PPAR

Summary

Gene Symbol: PPAR
Description: peroxisome proliferator activated receptor alpha
Alias: NR1C1, PPAR, PPARalpha, hPPAR, peroxisome proliferator-activated receptor alpha, PPAR-alpha, nuclear receptor subfamily 1 group C member 1, peroxisome proliferative activated receptor, alpha, peroxisome proliferator-activated nuclear receptor alpha variant 3
Species: human

Top Publications

  1. pmc Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism
    Sarah Garrido-Urbani
    Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    PLoS ONE 6:e14665. 2011
  2. pmc Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1α and upregulation of peroxisome proliferator-activated receptor-α
    Shouji Matsushima
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Circ Res 112:1135-49. 2013
  3. pmc Peroxisome proliferator-activated receptor (PPAR) gene profiling uncovers insulin-like growth factor-1 as a PPARalpha target gene in cardioprotection
    Hamid el Azzouzi
    Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, 3584 CS Utrecht, The Netherlands
    J Biol Chem 286:14598-607. 2011
  4. doi PPAR-alpha L162V and PGC-1 G482S gene polymorphisms, but not PPAR-gamma P12A, are associated with alcohol consumption in a Spanish Mediterranean population
    F Frances
    Department of Preventive and Legal Medicine, School of Medicine, University of Valencia, Valencia, Spain
    Clin Chim Acta 398:70-4. 2008
  5. ncbi Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle
    Aaron P Russell
    Clinique romande de réadaptation, Suva, Sion, Switzerland Endocrine Unit, University Hospital Geneva, Geneva, Switzerland
    Diabetes 52:2874-81. 2003
  6. ncbi Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element
    Chongren Tang
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge 70808, USA
    J Lipid Res 44:686-95. 2003
  7. ncbi The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human w
    Anne Mazzucotelli
    Institut national de la santé et de la recherche médicale INSERM U858, Obesity Research Laboratory, Toulouse, F 31432, France
    Diabetes 56:2467-75. 2007
  8. pmc RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2
    H Li
    Department of Pharmacology and Molecular Toxicology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0126, USA
    Proc Natl Acad Sci U S A 94:8479-84. 1997
  9. ncbi Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors
    N Masuda
    Department of Life Science, Himeji Institute of Technology, Kamigori, Hyogo 678 1297, Japan
    Gene 221:225-33. 1998
  10. ncbi Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:1645-8. 2002

Research Grants

  1. Min You; Fiscal Year: 2016
  2. Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/Proliferation
    William L Holland; Fiscal Year: 2010
  3. Raphael A Nemenoff; Fiscal Year: 2015
  4. PPAR-gamma ligands in colorectal cancer
    Seung Joon Baek; Fiscal Year: 2010
  5. PPAR gamma regulates vascular endothelial reactive species production in diabetes
    C Michael Hart; Fiscal Year: 2012
  6. Mechanisms of Brd2 immunoprotection from insulin resistance
    Gerald V Denis; Fiscal Year: 2011
  7. Nuclear receptor mechanisms controlling macrophage function in health and disease
    Ajay Chawla; Fiscal Year: 2013
  8. Unique Roles of p160 Coactivators during Human Adipogenesis
    Sean Hartig; Fiscal Year: 2010
  9. Nuclear Receptor Interactions on DNA
    Fraydoon Rastinejad; Fiscal Year: 2010
  10. PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR EXPRESSION
    NICOLAS GUZMAN; Fiscal Year: 2001

Detail Information

Publications243 found, 100 shown here

  1. pmc Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism
    Sarah Garrido-Urbani
    Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    PLoS ONE 6:e14665. 2011
    ..NOX1 silencing decreases endothelial cell migration and tube-like structure formation, through the inhibition of PPARα, a regulator of NF-κB...
  2. pmc Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1α and upregulation of peroxisome proliferator-activated receptor-α
    Shouji Matsushima
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Circ Res 112:1135-49. 2013
    ..The isoform-specific contribution of Nox2 and Nox4 to ischemia/reperfusion (I/R) injury is poorly understood...
  3. pmc Peroxisome proliferator-activated receptor (PPAR) gene profiling uncovers insulin-like growth factor-1 as a PPARalpha target gene in cardioprotection
    Hamid el Azzouzi
    Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, 3584 CS Utrecht, The Netherlands
    J Biol Chem 286:14598-607. 2011
    ..members of the nuclear receptor family of ligand-activated transcription factors and consist of the three isoforms, PPARα, PPARβ/δ, and PPARγ...
  4. doi PPAR-alpha L162V and PGC-1 G482S gene polymorphisms, but not PPAR-gamma P12A, are associated with alcohol consumption in a Spanish Mediterranean population
    F Frances
    Department of Preventive and Legal Medicine, School of Medicine, University of Valencia, Valencia, Spain
    Clin Chim Acta 398:70-4. 2008
    ..However, no studies in humans exist. Our aim is to estimate the possible association between polymorphisms in the PPAR-alpha, PPAR-gamma and PPAR-gamma co-activator 1A (PGC-1A) genes and alcohol consumption in humans.
  5. ncbi Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle
    Aaron P Russell
    Clinique romande de réadaptation, Suva, Sion, Switzerland Endocrine Unit, University Hospital Geneva, Geneva, Switzerland
    Diabetes 52:2874-81. 2003
    The peroxisome proliferator-activated receptor (PPAR)-gamma coactivator-1 (PGC-1) can induce mitochondria biogenesis and has been implicated in the development of oxidative type I muscle fibers...
  6. ncbi Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element
    Chongren Tang
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge 70808, USA
    J Lipid Res 44:686-95. 2003
    ..The WY 14,643 induction of the human Delta-6 desaturase promoter activity was dependent upon the expression of PPARalpha. Electrophoretic mobility shift assays revealed that nuclear proteins extracted from HepG2 cells expressing ..
  7. ncbi The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human w
    Anne Mazzucotelli
    Institut national de la santé et de la recherche médicale INSERM U858, Obesity Research Laboratory, Toulouse, F 31432, France
    Diabetes 56:2467-75. 2007
    ..the pattern of genes regulated by peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1 alpha (PGC-1 alpha) in human adipocytes and the involvement of PPARalpha and PPARgamma in PGC-1 alpha transcriptional action.
  8. pmc RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2
    H Li
    Department of Pharmacology and Molecular Toxicology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0126, USA
    Proc Natl Acad Sci U S A 94:8479-84. 1997
    ..Thus, RAC3 is a member of a growing coactivator network that should be useful as a tool for understanding hormone action and as a target for developing new therapeutic agents that can block hormone-dependent neoplasia...
  9. ncbi Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors
    N Masuda
    Department of Life Science, Himeji Institute of Technology, Kamigori, Hyogo 678 1297, Japan
    Gene 221:225-33. 1998
    ..receptor (PPAR), a rat liver cDNA library was screened by a yeast two-hybrid system, using the mouse PPARalpha as a bait...
  10. ncbi Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:1645-8. 2002
    ..HCF is shown to bind to both PGC-1alpha and -1beta and augment their transcriptional activity...
  11. ncbi Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol
    Hiroki Ishiguro
    Department of Medical Genetics, Institute of Basic Medical Science, University of Tsukuba, Ibaraki, Japan
    Am J Med Genet 114:15-23. 2002
    ..3, the NURR1 gene (NR4A2) on chromosome 2q22-q23, and the PPAR alpha gene (PPARA) on chromosome 22q12.2-13.1...
  12. doi Liver-specific peroxisome proliferator-activated receptor alpha target gene regulation by the angiotensin type 1 receptor blocker telmisartan
    Markus Clemenz
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Str 3 4, 10115 Berlin, Germany
    Diabetes 57:1405-13. 2008
    ..investigates the molecular mechanisms of telmisartans hypolipidemic actions, in particular its effect on the PPARalpha pathway...
