PDK1

Summary

Gene Symbol: PDK1
Description: pyruvate dehydrogenase kinase 1
Alias: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial, pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial, PDH kinase 1, mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1, pyruvate dehydrogenase kinase, isoenzyme 1
Species: human
Products:     PDK1

Top Publications

  1. Gagliardi P, di Blasio L, Orso F, Seano G, Sessa R, Taverna D, et al. 3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner. Neoplasia. 2012;14:719-31 pubmed
    3-phosphoinositide-dependent protein kinase 1 (PDK1) is the pivotal element of the phosphatidylinositol 3 kinase (PI3K) signaling pathway because it phosphorylates Akt/PKB through interactions with phosphatidylinositol 3,4,5 phosphate...
  2. Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, et al. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. PLoS ONE. 2010;5:e9910 pubmed publisher
    ..phosphate-mediated recruitment of AKT and its upstream kinases, including 3-Phosphoinositide-dependent kinase 1 (PDK1), to the inner surface of the cell membrane...
  3. Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002;110:177-89 pubmed
    ..elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo. ..
  4. Sugden M, Holness M. Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. Am J Physiol Endocrinol Metab. 2003;284:E855-62 pubmed
    ....
  5. Lu Z, Cox Hipkin M, Windsor W, Boyapati A. 3-phosphoinositide-dependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway. Mol Cancer Res. 2010;8:421-32 pubmed publisher
    ..This second messenger leads to the recruitment of 3-phosphoinositide-dependent protein kinase-1 (PDK1) to the proximal side of the plasma membrane, which results in the activation of AKT kinase...
  6. Kim J, Tchernyshyov I, Semenza G, Dang C. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006;3:177-85 pubmed
    ..the tricarboxylic acid cycle (TCA) by directly trans-activating the gene encoding pyruvate dehydrogenase kinase 1 (PDK1). PDK1 inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA...
  7. Shen X, Xi G, Radhakrishnan Y, Clemmons D. PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival. J Biol Chem. 2010;285:29416-24 pubmed publisher
    ..Therefore, we investigated the mechanism of PDK1 recruitment to the SHPS-1 signaling complex and the consequences of disrupting PDK1 recruitment for downstream ..
  8. Tian X, Rusanescu G, Hou W, Schaffhausen B, Feig L. PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism. EMBO J. 2002;21:1327-38 pubmed
    ..Here we show that Ral-GEF stimulation by EGF involves an additional mechanism, PI3-K-dependent kinase 1 (PDK1)-induced enhancement of Ral-GEF catalytic activity...
  9. Pinner S, Sahai E. PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nat Cell Biol. 2008;10:127-37 pubmed publisher
    ..In this study, we show that PDK1 is required for phosphorylation of myosin light chain and cell motility, both on deformable gels and in vivo...
  10. Le Good J, Ziegler W, Parekh D, Alessi D, Cohen P, Parker P. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science. 1998;281:2042-5 pubmed
    ..Thus, the PKB kinase PDK1 may be responsible for the phosphorylation of PKC isotypes...

Detail Information

Publications62

  1. Gagliardi P, di Blasio L, Orso F, Seano G, Sessa R, Taverna D, et al. 3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner. Neoplasia. 2012;14:719-31 pubmed
    3-phosphoinositide-dependent protein kinase 1 (PDK1) is the pivotal element of the phosphatidylinositol 3 kinase (PI3K) signaling pathway because it phosphorylates Akt/PKB through interactions with phosphatidylinositol 3,4,5 phosphate...
  2. Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, et al. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. PLoS ONE. 2010;5:e9910 pubmed publisher
    ..phosphate-mediated recruitment of AKT and its upstream kinases, including 3-Phosphoinositide-dependent kinase 1 (PDK1), to the inner surface of the cell membrane...
  3. Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002;110:177-89 pubmed
    ..elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo. ..
  4. Sugden M, Holness M. Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. Am J Physiol Endocrinol Metab. 2003;284:E855-62 pubmed
    ....
  5. Lu Z, Cox Hipkin M, Windsor W, Boyapati A. 3-phosphoinositide-dependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway. Mol Cancer Res. 2010;8:421-32 pubmed publisher
    ..This second messenger leads to the recruitment of 3-phosphoinositide-dependent protein kinase-1 (PDK1) to the proximal side of the plasma membrane, which results in the activation of AKT kinase...
