RFC1

Summary

Gene Symbol: RFC1
Description: replication factor C subunit 1
Alias: MHCBFB, PO-GA, RECC1, RFC, RFC140, replication factor C subunit 1, A1 140 kDa subunit, DNA-binding protein PO-GA, MHC binding factor, beta, RF-C 140 kDa subunit, activator 1 140 kDa subunit, activator 1 large subunit, activator 1 subunit 1, replication factor C (activator 1) 1, 145kDa, replication factor C 140 kDa subunit, replication factor C large subunit, replication factor C1
Species: human

Top Publications

  1. ncbi Predictors of successful radiofrequency catheter ablation of sinoatrial tachycardia
    M Y Ivanov
    Clinical Electrophysiology Laboratory, Cardiosurgery Clinic, Emergency Hospital, Cheliabinsk, Russia
    Pacing Clin Electrophysiol 21:311-5. 1998
  2. ncbi Replication factor C from the hyperthermophilic archaeon Pyrococcus abyssi does not need ATP hydrolysis for clamp-loading and contains a functionally conserved RFC PCNA-binding domain
    Ghislaine Henneke
    IFREMER, Laboratoire de Microbiologie et Biotechnologie des Extrêmophiles, DRV VP, BP 70, F 29280 Plouzane, France
    J Mol Biol 323:795-810. 2002
  3. ncbi Comparison of hexaminolevulinate based flexible and rigid fluorescence cystoscopy with rigid white light cystoscopy in bladder cancer: results of a prospective Phase II study
    J Alfred Witjes
    Department of Urology, University Medical Centre, St Radboud, Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 47:319-22. 2005
  4. ncbi Reduced folate carrier polymorphism (80A-->G) and neural tube defects
    Patrizia De Marco
    Laboratorio del Servizio di Neurochirugia, Istituto G Gaslini, Genova, Italy
    Eur J Hum Genet 11:245-52. 2003
  5. ncbi Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA, USA
    Am J Epidemiol 158:747-52. 2003
  6. ncbi Reduced folate carrier gene is a risk factor for neural tube defects in a Chinese population
    Lijun Pei
    Institute of Reproductive and Child Health, Peking University Health Science Center, No 38 Xueyuan Road, Haidian District, Beijing 100083, China
    Birth Defects Res A Clin Mol Teratol 73:430-3. 2005
  7. ncbi No association between common polymorphisms in genes of folate and homocysteine metabolism and the risk of Down's syndrome among French mothers
    Abalo Chango
    INSERM U 724, Laboratory of Nutritional Genomics, ISAB Agrohealth, 60026 Beauvais, France
    Br J Nutr 94:166-9. 2005
  8. ncbi Folate gene polymorphisms and the risk of Down syndrome pregnancies in young Italian women
    Fabio Coppede
    Department of Human and Environmental Sciences, University of Pisa, Pisa, Italy
    Am J Med Genet A 140:1083-91. 2006
  9. ncbi Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring
    Iris Scala
    Department of Pediatrics, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Genet Med 8:409-16. 2006
  10. ncbi Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil
    J M Biselli
    Unidade de Pesquisa em Genética e Biologia Molecular, Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brasil
    Genet Mol Res 7:33-42. 2008

Research Grants

  1. Larry H Matherly; Fiscal Year: 2015
  2. SHERMAINE KIMBERLY MITCHELL; Fiscal Year: 2014
  3. Larry H Matherly; Fiscal Year: 2015
  4. Alan E Tomkinson; Fiscal Year: 2016
  5. PCNA clamp mechanisms in DNA replication and repair
    Manju M Hingorani; Fiscal Year: 2010
  6. Dorothy A Erie; Fiscal Year: 2016
  7. Arthur J Lustig; Fiscal Year: 2014
  8. JENNIFER LYNN STRIPAY; Fiscal Year: 2015
  9. Factors Regulating NE Transporter Localization in PFC
    Susan R Sesack; Fiscal Year: 2011
  10. Regulation of Adult Neurogenesis by Methamphetamine
    Chitra D Mandyam; Fiscal Year: 2012

Detail Information

Publications221 found, 100 shown here

  1. ncbi Predictors of successful radiofrequency catheter ablation of sinoatrial tachycardia
    M Y Ivanov
    Clinical Electrophysiology Laboratory, Cardiosurgery Clinic, Emergency Hospital, Cheliabinsk, Russia
    Pacing Clin Electrophysiol 21:311-5. 1998
    Predictors of successful elimination of sinoatrial tachycardia (SAT) using radiofrequency current (RFC) were investigated in this report...
  2. ncbi Replication factor C from the hyperthermophilic archaeon Pyrococcus abyssi does not need ATP hydrolysis for clamp-loading and contains a functionally conserved RFC PCNA-binding domain
    Ghislaine Henneke
    IFREMER, Laboratoire de Microbiologie et Biotechnologie des Extrêmophiles, DRV VP, BP 70, F 29280 Plouzane, France
    J Mol Biol 323:795-810. 2002
    ..Only two proteins homologous to subunits of eukaryotic replication factor C (RFC) have been detected in Pyrococcus abyssi (Pab). The genes encoding these two proteins are arranged in tandem...
  3. ncbi Comparison of hexaminolevulinate based flexible and rigid fluorescence cystoscopy with rigid white light cystoscopy in bladder cancer: results of a prospective Phase II study
    J Alfred Witjes
    Department of Urology, University Medical Centre, St Radboud, Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 47:319-22. 2005
    Several studies have shown that rigid fluorescence cystoscopy (RFC) with hexaminolevulinate (HAL) is superior to standard rigid white light (RWLC) cystoscopy in diagnosing bladder tumours, with a clinically relevant impact on the patient'..
  4. ncbi Reduced folate carrier polymorphism (80A-->G) and neural tube defects
    Patrizia De Marco
    Laboratorio del Servizio di Neurochirugia, Istituto G Gaslini, Genova, Italy
    Eur J Hum Genet 11:245-52. 2003
    Transport of folates in mammalian cells occurs by a carrier-mediated mechanism. The human folate carrier (RFC-1) gene has been isolated and characterized...
  5. ncbi Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA, USA
    Am J Epidemiol 158:747-52. 2003
    ..The authors focused on a gene involved in folate transport-reduced folate carrier-1 gene (RFC1)...
  6. ncbi Reduced folate carrier gene is a risk factor for neural tube defects in a Chinese population
    Lijun Pei
    Institute of Reproductive and Child Health, Peking University Health Science Center, No 38 Xueyuan Road, Haidian District, Beijing 100083, China
    Birth Defects Res A Clin Mol Teratol 73:430-3. 2005
    ..At present, the mechanism by which folic acid exerts its beneficial effect remains unknown. Folate transporter genes, including the reduced folate carrier gene (RFC1), have been proposed as NTD risk factors.
  7. ncbi No association between common polymorphisms in genes of folate and homocysteine metabolism and the risk of Down's syndrome among French mothers
    Abalo Chango
    INSERM U 724, Laboratory of Nutritional Genomics, ISAB Agrohealth, 60026 Beauvais, France
    Br J Nutr 94:166-9. 2005
    ..synthase (MTR) 2756A > G, the cystathionine beta-synthase (CBS) 844Ins68 and the reduced folate carrier (RFC-1) 80G > A polymorphisms, contribute to the risk of trisomy 21...
  8. ncbi Folate gene polymorphisms and the risk of Down syndrome pregnancies in young Italian women
    Fabio Coppede
    Department of Human and Environmental Sciences, University of Pisa, Pisa, Italy
    Am J Med Genet A 140:1083-91. 2006
    ..The 80G>A polymorphism of the reduced folate carrier gene (RFC-1) has been recently demonstrated to affect plasma folate and homocysteine levels, alone or in combination with the ..
