NFKBIL1

Summary

Gene Symbol: NFKBIL1
Description: NFKB inhibitor like 1
Alias: IKBL, LST1, NFKBIL, NF-kappa-B inhibitor-like protein 1, I-kappa-B-like protein, ikappaBL, inhibitor of kappa B-like protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Species: human
Products:     NFKBIL1

Top Publications

  1. de la Concha E, Fernandez Arquero M, Lopez Nava G, Martin E, Allcock R, Conejero L, et al. Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL. Gastroenterology. 2000;119:1491-5 pubmed
    b>IKBL gene lies telomeric of the tumor necrosis factor cluster in the central major histocompatibility complex and carries a structural polymorphism at position +738...
  2. Shichi D, Kikkawa E, Ota M, Katsuyama Y, Kimura A, Matsumori A, et al. The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy. Tissue Antigens. 2005;66:200-8 pubmed
    ..We mapped HCV-DCM susceptibility to a non-HLA gene locus spanning from NFKBIL1 to MICA gene loci within the MHC class III-class I boundary region...
  3. Owecki M, Kowal P, Kaczmarek Ryśs M, Hoppe Gołebiewska J, Nikisch E, Tokarz Kupczyk E, et al. [Association study between exon 4 NFKBIL1 polymorphism and multiple sclerosis]. Pol Merkur Lekarski. 2010;28:366-70 pubmed
    ..3). NFKBIL1 gene (locus 6p21.31) is one of candidate genes...
  4. Albertella M, Campbell R. Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins. Hum Mol Genet. 1994;3:793-9 pubmed
    ..It contains one partial and two full ANK repeats, which bear a marked similarity to those in the I kappa B family of proteins, suggesting that the protein encoded by the novel gene could represent a divergent member of this family. ..
  5. Allcock R, Christiansen F, Price P. The central MHC gene IKBL carries a structural polymorphism that is associated with HLA-A3,B7,DR15. Immunogenetics. 1999;49:660-5 pubmed
    ..Here we address the IKBL gene, which lies near the TNF cluster at the telomeric end of the central MHC...
  6. Lin C, Cho C, Tsai W, Ou T, Wu C, Yen J, et al. Inhibitors of kB-like gene polymorphisms in rheumatoid arthritis. Immunol Lett. 2006;105:193-7 pubmed
    To investigate the role of inhibitor of kB-like (IkBL) gene polymorphisms in the pathogenesis of rheumatoid arthritis (RA) in Taiwan. One hundred and twenty-nine patients with RA and 110 healthy controls were enrolled in this study...
  7. Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, et al. Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis. Am J Hum Genet. 2003;72:303-12 pubmed
    ..Therefore, the MHC may harbor RA genetic determinants affecting the innate and adaptive arms of the immune system. ..
  8. Shibata H, Yasunami M, Obuchi N, Takahashi M, Kobayashi Y, Numano F, et al. Direct determination of single nucleotide polymorphism haplotype of NFKBIL1 promoter polymorphism by DNA conformation analysis and its application to association study of chronic inflammatory diseases. Hum Immunol. 2006;67:363-73 pubmed
    ..susceptibility genes for Takayasu's arteritis (TA) was mapped between TNFA and MICB loci and that -63T allele of NFKBIL1, which is between TNFA and MICB loci, was associated with rheumatoid arthritis (RA) in the Japanese population...
  9. Iris F, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, et al. Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. Nat Genet. 1993;3:137-45 pubmed
    ..The most telomeric 3.8 kb contains three potential exons, one of which bears strong homology to the ankyrin domain of the DNA binding factors NF kappa B and I kappa B. ..
  10. Glas J, Török H, Tonenchi L, Muller Myhsok B, Mussack T, Wetzke M, et al. Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes. Inflamm Bowel Dis. 2006;12:606-11 pubmed
    ..Furthermore, potential interactions of the -94ins/delATTG polymorphism with the IKBL and the IL-1RN genes should be determined...

Detail Information

Publications43

  1. de la Concha E, Fernandez Arquero M, Lopez Nava G, Martin E, Allcock R, Conejero L, et al. Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL. Gastroenterology. 2000;119:1491-5 pubmed
    b>IKBL gene lies telomeric of the tumor necrosis factor cluster in the central major histocompatibility complex and carries a structural polymorphism at position +738...
