RASA1

Summary

Gene Symbol: RASA1
Description: RAS p21 protein activator 1
Alias: CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120, p120GAP, p120RASGAP, ras GTPase-activating protein 1, RAS p21 protein activator (GTPase activating protein) 1, p120 RAS GTPase activating protein, triphosphatase-activating protein
Species: human
Products:     RASA1

Top Publications

  1. Hecker T, Ding Q, Rege T, Hanks S, Gladson C. Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells. Oncogene. 2004;23:3962-71 pubmed
    ..The overexpression of FAK also promoted the association of FAK with p120RasGAP, which is a negative regulator of Ras activity, in the U-251MG cells cultured in aggregate suspension, with this ..
  2. Kazlauskas A, Ellis C, Pawson T, Cooper J. Binding of GAP to activated PDGF receptors. Science. 1990;247:1578-81 pubmed
    ..products appear to relay intracellular signals via the Ras guanosine triphosphatase (GTPase) activator protein, GAP. In dog epithelial cells expressing human platelet-derived growth factor (PDGF) receptors, binding of PDGF caused ..
  3. Tomar A, Lim S, Lim Y, Schlaepfer D. A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci. 2009;122:1852-62 pubmed publisher
    ..and carcinoma polarity during cell migration requires FAK and is associated with a complex between FAK, p120RasGAP and p190RhoGAP (p190A), leading to p190A tyrosine phosphorylation...
  4. Boon L, Mulliken J, Vikkula M. RASA1: variable phenotype with capillary and arteriovenous malformations. Curr Opin Genet Dev. 2005;15:265-9 pubmed
    ..Candidate gene screening pinpointed mutations in RASA1 (p120-RASGAP) - a RasGTPase. RASA1 reverts active GTP-bound Ras into inactive GDP-bound form...
  5. Yang J, Michod D, Walicki J, Murphy B, Kasibhatla S, Martin S, et al. Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions. Mol Cell Biol. 2004;24:10425-36 pubmed
    ..This mechanism relies on the partial cleavage of RasGAP by caspase 3 into an amino-terminal fragment called fragment N...
  6. Koch C, Moran M, Anderson D, Liu X, Mbamalu G, Pawson T. Multiple SH2-mediated interactions in v-src-transformed cells. Mol Cell Biol. 1992;12:1366-74 pubmed
    ..and transforming proteins, including cytoplasmic protein-tyrosine kinases and Ras GTPase-activating protein (GAP)...
  7. Kulkarni S, Gish G, van der Geer P, Henkemeyer M, Pawson T. Role of p120 Ras-GAP in directed cell movement. J Cell Biol. 2000;149:457-70 pubmed
    We have used cell lines deficient in p120 Ras GTPase activating protein (Ras-GAP) to investigate the roles of Ras-GAP and the associated p190 Rho-GAP (p190) in cell polarity and cell migration...
  8. Druker B, Okuda K, Matulonis U, Salgia R, Roberts T, Griffin J. Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines. Blood. 1992;79:2215-20 pubmed
    ..We report here that p21ras GTPase activating protein (rasGAP) or rasGAP-associated proteins p190 and p62 are phosphorylated on tyrosine in Ph1 (+) cell lines...
  9. Yang J, Walicki J, Abderrahmani A, Cornu M, Waeber G, Thorens B, et al. Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion. J Biol Chem. 2005;280:32835-42 pubmed
    ..b>RasGAP, a regulator of Ras and Rho GTPases, is an atypical caspase substrate, since it inhibits, rather than favors, ..
  10. Eerola I, Boon L, Mulliken J, Burrows P, Dompmartin A, Watanabe S, et al. Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations. Am J Hum Genet. 2003;73:1240-9 pubmed
    ..A positional candidate gene, RASA1, encoding p120-RasGAP, was screened for mutations in 17 families...

Detail Information

Publications62

  1. Hecker T, Ding Q, Rege T, Hanks S, Gladson C. Overexpression of FAK promotes Ras activity through the formation of a FAK/p120RasGAP complex in malignant astrocytoma cells. Oncogene. 2004;23:3962-71 pubmed
    ..The overexpression of FAK also promoted the association of FAK with p120RasGAP, which is a negative regulator of Ras activity, in the U-251MG cells cultured in aggregate suspension, with this ..
  2. Kazlauskas A, Ellis C, Pawson T, Cooper J. Binding of GAP to activated PDGF receptors. Science. 1990;247:1578-81 pubmed
    ..products appear to relay intracellular signals via the Ras guanosine triphosphatase (GTPase) activator protein, GAP. In dog epithelial cells expressing human platelet-derived growth factor (PDGF) receptors, binding of PDGF caused ..
