PPARD

Summary

Gene Symbol: PPARD
Description: peroxisome proliferator activated receptor delta
Alias: FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB, peroxisome proliferator-activated receptor delta, PPAR-beta, PPAR-delta, nuclear hormone receptor 1, nuclear receptor subfamily 1 group C member 2, peroxisome proliferator-activated nuclear receptor beta/delta variant 2, peroxisome proliferator-activated receptor beta
Species: human

Top Publications

  1. doi Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice
    Xiaomei Qin
    Institute of Cardiovascular Science and Key Laboratory of Cardiovascular Science of Ministry of Education, Peking University Health Science Center, Beijing, China
    Hepatology 48:432-41. 2008
  2. doi PPARdelta is a type 1 IFN target gene and inhibits apoptosis in T cells
    Nadya al Yacoub
    Department of Biology, Free University of Berlin, Berlin, Germany
    J Invest Dermatol 128:1940-9. 2008
  3. ncbi Assignment of the human nuclear hormone receptor, NUC1 (PPARD), to chromosome 6p21.1-p21.2
    T Yoshikawa
    Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Genomics 35:637-8. 1996
  4. pmc The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells
    Imad Shureiqi
    Departments of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9968-73. 2003
  5. ncbi The human peroxisome proliferator-activated receptor delta gene is a primary target of 1alpha,25-dihydroxyvitamin D3 and its nuclear receptor
    Thomas W Dunlop
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Mol Biol 349:248-60. 2005
  6. pmc Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes
    Andrew D Burdick
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Huck Institute of Life Sciences, The Pennsylvania State University, University Park 16802, United States
    Cell Signal 19:1163-71. 2007
  7. pmc PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function
    Sandra Kleiner
    Cardiovascular and Metabolism Disease Area, Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 284:18624-33. 2009
  8. ncbi Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
    Laura Andrulionyte
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes 55:2148-52. 2006
  9. ncbi Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
    H E Xu
    Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    Mol Cell 3:397-403. 1999
  10. pmc PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    T C He
    Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cell 99:335-45. 1999

Research Grants

  1. Stratum Corneum Acidification in the Neonate
    Kenneth Feingold; Fiscal Year: 2007
  2. Methionine Adenosyltransferase as a Therapeutic Target for Liver Fibrosis
    Komal Ramani; Fiscal Year: 2013
  3. Virtual Screening Development to Complement Experimental Screening for PPAR Modul
    Stephanie N Lewis; Fiscal Year: 2012
  4. Nuclear Hormone Receptor in Intestinal Biology
    RAYMOND NELSON DUBOIS; Fiscal Year: 2010
  5. Epigenetics of the Retinoic Acid Paradox
    Nicoletta Sacchi; Fiscal Year: 2013
  6. Repressor-PPAR Interactions in Inflammation and Atherosclerosis
    Grant D Barish; Fiscal Year: 2013
  7. Keisuke Ito; Fiscal Year: 2016
  8. Ronald M Evans; Fiscal Year: 2016
  9. Signaling-pathway-based preventative strategies for alcoholic liver disease
    Albert J Fornace; Fiscal Year: 2013
  10. Joseph L Witztum; Fiscal Year: 2016

Detail Information

Publications194 found, 100 shown here

  1. doi Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice
    Xiaomei Qin
    Institute of Cardiovascular Science and Key Laboratory of Cardiovascular Science of Ministry of Education, Peking University Health Science Center, Beijing, China
    Hepatology 48:432-41. 2008
    ..Furthermore, overexpression of PPARdelta by intravenous infection with the PPARdelta adenovirus induced the expression of Insig-1, suppressed SREBP-1 activation, and, consequently, ameliorated hepatic steatosis in obese db/db mice...
  2. doi PPARdelta is a type 1 IFN target gene and inhibits apoptosis in T cells
    Nadya al Yacoub
    Department of Biology, Free University of Berlin, Berlin, Germany
    J Invest Dermatol 128:1940-9. 2008
    ....
  3. ncbi Assignment of the human nuclear hormone receptor, NUC1 (PPARD), to chromosome 6p21.1-p21.2
    T Yoshikawa
    Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Genomics 35:637-8. 1996
  4. pmc The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells
    Imad Shureiqi
    Departments of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9968-73. 2003
    ..Our findings indicate that the down-regulation of PPAR-delta by 15-LOX-1 through 13-S-HODE is an apoptotic signaling pathway that is activated by NSAIDs...
  5. ncbi The human peroxisome proliferator-activated receptor delta gene is a primary target of 1alpha,25-dihydroxyvitamin D3 and its nuclear receptor
    Thomas W Dunlop
    Department of Biochemistry, University of Kuopio, FIN 70211 Kuopio, Finland
    J Mol Biol 349:248-60. 2005
    ....
  6. pmc Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes
    Andrew D Burdick
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Huck Institute of Life Sciences, The Pennsylvania State University, University Park 16802, United States
    Cell Signal 19:1163-71. 2007
    ....
  7. pmc PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function
    Sandra Kleiner
    Cardiovascular and Metabolism Disease Area, Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 284:18624-33. 2009
    ..However, PPARdelta agonism does not induce mitochondrial gene expression and function. PGC-1alpha-induced FAO and mitochondrial biogenesis appear to be independent of PPARdelta...
  8. ncbi Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial
    Laura Andrulionyte
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes 55:2148-52. 2006
    ..We screened six single nucleotide polymorphisms (SNPs) of the PPAR-delta gene (PPARD) for an association with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in 769 subjects ..
  9. ncbi Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
    H E Xu
    Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    Mol Cell 3:397-403. 1999
    ..We report the crystal structure of the PPAR delta ligand-binding domain (LBD) bound to either the FA eicosapentaenoic acid (EPA) or the synthetic fibrate GW2433...
