SEMA6A

Summary

Gene Symbol: SEMA6A
Description: semaphorin 6A
Alias: HT018, SEMA, SEMA6A1, SEMAQ, VIA, semaphorin-6A, SEMA6A-1, sema VIa, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A, semaphorin 6A-1, semaphorin VIA
Species: human

Top Publications

  1. ncbi The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain
    A Klostermann
    MPI of Psychiatry, Independent Research Group Neurodegeneration, Kraepelinstrasse 2, 80804 Munich, Germany
    J Biol Chem 275:39647-53. 2000
  2. doi A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order
    Adaikalavan Ramasamy
    Respiratory Epidemiology and Public Health, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 128:996-1005. 2011
  3. pmc Substrate Stiffness Affects Human Keratinocyte Colony Formation
    Hoda Zarkoob
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA
    Cell Mol Bioeng 8:32-50. 2015
  4. pmc Spontaneous Neurotransmitter Release Shapes Dendritic Arbors via Long-Range Activation of NMDA Receptors
    Laura C Andreae
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK Electronic address
    Cell Rep . 2015
  5. doi Surface Trafficking of APP and BACE in Live Cells
    Anna Bauereiss
    Department of Psychiatry and Psychotherapy, Friedrich Alexander Universität Erlangen Nürnberg FAU, Schwabachanlage 6, 91054, Erlangen, Germany
    Traffic 16:655-75. 2015
  6. pmc A direct GABAergic output from the basal ganglia to frontal cortex
    Arpiar Saunders
    Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 521:85-9. 2015
  7. pmc The RhoGEF DOCK10 is essential for dendritic spine morphogenesis
    Fanny Jaudon
    Centre de Recherche en Biochimie Macromoleculaire, CNRS UMR 5237, Universite de Montpellier, 34293 Montpellier, France
    Mol Biol Cell 26:2112-27. 2015
  8. pmc Collybistin binds and inhibits mTORC1 signaling: a potential novel mechanism contributing to intellectual disability and autism
    Camila Oliveira Freitas Machado
    Hospital Israelita Albert Einstein, Instituto de Ensino e Pesquisa, Sao Paulo, Brazil
    Eur J Hum Genet 24:59-65. 2016
  9. pmc Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways
    F Farzana
    Department of Functional Genomics, Centre for Neurogenomics and Cognitive Research CNCR, Neuroscience Campus Amsterdam, VU Medical Centre, VU University Amsterdam, 1081HV, Amsterdam, The Netherlands
    Mol Neurobiol 53:2112-23. 2016
  10. doi Impact of preconditioning with retinoic acid during early development on morphological and functional characteristics of human induced pluripotent stem cell-derived neurons
    Sandra Horschitz
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, Germany
    Stem Cell Res 15:30-41. 2015

Research Grants

  1. Watching a vertebrate brain learn and behave in a virtual environment
    Florian Engert; Fiscal Year: 2011
  2. Florian Engert; Fiscal Year: 2015
  3. RAYMOND CHARLES KOEHLER; Fiscal Year: 2016
  4. Rapid ischemic tolerance: Synaptic re-organization and reduced excitotoxicity
    Robert Meller; Fiscal Year: 2012
  5. Molecular mechanisms of neural plasticity in drug addiction
    LAURA NICOLE SMITH; Fiscal Year: 2010
  6. Kinase/Phosphatase-mediated Mitochondrial Restructuring in Neuroprotection
    Stefan Strack; Fiscal Year: 2012
  7. Paco S Herson; Fiscal Year: 2016
  8. Stefan Strack; Fiscal Year: 2016
  9. GABA-B Receptor Modulation of Calcium Currents
    Michelle Mynlieff; Fiscal Year: 2010
  10. LRP AND ALZHEIMER'S DISEASE
    Bradley T Hyman; Fiscal Year: 2011