  6. Kim J, Tchernyshyov I, Semenza G, Dang C. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006;3:177-85 pubmed
    ..the tricarboxylic acid cycle (TCA) by directly trans-activating the gene encoding pyruvate dehydrogenase kinase 1 (PDK1). PDK1 inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA...
  7. Shen X, Xi G, Radhakrishnan Y, Clemmons D. PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival. J Biol Chem. 2010;285:29416-24 pubmed publisher
    ..Therefore, we investigated the mechanism of PDK1 recruitment to the SHPS-1 signaling complex and the consequences of disrupting PDK1 recruitment for downstream ..
  8. Tian X, Rusanescu G, Hou W, Schaffhausen B, Feig L. PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism. EMBO J. 2002;21:1327-38 pubmed
    ..Here we show that Ral-GEF stimulation by EGF involves an additional mechanism, PI3-K-dependent kinase 1 (PDK1)-induced enhancement of Ral-GEF catalytic activity...
  9. Pinner S, Sahai E. PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nat Cell Biol. 2008;10:127-37 pubmed publisher
    ..In this study, we show that PDK1 is required for phosphorylation of myosin light chain and cell motility, both on deformable gels and in vivo...
  10. Le Good J, Ziegler W, Parekh D, Alessi D, Cohen P, Parker P. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science. 1998;281:2042-5 pubmed
    ..Thus, the PKB kinase PDK1 may be responsible for the phosphorylation of PKC isotypes...
  11. Peng F, Wang J, Fan W, Meng Y, Li M, Li T, et al. Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia. Oncogene. 2017;: pubmed publisher
    ..Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH+ ..
  12. Lee M, Chen G, Puttock E, Wang K, Edwards R, Waterman M, et al. Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. Mol Syst Biol. 2017;13:912 pubmed publisher
    ..a self-organizing spatial pattern of glycolysis in xenograft colon tumors where pyruvate dehydrogenase kinase (PDK1), a negative regulator of oxidative phosphorylation, is highly active in clusters of cells arranged in a spotted ..
  13. Pópulo H, Caldas R, Lopes J, Pardal J, Máximo V, Soares P. Overexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy. Expert Opin Ther Targets. 2015;19:733-45 pubmed publisher
    ..Our results suggest that PDK expression may play a role in melanoma development and that DCA can be useful for CM therapy, alone or in combination with mTOR inhibitors. ..
  14. Karam M, Legay C, Auclair C, Ricort J. Protein kinase D1 stimulates proliferation and enhances tumorigenesis of MCF-7 human breast cancer cells through a MEK/ERK-dependent signaling pathway. Exp Cell Res. 2012;318:558-69 pubmed publisher
    ....
  15. Wigfield S, Winter S, Giatromanolaki A, Taylor J, Koukourakis M, Harris A. PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer. Br J Cancer. 2008;98:1975-84 pubmed publisher
    ..005 split by median). These results indicate that HIF regulation of PDK-1 has a key role in maintaining lactate production in human cancer and that the investigation of PDK-1 inhibitors should be investigated for antitumour effects. ..
  16. Ohba T, Watanabe H, Murakami M, Radovanovic M, Iino K, Ishida M, et al. Amlodipine inhibits cell proliferation via PKD1-related pathway. Biochem Biophys Res Commun. 2008;369:376-81 pubmed publisher
    ..These data suggest that PKD1 contributes to the antiproliferative effect of amlodipine on hCASMCs via JAK/STAT signaling and p21((Waf1/Cip1)) up-regulation. ..
  17. Gagliardi P, di Blasio L, Primo L. PDK1: A signaling hub for cell migration and tumor invasion. Biochim Biophys Acta. 2015;1856:178-88 pubmed publisher
    ..3-Phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1) is an ancient serine-threonine kinase belonging to AGC kinase family...
  18. Fernandez Monreal M, Sánchez Castillo C, Esteban J. APPL1 gates long-term potentiation through its plekstrin homology domain. J Cell Sci. 2016;129:2793-803 pubmed publisher
    ..Interestingly, inhibitors of PDK1 (also known as PDPK1) and Akt have no effect on LTP expression...