  3. Tomar A, Lim S, Lim Y, Schlaepfer D. A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci. 2009;122:1852-62 pubmed publisher
    ..and carcinoma polarity during cell migration requires FAK and is associated with a complex between FAK, p120RasGAP and p190RhoGAP (p190A), leading to p190A tyrosine phosphorylation...
  4. Boon L, Mulliken J, Vikkula M. RASA1: variable phenotype with capillary and arteriovenous malformations. Curr Opin Genet Dev. 2005;15:265-9 pubmed
    ..Candidate gene screening pinpointed mutations in RASA1 (p120-RASGAP) - a RasGTPase. RASA1 reverts active GTP-bound Ras into inactive GDP-bound form...
  5. Yang J, Michod D, Walicki J, Murphy B, Kasibhatla S, Martin S, et al. Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions. Mol Cell Biol. 2004;24:10425-36 pubmed
    ..This mechanism relies on the partial cleavage of RasGAP by caspase 3 into an amino-terminal fragment called fragment N...
  6. Koch C, Moran M, Anderson D, Liu X, Mbamalu G, Pawson T. Multiple SH2-mediated interactions in v-src-transformed cells. Mol Cell Biol. 1992;12:1366-74 pubmed
    ..and transforming proteins, including cytoplasmic protein-tyrosine kinases and Ras GTPase-activating protein (GAP)...
  7. Kulkarni S, Gish G, van der Geer P, Henkemeyer M, Pawson T. Role of p120 Ras-GAP in directed cell movement. J Cell Biol. 2000;149:457-70 pubmed
    We have used cell lines deficient in p120 Ras GTPase activating protein (Ras-GAP) to investigate the roles of Ras-GAP and the associated p190 Rho-GAP (p190) in cell polarity and cell migration...
  8. Druker B, Okuda K, Matulonis U, Salgia R, Roberts T, Griffin J. Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines. Blood. 1992;79:2215-20 pubmed
    ..We report here that p21ras GTPase activating protein (rasGAP) or rasGAP-associated proteins p190 and p62 are phosphorylated on tyrosine in Ph1 (+) cell lines...
  9. Yang J, Walicki J, Abderrahmani A, Cornu M, Waeber G, Thorens B, et al. Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion. J Biol Chem. 2005;280:32835-42 pubmed
    ..b>RasGAP, a regulator of Ras and Rho GTPases, is an atypical caspase substrate, since it inhibits, rather than favors, ..
  10. Eerola I, Boon L, Mulliken J, Burrows P, Dompmartin A, Watanabe S, et al. Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations. Am J Hum Genet. 2003;73:1240-9 pubmed
    ..A positional candidate gene, RASA1, encoding p120-RasGAP, was screened for mutations in 17 families...
  11. Scheffzek K, Ahmadian M, Kabsch W, Wiesmuller L, Lautwein A, Schmitz F, et al. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science. 1997;277:333-8 pubmed
    ..diphosphate and the guanosine triphosphatase (GTPase)-activating domain of the human GTPase-activating protein p120GAP (GAP-334) in the presence of aluminum fluoride was solved at a resolution of 2.5 angstroms...
  12. Ellis C, Moran M, McCormick F, Pawson T. Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature. 1990;343:377-81 pubmed
    ..The presence of two adjacent SH2 domains in the p21ras GTPase-activating protein (GAP) indicates that GAP might interact directly with tyrosine kinases...
  13. Hu K, Settleman J. Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation. EMBO J. 1997;16:473-83 pubmed
    ..p120 RasGAP (GTPase-activating protein), which contains an SH3 domain flanked by two SH2 domains, forms an abundant SH2-..
  14. Bradley W, Hernandez S, Settleman J, Koleske A. Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane. Mol Biol Cell. 2006;17:4827-36 pubmed
    ..p190 phosphorylation promotes its binding to p120RasGAP (p120). Here, we elucidate the mechanism by which p120 binding regulates p190 activation after adhesion...
  15. Pamonsinlapatham P, Gril B, Dufour S, Hadj Slimane R, Gigoux V, Pethe S, et al. Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration. Cell Signal. 2008;20:2119-26 pubmed publisher
    Ras GTPase-activating protein (RasGAP) is hypothesized to be an effector of oncogenic Ras stimulating numerous downstream cellular signaling cascades involved in survival, proliferation and motility...
