008
    ..78; 95%CI, 0.65-0.95). In NAT2, when considering the individuals inferred acetylator phenotypes based on their NAT2 diplotype, "slow" acetylators ..
  11. ncbi Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology and Genetics, School of Biological Sciences, University of Extremadura, Avda de Elvas s n, E 06071, Badajoz, Spain
    Curr Drug Metab 9:487-97. 2008
    Genetic polymorphisms of human arylamine N-acetyltransferase 2 (NAT2) are responsible for interindividual variation in the acetylation of numerous drugs and in the transformation of aromatic and heterocyclic amines into carcinogenic ..
  12. ncbi The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies
    K F Windmill
    Department of Physiology and Pharmacology, University of Queensland, Brisbone, Australia
    Mutat Res 376:153-60. 1997
    ..metabolism can involve both N, O-acetylation and N, O-sulfonation catalyzed by N-acetyltransferases (NAT1 and NAT2) and sulfotransferases, respectively...
  13. pmc Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study
    Ute Nöthlings
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 18:2098-106. 2009
    ..We investigated the modifying effects of NAT1 and NAT2 polymorphisms on the association of meat consumption, heterocyclic amine intake, and smoking with colorectal cancer ..
  14. pmc Association of polymorphism in cytochrome P450 2D6 and N-acetyltransferase-2 with Parkinson's disease
    Madhu Singh
    Developmental Toxicology Division, Indian Institute of Toxicology Research formerly Industrial Toxicology Research Centre, CSIR, PO Box 80, MG Marg, Lucknow 226 001, India
    Dis Markers 28:87-93. 2010
    ..out to investigate the association of polymorphism in cytochrome P450 2D6 (CYP2D6) and N-acteyltransferase-2 (NAT2}, that are involved in the metabolism and detoxification of chemicals causing Parkinson disease (PD) like symptoms, ..
  15. ncbi Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol
    J W Rodriguez
    Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, GA 30310
    Arch Toxicol 67:445-52. 1993
    ..e., approximately 25% Black and 75% White). The polymorphic N-acetyltransferase gene (NAT2) was amplified by the polymerase chain reaction from DNA templates derived from human colons of colorectal and non-..
  16. ncbi Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans
    D A Bell
    Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Carcinogenesis 14:1689-92. 1993
    ..The presence of two germline copies of any of several mutant alleles of the NAT2 gene produces a slow-acetylation phenotype...
  17. pmc Chromosomal localization of human genes for arylamine N-acetyltransferase
    D Hickman
    MRC Human Biochemical Genetics Unit UCL, Galton Laboratory, London, U K
    Biochem J 297:441-5. 1994
    ..The hybridization patterns allow assignment of AAC-1 and AAC-2 to chromosome 8p21.3-23.1, a region in which deletions have been associated with bladder cancer [Knowles, Shaw and Proctor (1993) Oncogene 8, 1357-1364]...
  18. ncbi Arylamine N-acetyltransferase type 2 and glutathione S-transferases M1 and T1 polymorphisms in familial adenomatous polyposis
    Christof Lamberti
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Pharmacogenetics 12:49-54. 2002
    ..We examined whether the polymorphisms of the NAT2, GSTM1, and GSTT1 enzymes affect age at diagnosis of first colorectal adenomas or extracolonic manifestations in ..
  19. ncbi Strong association between N-acetyltransferase 2 genotype and PD in Hong Kong Chinese
    D K Y Chan
    University of New South Wales, Bankstown Hospital, Bankstown, New South Wales, Australia
    Neurology 60:1002-5. 2003
    The slow acetylator genotype for N-acetyltransferase 2 (NAT2 genotype) may be associated with PD in white subjects and the genotype is common in both white and Chinese populations...
  20. ncbi Re-investigation of the concordance of human NAT2 phenotypes and genotypes
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Ardeystr 67, 44139, Dortmund, Germany
    Arch Toxicol 79:196-200. 2005
    A comparative study of N-acetyltransferase 2 (NAT2) genotyping and phenotyping (caffeine test method) was performed on 211 persons to elucidate apparent discrepancies in the assignment of NAT2*12 and NAT2*13 alleles which occur in the ..
  21. ncbi NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in Taiwan
    Hui Ling Chiou
    School of Medical Technology, Chung Shan Medical University, Taichung, Taiwan, ROC
    Cancer Lett 223:93-101. 2005
    ..The association of genetic polymorphisms of CYP1A2 and NAT2, two major enzymes responsible for the metabolism of heterocyclic amines, with lung cancer has been investigated ..
  22. pmc N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease
    Juergen Borlak
    Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Nikolai Fuchs Strasse 1, 30625 Hannover, Germany
    BMC Med Genet 7:30. 2006
    ..Sequence variations in N-acetyltransferase 2 (NAT2) gene leading to slow acetylation process have been associated with PD, but results are contradictory.
  23. doi NAT2 polymorphism and gastric cancer susceptibility: a meta-analysis
    Xu Zhong
    Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Arch Med Res 41:275-80. 2010
    N-acetyltransferase 2 (NAT2) is a polymorphic enzyme that plays an important role in the metabolism of various potential carcinogens. NAT2 can be subdivided into rapid and slow acetylation phenotype according to the different genotypes...
  24. ncbi Sequences and expression of alleles of polymorphic arylamine N-acetyltransferase of human liver
    T Deguchi
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neurosciences, Japan
    J Biol Chem 267:18140-7. 1992
    ..Expression studies of the alleles in Chinese hamster ovary cells show that allele 1 expresses high levels of N-acetyltransferase activity and enzyme protein, while alleles 2 and 3 express low levels of both protein and activity...
  25. ncbi Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene
    H J Lin
    Department of Pediatrics, Harbor UCLA Medical Center, Torrance 90502
    Pharmacogenetics 4:125-34. 1994
    ..We identified two additional NAT2 mutations, suggesting that other rare alleles are likely to be found.
