S100A2

Summary

Gene Symbol: S100A2
Description: S100 calcium binding protein A2
Alias: CAN19, S100L, protein S100-A2
Species: human

Top Publications

  1. ncbi Differential responses of S100A2 to oxidative stress and increased intracellular calcium in normal, immortalized, and malignant human keratinocytes
    Tong Zhang
    Department of Dermatology, University of Michigan, Ann Arbor 48109, USA
    J Invest Dermatol 119:1196-201. 2002
  2. ncbi Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation
    R Wicki
    Department of Pediatrics, University of Zurich, Switzerland
    Cell Calcium 22:243-54. 1997
  3. ncbi Binding of Ca2+ and Zn2+ to human nuclear S100A2 and mutant proteins
    C Franz
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, CH 8032 Zurich, Switzerland
    J Biol Chem 273:18826-34. 1998
  4. ncbi Subcellular distribution of S100 proteins in tumor cells and their relocation in response to calcium activation
    A Mueller
    Department of Pediatrics, University of Zurich, Switzerland
    Histochem Cell Biol 111:453-9. 1999
  5. ncbi The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity
    Andrea Mueller
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, Steinwiesstrasse 75, 8032 Zurich
    J Biol Chem 280:29186-93. 2005
  6. ncbi S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation
    E Lapi
    Department of Experimental Oncology, Regina Elena Cancer Institute, Rome, Italy
    Oncogene 25:3628-37. 2006
  7. ncbi Down-regulation of S100A2 in lymph node metastases of head and neck cancer
    Xin Zhang
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA
    Head Neck 29:236-43. 2007
  8. pmc Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site
    Ralf D Kirschner
    Interdisziplinares Zentrum fur Klinische Forschung IZKF, Frauenklinik, Medizinische Fakultat, Universitat Leipzig, Semmelweisstrasse, 14, D 04103 Leipzig, Germany
    Nucleic Acids Res 36:2969-80. 2008
  9. pmc Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain
    Seiko Shimamoto
    Department of Signal Transduction Sciences, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Kita gun, Kagawa 761 0793, Japan
    J Biol Chem 283:28246-58. 2008
  10. doi S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats
    Seiko Shimamoto
    Department of Signal Transduction Sciences, Kagawa University Faculty of Medicine, Kita gun, Kagawa, Japan
    FEBS Lett 584:1119-25. 2010

Research Grants

  1. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
  2. The Structure and Function of S100 Proteins
    DAVID JOSEPH WEBER; Fiscal Year: 2010
  3. Organ Culture of Basal Cell Carcinoma
    James Elder; Fiscal Year: 2002
  4. Dendritic Cell Immunotherapy for Cervical Cancer
    Alessandro Santin; Fiscal Year: 2004
  5. Amphiregulin in Psoriatic Epidermal Hyperplasia
    JAMES TILFORD ELDER; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications135 found, 100 shown here

  1. ncbi Differential responses of S100A2 to oxidative stress and increased intracellular calcium in normal, immortalized, and malignant human keratinocytes
    Tong Zhang
    Department of Dermatology, University of Michigan, Ann Arbor 48109, USA
    J Invest Dermatol 119:1196-201. 2002
    b>S100A2 is a calmodulin-like, p53-inducible, homodimeric protein that is readily oxidized in keratinocytes subjected to oxidative stress...
  2. ncbi Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation
    R Wicki
    Department of Pediatrics, University of Zurich, Switzerland
    Cell Calcium 22:243-54. 1997
    The calcium-binding protein S100A2 is expressed in normal breast tissue but downregulated during breast cancer progression. Hence it was previously identified as a candidate tumor suppressor gene...
  3. ncbi Binding of Ca2+ and Zn2+ to human nuclear S100A2 and mutant proteins
    C Franz
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, CH 8032 Zurich, Switzerland
    J Biol Chem 273:18826-34. 1998
    The Ca2+-binding protein S100A2 is an unusual member of the S100 family, characterized by its nuclear localization and down-regulated expression in tumorigenic cells...
  4. ncbi Subcellular distribution of S100 proteins in tumor cells and their relocation in response to calcium activation
    A Mueller
    Department of Pediatrics, University of Zurich, Switzerland
    Histochem Cell Biol 111:453-9. 1999
    ..The present work demonstrates a distinct intracellular localization of S100A6, S100A4, and S100A2 in two tumor cell lines derived from metastatic epithelial breast adenocarcinoma (MDA-MB231) and cervical ..
  5. ncbi The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity
    Andrea Mueller
    Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, Steinwiesstrasse 75, 8032 Zurich
    J Biol Chem 280:29186-93. 2005
    Head and neck squamous cell carcinoma express high levels of the EF-hand calcium-binding protein S100A2 in contrast to other tumorigenic tissues and cell lines where the expression of this protein is reduced...
  6. ncbi S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation
    E Lapi
    Department of Experimental Oncology, Regina Elena Cancer Institute, Rome, Italy
    Oncogene 25:3628-37. 2006
    ..Indeed, both p73- and p63-deficient mice exhibit severe developmental defects. Here, we show that S100A2 gene, whose transcript and protein are induced during keratinocyte differentiation of HaCaT cells, is a direct ..
  7. ncbi Down-regulation of S100A2 in lymph node metastases of head and neck cancer
    Xin Zhang
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA
    Head Neck 29:236-43. 2007
    Our cDNA microarray analysis of squamous cell carcinoma of the head and neck (SCCHN) previously identified that S100A2 was down-regulated in highly metastatic 686LN-M3s cell lines established through in vivo selection using a metastatic ..