  10. pmc PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    T C He
    Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cell 99:335-45. 1999
    b>PPARB was identified as a target of APC through the analysis of global gene expression profiles in human colorectal cancer (CRC) cells. PPARdelta expression was elevated in CRCs and repressed by APC in CRC cells...
  11. ncbi Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity
    Hyoung Doo Shin
    Department of Genetic Epidemiology, SNP Genetics, Seoul, Korea
    Diabetes 53:847-51. 2004
    ..The genetic information about PPAR-delta from this study would be useful for further genetic study of obesity, diabetes, and other metabolic diseases...
  12. pmc Association of the T+294C polymorphism in PPAR delta with low HDL cholesterol and coronary heart disease risk in women
    Jens Aberle
    Zentrum fur Innere Medizin, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Int J Med Sci 3:108-11. 2006
    ....
  13. ncbi Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids
    A Schmidt
    Department of Bone Biology and Osteoporosis Research, Merck Research Laboratories, West Point, Pennsylvania 19486
    Mol Endocrinol 6:1634-41. 1992
    ..Similar stimulation was observed with arachidonic and oleic acid (100-250 microM)...
  14. ncbi The human peroxisome proliferator-activated receptor (PPAR) subtype NUC1 represses the activation of hPPAR alpha and thyroid hormone receptors
    L Jow
    Department of Molecular Biology, Ligand Pharmaceuticals Inc, San Diego, California 92121
    J Biol Chem 270:3836-40. 1995
    ..Our data further suggests convergence of thyroid hormone- and peroxisome-mediated fatty acid metabolism pathways. Overcoming hNUC1 repression could be a means of increasing the activity of these receptors...
  15. pmc Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
    S A Kliewer
    Department of Molecular Endocrinology, Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 94:4318-23. 1997
    ..These data provide evidence that PPARs serve as physiological sensors of lipid levels and suggest a molecular mechanism whereby dietary fatty acids can modulate lipid homeostasis...
  16. ncbi Roles of PPARs in health and disease
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, Switzerland
    Nature 405:421-4. 2000
    ..Here we present the latest developments in the PPAR field, with particular emphasis on the physiological function of PPARs during various nutritional states, and the possible role of PPARs in several chronic diseases...
  17. pmc Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)
    J M Peters
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:5119-28. 2000
    ..These results are the first to provide in vivo evidence of significant roles for PPARbeta in development, myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation...
  18. ncbi Alterations of peroxisome proliferator-activated receptor delta activity affect fatty acid-controlled adipose differentiation
    C Bastie
    Institut de Recherche Signalisation, Biologie du Developpement et Cancer, INSERM U470, Centre de Biochimie, Faculte des Sciences, Universite de Nice Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 2, France
    J Biol Chem 275:38768-73. 2000
    ..Furthermore, they suggest that modulation of PPARdelta expression or activity could affect adaptive responses of white adipose tissue to nutritional changes...
  19. pmc Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells
    B H Park
    Johns Hopkins Oncology Center and Howard Hughes Medical Institute, 1650 Orleans Street, Room 590, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 98:2598-603. 2001
    ..These data suggest that suppression of PPARdelta expression contributes to the growth-inhibitory effects of the APC tumor suppressor...
  20. ncbi Prostacyclin-dependent apoptosis mediated by PPAR delta
    T Hatae
    Department of Pharmacology, National Cardiovascular Center Research Institute, Fujishiro dai, Suita, Osaka 565 8565, Japan
    J Biol Chem 276:46260-7. 2001
    ..kidney 293 cells promotes apoptosis by activating endogenous peroxisome proliferator-activated receptor delta (PPAR delta). In contrast, treatment of cells with extracellular prostacyclin or dibutyryl cAMP actually reduced apoptosis...
  21. pmc The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling
    Yanhong Shi
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:2613-8. 2002
    ....
  22. pmc Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation
    Anne M Krogsdam
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense University, Campusvej 55, DK 5230 Odense M, Denmark
    Biochem J 363:157-65. 2002
    ..NCoR interacted strongly with the ligand-binding domain of PPAR delta, whereas interactions with the ligand-binding domains of PPAR gamma and PPAR alpha were significantly weaker...
  23. ncbi Differential regulation of vascular endothelial growth factor expression by peroxisome proliferator-activated receptors in bladder cancer cells
    Sylvie Fauconnet
    Institut d Etudes et de Transfert de Gènes Bâtiment INSERM, 240 route de Dole, Besancon, France
    J Biol Chem 277:23534-43. 2002
    ..They may lead to a new therapeutic approach to human bladder cancer in which excessive angiogenesis is a negative prognostic factor...
  24. ncbi Evidence that peroxisome proliferator-activated receptor delta influences cholesterol metabolism in men
    Josefin Skogsberg
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 23:637-43. 2003
    The objective of this work was to explore the role of peroxisome proliferator-activated receptor delta (PPARD) in lipid metabolism in humans.
  25. ncbi Transcriptional repression of atherogenic inflammation: modulation by PPARdelta
    Chih Hao Lee
    Howard Hughes Medical Institute, Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 302:453-7. 2003
    ..PPARdelta and its ligands may thus serve as therapeutic targets to attenuate inflammation and slow the progression of atherosclerosis...
  26. ncbi Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men
    J Skogsberg
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    J Intern Med 254:597-604. 2003
    b>Peroxisome proliferator activated receptor delta (PPARD) is a transcription factor implicated in the regulation of genes involved in cholesterol metabolism...
  27. ncbi Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth
    Rajnish A Gupta
    Department of Medicine, The Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6838, USA
    Nat Med 10:245-7. 2004
    ..The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth...
  28. ncbi Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 122:971-83. 2004
    ..Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes...