  9. ncbi Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring
    Iris Scala
    Department of Pediatrics, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Genet Med 8:409-16. 2006
    ..Gene-gene/allele-allele interactions, haplotype analysis and the association with age at conception were also evaluated...
  10. ncbi Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil
    J M Biselli
    Unidade de Pesquisa em Genética e Biologia Molecular, Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brasil
    Genet Mol Res 7:33-42. 2008
    ..reductase (MTHFR) gene, A2756G in methionine synthase reductase (MTR) gene and A80G in reduced folate carrier 1 (RFC1) gene, and plasma homocysteine (Hcy), on the maternal risk for Down syndrome (DS)...
  11. ncbi A80G polymorphism of reduced folate carrier 1 (RFC1) and C776G polymorphism of transcobalamin 2 (TC2) genes in Down's syndrome etiology
    Joice Matos Biselli
    Genetics and Molecular Biology Research Unit, Department of Molecular Biology, Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose do Rio Preto, Sao Paulo, Brazil
    Sao Paulo Med J 126:329-32. 2008
    ..This study therefore had the objective of investigating the A80G polymorphism of the reduced folate carrier 1 (RFC1) gene and the C776G polymorphism of the transcobalamin 2 (TC2) gene as maternal risk factors for DS among Brazilian ..
  12. pmc Investigation of CBS, MTR, RFC-1 and TC polymorphisms as maternal risk factors for Down syndrome
    N Fintelman-Rodrigues
    Departamento de Genetica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    Dis Markers 26:155-61. 2009
    ..We compared the frequency of CBS 844ins68, MTR 2756A>G, RFC-1 80G&gt A and TC 776C>G polymorphisms among 114 case mothers and 110 matched controls, in order to observe ..
  13. ncbi [Folate gene polymorphism and the risk of Down syndrome pregnancies in young Chinese women]
    Ya Ping Liao
    Department of Cell Biology, Bengbu Medical College, Bengbu 233030, China
    Yi Chuan 32:461-6. 2010
    ..in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), reduced folate carrier1 (RFC-1), methionine synthase (MTR) involved in folate metabolism and the risk of offsprings of young Chinese women with ..
  14. pmc Maternal gene polymorphisms involved in folate metabolism as risk factors for Down syndrome offspring in Southern Brazil
    Ana Paula Carneiro Brandalize
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
    Dis Markers 29:95-101. 2010
    ..of maternal polymorphisms, as well as their risk genotypes combinations of MTR A2756G, MTRR A66G, CBS 844ins68, and RFC A80G, involved in folate/homocysteine metabolism, as possible risk factors for Down syndrome (DS) in Southern ..
  15. ncbi Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida
    Gary M Shaw
    March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, California 94606, USA
    Am J Med Genet 108:1-6. 2002
    ..We focused our studies on a candidate gene that is involved in folate transport, the reduced folate carrier 1 (RFC1)...
  16. ncbi Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial defects and congenital heart defects in China
    Lijun Pei
    Institute of Reproductive and Child Health, Peking University, China
    Ann Epidemiol 16:352-6. 2006
    ..to investigate whether the risks of congenital heart defects (CHD) and orofacial defects were influenced by a polymorphism of the offspring's RFC1 or by an interaction between the RFC1 gene and maternal periconceptional use of folic acid.
  17. ncbi A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function
    R Zhao
    Departments of Medicine and Molecular Pharmacology, and the Albert Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 273:19065-71. 1998
    In an ongoing study of structure-function relationships of the murine reduced folate carrier 1 (RFC1), a glutamate to lysine mutation at amino acid 45 was identified in a methotrexate (MTX)-resistant L1210 clonal variant in which MTX and ..
  18. doi Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats
    Tomoharu Yokooji
    Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hiroshima International University, Hiroshima, Japan
    J Pharm Pharmacol 61:911-8. 2009
    ..a substrate for proton-coupled folate transporter/haem carrier protein 1 (PCFT/HCP1) and reduced folate carrier 1 (RFC1)...
  19. pmc Association of thymidylate synthase gene polymorphisms with stavudine triphosphate intracellular levels and lipodystrophy
    Pere Domingo
    Infectious Diseases Unit, Hospital de Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Antimicrob Agents Chemother 55:1428-35. 2011
    ..TS), methylenetetrahydrofolate reductase (MTHFR), dihydrofolate reductase (DHFR), reduced folate carrier 1 (RFC1; SLC19A1), and cyclin D1 (CCND1) genes were determined by direct sequencing using an ABI Prism 3100 genetic ..
  20. doi Health assessment of phosgene: approaches for derivation of reference concentration
    Jeffrey S Gift
    National Center for Environmental Assessment, Office of Research and Development, United States Environmental Protection Agency, 1200 Pennsylvania Avenue, Washington, DC 20460, USA
    Regul Toxicol Pharmacol 51:98-107. 2008
    This paper describes the derivation of the chronic reference concentration (RfC) for human inhalation of phosgene that was recently added to the Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) data base (..
  21. ncbi The gene cluster directing O-antigen biosynthesis in Yersinia enterocolitica serotype 0:8: identification of the genes for mannose and galactose biosynthesis and the gene for the O-antigen polymerase
    L Zhang
    Department of Medical Microbiology, University of Turku, Finland
    Microbiology 142:277-88. 1996
    ..Deletion analysis generated a derivative that expressed semi-rough LPS, a phenotype typical of an rfc mutant lacking the O-antigen polymerase...
  22. ncbi Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase
    A L Jackman
    The Cancer Research Campaign Centre for Cancer Therapeutics at the Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG United Kingdom
    Clin Cancer Res 3:911-21. 1997
    ..synthase (TS) that are transported into cells via a saturable, carrier-mediated system (reduced folate carrier, or RFC) but are not substrates for folylpolyglutamate synthetase...
  23. ncbi [Primary study on establishment of namalwa 12/MTX resistant cell strain and its mechanism]
    Jing Chen
    Shanghai Xinhua Hospital, Shanghai Children s Medical Center, Shanghai Second Medical University, Shanghai 200092, P R China
    Ai Zheng 21:1335-40. 2002
    ..However, there was few report about its drug resistance mechanism in lymphoma. This study was designed to establish Burkitt's lymphoma methotrexate resistant cell strain--Namlwa 12/MTX and study its resistant mechanism...
  24. ncbi Colorectal carcinomas with microsatellite instability display increased thymidylate synthase gene expression levels
    Elisabeth Odin
    Department of General Surgery, Goteborg University, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Clin Colorectal Cancer 6:720-7. 2007
    ..The gene expression levels of thymidylate synthase (TS), reduced folate carrier (RFC-1), folylpolyglutamate synthase (FPGS), and methylenetetrahydrofolate reductase (MTHFR) in mucosa and tumor were ..
  25. ncbi Effects from environmental Mn exposures: a review of the evidence from non-occupational exposure studies
    H K Hudnell
    U S Environmental Protection Agency, Neurotoxicology Division, Research Triangle Park, NC 27711, USA
    Neurotoxicology 20:379-97. 1999
    ..The stages are: 1) sources, 2) applied dose, 3) absorbed dose, 4) target-site dose, 5) toxic event, 6) measurable change, and 7) health outcome...