  13. doi Thioredoxin-1 and its natural inhibitor, vitamin D3 up-regulated protein 1, are differentially regulated by PPARalpha in human macrophages
    Ludivine Billiet
    UMR 7079, Université Pierre et Marie Curie CNRS, Batiment A, 5ème étage Case courrier 256, 7, quai St Bernard, 75252 Paris Cedex 5, France
    J Mol Biol 384:564-76. 2008
    ..Peroxisome proliferator-activated receptor-alpha (PPARalpha) is expressed by human macrophages and exhibits anti-inflammatory properties...
  14. pmc Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalpha-mediated activation of the brown-fat-specific UCP-1 gene
    Wei Chen
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Mol Cell 35:755-68. 2009
    ..These results indicate dynamic MED1-dependent PGC-1alpha interactions related to functions in both chromatin remodeling and the transition to subsequent transcription initiation...
  15. ncbi Genetic determinants of the response to bezafibrate treatment in the lower extremity arterial disease event reduction (LEADER) trial
    Y Jamshidi
    Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, The Rayne Institute, London, UK
    Atherosclerosis 163:183-92. 2002
    ..Three polymorphisms in the peroxisome proliferator activated receptor alpha (PPARalpha) gene were investigated (L162V, G>A in intron 2 and G>C in intron 7), two in ..
  16. ncbi Molecular characterisation of six alternatively spliced variants and a novel promoter in human peroxisome proliferator-activated receptor alpha
    Choy Hoong Chew
    School of Biological Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia, Japan
    Biochem Biophys Res Commun 305:235-43. 2003
    Peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcriptional factor that governs many biological processes, including lipid metabolism, inflammation, and atherosclerosis...
  17. ncbi Association of V227A PPARalpha polymorphism with altered serum biochemistry and alcohol drinking in Japanese men
    Hisao Naito
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pharmacogenet Genomics 16:569-77. 2006
    ..The two-fold objective of our study was to determine the presence of PPARalpha polymorphisms and their frequencies in Japanese populations and then to evaluate the effects of any alleles on ..
  18. ncbi PPARalpha transcriptionally induces AhR expression in Caco-2, but represses AhR pro-inflammatory effects
    P H Villard
    INSERM, U476 Nutrition Humaine et Lipides, Marseille F 13385, France
    Biochem Biophys Res Commun 364:896-901. 2007
    In this work we demonstrate that Caco-2 cell treatment with WY-14643 (a potent PPARalpha agonist) causes an increase in AhR expression...
  19. ncbi Structural insight into the crucial role of ligand chirality in the activation of PPARs by crystallographic methods
    F Loiodice
    Dipartimento Farmaco Chimico, Università degli Studi di Bari A Moro, Via Orabona 4, 70126 Bari, Italia
    Curr Top Med Chem 11:819-39. 2011
    ..This review provides an overview of most papers reporting the influence of stereochemistry on PPAR activation...
  20. ncbi cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor
    T Sher
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892
    Biochemistry 32:5598-604. 1993
    The human peroxisome proliferator activated receptor (hPPAR) was cloned from a human liver cDNA library. The cDNA exhibited 85% and 91% DNA and deduced amino acid sequence identity with mouse PPAR (mPPAR), respectively...
  21. ncbi Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha
    H Eric Xu
    Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Nature 415:813-7. 2002
    ..Biochemical analyses and structure-based mutagenesis indicate that this mode of co-repressor binding is highly conserved across nuclear receptors...
  22. ncbi Effect of apolipoprotein E, peroxisome proliferator-activated receptor alpha and lipoprotein lipase gene mutations on the ability of fenofibrate to improve lipid profiles and reach clinical guideline targets among hypertriglyceridemic patients
    Diane Brisson
    Community Genomic Medicine Centre, University of Montreal, Chicoutimi Hospital, Quebec, Canada
    Pharmacogenetics 12:313-20. 2002
    Fenofibrate is a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist which regulates the transcription of genes encoding proteins involved in triglyceride (TG)-rich lipoproteins and lipoprotein lipase (LPL) metabolism...
  23. ncbi Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes
    Christelle Foucher
    Laboratoires Fournier S A Centre de Recherches, Department of Clinical Research and Medical Affairs, Daix, France
    Pharmacogenetics 14:823-9. 2004
    ....
  24. ncbi Peroxisome proliferator-activated receptor alpha gene variation influences age of onset and progression of type 2 diabetes
    David M Flavell
    Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, London, UK
    Diabetes 54:582-6. 2005
    ..Peroxisome proliferator-activated receptor (PPAR)alpha is a master regulator of fatty acid catabolism, and PPARalpha activators delay the onset of type 2 diabetes...
  25. ncbi Contemporaneous carrier-state of two or three "proatherosclerotic" variants of APOE, ICAM1, PPARA and PAI-1 genes differentiate CAD patients from healthy individuals
    Iwona Zak
    Department of Biochemistry and Medical Genetics, Medical University of Silesia, Katowice, Poland
    Clin Chim Acta 362:110-8. 2005
    ....
  26. ncbi [The association of gene polymorphisms with the muscle fiber type composition]
    I I Akhmetov
    Ross Fiziol Zh Im I M Sechenova 92:883-8. 2006
    ..DNA was obtained from mouthwash samples by alkaline extraction. Polymorphism determination of PPARalpha, ACE and ACTN3 genes was performed using polymerase chain raction. Muscle fiber typing from m...
  27. pmc Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke
    Daniel A Enquobahrie
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Am J Cardiol 101:1683-8. 2008
    ..77 to 0.99). No within-gene or gene-gene interaction was associated with MI or ischemic stroke risk. In conclusion, potential SNP-disease associations identified in the present study are novel and need further investigation...
  28. doi The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes
    Ildus I Ahmetov
    Laboratory of Muscle Performance, SSC RF Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
    Hum Genet 126:751-61. 2009
    ..46; P = 7.0 × 10(-4)). These data suggest that the likelihood of becoming an elite endurance athlete depends on the carriage of a high number of endurance-related alleles...
  29. doi Variation in the PPARα gene in Polish rowers
    Agnieszka Maciejewska
    Department of Genetics, University of Szczecin, Poland
    J Sci Med Sport 14:58-64. 2011
    The PPARα gene code for transcriptional factor that is a central regulator of expression of genes involved in fatty acid metabolism and is believed to be a one of the genes of health-related fitness phenotype...
  30. doi PPARα polymorphisms as risk factors for dyslipidemia in a Brazilian population
    Diego Robles Mazzotti
    Disciplina de Genetica, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo, Rua Botucatu 740, Edifício Leitão da Cunha, Sao Paulo SP, Brazil
    Mol Genet Metab 102:189-93. 2011
    ....
  31. doi Gene-gene interactions among PPARα/δ/γ polymorphisms for hypertriglyceridemia in Chinese Han population
    Shu Jun Gu
    Department of Epidemiology, School of Public Health, Soochow University, Suzhou, Jiangsu 215123, China
    Gene 515:272-6. 2013
    ..and multilocus interactions among genetic variants in Chinese Han individuals to test the hypothesis that PPAR-α/δ/γ polymorphisms may contribute to the etiology of hypertriglyceridemia independently and/or through such ..
  32. ncbi Peroxisome proliferator-activated receptors: structures and function
    J D Tugwood
    Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, United Kingdom
    Ann N Y Acad Sci 804:252-65. 1996
    ..There is a wealth of data to implicate the peroxisome proliferator-activated receptor alpha (PPAR alpha) in mediating these effects in rodent species; PPAR alpha is expressed in tissues that show physiological ..
  33. pmc Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
    S A Kliewer
    Department of Molecular Endocrinology, Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 94:4318-23. 1997
    ..Here, we describe a novel fibrate, designated GW2331, that is a high-affinity ligand for both PPARalpha and PPARgamma...