  29. ncbi Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta
    David Kitz Krämer
    Department of Surgical Science, Karolinska Institute, Stockholm, Sweden
    Diabetes 54:1157-63. 2005
    ..Moreover, we provide biological validation of PPARdelta as a potential target for antidiabetic therapy...
  30. ncbi Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators
    Ferdinand Molnár
    Department of Biochemistry, University of Kuopio, Kuopio FIN 70211, Finland
    J Biol Chem 280:26543-56. 2005
    ..This leads to high basal activity of PPARs and provides an additional view on PPAR signaling...
  31. ncbi [PPARdelta + 294T/C gene polymorphism related to plasma lipid, obesity and left ventricular hypertrophy in subjects with metabolic syndrome]
    Zhen Cheng Yan
    Department of Hypertension and Endocrinology, Chongqing Institute of Hypertension, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Zhonghua Xin Xue Guan Bing Za Zhi 33:529-33. 2005
    ..To investigate the relationship between PPARdelta + 294T/C gene polymorphism and lipid profile, obesity and left ventricular hypertrophy (LVH) in patients with metabolic syndrome (MS)...
  32. ncbi The peroxisome proliferator-activated receptor delta +294T/C polymorphism in relation to lipoprotein metabolism in patients with diabetes mellitus type 2 and in non-diabetic controls
    Ioanna Gouni-Berthold
    Department of Internal Medicine II, University of Cologne and Center of Molecular Medicine Cologne CMMC, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Atherosclerosis 183:336-41. 2005
    ..Furthermore, a possible gene-gene interaction between the PPARdelta +294T/C polymorphism and the PPARalpha L162V polymorphism was examined...
  33. ncbi Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake
    Markku Vänttinen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    Diabetes 54:3587-91. 2005
    ..The PPAR-delta gene (PPARD) maps to 6p21.2-p21.1 and has 11 exons and spans 35 kbp...
  34. ncbi Quantitative analysis of PPARdelta mRNA by real-time RT-PCR in 86 rectal cancer tissues
    L Yang
    Department of General Surgery and Division of Digestive Surgery and Organ Microcirculation, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    Eur J Surg Oncol 32:181-5. 2006
    ..The purpose of this study is to clarify the expression change of PPARdelta gene in human colorectal cancer tissues...
  35. pmc PPAR delta: a dagger in the heart of the metabolic syndrome
    Grant D Barish
    Howard Hughes Medical Institute, Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    J Clin Invest 116:590-7. 2006
    ....
  36. ncbi Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V
    J Aberle
    Zentrum fur Innere Medizin, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Int J Obes (Lond) 30:1709-13. 2006
    ....
  37. ncbi Low-intensity exercise increases skeletal muscle protein expression of PPARdelta and UCP3 in type 2 diabetic patients
    Tomas Fritz
    Centre of Family Medicine, Karolinska University Hospital, Karolinska Institutet, 171 11 Stockholm, Sweden
    Diabetes Metab Res Rev 22:492-8. 2006
    ..We tested the hypothesis that changes in expression of key genes in skeletal muscles relate to exercise-induced improvements in type 2 diabetic patients...
  38. ncbi Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor-delta -87T>C polymorphism and dietary fat in French-Canadians
    J Robitaille
    Lipid Research Center, CHUQ CHUL Pavilion, Ste Foy, Quebec, Canada
    Int J Obes (Lond) 31:411-7. 2007
    ..We verified whether genetic variants in this gene are associated with the MS and whether dietary fatty acids interact with the -87T>C polymorphism...
  39. ncbi A novel positive feedback loop between peroxisome proliferator-activated receptor-delta and prostaglandin E2 signaling pathways for human cholangiocarcinoma cell growth
    Lihong Xu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 281:33982-96. 2006
    ..This positive feedback loop plays an important role for cholangiocarcinoma cell growth and may be targeted for chemoprevention and treatment...
  40. ncbi PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's disease
    Julia Holzapfel
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 408:57-61. 2006
    ..three frequent polymorphisms located in exons 4 (rs2016520) and 9 (rs3734254 and rs9794) of the PPARdelta gene (PPARD) for their putative influence on the risk of AD and on plasma levels of cholesterol, 24S-hydroxycholesterol and 27-..
  41. ncbi Peroxisome proliferator-activated receptor (PPAR) delta genetic polymorphism and its association with insulin resistance index and fasting plasma glucose concentrations in Chinese subjects
    C Hu
    Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai, China
    Diabet Med 23:1307-12. 2006
    Previous studies have shown that the peroxisome proliferator-activated receptor delta (PPARD) genetic polymorphism affects cholesterol metabolism in Whites...
  42. pmc Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, 2220 Pierce Avenue, Nashville, TN 37232 2279, USA
    Proc Natl Acad Sci U S A 103:19069-74. 2006
    ....
  43. ncbi Block of nuclear receptor ubiquitination. A mechanism of ligand-dependent control of peroxisome proliferator-activated receptor delta activity
    Davide Genini
    Laboratory of Experimental Oncology, Oncology Institute of Southern Switzerland, CH 6500 Bellinzona, Switzerland
    J Biol Chem 282:11776-85. 2007
    ....
  44. ncbi New therapeutic target for metabolic syndrome: PPARdelta
    Sadao Takahashi
    Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Japan
    Endocr J 54:347-57. 2007
  45. ncbi Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people
    N Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 14, 2820 Gentofte, Copenhagen, Denmark
    Diabetologia 50:1201-8. 2007
    ..Moreover, PPARdelta augments physical endurance and increases oxidative metabolism, thereby averting obesity. Thus, we hypothesised that common variation in the PPARD gene is associated with insulin resistance and metabolic traits.
  46. ncbi Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta
    Tatjana Degenhardt
    Department of Biochemistry, University of Kuopio, FIN 70211, Kuopio, Finland
    J Mol Biol 372:341-55. 2007
    ..In conclusion, PDK2, PDK3 and PDK4 are primary PPARbeta/delta target genes in humans underlining the importance of the receptor in the control of metabolism...
