RANTES

Summary

Gene Symbol: RANTES
Description: C-C motif chemokine ligand 5
Alias: D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine 5, T-cell specific protein p288, beta-chemokine RANTES, chemokine (C-C motif) ligand 5, eosinophil chemotactic cytokine, regulated upon activation, normally T-expressed, and presumably secreted, small inducible cytokine subfamily A (Cys-Cys), member 5
Species: human

Top Publications

  1. ncbi Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
    F Cocchi
    Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA
    Science 270:1811-5. 1995
  2. ncbi The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
    F Cocchi
    Institute of Human Virology, University of Maryland Biotechnology Institute and School of Medicine, Baltimore, Maryland 21201, USA
    Nat Med 2:1244-7. 1996
  3. pmc Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity
    O Meucci
    Department of Pharmacological and Physiological Sciences, University of Chicago, 947 E 58th Street MC 0926, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 95:14500-5. 1998
  4. pmc Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
    Gali Soria
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Israel
    BMC Cancer 11:130. 2011
  5. pmc Involvement of both the V2 and V3 regions of the CCR5-tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to macrophage inflammatory protein 1alpha
    Y Maeda
    Department of Biodefence and Medical Virology, School of Medicine, Kumamoto University, Kumamoto, Japan
    J Virol 74:1787-93. 2000
  6. doi Relationship between CCL5 and transforming growth factor-β1 (TGFβ1) in breast cancer
    M C Hartmann
    Division of Surgery, School of Medicine, National University of Ireland Galway, Ireland
    Eur J Cancer 47:1669-75. 2011
  7. ncbi RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs
    Yusuke Koizumi
    Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    AIDS Res Hum Retroviruses 23:713-9. 2007
  8. pmc Association between regulated upon activation, normal T cells expressed and secreted (RANTES) -28C/G polymorphism and asthma risk--a meta-analysis
    Qiaoqiao Fang
    Department of Respiratory Medicine, Nanjing Children s Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China
    Int J Med Sci 7:55-61. 2010
  9. pmc Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines
    A Trkola
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10021, USA
    J Virol 72:396-404. 1998
  10. doi CCL5/RANTES chemokine gene promoter polymorphisms are not associated with atopic and nonatopic asthma in a Spanish population
    M Muro
    Department of Immunology, University Hospital Virgen Arrixaca, Murcia, Spain
    Int J Immunogenet 35:19-23. 2008

Research Grants

  1. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
  2. CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIV
    Catarina E Hioe; Fiscal Year: 2010
  3. Nicholas W Lukacs; Fiscal Year: 2016
  4. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
  5. TOMASZ K KORDULA; Fiscal Year: 2016
  6. Genital Anaerobes, Inflammation and HIV Risk;Rakai
    LANCE BRADLEY PRICE; Fiscal Year: 2012
  7. Marcus Kaul; Fiscal Year: 2016
  8. Chaim Putterman; Fiscal Year: 2014
  9. In Vivo Brain Dialysis of Neuropeptides and Neuroimmune Signaling Proteins
    Julie A Stenken; Fiscal Year: 2012
  10. Role of Cocaine in Neuro-AIDS by HIV 1B and C Clades
    Madhavan P Nair; Fiscal Year: 2012

Detail Information

Publications256 found, 100 shown here

  1. ncbi Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
    F Cocchi
    Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA
    Science 270:1811-5. 1995
    ..The chemokines RANTES, MIP-1 alpha, and MIP-1 beta were identified as the major HIV-SF produced by CD8+ T cells...
  2. ncbi The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
    F Cocchi
    Institute of Human Virology, University of Maryland Biotechnology Institute and School of Medicine, Baltimore, Maryland 21201, USA
    Nat Med 2:1244-7. 1996
    ..The C-C chemokines RANTES, MIP-1 alpha and MIP-1 beta were recently identified as the major components of the HIV-SF produced by both ..
  3. pmc Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity
    O Meucci
    Department of Pharmacological and Physiological Sciences, University of Chicago, 947 E 58th Street MC 0926, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 95:14500-5. 1998
    ..Fura-2-based Ca imaging showed that numerous chemokines, including SDF-1alpha, RANTES, and fractalkine, affect neuronal Ca signaling, suggesting that hippocampal neurons possess a wide variety of ..
  4. pmc Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
    Gali Soria
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Israel
    BMC Cancer 11:130. 2011
    The inflammatory chemokines CCL2 (MCP-1) & CCL5 (RANTES) and the inflammatory cytokines TNFα & IL-1β were shown to contribute to breast cancer development and metastasis...
  5. pmc Involvement of both the V2 and V3 regions of the CCR5-tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to macrophage inflammatory protein 1alpha
    Y Maeda
    Department of Biodefence and Medical Virology, School of Medicine, Kumamoto University, Kumamoto, Japan
    J Virol 74:1787-93. 2000
    ..The variants were also resistant to other natural ligands for CCR5, namely, MIP-1beta (>4-fold) and RANTES (regulated upon activation, normal T-cell expressed and secreted) (6-fold)...
  6. doi Relationship between CCL5 and transforming growth factor-β1 (TGFβ1) in breast cancer
    M C Hartmann
    Division of Surgery, School of Medicine, National University of Ireland Galway, Ireland
    Eur J Cancer 47:1669-75. 2011
    ..Hormonal control of CCL5, and a potential relationship with TGFβ1, was also investigated...
  7. ncbi RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs
    Yusuke Koizumi
    Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    AIDS Res Hum Retroviruses 23:713-9. 2007
    ..we selected seven single-nucleotide polymorphisms (SNPs) out of the previously reported factors, namely, RANTES promoter -28G/-403A, RANTES In1...
  8. pmc Association between regulated upon activation, normal T cells expressed and secreted (RANTES) -28C/G polymorphism and asthma risk--a meta-analysis
    Qiaoqiao Fang
    Department of Respiratory Medicine, Nanjing Children s Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China
    Int J Med Sci 7:55-61. 2010
    Regulated upon activation, normal T-cell expressed and secreted (RANTES) is one of the most extensively studied C-C chemokines in allergic inflammation...
  9. pmc Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines
    A Trkola
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10021, USA
    J Virol 72:396-404. 1998
    ..of the inhibitory actions of the CC chemokines macrophage inhibitory protein 1alpha (MIP-1alpha), MIP-1beta, and RANTES against macrophage-tropic (M-tropic) primary isolates of human immunodeficiency virus type 1 (HIV-1) and of the ..
  10. doi CCL5/RANTES chemokine gene promoter polymorphisms are not associated with atopic and nonatopic asthma in a Spanish population
    M Muro
    Department of Immunology, University Hospital Virgen Arrixaca, Murcia, Spain
    Int J Immunogenet 35:19-23. 2008
    CCL5/RANTES, a member of the C-C chemokine family, is a potent eosinophil, monocyte, basophile and lymphocyte chemo-attractant at the site of inflammation...
  11. ncbi Plasma profiles of peripheral monocyte-related inflammatory markers in patients with arterial hypertension. Correlations with plasma endothelin-1
    John T Parissis
    Department of Cardiology, Athens Euroclinic, Greece
    Int J Cardiol 83:13-21. 2002
    ....
  12. ncbi Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1
    Huanliang Liu
    Department of Laboratory Medicine, University of Washington School of Medicine, 1959 N E Pacific Street, Seattle, WA 98195 8070, USA
    J Infect Dis 190:1055-8. 2004
    ..0%; P=.012). However, the CCR5-59029A, CCR2-64I, stromal cell-derived factor (SDF)-1-3'A, RANTES (regulated on activation, normally T cell-expressed and -secreted)-403A, and RANTES-28G polymorphisms were not ..