  8. pmc Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site
    Ralf D Kirschner
    Interdisziplinares Zentrum fur Klinische Forschung IZKF, Frauenklinik, Medizinische Fakultat, Universitat Leipzig, Semmelweisstrasse, 14, D 04103 Leipzig, Germany
    Nucleic Acids Res 36:2969-80. 2008
    b>S100A2 is generally found expressed in the epidermis and was recently shown to play a crucial role in the differentiation of keratinocytes. Also known as CaN19, S100A2 was identified as a potential tumor suppressor...
  9. pmc Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain
    Seiko Shimamoto
    Department of Signal Transduction Sciences, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Kita gun, Kagawa 761 0793, Japan
    J Biol Chem 283:28246-58. 2008
    b>S100A2 and S100A6 interact with several target proteins in a Ca2+-regulated manner. However, the exact intracellular roles of the S100 proteins are unclear...
  10. doi S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats
    Seiko Shimamoto
    Department of Signal Transduction Sciences, Kagawa University Faculty of Medicine, Kita gun, Kagawa, Japan
    FEBS Lett 584:1119-25. 2010
    ..Using glutathione-S transferase pull-down assays and immunoprecipitation, we have demonstrated that S100A1 and S100A2 specifically interact with the TPR domains of FKBP52 and CyP40 in a Ca(2+)-dependent manner, and lead to ..
  11. pmc Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein)
    Seiko Shimamoto
    Department of Signal Transduction Sciences, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, Japan
    J Biol Chem 288:7158-68. 2013
    ..GST pulldown assays indicated that Ca(2+)/S100A2 and S100P bind to the TPR domain and lead to interference with the interactions of CHIP with Hsp70, Hsp90, HSF1, ..
  12. ncbi Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions
    R Boni
    Department of Dermatology, University of Zurich, Switzerland
    Br J Dermatol 137:39-43. 1997
    The purpose of this study was to evaluate the expression of the Ca(2+)-binding S100 proteins S100A1, S100A2, S100A3, S100A4, S100A6 and S100B in normal skin...
  13. ncbi Biochemical characterization of S100A2 in human keratinocytes: subcellular localization, dimerization, and oxidative cross-linking
    R Deshpande
    Departments of Dermatology and Radiation Oncology Cancer Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Invest Dermatol 115:477-85. 2000
    b>S100A2 is a calmodulin-like protein of unknown function, whose transcription is positively regulated in response to ErbB and p53 signaling...
  14. ncbi Identification of S100A2 as a target of the DeltaNp63 oncogenic pathway
    Kenji Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Clin Cancer Res 9:4282-5. 2003
    ..To gain additional insight into this pathway, we examined global patterns of gene expression in cancer cells after DeltaNp63 gene introduction using the oligonucleotide microarray approach...
  15. pmc Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment
    S W Lee
    Division of Cancer Genetics, Dana Farber Cancer Institute, Boston, MA
    Proc Natl Acad Sci U S A 89:2504-8. 1992
    A cDNA clone, designated CaN19 (originally called clone 19), isolated by subtractive hybridization, contains sequences that are preferentially expressed in normal mammary epithelial cells but not in breast tumor cells...
  16. doi Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53
    Jan van Dieck
    MRC Laboratory of Molecular Biology and MRC Center for Protein Engineering, Hills Road, Cambridge CB2 0QH, UK
    J Mol Biol 394:922-30. 2009
    ..Here, we found that S100A1, S100A2, S100A4, S100A6, and S100B bound to two subdomains of the TAD (TAD1 and TAD2)...
  17. pmc Isolation of a new member of the S100 protein family: amino acid sequence, tissue, and subcellular distribution
    J R Glenney
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, San Diego, California 92138
    J Cell Biol 108:569-78. 1989
    A low molecular mass protein which we term S100L was isolated from bovine lung...
  18. ncbi Expression analysis of S100 proteins and RAGE in human tumors using tissue microarrays
    Hsiao Ling Hsieh
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, Switzerland
    Biochem Biophys Res Commun 307:375-81. 2003
    ..The results validated the expression of S100A4, S100A6, and S100B in specific tumor types. A significant S100A2 expression was observed in lymphoma biopsies, which implies a possible link between this S100 protein and lymphoma ..
  19. doi S100 proteins interact with the N-terminal domain of MDM2
    Jan van Dieck
    MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, UK
    FEBS Lett 584:3269-74. 2010
    ..This interaction with MDM2 (2-125) is a general feature of S100 proteins; S100A1, S100A2, S100A4 and S100A6 also interact with MDM2 (2-125)...
  20. ncbi Promoter hyper-methylation of calcium binding proteins S100A6 and S100A2 in human prostate cancer
    Ishtiaq Rehman
    Academic Urology Unit, Division of Clinical Sciences South, University of Sheffield, United Kingdom, and Service d Urologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Prostate 65:322-30. 2005
    S100A6 and S100A2 are members of the S100 family of calcium binding proteins, which are down regulated in prostate cancer, however the molecular mechanism(s) underlying their loss of expression is unknown.
  21. ncbi Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation
    Rajyalakshmi Luthra
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Clin Oncol 24:259-67. 2006
    ..Currently, however, there are no tools to help select optimum therapy. We hypothesized that gene expression profiling could provide clues and biomarkers for selection of therapy...
  22. ncbi Gastric cancers overexpress S100A calcium-binding proteins
    Wa el El-Rifai
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0708, USA
    Cancer Res 62:6823-6. 2002
    ..Interestingly, five calcium-binding proteins (S100A2, S100A7, S100A8, S100A9, and S100A10) were overexpressed...