  47. pmc Alternative splicing of human peroxisome proliferator-activated receptor delta (PPAR delta): effects on translation efficiency and trans-activation ability
    Kerstin Lundell
    The Atherosclerosis Research Unit, King Gustaf V Research Institute, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    BMC Mol Biol 8:70. 2007
    Peroxisome proliferator-activated receptor delta (PPAR delta) is a member of the nuclear receptor superfamily...
  48. ncbi [Association of PPARD gene polymorphism with human physical performance]
    I I Akhmetov
    Mol Biol (Mosk) 41:852-7. 2007
    ..To examine the association of a functional +294T/C polymorphism of PPARD gene with human physical performance, we have studied the distribution of PPARD alleles and genotypes in a cohort ..
  49. doi Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study
    Claus Thamer
    Department of Endocrinology, Metabolism, Clinical Chemistry, Nephrology, and Angiology, Medical Clinic, Eberhard Karls University, 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 93:1497-500. 2008
    ..that single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor-delta gene (PPARD), i.e...
  50. pmc PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis
    Grant D Barish
    Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:4271-6. 2008
    ..These results reveal that PPARdelta antagonizes multiple proinflammatory pathways and suggest PPARdelta-selective drugs as candidate therapeutics for atherosclerosis...
  51. doi Impact of peroxisome proliferator-activated receptors gamma and delta on adiposity in toddlers and preschoolers in the GENESIS Study
    Vasiliki Lagou
    Faculty of Biomedical and Life Sciences, Institute of Diet, Exercise and Lifestyle IDEAL, University of Glasgow, Glasgow, UK
    Obesity (Silver Spring) 16:913-8. 2008
    ..proliferator-activated receptor gamma (PPAR gamma) and peroxisome proliferator-activated receptor delta (PPAR delta) are promising candidate genes for obesity...
  52. pmc Peroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer
    Tetyana V Pedchenko
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6838, USA
    Am J Respir Cell Mol Biol 39:689-96. 2008
    ..In conclusion, PPARbeta/delta is strongly expressed in the majority of lung cancers, and its activation induces proliferative and survival response in non-small cell lung cancer...
  53. pmc Association study of Wnt signaling pathway genes in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 65:785-93. 2008
    ..The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder...
  54. pmc Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Whitehead Bioresearch Building, 615 Michael Street, Suite 205 M, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 40:325-31. 2009
    ..This study unveils a novel mechanism by which GW501516 and activation of PPARbeta/delta stimulate human lung carcinoma cell proliferation, and suggests that activation of AMPKalpha may oppose this effect...
  55. pmc Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 58:579-89. 2009
    ..Long-chain fatty acids (LCFAs) contribute to metabolic homeostasis in part via gene regulation. This study's objective was to identify novel LCFA target genes in human skeletal muscle cells (myotubes)...
  56. pmc Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing
    Han Chung Chong
    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    J Cell Biol 184:817-31. 2009
    ..Given the ubiquitous expression of PPARbeta/delta, other epithelial-mesenchymal interactions may also be regulated in a similar manner...
  57. doi Comparison of PPARδ and PPARγ in inhibiting the pro-inflammatory effects of C-reactive protein in endothelial cells
    Yao Jen Liang
    Department and Institute of Life Science, Fu Jen Catholic University, and Department of Medical Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Int J Cardiol 143:361-7. 2010
    ..Recently, PPARδ has revealed benefits for dealing with inflammation. The relationship between CRP-induced inflammation and PPARδ agonist remains unclear...
  58. doi Unlike PPARgamma, PPARalpha or PPARbeta/delta activation does not promote human monocyte differentiation toward alternative macrophages
    Mohamed Amine Bouhlel
    Univ Lille Nord de France, F 59000 Lille, France
    Biochem Biophys Res Commun 386:459-62. 2009
    ..Thus, PPARalpha and PPARbeta/delta do not appear to modulate the alternative differentiation of human macrophages...
  59. pmc Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cells
    Min Chien Tsai
    Division of Medical Engineering Research, National Health Research Institutes, Miaoli 350, Taiwan
    Circ Res 105:471-80. 2009
    ..The role of flow-induced shear stress in the modulation of SMC phenotype has not been well defined...
  60. doi Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta
    Ewa Ehrenborg
    Atherosclerosis Research Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Pharmacol Rev 61:373-93. 2009
    ..In this review we summarize the current status regarding the regulation, and the metabolic effects, of PPARdelta in skeletal muscle...
  61. pmc PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance
    Lata Mukundan
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Nat Med 15:1266-72. 2009
    ..This increases autoantibody production and predisposes global and macrophage-specific Ppard(-/-) mice to autoimmune kidney disease, a phenotype resembling the human disease systemic lupus erythematosus...
  62. doi PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress
    Faisal Ali
    Bywaters Center for Vascular Inflammation, Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Cardiovasc Res 85:701-10. 2010
    ..We investigated the role of PPARdelta and its co-activator, PPARgamma co-activator 1alpha (PGC1alpha), in vasculoprotection against oxidant-induced injury via induction of haem oxygenase-1...
  63. doi Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell-fibronectin adhesion of colon cancer cells
    L Yang
    Division of Oncology, Department of Clinical and Experiment Medicine, Linkoping University, S 581 85 Linkoping, Sweden
    Oncogene 29:516-26. 2010
    ..Interestingly, PPAR-beta seems to have a more important role in poorly metastatic cells than in highly metastatic ones...