  26. ncbi Estimation of interindividual pharmacokinetic variability factor for inhaled volatile organic chemicals using a probability-bounds approach
    Andy Nong
    Groupe deRecherche Interdisciplinaire en Santé and Groupe de Recherche en Toxicologie Humaine TOXHUM, Faculte de Medecine, Universite de Montreal, Montreal, Que, Canada
    Regul Toxicol Pharmacol 48:93-101. 2007
    ..Since the RfC derivation considers continuous lifetime human exposure to VOCs in the environment, algorithms to compute steady-..
  27. ncbi Modifications of the immune response induced by Histoplasma capsulatum products
    B H Ruiz
    Instituto de Investigaciones Biomedicas, Facultad de Medicina, Universidad Nacional Autonoma de Mexico
    Mycopathologia 109:1-9. 1990
    ..Variation of the response with time was determined by counting the number of rosette forming cells (RFC) to SRBC every two days for a total of 21 days...
  28. pmc Distribution of the rol gene encoding the regulator of lipopolysaccharide O-chain length in Escherichia coli and its influence on the expression of group I capsular K antigens
    C Dodgson
    Department of Microbiology, University of Guelph, Guelph, Ontario, Canada
    J Bacteriol 178:1895-902. 1996
    ..Rol interacts with one or more components of Rfc-dependent O-antigen biosynthetic complexes to regulate the chain length of lipopolysaccharide O antigens...
  29. pmc Complete in vitro reconstitution of adeno-associated virus DNA replication requires the minichromosome maintenance complex proteins
    Kevin Nash
    Department of Molecular Genetics and Microbiology, University of Florida, 1376 Mowry Rd, Gainesville, FL 32610, USA
    J Virol 82:1458-64. 2008
    ..Fractionation of these crude extracts identified replication factor C (RFC), proliferating cell nuclear antigen (PCNA), and polymerase delta as cellular enzymes that were essential for AAV ..
  30. pmc Purification of host cell enzymes involved in adeno-associated virus DNA replication
    Kevin Nash
    Department of Molecular Genetics and Microbiology, University of Florida, 1376 Mowry Rd, Gainesville, FL 32610, USA
    J Virol 81:5777-87. 2007
    ..Fractions that contained replication factor C (RFC) and proliferating cell nuclear antigen (PCNA) were found to be essential for reconstituting AAV DNA replication...
  31. doi Endotoxin exposure and inflammation markers among agricultural workers in Colorado and Nebraska
    James B Burch
    Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program, and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
    J Toxicol Environ Health A 73:5-22. 2010
    ..over one work shift to quantify inhalable dust (Institute of Medicine samplers), endotoxin (recombinant factor C [rFC] assay), and 3-OHFA (gas chromatography/mass spectrometry)...
  32. ncbi Molecular cloning and characterization of the rfc gene of Pseudomonas aeruginosa (serotype O5)
    T R De Kievit
    Canadian Bacterial Disease Network, University of Guelph, Ontario, Canada
    Mol Microbiol 16:565-74. 1995
    ..mutants, AK14O1 and rd7513, resulted in O-antigen expression, indicating that pFV100 may contain an O-polymerase (rfc) gene. pFV.TK6, a subclone of pFV100 that contains a 5...
  33. ncbi Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5' end heterogeneity
    B Tolner
    Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gene 211:331-41. 1998
    The organization and structure of the human RFC-1 gene encoding a folate transporter were determined. The RFC-1 gene spans 22...
  34. ncbi Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells
    Rongbao Zhao
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Cell Physiol 282:C1512-7. 2002
    Although the reduced folate carrier RFC1 and the thiamine transporters THTR-1 and THTR-2 share approximately 40% of their identity in protein sequence, RFC1 does not transport thiamine and THTR-1 and THTR-2 do not transport folates...
  35. ncbi Physical interaction between proliferating cell nuclear antigen and replication factor C from Pyrococcus furiosus
    Shigeki Matsumiya
    Department of Structural Biology, Biomolecular Engineering Research Institute, 6 2 3, Furuedai, Suita, Osaka 565 0874, Japan
    Genes Cells 7:911-22. 2002
    ..This allowed us to examine its interaction with the loading factor at the atomic level...
  36. ncbi Large tip electrodes for successful elimination of atrial flutter resistant to conventional catheter ablation
    Rodolfo Ventura
    Department of Cardiology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Interv Card Electrophysiol 8:149-54. 2003
    The most widely accepted criterion for successful radiofrequency catheter (RFC) ablation of typical atrial flutter is the development of bi-directional isthmus block...
  37. doi Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs
    John J McGuire
    Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263, United States
    Biochem Pharmacol 77:1161-72. 2009
    ..5.1.3) as their locus of action and transport by the reduced folate carrier (RFC; SLC19A1), but their lack of metabolism by known pathways of antifolate (e.g., methotrexate (MTX)) metabolism...
  38. pmc Analysis of the role of PCNA-DNA contacts during clamp loading
    Randall McNally
    Department of Molecular and Cell Biology, Department of Chemistry, California Institute for Quantitative Biosciences QB3, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    BMC Struct Biol 10:3. 2010
    ..In an ATP-dependent reaction, clamp loader complexes, such as the Replication Factor-C (RFC) complex in eukaryotes, open the clamp and load it around primer-template DNA.
  39. ncbi Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples
    Rui Yang
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 9:837-44. 2003
    ..Its effectiveness may be limited by intrinsic and acquired resistance. Decreased reduced folate carrier (RFC) expression has been shown in approximately half of osteosarcomas at diagnosis...
  40. doi Molecular cloning and tissue distribution of reduced folate carrier and effect of dietary folate supplementation on the expression of reduced folate carrier in laying hens
    M Jing
    Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, Canada
    Poult Sci 88:1939-47. 2009
    The reduced folate carrier (RFC) has been postulated to be a major entity for folate transport activity in humans and other mammals. However, there are limited reports of the importance of RFC in an avian system...
  41. ncbi Application of a physiologically based pharmacokinetic model for reference dose and reference concentration estimation for acetone
    P Robinan Gentry
    ENVIRON International Corporation, Ruston, Louisiana 71270, USA
    J Toxicol Environ Health A 66:2209-25. 2003
    ..in subchronic and developmental toxicity studies to estimate an RfD and an inhalation reference concentration (RfC) for acetone. Specifically, this approach examined the subchronic study by Dietz et al...
  42. pmc Assessing dangerous climate change through an update of the Intergovernmental Panel on Climate Change (IPCC) "reasons for concern"
    Joel B Smith
    Stratus Consulting, Inc, Boulder, CO 80306 4059, USA
    Proc Natl Acad Sci U S A 106:4133-7. 2009
    ..Relationships between various impacts reflected in each RFC and increases in global mean temperature (GMT) were portrayed in what has come to be called the "burning embers ..
  43. pmc Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process
    Ceslovas Venclovas
    Computational and Systems Biology Division, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, California 94550, USA
    Protein Sci 11:2403-16. 2002
    ..with known structural, biochemical, and genetic data, we propose detailed models of how two of the RFC subunits, RFC1 and RFC3, interact with the C-terminal regions of PCNA...
  44. pmc A humanized mouse model for the reduced folate carrier
    David Patterson
    Eleanor Roosevelt Institute, Department of Biological Sciences, University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Mol Genet Metab 93:95-103. 2008
    The ubiquitously expressed reduced folate carrier (RFC) or SLC19A1 is recognized to be an essential transport system for folates in mammalian cells and tissues...
  45. pmc Identification of the O antigen polymerase (rfc) gene in Escherichia coli O4 by insertional mutagenesis using a nonpolar chloramphenicol resistance cassette
    S Lukomski
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Bacteriol 178:240-7. 1996
    ..O antigen polymerase, which is encoded by the rfc gene, is a potential membrane protein and therefore should be hydrophobic...