  26. ncbi Arylamine N-acetyltransferase 2 polymorphism in the ethnic populations of South India
    A Anitha
    Rajiv Gandhi Center for Biotechnology, Poojappura, Trivandrum 695 014, India
    Int J Mol Med 11:125-31. 2003
    ..Acetylation polymorphism arises from the allelic variations in human arylamine N-acetyltransferase 2 gene (NAT2), which results in the production of NAT2 proteins with variable enzyme activity or stability...
  27. ncbi NAT2 slow acetylation and GSTM1 null genotypes may increase postmenopausal breast cancer risk in long-term smoking women
    Olga L van der Hel
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Pharmacogenetics 13:399-407. 2003
    ..However, compared to individuals with rapid NAT2 genotype, women with the very slow acetylator genotype (NAT2*5), who smoked for 20 years showed an increased breast ..
  28. pmc N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulphasalazine in the treatment of inflammatory bowel disease
    Min Chen
    Wuhan University Zhongnan Hospital, Wuhan, People s Republic China
    Can J Gastroenterol 21:155-8. 2007
    N-acetyltransferase 2 (NAT2) is an important enzyme catalyzing N-acetylation of sulfasalazine (SASP)...
  29. ncbi Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review
    S C Cotton
    Department of Medicine and Therapeutics, Faculty of Medicine and Medical Sciences, University of Aberdeen, Scotland
    Am J Epidemiol 151:7-32. 2000
    ..These finding require confirmation. Methods for determining GSTM1 and GSTT1 genotype are well established. Population testing is not currently justified...
  30. ncbi Genetic polymorphisms in N-acetyltransferase-2 and microsomal epoxide hydrolase, cumulative cigarette smoking, and lung cancer
    Wei Zhou
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:15-21. 2002
    N-acetyltrasferase-2 (NAT2) and microsomal epoxide hydrolase (mEH) are polymorphic genes that metabolize different tobacco carcinogens...
  31. pmc Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects
    Alice Matimba
    African Institute of Biomedical Science and Technology AiBST, Harare, Zimbabwe
    Hum Genomics 3:169-90. 2009
    ..The aim of the present study was to search for novel variants of CYP2C9 , CYP2C19 , CYP2D6 and NAT2 genes in Africans, with a particular focus on their prevalence in different populations, their relevance to enzyme ..
  32. ncbi N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast
    J A Williams
    Institute of Cancer Research, Haddow Laboratories, Sutton, UK
    Pharmacogenetics 11:373-88. 2001
    ..Immunohistochemical staining of sections of breast tissue identified expression of NAT1 and NAT2 protein in human mammary epithelial cells, but not in the stroma...
  33. ncbi Metabolic gene polymorphism frequencies in control populations
    S Garte
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Epidemiol Biomarkers Prev 10:1239-48. 2001
    ..genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined...
  34. ncbi N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk
    Harriet Wikman
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 12:227-33. 2002
    ..The NAT2 genotype did not have any significant effect on the risk of developing asthma, but the putative slow acetylator ..
  35. ncbi A slow acetylator genotype associated with an increased risk of advanced cervical cancer
    Sandra Costa
    Unit of Molecular Oncology, Portuguese Institute of Oncology, Laboratórios Piso 4, Rua Dr Bernardino de Almeida, 4200 072 Porto, Portugal
    J Cancer Res Clin Oncol 128:678-82. 2002
    ..N-acetyltransferase 2 (NAT2) has an important role in the metabolism of several carcinogens...
  36. ncbi Variable drug metabolism genes in Arab population
    R Bu
    King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Pharmacogenomics J 4:260-6. 2004
    ..We used PCR analysis to catalog the frequencies of alleles and genotypes for CYP1A1, NAT2, GSTs, MTHFR, MTR (MS) and NQO*1 in Arabs...
  37. ncbi GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population
    Rayjean J Hung
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 110:598-604. 2004
    ..Two N-acetyltransferase isozymes, NAT2 and NAT1, have major roles in catalyzing the N-acetylation and O-acetylation of aromatic amines...
  38. ncbi Arylamine N-acetyltransferase 2 slow acetylator polymorphisms in unrelated Iranian individuals
    Valery V Bakayev
    Department of Pathology, National Research Institute of Tuberculosis and Lung Disease, Shaheed Beheshti University of Medical Sciences and Health Services, Darabad, Tehran, Islamic Republic of Iran
    Eur J Clin Pharmacol 60:467-71. 2004
    To determine the frequency of mutations at the polymorphic gene coding for arylamine N-acetyltransferase 2 (NAT2, EC 2.3.1.5) and NAT2 genotypes associated with slow acetylation in healthy Iranian individuals.
  39. ncbi Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands)
    Olga L van der Hel
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Cancer Causes Control 16:675-81. 2005
    Variants in the metabolic genes NAT1, NAT2, GSTM1 or GSTT1, may cause differences in individual detoxifying capacity of possible carcinogens...
  40. pmc Genetic polymorphism of the N-acetyltransferase 2 gene, and susceptibility to prostate cancer: a pilot study in north Indian population
    Daya S L Srivastava
    Department of Urology Sanjay Gandhi post Graduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
    BMC Urol 5:12. 2005
    ..This study was conducted to examine; (1) whether the N-acetyltransferase 2 (NAT2) genotype is a risk factor for prostate cancer, (2) to study effect of NAT2 genotype on modifying prostate cancer ..
  41. pmc Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene
    Haruhisa Machida
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    World J Gastroenterol 11:4833-7. 2005
    To investigate the frequency and distribution of N-acetyltransferase 2 (NAT2) and uridine 5'-diphosphate (UDP)-glucuronosyltransferase 1A7 (UGT1A7) genes in patients with ulcerative colitis (UC) and Crohn's disease (CD).
  42. ncbi Is the association between cigarette smoking and breast cancer modified by genotype? A review of epidemiologic studies and meta-analysis
    Paul D Terry
    Department of Epidemiology, Emory University School of Public Health, Atlanta, GA 30322, USA
    Cancer Epidemiol Biomarkers Prev 15:602-11. 2006
    ..In particular, 14 epidemiologic studies have tended to show positive associations with long-term smoking among NAT2 slow acetylators, especially among postmenopausal women...