  34. ncbi Expression of peroxisome proliferator-activated receptor alpha (PPAR alpha) in primary cultures of human vascular endothelial cells
    I Inoue
    Fourth Department of Medicine, Saitama Medical School, Japan
    Biochem Biophys Res Commun 246:370-4. 1998
    ..Three types of PPARs have been described in humans: PPAR alpha, PPAR beta, and PPAR gamma...
  35. ncbi Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages
    G Chinetti
    U 325 INSERM, Departement d Atherosclerose, Institut Pasteur, 1 rue Calmette, 59019 Lille, France
    J Biol Chem 273:25573-80. 1998
    ..Here, we show that the PPARalpha and PPARgamma forms are expressed in differentiated human monocyte-derived macrophages, which participate in ..
  36. ncbi Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis
    P Costet
    Laboratoire de Pharmacologie et Toxicologie, INRA, BP 3, 31931 Toulouse, Cedex 09 France
    J Biol Chem 273:29577-85. 1998
    The alpha-isoform of the peroxisome proliferator-activated receptor (PPARalpha) is a nuclear transcription factor activated by structurally diverse chemicals referred to as peroxisome proliferators...
  37. ncbi Phytanic acid activates the peroxisome proliferator-activated receptor alpha (PPARalpha) in sterol carrier protein 2-/ sterol carrier protein x-deficient mice
    P Ellinghaus
    Institut für Arterioskleroseforschung, D 48129 Munster, Germany
    J Biol Chem 274:2766-72. 1999
    ..been demonstrated to be transcriptionally regulated by the peroxisome proliferator-activated receptor alpha (PPARalpha)...
  38. ncbi Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain
    C E Juge-Aubry
    Division of Endocrinology and Diabetes, University Hospital Geneva, CH 1211 Geneva 14, Switzerland
    J Biol Chem 274:10505-10. 1999
    ..In addition, they are subject to phosphorylation by insulin, resulting in the activation of PPARalpha, while inhibiting PPARgamma under certain conditions...
  39. ncbi Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein
    P Dowell
    Program in Molecular and Cellular Biology, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA
    J Biol Chem 274:15901-7. 1999
    ..corepressor (NCoR) was demonstrated to interact strongly with peroxisome proliferator-activated receptor alpha (PPARalpha), and PPARalpha ligands suppressed this interaction...
  40. pmc A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders
    T C Leone
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:7473-8. 1999
    ..that the lipid-activated transcription factor, the peroxisome proliferator-activated receptor alpha (PPARalpha), plays a pivotal role in the cellular metabolic response to fasting...
  41. ncbi Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1
    P Delerive
    INSERM U325, Departement d Atherosclerose, Institut Pasteur de Lille, 1 rue Pr Calmette 59019 Lille, France
    J Biol Chem 274:32048-54. 1999
    ..We have previously reported that peroxisome proliferator-activated receptor alpha (PPARalpha) ligands (fibrates) lower elevated plasma concentrations of IL-6 in patients with atherosclerosis and inhibit IL-..
  42. pmc The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    R B Vega
    Center for Cardiovascular Research, Departments of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 20:1868-76. 2000
    Peroxisome proliferator-activated receptor alpha (PPARalpha) plays a key role in the transcriptional control of genes encoding mitochondrial fatty acid beta-oxidation (FAO) enzymes...
  43. ncbi The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants
    A Sapone
    Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland 20892, USA
    Pharmacogenetics 10:321-33. 2000
    ..effect of the null phenotype in development and reproduction opens up the possibility for null or variant PPARalpha gene (PPARA) alleles in humans...
  44. ncbi Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease
    C Lacquemant
    Institute of Biology, CNRS UPRES A 8090, and Pasteur Institute of Lille, 1 rue du Pr Calmette, B P 245, 59019 Lille Cedex, France
    Diabetes Metab 26:393-401. 2000
    The peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily...
  45. ncbi Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family
    P Cronet
    Department of Molecular Biology, AstraZeneca R and D Molndal, S 431 83, Molndal, Sweden
    Structure 9:699-706. 2001
    ..The roles of PPARalpha in fatty acid oxidation and PPARgamma in adipocyte differentiation and lipid storage have been characterized ..
  46. pmc Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors
    H E Xu
    Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 98:13919-24. 2001
    ..We report the x-ray crystal structure of the ligand binding domain of PPAR alpha (NR1C1) as a complex with the agonist ligand GW409544 and a coactivator motif from the steroid receptor ..
  47. ncbi The mechanisms of action of PPARs
    Joel Berger
    Department of Molecular Endocrinology, Merck Research Laboratories, P O Box 2000, Rahway, New Jersey 07065, USA
    Annu Rev Med 53:409-35. 2002
    ..peroxisome proliferator-activated receptors (PPARs) are a group of three nuclear receptor isoforms, PPAR gamma, PPAR alpha, and PPAR delta, encoded by different genes...
  48. ncbi Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension
    Yalda Jamshidi
    Centre for Cardiovascular Genetics, Department of Medicine, University College London Medical School, London, UK
    Circulation 105:950-5. 2002
    ..Peroxisome proliferator--activated receptor alpha (PPARalpha) regulates genes responsible for myocardial fatty acid oxidation and is downregulated during cardiac hypertrophy,..
  49. ncbi Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease
    David M Flavell
    Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College of London Medical School, London, UK
    Circulation 105:1440-5. 2002
    Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates the expression of genes involved in lipid metabolism and inflammation, making it a candidate gene for atherosclerosis and ischemic heart disease (IHD).
  50. ncbi Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity
    Takeya Tsutsumi
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Hepatology 35:937-46. 2002
    ..activity regulated by the RXRalpha homodimer as well as by the heterodimer with peroxisome proliferator activated receptor alpha. Furthermore, expression of the CRBPII gene is also up-regulated in the livers of HCV core-..
  51. pmc PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis
    Nikolaus Marx
    Department of Internal Medicine II, University of Ulm, Ulm, Germany
    Circ Res 90:703-10. 2002
    ..Isolated human CD4-positive T cells express PPARalpha and PPARgamma mRNA and protein...
  52. ncbi Characterization of the human PPARalpha promoter: identification of a functional nuclear receptor response element
    Ines Pineda Torra
    U 545 Institut National de la Santé et de la Recherche Médicale, Departement d Atherosclerose, Institut Pasteur de Lille, 59019 Lille, France
    Mol Endocrinol 16:1013-28. 2002
    b>PPARalpha is a nuclear receptor that controls lipid and glucose metabolism and exerts antiinflammatory activities. The factors regulating human PPARalpha (hPPARalpha) gene expression remain largely unexplored...
  53. ncbi Association between the PPARA L162V polymorphism and plasma lipid levels: the Framingham Offspring Study
    E S Tai
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Arterioscler Thromb Vasc Biol 22:805-10. 2002
    Peroxisome proliferator activated receptor (PPAR) alpha is a member of the nuclear receptor superfamily that regulates key proteins involved in fatty acid oxidation, extracellular lipid metabolism, hemostasis, and inflammation...
  54. pmc Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator
    Sailesh Surapureddi
    Department of Pathology, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 99:11836-41. 2002
    Peroxisome proliferator-activated receptor alpha (PPAR alpha) plays a central role in the cell-specific pleiotropic responses induced by structurally diverse synthetic chemicals designated as peroxisome proliferators...
  55. ncbi Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231
    Kate M Suchanek
    School of Pharmacy, University of Queensland, St Lucia, Australia
    Mol Carcinog 34:165-71. 2002
    ..It has been suggested that PPARalpha mRNA expression levels are an important determinant of rodent hepatic tumorigenicity...