  19. Orlacchio A, Ranieri M, Brave M, Arciuch V, Forde T, De Martino D, et al. SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance. Cancer Res. 2017;77:6914-6926 pubmed publisher
    ..Instead, transformation requires the activity of the PDK1-regulated AGC family of protein kinases...
  20. Rubio M, Avitabile D, Fischer K, Emmanuel G, Gude N, Miyamoto S, et al. Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes. J Mol Cell Cardiol. 2009;47:96-103 pubmed publisher
    The phosphoinositide 3-kinase (PI3K)/phosphoinositide dependent kinase 1 (PDK1) signaling pathway exerts cardioprotective effects in the myocardium through activation of key proteins including Akt...
  21. Zhang Y, Nomura M, Zhong S, Chen N, Bode A, Dong Z. Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. J Biol Chem. 2001;276:20913-23 pubmed
    ..Moreover, p70(S6K) co-immunoprecipitated with PI 3-kinase and possibly PDK1. The complex possibly possessed a partial basal level of phosphorylation, but not at MAPK sites, which was ..
  22. Peng F, Wang J, Fan W, Meng Y, Li M, Li T, et al. Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia. Oncogene. 2017;: pubmed publisher
    ..This corrects the article DOI: 10.1038/onc.2017.368...
  23. Calleja V, Laguerre M, de Las Heras Martínez G, Parker P, Requejo Isidro J, Larijani B. Acute regulation of PDK1 by a complex interplay of molecular switches. Biochem Soc Trans. 2014;42:1435-40 pubmed publisher
    Phosphoinositide-dependent kinase 1 (PDK1) is the master regulator of at least 23 other AGC kinases whose downstream signalling has often been implicated in various diseases and in particular in cancer...
  24. Jensen C, Buch M, Krag T, Hemmings B, Gammeltoft S, Frodin M. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. J Biol Chem. 1999;274:27168-76 pubmed
    ..Here, we show that the isolated N-terminal kinase of RSK2 (amino acids 1-360) is phosphorylated at Ser(227) by PDK1, a constitutively active kinase, leading to 100-fold stimulation of kinase activity...
  25. Wu D, Huang R, Hamanaka R, Krause M, Oh M, Kuo C, et al. HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. elife. 2017;6: pubmed publisher
    ..Swine aortic arch endothelia exhibited elevated ROS, NOX4, HIF-1α, and glycolytic enzyme and PDK1 expression, suggesting that DF leads to metabolic reprogramming in vivo...
  26. Meng F, Zhang Y, Li X, Wang J, Wang Z. Clinical significance of miR-138 in patients with malignant melanoma through targeting of PDK1 in the PI3K/AKT autophagy signaling pathway. Oncol Rep. 2017;38:1655-1662 pubmed publisher
    ..promoted cell autophagy, induced LC3 protein expression, and suppressed the PI3K/AKT/mTOR signaling pathway and PDK1 protein expression in A2058 cells...
  27. Ezpeleta J, Boudet Devaud F, Pietri M, Baudry A, Baudouin V, Alleaume Butaux A, et al. Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase. Sci Rep. 2017;7:7671 pubmed publisher
    ..depends on PrPC modulation of β1 integrin signaling and downstream activation of ROCK-I and PDK1 kinases...
  28. Seong H, Jung H, Ichijo H, Ha H. Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation. J Biol Chem. 2010;285:2397-414 pubmed publisher
    ..In this study, we reveal a functional association between PDK1 (3-phosphoinositide-dependent protein kinase 1), a critical mediator of cell survival, and ASK1 (apoptosis signal-..
  29. Xu C, Yu L, Hou J, Jackson R, Wang H, Huang C, et al. Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development. Front Cell Neurosci. 2017;11:330 pubmed publisher
    Decreased expression but increased activity of PDK1 has been observed in neurodegenerative disease...
  30. Gudi R, Bowker Kinley M, Kedishvili N, Zhao Y, Popov K. Diversity of the pyruvate dehydrogenase kinase gene family in humans. J Biol Chem. 1995;270:28989-94 pubmed
    Recent evidence from this laboratory indicates that at least two isoenzymic forms of pyruvate dehydrogenase kinase (PDK1 and PDK2) may be involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase complex by ..