  43. ncbi Basal and induced micronucleus frequencies in human lymphocytes with different GST and NAT2 genetic backgrounds
    Alba Hernandez
    Grup de Mutagenesi, Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Mutat Res 606:12-20. 2006
    ..NAT) genes have been associated with cancer risk, we explored the possible links between GSTM1, GSTP1, GSTT1 and NAT2 variants and the frequency of micronuclei (MN) in human lymphocytes...
  44. pmc Identification of N-acetyltransferase 2 (NAT2) transcription start sites and quantitation of NAT2-specific mRNA in human tissues
    Anwar Husain
    Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Drug Metab Dispos 35:721-7. 2007
    Human N-acetyltransferase 2 (NAT2) genetic polymorphism is associated with drug toxicity and/or carcinogenesis in various tissues. Knowledge of NAT2 gene structure and expression is critical for understanding these associations...
  45. doi Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis
    Christine B Ambrosone
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 17:15-26. 2008
    ..10 years ago, it was noted that smoking increased risk of breast cancer among women with N-acetyltransferase 2 (NAT2) slow acetylation genotypes. This report was followed by a number of studies to address this question...
  46. ncbi Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2
    J M Dupret
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Canada
    J Biol Chem 267:7381-5. 1992
    The single coding exons of the cloned genes encoding two human arylamine N-acetyltransferases (NAT1 and NAT2) were amplified by expression-cassette polymerase chain reaction and subcloned into the tac promoter-based phagemid vector pKEN2 ..
  47. ncbi N-Acetyltransferase-2 genetic polymorphism, well-done meat intake, and breast cancer risk among postmenopausal women
    A C Deitz
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Kentucky 40292, USA
    Cancer Epidemiol Biomarkers Prev 9:905-10. 2000
    ..Polymorphic N-acetyltransferase-2 (NAT2) catalyzes the activation of heterocyclic amines via O-acetylation, suggesting that NAT2 genotypes with high O-..
  48. ncbi N-acetyltransferase 2 (NAT2) genotype and colorectal carcinoma: risk variability according to tumour site?
    - Agúndez JAG
    Dept of Pharmacology, School of Medicine, University of Extremadura, Badajoz, Spain
    Scand J Gastroenterol 35:1087-91. 2000
    ..The polymorphic N-acetyltransferase 2 enzyme (NAT2, E.C. 2.3.1.5) plays a key role in the transformation of HAAs to ultimate carcinogens...
  49. ncbi Analysis of six SNPs of NAT2 in Ngawbe and Embera Amerindians of Panama and determination of the Embera acetylation phenotype using caffeine
    Lucia F Jorge-Nebert
    DNA and Human Genomics Institute, University of Panama, Panama, Republic of Panama
    Pharmacogenetics 12:39-48. 2002
    Six NAT2 single-nucleotide polymorphisms (SNPs) were analysed in 105 unrelated Ngawbe and 136 unrelated Embera Amerindians (482 chromosomes) by SNP-specific polymerase chain reaction analysis...
  50. ncbi Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis
    Yi Shin Huang
    Division of Gastroenterology, Department of Medicine, and Chest Department, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
    Hepatology 35:883-9. 2002
    ..To determine whether acetylator status is a risk factor for antituberculosis drug-induced hepatitis, we genotyped NAT2 in 224 incident tuberculosis patients who received antituberculosis treatment...
  51. ncbi Meat consumption, cigarette smoking, and genetic susceptibility in the etiology of colorectal cancer: results from a Dutch prospective study
    Edine W Tiemersma
    Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
    Cancer Causes Control 13:383-93. 2002
    We evaluated the effect of meat consumption and cigarette smoking in combination with N-acetyltransferases 1 and 2 (NAT1 and NAT2), and glutathione S-transferase M1 (GSTM1) genotypes on colorectal cancer.
  52. ncbi Meta-analysis of 20 case-control studies on the N-acetyltransferase 2 acetylation status and colorectal cancer risk
    Zheng Ye
    Bioinformatics Group, Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea, UK
    Med Sci Monit 8:CR558-65. 2002
    Rapid NAT2 acetylation has been considered as a risk factor for developing colon cancer in a number of studies, however the overall results of such studies are inconsistent...
  53. ncbi Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study
    David W Hein
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Environ Mol Mutagen 40:161-7. 2002
    N-acetyltransferase-1 (NAT1) and N-acetyltransferase-2 (NAT2) are important in the metabolism of aromatic and heterocyclic amine carcinogens that induce prostate tumors in the rat...
  54. ncbi Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population
    Shogo Ozawa
    Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    Int J Cancer 102:418-21. 2002
    ..and O-acetylation by phenol sulfating sulfotransferase, ST1A3 (SULT1A1), and arylamine N-acetyltransferase, NAT2, respectively...
  55. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
    ..glutathione S-transferase (GSTM1, GSTP1 and GSTT1), sulfotransferase (SULT1A1 and SULT1A2), N-acetyl transferase 2 (NAT2), NAD(P)H:quinone oxidoreductase (NQO1), methylenetetrahydrofolate reductase (MTHFR), and microsomal epoxide ..
  56. ncbi Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer
    J H Barrett
    Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, UK
    Carcinogenesis 24:275-82. 2003
    Fast N-acetyltransferase 2 (NAT2) acetylators may be at increased risk of colorectal cancer through the activation of carcinogenic heterocyclic amines (HA), which are produced by meat cooked at high temperatures and are found in cigarette ..
  57. pmc Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, Houston, TX 77030, USA
    Carcinogenesis 27:103-11. 2006
    ..e. cytochrome P450 1A2 (CYP1A2) and N-acetyltransferase 1 and 2 (NAT1 and NAT2), in a hospital-based case-control study of 365 patients with pancreatic adenocarcinoma and 379 frequency-matched ..