  56. ncbi The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element
    Xavier Prieur
    GlaxoSmithKline, 25 Avenue du Quebec, 91951 Les Ulis Cedex, France
    J Biol Chem 278:25468-80. 2003
    ..Since the peroxisome proliferator-activated receptor-alpha (PPARalpha) and the farnesoid X-activated receptor (FXR) have been shown to modulate the expression of genes involved in ..
  57. ncbi The peroxisome proliferator-activated receptor alpha L162V mutation is associated with reduced adiposity
    Yohan Bosse
    Lipid Research Center, Laval University Medical Research Center, Sainte Foy, Quebec, Canada
    Obes Res 11:809-16. 2003
    To determine the contribution of the peroxisome proliferator-activated receptor alpha (PPARalpha) L162V mutation to the variation of several indexes of body fatness obtained from healthy adults who participated in the Quebec Family Study.
  58. ncbi Peroxisome proliferator-activated receptor alpha target genes
    S Mandard
    Nutrition, Metabolism and Genomics Group, Wageningen University, 6700 Wageningen, The Netherlands
    Cell Mol Life Sci 61:393-416. 2004
    ..Here we review the involvement of PPARalpha in peroxisomal and mitochondrial fatty acid oxidation, microsomal fatty acid hydroxylation, lipoprotein, bile ..
  59. ncbi Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study
    Suetnee Chen
    Sections of Cardiology and Atherosclerosis, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Pharmacogenetics 14:61-71. 2004
    ..372 Lipoprotein and Coronary Atherosclerosis Study subjects for seven single nucleotide polymorphisms (SNPs) in PPARalpha (-35 089A>C, 484C>G), delta (-4401C>T, 294T>C) and gamma (34C>G, 25 506C>T, 161C>T) by ..
  60. ncbi The protein kinase C signaling pathway regulates a molecular switch between transactivation and transrepression activity of the peroxisome proliferator-activated receptor alpha
    Christophe Blanquart
    UR 545 Institut National de la Santé et de la Recherche Médicale, Departement d Atherosclerose, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille, France
    Mol Endocrinol 18:1906-18. 2004
    ..b>PPARalpha is activated by natural fatty acids and synthetic compounds like fibrates...
  61. ncbi Association between the PPARalpha-L162V polymorphism and components of the metabolic syndrome
    Julie Robitaille
    Lipid Research Center, CHUQ CHUL Pavilion, 2705 Laurier Blvd, TR 93, G1V 4G2, Ste Foy, QC, Canada
    J Hum Genet 49:482-9. 2004
    ..The PPARalpha-L162V genotype was determined in a sample of 632 men by a polymerase chain reaction-restriction length ..
  62. pmc Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle
    Janice M Huss
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 24:9079-91. 2004
    ..Many of the genes regulated by ERRalpha are known targets for the nuclear receptor PPARalpha, and therefore, the interaction between these regulatory pathways was explored...
  63. ncbi Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites
    E Seree
    FRE Centre National de la Recherche Scientifique, Faculte de Pharmacie, Marseille, France
    Gastroenterology 127:1436-45. 2004
    ..The aim of this work was to study the role of peroxisome proliferator-activated receptors in cytochrome P450 1A1 gene induction...
  64. ncbi The peroxisome proliferator-activated receptor alpha Leu162Val polymorphism influences the metabolic response to a dietary intervention altering fatty acid proportions in healthy men
    Ann Marie Paradis
    Lipid Research Center and the Molecular Endocrinology and Oncology Laboratory Research Center, CHUQ CHUL Pavilion, Sainte Foy, Canada
    Am J Clin Nutr 81:523-30. 2005
    ..Serum lipid responses to dietary modification are partly determined by genetic factors...
  65. ncbi Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study
    E Shyong Tai
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    J Nutr 135:397-403. 2005
    Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear transcription factor regulating multiple genes involved in lipid metabolism...
  66. ncbi The conserved residue Phe273(282) of PPARalpha(gamma), beyond the ligand-binding site, functions in binding affinity through solvation effect
    Liduo Yue
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    Biochimie 87:539-50. 2005
    ..Residue Phe282 in PPARgamma (Phe273 in PPARalpha), beyond the ligand-binding site, is a conserved amino acid across several nuclear receptors and in all PPAR ..
  67. pmc Association of common variation in the PPARA gene with incident myocardial infarction in individuals with type 2 diabetes: a Go-DARTS study
    Alex S F Doney
    The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland, UK
    Nucl Recept 3:4. 2005
    ..Cox's proportional hazards was used to interrogate time to event from recruitment, and linear regression for analysing association of genotype with quantitative clinical traits...
  68. pmc Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis
    Keiichirou Morimura
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 27:1074-80. 2006
    ..such as lipid-lowering fibrate drugs, are agonists for the peroxisome proliferator-activated receptor alpha (PPARalpha). Sustained activation of PPARalpha leads to the development of liver tumors in rodents...
  69. ncbi PPARalpha gene variation and physical performance in Russian athletes
    Ildus I Ahmetov
    Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia
    Eur J Appl Physiol 97:103-8. 2006
    Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates genes responsible for skeletal and heart muscle fatty acid oxidation...
  70. pmc Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis
    Philippe Lefebvre
    Departement d Atherosclerose, Institut Pasteur de Lille, INSERM U545, and Université de Lille 2, Lille, France
    J Clin Invest 116:571-80. 2006
    b>PPARalpha is a nuclear receptor that regulates liver and skeletal muscle lipid metabolism as well as glucose homeostasis...
  71. ncbi Relationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people
    Thomas Sparsø
    Steno Diabetes Center, 521, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Mol Genet Metab 90:205-9. 2007
    Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a nuclear receptor capable of regulating the expression of genes involved in peroxisomal and mitochondrial beta-oxidation pathways...
  72. ncbi Analysis of PPAR alpha function in human kidney cell line using siRNA
    Keisuke Tachibana
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nucleic Acids Symp Ser (Oxf) . 2006
    ..b>PPARalpha is mainly expressed in the liver, kidney, heart and muscle...
  73. ncbi Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha
    Valerie Y Ng
    Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, CA 94143 2911, USA
    Drug Metab Dispos 35:1126-34. 2007
    ..acids (DHETs), are induced upon activation of peroxisome proliferator-activated receptor alpha (PPARalpha) by fatty acids and fibrates...
  74. ncbi [Association of regulatory genes polymorphisms with aerobic and anaerobic performance of athletes]
    I I Akhmetov
    Ross Fiziol Zh Im I M Sechenova 93:837-43. 2007
    ..Thus, PPARA G, PPARG Ala, PPARD C and PGCIA Gly alleles can be considered as genetic markers associated with enhanced physical performance...
  75. ncbi Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid beta-oxidation: functional role of peroxisome proliferator activated receptor alpha in human peripheral blood mononuclear cells
    Mark Bouwens
    Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Am J Clin Nutr 86:1515-23. 2007
    ..are nutrients that regulate gene expression by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). PBMCs express PPARalpha, making these cells interesting to study FA-dependent gene expression.
  76. pmc Polymorphisms in the peroxisome proliferator activated receptor alpha gene are associated with levels of apolipoprotein CIII and triglyceride in African-Americans but not Caucasians
    Min Jeong Shin
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Atherosclerosis 198:313-9. 2008
    We tested whether single nucleotide polymorphisms (SNPs) in the PPARalpha gene (PPARA) are associated with variations in levels of plasma apolipoprotein CIII (apoCIII) levels, as well as other lipids and lipoproteins, in African-..
  77. doi Association between PPARalpha gene polymorphisms and myocardial infarction
    Wibke Reinhard
    Klinik und Poliklinik fur Innere Medizin II, Universitatsklinikum Regensburg, Regensburg, Germany
    Clin Sci (Lond) 115:301-8. 2008
    b>PPARalpha (peroxisome-proliferator-activated receptor alpha) regulates the expression of genes that are involved in lipid metabolism, tissue homoeostasis and inflammation...