  13. ncbi RANTES gene polymorphisms predict all-cause and cardiac mortality in type 2 diabetes mellitus hemodialysis patients
    Carsten A Böger
    Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, D 93042 Regensburg, Germany
    Atherosclerosis 183:121-9. 2005
    ..Chemokines and their receptors are important in regulating leukocyte influx and activation in atherosclerosis, and functional polymorphisms in the respective genes are associated with cardiovascular disease risk...
  14. pmc beta-Chemokine production by neural and glial progenitor cells is enhanced by HIV-1 Tat: effects on microglial migration
    Yun Kyung Hahn
    Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia 23298 0709, USA
    J Neurochem 114:97-109. 2010
    ..Pathogens such as HIV might usurp this function to create a maladaptive state, especially during development or regeneration, when progenitors are numerous...
  15. pmc HIV-1 efficient entry in inner foreskin is mediated by elevated CCL5/RANTES that recruits T cells and fuels conjugate formation with Langerhans cells
    Zhicheng Zhou
    Mucosal Entry of HIV 1 and Mucosal Immunity, Cell Biology and Host Pathogen Interactions Department, Cochin Institute, CNRS UMR 8104, Paris, France
    PLoS Pathog 7:e1002100. 2011
    ..Our studies show that in the inner foreskin, inoculation with HIV-1-infected cells induces increased CCL5/RANTES (1.63-fold) and decreased CCL20/MIP-3-alpha (0.62-fold) secretion...
  16. ncbi CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms
    A O Kraaijeveld
    Department of Cardiology and Einthoven Laboratory of Experimental Vascular Medicine C5 P, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Circulation 116:1931-41. 2007
    ..Therefore, we assessed chemokine patterns in a prospective cohort of patients with UAP...
  17. pmc HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines
    Nazira El-Hage
    Department of Anatomy and Neurobiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0298, USA
    Glia 53:132-46. 2006
    ..Importantly, increased glial expression of MOR can trigger an opiate-driven amplification/positive feedback of MCP-1 production and inflammation...
  18. ncbi Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes
    A Zhernakova
    Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands
    Genes Immun 7:544-9. 2006
    b>RANTES (regulated on activation, normal T-cell expressed and secreted) is a T-helper type 1 (Th1) chemokine that promotes T-cell activation and proliferation...
  19. doi Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma
    William Murk
    Department of Epidemiology and Public Health, Yale University School of Public Health, New Haven, Conn, USA
    Hum Hered 71:97-105. 2011
    ..We sought to replicate an association between single nucleotide polymorphisms (SNPs) of the top-ranked candidate genes and childhood atopic asthma in Perinatal Risk of Asthma in Infants of Asthmatic Mothers (PRAM) study subjects...
  20. ncbi Expression of the duffy antigen/receptor for chemokines (DARC) by the inflamed synovial endothelium
    Angela M Patterson
    Centre for Science and Technology in Medicine, Keele University at Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK
    J Pathol 197:108-16. 2002
    ..Binding of radiolabelled chemokines IL-8, RANTES, MCP-1, but not MIP-1alpha, was found on venular endothelial cells in inflamed synovia from both rheumatoid and ..
  21. doi Interleukin-13 and RANTES polymorphisms in relation to asthma in children of Chinese Han nationality
    Quanhua Liu
    Pediatric Immunology Allergy, Tehran University of Medical Sciences, Hazrat Rasool Akram Hospital, Tehran Iran
    Asian Pac J Allergy Immunol 31:247-52. 2013
    IL-13 (interleukin-13) and RANTES (Regulated upon Activation, Normal T cells Expressed and Secreted) are the important asthma inflammatory mediators.
  22. ncbi The RANTES -403G>A promoter polymorphism in Korean men: association with serum RANTES concentration and coronary artery disease
    Yangsoo Jang
    Cardiovascular Genome Center, Cardiovascular Hospital, Severance Hospital, Sinchon dong, Seodaemun gu, Seoul, South Korea
    Clin Sci (Lond) 113:349-56. 2007
    In the present study we investigated the association of the RANTES (regulated upon activation, normal T-cell expressed and secreted) -28C>G and -403G>A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary ..
  23. doi Association of IL-10 and CCL5 single nucleotide polymorphisms with tuberculosis in the Sudanese population
    Najwa Mhmoud
    Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan
    Trop Med Int Health 18:1119-27. 2013
    ..To investigate the genetic determinants for developing tuberculosis in Sudan...
  24. ncbi Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3
    A Ben-Baruch
    Laboratory of Molecular Immunoregulation, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Biol Chem 270:22123-8. 1995
    ..sequenced and found to be identical to the known C-C CKR1 or macrophage inflammatory protein-1 alpha (MIP1 alpha)/Rantes receptor...
  25. ncbi HIV-1 gp120 stimulates the production of beta-chemokines in human peripheral blood monocytes through a CD4-independent mechanism
    L Fantuzzi
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 166:5381-7. 2001
    ..enhancement of secretion of monocyte chemoattractant protein-1, macrophage inflammatory protein-1beta, and RANTES as well as a clear-cut increase in transcript accumulation...
  26. ncbi Differential production of RANTES and MCP-1 in synovial fluid from the inflamed human knee
    Pio Conti
    Immunology Division, University of Chieti School of Medicine, Via dei Vestini, 66013 Chieti, Italy
    Immunol Lett 80:105-11. 2002
    ..MCP-1, as well as RANTES mediate many different inflammatory diseases and are important in the recruitment of diverse leukocytes...
  27. ncbi Lack of association between atopic eczema/dermatitis syndrome and polymorphisms in the promoter region of RANTES and regulatory region of MCP-1
    G T Kozma
    Department of Genetics, Cell and Immunobiology, Semmelweis University Budapest, Budapest, Hungary
    Allergy 57:160-3. 2002
    ..Recently polymorphisms in the promoter region of RANTES (regulated on activation normal T cell expressed and secreted) and in the gene regulatory region of MCP-1 (..
  28. ncbi Fluorescence resonance energy transfer analysis of the RANTES polymorphisms -403G --> A and -28G --> C: evaluation of both variants as susceptibility factors to HIV type 1 infection in the Spanish population
    Raquel María Fernández
    Unidad de Genética Medica y Diagnóstico Prenatal, Hospitales Universitarios Virgen del Rocio, 41013 Seville, Spain
    AIDS Res Hum Retroviruses 19:349-52. 2003
    ..Two of these factors are located in the promoter region of the CCL5 gene, which encodes the RANTES (regulated on activation, normal T cells expressed and secreted) chemokine, an inhibitor agent for M-tropic HIV-1 ..
  29. ncbi Macrophages and lymphocytes differentially modulate the ability of RANTES to inhibit HIV-1 infection
    Eleanore Gross
    Immunology and Inflammation Center, North Shore LIJ Research Institute, New York, NY, USA
    J Leukoc Biol 74:781-90. 2003
    The beta-chemokines MIP-1alpha, MIP-1beta, and RANTES inhibit HIV-1 infection of CD4+ T cells by inhibiting interactions between the virus and CCR5 receptors...
  30. ncbi Regulation of RANTES/CCL5 expression in human astrocytes by interleukin-1 and interferon-beta
    Mee Ohk Kim
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurochem 90:297-308. 2004
    In the CNS, astrocytes are significant sources of RANTES/CCL5 (regulated upon activation, normal T cell expressed and secreted), a CC-chemokine with important biological function...
  31. ncbi Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis
    Lucia Conti
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena, 299, Rome 00161, Italy
    Immunobiology 209:99-115. 2004
    ..This paper provides an overview of the present knowledge on gp120 binding, signal transduction triggering and interference with macrophage and DC functions and it highlights the importance of this interaction in the pathogenesis of AIDS...