  31. Peng Y, Qiu L, Xu D, Zhang L, Yu H, Ding Y, et al. M4IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway. Life Sci. 2017;185:63-72 pubmed publisher
    ..M4IDP treatment increased the expression of PTEN, inhibited the phosphorylation of PDK1, Akt, mTOR, p70S6K, and increased the phosphorylation of GSK-3β and Bad, suggesting that the inhibition of PI3K/..
  32. Xiao Y, Peng H, Hong C, Chen Z, Deng X, Wang A, et al. PDGF Promotes the Warburg Effect in Pulmonary Arterial Smooth Muscle Cells via Activation of the PI3K/AKT/mTOR/HIF-1α Signaling Pathway. Cell Physiol Biochem. 2017;42:1603-1613 pubmed publisher
    ..Treatment with PDGFR antagonists, Warburg effect inhibitor and PDK1 inhibitor significantly inhibited PI3K signaling activation, HIF-1α expression and PASMC proliferation induced by ..
  33. Roelants F, Leskoske K, Martinez Marshall M, Locke M, Thorner J. The TORC2-Dependent Signaling Network in the Yeast Saccharomyces cerevisiae. Biomolecules. 2017;7: pubmed publisher
    ..and requires phosphorylation on its T-loop by eisosome-associated protein kinase Pkh1 (mammalian ortholog is PDK1) and a paralog (Pkh2)...
  34. Goodwin J, Choi H, Hsieh M, Neugent M, Ahn J, Hayenga H, et al. Targeting HIF-1α/PDK1 Axis by Dichloroacetate (DCA) Suppresses Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017;: pubmed publisher
    ..HIF-1α), while overexpression of the critical HIF-1α-mediated glycolytic switch pyruvate dehydrogenase kinase 1 (PDK1) was sufficient to activate glycolysis and potentiate myofibroblast differentiation even in the absence of HIF-1α...
  35. McManus S, Bisson M, Chamberland R, Roy M, Nazari S, Roux S. Autophagy and 3-Phosphoinositide-Dependent Kinase 1 (PDK1)-Related Kinome in Pagetic Osteoclasts. J Bone Miner Res. 2016;31:1334-43 pubmed publisher
    ..Given our previous findings that 3-phosphoinositide-dependent protein kinase 1 (PDK1) associates with the crucial adaptor p62 in OCs, we hypothesized that PDK1 may play an important role in OC-related ..
  36. Kinnaird A, Dromparis P, Saleme B, Gurtu V, Watson K, Paulin R, et al. Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase. Eur Urol. 2016;69:734-744 pubmed publisher
    ..This generic drug has been used in patients for other conditions and thus could be tested in kidney cancer that remains incurable. ..
  37. Seong H, Jung H, Ha H. NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling. J Biol Chem. 2007;282:12075-96 pubmed
    ..These results suggest that the direct interaction of NM23-H1 and STRAP is important for the regulation of TGF-beta-dependent biological activity as well as NM23-H1 activity. ..
  38. Mammano E, Galdi F, Pierobon M, Tessari E, Deng J, Pucciarelli S, et al. Multiplexed protein signal pathway mapping identifies patients with rectal cancer that responds to neoadjuvant treatment. Clin Colorectal Cancer. 2012;11:268-74 pubmed publisher
    ..poor responders; CHK2 and β-catenin were more highly phosphorylated in poor responders, whereas PDK1 and glycogen synthase kinase (GSK)-3α/β had lower phosphorylation levels in poor responders...
  39. Weisberg E, Banerji L, Wright R, Barrett R, Ray A, Moreno D, et al. Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells. Blood. 2008;111:3723-34 pubmed publisher
    ..Finally, BAG956 and rapamycin/RAD001 were shown to combine in a nonantagonistic fashion against BCR-ABL- and mutant FLT3-expressing cells both in vitro and in vivo. ..
  40. Xia S, Chen Z, Forman L, Faller D. PKCdelta survival signaling in cells containing an activated p21Ras protein requires PDK1. Cell Signal. 2009;21:502-8 pubmed publisher
    ..anti-apoptotic signals, is activated by phosphotidylinositol 3' kinase/phosphoinositide-dependent kinase 1 (PI(3)K-PDK1) to deliver the survival signal to Akt in the environment of activated p21(Ras)...