  23. ncbi Expression of S100A2 and S100B proteins in epithelial tumors of the skin
    Hye Rim Park
    Department of Pathology, College of Medicine, Hallym University, Anyang, Korea
    J Cutan Pathol 30:373-8. 2003
    The purpose of this study was to evaluate the expression of Ca2+-binding S100 proteins, S100A2 and S100B, in normal skin. These immunohistochemical stain patterns were compared with those in a variety of epithelial tumors.
  24. ncbi Identification and characterization of genes responsive to apoptosis: application of DNA chip technology and mRNA differential display
    Y Sun
    Department of Molecular Biology, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Histol Histopathol 15:1271-84. 2000
    ..mediate apoptosis in p53 dependent manner (through activation of p53 target genes such as Waf-1/p21, PCNA, GPX, S100A2 and PTGF-beta) as well as in p53-independent manner (through activation of ODC and TGF-beta receptor, among others)..
  25. pmc Combination PPARgamma and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2
    Joshua P Klopper
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    PPAR Res 2010:729876. 2010
    ..analysis of A375(DRO) after TZD and combination rexinoid/TZD treatment in which the calcium binding protein S100A2 had increased expression after rexinoid or TZD treatment and a synergistic increase to combination treatment...
  26. ncbi Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy
    Alessandro D Santin
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Int J Cancer 112:14-25. 2004
    ..claudin 3, claudin 4, tumor-associated calcium signal transducers 1 and 2 (TROP-1/Ep-CAM, TROP-2), ladinin 1, S100A2, SERPIN2 (PAI-2), CD24, lipocalin 2, osteopontin, kallikrein 6 (protease M), kallikrein 10, matriptase (TADG-15) ..
  27. ncbi Cyclooxygenase-2 is involved in S100A2-mediated tumor suppression in squamous cell carcinoma
    Wan Chi Tsai
    Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan, Republic of China
    Mol Cancer Res 4:539-47. 2006
    b>S100A2 is considered a putative tumor suppressor due to its loss or down-regulation in several cancer types. However, no mechanism has been described for the tumor suppressor role of S100A2...
  28. doi The expression of COX-2, hTERT, MDM2, LATS2 and S100A2 in different types of non-small cell lung cancer (NSCLC)
    Mojca Strazisar
    Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia
    Cell Mol Biol Lett 14:442-56. 2009
    ..transcription polymerase chain reaction (RT-PCR), we analysed the expression of the COX-2, hTERT, MDM2, LATS2 and S100A2 genes and researched the relationships between the NSCLC types and the differences in expression levels...
  29. ncbi S100-mediated signal transduction in the nervous system and neurological diseases
    D B Zimmer
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77845 4467, USA
    Cell Mol Biol (Noisy-le-grand) 51:201-14. 2005
    ..A total of ten S100 family members are reported in the literature to be expressed in brain -S100A1, S100A2, S100A4, S100A5, S100A6, S100A10, S100A11, S100A13, S100B, and S100Z...
  30. ncbi Decitabine up-regulates S100A2 expression and synergizes with IFN-gamma to kill uveal melanoma cells
    Jared A Gollob
    Division of Medical Oncology, Department of Medicine, Duke University, Durham, NC 27710, USA
    Clin Cancer Res 13:5219-25. 2007
    ..Metastatic uveal melanoma is resistant to conventional chemotherapy and immunotherapy. In this study, we investigated the responsiveness of uveal melanoma cell lines to IFNs and the hypomethylating agent decitabine...
  31. ncbi Molecular cloning, identification and analysis of lung squamous cell carcinoma-related genes
    Chenyang Shen
    Department of Thoracic Surgery, People s Hospital, Peking University, Beijing 100044, China
    Lung Cancer 38:235-41. 2002
    ..To clone and identify genes differentially expressed in human lung squamous cell carcinoma (LSCC)...
  32. ncbi cDNA cloning of S100 calcium-binding proteins from bovine periodontal ligament and their expression in oral tissues
    W R Duarte
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Japan
    J Dent Res 77:1694-9. 1998
    ..screened the PDL cDNA library with a mouse S100A4 cDNA, and cloned the bovine cDNAs of two S100 CaBPs (S100A4 and S100A2). In northern blotting analysis, the highest expression of S100A4 was detected in PDL from erupted teeth (PDLE)...
  33. pmc Expression of calcium-binding protein S100A2 in breast lesions
    D Liu
    School of Biological Sciences, University of Liverpool, P O Box 147, Liverpool, L69 7ZB, UK
    Br J Cancer 83:1473-9. 2000
    ..contained cDNAs corresponding to mRNAs for plasminogen activator inhibitor I, annexin VIII and the EF-hand protein S100A2. S100A2 protein has previously been shown to be expressed in normal human breast epithelium, but not in human ..
  34. ncbi Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca(2+)-binding S100 proteins
    Y Bronckart
    Laboratory of Histopathology, Faculty of Medicine, Free University of Brussels, Belgium
    Histol Histopathol 16:707-12. 2001
    The expression levels of seven different S100 proteins (S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, and S100B) were characterized by immunohistochemistry in the epithelial versus connective tissues of a series of 35 colon specimens, ..
  35. ncbi S100P expression in human esophageal epithelial cells: Human esophageal epithelial cells sequentially produce different S100 proteins in the process of differentiation
    Nobuyuki Sato
    Department of Anatomy and Histology, Niigata University Faculty of Medicine, Niigata City, Niigata, Japan
    Anat Rec 267:60-9. 2002
    ..We also investigated the expression of other S100 proteins, including S100A2, S100A6, and CAAF1 (S100A12), in human EECs...