  16. Settleman J, Narasimhan V, Foster L, Weinberg R. Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus. Cell. 1992;69:539-49 pubmed
    ..stimulated and tyrosine kinase-transformed cells, a substantial fraction of the ras GTPase-activating protein (GAP) forms a complex with a protein termed p190. We have cloned several cDNAs encoding the p190 protein...
  17. Annibaldi A, Dousse A, Martin S, Tazi J, Widmann C. Revisiting G3BP1 as a RasGAP binding protein: sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1. PLoS ONE. 2011;6:e29024 pubmed publisher
    b>RasGAP is a multifunctional protein that controls Ras activity and that is found in chromosomal passenger complexes. It also negatively or positively regulates apoptosis depending on the extent of its cleavage by caspase-3...
  18. Sanz R, Clares B, Mallandrich M, Suñer Carbó J, Montes M, Calpena A. Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief associated with gynecological surgery. Int J Pharm. 2017;535:393-401 pubmed publisher
    ..Therefore, we can hypostatize that the proposed formulation may assist to fill in the therapeutic gap regarding pure pain relief at local level in vagina.
  19. Kumar A, Sevilla M. SOMO-HOMO Level Inversion In Biologically Important Radicals. J Phys Chem B. 2017;: pubmed publisher
    ..spin density in σ-orbital on a single atom (carbon, nitrogen, oxygen, sulfur or selenium) the greater the gap between HOMO and SOMO...
  20. Goel N, Alam A, Eggert E, Acharya S. Design and development of a customizable telemedicine platform for improving access to healthcare for underserved populations. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:2658-2661 pubmed publisher
    Telemedicine offers a method to bridge the healthcare access gap in low and middle income countries (LMICs) by connecting providers with patients using appropriate technology...
  21. Liang X, Zha J, Martyniuk C, Wang Z, Zhao J. Histopathological and proteomic responses in male Chinese rare minnow (Gobiocypris rarus) indicate hepatotoxicity following benzotriazole exposure. Environ Pollut. 2017;229:459-469 pubmed publisher
    ..To address this knowledge gap, we measured the liver proteome of adult male Chinese rare minnow (Gobiocypris rarus) exposed to either 0.05, 0...
  22. Chae S. Parental Divorce and Children's Schooling in Rural Malawi. Demography. 2016;53:1743-1770 pubmed
    ..Results show that parental divorce is associated with lower grade attainment and a larger schooling gap, defined as the number of years a child is behind in school (among children currently attending school)...
  23. Gilbert F, Cook M, O BRIEN T, Illes J. Embodiment and Estrangement: Results from a First-in-Human "Intelligent BCI" Trial. Sci Eng Ethics. 2017;: pubmed publisher
    ..In this article, we address this knowledge gap by analysing data from the first-in-human clinical trial to study patients with implanted BCI advisory devices...
  24. Morris S, Naeve C, Mathew P, James P, Kirstein M, Cui X, et al. ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene. 1997;14:2175-88 pubmed
    ..Thus, ALK is a novel orphan receptor tyrosine kinase that appears to play an important role in the normal development and function of the nervous system. ..
  25. Henter H, Imondi R, James K, Spencer D, Steinke D. DNA barcoding in diverse educational settings: five case studies. Philos Trans R Soc Lond B Biol Sci. 2016;371: pubmed publisher
    Despite 250 years of modern taxonomy, there remains a large biodiversity knowledge gap. Most species remain unknown to science...
  26. Aguilar Palacio I, Carrera Lasfuentes P, Sánchez Recio R, Alonso J, Rabanaque M. Recession, employment and self-rated health: a study on the gender gap. Public Health. 2017;154:44-50 pubmed publisher
    ..We analysed the effects of the Spanish economic recession in terms of self-rated health, its differential effect among genders and its influence on gender gap.
  27. Shkir M, Alfaify S. Tailoring the structural, morphological, optical and dielectric properties of lead iodide through Nd3+ doping. Sci Rep. 2017;7:16091 pubmed publisher
    ..The energy band gap was calculated and found to be 3.35, 3.34, 3.42 and 3...
  28. Xu X, Wen X, Veltman D, Keizer Gunnink I, Pots H, Kortholt A, et al. GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis. Proc Natl Acad Sci U S A. 2017;114:E10092-E10101 pubmed publisher
    ..We show that both C2 and GAP domains are required for the membrane targeting of C2GAP1, and that GPCR-triggered Ras activation is necessary to ..
  29. Liu P, PENA E. Sojourning with the Homogeneous Poisson Process. Am Stat. 2016;70:413-423 pubmed publisher
    ..Properties of the gap-time that covered the termination time and the correlations among gap-times of the observed events are obtained...