  64. doi Association of the CYBA, PPARGC1A, PPARG3, and PPARD gene variants with coronary artery disease and metabolic risk factors of coronary atherosclerosis in a Russian population
    Alexey G Nikitin
    Department of Molecular Diagnostics, National Research Center GosNIIgenetika, 1st Dorozhny Proezd 1, 117545 Moscow, Russia
    Heart Vessels 25:229-36. 2010
    ..In this study, we evaluate whether the PPARGC1A Gly482Ser, PPARG3 (-681)C/G, PPARD +294T/C, and CYBA +242C/T gene variants confer the risk of CAD in a Russian population...
  65. pmc Transcriptional profiling identifies functional interactions of TGF β and PPAR β/δ signaling: synergistic induction of ANGPTL4 transcription
    Kerstin Kaddatz
    Institute of Molecular Biology and Tumor Research, Philipps University, Emil Mannkopff Strasse 2, 35032 Marburg, Germany
    J Biol Chem 285:29469-79. 2010
    ..Although the PPAR-E is not regulated by TGFβ, it interacts with SMAD3, ETS1, RUNX2, and AP-1 in vivo, providing a possible mechanistic explanation for the observed synergism...
  66. doi +294T/C polymorphism in the PPAR-delta gene is associated with risk of coronary artery disease in normolipidemic Tunisians
    I Jguirim-Souissi
    Research Unit Genetic and Biologic Factors of Atherosclerosis, Faculty of Medicine, Monastir, Tunisia
    Genet Mol Res 9:1326-33. 2010
    ....
  67. doi The expression of both peroxisome proliferator-activated receptor delta and cyclooxygenase-2 in tissues is associated with poor prognosis in colorectal cancer patients
    Masahiro Yoshinaga
    Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, Beppu, Oita, 874 0011, Japan
    Dig Dis Sci 56:1194-200. 2011
    ..The role of peroxisome proliferator-activated receptor delta (PPAR δ) in the development and progression of colorectal cancer (CRC) remains controversial...
  68. pmc Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)
    Till Adhikary
    Institute of Molecular Biology and Tumor Research, Philipps University, Marburg, Germany
    PLoS ONE 6:e16344. 2011
    ..These observations have important implications for understanding the regulatory PPAR network and PPARβ/δ ligand-based drugs...
  69. doi Biological function and prognostic significance of peroxisome proliferator-activated receptor δ in rectal cancer
    Lie Yang
    Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    Clin Cancer Res 17:3760-70. 2011
    ..To investigate the expression significance of PPAR β/δ in relation to radiotherapy (RT), clinicopathologic, and prognostic variables of rectal cancer patients...
  70. pmc Associations of type 2 diabetes with common variants in PPARD and the modifying effect of vitamin D among middle-aged and elderly Chinese
    Ling Lu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e34895. 2012
    Previous studies have identified that variants in peroxisome proliferator-activated receptor PPAR-δ (PPARD), a target gene of vitamin D, were significantly associated with fasting glucose and insulin sensitivity in European populations...
  71. ncbi Characterization of the human peroxisome proliferator activated receptor delta gene and its expression
    J Skogsberg
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Int J Mol Med 6:73-81. 2000
    ..Three different PPARs; alpha (PPARA), gamma (PPARG) and delta (PPARD) have been characterized and they are distinguished from each other by tissue distribution and cell activation...
  72. ncbi Peroxisome proliferator-activated receptor-delta polymorphisms are associated with physical performance and plasma lipids: the HERITAGE Family Study
    Arto J Hautala
    Pennington Biomedical Research Center, Human Genomics Laboratory, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Physiol Heart Circ Physiol 292:H2498-505. 2007
    ..DNA sequence variation in the PPARdelta locus is a potential modifier of changes in cardiorespiratory fitness and plasma HDL-C in healthy individuals in response to regular exercise...
  73. ncbi Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
    Norbert Stefan
    Department of Internal Medicine, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 92:1827-33. 2007
    ..Peroxisome proliferator-activated receptor (PPAR)-delta (gene PPARD) and PPARgamma coactivator 1alpha (gene PPARGC1A) are determinants of mitochondrial function in animals and in ..
  74. ncbi Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men
    Ulf Riserus
    Churchill Hospital, Oxford OX3 7LJ, UK
    Diabetes 57:332-9. 2008
    ..We hypothesize a similar mechanism operates in humans...
  75. doi Peroxisome proliferator-activated receptor {delta} regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-{beta}1/Smad3
    Hyo Jung Kim
    Department of Pharmacology, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Chilam Dong, Jinju, Korea
    Circ Res 105:16-24. 2009
    ..Specific ligands of PPARdelta may aid in the therapeutic intervention of atherosclerosis by improving plaque stability and patient prognosis...
  76. pmc Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons
    Alexander Tenenbaum
    Cardiac Rehabilitation Institute, Sheba Medical Center, 52621 Tel Hashomer, Israel
    Cardiovasc Diabetol 4:14. 2005
    ..However, treatment of obese animals by specific PPAR delta agonists results in normalization of metabolic parameters and reduction of adiposity...
  77. doi Preterm and infection-driven preterm labor: the role of peroxisome proliferator-activated receptors and retinoid X receptor
    Sarah J Holdsworth-Carson
    Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Victoria, Australia
    Reproduction 137:1007-15. 2009
    ..Compared with term, preterm parturition was associated with an increased expression of PPAR delta (PPARD; mRNA and protein), PPAR gamma (PPARG; protein) and RXRA (protein) in the placenta and PPARD (mRNA and ..
  78. doi Ligand-dependent and -independent regulation of PPAR gamma and orphan nuclear receptors
    H Eric Xu
    Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue, Northeast, Grand Rapids, MI 49503, USA
    Sci Signal 1:pe52. 2008
    ..is a distinguishing feature of PPAR gamma and two related receptors, PPAR alpha and PPAR beta (also known as PPAR delta), which allows these receptors to interact with diverse chemical ligands including various fatty acids, fibrates,..