  36. ncbi Differential expression of S100A2 and S100A4 during progression of human prostate adenocarcinoma
    Sanjay Gupta
    Department of Urology, Case Western Reserve University and The Research Institute of University Hospitals of Cleveland, Cleveland, OH, USA
    J Clin Oncol 21:106-12. 2003
    To establish the clinical significance of calcium binding proteins S100A2 and S100A4 during progression of human prostate adenocarcinoma.
  37. ncbi S100A protein expression in the distinction between lentigo maligna and pigmented actinic keratosis
    Adriana Ribe
    Department of Pathology, New York Presbyterian Hospital Cornell University Weill Medical College, New York, New York, USA
    Am J Dermatopathol 25:93-9. 2003
    ..Our study analyzed the expression of several of the S100 protein subtypes (S100A2, S100A6, and S100A8/A9 or A12) in 38 LM cases and 44 PAK cases to define their potential value in the distinction ..
  38. ncbi Differential expression of S100 calcium-binding proteins in epidermoid cysts, branchial cysts, craniopharyngiomas and cholesteatomas
    P Pelc
    Department of Otolaryngology and Head and Neck Surgery, Erasmus University Hospital, Laboratory of Anatomy and Embryology, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Histopathology 42:387-94. 2003
    To investigate whether epidermoid cysts, branchial cysts, craniopharyngiomas and cholesteatomas express S100 proteins differentially by immunohistochemical assaying the presence of S100A1, S100A2, S100A3, S100A4, S100A5, S100A6 and S100B.
  39. ncbi S100 proteins in the epidermis
    Richard L Eckert
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Invest Dermatol 123:23-33. 2004
    ..genes are located within the epidermal differentiation complex on human chromosome 1q21 and 13 S100 proteins (S100A2, S100A3, S100A4, S100A6, S100A7, S100A8, S100A9, S100A10, S100A11, S100A12, S100A15, S100B, and S100P) are ..
  40. ncbi Overexpression of S100A2 protein as a prognostic marker for patients with stage I non small cell lung cancer
    Huijun Wang
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 116:285-90. 2005
    b>S100A2, a calcium-binding protein, recently became of major interest because of its differential expression during transformation and metastasis in various tumors...
  41. ncbi S100A8 is identified as a biomarker of HPV18-infected oral squamous cell carcinomas by suppression subtraction hybridization, clinical proteomics analysis, and immunohistochemistry staining
    Wan Yu Lo
    Department of Medical Research, China Medical University Hospital Taichung, Taiwan
    J Proteome Res 6:2143-51. 2007
    ..of HPV18+ OSCC, including poly(ADP-ribose)polymerase I (PARP1), replication protein A2 (RPA2), S100A8, and S100A2. Clinical proteomics analysis indicated that there was over 10-fold overexpression of Stratifin, F-actin capping ..
  42. ncbi Expression of S100 protein family members in the pathogenesis of bladder tumors
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA
    Anticancer Res 27:3051-8. 2007
    ..were confirmed by real-time PCR to be differentially expressed in human bladder cancers, with overexpression of S100A2, S100A3, S100A5, S100A7, S100A8, S100A9, S100A14, S100A15, S100A16 and S100P, and underexpression of S100A1, ..
  43. pmc In silico analysis and verification of S100 gene expression in gastric cancer
    Ji Liu
    Department of Gastrointestinal Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, PR China
    BMC Cancer 8:261. 2008
    ..They were involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. However, the expression status of S100 family members in gastric cancer was not known yet...
  44. doi Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer
    Andrew V Biankin
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
    Gastroenterology 137:558-68, 568.e1-11. 2009
    ..We evaluated the utility of multiple biomarkers from distinct biologic pathways as potential predictive markers of response to pancreatectomy and patient survival...
  45. pmc Significance of S100A2 and S100A4 Expression in the Progression of Prostate Adenocarcinoma
    Yong Wook Kwon
    Department of Urology, Chung Ang University College of Medicine, Seoul, Korea
    Korean J Urol 51:456-62. 2010
    The aim of this study was to investigate the expression pattern of calcium-binding proteins S100A2 and S100A4. We also sought to determine the prognostic value of these markers for patients with prostate adenocarcinoma.
  46. pmc Crystallization and calcium/sulfur SAD phasing of the human EF-hand protein S100A2
    Michael Koch
    Department of Biology, University of Konstanz, Postfach M665, Universitatsstrasse 10, 78457 Konstanz, Germany
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:1032-6. 2010
    Human S100A2 is an EF-hand protein and acts as a major tumour suppressor, binding and activating p53 in a Ca2+-dependent manner...
  47. doi Loss of Reprimo and S100A2 expression in human gastric adenocarcinoma
    Jun Luo
    Department of Pathology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    Diagn Cytopathol 39:752-7. 2011
    Reprimo and S100A2 are two newly identified candidate tumor-suppressor genes, which play an important role in the regulation of p53-dependent cell cycle...
  48. doi Regulation of nuclear localization signal-importin α interaction by Ca2+/S100A6
    Maki Takata
    Department of Signal Transduction Sciences, Kagawa University, Faculty of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    FEBS Lett 584:4517-23. 2010
    ..These results indicate S100A6 may regulate the nuclear transport of NLS-cargos in response to increasing concentrations of intracellular Ca(2+)...
  49. doi Joining S100 proteins and migration: for better or for worse, in sickness and in health
    Stephane R Gross
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
    Cell Mol Life Sci 71:1551-79. 2014
    ..This review summarises some of the reported regulatory functions of S100 proteins (namely S100A1, S100A2, S100A4, S100A6, S100A7, S100A8/S100A9, S100A10, S100A11, S100A12, S100B and S100P) on cellular migration and ..