  32. ncbi Assessment of genetic effects of polymorphisms in the MCP-1 gene on serum MCP-1 levels and myocardial infarction in Japanese
    Naoharu Iwai
    Department of Epidemiology, National Cardiovascular Center, Suita, Japan
    Circ J 70:805-9. 2006
    ..The purpose of the present study was to investigate the possible involvement of CCL2 in the pathogenesis of atherosclerosis and MI in Japanese...
  33. pmc Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer
    Pablo Saenz-Lopez
    Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de las Nieves, Granada, Spain
    BMC Cancer 8:382. 2008
    ..The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk...
  34. pmc CCR5, RANTES and SDF-1 polymorphisms and mother-to-child HIV-1 transmission
    D A Katz
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    Int J Immunogenet 37:301-5. 2010
    ..we found no associations between maternal genetic polymorphisms in CCR5 (59029G/A, 59353T/C, 59356T/C, 59402G/A), RANTES (-403G/A) and SDF-1 (3'801G/A) and mother-to-child HIV-1 transmission; plasma, cervical and breastmilk viral loads;..
  35. ncbi Independent roles of monocyte chemoattractant protein-1, regulated on activation, normal T-cell expressed and secreted and fractalkine in the vulnerability of coronary atherosclerotic plaques
    Jifu Li
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Shandong, PR China
    Circ J 76:2167-73. 2012
    ..of monocyte chemoattractant protein-1 (MCP-1), Regulated on Activation, Normal T-cell Expressed and Secreted (RANTES) and fractalkine on the vulnerability of atherosclerotic plaques in patients with acute myocardial infarction (AMI)..
  36. ncbi Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5
    R J Nibbs
    Cancer Research Campaign Laboratories, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    J Biol Chem 272:12495-504. 1997
    ..of competition for 125I-murine MIP-1alpha on D6 was murine MIP-1alpha > human and murine MIP-1beta > human RANTES approximately JE > human MCP-3 > human MCP-1. Human MIP-1alpha and the alpha-chemokines did not compete...
  37. pmc Antibodies to several conformation-dependent epitopes of gp120/gp41 inhibit CCR-5-dependent cell-to-cell fusion mediated by the native envelope glycoprotein of a primary macrophage-tropic HIV-1 isolate
    F C Verrier
    Département de Virologie Moléculaire, Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 94:9326-31. 1997
    ..BX08 Env-mediated fusion was inhibited by the beta-chemokines RANTES (regulated upon activation, normal T cell expressed and secreted) and macrophage inflammatory proteins 1beta (MIP-..
  38. ncbi HIV-1 Vpr and anti-inflammatory activity
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 23:239-47. 2004
    ..These activities are worthy of further examination for control of hyperinflammatory and hyperproliferative conditions...
  39. ncbi Sphingosine 1-phosphate inhibits migration and RANTES production in human bronchial smooth muscle cells
    Tadayoshi Kawata
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi 371 8511, Japan
    Biochem Biophys Res Commun 331:640-7. 2005
    ..to S1P inhibited platelet-derived growth factor (PDGF)-induced migration and tumor necrosis factor-alpha-induced RANTES production...
  40. ncbi Regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 in follicular fluid accumulate differentially in patients with and without endometriosis undergoing in vitro fertilization
    Hong Xu
    Department of Gynecology and Obstetrics, University of Schleswig Holstein, Luebeck, Germany
    Fertil Steril 86:1616-20. 2006
    To compare the amount of regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 (MCP-1) in follicular fluid (FF) of patients with and without endometriosis and to determine their oocyte ..
  41. pmc RANTES, MCP-1, CCR2, CCR5, CXCR1 and CXCR4 gene polymorphisms are not associated with the outcome of hepatitis B virus infection: results from a large scale single ethnic population
    Jae Youn Cheong
    Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine, San 5 Wonchon Dong, Youngtong Gu, Suwon, Korea
    J Korean Med Sci 22:529-35. 2007
    ..We assessed polymorphisms in regulated and normal T-cell expressed and secreted (RANTES) at position -403, monocyte chemoattractant protein-1 (MCP-1) at position -2518, CCR2 V64I, CCR5 -2459, CXCR1 ..
  42. doi Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1
    Ute Raffetseder
    Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany
    Kidney Int 75:185-96. 2009
    ..YB-1 has a critical role in atherogenesis due to its regulatory effects on chemokine CCL5 (RANTES) gene transcription in vascular smooth muscle cells...
  43. doi Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells
    Shinichi Matsuzaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    J Immunol 185:4863-72. 2010
    ..Chemokines such as CCL5/RANTES are secreted from airway epithelium and play a key role in allergic airway inflammation...
  44. doi CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways
    Chun Yin Huang
    Department of Orthopaedic Surgery, China Medical University Beigang Hospital, Yun Lin County, Taiwan
    Biochem Pharmacol 77:794-803. 2009
    CCL5 (previously called RANTES) is in the CC-chemokine family and plays a crucial role in the migration and metastasis of human cancer cells. Besides, integrins are the major adhesive molecules in mammalian cells...
  45. ncbi In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
    G Scarlatti
    Unit of Immunobiology of HIV, DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Nat Med 3:1259-65. 1997
    Following the identification of the C-C chemokines RANTES, MIP-1alpha and MIP-1beta as major human immunodeficiency virus (HIV)-suppressive factors produced by CD8+ T cells, several chemokine receptors were found to serve as membrane co-..
  46. pmc Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: expression profile of pathogenetically relevant genes
    Alessia A Bettaccini
    Dipartimento di Scienze Cliniche e Biologiche, Universita dell Insubria, Varese, Italy
    BMC Microbiol 5:20. 2005
    ..The activity of two-exon (aa 1-101) and synthetic (aa 1-86) Tat was studied on mammary and amniotic epithelial cells cultured under low serum conditions...
  47. ncbi Preferential transmission and association of the -403 G --> A promoter RANTES polymorphism with atopic asthma
    S A Al-Abdulhadi
    Department of Child Health, University of Aberdeen, Royal Aberdeen Children Hospital, Aberdeen AB25 2ZG, Scotland, UK
    Genes Immun 6:24-30. 2005
    Asthma is a complex inherited disease. The study was undertaken to identify the association of RANTES promoter polymorphisms with atopy and asthma using family-based association tests (FBATs) and generation-specific case-control analyses...
  48. doi RANTES gene polymorphisms and asthma risk: A meta-analysis
    Yong gang Zhang
    Department of Respiratory Medicine, West China Medical School of Sichuan University, Chengdu, China
    Arch Med Res 41:50-8. 2010
    b>RANTES is a chemokine that assists the recruitment of inflammatory cells including eosinophils...
  49. ncbi The -403 G-->A promoter polymorphism in the RANTES gene is associated with atopy and asthma
    A A Fryer
    Lung Injury and Inflammation Group, Centre for Cell and Molecular Medicine, Keele University, North Staffordshire Hospital, UK
    Genes Immun 1:509-14. 2000
    ..Of these, the chemokine RANTES is responsible for the recruitment of inflammatory cells such as eosinophils and T-lymphocytes...
  50. ncbi Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 -2518 G/G genotype in CAD patients
    C Szalai
    Section of Molecular Immunology, Hungarian Academy of Sciences, Budapest, Hungary
    Atherosclerosis 158:233-9. 2001
    ..Recently polymorphisms in the gene regulatory region of MCP-1 and in the promoter region of RANTES have been found, which increase the expression of these chemokines...
  51. ncbi Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor
    Raffaella Bonecchi
    Department of Biomedical Sciences and Biotechnology, Section of General Pathology and Immunology, University of Brescia, Brescia, Italy
    J Immunol 172:4972-6. 2004
    ..By recognizing intact CCL22, but not its truncated variants, D6 expressed on lymphatic endothelial cells may regulate the traffic of CCR4-expressing cells, such as dendritic cells...