  46. pmc Biochemical analysis of replication factor C from the hyperthermophilic archaeon Pyrococcus furiosus
    I K Cann
    Department of Molecular Biology, Biomolecular Engineering Research Institute, 6 2 3 Furuedai, Suita, Osaka 565 0874, Japan
    J Bacteriol 183:2614-23. 2001
    Replication factor C (RFC) and proliferating cell nuclear antigen (PCNA) are accessory proteins essential for processive DNA synthesis in the domain Eucarya...
  47. ncbi Three-dimensional electron microscopy of the clamp loader small subunit from Pyrococcus furiosus
    K Mayanagi
    Biomolecular Engineering Research Institute BERI, 6 2 3 Furuedai, Suita City, 565 0874, Japan
    J Struct Biol 134:35-45. 2001
    An archaeal clamp loader, replication factor C (RFC), consists of two proteins, the small subunit (RFCS) and large subunit (RFCL), whose sequences are both highly homologous to those of the eukaryotic RFC components...
  48. ncbi Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability
    Pamela Kanellis
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Curr Biol 13:1583-95. 2003
    ..Genome instability is a hallmark of cancer and plays a critical role in generating the myriad of phenotypes selected for during tumor progression. However, the mechanisms that prevent genome rearrangements remain poorly understood...
  49. ncbi Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients
    Yvonne Wettergren
    Department of General Surgery, Sahlgrenska University Hospital Ostra, Goteborg University, S 416 85 Goteborg, Sweden
    Cancer Detect Prev 29:348-55. 2005
    ..The purpose of this study was to analyze if the folate level and the gene expression levels of reduced folate carrier (RFC-1) and folylpolyglutamate synthase (FPGS) had impact on the expression of DCC splice variants.
  50. ncbi Identification of the critical region in replication factor C from Pyrococcus furiosus for the stable complex formation with proliferating cell nuclear antigen and DNA
    Hirokazu Nishida
    Department of Structural Biology, Biomolecular Engineering Research Institute, Suita, Osaka, Japan
    Genes Genet Syst 80:83-93. 2005
    Replication factor C (RFC) and proliferating cell nuclear antigen (PCNA) are accessory proteins essential for processive DNA synthesis...
  51. ncbi Interplay between primase and replication factor C in the hyperthermophilic archaeon Sulfolobus solfataricus
    Kangyun Wu
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
    Mol Microbiol 63:826-37. 2007
    ..Here we show that the small subunit of the clamp loader replication factor C (RFC) of S...
  52. ncbi Reduced folate carrier 1 (RFC1) is associated with cleft of the lip only
    A R Vieira
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    Braz J Med Biol Res 41:689-93. 2008
    ..Therefore, we tested if markers in MTHFR (5,10-methylenetetrahydrofolate reductase) and RFC1 (reduced folate carrier 1) were associated with oral clefts, depending on the maternal origin defined by the ..
  53. ncbi Measuring residual functional capacity in chronic low back pain patients based on the Dictionary of Occupational Titles
    D A Fishbain
    Department of Psychiatry, University of Miami, School of Medicine Comprehensive Pain and Rehabilitation Center, South Shore Hospital, Florida
    Spine (Phila Pa 1976) 19:872-80. 1994
    ..OBJECTIVES. Such a battery can be used to measure residual functional capacity (RFC) in chronic pain patients (CPP) and results can be matched against the demand minimum functional capacities (DMFC) ..
  54. ncbi Organization, structure and alternate splicing of the murine RFC-1 gene encoding a folate transporter
    B Tolner
    Laboratory for Molecular Therapeutics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Gene 189:1-7. 1997
    The structural organization of the murine RFC-1 gene encoding a folate transporter has been determined...
  55. ncbi The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta
    A Rosowsky
    Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 44 Binney Street, Boston, MA, USA
    Pharmacol Ther 85:191-205. 2000
    ..dihydrofolate reductase (DHFR) inhibitor and is efficiently taken up into cells via the reduced folate carrier (RFC)...
  56. pmc Biochemical characterisation of the clamp/clamp loader proteins from the euryarchaeon Archaeoglobus fulgidus
    Anja Seybert
    Molecular Enzymology Laboratory, London Research Institute, Clare Hall Laboratories, Cancer Research UK
    Nucleic Acids Res 30:4329-38. 2002
    ..processivity using ring-shaped DNA sliding clamps that are loaded onto DNA by clamp loaders [replication factor C (RFC) in eukaryotes]...
  57. ncbi Placental folate transport during pregnancy
    Satoru Yasuda
    Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmascience, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 72:2277-84. 2008
    ..We found that folate receptor alpha (FRalpha) and reduced folate carrier (RFC) localized on the apical side of human placental villi...
  58. ncbi 5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism
    John J McGuire
    Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Res 66:3836-44. 2006
    ..transporter with the widest tissue distribution and greatest activity is the reduced folate carrier (RFC). There is little evidence that RFC-mediated influx is posttranscriptionally regulated...
  59. ncbi Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity
    Ilan Ifergan
    Department of Biology, The Technion, Haifa, Israel
    Cancer 98:1958-66. 2003
    ..Although MTX uptake proceeds primarily through the reduced folate carrier (RFC) protein and efflux occurs via multidrug resistance protein 1 (MRP1), RFC protein expression in osteosarcoma ..
  60. ncbi Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis
    Gerrit Jansen
    Department of Rheumatology, Vrije Universiteit Medisch Centrum, Amsterdam, The Netherlands
    Arthritis Rheum 50:2130-9. 2004
    To investigate whether interactions of sulfasalazine (SSZ) with reduced folate carrier (RFC), the dominant cell membrane transporter for natural folates and methotrexate (MTX), may limit the efficacy of combination therapy with MTX and ..
  61. ncbi Pattern of isthmus conduction recovery using open cooled and solid large-tip catheters for radiofrequency ablation of typical atrial flutter
    Rodolfo Ventura
    Department of Cardiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Cardiovasc Electrophysiol 15:1126-30. 2004
    Open cooled-tip and solid 8-mm-tip catheters have demonstrated safety and effectiveness for radiofrequency current (RFC) ablation of typical atrial flutter (AFL)...
  62. doi Renal frame count and renal blush grade: quantitative measures that predict the success of renal stenting in hypertensive patients with renal artery stenosis
    Ehtisham Mahmud
    Division of Cardiovascular Medicine, School of Medicine, University of California, San Diego, California 92103 8784, USA
    JACC Cardiovasc Interv 1:286-92. 2008
    ..This study sought to identify angiographic parameters of favorable clinical response to renal artery stenting...
  63. pmc Fission yeast Rad17 associates with chromatin in response to aberrant genomic structures
    M Kai
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Mol Cell Biol 21:3289-301. 2001
    ..Rad17 is able to complex in vivo with an Rfc small subunit, Rfc2, but not with Rfc1. Furthermore, cells with rfc1Delta are checkpoint proficient, suggesting that Rfc1 does not have a role in ..
  64. pmc Purification and characterization of human DNA damage checkpoint Rad complexes
    L A Lindsey-Boltz
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 98:11236-41. 2001
    ..Rad proteins, we purified a heteropentameric complex composed of hRad17-RFCp36-RFCp37-RFCp38-RFCp40 (hRad17-RFC) and a heterotrimeric complex composed of hRad9-hHus1-hRad1 (checkpoint 9-1-1 complex)...