  58. ncbi Association of N-acetyl transferase 2 gene polymorphism and slow acetylator phenotype with young onset and late onset Parkinson's disease among Indians
    Shashi Chaudhary
    Department of Genetics, University of Delhi South Campus, New Delhi, India
    Pharmacogenet Genomics 15:731-5. 2005
    ....
  59. ncbi Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:99-107. 2006
    N-Acetyltransferases 1 and 2 (NAT1 and NAT2), both being highly polymorphic, are involved in the metabolism of aromatic and heterocyclic aromatic amines present in cigarette smoke and red meat cooked by high-temperature cooking techniques...
  60. ncbi The influence of various genotypes on the metabolic activity of NAT2 in a Chinese population
    Bing Chen
    Department of Pharmacy, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People s Republic of China
    Eur J Clin Pharmacol 62:355-9. 2006
    To determine the phenotype and genotype of NAT2 in a Chinese population and study the influence of various NAT2 genotypes on the NAT2 activity.
  61. ncbi Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and genetic polymorphisms in breast cancer patients
    Hsien Wen Kuo
    Institute of Environmental Health, China Medical University, No 91, Hsueh Shin Road, Taichung, Taiwan
    Mutat Res 631:62-8. 2007
    ..However, it was found that breast cancer was not significantly influenced by CYP1A1, CYP1M1 or NAT2 polymorphisms...
  62. ncbi NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan
    Chi Chou Huang
    Colorectal Division, Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan, Republic of China
    Dis Colon Rectum 50:981-9. 2007
    ..Heterocyclic amines from dietary cooked meats are metabolically activated by NAT2 (N-acetyltransferase 2), which are associated with colorectal cancer incidence...
  63. pmc Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma
    Suhal S Mahid
    Price Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA
    BMC Med Genet 8:28. 2007
    N-acetyltransferase 1 (NAT1) and 2 (NAT2) are polymorphic isoenzymes responsible for the metabolism of numerous drugs and carcinogens...
  64. ncbi Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis
    Simon Sanderson
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    Am J Epidemiol 166:741-51. 2007
    ..review and evidence synthesis, the authors investigated the joint effects of the N-acetyltransferase genes NAT1 and NAT2 and cigarette smoking on bladder carcinogenesis...
  65. doi Prospective study of NAT1 and NAT2 polymorphisms, tobacco smoking and meat consumption and risk of colorectal cancer
    Mette Sørensen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Cancer Lett 266:186-93. 2008
    Heterocyclic amines in tobacco smoke and fried meat are activated or detoxified by N-acetyltransferases (NAT1 and NAT2). We identified 379 cases with colorectal cancer (CRC) and 769 sub-cohort members among a cohort of 57,000 members...
  66. ncbi Prospective study of the association between NAT2 gene haplotypes and severe adverse events with sulfasalazine therapy in patients with rheumatoid arthritis
    Makoto Soejima
    J Rheumatol 35:724. 2008
  67. doi Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: a hospital-based case-control study in Japan
    Minatsu Kobayashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Scand J Gastroenterol 44:952-9. 2009
    ..A further objective was to investigate the possible effect of genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on colorectal cancer.
  68. doi Sequence analysis of NAT2 gene in Brazilians: identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure
    Raquel L F Teixeira
    Laboratory of Human Genetics, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
    Mutat Res 683:43-9. 2010
    N-Acetyltransferase 2 (NAT2) metabolizes a variety of xenobiotics that includes many drugs, chemicals and carcinogens...
  69. ncbi Phenotyping with sulfasalazine - time dependence and relation to NAT2 pharmacogenetics
    U D Kuhn
    Institute for Pharmacology and Toxicology, Division of Clinical Pharmacology, Medical Faculty Friedrich Schiller University Jena, Dornburger Strasse 159, 07740 Jena, Germany
    Int J Clin Pharmacol Ther 48:1-10. 2010
    N-acetyltransferase 2 (NAT2) genotype-phenotype relation with sulfasalazine as probe drug by means of detailed genotype analysis and kinetic data evaluation.
  70. doi NAT2 polymorphism and lung cancer risk: a meta-analysis
    Dan Cui
    Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 450001 Zhengzhou, China
    Lung Cancer 73:153-7. 2011
    N-acetyltransferase 2 (NAT2) gene encodes a key enzyme involved in the metabolism of xenobiotics and whose polymorphisms have been related to individual susceptibility to several malignancies...
  71. doi NAT2 and CYP2E1 polymorphisms associated with antituberculosis drug-induced hepatotoxicity in Chinese patients
    Hui ru An
    Institute of Tuberculosis Research, 309th Hospital of Chinese People s Liberation Army, Beijing, China
    Clin Exp Pharmacol Physiol 39:535-43. 2012
    ..of two important drug-metabolizing enzymes involved in the metabolism of isoniazid, namely N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1). 2...
  72. pmc Diverse point mutations in the human gene for polymorphic N-acetyltransferase
    K P Vatsis
    Department of Pharmacology, Medical School, University of Michigan, Ann Arbor 48109 0626
    Proc Natl Acad Sci U S A 88:6333-7. 1991
    ..3.1.5), NAT1 and NAT2, presumably code for the genetically invariant and variant NAT proteins, respectively...
  73. pmc Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, blacks, Hispanics, and whites: application to metabolic epidemiology
    H J Lin
    Department of Pediatrics, Harbor UCLA Medical Center, Torrance 90502
    Am J Hum Genet 52:827-34. 1993
    ..determine the population frequencies of the major slow acetylator alleles of the polymorphic N-acetyltransferase (NAT2) gene, whose locus maps to chromosome 8...
  74. ncbi Allelic polymorphism of GSTM1 and NAT2 genes modifies dietary-induced DNA damage in colorectal mucosa
    I Kiss
    Department of Public Health, Medical Faculty, University of Sciences Pécs, Hungary
    Eur J Cancer Prev 9:429-32. 2000
    ..Our study emphasizes the importance of using susceptibility markers in cancer epidemiology, since environmental effects are strongly modified by these genetic factors...