  2. Shichi D, Kikkawa E, Ota M, Katsuyama Y, Kimura A, Matsumori A, et al. The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy. Tissue Antigens. 2005;66:200-8 pubmed
    ..We mapped HCV-DCM susceptibility to a non-HLA gene locus spanning from NFKBIL1 to MICA gene loci within the MHC class III-class I boundary region...
  3. Owecki M, Kowal P, Kaczmarek Ryśs M, Hoppe Gołebiewska J, Nikisch E, Tokarz Kupczyk E, et al. [Association study between exon 4 NFKBIL1 polymorphism and multiple sclerosis]. Pol Merkur Lekarski. 2010;28:366-70 pubmed
    ..3). NFKBIL1 gene (locus 6p21.31) is one of candidate genes...
  4. Albertella M, Campbell R. Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins. Hum Mol Genet. 1994;3:793-9 pubmed
    ..It contains one partial and two full ANK repeats, which bear a marked similarity to those in the I kappa B family of proteins, suggesting that the protein encoded by the novel gene could represent a divergent member of this family. ..
  5. Allcock R, Christiansen F, Price P. The central MHC gene IKBL carries a structural polymorphism that is associated with HLA-A3,B7,DR15. Immunogenetics. 1999;49:660-5 pubmed
    ..Here we address the IKBL gene, which lies near the TNF cluster at the telomeric end of the central MHC...
  6. Lin C, Cho C, Tsai W, Ou T, Wu C, Yen J, et al. Inhibitors of kB-like gene polymorphisms in rheumatoid arthritis. Immunol Lett. 2006;105:193-7 pubmed
    To investigate the role of inhibitor of kB-like (IkBL) gene polymorphisms in the pathogenesis of rheumatoid arthritis (RA) in Taiwan. One hundred and twenty-nine patients with RA and 110 healthy controls were enrolled in this study...
  7. Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, et al. Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis. Am J Hum Genet. 2003;72:303-12 pubmed
    ..Therefore, the MHC may harbor RA genetic determinants affecting the innate and adaptive arms of the immune system. ..
  8. Shibata H, Yasunami M, Obuchi N, Takahashi M, Kobayashi Y, Numano F, et al. Direct determination of single nucleotide polymorphism haplotype of NFKBIL1 promoter polymorphism by DNA conformation analysis and its application to association study of chronic inflammatory diseases. Hum Immunol. 2006;67:363-73 pubmed
    ..susceptibility genes for Takayasu's arteritis (TA) was mapped between TNFA and MICB loci and that -63T allele of NFKBIL1, which is between TNFA and MICB loci, was associated with rheumatoid arthritis (RA) in the Japanese population...
  9. Iris F, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, et al. Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. Nat Genet. 1993;3:137-45 pubmed
    ..The most telomeric 3.8 kb contains three potential exons, one of which bears strong homology to the ankyrin domain of the DNA binding factors NF kappa B and I kappa B. ..
  10. Glas J, Török H, Tonenchi L, Muller Myhsok B, Mussack T, Wetzke M, et al. Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes. Inflamm Bowel Dis. 2006;12:606-11 pubmed
    ..Furthermore, potential interactions of the -94ins/delATTG polymorphism with the IKBL and the IL-1RN genes should be determined...
  11. Greetham D, Ellis C, Mewar D, Fearon U, an Ultaigh S, Veale D, et al. Functional characterization of NF-kappaB inhibitor-like protein 1 (NFkappaBIL1), a candidate susceptibility gene for rheumatoid arthritis. Hum Mol Genet. 2007;16:3027-36 pubmed
    Several studies have implicated the NF-kappaB inhibitor-like protein 1 (NFkBIL1) gene located in the class III region of the major histocompatibility complex (MHC) as a possible susceptibility locus for rheumatoid arthritis (RA)...
  12. Koch W, Hoppmann P, Michou E, Jung V, Pfeufer A, Müller J, et al. TaqMan assays for genotyping of single nucleotide polymorphisms present at a disease susceptibility locus on chromosome 6. Clin Chem Lab Med. 2005;43:167-72 pubmed
    Multiple single-nucleotide polymorphisms in the BAT1-NFKBIL1-LTA region on the short arm of chromosome 6 have been found to be associated with susceptibility to myocardial infarction in a recent case-control study including individuals ..