  50. doi Suramin is a novel activator of PP5 and biphasically modulates S100-activated PP5 activity
    Fuminori Yamaguchi
    Department of Cell Physiology, Faculty of Medicine, Kagawa University, 1750 1, Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Appl Biochem Biotechnol 172:237-47. 2014
    ..In the presence of S100A2/Ca(2+), lower concentrations of suramin dose-dependently inhibited PP5 activity as an S100 antagonist, whereas ..
  51. doi Ca2+/S100 proteins inhibit the interaction of FKBP38 with Bcl-2 and Hsp90
    Seiko Shimamoto
    Department of Signal Transduction Sciences, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Biochem J 458:141-52. 2014
    ..In vitro binding studies demonstrated that S100A1, S100A2, S100A6, S100B and S100P specifically interact with FKBP38 and inhibit the interaction of FKBP38 with Bcl-2 and ..
  52. doi Clinical significance of S100A2 expression in gastric cancer
    Ying Fu Liu
    Department of Basic Medical Sciences, Medical College, Xiamen University, Xiangan South Road, Xiangan District, 361102, Xiamen, Fujian, China
    Tumour Biol 35:3731-41. 2014
    ..As a result, S100A2 was successfully identified to be down-regulated significantly in GC compared with ANGT...
  53. doi S100A2 protein and non-small cell lung cancer. The dual role concept
    Panagiotis Hountis
    Department of Thoracic Surgery, Athens Naval Hospital, Deinokratous 70, 11521, Athens, Greece
    Tumour Biol 35:7327-33. 2014
    b>S100A2 is a member of the EF-hand motif family S100. Its role has been recently implicated in carcinogenesis and metastasis...
  54. doi The receptor for advanced glycation end products influences the expression of its S100 protein ligands in melanoma tumors
    Varsha Meghnani
    Department of Pharmaceutical Sciences, North Dakota State University, Dept 2665, PO Box 6050, Fargo, ND 58108, United States
    Int J Biochem Cell Biol 57:54-62. 2014
    ..Analysis of protein tumor extracts showed increased levels of the RAGE ligands S100B, S100A2, S100A4, S100A6 and S100A10 in RAGE overexpressing tumors compared to control tumors...
  55. pmc Comparative Proteomic Analysis of Human Cholangiocarcinoma Cell Lines: S100A2 as a Potential Candidate Protein Inducer of Invasion
    Kasima Wasuworawong
    Department of Biochemistry, Faculty of Science, Mahidol University, 272 Rama VI Road, Bangkok 10400, Thailand
    Dis Markers 2015:629367. 2015
    ..b>S100A2, a calcium-binding protein in S100 protein family, is upregulated in KKU-M213...
  56. pmc Overexpression of the S100A2 protein as a prognostic marker for patients with stage II and III colorectal cancer
    Taiki Masuda
    Department of Surgical Oncology, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo 113 8510, Japan
    Int J Oncol 48:975-82. 2016
    ..Of these proteins, the S100 calcium-binding protein A2 (S100A2) has been observed in several human cancers...
  57. doi Transcriptome analysis of phycocyanin inhibitory effects on SKOV-3 cell proliferation
    Jun Ying
    School of Laboratory Medicine and Life Science Institute of Biomedical Informatics, Wenzhou Medical University, Wenzhou 325035, China
    Gene 585:58-64. 2016
    ..qPCR results further showed that PTPN12, S100A2, RPL26, and LAMA3 increased while HNRNPA1P10 decreased in PC-treated cells...
  58. ncbi S100A13. Biochemical characterization and subcellular localization in different cell lines
    K Ridinger
    Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zurich, 8032 Zurich, Switzerland
    J Biol Chem 275:8686-94. 2000
    ..In human smooth muscle cells, which co-express S100A2 in the nucleus and S100A1 in stress fibers, S100A13 shows a unique subcellular localization in the perinuclear ..
  59. ncbi Co-expression/co-location of S100 proteins (S100B, S100A1 and S100A2) and protein kinase C (PKC-beta, -eta and -zeta) in a rat model of cerebral basilar artery vasospasm
    F Lefranc
    Department of Neurosurgery, Erasmus University Hospital, Belgium
    Neuropathol Appl Neurobiol 31:649-60. 2005
    ..A number of S100 proteins are known to interfere directly with PKC, or indirectly with PKC substrates. We therefore investigated whether specific S100 proteins and PKCs are co-expressed/co-located in a rat model of SAH-induced vasospasm...
  60. ncbi Interferon-alpha and transforming growth factor-beta co-induce growth inhibition of human tumor cells
    S Foser
    Roche Center for Medical Genomics, F Hoffmann La Roche AG, 4070, Basel, Switzerland
    Cell Mol Life Sci 63:2387-96. 2006
    ..Among these are the insulin-like growth factor-binding protein 3 (IGFBP3) and the calcium-binding protein S100A2; we demonstrate, that recombinant IGFBP3 protein is a potent growth inhibitor requiring TGF-beta activity...
  61. ncbi S100A2-S100P expression profile and diagnosis of non-small cell lung carcinoma: impairment by advanced tumour stages and neoadjuvant chemotherapy
    Babett Bartling
    Department of Cardio Thoracic Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 61120 Halle Saale, Germany
    Eur J Cancer 43:1935-43. 2007
    ..Among the S100 members, we identified the expression of S100A1, S100A2, S100A4, S100A6, S100A9 and S100P in human lung carcinoma cells (H358(p53-), A549(p53+)) or NSCLC tissues...
  62. doi Locus 1q21 Gene expression changes in atopic dermatitis skin lesions: deregulation of small proline-rich region 1A
    Jerzy Jarzab
    Department of Internal Medicine, Dermatology and Allergology, Silesian Medical University, Zabrze, Poland
    Int Arch Allergy Immunol 151:28-37. 2010
    ..In the present study, we compared 1q21 gene expression in lesional versus nonlesional AD skin...