  75. ncbi Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk
    L Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    Cancer Epidemiol Biomarkers Prev 10:1259-66. 2001
    ..increases the risk of colorectal cancer (CRC), especially in individuals with the rapid phenotype for CYP1A2 and NAT2. This association may be particularly strong in smokers because smoking is known to induce CYP1A2...
  76. ncbi N-acetyltransferase 2 polymorphism in sporadic Parkinson's disease in a Polish population
    Monika Bialecka
    Department of Pharmacology, Pomeranian Academy of Medicine, Szczecin, Poland
    Eur J Clin Pharmacol 57:857-62. 2002
    ..This study was carried out to determine the presence of N-acetyltransferase 2 polymorphism in Parkinson's disease patients in a Polish population...
  77. ncbi The role of N-acetyltransferase-2 and glutathione S-transferase on the risk and aggressiveness of bladder cancer
    Xenofon Giannakopoulos
    Department of Urology Laboratory of Molecular Urology, Ioannina University School of Medicine, 451 10 Ioannina, Greece
    Anticancer Res 22:3801-4. 2002
    ..Studies that will simultaneously examine the role of several genetic and environmental factors involved in bladder carcinogenesis are needed to give a global picture for the risk factors of bladder cancer and their potential interaction...
  78. ncbi Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease
    J M van der Walt
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 60:1189-91. 2003
    ..linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single ..
  79. ncbi Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR
    Gail McKeown-Eyssen
    Departments of Public Health Sciences, University of Toronto, ON, Canada
    Int J Epidemiol 33:971-8. 2004
    ..Because genetic variation alters the rate of chemical metabolism, this study was designed to determine if MCS cases differed from controls for genetic polymorphisms in drug-metabolizing enzymes...
  80. ncbi Effects of N-acetyl transferase 1 and 2 polymorphisms on bladder cancer risk in Caucasians
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mutat Res 581:97-104. 2005
    ..Two distinct N-acetyl transferase (NAT) enzymes, NAT1 and NAT2, play important roles in the bio-activation and detoxification of these carcinogens...
  81. pmc Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2
    Yu Zang
    Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Carcinogenesis 28:1665-71. 2007
    Human N-acetyltransferase 2 (NAT2) is polymorphic in humans and may associate with cancer risk by modifying individual susceptibility to cancers from carcinogen exposure...
  82. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions...
  83. ncbi Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver
    S Ohsako
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neurosciences, Japan
    J Biol Chem 265:4630-4. 1990
    ....
  84. ncbi Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression
    M Blum
    Department of Pharmacology, University of Basel, Switzerland
    DNA Cell Biol 9:193-203. 1990
    ..None of the three genomic coding sequences was interrupted by introns. Two genes, designated NAT1 and NAT2, each possessed open reading frames of 870 bp. Both genes have been assigned to human chromosome 8, pter-q11...
  85. pmc Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation
    D M Grant
    Department of Pharmacology, University of Basel, Switzerland
    Nucleic Acids Res 17:3978. 1989
  86. ncbi N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review
    N Brockton
    Department of Medicine and Therapeutics, University of Aberdeen, Scotland, United Kingdom
    Am J Epidemiol 151:846-61. 2000
    The two expressed genes coding for N-acetyltransferase (NAT) activity, NAT1 and NAT2, are located on chromosome 8 at 8p21.3-23.1 and are polymorphic...
  87. ncbi Cytochrome P4501A2 (CYP1A2) activity and lung cancer risk: a preliminary study among Chinese women in Singapore
    A Seow
    Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive, MD3, 117597, Singapore
    Carcinogenesis 22:673-7. 2001
    ..Hepatic CYP1A2 and NAT2 are involved in the metabolism of carcinogenic arylamines, and NAT2 also catalyzes the detoxification pathway for ..
  88. ncbi Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer
    Pervez F Firozi
    Department of Gastrointestinal Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 23:301-6. 2002
    ..breast tissues and polymorphisms of the drug-metabolizing genes cytochrome P4501A1 (CYP1A1), N-acetyltransferase-2 (NAT2), and glutathione S-transferase M1 (GSTM1), in 166 women having breast cancer...
  89. ncbi [Relationship between polymorphism of N-acetyltransferase 2 and genetic susceptibility to laryngeal carcinoma]
    Dapeng Lei
    Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Jinan 250012, China
    Zhonghua Zhong Liu Za Zhi 24:154-6. 2002
    To investigate the relationship between polymorphism of N-acetyltransferase (NAT2) gene and genetic susceptibility to laryngeal carcinoma.
  90. ncbi Differences in N-acetylation genotypes between Caucasians and Black South Africans: implications for cancer prevention
    Alexandre Loktionov
    Dunn Human Nutrition Unit, MRC Wellcome Trust, Cambridge, UK
    Cancer Detect Prev 26:15-22. 2002
    Polymorphic N-acetyltransferase genes (NAT1 and NAT2) determine rapid or slow acetylation phenotypes, which are believed to affect cancer risk related to environmental exposure...
  91. ncbi N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitis
    Elena Ricart
    Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Am J Gastroenterol 97:1763-8. 2002
    ..mucosa by N-acetyltransferase 1 (NAT1), and sulfapyridine is metabolized in the liver by N-acetyltransferase 2 (NAT2). Common genetic polymorphisms in these enzymes result in rapid and slow acetylation...
  92. ncbi Differential effect of NAT2 on the association between active and passive smoke exposure and breast cancer risk
    Jenny Chang-Claude
    Division of Clinical Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 11:698-704. 2002
    Polymorphisms in the N-acetyltransferase 2 (NAT2) gene influence the rate of metabolism of aromatic and heterocyclic amines present in tobacco smoke...
  93. ncbi Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis
    Yi Shin Huang
    Division of Gastroenterology, Department of Medicine, and the Chest Department, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
    Hepatology 37:924-30. 2003
    ..Their CYP2E1 and NAT2 genotypes were determined using a polymerase chain reaction with restriction fragment length polymorphism method...