  13. Tan J, Price P, Gut I, Stacey M, Warrington N, Wallace H. Characterization of tumor necrosis factor-α block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients. Hum Immunol. 2010;71:1214-9 pubmed publisher
    ..FV16 appears to be the best MHC and TNF block marker of susceptibility. After disease onset, an individual's TNF block haplotype does not modulate CVLU severity. ..
  14. Oliveira L, Porta G, Marin M, Bittencourt P, Kalil J, Goldberg A. Autoimmune hepatitis, HLA and extended haplotypes. Autoimmun Rev. 2011;10:189-93 pubmed publisher
    ..genotyped 107 AIH-1 children and up to 326 healthy subjects for TNFA G-308A, TNFA G-238A, LTA A+252G, LTA A+80C, NFKBIL1 T-63A, BAT1 C-348T, BAT1 G-22C, MICA, and HLA-B polymorphisms...
  15. An J, Nakajima T, Shibata H, Arimura T, Yasunami M, Kimura A. A novel link of HLA locus to the regulation of immunity and infection: NFKBIL1 regulates alternative splicing of human immune-related genes and influenza virus M gene. J Autoimmun. 2013;47:25-33 pubmed publisher
    ..Inhibitor of κB-like protein (IκBL), encoded by HLA-linked NFKBIL1, is a protein of unknown function, while genetic variations in NFKBIL1 are known to associate with the ..
  16. Cordeiro Q, Cappi C, Sampaio A, Palácios S, Pereira C, Shavitt R, et al. Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder. Rev Bras Psiquiatr. 2009;31:131-5 pubmed
    ..The nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1) has been suggested as a modulator of the immunological system...
  17. Valdes A, Thomson G. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Diabetes Obes Metab. 2009;11 Suppl 1:46-52 pubmed publisher
    ..Our data confirm that the class III region is involved in T1D susceptibility and suggest that more than one gene in the region is involved. ..
  18. Eike M, Olsson M, Undlien D, Dahl Jørgensen K, Joner G, Rønningen K, et al. Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families. Genes Immun. 2009;10:141-50 pubmed publisher
    ..Our results illustrate the importance of a comprehensive adjustment for LD effects when performing association studies in this complex. ..
  19. Chinoy H, Li C, Platt H, Fertig N, Varsani H, Gunawardena H, et al. Genetic association study of NF-κB genes in UK Caucasian adult and juvenile onset idiopathic inflammatory myopathy. Rheumatology (Oxford). 2012;51:794-9 pubmed publisher
    ..Several genes share homology with the NF-κB family of proteins. This study investigated the role of NF-κB-related genes in disease susceptibility in UK Caucasian IIM...
  20. Gichohi Wainaina W, Melse Boonstra A, Swinkels D, Zimmermann M, Feskens E, Towers G. Common Variants and Haplotypes in the TF, TNF-α, and TMPRSS6 Genes Are Associated with Iron Status in a Female Black South African Population. J Nutr. 2015;145:945-53 pubmed publisher
    ..rs1800629 both in tumor necrosis factor-α (TNF-α) and rs2071592 in nuclear factor κB inhibitor-like protein 1 (NFKBIL1) was associated with higher odds for low SF concentrations (SF < 15 μg/L; OR: 1.86; 95% CI: 1.23, 2...
  21. D Aloia A, Berruti G, Costa B, Schiller C, Ambrosini R, Pastori V, et al. RalGPS2 is involved in tunneling nanotubes formation in 5637 bladder cancer cells. Exp Cell Res. 2018;362:349-361 pubmed publisher
    ..we found that RalGPS2 interacts with the transmembrane MHC class III protein leukocyte specific transcript 1 (LST1) and RalA, leading to the formation of a complex which promotes TNTs generation...
  22. Koch W, Hoppmann P, Michou E, Jung V, Pfeufer A, Mueller J, et al. Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans. Hum Mol Genet. 2007;16:1821-7 pubmed
    Single-nucleotide polymorphisms within the BAT1-NFKBIL1-LTA genomic region (6p21.3) and the LGALS2 gene (22q13...