  78. doi Single gene contributions: genetic variants of peroxisome proliferator-activated receptor (isoforms alpha, beta/delta and gamma) and mechanisms of dyslipidemias
    Eu Leong Yong
    Department of Obstetrics and Gynecology, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore
    Curr Opin Lipidol 19:106-12. 2008
    ..Polymorphisms in peroxisome proliferator-activated receptor isoforms may be among the most important single-gene contributors to dyslipidemias, insulin resistance, and maturity-onset diabetes...
  79. pmc Peroxisome proliferator-activated receptor [alpha] genetic variation interacts with n-6 and long-chain n-3 fatty acid intake to affect total cholesterol and LDL-cholesterol concentrations in the Atherosclerosis Risk in Communities Study
    Kelly A Volcik
    Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, USA
    Am J Clin Nutr 87:1926-31. 2008
    ..The binding of polyunsaturated fatty acids (PUFAs) to PPARA results in rapid changes in the expression of genes involved in lipid oxidation, with long-chain n-3 fatty acids being potent activators of PPARA...
  80. doi A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio
    Shaohua Chen
    Zhejiang University, College of Medicine, The First Affiliated Hospital, Gastroenterology, Zhejiang, China
    J Gastroenterol Hepatol 23:1415-8. 2008
    This study analyzes the effect of the val227ala variant of the peroxisome proliferators-activated receptor-alpha (PPAR-alpha) on non-alcoholic fatty liver disease.
  81. pmc Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes
    Sharon Cresci
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8086, Saint Louis, MO 63110 1093, USA
    Pharmacogenomics 9:1403-17. 2008
    ..ischemia and BB influence metabolic processes regulated by peroxisome proliferator-activated receptor alpha (PPARalpha), we hypothesized that interactions between polymorphisms of the PPARalpha gene (PPARA) and BB treatment would ..
  82. doi Chlamydia pneumoniae induces macrophage-derived foam cell formation via PPAR alpha and PPAR gamma-dependent pathways
    Chun li Mei
    Department of Gerontology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
    Cell Biol Int 33:301-8. 2009
    ..This study therefore investigated the role that PPAR alpha and PPAR gamma may play a role in C. pneumoniae-induced foam cell formation...
  83. doi Peroxisome proliferator-activated receptor-alpha (PPARalpha): at the crossroads of obesity, diabetes and cardiovascular disease
    Jean Charles Fruchart
    Laboratoire J and K, INSERM UR 545, Universite Lille 2, Faculte de Medecine de Lille, Pole Recherche, Lille Cedex, France
    Atherosclerosis 205:1-8. 2009
    ..Peroxisome proliferator-activated receptor alpha (PPARalpha), a member of this nuclear receptor family, has emerged as an important player in this scenario, with evidence ..
  84. doi Do PPARGC1A and PPARalpha polymorphisms influence sprint or endurance phenotypes?
    N Eynon
    Genetics and Molecular Biology Laboratory, Life Sciences Division, The Zinman College of Physical Education and Sport Sciences at the Wingate Institute, Netanya, Israel
    Scand J Med Sci Sports 20:e145-50. 2010
    ..receptor gamma coactivator1 (PPARGC1A) and Peroxisome proliferator-activated receptor alpha (PPARalpha) genes, respectively, have been associated with mRNA and protein activity...
  85. doi Association of PPARalpha gene polymorphisms and lipid serum levels in a Brazilian elderly population
    Elizabeth Suchi Chen
    Genetics Division, Department of Morphology and Genetics, Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil
    Exp Mol Pathol 88:197-201. 2010
    Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear transcription factor strictly involved in lipid and lipoprotein metabolisms...
  86. doi Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes
    Carole Ribet
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 858, 1 Avenue Jean Pouilhès, BP 84225, 31432 Toulouse Cedex 4, France
    Endocrinology 151:123-33. 2010
    ..of peroxisome proliferator-activated receptors (PPAR)alpha in human white adipocyte metabolism and at comparing PPAR alpha and PPAR gamma actions in these cells...
  87. pmc PPARalpha: energy combustion, hypolipidemia, inflammation and cancer
    Sean R Pyper
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Nucl Recept Signal 8:e002. 2010
    The peroxisome proliferator-activated receptor alpha (PPARalpha, or NR1C1) is a nuclear hormone receptor activated by a structurally diverse array of synthetic chemicals known as peroxisome proliferators...
  88. doi Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells
    Marina Maggiora
    Dipartimento di Medicina ed Oncologia Sperimentale, Universita di Torino, Corso Raffaello, Turin, Italy
    Cell Biochem Funct 28:571-7. 2010
    ..Among peroxisome proliferators, fibrate derivatives are considered specific ligands for PPARα, whereas eicosanoids, such as PGJ2, for PPARγ...
  89. pmc Activation of peroxisome proliferator-activated receptor α (PPARα) suppresses hypoxia-inducible factor-1α (HIF-1α) signaling in cancer cells
    Jundong Zhou
    Department of Radio Oncology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 205123, China
    J Biol Chem 287:35161-9. 2012
    Activation of peroxisome proliferator-activated receptor α (PPARα) has been demonstrated to inhibit tumor growth and angiogenesis, yet the mechanisms behind these actions remain to be characterized...
  90. ncbi A polymorphism, L162V, in the peroxisome proliferator-activated receptor alpha (PPARalpha) gene is associated with lower body mass index in patients with non-insulin-dependent diabetes mellitus
    D Evans
    Klinik und Poliklinik für Innere Medizin, Universitätsklinikum Eppendorf, Hamburg, Germany
    J Mol Med (Berl) 79:198-204. 2001
    ..The frequency of the L162V polymorphism in the PPARalpha gene was determined in 370 morbidly obese patients who underwent gastric banding surgery, 154 patients attending ..
  91. ncbi Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects
    Eva Maria D Nielsen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Copenhagen, Denmark
    Pharmacogenetics 13:417-23. 2003
    ..the study was to investigate whether genetic variation in the peroxisome proliferator-activated receptor-alpha (PPARalpha) is associated with type 2 diabetes and altered lipid or carbohydrate metabolism in glucose tolerant subjects...
  92. ncbi The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women
    Edmund Chan
    Department of Endocrinology, Singapore General Hospital, Block 6 level 6, Room B35, Outram Road, Singapore 169608, Republic of Singapore
    Atherosclerosis 187:309-15. 2006
    Peroxisome proliferators activated receptor alpha (PPARalpha) regulates the transcription of several proteins involved in human lipoprotein metabolism...
  93. ncbi Combined simulation and mutagenesis analyses reveal the involvement of key residues for peroxisome proliferator-activated receptor alpha helix 12 dynamic behavior
    Liliane Michalik
    Center for Integrative Genomics and National Research Center Frontiers in Genetics, University of Lausanne, Le Génopode, CH 1015 Lausanne, Switzerland
    J Biol Chem 282:9666-77. 2007
    ..well as the involvement of individual residues with regard to peroxisome proliferator-activated receptor alpha (PPARalpha) constitutive and ligand-dependent transcriptional activity...
  94. ncbi Association between the PPARalpha L162V polymorphism, plasma lipoprotein levels, and atherosclerotic disease in patients with diabetes mellitus type 2 and in nondiabetic controls
    Ioanna Gouni-Berthold
    Second Department of Internal Medicine, University of Cologne and Center of Molecular Medicine Cologne CMMC, Cologne, Germany
    Am Heart J 147:1117-24. 2004
    b>Peroxisome proliferator activated receptor alpha (PPARalpha) regulates genes involved in lipoprotein metabolism, hemostasis, and inflammation...