  65. pmc Extensive variation in the O-antigen gene cluster within one Salmonella enterica serogroup reveals an unexpected complex history
    Lei Wang
    Department of Microbiology, The University of Sydney, Sydney, New South Wales 2006, Australia
    J Bacteriol 184:1669-77. 2002
    ..Two of the forms lacking a functional wzy(alpha(1-6)) gene have the wzy(alpha(1-2)) gene first described for strain LT2 as rfc, whereas for the third the wzy gene has not been located.
  66. pmc Restoration of high-level transport activity by human reduced folate carrier/ThTr1 thiamine transporter chimaeras: role of the transmembrane domain 6/7 linker region in reduced folate carrier function
    Xiang Y Liu
    Cancer Biology Graduate Program, Karmanos Cancer Institute, Wayne State University School of Medicine, 110 E Warren Avenue, Detroit, MI 48201, USA
    Biochem J 369:31-7. 2003
    The reduced folate carrier (RFC; SLC19A1) is closely related to the thiamine transporter, SLC19A2 (ThTr1)...
  67. ncbi Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporters and reduced folate carrier
    Yoshitane Nozaki
    Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku Tokyo, 13 0033 Japan
    J Pharmacol Exp Ther 309:226-34. 2004
    ..MTX is recognized by reduced folate carrier (RFC-1) and rat organic anion transporters (rOat1 and rOat3) as a substrate...
  68. pmc Identification of protein complexes required for efficient sister chromatid cohesion
    Melanie L Mayer
    Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    Mol Biol Cell 15:1736-45. 2004
    Ctf8p is a component of Ctf18-RFC, an alternative replication factor C-like complex required for efficient sister chromatid cohesion in Saccharomyces cerevisiae...
  69. ncbi Review and analysis of inhalation dosimetry methods for application to children's risk assessment
    Gary L Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
    J Toxicol Environ Health A 68:573-615. 2005
    ..S. Environmental Protection Agency (U.S. EPA) 1994 reference concentration (RfC) methodology and the ICRP 1994 inhalation dosimetry model...
  70. ncbi The reduced folate carrier gene is a novel selectable marker for recombinant protein overexpression
    Lilah Rothem
    Department of Biology, Technion Israel Institute of Technology, Haifa 32000, Israel
    Mol Pharmacol 68:616-24. 2005
    ..and are therefore folate auxotrophs that take up folate vitamins primarily via the reduced folate carrier (RFC)...
  71. pmc Evolutionary clues to eukaryotic DNA clamp-loading mechanisms: analysis of the functional constraints imposed on replication factor C AAA+ ATPases
    Andrew F Neuwald
    Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724, USA
    Nucleic Acids Res 33:3614-28. 2005
    ..In eukaryotes, sliding clamps are loaded onto DNA by the replication factor C (RFC) complex, which consists of five distinct subunits (A-E), each of which contains an AAA+ module composed of a RecA-..
  72. ncbi ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication
    Jie Jessie Lin
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 282:30357-62. 2007
    ..re-replication has been detected is the ATR kinase and the Rad9-Rad1-Hus1 (9-1-1) clamp complex together with Rad17-RFC clamp loader. ATM kinase and the Mre11-Rad50-Nbs1 complex do not appear to play significant roles in the checkpoint...
  73. ncbi Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I
    Aleem Gangjee
    Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    Anticancer Agents Med Chem 7:524-42. 2007
    ..12)}, can passively diffuse into cells and hence do not have to depend on FPGS or the reduced folate carrier (RFC)...
  74. pmc The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis
    Ilan Ifergan
    The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion Israel Institute of Technology, Haifa, Israel
    J Biol Chem 283:20687-95. 2008
    The reduced folate carrier (RFC), a bidirectional anion transporter, is the major uptake route of reduced folates essential for a spectrum of biochemical reactions and thus cellular proliferation...
  75. pmc Functional connectivity MR imaging reveals cortical functional connectivity in the developing brain
    W Lin
    Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    AJNR Am J Neuroradiol 29:1883-9. 2008
    ..This study aimed to determine the temporal and spatial patterns of rfc in healthy pediatric subjects between 2 weeks and 2 years of age.
  76. pmc Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice
    Eiram Elahi
    Colorectal Cancer Genetics, Institute for Cell and Molecular Sciences, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    PLoS ONE 4:e4388. 2009
    ..that are involved in spindle checkpoint and chromosomal stability (Bub1b, Casc5, and Bub1), DNA repair (Recc1 and Prkdc) or inflammation (Duox2, Itgb2l and Cxcl5)...
  77. pmc Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target
    Jessica McLellan
    Department of Medical Genetics, The University of British Columbia, Vancouver, BC, Canada
    Mol Biol Cell 20:5306-13. 2009
    ..SL interactions between members of the cohesin complex and CTF4, RAD27, and components of the alternative RFC(CTF18) complex. The genetic interactions tested are highly conserved between S. cerevisiae and C...
  78. pmc Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA
    Oren Parnas
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv, Israel
    EMBO J 29:2611-22. 2010
    Replication-factor C (RFC) is a protein complex that loads the processivity clamp PCNA onto DNA. Elg1 is a conserved protein with homology to the largest subunit of RFC, but its function remained enigmatic...
  79. doi Regulatory mechanisms of intestinal folate uptake in a rat model of folate oversupplementation
    Som Dev
    Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
    Br J Nutr 105:827-35. 2011
    ..protein levels of major folate transporters, proton-coupled folate transporter (PCFT) and reduced folate carrier (RFC), without altering their mRNA levels...
  80. doi Reduced folate carrier and folylpolyglutamate synthetase, but not thymidylate synthase predict survival in pemetrexed-treated patients suffering from malignant pleural mesothelioma
    Fabian Mairinger
    Department of Pathology and Neuropathology, University Hospital Essen, University of Duisberg Essen, Essen, Germany
    J Thorac Oncol 8:644-53. 2013
    ..of pemetrexed occurs by folylpolyglutamate synthetase (FPGS), intracellular transport by reduced folate carrier (RFC)...
  81. doi A prospective randomized single-center study on the risk of asymptomatic cerebral lesions comparing irrigated radiofrequency current ablation with the cryoballoon and the laser balloon
    Boris Schmidt
    Cardioangiologisches Centrum Bethanien, Frankfurt M, Germany
    J Cardiovasc Electrophysiol 24:869-74. 2013
    ..We sought to compare the ACL incidence between 3 contemporary technologies: (1) irrigated radiofrequency current (RFC), (2) the single big cryoballoon (CB), and (3) the endoscopic laser-balloon (LB) in a prospective randomized pilot ..
  82. doi The mechanism of ORFH79 suppression with the artificial restorer fertility gene Mt-GRP162
    Jun Hu
    State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan, China
    New Phytol 199:52-8. 2013
    The restoration fertility complex (RFC) was previously identified in Honglian (HL)-cytoplasmic male sterility (CMS) rice (Oryza sativa), and glycine-rich protein 162 (GRP162) is responsible for binding to the CMS-associated transcript ..
  83. doi Association of SNPs in genes involved in folate metabolism with the risk of congenital heart disease
    Benjing Wang
    Center for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu Province 215002, China
    J Matern Fetal Neonatal Med 26:1768-77. 2013
    ..To investigate the association of 12 single nucleotide polymorphisms (SNPs) in folate metabolic genes with congenital heart disease (CHD)...
  84. ncbi [Personalized drug therapy-directed clinical pharmacology research based on genetic polymorphisms and pharmacokinetics analysis]
    Hideki Hayashi
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka
    Yakugaku Zasshi 133:1079-85. 2013
    ..We found that the frequency of the RFC1 80A allele was higher in RA patients treated with MTX alone compared with patients who received biological disease-..