  23. Ota M, Katsuyama Y, Hamano H, Umemura T, Kimura A, Yoshizawa K, et al. Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis. Immunogenetics. 2007;59:45-52 pubmed
    ..that of single nucleotide polymorphism within the 5'-flanking regions of the TNFA and IkBLI (also known as NFKBIL1) as well as HLA class I and II genes...
  24. Shiina T, Tamiya G, Oka A, Yamagata T, Yamagata N, Kikkawa E, et al. Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region. Genomics. 1998;47:372-82 pubmed
    ..human major histocompatibility complex on chromosome 6, a YAC clone (745D12) covering the 146-kb segment around the IkBL and MICA loci was isolated from a YAC library constructed from the B-cell line, BOLETH...
  25. Neville M, Campbell R. A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. J Immunol. 1999;162:4745-54 pubmed
    ..inflammatory factor 1, G1, 1C7, leukocyte-specific transcript 1 (B144), lymphotoxin B, TNF, lymphotoxin A, NB6, IKBL, BAT1 (centromere to telomere), and their genomic structures have been defined...
  26. Yamashita T, Hamaguchi K, Kusuda Y, Kimura A, Sakata T, Yoshimatsu H. IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese. Tissue Antigens. 2004;63:223-30 pubmed
    ..We investigated the possibility of the inhibitor of kappaB-like (IKBL, also known as 'NFKBIL1') gene as one of these candidates...
  27. Ryan A, O Brien E, Shields D, McManus R. Lack of association between NFKBIL1/LTA polymorphisms and hypertension, myocardial infarct, unstable angina and stable angina in a large Irish population sample. Atherosclerosis. 2008;197:465-6 pubmed
  28. Gomez L, Camargo J, Castiblanco J, Ruiz Narvaez E, Cadena J, Anaya J. Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis. Tissue Antigens. 2006;67:290-6 pubmed
    ..Interleukin-1 beta (IL-1beta) and the inhibitor of kB-like (IkBL) are important molecules that participate in the inflammatory response required for the immunological control of a ..
  29. Clancy R, Marion M, Kaufman K, Ramos P, Adler A, Harley J, et al. Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus. Arthritis Rheum. 2010;62:3415-24 pubmed publisher
    ..These results suggest that variation near genes related to inflammatory and apoptotic responses may promote cardiac injury initiated by passively acquired autoantibodies. ..
  30. Prasad S, Bhatia T, Kukshal P, Nimgaonkar V, Deshpande S, Thelma B. Attempts to replicate genetic associations with schizophrenia in a cohort from north India. NPJ Schizophr. 2017;3:28 pubmed publisher
    ..07); rs3130615, MICB (p = 0.08); rs6916921, NFKBIL1 (p = 0.08) and rs9273012, HLA-DQA1 (p = 0.06) and haplotypic associations (p = 0.01-0...
  31. Ramasawmy R, Fae K, Cunha Neto E, Borba S, Ianni B, Mady C, et al. Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals. Mol Immunol. 2008;45:283-8 pubmed
    ..The human inhibitory kappaB-like gene (IKBL/NFKBIL1), homologous to the IkappaB family of proteins that regulate the NFkappaB family of transcription factors, is ..
  32. Kariz S, Milutinovic A, Bregar D, Terzic I, Terzić R, Lovrecic L, et al. The interleukin-1 receptor antagonist gene and the inhibitor of kappa B-like protein gene polymorphisms are not associated with myocardial infarction in Slovene population with type 2 diabetes. Coll Antropol. 2007;31:503-7 pubmed
    ..gene variable number tandem repeat (IL1RN VNTR) polymorphism and of the inhibitor of kappa B-like protein (IKBL) gene polymorphism with myocardial infarction (MI) in a group of patients with type 2 diabetes...
  33. Sato H, Grutters J, Pantelidis P, Mizzon A, Ahmad T, van Houte A, et al. HLA-DQB1*0201: a marker for good prognosis in British and Dutch patients with sarcoidosis. Am J Respir Cell Mol Biol. 2002;27:406-12 pubmed
    ....
  34. Martinez A, Pascual M, Pascual Salcedo D, Balsa A, Martin J, de la Concha E. Genetic polymorphisms in Spanish rheumatoid arthritis patients: an association and linkage study. Genes Immun. 2003;4:117-21 pubmed
    ..IL-6 -622 promoter SNP, FcgammaRIIIA Val/Phe-158 polymorphism, IL-1 receptor antagonist VNTR, and the IKBL+738 T/C mutation. The analysis has been performed on a case-control study and also on RA trios...