  52. ncbi Effects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese
    X Y Zhao
    Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China
    Eur J Immunogenet 31:179-83. 2004
    ..the occurrence of the single nucleotide polymorphisms (SNPs) -403A/G and -28C/G in the promoter region of RANTES in 1082 Chinese blood donors from northern and southern China and 249 HIV patients from southern China...
  53. ncbi Expression of CCL5 (RANTES) and CCR5 in prostate cancer
    Gayle G Vaday
    Department of Research, Northport Veterans Affairs Medical Center, Northport, New York 11768, USA
    Prostate 66:124-34. 2006
    Expression of the inflammatory chemokine CCL5 (RANTES) by tumor cells is thought to correlate with the progression of several cancers. CCL5 was shown to induce breast cancer cell migration, mediated by the receptor CCR5...
  54. pmc Lung adenocarcinoma invasion in TGFbetaRII-deficient cells is mediated by CCL5/RANTES
    A C Borczuk
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Oncogene 27:557-64. 2008
    ..We used a tumor cell invasion system to identify the chemokine CCL5 (RANTES, regulated on activation, normal T-cell expressed and presumably secreted) as a potential downstream mediator of ..
  55. doi RANTES/CCL5 gene polymorphisms, serum concentrations, and incident type 2 diabetes: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Christian Herder
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Institute at Heinrich Heine University, 40225 Dusseldorf, Germany
    Eur J Endocrinol 158:R1-5. 2008
    Regulated on activation, normal T-cell expressed and secreted (RANTES)/chemokine(C-C motif) ligand (CCL5) is expressed by adipocytes, and serum levels of RANTES are increased in obesity and type 2 diabetes...
  56. pmc RANTES release by human adipose tissue in vivo and evidence for depot-specific differences
    Rana Madani
    Centre for Clinical Pharmacology, Div of Medicine, University College London, 5 University St, London, UK WC1 6JJ
    Am J Physiol Endocrinol Metab 296:E1262-8. 2009
    ..This study aimed to evaluate release of regulated on activation, normal T cell expressed and secreted (RANTES) by human adipose tissue in vivo and ex vivo, in reference to monocyte chemoattractant protein-1 (MCP-1) and ..
  57. doi Gene-gene interaction between tuberculosis candidate genes in a South African population
    Erika de Wit
    Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology and the DST NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa
    Mamm Genome 22:100-10. 2011
    ..was assessed, focusing on 11 polymorphisms in nine genes (DC-SIGN, IFN-γ, IFNGR1, IL-8, IL-1Ra, MBL, NRAMP1, RANTES, and SP-D) that have been associated with TB, some repeatedly...
  58. doi CCL5 (RANTES) gene polymorphisms in pulmonary tuberculosis patients of south India
    P Selvaraj
    Department of Immunology, Tuberculosis Research Centre, Indian Council of Medical Research, Chennai, India
    Int J Immunogenet 38:397-402. 2011
    ....
  59. pmc RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies
    Christian Herder
    Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    PLoS ONE 6:e25734. 2011
    The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans...
  60. doi Genetic polymorphisms of CCL2, CCL5, CCR2 and CCR5 genes in Sahariya tribe of North Central India: an association study with pulmonary tuberculosis
    Gunja Mishra
    Centre for Genomics, Molecular and Human Genetics, Jiwaji University, Gwalior 474 011, India
    Infect Genet Evol 12:1120-7. 2012
    The association of genetic variants of chemokines, CCL2 [MCP-1 (monocyte chemoattractant protein-1)], CCL5 [RANTES (regulated on activation, normal T-cell expressed and secreted)] and their receptors CCR2 and CCR5, respectively, earlier ..
  61. ncbi Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses
    Emanuele Fanales-Belasio
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Immunol 168:197-206. 2002
    ..Thus, Tat can act as both Ag and adjuvant, capable of driving T cell-mediated immune responses...
  62. ncbi Enhanced production of MMP-1, MMP-3, MMP-13, and RANTES by interaction of chondrocytes with autologous T cells
    Hiroshi Nakamura
    Institute of Medical Science, St Marianna University, Sugao, 216 8512 Kawasaki, Japan
    Rheumatol Int 26:984-90. 2006
    ..The production of MMP-1, MMP-3, MMP-13, and regulated on activation, normal T expressed and secreted (RANTES) was enhanced by direct co-culture compared to indirect co-culture using Transwell...
  63. ncbi TNF-alpha inhibits HIV-1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C-C chemokine receptor 5 (CCR5) expression
    B R Lane
    Department of Internal Medicine, Graduate Program in Cellular and Molecular Biology, School of Public Health, University of Michigan Medical Center, Ann Arbor 48109, USA
    J Immunol 163:3653-61. 1999
    ..We now show that TNF-alpha treatment of PBM and AM increases the production of the C-C chemokine, RANTES. Immunodepletion of RANTES alone or in combination with macrophage inflammatory protein-1alpha and -1beta block ..
  64. ncbi Coreceptor usage and RANTES sensitivity of non-syncytium-inducing HIV-1 isolates obtained from patients with AIDS
    M Jansson
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    J Hum Virol 2:325-38. 1999
    ..We evaluated possible associations between virus coreceptor usage, sensitivity to inhibition by beta-chemokines, and disease progression of patients who continue to yield NSI isolates after developing AIDS...
  65. ncbi Activation of human microglial cells by HIV-1 gp41 and Tat proteins
    W S Sheng
    Department of Pharmacology, Institute for Brain and Immune Disorders, Minneapolis, Minnesota, 55404, USA
    Clin Immunol 96:243-51. 2000
    ..The results of this study suggest that HIV-1 Tat and gp41 proteins impact several key functions of microglial cells which could contribute to the neuropathogenesis of HIV-1...
  66. ncbi Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils
    S Struyf
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Eur J Immunol 31:2170-8. 2001
    ..LD78beta(3 - 70) competed tenfold more efficiently than LD78beta(1 - 70) with [125I] RANTES for binding to the CC chemokine receptors CCR5 and CCR1...
  67. ncbi Production of the chemokines monocyte chemotactic protein-1, regulated on activation normal T cell expressed and secreted protein, growth-related oncogene, and interferon-gamma-inducible protein-10 is induced by the Sendai virus in human and rat testicula
    Ronan Le Goffic
    GERM INSERM, U 435, Universite de Rennes I, Campus de Beaulieu, 35042 Rennes, Bretagne, France
    Endocrinology 143:1434-40. 2002
    ..The ability of the Sendai virus to induce chemokine production in somatic cells (mostly peritubular and Leydig cells) may therefore increase the recruitment of leukocytes to sites of infection...
  68. pmc Modulating influence on HIV/AIDS by interacting RANTES gene variants
    Ping An
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 99:10002-7. 2002
    b>RANTES (regulated on activation normal T cell expressed and secreted), a ligand for the CC chemokine receptor 5, potently inhibits HIV-1 replication in vitro...
  69. ncbi Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES
    Nieves Fernández
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas, and Unidad de Investigacion, Hospital Clinico Universitario, Valladolid, Spain
    J Immunol 169:3321-8. 2002
    ..In contrast, RANTES mRNA was already detectable in resting cells and only increased after 16 h of stimulation...
  70. ncbi MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis
    E A Eugenin
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurochem 85:1299-311. 2003
    ..chemoattractant protein-1 (MCP-1 or CCL2) and regulated upon activation normal T cell expressed and secreted (RANTES) were found to protect mixed cultures of human neurons and astrocytes from tat or NMDA-induced apoptosis...