  85. doi A random forest classifier for lymph diseases
    Ahmad Taher Azar
    Faculty of Computers and Information, Benha University, Egypt Electronic address
    Comput Methods Programs Biomed 113:465-73. 2014
    ..In this paper, a random forest classifier (RFC) approach is proposed to diagnose lymph diseases...
  86. doi Modulation of intestinal folate absorption by erythropoietin in vitro
    Junkai Yan
    State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Handan Road 220, Shanghai, China
    Mol Pharm 11:358-66. 2014
    ..in a dose-dependent manner, which was companied with the significant up-regulation of reduced folate carrier (RFC) and apical proton coupled folate transporter (PCFT)...
  87. doi Association between reduced folate carrier G80A polymorphism and methotrexate toxicity in childhood acute lymphoblastic leukemia: a meta-analysis
    Hai Rong He
    Department of Pharmacy, the First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an, China
    Leuk Lymphoma 55:2793-800. 2014
    ..lymphoblastic leukemia (ALL), and enters the cell via active transport mediated by the reduced folate carrier (RFC1)...
  88. doi Folate metabolism gene polymorphisms and risk for down syndrome offspring in Turkish women
    Ozlem Izci Ay
    1 Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey
    Genet Test Mol Biomarkers 19:191-7. 2015
    ..A1298C (rs1801131), methionine synthase reductase (MTRR) A66G (rs1801394), methylenetetrahydrofolate dehydrogenase (MTHFD1) G1958A (rs2236225), reduced folate carrier (RFC1) A80G (rs1051266), and cystathionine β-synthase (CBS) 844ins68.
  89. doi Assessing human variability in kinetics for exposures to multiple environmental chemicals: a physiologically based pharmacokinetic modeling case study with dichloromethane, benzene, toluene, ethylbenzene, and m-xylene
    Mathieu Valcke
    a Institut national de santé publique du Québec, Montreal, Quebec, Canada
    J Toxicol Environ Health A 78:409-31. 2015
    ..AD), neonates (NEO), toddlers (TODD), and pregnant women (PW) were used to simulate inhalation exposure to "low" (RfC-like) or "high" (AEGL-like) air concentrations of benzene (Bz) or dichloromethane (DCM), along with various levels ..
  90. doi MCM9 Is Required for Mammalian DNA Mismatch Repair
    Sabine Traver
    Laboratory of DNA Replication and Genome Dynamics, Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France
    Mol Cell 59:831-9. 2015
    ..recombination, forms a complex with MMR initiation proteins (MSH2, MSH3, MLH1, PMS1, and the clamp loader RFC) and is essential for MMR. Mcm9-/- cells display microsatellite instability and MMR deficiency...
  91. pmc ShRNA-mediated silencing of the RFC3 gene suppress ovarian tumor cells proliferation
    Huimin Shen
    The First Affiliated Hospital, Sun Yat Sen University Guangzhou, China
    Int J Clin Exp Pathol 8:8968-75. 2015
    Ovarian carcinoma is one of the most common and lethal malignancies in the world. Replication factor C (RFC) plays an important role in DNA replication, DNA damage repair, and checkpoint control during cell cycle progression in all ..
  92. pmc Quantitative Imaging Assessment of an Alternative Approach to Surgical Mitral Valve Leaflet Resection: An Acute Porcine Study
    Steven M Boronyak
    Department of Biomedical Engineering, Vanderbilt University, Room 9445D MRB IV Langford, 2213 Garland Avenue, Nashville, TN, 37232 0493, USA
    Ann Biomed Eng 44:2240-50. 2016
    This study reports the initial in vivo use of a combined radiofrequency ablation and cryo-anchoring (RFC) catheter as an alternative to surgical mitral valve (MV) leaflet resection...
  93. pmc Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase
    Siobhan M Deis
    Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States
    Biochemistry 55:4574-82. 2016
    ..have toxic side effects resulting, in part, from nonspecific cellular transport by the reduced folate carrier (RFC), a ubiquitously expressed facilitative transporter...
  94. pmc Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC
    Fredrick J Rosario
    Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
    Sci Rep 6:31705. 2016
    ..mTORC1 or mTORC2 silencing markedly decreased the plasma membrane expression of FR-α and RFC transporter isoforms without affecting global protein expression...
  95. ncbi Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation
    Nicole Vo
    Department of Applied Biology, Kyoto Institute of Technology, Kyoto, Japan
    Nucleic Acids Res . 2016
    ..Ligation Assay (PLA) demonstrated that HP1a is in close proximity to DNA replication proteins including Mcm10, RFC140 and DNA polymerase ϵ 255 kDa subunit in S-phase. This was further confirmed by co-immunoprecipitation assay...
  96. pmc Partial Purification of a Megadalton DNA Replication Complex by Free Flow Electrophoresis
    Caroline M Li
    Department of Molecular and Cellular Biology, Beckman Research Institute at City of Hope, Duarte, California, United States of America
    PLoS ONE 11:e0169259. 2016
    ..I), DNA polymerase δ (Pol δ), DNA polymerase ɛ (Pol ɛ), replication protein A (RPA) and replication factor C (RFC)...
  97. pmc Control of Genome Integrity by RFC Complexes; Conductors of PCNA Loading onto and Unloading from Chromatin during DNA Replication
    Yasushi Shiomi
    Graduate School of Life Science, University of Hyogo, Kamigori, Ako gun, Hyogo 678 1297, Japan
    Genes (Basel) 8:. 2017
    ..PCNA is loaded onto chromatin by PCNA-loading replication factor C (RFC) complexes. Both RFC1-RFC and Ctf18-RFC fundamentally function as PCNA loaders...
  98. pmc BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    Y Wang
    Verna and Mars McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 14:927-39. 2000
    ..In addition, DNA replication factor C (RFC), a protein complex that facilitates the loading of PCNA onto DNA, is also part of BASC...
  99. ncbi Functional interaction of bZIP proteins and the large subunit of replication factor C in liver and adipose cells
    S Hong
    Hormone Research Center, Chonnam National University, Kwangju 500 757, Korea
    J Biol Chem 276:28098-105. 2001
    ..One of the strongest interactions was with RFC140, the large subunit of the replication factor C complex...
  100. pmc Human mismatch repair: reconstitution of a nick-directed bidirectional reaction
    Nicoleta Constantin
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:39752-61. 2005
    ..MutLalpha, EXOI, replication protein A (RPA), proliferating cell nuclear antigen (PCNA), replication factor C (RFC) and DNA polymerase delta...
  101. doi Derivation of a chronic reference dose and reference concentration for trimethylbenzenes and C9 aromatic hydrocarbon solvents
    Michael J Firth
    ExxonMobil Biomedical Sciences, Inc, Toxicology and Environmental Science, 1545 Route 22 East, P O Box 971, Annandale, NJ 08801 0971, USA
    Regul Toxicol Pharmacol 52:248-56. 2008
    ..inhalation studies were identified to serve as the basis for a Reference dose (RfD) and Reference concentrations (RfC). The RfD and RfC were derived using standard USEPA methods and assumptions. The RfD was calculated to be 0...

Research Grants62

  1. Larry H Matherly; Fiscal Year: 2015
    ..pemetrexate, raltitrexed and pralatrexate, are all transported by the ubiquitous, reduced folate carrier (RFC) into both tumor and normal host cells, and hence are nonselective for tumor cells and are consequently toxic...
  2. SHERMAINE KIMBERLY MITCHELL; Fiscal Year: 2014
    ..The latter has been attributed to intracellular membrane transport of Pmx by Reduced Folate Carrier (RFC)...