  35. Atzei P, Gargan S, Curran N, Moynagh P. Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways. J Biol Chem. 2010;285:36804-17 pubmed publisher
    ..This study thus defines hCactin as a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. ..
  36. Castiblanco J, Anaya J. The IkappaBL gene polymorphism influences risk of acquiring systemic lupus erythematosus and Sjögren's syndrome. Hum Immunol. 2008;69:45-51 pubmed publisher
    The human inhibitory kappaB-like gene (IkappaBL) maps to a chromosomal region approximately 25 kb telomeric of the TNF gene at 6p21.3...
  37. Kurylowicz A, Miskiewicz P, Bar Andziak E, Nauman J, Bednarczuk T. Association of polymorphism in genes encoding kappaB inhibitors (IkappaB) with susceptibility to and phenotype of Graves' disease: a case-control study. Thyroid Res. 2009;2:10 pubmed publisher
    ..aim of this study was to investigate an association of polymorphisms in two genes encoding NF-kappaB inhibitors: IKBL (encoding inhibitor of kappaB-like) and NFKBIA (encoding kappaB inhibitor alpha), withsusceptibility to and ..
  38. Miterski B, Drynda S, Böschow G, Klein W, Oppermann J, Kekow J, et al. Complex genetic predisposition in adult and juvenile rheumatoid arthritis. BMC Genet. 2004;5:2 pubmed
    ..genotyped for HLA-DRB1, TNFa, TNFA -238a/g, TNFA -308a/g, TNFA -857c/t, TNFR1 -609g/t, TNFR1 P12P, TNFR2 del 15bp, IKBL -332a/g, IKBL -132t/a, IKBL C224R, CTLA4 -318c/t, CTLA4 T17A, PTPRC P57P, MIF -173g/c, the MIF and IFNG ..
  39. Read R, Teare D, Pridmore A, Naylor S, Timms J, Kaczmarski E, et al. The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality. Crit Care Med. 2009;37:1237-43 pubmed publisher
    ..genotyped at eight other markers in strong linkage disequilibrium with TNF (-308); these markers were IkappaBL (-62), BAT3, LST1, NOTCH4 (+1297), NOTCH4 (+3061), CCHCR1 (+436), CCHCR1 (+2271), and LTalpha...
  40. Kominami S, Tanabe N, Ota M, Naruse T, Katsuyama Y, Nakanishi N, et al. HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. J Hum Genet. 2009;54:108-14 pubmed publisher
    ..characteristics of patients stratified by the presence of susceptibility genes implied that the DPB1 gene controlled the severity of the vascular lesion, whereas the IKBL gene (NFKBIL1) was associated with a relatively mild phenotype.
  41. Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Arinami T, Ujike H, et al. Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia. J Hum Genet. 2009;54:62-5 pubmed publisher
    ..Recently, extensive studies have identified some RA susceptibility genes, including NFKBIL1, SLC22A4, RUNX1, FCRL3 and PADI4, in the Japanese population...
  42. Migita O, Noguchi E, Koga M, Jian Z, Shibasaki M, Migita T, et al. Haplotype analysis of a 100 kb region spanning TNF-LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan. Clin Exp Allergy. 2005;35:790-6 pubmed
    ..We screened for mutations in the coding and promoter regions of genes in the TNF-LTA region, including BAT1, NFKBIL1, LTA, TNF, LTB, AIF, and BAT2, and conducted a transmission disequilibrium test of 41 polymorphisms in 137 ..
  43. Yau A, Tuncel J, Haag S, Norin U, Houtman M, Padyukov L, et al. Conserved 33-kb haplotype in the MHC class III region regulates chronic arthritis. Proc Natl Acad Sci U S A. 2016;113:E3716-24 pubmed publisher
    ..haplotype consists of five polymorphic immunoregulatory genes: Lta (lymphotoxin-α), Tnf, Ltb (lymphotoxin-β), Lst1 (leukocyte-specific transcript 1), and Ncr3 (natural cytotoxicity-triggering receptor 3)...