  94. pmc Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR-1 in the Egyptian population
    Samar I Hamdy
    Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan, and Faculty of Pharmacy, Cairo University, Egypt
    Br J Clin Pharmacol 55:560-9. 2003
    The goal of this study was to determine the frequencies of important allelic variants in the TPMT, NAT2, GST, SULT1A1 and MDR-1 genes in the Egyptian population and compare them with the frequencies in other ethnic populations.
  95. ncbi Polymorphism of the N-acetyltransferase 2 gene, red meat intake, and the susceptibility of hepatocellular carcinoma
    Yi Shin Huang
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan
    Am J Gastroenterol 98:1417-22. 2003
    ..The aim of this study was to evaluate the relationship of NAT2 genetic polymorphisms with hepatocellular carcinoma (HCC), with special reference to the interaction of dietary ..
  96. ncbi N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosus
    Glinda S Cooper
    Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
    J Rheumatol 31:76-80. 2004
    To examine the association between N-acetyl transferase (NAT) genotype (NAT1 and NAT2) and risk of developing systemic lupus erythematosus (SLE).
  97. ncbi Risk of colorectal adenomas in relation to meat consumption, meat preparation, and genetic susceptibility in a Dutch population
    Edine W Tiemersma
    Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, The Netherlands
    Cancer Causes Control 15:225-36. 2004
    ..We studied the association between meat consumption and colorectal adenomas, and potential influence of genetic susceptibility to heterocyclic aromatic amines (HCAs) formed during meat cooking at high temperatures...
  98. pmc NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant
    Nichola Johnson
    University Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    BMC Med Genet 5:6. 2004
    ..The purpose of this study was to determine whether polymorphisms in the human NAT genes influence susceptibility to Alzheimer's disease...
  99. ncbi The influence of human N-acetyltransferase genotype on the early bactericidal activity of isoniazid
    P R Donald
    Department of Paediatrics and Child Health, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
    Clin Infect Dis 39:1425-30. 2004
    The elimination of isoniazid is subject to the influence of the N-acetyltransferase 2 (NAT2) genotype, and individuals may be homozygotic slow, heterozygotic fast, or homozygotic fast acetylators of isoniazid...
  100. ncbi NAT2 slow acetylator genotype as an important modifier of breast cancer risk
    Pia Sillanpää
    Finnish Institute of Occupational Health, Helsinki, Finland
    Int J Cancer 114:579-84. 2005
    N-acetyltransferase 2 (NAT2) is a polymorphic enzyme participating in the metabolism of numerous pharmaceutical drugs and carcinogens found in tobacco smoke and diet...

Research Grants79

  1. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    Michael Fasullo; Fiscal Year: 2007
    ..Heterocyclic aromatic amines (HAs) require additional activation by N,O- acetyltransferase (NAT2)...
  2. Genetic polymorphisms in 5'-UTR of human NAT1 and NAT2
    Anwar Husain; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): This project will characterize the minimal promoter region of human NAT1 and NAT2 and study effects of genetic polymorphisms on expression in human mammary cells...
  3. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2001
    ..EPHX), cytochrome p450 2E1 (CYP2E1), alcohol dehydrogenase type 3 (ADH3), N-acetyltransferase types 1 and 2 (NAT1, NAT2), and NAD(P)H:quinone oxidoreductase (NQ01)...
  4. RACHEL FYNVOLA TYNDALE; Fiscal Year: 2014
    ..The goal of the Pharmacogenetics of Nicotine Addiction Treatment (PNAT) research program is to generate the evidence base to optimize treatment decisions for Individuals who want to quit ..
  5. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
    ..Heterocyclic aromatic amines (HAs) require additional activation by N,O-acetyltransferase (NAT2)...
  6. Gregory P Bisson; Fiscal Year: 2014
    ..aspect of this proposal is that both aims will take into account variability in the N- acetyltransferase 2 (NAT2) allele, which is a major determinant of INH CL...
  7. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..causes bladder ABP-DNA adducts and tumor formation as the consequence of hepatic CYP1A2 and N-acetyltransferase (NAT2) levels, as well as urinary pH...
  8. Pharmacogenetics of sulfamethoxazole in HIV/AIDS patients
    Danxin Wang; Fiscal Year: 2009
    ..Several pathways determine SMX hypersensitivity: Metabolic inactivation by N-acetyltransferases 1 and 2 (NAT1 and NAT2);metabolic oxidation to toxic hydroxylamine derivatives by CYP2C9 and other (extra-) hepatic enzymes;protection ..
  9. GENE-ENVIRONMENT EFFECTS AND COLON ADENOMAS
    Henry Lin; Fiscal Year: 2000
    ..The project will characterize polymorphic genes for NAT1, NAT2, GSTM1, GSTM3, GSTT1, PGHS-1, PGHS-2, and cPLA2 in all subjects...
  10. Molecular Analysis of the Mitochondrial ADP/ATP Carrier Protein Complexes
    Rosemary Stuart; Fiscal Year: 2009
    ..of adPEO is characterized by a loss of COX activity and modeling of the disease in yeast using the hANT1 ortholog, AAC2, has indicated that it is the structural presence of a mutated AAC family member, rather than a compromised ..
  11. RISK FACTORS AND BIOMARKERS FOR IN SITU BREAST CANCER
    Linda Titus Ernstoff; Fiscal Year: 1999
    ..to evaluate the relationship between BCIS (and its subtypes) to p53 mutations, HER-2/neu amplifications, and NAT2 genotype...
  12. Diet, gene-diet interactions and risk of Parkinson's
    Honglei Chen; Fiscal Year: 2004
    ..In the HPFS and NHS cohorts, he will evaluate the associations of PD risk with common polymorphisms of NAT2, CYP1A2, ADH2, ADH3, ADH4, and MTHFR...
  13. IDENTIFYING MODIFYING GENES IN BRCA1 MUTATION CARRIERS
    Katherine Nathanson; Fiscal Year: 2005
    ..is preliminary data from several association studies, looking at HRAS, APC, the androgen receptor, AIB1, hRad51 and NAT2, which demonstrate that certain alleles of these genes modify penetrance in BRCA1 mutation carriers...