  63. doi S100A2 promoter-driven conditionally replicative adenovirus targets non-small-cell lung carcinoma
    K Lee
    Gene Therapy Laboratory, Mogam Biotechnology Research Institute, Yongin, Republic of Korea
    Gene Ther 19:967-77. 2012
    b>S100A2, a member of the S100 family of calcium-binding proteins, has been implicated in carcinogenesis as both a tumor suppressor and stimulator...
  64. pmc S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation
    Fuminori Yamaguchi
    Department of Cell Physiology, Kagawa University Faculty of Medicine, 1750 1, Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Biol Chem 287:13787-98. 2012
    ..In vitro binding studies demonstrated that S100A1, S100A2, S100A6, and S100B proteins specifically interact with PP5-TPR and inhibited the PP5-Hsp90 interaction...
  65. doi Identification of RARRES1 as a core regulator in liver fibrosis
    Andreas Teufel
    Department of Medicine I, Johannes Gutenberg University, Building 605, Langenbeckstr 1, 55101 Mainz, Germany
    J Mol Med (Berl) 90:1439-47. 2012
    ..RARRES1, AGER and S100A2 were differentially regulated in all fibrosis experiments...
  66. pmc Prognostic significance of different immunohistochemical S100A2 protein expression patterns in patients with operable nonsmall cell lung carcinoma
    Panagiotis Hountis
    Department of Thoracic Surgery, Athens Naval Hospital, Athens
    Onco Targets Ther 5:363-73. 2012
    S100 proteins are involved in carcinogenesis, metastasis, and survival. S100A2 is a member of the S100 family, and its expression and precise role in patients with non-small cell lung carcinoma (NSCLC) has been debated...
  67. ncbi Predictors of short-term neurocognitive outcome following coronary revascularisation (CABG) depending on the use of cardiopulmonary bypass
    Ines Lazibat
    University of Zagreb, Dubrava University Hospital, Department of Neurology, Zagreb, Croatia
    Coll Antropol 36:827-33. 2012
    ..The serum levels of the neuromarker S100l were measured immediately after surgery, and then 12, 24 and 48 hours after the surgery...
  68. doi Clinical significance of altered S100A2 expression in gastric cancer
    Ying Zhao
    Department of General Surgery, Shengjing Hospital of China Medical University, and Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, Liaoning 110004, PR China
    Oncol Rep 29:1556-62. 2013
    The S100A2 gene has been reported to be a putative tumor‑suppressor gene. Nevertheless, overexpression of S100A2 has been found in certain types of cancer...
  69. doi S100A2 is a predictive biomarker of adjuvant therapy benefit in pancreatic adenocarcinoma
    Jean Baptiste Bachet
    Medical University Pierre et Marie Curie, UFR Paris VI, 91 105 boulevard de l Hôpital, Paris, France
    Eur J Cancer 49:2643-53. 2013
    Prognosis of patients with pancreatic adenocarcinoma (PAC) remains poor. S100A2 has been recently suggested as a negative prognostic biomarker in PAC...
  70. pmc Novel interactions of the TRTK12 peptide with S100 protein family members: specificity and thermodynamic characterization
    Lucas N Wafer
    Department of Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, United States
    Biochemistry 52:5844-56. 2013
    ..Novel interactions were found with only two family members, S100P and S100A2, indicating that TRTK12 selectively interacts with a small subset of the S100 proteins...
  71. doi Low-molecular-mass secretome profiling identifies C-C motif chemokine 5 as a potential plasma biomarker and therapeutic target for nasopharyngeal carcinoma
    Shih Jie Lin
    Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    J Proteomics 94:186-201. 2013
    ..RPL22, and CCL5) in NPC tissues by immunohistochemistry and demonstrated elevated plasma levels of two targets (S100A2 and CCL5) in NPC patients by ELISA. Notably, plasma CCL5 showed good power (AUC 0...
  72. ncbi Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins
    M Gimona
    Cold Spring Harbor Laboratory, NY 11724, USA
    J Cell Sci 110:611-21. 1997
    ..with 1-ethyl-3-[3-(dimethyl amino)propyl]carbodiimide (EDC) indicated an association of the Ca2+-binding protein S100A2 with tropomyosin (TM) in vitro...
  73. ncbi A model for target protein binding to calcium-activated S100 dimers
    P Groves
    Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Warsaw, Poland
    FEBS Lett 421:175-9. 1998
    ..We conclude that the differences are a result of modeling rather than a function of different target binding properties. A mechanism for target protein binding is suggested...
  74. ncbi Distinct subcellular localization of calcium binding S100 proteins in human smooth muscle cells and their relocation in response to rises in intracellular calcium
    A Mandinova
    Maurice E Müller Institute, BioCentrum, University of Basel, Switzerland
    J Cell Sci 111:2043-54. 1998
    ..In contrast, S100A2 was located primarily in the cell nucleus...
  75. pmc Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family
    T Shishibori
    Department of Chemistry, Kagawa Medical University, 1750 1, Miki cho, Kita gun, 761 0793 Kagawa, Japan
    Biochem J 338:583-9. 1999
    ..that two characteristic 10-kDa proteins, one polar and one less polar, were bound with all three drugs, although S100A2 (S100L), of the S100 family, was bound with phenyl-Sepharose...
  76. ncbi Mapping the zinc ligands of S100A2 by site-directed mutagenesis
    T B Stradal
    Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences, Billrothstrasse 11, A 5020 Salzburg, Austria
    J Biol Chem 275:13219-27. 2000
    ..In addition to Ca(2+), several members of the S100 protein family, including S100A2, bind Zn(2+)...