  3. Larry H Matherly; Fiscal Year: 2015
    ..is functionally and (to some degree) anatomically distinct from the ubiquitously expressed reduced folate carrier (RFC), the major tissue folate transporter...
  4. Alan E Tomkinson; Fiscal Year: 2016
    ..We have shown that hLigI interacts with PCNA, a DNA sliding clamp, and RFC, the loader that loads PCNA onto DNA and, using cell-based assays, we have demonstrated that these interactions are ..
  5. PCNA clamp mechanisms in DNA replication and repair
    Manju M Hingorani; Fiscal Year: 2010
    ..The plan is to investigate the mechanism of action of S. cerevisiae Replication Factor C clamp loader (RFC), a multi-protein complex that binds PCNA and DNA and creates a topological link between the two in an ATP-..
  6. Dorothy A Erie; Fiscal Year: 2016
    ..a nick, and it requires the exonuclease, Exo1 (although others may be involved), the clamp loader protein, RFC, and clamp protein, PCNA, DNA polymerase 6, in addition to MutS and MutL proteins, and repair is enhanced in the ..
  7. Arthur J Lustig; Fiscal Year: 2014
    ..two proteins that act in the same pathway with mre11-A470T: the cell-cycle protein Clb2 and the telomere-specific RFC component, Ctf18...
  8. JENNIFER LYNN STRIPAY; Fiscal Year: 2015
    ..Previous work [13] has identified a novel regulatory pathway (the redox/Fyn/c-Cbl (RFC)) pathway that is present in progenitor cells of the CNS, and appears to be dysregulated in GBM...
  9. Factors Regulating NE Transporter Localization in PFC
    Susan R Sesack; Fiscal Year: 2011
    The norepinephrine (NE) innervation to the prefrontal cortex (RFC) is involved in complex cognitive functioning, and pathologies in this system are implicated in mental health disorders including depression, post-traumatic stress ..
  10. Regulation of Adult Neurogenesis by Methamphetamine
    Chitra D Mandyam; Fiscal Year: 2012
    ..While the devastating effects of methamphetamine on the structure and function of the RFC and hippocampus are becoming very clear, very little information exists on the affects of methamphetamine on adult ..
  11. Transcriptional Role of BRCA1 in Breast Cancer
    Wen Hwa Lee; Fiscal Year: 2012
    ..To elucidate regulatory modes of BRCA1-mediated, but ZBRK1 independent, transcriptional modulation of FGF2, RFC1, TIP30 and TFDP1;and Aim 3...
  12. PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia Subjects
    Ghanshyam N Pandey; Fiscal Year: 2011
    ..The two brain areas often implicated in these disorders are the prefrontal cortex (RFC) and the cingulate cortex...
  13. Heavy Metal and Drug Self-Administration: Mechanisms
    PAUL JEFFERSON WELLMAN; Fiscal Year: 2010
    ..of drug challenges, 2) using standard radiobinding assays, binding of DA and Glu in the NAc and prefrontal cortex (RFC) will be examined for animals developmentally exposed to lead, 3) and, employing in situ hybridization techniques, ..
  14. Schizophrenia and Endocannabinoid Effects on Inhibitory Circuitry
    David W Volk; Fiscal Year: 2013
    ..Interestingly, deficits in RFC GABA neurons may lead to cognitive problems in schizophrenia, and cannabis reduces GABA signaling by activating the ..
  15. DA-GABA modulation of cortical ACh release
    John P Bruno; Fiscal Year: 2010
    ..injections, and operant behavior to reveal the coordinated neurochemical activity within the prefrontal cortex (RFC), NAC, and basal forebrain (BF) of the same animal...
  16. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2009
    ..adenosine deaminase), methionine adenosyl transferase 2A (MAT2A), folate receptor (FOLR1), reduced folate carrier (RFC1 or SLC19A1), S-adenosylmethionine decarboxylase (AMD1), gastric instrinsic factor (GIF), transcobalamin II (TCII), ..
  17. NEUROCHEMICAL EFFECTS OF ANTIPSYCHOTIC DRUGS
    Bita Moghaddam; Fiscal Year: 2012
    ..role of glutamatergic neurotransmission,in particular that ofjgiutamatergic efferents rom the prefrontal cortex (RFC), in the functional abnormalities that may be elated to schizophrenia...
  18. RADIOPAQUE FLUOROCARBON IN DIAGNOSTIC RADIOLOGY
    David Long; Fiscal Year: 1980
    Radiopaque fluorocarbons (RFC) are new compounds in diagnostic radiology, and these compounds have unique and valuable characteristics that are not shared with other radiologic contrast agents...
  19. Prefrontal and temporal lobe mechanisms of declarative memory
    Scott L Brincat; Fiscal Year: 2010
    ..correlated memory impairment and neurological dysfunction in the medial temporal lobe (MIL) and prefrontal cortex (RFC). Studies of focal brain damage suggest these two structures play distinct, specific roles in memory...
  20. Mechanism of PCNA-dependent 5'->3' Mismatch Excision
    Guo Min Li; Fiscal Year: 2010
    ..and involves at least nine proteins, which are MutS alpha, MutS beta, MutL alpha, EXO1, polymerase delta, PCNA, RFC, RPA, and HMGB1...
  21. RADIATION MUTAGENESIS AND REPAIR IN SACCHAROMYCES
    Christopher Lawrence; Fiscal Year: 1999
    ..In addition, the effects of other proteins, such as RFA, PCNA, and RFC, on translesion DNA synthesis will be examined. Fractionated cell extracts may also be tried...
  22. NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCER
    Jing Ma; Fiscal Year: 2007
    ..in adipocyte differentiation), VDR (FokI), IL-6, methionine syntheses reductase (MTRR), and reduced folate carrier (RFC-1)...
  23. Physiological, neural and cognitive bases of age-related working memory change
    BART P RYPMA; Fiscal Year: 2010
    ..Second, I will implement event-related fMRI procedures to test the hypothesis that dorsal prefrontal cortex (RFC) regions (that may underlie WM executive functions) are disproportionately age affected, compared to other, more ..
  24. Structure Studies of Processive DNA Replication
    John Kuriyan; Fiscal Year: 2010
    ..tethers the core to DMA, and a heteropentameric ATP- dependent clamp loader complex (gamma complex in bacteria, RFC in eukaryotes) that loads the clamps onto DNA and coordinates the efficient replication of both the leading and the ..
  25. REPAIR OF DNA DAMAGED BY UV IRRADIATION IN YEAST
    Louise Prakash; Fiscal Year: 2003
    ..will be reconstituted with highly purified components, and the role of Rev1 and other proteins such as PCNA and RFC in this process will be analyzed...
  26. MOLECULAR STUDIES OF FOLATE HOMEOSTASIS
    Charles Halsted; Fiscal Year: 2000
    ..hydrolase (BBFH) and the liver and kidney membrane folate binding protein (FBP) and reduced folate carrier (RFC); 2) to use human tissues to evaluate the relevance of the pig as a model for human folate homeostasis; and 3) ..
  27. fMRI Studies of Working Memory and Motivation
    MARK D ESPOSITO; Fiscal Year: 2007
    ..Reward representation and working memory are key functions of the prefrontal cortex (RFC), but their interactions are not well understood at the neural systems level...
  28. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
    ..Our preliminary data show that in addition to the hippocampus, the medial RFC is involved in long-term memory storage for trace fear conditioning, a hippocampal-dependent associative learning ..
  29. DNA REPAIR AND ITS RELATIONSHIP TO CARCINOGENESIS
    Errol Friedberg; Fiscal Year: 2001
    ..factors participate in NER and to establish the role(s) of DNA replication accessory proteins such as RFA, RFC and PCNA in NER in yeast...