  95. ncbi Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells
    Patrizia Rise
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Eur J Pharmacol 571:97-105. 2007
    ..Both PPARalpha (WY 14643 and fenofibrate) and PPARgamma (ciglitazone) agonists did not affect linoleic acid conversion and the ..
  96. ncbi Species differences in sequence and activity of the peroxisome proliferator response element (PPRE) within the acyl CoA oxidase gene promoter
    K G Lambe
    Cancer Biology Group, AstraZeneca Central Toxicology Laboratory, Macclesfield, UK
    Toxicol Lett 110:119-27. 1999
    ..PPs activate the peroxisome proliferator activated receptor alpha (PPARalpha) that binds to DNA at peroxisome proliferator response elements (PPREs) within the ..
  97. ncbi Role of thyroid hormones in hepatic effects of peroxisome proliferators
    R T Miller
    College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Toxicol Pathol 29:149-55. 2001
    ..Although the receptor that mediates key hepatic effects, the peroxisome proliferator-activated receptor alpha (PPAR-alpha), and its endogenous ligands have been identified, the mechanism whereby these commonly used chemicals cause ..
  98. ncbi Effect of clofibrate on malic enzyme and leptin mRNAs level in rat brown and white adipose tissue
    Z Kochan
    Department of Biochemistry, Medical University of Gdansk, Poland
    Horm Metab Res 31:538-42. 1999
    ..results presented in this paper provide further evidence that the clofibrate (activator of peroxisome proliferator activated receptor alpha), feeding is without effect on ob gene expression in rat white and brown adipose tissue...
  99. ncbi Peroxisome proliferator-activated receptors, coactivators, and downstream targets
    C Qi
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Cell Biochem Biophys 32:187-204. 2000
    ..The induction of peroxisome proliferation is mediated by PP-activated receptor alpha (PPAR alpha), a member of a group of transcription factors that regulate the expression of genes associated with lipid ..
  100. ncbi Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes
    A Ibabe
    Biologia Zelularra eta Histologia Laborategia, Zoologia eta Animali Biologia Zelularra Saila, Zientzia eta Teknologia Fakultatea, Euskal Herriko Unibertsitatea Universidad del País Vasco, 644 PK, Bilbao E 48080, Basque Country, Spain
    Toxicol In Vitro 19:725-35. 2005
    ..proliferators and is regulated through a nuclear receptor named peroxisome proliferator-activated receptor (PPAR). PPAR family members exhibit a strong binding affinity for both saturated and unsaturated fatty acids...
  101. pmc Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons
    Alexander Tenenbaum
    Cardiac Rehabilitation Institute, Sheba Medical Center, 52621 Tel Hashomer, Israel
    Cardiovasc Diabetol 4:14. 2005
    There are three peroxisome proliferator-activated receptors (PPARs) subtypes which are commonly designated PPAR alpha, PPAR gamma and PPAR beta/delta...

Research Grants81

  1. Min You; Fiscal Year: 2016
    ..sterol regulatory element binding protein 1 (SREBP-1), peroxisome proliferator-activated receptor alpha (PPAR-alpha) and PPAR-gamma co-activator-alpha (PGC-1-alpha...
  2. Synergistic Roles of Adiponectin & PPARgamma in Beta-Cell Survival/Proliferation
    William L Holland; Fiscal Year: 2010
    ..agents which improves insulin sensitivity through activation of peroxisome proliferator-activated receptor-gamma (PPAR gamma), a critical transcriptional mediator of adipocyte differentiation...
  3. Raphael A Nemenoff; Fiscal Year: 2015
    ..Peroxisome proliferator-activated receptor-? (PPAR?), a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors, plays a critical ..
  4. PPAR-gamma ligands in colorectal cancer
    Seung Joon Baek; Fiscal Year: 2010
    ..IV. To investigate the in vivo anti-tumorigenic effects of a novel PPARy ligand, MCC-555, and its affects on NAG-1 expression at different stages of colorectal carcinogenesis. ..
  5. PPAR gamma regulates vascular endothelial reactive species production in diabetes
    C Michael Hart; Fiscal Year: 2012
    ..abstract_text> ..
  6. Mechanisms of Brd2 immunoprotection from insulin resistance
    Gerald V Denis; Fiscal Year: 2011
    ..Interestingly, Brd2 ordinarily binds to PPAR-gamma and opposes its transcriptional activity, thus, Brd2 deficiency resembles thiazolidinedione action...
  7. Nuclear receptor mechanisms controlling macrophage function in health and disease
    Ajay Chawla; Fiscal Year: 2013
    ..Our preliminary data indicate the nuclear receptors PPAR delta and gamma play a key role in orchestrating macrophage transcriptional programs necessary for debris clearance ..
  8. Unique Roles of p160 Coactivators during Human Adipogenesis
    Sean Hartig; Fiscal Year: 2010
    ..Biochemical studies have linked the pi 60s to peroxisome proliferator-activated receptor-gamma (PPAR), the master regulator of adipogenesis...
  9. Nuclear Receptor Interactions on DNA
    Fraydoon Rastinejad; Fiscal Year: 2010
    ..the detailed structural and dynamic properties of the heterodimeric complex involving full-length RXR-alpha/PPAR-gamma proteins in complex with their ligands and assembled on their DNA target site...
  10. PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR EXPRESSION
    NICOLAS GUZMAN; Fiscal Year: 2001
    ..b>PPAR-gamma has been found to be the target of action of thiazolidinediones, a newly developed group of insulin-..
  11. Vsevolod Y Polotsky; Fiscal Year: 2014
    ..binding protein 1c (SREBP-1c), liver X receptors (LXRs) and peroxisome proliferator-activated receptor gamma (PPAR[unreadable]), (2) activation of the sympathetic nervous system (SNS) resulting in increased hepatic glucose output ..
  12. SAGAR PRADEEP BAPAT; Fiscal Year: 2014
    ..one of the genes specifically upregulated in fTregs is peroxisome proliferator-activated receptor gamma (PPAR!), a key regulator of adipogenesis and organismal metabolism...
  13. Sean Hartig; Fiscal Year: 2015
    ..fat metabolism and adipokine expression, are tightly regulated by peroxisome proliferator activated receptor gamma (PPAR?)...
  14. Yihong Wan; Fiscal Year: 2015
    ..Therefore, this investigation will significantly impact the broader scientific, clinical, and patient community. ..
  15. Virtual Screening Development to Complement Experimental Screening for PPAR Modul
    Stephanie N Lewis; Fiscal Year: 2012
    ..Thiazolidinediones (TZDs) work by targeting peroxisome proliferator-activated receptor-gamma (PPAR(), which is a protein known to play a key role in regulation of inflammation and metabolic processes, cancers, and ..
  16. ALEXANDER BANKS; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): PPAR-gamma is the target of highly effective but controversial diabetes medications, the thiazolidinediones...
  17. Yuqing Eugene Chen; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Emerging data suggest that peroxisome proliferator-activated receptor- ? (PPAR-?) is a critical determinant that may provide functional links between diabetes and CVD...
  18. Mechanistic studies of a PPAR-g mutation that causes lipodystrophy &diabetes
    OLGA IGOR ASTAPOVA; Fiscal Year: 2013
    ..PPARg is a ligand-activated nuclear receptor with a well-characterized structure that binds PPAR response elements and regulates transcription of target genes by recruiting coactivators and/or corepressors...
  19. Pharmacogenomics of Thiazolidinedione Response
    Soren Snitker; Fiscal Year: 2012
    ..As an extension of our ongoing Pharmacogenomics of PPAR-gamma project, the Specific Aims of the proposed research are threefold...
  20. Anti-angiogenic Barriers to Tumor Development
    Susan E Crawford; Fiscal Year: 2010
    ..Moreover, a significant decrease in PEDF mRNA was evident when PPAR gamma was over-expressed in rodent livers and PEDF interacted with nuclear receptors suggesting that PEDF may be a ..