  77. ncbi Prognostic significance of the Ca(2+) binding protein S100A2 in laryngeal squamous-cell carcinoma
    L Lauriola
    Institute of Pathology, Universita Cattolica del S Cuore, Rome, Italy
    Int J Cancer 89:345-9. 2000
    We investigated by immunocytochemistry the expression of the Ca(2+) binding protein S100A2 in 62 cases of laryngeal squamous-cell carcinoma (SCC)...
  78. ncbi Coordinately up-regulated genes in ovarian cancer
    C D Hough
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, MD 21224, USA
    Cancer Res 61:3869-76. 2001
    ..Kop protease inhibitor, matrix gla protein, tissue inhibitor of metalloproteinase 3, folate receptor 1, S100A2, signal transducer and activator of transcription 1, secretory leukocyte protease inhibitor, apolipoprotein E, and ..
  79. ncbi Evidence for local control of gene expression in the epidermal differentiation complex
    James T Elder
    Department of Dermatology, University of Michigan, Ann Arbor, MI, USA
    Exp Dermatol 11:406-12. 2002
    ..gene expression, we identified an inverse correlation between expression and DNA methylation for two EDC genes (S100A2 and S00A6) in human keratinocytes and fibroblasts...
  80. ncbi Expression profiling of primary non-small cell lung cancer for target identification
    Jim Heighway
    Target Identification Group, Roy Castle International Centre for Lung Cancer Research, University of Liverpool, 200 London Road, Liverpool L3 9TA, UK
    Oncogene 21:7749-63. 2002
    ..genes, previously designated as potential tumour suppressors in breast (maspin) and lung and breast (S100A2) cancers, were analysed more extensively and demonstrate the effectiveness of this approach in identifying ..
  81. ncbi S100A6 protein expression is different in Spitz nevi and melanomas
    Adriana Ribe
    Dermatopathology Division, Department of Pathology, New York Presbyterian Hospital Cornell University Weill Medical College, New York, New York, USA
    Mod Pathol 16:505-11. 2003
    ..Normal intraepidermal melanocytes were negative. The melanocytic cells in these three entities did not express S100A2, S100A8/A9 or A12...
  82. ncbi Immunolocalization of S100A2 calcium-binding protein in cartilage and bone cells
    N Balmain
    Laboratoire de Nutrition et de Sécurité Alimentaire INRA, F 78350 Jouy en Josas, France
    Cell Mol Biol (Noisy-le-grand) 49:485-6. 2003
    b>S100A2 protein, a Ca2+ binding protein, was investigated by immunocytochemistry in the epiphyseal cartilage and bone cells of growing rats, and in primary cultures of osteoblasts...
  83. pmc S100A7 and the progression of breast cancer
    Ethan D Emberley
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Breast Cancer Res 6:153-9. 2004
    ..Molecular analysis of breast tumors has revealed that several S100s, including S100A2, S100A4 and S100A7, exhibit altered expression levels during breast tumorigenesis and/or progression...
  84. ncbi Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers
    S S Cross
    Academic Unit of Pathology, Division of Genomic Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Histopathology 46:256-69. 2005
    ..S100A6, S100A8, S100A9 and S100A11 have all been suggested to have potential roles in carcinogenesis and tumour progression but their expression has not been described in a wide range of human tissues and tumours...
  85. ncbi Expression of S100A2 and S100A6 in thyroid carcinomas
    Y Ito
    Kuma Hospital, Chuo Ku, Kobe, Japan
    Histopathology 46:569-75. 2005
    S100 calcium-binding proteins are known to play multiple roles in carcinoma development. In this study, we focused on two kinds of these proteins, S100A2 and S100A6, and investigated their expression in thyroid neoplasms.
  86. ncbi Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients
    Kim Nielsen
    Department of Ophthalmology, Aarhus University Hospital, Denmark
    Cornea 24:661-8. 2005
    This investigation was designed to determine whether the five genes, CLC, DSG3, EMP3, S100A2 and SLPI, are differentially expressed in keratoconus, as indicated from another study.
  87. ncbi Establishment of an immortalized cell line from a precancerous lesion of lung adenocarcinoma, and genes highly expressed in the early stages of lung adenocarcinoma development
    Aki Shimada
    Department of Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba shi, Ibaraki 305 8575, Japan
    Cancer Sci 96:668-75. 2005
    ..32%) of them encoded tumor-associated calcium signal transducer 2 (TACSTD2) and S100 calcium binding protein A2 (S100A2), respectively. The high transcription of TACSTD2 and S100A2 in PL16T was confirmed by in situ hybridization...
  88. ncbi Prognostic and diagnostic relevance of hnRNP A2/B1, hnRNP B1 and S100 A2 in non-small cell lung cancer
    Veronika F E Zech
    Department of Internal Medicine, Division of General Internal Medicine, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Cancer Detect Prev 30:395-402. 2006
    ..Since previous studies using paraffin-embedded tissues indicated a high potential of these markers for diagnosis and screening the present analysis intended to validate these data applying cryostat sections...
  89. pmc Purification and crystallization of the human EF-hand tumour suppressor protein S100A2
    Michael Koch
    Fachbereich Biologie, Universitat Konstanz, Postfach M665, Universitatsstrasse 10, 78457 Konstanz, Germany
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:1120-3. 2006
    b>S100A2 is a Ca(2+)-binding EF-hand protein that is mainly localized in the nucleus. There, it acts as a tumour suppressor by binding and activating p53. Wild-type S100A2 and a S100A2 variant lacking cysteines have been purified...