  71. ncbi Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages
    Hocine Slimani
    UPRES 3410, UFR SMBH, Universite Paris XIII, 74 rue Marcel Cachin, Hopital Jean Verdier, 93017 Bondy, Bobigny, France
    Biochim Biophys Acta 1617:80-8. 2003
    Interaction of RANTES with its membrane ligands or receptors transduces multiple intracellular signals...
  72. ncbi The correlation between monocyte chemoattractant protein-1 and the arthritis of systemic lupus erythematosus among Chinese
    Dong Qing Ye
    Department of Epidemiology and Biostatistics, Anhui Medical University, 69 Meishan Road, Hefei, 230032, Anhui, People s Republic of China
    Arch Dermatol Res 296:366-71. 2005
    ..The results indicate an association between the presence of G at position -2518 in the MCP-1 promoter region and the presence of arthritis in patients with SLE...
  73. ncbi HIV-1 viral protein R (Vpr) & host cellular responses
    Richard Yuqi Zhao
    Department of Pathology, University of Maryland School of Medicine, 10 South Pine Street, MSTF 600, Baltimore, MD 21201, USA
    Indian J Med Res 121:270-86. 2005
    ..Strategies with potential application for future antiviral therapies directed at suppressing Vpr activities are described...
  74. ncbi Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection
    Sadeep Shrestha
    Laboratory of Genomic Diversity, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, USA
    J Infect Dis 193:16-26. 2006
    ..The matched case-control study design with measured risk exposures provides an avenue for discovering genes involved in susceptibility to infection...
  75. ncbi Protective effects of IL4-589T and RANTES-28G on HIV-1 disease progression in infected Thai females
    Nuanjun Wichukchinda
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
    AIDS 20:189-96. 2006
    To evaluate the effect of polymorphisms in interleukin-4 (IL4) and RANTES promoters on disease progression in HIV-1 infected Thais.
  76. doi Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding
    Pia C Jensen
    Department of Neuroscience and Pharmacology, Copenhagen University, Blegdamsvej 3, DK 2200, Copenhagen, Denmark
    J Biol Chem 283:23121-8. 2008
    ....
  77. ncbi Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES
    T J Schall
    Genentech Inc, South San Francisco, California 94080
    Nature 347:669-71. 1990
    ..the C-X-C class of the superfamily and a group of cytokines produced by haematopoietic cells constitute the RANTES/sis or C-C class...
  78. ncbi A human T cell-specific molecule is a member of a new gene family
    T J Schall
    Department of Pediatrics, Stanford University School of Medicine, CA 94305
    J Immunol 141:1018-25. 1988
    ..We report here one such gene, designated RANTES, which encodes a novel T cell-specific molecule...
  79. ncbi Genomic organization and transcriptional regulation of the RANTES chemokine gene
    P J Nelson
    Department of Pediatrics, Stanford University School of Medicine, CA 94305
    J Immunol 151:2601-12. 1993
    b>RANTES is a member of a large supergene family of pro-inflammatory cytokines called CC chemokines that appear to play a fundamental role in inflammatory processes...
  80. ncbi Nuclear factor-kappa B potently up-regulates the promoter activity of RANTES, a chemokine that blocks HIV infection
    H Moriuchi
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 158:3483-91. 1997
    ..b>RANTES (regulated upon activation, normal T cell expressed and secreted) is a cytokine that belongs to the beta-chemokine ..
  81. ncbi RANTES and MIP-1alpha activate stats in T cells
    M Wong
    Department of Immunology, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    J Biol Chem 273:309-14. 1998
    The chemokines RANTES (regulated on activation, normal T cell expressed and secreted) and MIP (macrophage inflammatory protein)-1alpha have been implicated in regulating T cell functions...
  82. pmc Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression
    H Liu
    Department of Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 96:4581-5. 1999
    b>RANTES (regulated on activation normal T cell expressed and secreted) is one of the natural ligands for the chemokine receptor CCR5 and potently suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor...
  83. ncbi Aggregation of RANTES is responsible for its inflammatory properties. Characterization of nonaggregating, noninflammatory RANTES mutants
    V Appay
    British Biotech Pharmaceuticals Ltd, Watlington Road, Oxford OX4 5LY, United Kingdom
    J Biol Chem 274:27505-12. 1999
    The biology of RANTES (regulated on activation normal T cell expressed) aggregation has been investigated using RANTES and disaggregated variants, enabling comparison of aggregated, tetrameric, and dimeric RANTES forms...
  84. ncbi gp120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors
    M V Catani
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy
    J Neurochem 74:2373-9. 2000
    ..In addition, the alpha chemokine SDF1alpha and the beta chemokines MIP1alpha, MIP1beta, and RANTES, natural ligands of CXCR4 and CCR5, respectively, are potent soluble inhibitors of HIV infection by blocking the ..
  85. ncbi Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study
    D H McDermott
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    AIDS 14:2671-8. 2000
    To examine whether polymorphism in the RANTES gene is associated with HIV disease outcome.
  86. ncbi Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity
    C Szalai
    Heim Pál Pediatric Hospital, Budapest, Hungary
    J Allergy Clin Immunol 108:375-81. 2001
    ..Recently, polymorphisms in the gene regulatory region of monocyte chemoattractant protein 1 (MCP-1) and in the promoter region of RANTES have been found; these polymorphisms increase the expression of the chemokines.
  87. ncbi Polymorphism in RANTES chemokine promoter affects extent of sarcoidosis in a Japanese population
    T Takada
    Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Tissue Antigens 58:293-8. 2001
    b>RANTES, a member of C-C chemokine, is known to be produced at sites of granulomatous reactions in the lung of sarcoidosis...
  88. ncbi A functional polymorphism in the RANTES gene promoter is associated with the development of late-onset asthma
    Nobuyuki Hizawa
    First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Am J Respir Crit Care Med 166:686-90. 2002
    The CC chemokine regulated upon activation, normal T-cell expressed and secreted (RANTES) attracts eosinophils, basophils, and T cells during inflammation and immune response, indicating a possible role for this chemokine in asthma...
  89. ncbi Vpr- and Nef-dependent induction of RANTES/CCL5 in microglial cells
    Qiusheng Si
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Virology 301:342-53. 2002
    ..In addition, activation of microglia correlates best with clinical dementia. Although the beta-chemokine RANTES/CCL5 is important in modulating HIV infection as well as cellular activation, no information is available ..
  90. ncbi Mast cells in basal cell carcinoma express VEGF, IL-8 and RANTES
    Mikako Aoki
    Department of Dermatology, Nippon Medical School, Tokyo, Japan
    Int Arch Allergy Immunol 130:216-23. 2003
    ..The aim of this study was to elucidate the probable role of mast cells in BCC, especially focusing on the relationship between mast cells and lymphocytic infiltration as well as angiogenesis...
  91. ncbi Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection
    Simon Hellier
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Hepatology 38:1468-76. 2003
    ..The chemokine receptors CCR5, CCR2, and CCR3 and their ligands, RANTES, MCP-1, MCP-2, and MIP-1alpha, are involved in the immune responses and the selective recruitment of lymphocytes ..
  92. ncbi [Polymorphism of regulated upon activation, normal T cell expressed and secreted promoter region -28 position in Chinese allergic asthmatic children]
    Li Jun Wang
    Department of Clinical Examination, Tongren Hospital, Beijing 100730, China
    Zhonghua Jie He He Hu Xi Za Zhi 27:394-7. 2004
    To study the effect of regulated upon activation, normal T cell expressed and secreted (RANTES)-28 polymorphism on allergic asthma in Chinese children.
  93. ncbi Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosis
    Eleonora Simeoni
    Division of Cardiology, University of Lausanne, Switzerland
    Eur Heart J 25:1438-46. 2004
    Polymorphisms in the RANTES (G-403A), monocyte chemoattractant protein-1 (MCP-1; A-2518G), stromal cell-derived factor-1beta (SDF-1beta; G801A), and C-C chemokine receptor-5 (CCR5; Delta32) genes have been associated with functional ..