  41. Korotchkina L, Patel M. Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase. J Biol Chem. 2001;276:37223-9 pubmed
    ..site 1 and site 2, however, with different rates in phosphate buffer (for site 1, PDK2 > PDK4 approximately PDK1 > PDK3; for site 2, PDK3 > PDK4 > PDK2 > PDK1). Site 3 was phosphorylated by PDK1 only...
  42. Signore M, Pelacchi F, Di Martino S, Runci D, Biffoni M, Giannetti S, et al. Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo. Cell Death Dis. 2014;5:e1223 pubmed publisher
    ..UCN-01 and demonstrated that the sensitivity to UCN-01 correlates with activation of survival signals mediated by PDK1 and the DNA damage response initiated by CHK1...
  43. Shiu S, Wong Y, Tan K. Effect of advanced glycation end products on lectin-like oxidized low density lipoprotein receptor-1 expression in endothelial cells. J Atheroscler Thromb. 2012;19:1083-92 pubmed
    ..Our results indicated that LOX-1 up-regulation induced by AGE-BSA was a receptor mediated through RAGE and is via the PI3K/PDK1/mTORC2 pathway. Metformincan reduce AGE-stimulated LOX-1 expression in endothelial cells in vitro.
  44. Zurashvili T, Cordón Barris L, Ruiz Babot G, Zhou X, Lizcano J, Gómez N, et al. Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival. Mol Cell Biol. 2013;33:1027-40 pubmed publisher
    3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, ..
  45. Zabkiewicz J, Pearn L, Hills R, Morgan R, Tonks A, Burnett A, et al. The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts. Haematologica. 2014;99:858-64 pubmed publisher
    b>PDK1 is a master kinase that activates at least six protein kinase groups including AKT, PKC and S6K and is a potential target in the treatment of a range of malignancies...
  46. Yang Z, Wu Z, Liu T, Han L, Wang C, Yang B, et al. Upregulation of PDK1 associates with poor prognosis in esophageal squamous cell carcinoma with facilitating tumorigenicity in vitro. Med Oncol. 2014;31:337 pubmed publisher
    3-Phosphoinositide-dependent protein kinase-1 (PDK1) has been reported to be closely correlated with proliferation, apoptosis and invasion of esophageal cancer cells...
  47. Turvey E, Heigenhauser G, Parolin M, Peters S. Elevated n-3 fatty acids in a high-fat diet attenuate the increase in PDH kinase activity but not PDH activity in human skeletal muscle. J Appl Physiol (1985). 2005;98:350-5 pubmed
    ..In addition, our data demonstrated that the hypolipidemic effect of n-3 fatty acids occurs earlier (3 days) than previously reported and is evident even when the diet has 75% of its total energy derived from fat...
  48. Li W, Qian L, Lin J, Huang G, Hao N, Wei X, et al. CD44 regulates prostate cancer proliferation, invasion and migration via PDK1 and PFKFB4. Oncotarget. 2017;8:65143-65151 pubmed publisher
    ..The expression levels of key enzymes in glucose metabolism known as PDK1 and PFKFB4 were determined using QRT-PCR and western blot...
  49. Fencl F, Janda J, Bláhová K, Hríbal Z, Stekrova J, Puchmajerova A, et al. Genotype-phenotype correlation in children with autosomal dominant polycystic kidney disease. Pediatr Nephrol. 2009;24:983-9 pubmed publisher
    ..PKD1 children have more and larger renal cysts, larger kidneys and higher ambulatory BP than do PKD2 children. Renal cysts and enlarged kidneys detected prenatally are highly specific for children with PKD1. ..
  50. Wan X, Liu Y, Zhao Y, Sun X, Fan D, Guo L. Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1α-dependent and -independent mechanism. PLoS ONE. 2017;12:e0184213 pubmed publisher
    ..investigated the intracellular fate of glucose by measuring the gene expression of pyruvate dehydrogenase kinase 1 (PDK1), lactate dehydrogenase (LDHA) and pyruvate dehydrogenase B (PDHB), as well as metabolite levels including lactate ..
  51. Shenoy N, Gleich G, Thomas L. Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway. J Immunol. 2003;171:3734-41 pubmed
    ....