  30. Torabinejad M, Nosrat A, Verma P, Udochukwu O. Regenerative Endodontic Treatment or Mineral Trioxide Aggregate Apical Plug in Teeth with Necrotic Pulps and Open Apices: A Systematic Review and Meta-analysis. J Endod. 2017;43:1806-1820 pubmed publisher
    ..Randomized multicenter clinical trials with large sample sizes and long-term follow-ups are needed to address this gap in knowledge.
  31. Janssen A, Robinson T, Provan P, Shaw T. The Sydney West Knowledge Portal: Evaluating the Growth of a Knowledge Portal to Support Translational Research. J Med Internet Res. 2016;18:e170 pubmed publisher
    ..One solution to addressing this gap is the design and deployment of web-based knowledge portals to disseminate new knowledge and engage with and ..
  32. Iyikanat F, Kandemir A, Ozaydin H, Senger R, Sahin H. Hydrogenation-driven phase transition in single-layer TiSe2. Nanotechnology. 2017;28:495709 pubmed publisher
    ..Fully hydrogenated TiSe2 presents a direct gap semiconducting behavior with a band gap of 119 meV...
  33. Márquez Luna C, Loh P, Price A. Multiethnic polygenic risk scores improve risk prediction in diverse populations. Genet Epidemiol. 2017;41:811-823 pubmed publisher
    ..Our work reduces the gap in polygenic risk prediction accuracy between European and non-European target populations.
  34. Camomilla V, Cereatti A, Cutti A, Fantozzi S, Stagni R, Vannozzi G. Methodological factors affecting joint moments estimation in clinical gait analysis: a systematic review. Biomed Eng Online. 2017;16:106 pubmed publisher
    ..This article aims at filling this gap through a systematic review of the literature, conducted on Web of Science, Scopus and PubMed...
  35. Zhou M, Zeng C, Song Y, Padelford J, Wang G, Sfeir M, et al. On the Non-Metallicity of 2.2 nm Au246 (SR)80 Nanoclusters. Angew Chem Int Ed Engl. 2017;: pubmed publisher
    ..analysis of the oscillation suggests that it arises from the wavepacket motion on the ground state potential energy surface, which also indicates the presence of a small band-gap and thus non-metallic or molecular-like behaviour.
  36. Rosapep L, Sanders E, Banke K. The influence of customer-medicine seller transactional dynamics on childhood diarrhoea management: a qualitative study in Ghana. Health Policy Plan. 2017;32:527-537 pubmed publisher
    ..In many countries, however, a significant knowledge-practice gap persists in appropriate diarrhoea management among private healthcare providers...
  37. Wheat H, Goodwin A. Tactile discrimination of gaps by slowly adapting afferents: effects of population parameters and anisotropy in the fingerpad. J Neurophysiol. 2000;84:1430-44 pubmed
    ..We quantified the ability of humans to discriminate small differences in gap width using a forced-choice task...
  38. Shafiq M, Naeem M, Munawar Z, Fatima I. Service Quality Assessment of Hospitals in Asian Context: An Empirical Evidence From Pakistan. Inquiry. 2017;54:46958017714664 pubmed publisher
    ..assurance were ranked first, second, third, fourth, and fifth, respectively, in terms of the size of the quality gap. The gaps were statistically significant, with values ≤...
  39. Sullivan K, Evans D, Pandey A, Hraha T, Smith K, Markham N, et al. Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation. Sci Rep. 2017;7:14818 pubmed publisher
    ..To address this knowledge gap, we employed proteomics approaches to analyze blood samples from 263 individuals, 165 of them with DS, leading to ..
  40. Zaugg L, Meyer S, Rohr N, Zehnder I, Zitzmann N. Fracture behavior, marginal gap width, and marginal quality of vented or pre-cemented CAD/CAM all-ceramic crowns luted on Y-TZP implants. Clin Oral Implants Res. 2017;: pubmed publisher
    To investigate the fracture behavior and marginal gap region of CAD/CAM fabricated lithium disilicate (L) and zirconium dioxide (Z) crowns using palatal venting (PV), pre-cementation with custom analogs (CA), or conventional cementation ..
  41. Zhang X, Zhang X, Chen X. Happiness in the Air: How Does a Dirty Sky Affect Mental Health and Subjective Well-being?. J Environ Econ Manage. 2017;85:81-94 pubmed publisher
    ..This paper attempts to fill the gap by investigating the impact of air pollution on several key dimensions, including mental health status, depressive ..