  94. ncbi RANTES: a genetic risk marker for multiple sclerosis
    Radhika Gade-Andavolu
    Genetic Research Institute of the Desert, Eisenhower Medical Center, Probst 308, 39000 Bob Hope Dr, Rancho Mirage, CA 92270, USA
    Mult Scler 10:536-9. 2004
    Regulated upon activation, normal T-cell expressed and secreted (RANTES) is a beta-chemokine and has been detected in brain lesions of multiple sclerosis (MS) patients...
  95. ncbi Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's disease
    Cecilia Huerta
    Genética Molecular IRSIN FRIAT, Hospital Central Asturias, Oviedo 33006, Spain
    Neurosci Lett 370:151-4. 2004
    ..We examined whether DNA-polymorphisms at the genes encoding chemokines MCP-1 (-2518 A/G) and RANTES (-403 A/G), and chemokine receptors 5 (CCR5, Delta32) and 2 (CCR2,V64I), were associated with the risk and/or the ..
  96. pmc Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat
    Nazira El-Hage
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Glia 50:91-106. 2005
    ..monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES), as well as interleukin-6 (IL-6)...
  97. ncbi RANTES G-401A polymorphism is associated with allergen sensitization and FEV1 in Chinese children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China
    Respir Med 99:216-9. 2005
    G-401A polymorphism in RANTES promoter was associated with near-fatal asthma and atopic dermatitis in children...
  98. pmc The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source
    C Goulding
    Department of Clinical Medicine and Dublin Molecular Medicine Centre, Trinity Centre for Health Sciences, St James Hospital, Ireland
    Gut 54:1157-61. 2005
    ..The aim of this study was to assess the involvement of inherited variations in CCR2, CCR5, and the ligand RANTES in determining disease outcome in hepatitis C virus (HCV) infected individuals.
  99. ncbi Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium
    Sebastian F Mause
    Department of Molecular Cardiovascular Research, University Hospital, Aachen, Germany
    Arterioscler Thromb Vasc Biol 25:1512-8. 2005
    Platelet activation mediates multiple cellular responses, including secretion of chemokines such as RANTES (CCL5), and formation of platelet microparticles (PMPs)...
  100. ncbi RANTES promoter polymorphism as a genetic risk factor for rheumatoid arthritis in the Chinese
    C R Wang
    Section of Rheumatology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Clin Exp Rheumatol 23:379-84. 2005
    There is increasing evidence suggesting a role of RANTES in the pathogenesis of rheumatoid arthritis (RA) and we evaluated the possible effect of RANTES gene on the susceptibility to RA in Chinese patients.
  101. ncbi Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans
    Ioannis Moissidis
    Allergy and Immunology Section, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Genet Med 7:406-10. 2005
    IL-13, RANTES (Regulated on Activation, Normal T cells Expressed and Secreted), and cysteinyl leukotrienes are asthma and atopy mediators...

Research Grants66

  1. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..domain of the CCR5 receptor, hR-421 binds and neutralizes all 3 CCR5-binding ligands (chemokines MIP-?, MIP-?, RANTES) and prevents their binding and activation of CCR1, CCR3, and CCR5...
  2. CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIV
    Catarina E Hioe; Fiscal Year: 2010
    ..e. CC chemokines MIP-1a, MIP-1[unreadable], and RANTES by the cells...
  3. Nicholas W Lukacs; Fiscal Year: 2016
    ..These mechanisms may be similar to those that are involved in infants, where RSV-infected children often progress into having longterm pulmonary problems and in asthmatics for exacerbated disease. ..
  4. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..Cytokines CXCL10, CXCL11, IL-7, RANTES and BAFF are induced 337, 45, 128, 84 and 119 fold, respectively, in synchronously infected ECs by 24 hrs p.i...
  5. TOMASZ K KORDULA; Fiscal Year: 2016
    ..via the activation of nuclear factor ?B, induction of several chemokines important for MS and EAE, such as RANTES and IP-10, requires the activation of an additional transcription factor, interferon regulatory factor-1 (IRF-1)...
  6. Genital Anaerobes, Inflammation and HIV Risk;Rakai
    LANCE BRADLEY PRICE; Fiscal Year: 2012
    ..multiplex sandwich ELISA (SearchLight, Aushon Biosystems, MA) for TNFa, IFN?, IL-1[unreadable], IL-8, IL-6, IL-12, RANTES, Monokine Induced by IFN? (MIG/CXCL9), Macrophage Chemotactic Protein (MCP1/CCL2), and Interferon Inducible ..
  7. Marcus Kaul; Fiscal Year: 2016
    ..IFN? induces in M? and microglia natural ligands of the HIV coreceptor CCR5, such as MIP-1??? and RANTES, which inhibit HIV-1 infection...
  8. Chaim Putterman; Fiscal Year: 2014
    ..Treatment of podocytes with TWEAK leads to increased expression of key pathogenic cytokines, including MCP-1, RANTES, VCAM-1, and IP-10...
  9. In Vivo Brain Dialysis of Neuropeptides and Neuroimmune Signaling Proteins
    Julie A Stenken; Fiscal Year: 2012
    ..of cytokines and neuropeptides related to epilepsy (cytokines {CCL2 [MCP-1], CCL3 [MIP-1a], CCL4 [MIP-12], CCL5 [RANTES], KC/GRO, IL-1b, IL-6, IL-10, and TNF-a} and neuropeptides {angiotensin IV, 2-amyloid, cholecystokinin, ..
  10. Role of Cocaine in Neuro-AIDS by HIV 1B and C Clades
    Madhavan P Nair; Fiscal Year: 2012
    ..cocaine on production and gene expression of pro-inflammatory cytokines, (TNF1 &IL-6), chemokines (MCP-1&RANTES), and neurotoxin (IDO) by primary monocytes and CNS cells (astrocytes, neurons, microglial cells), and whether :(..
  11. Madhavan P Nair; Fiscal Year: 2014
    ..C virus on production and gene expression of pro-inflammatory cytokines (TNF1 &IL-6), chemokines (MCP-1 &RANTES), and neurotoxin (IDO) by primary monocytes and CNS cells (astrocytes, microglial cells) and examine (Aim #1b), ..
  12. Inhibition of CCR1/CCR5 mediated angiogenesis and joint destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2010
    ..Importantly, RANTES/CCL5 and macrophage inflammatory protein (MIP-11)/CCL3 are the chemokines shown to activate CCR1 and CCR5 receptor ..
  13. CHEMOKINES AND IMMUNE DISEASES
    Lili Feng; Fiscal Year: 2000
    ..MIP-1 RA will target the "shared" C-C chemokine MIP-1/RANTES receptor involved in lymphocyte/monocyte attraction...
  14. CHEMOKINES AND HIV REPLICATION IN ALVEOLAR MACROPHAGES
    Michael Coffey; Fiscal Year: 2000
    ..Preliminary data from our laboratory suggest that the C-C chemokines, especially RANTES, reduce HIV replication in peripheral blood monocytes (PBM) and AM...
  15. Chemokine antagonists in a murine model for scleroderma
    Anita Gilliam; Fiscal Year: 2003
    ..chemokines such as macrophage chemoattractant protein (MCP-1/JE), macrophage inhibitory protein (MIP-1alpha) and RANTES are upregulated in Scl GVHD before accumulation of inflammatory cells and skin thickening...