  79. pmc Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways
    Feijun Luo
    Department of Pathology, Addenbrooke s Hospital, University of Cambridge, UK
    Int J Exp Pathol 90:558-74. 2009
    ..although other Wnt signalling pathway target genes such as Peroxisome proliferator-activated receptor delta (PPARd), matrix metalloproteinase 7 (MMP7), protein phosphatase 1 alpha (PP1A) and c-myc remained unchanged...
  80. ncbi Rat PPAR delta contains a CGG triplet repeat and is prominently expressed in the thalamic nuclei
    G Xing
    Unit on Gene Mapping and Expression, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 217:1015-25. 1995
    ..sequence encoded by the cDNA clone showed a strong homology to the human NUCI and the mouse peroxisome proliferator activated receptor delta (PPAR delta). We therefore refer to this new clone as rat PPAR delta (rPPAR delta)...
  81. ncbi Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes
    A Ibabe
    Biologia Zelularra eta Histologia Laborategia, Zoologia eta Animali Biologia Zelularra Saila, Zientzia eta Teknologia Fakultatea, Euskal Herriko Unibertsitatea Universidad del País Vasco, 644 PK, Bilbao E 48080, Basque Country, Spain
    Toxicol In Vitro 19:725-35. 2005
    ..Further studies are needed to identify how the expression of different PPAR subtypes is regulated and to elucidate the implication of PPAR subtypes in zebrafish cell functions...
  82. pmc Haplotypes of the porcine peroxisome proliferator-activated receptor delta gene are associated with backfat thickness
    Karina Meidtner
    Chair of Animal Breeding, Technical University of Munich, Hochfeldweg 1, 85354 Freising Weihenstephan, Germany
    BMC Genet 10:76. 2009
    ..It is a key regulator of lipid metabolism. The peroxisome proliferator-activated receptor delta gene (PPARD) has been assigned to a region on porcine chromosome 7, which harbours a quantitative trait locus for backfat...
  83. doi Effect of polymorphisms in four candidate genes for fertility on litter size in a German pig line
    A Spötter
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Germany
    Reprod Domest Anim 45:579-84. 2010
    ..factor receptor (KDR), erbb2 interacting protein (ERBB2IP) and peroxisome proliferator-activated receptor delta (PPARD)...
  84. pmc Genome scan for loci regulating HDL cholesterol levels in Finnish extended pedigrees with early coronary heart disease
    Tiia Kangas-Kontio
    Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland
    Eur J Hum Genet 18:604-13. 2010
    ..6, we analyzed two functional and positional candidate genes (peroxisome proliferator-activated receptor-delta (PPARD), and retinoid X receptor beta, (RXRB)), but found no significant evidence of association...
  85. ncbi Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis
    Fred S Harman
    Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Med 10:481-3. 2004
    ..We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice...
  86. doi Early postnatal oestradiol exposure causes insulin resistance and signs of inflammation in circulation and skeletal muscle
    Camilla Alexanderson
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Endocrinol 201:49-58. 2009
    ..Glut 4), carnitine-palmitoyl transferase 1b (Cpt1b), peroxisome proliferator-activated receptor delta (Ppard) and uncoupling protein 3 (Ucp3), which are connected to glucose uptake, lipid oxidation, and energy uncoupling, ..
  87. ncbi Regulation of the peroxisomal beta-oxidation-dependent pathway by peroxisome proliferator-activated receptor alpha and kinases
    N Latruffe
    LBMC, University of Burgundy, 21000 Dijon, France
    Biochem Pharmacol 60:1027-32. 2000
    ..b>PPAR beta/delta, which is not very well known yet, appears to be more specifically activated by fatty acids...
  88. ncbi Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes
    P S Jones
    Department of Life Science, University of Nottingham, England
    Eur J Biochem 233:219-26. 1995
    ..PPAR) genes were localised to chromosome 15 (PPAR alpha), chromosome 17 (PPAR beta) and chromosome 6 (PPAR gamma)...
  89. ncbi 85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Gastrointest Liver Physiol 282:G586-97. 2002
    ..The cPLA(2) thus may represent a potential therapeutic target for the control of PPAR-related liver and metabolic disorders such as obesity, lipid metabolic disorders, diabetes mellitus, and atherosclerosis...
  90. ncbi Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action
    M Loviscach
    VA San Diego Healthcare System, California 92161, USA
    Diabetologia 43:304-11. 2000
    ....
  91. pmc Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886
    J P Kehrer
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas, Austin, TX 78712, USA
    Biochem J 356:899-906. 2001
    ..Only minimal inhibitory effects were seen on PPAR beta and PPAR gamma...
  92. doi Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis
    Delphine Staumont-Sallé
    INSERM U547, Lille, France
    J Allergy Clin Immunol 121:962-8.e6. 2008
    ..In skin both PPAR-alpha and PPAR-beta/delta regulate keratinocyte proliferation/differentiation and contribute to wound healing. The 3 PPAR isoforms are expressed by several cell types recruited into the dermis during inflammation...
  93. doi Peroxisome proliferator-activated receptors, estrogenic responses and biotransformation system in the liver of salmon exposed to tributyltin and second messenger activator
    Nela Pavlikova
    Department of Biology, Norwegian University of Science and Technology NTNU, Høgskoleringen 5, 7491 Trondheim, Norway
    Aquat Toxicol 99:176-85. 2010
    ..Our data showed a consistent increase in PPAR alpha, PPAR beta and PPAR gamma mRNA and protein expression after TBT exposure that were inversely correlated with ACOX1 mRNA ..
  94. pmc Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination
    Antoinette Defaux
    Department of Physiology, University of Lausanne, CH 1005 Lausanne, Switzerland
    J Neuroinflammation 6:15. 2009
    ..GW 501516, a specific PPAR-beta agonist, was examined for its capacity to protect from antibody-mediated demyelination and to prevent inflammatory responses induced by IFN-gamma and LPS...