  52. Kolobova E, Tuganova A, Boulatnikov I, Popov K. Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites. Biochem J. 2001;358:69-77 pubmed
    ..four isoenzymes of protein kinase responsible for the phosphorylation and inactivation of pyruvate dehydrogenase (PDK1, PDK2, PDK3 and PDK4) differ in their abilities to phosphorylate the enzyme...
  53. Chen Z, Liu H, Yang H, Gao Y, Zhang G, Hu J. The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer. Onco Targets Ther. 2017;10:3353-3362 pubmed publisher
    ..The correlation of TINCR and PDK1 was identified by real-time PCR and Western blot analysis...
  54. Jeong J, Kim B, Kim D. Ginsenoside Rh1 eliminates the cytoprotective phenotype of human immunodeficiency virus type 1-transduced human macrophages by inhibiting the phosphorylation of pyruvate dehydrogenase lipoamide kinase isozyme 1. Biol Pharm Bull. 2013;36:1088-94 pubmed
    ..On the basis of these findings, we propose that ginsenoside Rh1 could possibly eliminate HIV-1 infected macrophages by inhibiting the PDK1/Akt pathway.
  55. Matsumoto M, Ogawa W, Hino Y, Furukawa K, Ono Y, Takahashi M, et al. Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C. J Biol Chem. 2001;276:14400-6 pubmed
    ..b>PDK1 (3'-phosphoinositide-dependent kinase 1) is thought to participate in Akt activation...
  56. Kim M, Moon J, Kim E, Lee S, Oh J. Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation. Biochem Biophys Res Commun. 2012;421:112-8 pubmed publisher
    ..17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) destabilizes phosphoinositide-dependent kinase-1 (PDK1), an upstream kinase of the protein kinase C-related kinase 2 (PRK2) responsible for phosphorylation of HCV RNA ..
  57. Vallée A, Lecarpentier Y, Guillevin R, Vallee J. Aerobic Glycolysis Hypothesis Through WNT/Beta-Catenin Pathway in Exudative Age-Related Macular Degeneration. J Mol Neurosci. 2017;62:368-379 pubmed publisher
    ..then HIF-1alpha which activates glycolytic enzymes: glucose transporter (Glut), pyruvate dehydrogenase kinase 1 (PDK1), lactate dehydrogenase A (LDH-A), and monocarboxylate lactate transporter (MCT-1)...
  58. Neumann H, Jilg C, Bacher J, Nabulsi Z, Malinoc A, Hummel B, et al. Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany. Nephrol Dial Transplant. 2013;28:1472-87 pubmed publisher
    ..7/100,000 reaching a maximum of 57.3/100,000 in the 6th decade of life. Prevalence of ADPKD is overestimated by 2- to 5-fold and close to the limit of RDs which may be of broad clinical, logistic and policy implications. ..
  59. King C, Gardiner E, Zenke F, Bohl B, Newton A, Hemmings B, et al. p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J Biol Chem. 2000;275:41201-9 pubmed
    In this study, we show that phosphorylated 3-phosphoinositide-dependent kinase 1 (PDK1) phosphorylates p21-activated kinase 1 (PAK1) in the presence of sphingosine...
  60. Huicho L, Xing G, Qualls C, Rivera Ch M, Gamboa J, Verma A, et al. Abnormal energy regulation in early life: childhood gene expression may predict subsequent chronic mountain sickness. BMC Pediatr. 2008;8:47 pubmed publisher
    ..Pyruvate dehydrogenase kinase 1(PDK1) and HIF prolyl hydroxylase 3 (HPH3) mRNA expressions were lowest in children of CMS fathers at altitude...
  61. Li Z, Shen J, Chan M, Wu W. MicroRNA-379 suppresses osteosarcoma progression by targeting PDK1. J Cell Mol Med. 2017;21:315-323 pubmed publisher
    ..Mechanistically, PDK1 was identified as the direct target of miR-379 in osteosarcoma, in which PDK1 expression was up-regulated and ..
  62. Dainichi T, Hayden M, Park S, Oh H, Seeley J, Grinberg Bleyer Y, et al. PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division. Cell Rep. 2016;15:1615-23 pubmed publisher
    ..Here, we report that phosphoinositide-dependent kinase 1 (PDK1) plays a critical role in establishing ACD in the epithelium...