  14. PHARMACOGENETIC DETERMINANTS OF FETAL SOMATIC MUTATION
    Marjorie Romkes; Fiscal Year: 2002
    ..in the metabolism of chemicals found in cigarette smoke, specifically CYP1A1, CYP2E1, GSTM1, GSTT1, NAT1*, and NAT2*...
  15. Acetylator-based Individualized Dosing of Amonadife
    John Lister James; Fiscal Year: 2005
    ..In our phase I proposal, we developed a rapid method for NAT2 phenotyping...
  16. Gene-Environment Interactions in RA Autoimmunity and Disease Severity
    Ted Mikuls; Fiscal Year: 2009
    ..to SE, genetic factors to be studied will include DME polymorphisms (in genes encoding N-acetyltransferase [NAT]1, NAT2, microsomal epoxide hydrolase, and glutathione S-transferase), and protein tyrosine phosphatase (PTPN22)...
  17. Population Study of Rectal Cancer in Blacks and Whites
    Robert Sandler; Fiscal Year: 2005
    ..The study will focus on the known alleles of the N-acetyltransferase genes (NAT1 and NAT2) and manganese superoxide dismutase (MnSOD) genes using DNA obtained from blood samples...
  18. Comprehensive Assessment of Bladder Cancer Genetic Susceptibility
    Angeline Andrew; Fiscal Year: 2007
    ..g., NAT2). However, results for a number of polymorphisms are inconsistent...
  19. Microarray-based genotyping for studying susceptibility to mesothelioma
    Stefano Landi; Fiscal Year: 2007
    ..For example, previous studies showed a higher risk for people with GSTM1 null genotype and NAT2 slow acetylators The aim of the present project is to dissect the influence of genes in the etiology of this ..
  20. COHORT STUDY OF GENETIC MARKERS IN COLON CANCER
    David Hunter; Fiscal Year: 2005
    ..They hypothesize that "fast acetylator" NAT2 genotype, a recently described defect in NAT1, homozygous deletions in the GSTM1 gene, and the "extensive ..
  21. Using Tobacco Biomarkers to Improve Smoking Cessation Rates
    Stephen Wilson; Fiscal Year: 2009
    ..differences in DNA adducts, we will explore whether polymorphisms in 4 candidate genes (GSTM1, GSTT1, GSTP1, and NAT2) modify the relationship between African American race and WBC DNA adducts...
  22. Gene-gene interaction in nasopharyngeal carcinoma
    YIN YAO; Fiscal Year: 2005
    ..of 5 CYP genes (CYP1A1, CYP1A2, CYP2D6, CYP2E1, CYP1B1) and a few other polymorphisms (GSTM1, GSTT1, NQO1, NAT1 and NAT2) contribute to the development of NPC and to test for the interaction with high risk genotypes and modifiable risk ..
  23. PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISM
    David Hein; Fiscal Year: 2009
    ..breast cancer in those individuals with rapid and/or slow acetylator N-acetyltransferase- 1 (NAT1) and - 2 (NAT2) acetylator genotypes...
  24. GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTS
    Brian Henderson; Fiscal Year: 2000
    ..Specifically, this proposal will investigate polymorphisms in candidate genes (NAT2, GSTM1, CYP1A1, SRD5A2, AR, EDH17B2, CYP17, and ER), that might alter metabolism of relevant endogenous or ..
  25. Molecular Genetics of NAT1 and NAT2 in Prostate Cancer
    Nicholas Lang; Fiscal Year: 2005
    ..Our preliminary data has shown that elevated NAT2 enzyme activity is strongly associated with increased risk of prostate cancer in both Caucasian and African-..
  26. GENE-ENVIRONMENT INTERACTIONS: THE ODYSSEY COHORT
    Sandra Hoffman; Fiscal Year: 2003
    ..hormones (MTHFR, VDR, CYP17, CYP1B1, COMT, CYP3A4 ); 2) metabolize carcinogens (ADH, GSTM1, GSTT1, GSTP1, NAT1 and NAT2, NOS, CYP1A1, CYP1B1, EH); and 3) control DNA repair processes (XRCC1, XRCC3, XPD)...
  27. Urinary proteomics in aminoglycoside treated newborns
    Mary Kennedy; Fiscal Year: 2008
    ..The results of this research may allow us to identify infants who are at risk for developing significant injury before it occurs. [unreadable] [unreadable] [unreadable]..
  28. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2008
    ..e. CYP1A2, CYP1B1, CYP2E1, NAT1, NAT2, SUL1A1, UGT1A1 and GSTT1, and a DNA repair gene, XRCCI...
  29. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    ..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
  30. ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUT
    RALPH DELFINO; Fiscal Year: 2001
    ..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
  31. Colonoscopic Analysis of Response of Murine Colon Lesions to Drug Intervention
    MARGIE CLAPPER; Fiscal Year: 2008
    ..These results could lead to the establishment of the first accepted therapy for the prevention of colon cancer. [unreadable] [unreadable] [unreadable]..
  32. UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Ethnic/Racial Minorities in the Colon CFR
    Loic Le Marchand; Fiscal Year: 2008
    ..abstract_text> ..
  34. GENETIC LINKAGE IN COLORECTAL CANCER FAMILES
    Ellen Goode; Fiscal Year: 2008
    ..A key future aim is to combine these families with those of other CRC linkage studies in the US and UK to amass an extensive resource with further increased power to understand CRC genetic susceptibility. ..
  35. Conotruncal defects: genetic and nutritional risk
    EDWARD JAMES LAMMER; Fiscal Year: 2010
    ....
  36. Genetic Studies of Clubfoot (ITEV)
    Jacqueline T Hecht; Fiscal Year: 2010
    ..Identification of high-risk genotypes can lead to the development of prevention programs in selected populations and may suggest gene-based prevention strategies. ..
  37. Dietary Factors in the Etiology of Colorectal Cancer
    Jian Min Yuan; Fiscal Year: 2008
    ..Several enzymes that are encoded by cytochrome P4501A2 (CYP1A2), N-acetyltransferase 2 (NAT2) and possibly NAT1 are involved in this HAA activating pathway...