  95. pmc Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs
    Jennifer E Foreman
    Department of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Mol Carcinog 48:942-52. 2009
    Studies indicate that peroxisome proliferator-activated receptor-beta/delta (PPAR beta/delta) can either attenuate or potentiate colon cancer...
  96. doi Review of the expression of peroxisome proliferator-activated receptors alpha (PPAR alpha), beta (PPAR beta), and gamma (PPAR gamma) in rodent and human development
    Barbara D Abbott
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 27:246-57. 2009
    ..The features of the PPAR nuclear receptor family are introduced and what is known or inferred about their roles in development is discussed relative to insights from genetically modified mice and studies in the adult...
  97. doi Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway
    Rosario Jimenez
    Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain
    J Pharmacol Exp Ther 332:554-61. 2010
    ..In conclusion, the PPAR-beta agonists acutely caused vasodilatation, which was partially dependent on endothelial-derived NO. The eNOS activation is calcium-independent and seems to be related to activation of the PI3K-Akt-eNOS pathway...
  98. ncbi Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells
    Karine Hellemans
    Laboratory of Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels, Laarbeeklaan 103, 1090 Brussel Jette, Belgium
    Gastroenterology 124:184-201. 2003
    ..In a second part of the study, the effect of a PPAR-beta agonist on acute liver injury was evaluated...
  99. doi PPAR-beta facilitating maturation of hepatic-like tissue derived from mouse embryonic stem cells accompanied by mitochondriogenesis and membrane potential retention
    Dan Yan Zhu
    Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou 310058, China
    J Cell Biochem 109:498-508. 2010
    ..The stimulation of PPAR-beta but not -gamma enhanced hepatogenesis, hepatocytes maturation, and mitochondriogenesis. PPAR-beta took an important role in cellular energy metabolism of hepatogenesis...
  100. doi Effect of nutritional vitamin A deficiency on lipid metabolism in the rat heart: Its relation to PPAR gene expression
    Verónica Analía Vega
    Department of Biochemistry and Biological Sciences, National University of San Luis, and IMIBIO SL, CONICET, Argentina
    Nutrition 25:828-38. 2009
    ....
  101. ncbi The peroxisome proliferator-activated receptors at the cross-road of diet and hormonal signalling
    B Desvergne
    Institut de Biologie Animale, Faculte des Sciences, Universite de Lausanne, Switzerland
    J Steroid Biochem Mol Biol 65:65-74. 1998
    ..The function of the ubiquitously expressed isotype, PPAR beta, remains to be determined...

Research Grants36

  1. Stratum Corneum Acidification in the Neonate
    Kenneth Feingold; Fiscal Year: 2007
    ..develop, and the SC ultimately acidifies, a process that can be accelerated by activation of PPAR alpha, PPAR delta, and LXR...
  2. Methionine Adenosyltransferase as a Therapeutic Target for Liver Fibrosis
    Komal Ramani; Fiscal Year: 2013
    ..My long term plan is to establish myself as an independent Investigator in the field of human liver fibrosis and cirrhosis. ..
  3. Virtual Screening Development to Complement Experimental Screening for PPAR Modul
    Stephanie N Lewis; Fiscal Year: 2012
    ..However, the number of potential natural compounds that could activate PPAR( and/or the other subtypes (PPARa and PPARd) is too large for a compound-by-compound analysis...
  4. Nuclear Hormone Receptor in Intestinal Biology
    RAYMOND NELSON DUBOIS; Fiscal Year: 2010
    ..There are three PPAR isoforms, PPARa, PPARd, and PPAR?, which belong to the nuclear hormone receptor superfamily...
  5. Epigenetics of the Retinoic Acid Paradox
    Nicoletta Sacchi; Fiscal Year: 2013
    ..by non-RAR targets capable of interacting directly with RA, such as the Protein Kinase C alpha (PKCA) and PPAR beta/delta (PPARD) pathways...
  6. Repressor-PPAR Interactions in Inflammation and Atherosclerosis
    Grant D Barish; Fiscal Year: 2013
    ..Importantly, two PPAR isotypes are expressed in macrophages, PPARg and PPARd, and synthetic activators of each of these receptors are anti-inflammatory and anti-atherosclerotic in mouse ..
  7. Keisuke Ito; Fiscal Year: 2016
    ..of inactivation of PPAR-fatty acid oxidation in stem cells;We have previously shown that stem cells exhibit higher Ppard expression and fatty acid oxidation than committed progenitor cells, and have hypothesized that lipid metabolism ..
  8. Ronald M Evans; Fiscal Year: 2016
    ..To do this, in Aim I we will use state-of-the-art protein chemistry techniques to define the dynamic properties of PPARd epi-genomic complexes assembled in the presence of two selective modulators GW1516 and Syndag CBL-28...
  9. Signaling-pathway-based preventative strategies for alcoholic liver disease
    Albert J Fornace; Fiscal Year: 2013
    ..Specific aim 1 will use the Ppara-null and Pparb/d-null mouse models to distinguish between the suitability of targeting these receptors to inhibit early and/or ..
  10. Joseph L Witztum; Fiscal Year: 2016
    ..There is extensive evidence that PPARg and PPARd ligands inhibit inflammatory processes, including TLR-dependent mechanisms, and we will use a combination of ..
  11. Jeffrey M Peters; Fiscal Year: 2016
    ..Moreover, results could provide framework for screening of effective compounds that can activate either PPRE-driven and/or epigenetic pathways for selective modulation of PPAR[unreadable]/[unreadable] for chemoprevention. ..