  21. Ajay Chawla; Fiscal Year: 2014
    ..dependent on the transcriptional activity of Peroxisome Proliferator Activated Receptors gamma and delta (PPAR gamma and delta), providing a mechanistic basis for the protective functions of these receptors in obesity-induced ..
  22. PPAR Mediated Gene Expression in HIV Patients
    Marie Gelato; Fiscal Year: 2007
    ..Patients with HIV-LD have decreased expression of both PPAR gamma and PPAR alpha -regulated genes...
  23. Mitochondrial Protection Within Chronically Ischemic Myocardium
    Edward O McFalls; Fiscal Year: 2010
    ..protection in mouse hearts under basal conditions and following peroxisome proliferator activated receptor (PPAR) gamma stimulation with chronic dietary administration of pioglitazone...
  24. Effects of fish oil on inflammation and metabolic syndrome
    Philip A Kern; Fiscal Year: 2012
    ..Drugs such as thiazolidinediones (TZDs) improve insulin sensitivity via activation of PPAR-gamma, and there is much evidence that PPARγagonists also have anti-inflammatory properties...
  25. PPAR gamma in pediatric sepsis and the inflammatory response in obesity
    JENNIFER MELISSA KAPLAN; Fiscal Year: 2013
    ..The proposed research is significant because it can lead to novel therapies for patients with sepsis, including the potential use of FDA-approved PPARg ligands, thiazolidinediones, which can augment the PPARg pathway. ..
  26. Cong Yan; Fiscal Year: 2015
    ..To identify the molecular mechanism that controls these events, peroxisome proliferator-activated receptor gamma (PPAR?) appears to be a strong candidate...
  27. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2005
    ..Activators of the nuclear receptor PPAR gamma inhibit macrophage and mesangial cell activation...
  28. Diet-Induced Insulin Resistance and Myocardial Ischemia in Pigs
    Gregory G Schwartz; Fiscal Year: 2013
    ..Therefore, an additional goal is to determine whether chronic treatment with a PPAR alpha or gamma agonist modifies myocardial metabolic and contractile abnormalities in insulin resistant pigs...
  29. Role of PPAR-gamma Isoforms in Regulation of Macrophage apoE & LPL Expression
    Jheem Medh; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Four (4) new PPAR-gamma (g) transcripts have been identified, bringing the total PPAR-g transcript isoforms to 7...
  30. CNS PPAR gamma and energy homeostasis
    HEIDI E KOCALIS; Fiscal Year: 2011
    ..Peroxisome proliferator activated receptors (PPAR) are nuclear receptors that are the target of drugs used clinically to treat diabetes and dyslipidemia...
  31. BENJAMIN DOUGLAS KORMAN; Fiscal Year: 2014
    ..In this proposal, I plan to investigate the role of adipose PPAR-gamma on the process of fibrosis and specifically in animal models of SSc...
  32. SETH BERNAT FURGESON; Fiscal Year: 2015
    ..PROJECT SUMMARY The goal of this project is to define the role of peroxisome proliferator-activated receptor (PPAR)3 activation in neointima formation...
  33. Effects of High Fat Diet and Environmental Obesogen Co-Exposure on Osteoporosis
    Jennifer J Schlezinger; Fiscal Year: 2013
    ..phthalates, are being recognized for their ability to activate peroxisome proliferator activated receptor gamma (PPAR?), the master regulator of adipocyte differentiation...
  34. John A Katzenellenbogen; Fiscal Year: 2016
    ..2) Evaluate Fluorine-18 labeled ligands for the Peroxisome Proliferator-Activated Receptor gamma (PPAR?) as PET imaging agents of predictive value for prostate cancer recurrence...
  35. MOLECULAR ANALYSIS OF TRANSCRIPTIONAL REPRESSION BY TGIF
    David Wotton; Fiscal Year: 2010
    ..whether TGIF and Tiull preferentially target RXR-PPARgamma complexes via a specific interaction of Tiull with PPAR gamma...
  36. Zivar Yousefipour; Fiscal Year: 2016
    ..Peroxisome proliferator activated receptor gamma (PPAR?), a nuclear transcription factor, regulates inflammatory response via modulating the transcription of inflammatory ..
  37. Dysregulated Pathways in Pulmonary Fibrosis
    Keith C Olsen; Fiscal Year: 2012
    ..TG2 was shown to control the function of the transcription factor peroxisome proliferator activated receptor gamma (PPAR?)...
  38. Microparticles as Messengers of Communication Between Blood and Vascular Cells
    Richard P Phipps; Fiscal Year: 2010
    ..that platelets abundantly express the transcription factor peroxisome proliferator activated receptor-gamma (PPAR?) and that PPAR? ligands dampen platelet activation...
  39. DAVID EMERSON GREEN; Fiscal Year: 2016
    ..of the ligand-activated nuclear hormone transcription factor, peroxisome proliferator-activated receptor gamma (PPAR), provides a new potential therapeutic target in PH management...
  40. Farrah Kheradmand; Fiscal Year: 2016
    ..the aryl hydrocarbon receptor (AhR), osteopontin (SPP1), and peroxisome proliferator- activated receptor gamma (PPAR-?), an anti-inflammatory transcription factor...
  41. Linking partial and non-agonist induced dynamics to PPAR gamma functions
    TRAVIS SHANE HUGHES; Fiscal Year: 2013
    ..drugs, (the full agonists rosiglitazone and pioglitazone), bind to peroxisome proliferators-activated receptor PPAR, a transcription factor) and improve maintenance of normal blood sugar levels, which helps prevent the long-term ..
  42. Echium Oil Modulates Macrophage Inflammation by Promoting Alternative Activation
    AMANDA WIBLEY; Fiscal Year: 2010
    ..The nuclear hormone receptor PPAR gamma acts as a lipid-sensor and likely directs this modulation of macrophage activation phenotypes by omega-3 ..
  43. Pathogenic Mechanisms of Fatty Liver Disease
    Mohammad S Siddiqui; Fiscal Year: 2011
    ..lnsig-2 in averting hepatic steatosis in mice fed a HFHC, I will upregulate insig expression in vivo by activating PPAR-gamma pathway which has been shown to increase insig expression...
  44. Preclinical neuroprotective trials of a PPAR-gamma agonist in HD mouse models
    Wenzhen Duan; Fiscal Year: 2012
    ..b>PPAR? activation prevents neuronal degeneration with a concomitant increase in mitochondrial viability...
  45. miRNAs and PPAR-gamma-induced neuroprotection
    Raghu Vemuganti; Fiscal Year: 2013
    ..an in silico observation that the promoters of certain miRNAs contain binding sites for the transcription factor PPAR? known as PPREs...
  46. Frank M Faraci; Fiscal Year: 2016
    ..Our pilot data suggest the transcription factor peroxisome proliferator-activated receptor- (PPAR) has a major influence on the cerebral circulation with links to the RAS...
  47. Audrey S Dickey; Fiscal Year: 2014
    ..several nuclear receptor transcription factors including the three Peroxisome Proliferator-Activated Receptor (PPAR) isoforms, [unreadable], ?, and [unreadable]...
  48. Role of Early B Cell Factor-1 (EBF-1) in Adipocyte Biology
    Michael J Griffin; Fiscal Year: 2010
    ..from mice with a targeted deletion of SCD-1 are smaller and have increased levels of the transcription factor PPAR-gamma, the master regulator of adipogenesis...
  49. Omer Yilmaz; Fiscal Year: 2014
    ..induction of niche Bst-1 by CR and rapamycin boosts ISC function in old mice (Aim 1);that the transcription factor PPAR-gamma mediates this response in Paneth cells (Aim 2);and that cADPR-activated signaling mediates this response in ..