  16. REGULATION OF CC CHEMOKINES IN HUMAN AIRWAY EPITHELIUM
    Cristiana Stellato; Fiscal Year: 2004
    ..airway epithelial cells are an important source of three major eosinophil-active chemokines, eotaxin, MCP-4, and RANTES, that glucocorticoids (GCs) inhibit production of these chemokines, and that both production and sensitivity to ..
  17. CHEMOKINES AND CHEMOKINE RECEPTORS IN SIV ENCEPHALITIS
    M Zink; Fiscal Year: 2003
    ..Chemokines play a dual role in down regulating viral replication and spread (MIP-1, MIP-l, and RANTES) and in upregulating inflammation through chemotaxis; the end result is chronic activation and neurodegeneration...
  18. T Cells, Macrophages, Chemokines, and Adiposopathy in Diet-Induced Obesity
    CHRISTIE MITCHELL BALLANTYNE; Fiscal Year: 2013
    ..that T cells are increased and the chemokine regulated on activation, normal T-cell expressed and secreted (RANTES) and its receptor, CCR5, along with monocyte chemoattractant protein-1 (MCP-1) and receptor CCR2, are upregulated ..
  19. Role of Darc-Chemokine Interaction in the Trafficking of Osteoclast Precursors
    Bouchra Edderkaoui; Fiscal Year: 2012
    ..marrow cells derived from Darc-knockout (Darc-KO) mice exhibit reduced binding to chemokines such as MCP-1 and RANTES;2) femurs isolated from Darc-KO mice showed reduced TRAP positive bone resorbing surface compared to control mice...
  20. ROLE OF CHEMOKINES IN T CELL MEDIATED COLITIS
    James Lillard; Fiscal Year: 2002
    ..In fact, human interleukin-8 (IL-8), IFN-gamma inducible protein - l0 (IP-l0), CXCR3 (the receptor for IP-10), RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted), and MCP-l/JE (monocyte chemotactic protein-1) ..
  21. Toby C Lewis; Fiscal Year: 2014
    ..nitric oxide (eNO), urinary 8-isoprostane, and nasal inflammatory cytokines (interleukin- 8/CXCL8, IP-10/CXCL10, RANTES/CCL5)...
  22. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..ecto domain of the CCR5 receptor, hR-421 binds and neutralizes al 3 CCR5-binding chemokine ligands (MIP-?, MIP-?, RANTES) and prevents their binding and activation of the CCR1, CCR3, and CCR5 membrane receptors...
  23. Evaluating self-protection of Th17 cells against HIV-1 by CCR5 Ligands Synthesis
    Yelina Alvarez; Fiscal Year: 2013
    ..We will also evaluate the capacity of Th17 cells to synthesize CCR5 ligands (MIP-1Beta, MIP-1alpha and RANTES), which are known to have potent anti-viral activity against CCR5-tropic isolates, the dominant viruses currently ..
  24. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..Additionally, chemokines (CCL3/MIP-11, CCL4/MIP-12, CXCL9/MIG, CXCL10/IP-10, CXCL12/SDF, and CCL5/RANTES) within these tissues will be examined to determine the extent of NK cell trafficking to the site of active viral ..
  25. JONATHAN MICHEAL SPERGEL; Fiscal Year: 2014
    ..epithelial cells (damage-associated molecular patterns, or DAMPs) can induce the expression of IL-8, ICAM-1, and RANTES through TLR2 and TLR3-dependent signal transduction pathways in the absence of pathogenic stimulation...
  26. Kalipada Pahan; Fiscal Year: 2016
    ..However, the mechanism behind disease progression is poorly understood. We hypothesize that RANTES and eotaxin could hold the key for driving disease progression and that targeting these two chemokines may be an ..
  27. CCR5 and CXCR4 Binding Chemokines and Oral HIV Infection
    Grace John Stewart; Fiscal Year: 2005
    ..The goal of the proposed study is to determine whether the CC and CXC chemokines (MIP-1?, MIP-1?, RANTES, and SDF-1) protect against intrapartum and breastmilk HIV-1 transmission...
  28. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010
    ..the coat glycoprotein gp120 of HIV, acting through the CXCR4 receptor can: 1) stimulate Schwann cells to release RANTES and then induce release of tumor necrosis factor alpha (TNF1) from dorsal root ganglion (DRG) neuron;and 2) ..
  29. FUNCTIONAL DIVERSITY OF ORBITAL FIBROBLASTS
    Terry J Smith; Fiscal Year: 2011
    ..GD-lgG/IGF-1R interactions result in the synthesis of powerful T cell chemoattractants, IL-16 and RANTES. Patients with TAO also have more IGF-1R expressing fibroblast precursors (fibrocytes) in their blood...
  30. Jessie Yester; Fiscal Year: 2014
    ..Completion of these aims will establish whether activation of IRF-1, CXCL10, and CCL5 contributes to GBM development and progression. It may also lead to new targets for the development of therapies in the future. ..
  31. Alveolar type II cell innate immune response to influenza
    ROBERT JAMES MASON; Fiscal Year: 2013
    ..interferon response with a focus on IL-29 and the cytokine inflammatory response with a focus on CXCL10, CXCL11, RANTES, and IL-6...
  32. Kevin D Cooper; Fiscal Year: 2014
    ..suppress in developed psoriatic lesions, have decreased numbers of CCR5+ Tregs, decreased chemotaxis to Rantes and Mip1a, decreased CD73, and increased IFI27 (ISG12)...
  33. ROLE OF TNF IN BLADDER INFLAMMATION
    David J Klumpp; Fiscal Year: 2010
    ..We find that bladder pathology requires expression of RANTES, a mast cell chemokine that is induced in the urothelium by tumor necrosis factor alpha (TNF)...
  34. CLINICAL/EXPERIMENTAL RADIATION RESEARCH
    Paul Okunieff; Fiscal Year: 2002
    ..chemoattractant proteins MCP-1, MCP-2, MCP-3, the macrophage inflammatory proteins MIP-1alpha, MIP-1beta, and RANTES--all of which have inflammatory activities...
  35. CC CHEMOKINES AND HUMAN CYTOMEGALOVIRUS PNEUMONITIS
    G Worthen; Fiscal Year: 2002
    ..During infection of the endothelium, HCMV-induced mechanisms stimulate the expression of the chemokine RANTES. Furthermore, HCMV encodes a G-protein coupled receptor, US28, that binds and signals through CC chemokines and is ..
  36. A Tool for Modeling the Structure-Activity of Chemokine Receptors and Other GPCRs
    BENJAMIN DORANZ; Fiscal Year: 2009
    ..CCR5 molecular interactions, including critical amino acids responsible for interacting with a chemokine (RANTES), two monoclonal antibodies (2D7 and 45523), HIV-1 Env (JRFL), and a small- molecule drug (TAK-779)...
  37. INACTIVATION OF CHEMOKINE RECEPTORS BY INTRAKINES
    Si Yi Chen; Fiscal Year: 2004
    ..hypothesis of this study is that intrakines able to specifically down-regulate CCR5 can be generated by modifying RANTES-intrakine or using a chemokine MIP-1B which specifically binds to CCR5, and transduced into human lymphocytes to ..
  38. Covalently Tethered Chemokines and HIV-1 Inhibition
    Wuyuan Lu; Fiscal Year: 2005
    ..coreceptors, such as the CXCR4- specific stromal cell-derived factor-1alpha (SDF-1alpha) and the CCR5-specific RANTES, MIP-1alpha and MIP-1beta, are potent inhibitors of HIV-1 infection...
  39. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..p70), IL-13, IL-15, IL-17, IP-10, KC, LIF, LIX, MCP-1, M-CSF, MIG, MIP-1[unreadable], MIP-1[unreadable], MIP-2, RANTES, TNF-[unreadable], and VEGF...