  30. Use of PFCs to Improve O2 Transport In Liver Systems
    ROBIN COGER; Fiscal Year: 2007
    ..the relationship between the level of O2 supplied and the efficiency in which it is used by the cells when RFC-supplemented media is used as the O2 source...
  31. Frontal function in Adolescent Cannabis Use Disorders
    MICHAEL DE BELLIS; Fiscal Year: 2009
    ..neuropsychological battery and a functional MRI (fMRI) scan aimed at measuring subdivisions of prefrontal cortex (RFC) involved in decision-making and reward...
  32. Biochemical Analysis of the BRCA1 Protein Complex
    Jun Qin; Fiscal Year: 2007
    ..The specific aims are (1) To test the hypothesis that RFC and/or BLM within the BASC function upstream in the response to DNA replication stress, (2) To purify BRCA1 ..
  33. Vulnerability to Addiction: A Role for 5-HT2C Receptor Editing and Expression
    Stella Dracheva; Fiscal Year: 2007
    ..in order to relate 5-HT2CR mRNA editing and expression in the ventral tegmental area (VTA) and prefrontal cortex (RFC) to vulnerability to drug abuse...
  34. MOLECULAR DISSECTION OF YEAST NUCLEOTIDE EXCISION REPAIR
    Zhigang Wang; Fiscal Year: 2006
    ..proteins and protein factors: Rad1, Rad2, Rad4, Rad7, Rad10, Rad14, Rad16, Rad23, Mms19, TFIIH, RPA, PCNA, RFC, DNA polymerases delta and epsilon, and DNA ligase I...
  35. AUTORECOGNITION AND IMMUNOREACTIVITY
    JAMES SCHEFFEL; Fiscal Year: 1980
    ..research seeks to determine the immunological significance of autologous erythrocyte rosette-forming cells (A-RFC)...
  36. DNA REPLICAION, DNA REPAIR, AND THE CELL CYCLE IN YEAST
    MICHAEL MC ALEAR; Fiscal Year: 2000
    ..I have characterized the phenotypes of yeast cells bearing mutations in the genes that encode subunits of RFC and PCNA...
  37. Comparison of Frontal Cortex and Striatum during Visual Categorization
    JASON ANDREW CROMER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Normal cognition depends on interactions between the prefrontal cortex (RFC) and basal ganglia (BG)...
  38. MECHANISM OF HUMAN DNA POLYMERASE DELTA, RF-C AND PCNA
    MICHAEL O DONNELL; Fiscal Year: 1999
    ..The "PCNA clamp" does not assemble onto DNA by itself, it requires the matchmaking activity of the RFC complex...
  39. Effects of repeated cocaine administration in activity of cortical interneurons.
    Antonieta Lavin; Fiscal Year: 2007
    ..studies in humans and animals have implicated additional brain areas, particularly the prefrontal cortex (RFC)...
  40. Structure-Function Analysis of Rad17
    EDGARDO PARRILLA CASTELLAR; Fiscal Year: 2003
    ..Sequence alignments indicate that Rad17 shares homology with the RFC subunits. Moreover, Rad17 interacts with the small RFC subunits into an independent complex (Rad17-RFC)...
  41. Studies of Hierarchic Organization in Prefrontal Cortex
    David Badre; Fiscal Year: 2007
    ..The research proposed here seeks to test two related hypotheses regarding the organization of RFC control processes...
  42. Age-related Prefrontal Compensation in Long-term Memory
    Angela Gutchess; Fiscal Year: 2007
    This proposal investigates the mechanisms through which additional prefrontal (RFC) activity compensates for medial temporal (MTL) declines in long-term memory with age...
  43. Studies on the Checkpoint Regulation of DNA Synthesis
    Jerard Hurwitz; Fiscal Year: 2005
    ..We plan to examine: 1) the role of the newly discovered Rad17p complexed to the small RFC subunit 2, 3, 4 and 5 and its interaction with the Rad family of gene Products HUS1, Rad1 and Rad9; 2) the ..
  44. Crystallographic Investigations of Replication Factor C
    GREGORY BOWMAN; Fiscal Year: 2003
    ..cerevisiae, Replication Factor C (RFC), in the 'open' (ATP-bound) and "closed' (no nucleotide) conformations, and 2) crystal structure determination of a ..
  45. STUDIES OF THE NUCLEOTIDE EXCISION REPAIR PROTEIN XPC
    MARK BRANUM; Fiscal Year: 2003
    ..The proteins involved in this system are XPC-HR23B, XPA, RPA, TFIIH, XPG, XPF-ERCC1, RFC, PCNA, Pol epsilon or delta and DNA Ligase I...
  46. LIPOPHILIC ANTIFOLATES AND AIDS OPPORTUNISTIC INFECTIONS
    Andre Rosowsky; Fiscal Year: 2004
    ..Analogs of PT653 with a COOH, NH2, or OH group on the tricyclic moiety, and prodrugs thereof, will be made with the goal of improving aqueous solubility without sacrificing potency or selectivity. ..
  47. Enhancement of methotrexate uptake in childhood ALL
    John McGuire; Fiscal Year: 2009
    ..MTX polyglutamates primarily via a previously undiscovered enhancement in activity of the reduced folate carrier (RFC), which also transports MTX...
  48. STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
  49. FOLYLPOLYGLUTAMATE SYNTHETASE IN CANCER CHEMOTHERAPY
    John McGuire; Fiscal Year: 2003
    ..This may explain why high-level resistance to pulse MTX can occur in the absence of a large decrease in total FPGS activity or a rise in glutamyl hydrolase activity. ..
  50. ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONS
    Janee Gelineau van Waes; Fiscal Year: 2003
    ..abstract_text> ..
  51. NOVEL APPROACHES TO ANTIFOLATE CHEMOTHERAPY
    Andre Rosowsky; Fiscal Year: 2003
    ..The focus will be on enhancing polyglutamation of the lead compound dmAMT by modification of the B-ring and/or pABA moiety. ..
  52. Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents
    Aleem Gangjee; Fiscal Year: 2010
    ..The design of a cytotoxic agent that itself selectively targets the FR-alpha and is not appreciably taken up by the RFC would afford highly selective agents against FR-alpha expressing tumors without serious toxicity...
  53. Third Generation Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2003
    ..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
  54. Metabolic Biomarkers of Autism: Predictive Potential and Genetic Susceptibility
    SANDRA JILL JAMES; Fiscal Year: 2010
    ....
  55. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..abstract_text> ..
  56. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ....
  57. Antitumor Antimitotics That Reverse Tumor Resistance
    Aleem Gangjee; Fiscal Year: 2010
    ..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
  58. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..abstract_text> ..
  59. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  60. NSAID and COX/PG Metabolism and Colorectal Cancer
    Cornelia Ulrich; Fiscal Year: 2009
    ..Ultimately, such information on the metabolic variation will be useful in optimizing NSAIDs and NSAID regimens and will allow individual tailoring of chemoprevention. ..
  61. 3 Tesla Magnetic Resonance Imaging Scanner
    Weili Lin; Fiscal Year: 2003
    ..Overall, the presence of the 3T MR scanner is likely to have profound implications for biomedical research at UNC-Chapel Hill. ..
  62. A randomized trial of influenza vaccination of Hutterite children
    Mark Loeb; Fiscal Year: 2006
    ..We believe that the trial we propose will lead to important data that can inform policy on influenza immunization strategy. [unreadable] [unreadable] [unreadable]..