  50. Deborah E Sullivan; Fiscal Year: 2014
    ..Aim 2 will define the molecular crosstalk between peroxisome proliferator-activated receptor gamma (PPAR?) and [unreadable]-catenin pathways during CTB differentiation...
  51. PPAR-gamma as a therapeutic target after TBI
    Raghu Vemuganti; Fiscal Year: 2010
    ..Statins increase PPAR expression which is thought to mediate some of the pleiotropic beneficial effects of statins after an injury...
  52. FABPs Mediate Activation of PPAR Alpha Receptors by N-Acylethanolamines
    Martin Kaczocha; Fiscal Year: 2012
    ..The overall outcome of this study will greatly enhance our understanding of NAE signaling and will ascribe novel functions to FABPs in endocannabinoid biology. ..
  53. Nitrated fatty acids/PPARgamma in the control of renal and vascular functions
    Tianxin Yang; Fiscal Year: 2012
    The proxisome proliferator-activated receptor subtype (PPAR) is a multi-functional ligand-activated transcription factor...
  54. Samantha M Yeligar; Fiscal Year: 2014
    ..alcohol-induced derangements can be reversed by treatment with peroxisome proliferator-activated receptor gamma (PPAR?) ligands, such as pioglitazone and rosiglitazone...
  55. NR4A Orphan Receptors And Insulin Resistance
    W Timothy Garvey; Fiscal Year: 2012
    ..Thiazolidinedione drugs (TZDs) act through agonism of nuclear transcription factors (i.e., PPAR[unreadable]) to enhance insulin sensitivity;however, TZD therapy is associated with adverse effects, including ..
  56. Yoon Kwang Lee; Fiscal Year: 2016
    ..fatty liver development in SHP-/- mice results in part from elevated-fatty acid oxidation due to derepression of PPAR? transcriptional activity, but also to lower expression of PPAR?2, a major lipogenic transcription factor...
  57. Rev-ERBa Regulates Mitochondrial Biogenesis, Adiposity, and Insulin Action
    Thomas H Reynolds; Fiscal Year: 2010
    ..Rev-ERBa represses the expression of peroxisome proliferator-activated receptor-gamma (PPAR?) coactivator 1 alpha (PGC1a), a master regulator of mitochondrial biogenesis...
  58. Establishment of Adiponectin as a PPARgamma Cofactor
    KATHRYN ELLEN DAVIS; Fiscal Year: 2010
    ..Preliminary studies show that overexpression of non-secreted adiponectin enhances glucose tolerance and increases PPAR gamma target gene expression in vivo, similar to the effect of TZD treatment...
  59. Nobuyo Maeda; Fiscal Year: 2016
    ..that the human variants of apoE interact with variants of peroxisome proliferator-activated receptor gamma (PPAR?) in determining the functionality of adipocytes and thence the development of the metabolic syndrome...
  60. Methionine Adenosyltransferase as a Therapeutic Target for Liver Fibrosis
    Komal Ramani; Fiscal Year: 2013
    ..regulated in normal, differentiated HSCs by binding of peroxisome proliferator activated receptor (PPAR-gamma) to the MAT2A promoter...
  61. Mechanisms of PPAR-gamma Enhancement of Cognitive Function in Alzheimer's Disease
    Kelly T Dineley; Fiscal Year: 2013
    ..These findings will have significant impact on our understanding of, and treatment options for, Alzheimer's disease. ..
  62. The Role of PPAR-alpha during Angiotensin II Hypertension
    Dexter L Lee; Fiscal Year: 2012
    ..Peroxisome proliferator-activated receptor (PPAR)-alpha is a nuclear hormone-activated receptor and transcription factor that inhibits, IL-6 production, oxidative ..
  63. Effects of Dietary Fat on Contractile and Mitochondrial Function in Heart Failure
    Margaret P Chandler; Fiscal Year: 2010
    ..Specifically, mRNA and protein expression and activities of enzymes regulating FA metabolic pathways (eg PPAR alpha, PGC-1 alpha, carnitine palmitoyl transferase-l) and activities and modifications of the individual ETC ..
  64. The function(s) and regulation of PPARs in the ovary
    Carolyn Komar; Fiscal Year: 2003
    Peroxisome proliferator-activated receptors (PPARs) are a nuclear receptor superfamily comprised of PPAR alpha, beta, and gamma...
  65. Julie Anne Saugstad; Fiscal Year: 2016
    ..injury in post-ischemic brain is greater in females due to lower levels of peroxisome proliferator activated receptor alpha (PPAR[unreadable]) in T lymphocytes...
  66. Perfluorooctane Sulfonate (PFOS) affects 1gM Production via IL-2
    Margie M Peden Adams; Fiscal Year: 2010
    ..Many compounds in this class, like PFOS, are PPAR-alpha agonists...
  67. Albert R La Spada; Fiscal Year: 2016
    ..As a transcription co-activator, PGC-11 positively modulates several nuclear receptors, including the three PPAR's, termed 1, 3, and 4...
  68. PEROXISOME PROLIFERATORS AND THE CELL CYCLE
    JANE ISHMAEL; Fiscal Year: 2002
    ..effects of peroxisome proliferators appear to be mediated by a direct interaction with peroxisome proliferator activated receptor alpha (PPAR-alpha), which is a member of the steroid/thyroid hormone receptor superfamily of ligand-..
  69. Lipolytic Mechanisms of PPAR Activation
    Jorge Plutzky; Fiscal Year: 2007
    ..lipase (LPL), the central enzyme in triglyceride-rich lipoprotein metabolism, as an endogenous mechanism for PPARalpha activation...
  70. DHEA:PPAR-Dependent and Independent Mechanisms of Action
    Russell Prough; Fiscal Year: 2006
    ..enzymes required for the bioactivation and disposition of chemicals through both Peroxisome Proliferator Activated Receptor Alpha dependent and independent pathways...
  71. Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.
    Margie Peden Adams; Fiscal Year: 2007
    ..of T-dependent antibody production by PFOS by assessing TNP-KLH antibody responses in wild type (control) and PPAR alpha null mice (129/SvlmJ &129S4/SvJae- Pparatm1Gonz/J mice; respectively). Mice will be treated with 0, 0...
  72. PPARY ADIPOGENIC ACTION CONTROL BY COVALENT MODIFICATION
    Evan Rosen; Fiscal Year: 2001
    ..Specifically, the nuclear hormone receptor PPAR-gamma (for peroxisome proliferator-activated receptor) has been shown to be a critical determinant in driving ..
  73. The impact of PPAR-gamma and estrogen receptor crosstalk on insulin action
    Andrea Hevener; Fiscal Year: 2007
    ..Similar to the effects of estrogen, PPAR-gamma (g) activation by thiazolidinediones (TZDs) causes insulin sensitization via alterations is transcription of ..
  74. Transcriptional Co-Regulators and Macrophage Gene Expression
    Christopher K Glass; Fiscal Year: 2010
    ..of this grant demonstrated that the glucocorticoid receptor (GR), the peroxisome proliferator-activated receptor y (PPAR?) and liver X receptors (LXRs) repress responses to toll-like receptor activation in a promoter-, and nuclear ..
  75. Vascular PPAR alpha and atherosclerosis
    Jayme Borensztajn; Fiscal Year: 2009
    ..The nuclear receptor co-activator PBP (PPAR- Binding Protein) is essential for PPARa - regulated gene expression and its absence in hepatocytes causes an ..
  76. MOLECULAR BASIS OF HIV LIPODYSTROPHY: ROLE OF VPR
    Ashok Balasubramanyam; Fiscal Year: 2003
    ..viral protein, Vpr, potentiates ligand-mediated activation of the glucocorticoid receptor (GR), and antagonized PPAR-gamma mediated gene transcription...