  90. ncbi Decreased expression of gene cluster at chromosome 1q21 defines molecular subgroups of chemoradiotherapy response in esophageal cancers
    Madan G Luthra
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77054, USA
    Clin Cancer Res 13:912-9. 2007
    ..We previously noted an association between decreased expression of epidermal differentiation complex (EDC) genes S100A2 and SPRR3 at chromosome 1q21 and CTXRT resistance...
  91. ncbi Down-regulation of insulin-like growth factor binding protein-5 (IGFBP-5): novel marker for cervical carcinogenesis
    Takashi Miyatake
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 1 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Int J Cancer 120:2068-77. 2007
    ..Real-time RT-PCR analysis was conducted on a selected subset of these genes (S100A2, GPC4, p72, IGFBP-5, TRIM2 and NAB2) for 14 additional SCCs and 10 normal epithelia...
  92. ncbi A review of the S100 proteins in cancer
    I Salama
    Newham University Hospital, London, UK
    Eur J Surg Oncol 34:357-64. 2008
    ..This review summarises the biological and clinical relevance of these proteins in relation to different tumour types...
  93. pmc Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma
    J C Lindsey
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Br J Cancer 97:267-74. 2007
    ..Four family members (S100A2, S100A4, S100A6 and S100A10) demonstrated evidence of upregulated expression in multiple medulloblastoma cell ..
  94. ncbi S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer
    Patrick C Mahon
    Centre for Molecular Oncology, Institute of Cancer and the Cancer Research UK Clinical Centre, Barts and the London School of Medicine, London, United Kingdom
    Cancer Res 67:6786-95. 2007
    ..This analysis identified several S100 family proteins, of which two, S100A2 and S100A4, showed in vitro the ability to repress exogenous BNIP3 promoter activity...
  95. ncbi Expression of S100A2 and S100A4 predicts for disease progression and patient survival in bladder cancer
    Kazumasa Matsumoto
    Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Urology 70:602-7. 2007
    To determine the expression patterns and prognostic value of S100A2 and S100A4 in surgical specimens from radical cystectomy for transitional cell carcinoma of the urinary bladder.
  96. ncbi The prognostic value of Stathmin-1, S100A2, and SYK proteins in ER-positive primary breast cancer patients treated with adjuvant tamoxifen monotherapy: an immunohistochemical study
    Rastko Golouh
    Institute of Oncology, Ljubljana, Slovenia
    Breast Cancer Res Treat 110:317-26. 2008
    We recently found that DNA methylation of S100A2, spleen tyrosine kinase (SYK), and Stathmin-1 (STMN1) correlates with response to tamoxifen therapy in metastatic breast cancer...
  97. ncbi Over-expression of S100A2 in pancreatic cancer correlates with progression and poor prognosis
    K Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pathol 213:275-82. 2007
    Controversy exists regarding the clinical significance of S100A2 in the progression of tumours. In pancreatic cancer, little is known about the role of S100A2...
  98. ncbi Large intra- and inter-individual variability of genes expression levels limits potential predictive value of molecular diagnosis of dysplasia in Barrett's esophagus
    Ewa E Hennig
    Department of Gastroenterology and Hepatology, Medical Center for Postgraduate Education at the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    J Mol Med (Berl) 86:233-42. 2008
    ..from Barrett's esophagus without dysplasia to Barrett's esophagus with high-grade dysplasia, only a decrease in S100A2 mRNA levels was statistically significant (P<0.05)...
  99. doi Crystal structure of Ca2+ -free S100A2 at 1.6-A resolution
    Michael Koch
    Fachbereich Biologie, Universitat Konstanz, Postfach M665, Universitatsstrasse 10, 78457 Konstanz, Germany
    J Mol Biol 378:933-42. 2008
    b>S100A2 is an EF hand-containing Ca(2+)-binding protein of the family of S100 proteins. The protein is localized exclusively in the nucleus and is involved in cell cycle regulation...
  100. doi Differential expression of S100 protein subtypes in malignant melanoma, and benign and malignant peripheral nerve sheath tumors
    Daisuke Nonaka
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Cutan Pathol 35:1014-9. 2008
    ..S100 family of proteins consists of over 20 members. We report on S100 subtypes in malignant melanomas (MMs), and BPNSTs and MPNSTs to investigate differential expression...
  101. doi Frequent polymorphic variations but rare tumour specific mutations of the S100A2 on 1q21 in non-small cell lung cancer
    Mojca Strazisar
    Department of Molecular Genetics, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia
    Lung Cancer 63:354-9. 2009
    Contrary to the recent hypothesis that S100A2 is a tumour suppressor, no somatic mutations have yet been identified...

Research Grants5

  1. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
    ..In Specific Aim 1, they clone, express, and generate antibodies to the remaining keratinocyte S100 proteins, S100A2, S100A4, S100A6, S100A8, and S100A9...
  2. The Structure and Function of S100 Proteins
    DAVID JOSEPH WEBER; Fiscal Year: 2010
    ..e. for S100A1, S100A2, and S100A4) will identify the molecular determinants that provide specificity in S100-target protein complexes;..
  3. Organ Culture of Basal Cell Carcinoma
    James Elder; Fiscal Year: 2002
    ....
  4. Dendritic Cell Immunotherapy for Cervical Cancer
    Alessandro Santin; Fiscal Year: 2004
    ..This study will determine whether E7 antigen-loaded autologous DC vaccination offers the potential of therapeutic benefit for patients with HPV16 or HPV18-associated cervical cancer. ..
  5. Amphiregulin in Psoriatic Epidermal Hyperplasia
    JAMES TILFORD ELDER; Fiscal Year: 2010
    ..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..