  42. Wang Y, Duan T, Weng Z, Ling J, Yin X, Chen L, et al. Mild Periodic Acid Flux and Hydrothermal Methods for the Synthesis of Crystalline f-Element-Bearing Iodate Compounds. Inorg Chem. 2017;56:13041-13050 pubmed publisher
    ..features are observed in isotypic compounds 5-7, where 7 shows typical semiconductor behavior with a band gap of 2.43 eV. Remarkably, noncentrosymmetric 1, 6, and 7 exhibit strong second-harmonic-generation efficiencies of 1...
  43. Pelletier R, Akpovi C, Chen L, Vitale M. Cholesterol metabolism and Cx43, Cx46, Cx50 gap junction protein expression and localisation in normal and diabetic and obese ob/ob and db/db mouse testes. Am J Physiol Endocrinol Metab. 2017;:ajpendo.00215.2017 pubmed publisher
    ..Our findings indicate that the db mutation-induced impairment of meiosis may arise from imbalances in cholesterol metabolism and upregulated Cx43 expression and phosphorylation in tubules. ..
  44. Ketrat S, Maihom T, Wannakao S, Probst M, Nokbin S, Limtrakul J. Coordinatively Unsaturated Metal-Organic Frameworks M3(btc)2 (M = Cr, Fe, Co, Ni, Cu, and Zn) Catalyzing the Oxidation of CO by N2O: Insight from DFT Calculations. Inorg Chem. 2017;56:14005-14012 pubmed publisher
    ..This, in turn, is due to the smaller gap between the highest occupied molecular orbital (HOMO) of the MOF and the lowest unoccupied molecular orbital (LUMO)..
  45. Carey G, Dickinson H. A longitudinal study of the implementation experiences of the Australian National Disability Insurance Scheme: investigating transformative policy change. BMC Health Serv Res. 2017;17:570 pubmed publisher
    ..understanding of the Australian scheme and how individualised funding operates within this context, but will also generate much needed evidence that will have relevance to other jurisdictions and help fill a gap in the evidence base.
  46. Shen Y, Zhang S, Zhou J, Chen J. Cohort Research in "Omics" and Preventive Medicine. Adv Exp Med Biol. 2017;1005:193-220 pubmed publisher
    ..Cohort study can bridge the gap between the micro and macro research.This chapter is divided into three parts: 1...
  47. Gao L, Feng S, Liu Z, Wang J, Qi K, Wang K. A computational network analysis based on targets of antipsychotic agents. Schizophr Res. 2017;: pubmed publisher
    ..networks related with drug metabolism, Calcium signaling, GABA receptors, dopamine receptors, Bile secretion and Gap junction...
  48. Lambers E, Arnone B, Fatima A, Qin G, Wasserstrom J, Kume T. Foxc1 Regulates Early Cardiomyogenesis and Functional Properties of Embryonic Stem Cell Derived Cardiomyocytes. Stem Cells. 2016;34:1487-500 pubmed publisher
    ..pathways regulated by Foxc1 involved in cardiac function including actin cytoskeleton, cell adhesion, tight and gap junctions, and calcium signaling...
  49. Weng W, Lin K, Wu P, Ho Y, Liu Y, Wang B, et al. VEGF expression correlates with neuronal differentiation and predicts a favorable prognosis in patients with neuroblastoma. Sci Rep. 2017;7:11212 pubmed publisher
    ..In addition, the mRNA and protein levels of VEGF and differentiation marker GAP-43 were upregulated by induced CRT expression...
  50. de Abreu E Lima F, Westhues M, Cuadros Inostroza A, Willmitzer L, Melchinger A, Nikoloski Z. Metabolic robustness in young roots underpins a predictive model of maize hybrid performance in the field. Plant J. 2017;90:319-329 pubmed publisher
    ..Therefore, our findings demonstrated the potential of metabolic profiles from young maize roots grown under tightly controlled conditions to predict hybrid performance in multiple field trials, thus bridging the greenhouse-field gap.
  51. Hamilton H, Williams T, Ventura J, Jasperse L, Owens E, Miller G, et al. Clinical and Cognitive Significance of Auditory Sensory Processing Deficits in Schizophrenia. Am J Psychiatry. 2017;:appiajp201716111203 pubmed publisher
    ..The authors examined associations between P50 suppression deficits and several core features of schizophrenia to address this gap.
  52. Ramakreshnan L, Aghamohammadi N, Fong C, Bulgiba A, Zaki R, Wong L, et al. Haze and health impacts in ASEAN countries: a systematic review. Environ Sci Pollut Res Int. 2017;: pubmed publisher
    ..By addressing such gap, this review aimed to critically highlight the evidence of physical and psychological health impacts of haze from ..