  38. Lung cancer molecular markers by sex: intergroup study
    Christine Ambrosone; Fiscal Year: 2008
    ..Results from this study, the largest to date to evaluate biomarkers of susceptibility and effect, will likely elucidate reasons for the rise in lung cancer, particularly adenocarcinomas, in smoking and non-smoking women. ..
  39. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  40. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2010
    ..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
  41. Novel approach to measure DNA adducts in humans
    ROBERT TURESKY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  42. Human Gut Microflora Profiling for Population Studies
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  43. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  44. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  45. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  46. P-glycoprotein and Steroid-Resistant Nephrotic Syndrome
    LYNDA WELAGE; Fiscal Year: 2005
    ..abstract_text> ..
  47. HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCE
    Johanna Lampe; Fiscal Year: 2002
    ..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
  48. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  49. Modification of tamoxifen effectiveness by gene polymorphisms and other drugs
    Timothy Lash; Fiscal Year: 2009
    ..Understanding the modification of tamoxifen effectiveness by genetic polymorphisms or drug interactions will help patients and physicians to make fully informed decisions about hormone therapy. ..
  50. Hawaii Colorectal Cancer Family Registry
    Loic Le Marchand; Fiscal Year: 2008
    ..We will also propose a CFR pilot study exploring the feasibility of assessing assorted mating as evidence for population stratification. ..
  51. Pharmacogenetics: Breast Cancer Treatment and Prognosis
    Christine Ambrosone; Fiscal Year: 2005
    ..Individualized dosing according to genotype could contribute to increased efficacy and decreased toxicity among patients being treated for cancer. ..
  52. Antioxidant supplements, genetics, and chemotherapy outcomes
    Christine Ambrosone; Fiscal Year: 2009
    ....
  53. Metabolism and Pharmacogenetics in MDMA-Induced Toxicity
    Rafael de la Torre; Fiscal Year: 2009
    ..A study will compare MDMA toxicity when co-adminsitered with the MRP1 inhibitor probenecid. ..
  54. COMMUNITY BASED STUDY ON OCCUPATIONAL ASTHMA, ECRHS-OA
    Manolis Kogevinas; Fiscal Year: 2001
    ..abstract_text> ..
  55. Cancer Incidence among Transplant Recipients:1990-2001
    LESLEY BUTLER; Fiscal Year: 2004
    ..abstract_text> ..
  56. DNA Damage: Fruit & Vegetable Effects in a Feeding Trial
    Johanna Lampe; Fiscal Year: 2005
    ..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
  57. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
  58. GENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERS
    Loic Le Marchand; Fiscal Year: 2004
    ..The elucidation of the main enzymes responsible for carcinogen activation and of the impact of dietary factors on these enzymes would have important implications for cancer prevention. ..
  59. THE SINGAPORE COHORT STUDY OF DIET AND CANCER
    Jian Min Yuan; Fiscal Year: 2009
    ....
  60. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2010
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  61. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2003
    ..Our ultimate goal is to provide information to identify women at high risk of breast cancer, and to aid in the formulation of prevention strategies for these women. ..
  62. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  63. Disruption of Glutathione S-Transferase M1 in Mice
    MARGIE CLAPPER; Fiscal Year: 2006
    ..abstract_text> ..
  64. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2007
    ..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
  65. Diet, Genetic Susceptibility and Colorectal Neoplasia
    Loic Le Marchand; Fiscal Year: 2006
    ..Genotyping for random markers will permit to exclude residual confounding by ethnicity. ..
  66. DIETARY FACTORS IN THE ETIOLOGY OF CANCER IN SHANGHAI
    Jian Min Yuan; Fiscal Year: 2006
    ..In all instances of diet-cancer investigations, relevant genes with potential modifying effects on the respective diet-cancer associations will be included in the investigations. ..
  67. Breast and Bone Density: Impact of Colonic Environment
    Johanna Lampe; Fiscal Year: 2006
    ..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
  68. Aspirin, UGT1A6 Genotype, and Colon Gene Expression
    Johanna Lampe; Fiscal Year: 2006
    ..By targeting relevant pathways, side effects caused by the use of NSAIDs or specific Cox-2 inhibitors may be avoided. ..
  69. Case-Control Study of Adenoma in Sao Paulo Japanese
    Loic Le Marchand; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  70. Crystallographic Analysis of GHMP kinases
    Hong Zhang; Fiscal Year: 2005
    ....
  71. Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  72. Synergism of Gene and Environment in Cancer Studies: A New Bayesian Approach
    Bhramar Mukherjee; Fiscal Year: 2008
    ..The methods developed may be routinely applied to various epidemiological studies of gene-environment interaction. [unreadable] [unreadable] [unreadable] [unreadable]..
  73. RA Comorbidity Bone Health in Men and African Americans
    Ted Mikuls; Fiscal Year: 2008
    ..Mikuls' continued development as an independent clinical investigator. ..
  74. The TGFbeta Pathway, Gene Variants and Colorectal Neopl*
    Loic Le Marchand; Fiscal Year: 2005
    ..abstract_text> ..
  75. Seattle Colorectal Cancer Family Registry (CFR)
    Polly Newcomb; Fiscal Year: 2007
    ..The CCFR - S provides an important\par population-based perspective within our consortium studies of colorectal cancer.\fs20\par \par } ..
  76. Risk Factors for Molecularly Defined Subgroups of Lymphoma: A Pooled Analysis
    Brian Chiu; Fiscal Year: 2008
    ..This project directly responds to the NCI strategic plan for cancer preemption because it can elucidate the etiology of NHL. [unreadable] [unreadable] [unreadable]..
  77. Race & Risk Factors for Early/Aggressive Breast Cancer
    Christine Ambrosone; Fiscal Year: 2008
    ..Results from this study will provide much-needed answers as to why African-American women are more likely than Caucasians to be diagnosed with more aggressive disease at an earlier age. ..