  12. Genetic analysis of a spontaneous mutation in a rat with a novel hind limb defect
    Debasish Sinha; Fiscal Year: 2010
    ..spontaneously from a mating of two Sprague Dawley rats in a colony that we maintain to study another mutation, Nuc1. Nuc1 is an eye-specific phenotype with developmental abnormalities that we have been investigating for several ..
  13. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 2001
    ..The hypothesis will also be tested that PPARd is constitutively expressed and expression of other PPARS is developmentally regulated...
  14. PPARgamma, Toll-like receptors, and atherosclerosis
    Christopher Glass; Fiscal Year: 2007
    ..There is now extensive evidence that PPARa, PPAR?, and PPARd ligands inhibit inflammatory processes in macrophages and other cells within the artery wall that are linked to ..
  15. Mark I, Model 68A Cesium 137 Research Irradiator
    Robert Paulson; Fiscal Year: 2003
    ..and wound healing; erythropoiesis and erythropoietin receptor signaling; and molecular mechanisms of proto-oncogene and viral oncogene action, including studies of Friend virus gp55, Sf-Stk, PPARb and Patched, and Piml.
  16. PPARs in Atherosclerosis and Immunity
    GRANT BARISH; Fiscal Year: 2006
    ..Additionally, PPARg and PPARd are expressed in macrophages and appear to have roles in atherosclerosis...
  17. MODULATION OF CIITA BY CANNABINOIDS IN HUMAN MICROGLIA
    Debasish Sinha; Fiscal Year: 2004
    ..Microglia form the first line of defense during infection in the CNS and are involved in various immune diseases including AIDS. ..
  18. A CRYSTALLIN MUTATION WITH ABNORMAL ASTROCYTES AND RETINAL VESSELS
    Debasish Sinha; Fiscal Year: 2010
    ..have discovered a spontaneous mutation in the Sprague Dawley rat with an unusual eye phenotype that we have named Nuc1. The mutation behaves as a single semi-dominant locus with a viable homozygote and an intermediate phenotype in the ..
  19. Role of the PPARb in epithelial cell proliferation
    Jeffrey Peters; Fiscal Year: 2004
    ..contribute to diseases including hyperlipidemias, atherosclerosis, obesity, diabetes and cancer, the function of PPARb has remained a mystery...
  20. Modulation of AhR-dependent signaling by PPARb/d
    Jeffrey M Peters; Fiscal Year: 2010
    ..abstract_text> ..
  21. Role of PPARbeta in colon carcinogenesis
    Jeffrey Peters; Fiscal Year: 2007
    ..abstract_text> ..
  22. Leukemia inhibitor factor in skeletal muscle regrowth
    Espen Spangenburg; Fiscal Year: 2003
    ..Identification of a cytokine and a signaling mechanism that may regulate muscle growth could lead to other counter-measures to ultimately prevent muscle wasting. ..
  23. Molecular Targeting of 15-Lipoxygenase-1 in Colon Cancer
    Imad Shureiqi; Fiscal Year: 2007
    ..the feasibility of tumor selective targeting of 15-LOX-1 to inhibit tumorigenesis will pave the way for future preclinical and clinical development of therapeutic strategies based on molecularly targeting 15-LOX-1 ..
  24. Genetic Aspects of Vestibular Dysfunction
    Stephen Roth; Fiscal Year: 2004
    ..The proposed project will generate important pilot data related to the genetics of vestibular dysfunction, thus fitting within the R21 grant mechanism. ..
  25. 7th Intl Symposium-Neurobiology/Neuroendocrinology/Aging
    Andrzej Bartke; Fiscal Year: 2004
    ..We are also seeking support for the presenters of the Special Lecture and the Keynote Lecture who will be traveling to Bregenz from the United States. ..
  26. LINOLEIC ACID METABOLISM AND COLON CARCINOGENESIS
    Imad Shureiqi; Fiscal Year: 2005
    ..This work will set the stage for future animals and clinical studies of LA alternative pathway modulation as means of colon cancer chemoprevention. ..
  27. Aging:Mechanisms & Prevention:34th Annual Meeting of AGE
    Andrzej Bartke; Fiscal Year: 2005
    ..Financial assistance will be provided to those in training to encourage their participation in the meeting. ..
  28. Genetic Architecture of Aging Skeletal Muscle
    Stephen Roth; Fiscal Year: 2005
    ..abstract_text> ..
  29. Structural Biology of Class B G-Protein Coupled Receptors
    H Eric Xu; Fiscal Year: 2010
    ..PHS 398/2590 (Rev. 11/07) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): Xu, H. Eric ..
  30. Structural and functional studies of the nuclear receptor PPARgamma
    H Eric Xu; Fiscal Year: 2010
    ....
  31. Structure and Functions of Steroid Hormone Receptors
    H Eric Xu; Fiscal Year: 2010
    ..abstract_text> ..
  32. Eighth & Ninth International Symposia on Neurobiology & Neuroendocrinology Aging
    Andrzej Bartke; Fiscal Year: 2007
    ..We are also seeking partial support for the expenses of invited speakers from the United States. [unreadable] [unreadable] [unreadable]..
  33. Methods for high-dimensional data in HIV research
    Andrea Foulkes; Fiscal Year: 2009
    ....
  34. Regulation of skeletal alpha actin expression during mu*
    Espen Spangenburg; Fiscal Year: 2008
    ..The overall goal is to determine the role IGF-I may have in activating transcriptional activity during muscle regrowth. ..
  35. 5-LOX-1 and Clinical Chemoprevention of Colon Tumors
    Imad Shureiqi; Fiscal Year: 2008
    ..If our hypothesis is confirmed, efforts can be directed to develop chemopreventive interventions that specifically target the GATA-6 and 15-LOX-1 signaling pathway. ..
  36. Genetic Epidemiology of Aging Skeletal Muscle
    Stephen Roth; Fiscal Year: 2007
    ..abstract_text> ..