  40. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    ..the level of antioxidant enzyme Superoxide Dismutase, and reduces pro-inflammatory factors TNF-alpha, MCP-1, and RANTES. Recently, we further identified the active component of AX-3...
  41. Ann Richmond; Fiscal Year: 2016
    ....
  42. Basic and Comparative Studies of CCR5 Inhibition to Prevent HIV Transmission
    MICHAEL MARCEL LEDERMAN; Fiscal Year: 2010
    ..We have been developing RANTES analogues that block OCRS and inhibit HIV replication at subnanomolar concentrations...
  43. Interferon Regulatory Factors and Periodontal Disease
    Frank C Gibson; Fiscal Year: 2012
    ..IFN)-1, as well as the interferon-induced protein Regulated upon Activation Normal T cell Expressed and Secreted (RANTES) has been detected in human PD tissues...
  44. Chemokine Modulation of Airway Vagal Sensory Nerves
    CARL ROBERT POTENZIERI; Fiscal Year: 2011
    ..during both allergic and viral airway disease, "regulated upon activation, normal T-cell expressed and secreted" (RANTES), also known as CC chemokine ligand-5 (CCL5), has on the excitability of bronchopulmonary C-fibers...
  45. David L Bartlett; Fiscal Year: 2015
    ..The significance of the A34R deletion with enhanced release of the vvDD will be important for all poxvirus clinical applications. ..
  46. Influence of Sex Steroids on HIV-1 Chemokine Coreceptor Expression in Women
    Amie L Meditz; Fiscal Year: 2013
    ..Ultimately, this information is needed to develop rational standard practices of prescribing hormonal therapies to HIV infected women at all stages of life. ..
  47. Regulation of the miRNA-directed Reprogramming of Normal Omental Fibroblasts
    FREDERICK KOHLHAPP; Fiscal Year: 2013
    ....
  48. PLATELET REGULATION OF MONOKINE SYNTHESIS
    ANDREW WEYRICH; Fiscal Year: 2000
    ..Initial results indicate that P-selectin and RANTES (Regulated upon Activation Normal T Cell Expressed presumed Secreted), two platelet-derived molecules, are ..
  49. Control of HIV drug resistance in older patients
    Alonso Heredia; Fiscal Year: 2010
    ..Successful proof of this hypothesis will suggest CCR5 internalization (i.e., using RANTES analogs) and inhibition of expression (i.e...
  50. Karl A Nath; Fiscal Year: 2015
    ..As our findings in the AVF suggest that MCP-1 may exert its adverse effects via RANTES (CCL5), the role of CCL5 in AVF failure will be examined using CCL5-/- mice and a CCL5 inhibitor...
  51. Development of a Live Combinational Microbicide for Women
    Qiang Xu; Fiscal Year: 2010
    ..constitutively secrete the N-terminally modified CV-N (P51G) and an effective CCR5- targeted entry inhibitor, C1C5-RANTES. The latter is an N-terminally modified RANTES that targets the major HIV co-receptor CCR5 with an increased ..
  52. David A Thorley-Lawson; Fiscal Year: 2014
    ..2. To study the role of the chemokine CCL5 (RANTES) in mediating epithelial and NPC tumor cell migration, invasion and metastasis. 3...
  53. Maria Cecilia Garibaldi Marcondes; Fiscal Year: 2016
    ..cells is to change the balance of reactive oxygen species (ROS) and induce inflammatory markers, such as CCR5 and RANTES. These changes are believed to be dopamine-dependent, but we have observed that both ROS and CCR5 can be induced ..
  54. Stress and Platelet NPY in Vascular Remodeling
    John W Osborn; Fiscal Year: 2012
    ..DPPIV/cd26 (Aim 1/3B), which inactivates NPY- Y1R-mediated and monocytic chemoattractant activities of RANTES and SDF-1 (Aim 1B)...
  55. AIDS-Restrictive Innate Immune Mechanisms
    William H Carr; Fiscal Year: 2011
    ..g., interferon-y, MIP-1a &(3, and RANTES) as well as by cell-killing assays...
  56. ADENOVIRUS FLT3 LIGAND INDUCES NALT DCs FOR SALIVARY GLAND S-lgA Ab RESPONSES
    Kohtaro Fujihashi; Fiscal Year: 2010
    ..We have shown that plasmids encoding the flt3 ligand (FL), lymphotactin (LTN), RANTES and MCP-1 cDNA as well as unmethylated cytosine-guanine dinucleotides oligodeoxynucleotide (CpG ODN), when used as ..
  57. Leukocyte Signaling in Virus-Induced Asthma Exacerbation
    David Hall; Fiscal Year: 2009
    ..involvement of key signaling events in RV-stimulated mediator production by the macrophage, specifically, MCP-1, RANTES and IFN-a...
  58. OXIDANT INDUCED BETA CHEMOKINES IN GRANULOMA FORMATION
    Jeffrey Warren; Fiscal Year: 2000
    ..Regulated upon Activation, Normal T-cell Expressed and presumably Secreted (RANTES), macrophage inflammatory protein 1alpha (MIP-1alpha), and MIP 1beta...
  59. CYTOKINE GENE EXPRESSION BY VIRUS IN GLIAL CELLS
    MOON SHIN; Fiscal Year: 2000
    ..by which neurotropic viruses induce cytokine and chemokine gene expression in glial cells by studying TNF and RANTES genes. Pro-inflammatory cytokine TNF is a potent effector in primary demyelination...
  60. VIRAL EXACERBATIONS OF ASTHMA
    Scherer Sanders; Fiscal Year: 2002
    ..test the hypothesis that virus induced production of the eosinophil chemotactic and activating cytokines, eotaxin, RANTES, and granulocyte-macrophage colony stimulating factor (GM-CSF) from infected epithelial cells plays a central role ..
  61. Allergic Condition Biomarkers and Glioma Risk
    Judith Schwartzbaum; Fiscal Year: 2004
    ..Gene products of genetic polymorphisms found on the IL-4, IL-13, IL-4Ralpha, IL-13Ralpha1, HLA -DRB1, RANTES, and neuronal nitric oxide synthase (nNOS) play a role in both ACs and the brain...
  62. Opioid Binding to U51: A Human herpes Virus Protein
    Jean Bidlack; Fiscal Year: 2002
    ..HHV-6 U51 is a chemokine receptor, which binds the chemokine RANTES, and other beta chemokines, such as eotaxin, monocyte chemoattractant protein 1, 3, and 4...
  63. TNT: Targeting and Triggering Adjuvancy of DNA Vaccines
    Michele Kutzler; Fiscal Year: 2005
    ..a specific immunization protocol in which vaccination with combinations of DNA constructs encoding the chemokines RANTES, IL-8, or CTACK, and/or a novel B7DeltaC-domain costimulatory protein results in an enhanced antigen specific cell ..
  64. MECHANISM OF REGULATION OF HIV-1 INFECTION BY CHEMOKINES
    Helena Schmidtmayerova; Fiscal Year: 2003
    ..large body of work has demonstrated that the natural ligands of CCR5 (beta-chemokines; MIP-1alpha, MIP-1beta, and RANTES) inhibit HIV-1 replication in lymphocytes, our results demonstrated an enhancing rather than an inhibitory effect ..
  65. Effect of DC-SIGNR Polymorphisms on HIV-1 Infection
    Tuofu Zhu; Fiscal Year: 2003
    ..individuals were investigated for such known polymorphisms including CCR5-A32, CCR5 promoter, CCR2-641, SDF-1-3'A, RANTES -403A and -28G...
  66. MECHANISMS OF CHEMOKINE-INDUCED INFLAMMATION IN HUMANS
    Lisa Beck; Fiscal Year: 2005
    ..We have developed an in vivo chemokine challenge model with which we characterized the tissue response to RANTES in humans...