Detail Information

Publications21498 found, 100 shown here

  1. ncbi The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain
    A Klostermann
    MPI of Psychiatry, Independent Research Group Neurodegeneration, Kraepelinstrasse 2, 80804 Munich, Germany
    J Biol Chem 275:39647-53. 2000
    ..Here, we report the identification of two novel transmembranous human and murine semaphorins, (HSA)SEMA6A-1 and (MMU)Sema6A-1...
  2. doi A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order
    Adaikalavan Ramasamy
    Respiratory Epidemiology and Public Health, Imperial College, London, United Kingdom
    J Allergy Clin Immunol 128:996-1005. 2011
    ..The underlying genetic variants have not been studied comprehensively. There is overwhelming evidence that those who have older siblings have less AR, although the mechanism for this remains unclear...
  3. pmc Substrate Stiffness Affects Human Keratinocyte Colony Formation
    Hoda Zarkoob
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA
    Cell Mol Bioeng 8:32-50. 2015
    ..keratinocyte colony formation observed in our experiments could be due to cell-cell mechanical signaling generated via local substrate deformations that appear to be correlated with the increased expression of β4 integrin within ..
  4. pmc Spontaneous Neurotransmitter Release Shapes Dendritic Arbors via Long-Range Activation of NMDA Receptors
    Laura C Andreae
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK Electronic address
    Cell Rep . 2015
    ..Blockade of NMDA signaling during this early period of spontaneous vesicle cycling leads to a reduction in dendritic arbor complexity, indicating an important role for early spontaneous release in dendritic arbor growth...
  5. doi Surface Trafficking of APP and BACE in Live Cells
    Anna Bauereiss
    Department of Psychiatry and Psychotherapy, Friedrich Alexander Universität Erlangen Nürnberg FAU, Schwabachanlage 6, 91054, Erlangen, Germany
    Traffic 16:655-75. 2015
    Amyloid-β (Aβ)-peptide, the major constituent of the plaques that develop during Alzheimer's disease, is generated via the cleavage of Aβ precursor protein (APP) by β-site APP-cleaving enzyme (BACE)...
  6. pmc A direct GABAergic output from the basal ganglia to frontal cortex
    Arpiar Saunders
    Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 521:85-9. 2015
    ..Current models postulate that the basal ganglia modulate cerebral cortex indirectly via an inhibitory output to thalamus, bidirectionally controlled by direct- and indirect-pathway striatal projection ..
  7. pmc The RhoGEF DOCK10 is essential for dendritic spine morphogenesis
    Fanny Jaudon
    Centre de Recherche en Biochimie Macromoleculaire, CNRS UMR 5237, Universite de Montpellier, 34293 Montpellier, France
    Mol Biol Cell 26:2112-27. 2015
    ..Our global approach thus identifies an unprecedented function for DOCK10 as a novel regulator of dendritic spine morphogenesis via a Cdc42-mediated pathway.
  8. pmc Collybistin binds and inhibits mTORC1 signaling: a potential novel mechanism contributing to intellectual disability and autism
    Camila Oliveira Freitas Machado
    Hospital Israelita Albert Einstein, Instituto de Ensino e Pesquisa, Sao Paulo, Brazil
    Eur J Hum Genet 24:59-65. 2016
    Protein synthesis regulation via mammalian target of rapamycin complex 1 (mTORC1) signaling pathway has key roles in neural development and function, and its dysregulation is involved in neurodevelopmental disorders associated with ..
  9. pmc Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways
    F Farzana
    Department of Functional Genomics, Centre for Neurogenomics and Cognitive Research CNCR, Neuroscience Campus Amsterdam, VU Medical Centre, VU University Amsterdam, 1081HV, Amsterdam, The Netherlands
    Mol Neurobiol 53:2112-23. 2016
    ..suggest that the PKA-binding domain is not essential for Nbea's role in receptor targeting and that Nbea targets glutamate and GABA receptors to the synapse via distinct molecular pathways by interacting with specific effector proteins.
  10. doi Impact of preconditioning with retinoic acid during early development on morphological and functional characteristics of human induced pluripotent stem cell-derived neurons
    Sandra Horschitz
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, Germany
    Stem Cell Res 15:30-41. 2015
    ..The directed differentiation of hiPSCs via the generation of a self-renewable neuronal precursor cell line allows the standardization of defined ..
  11. ncbi Comparative immunological and chemical analysis of lipids and carotenoids of the D1-peptide and of the light-harvesting-complex of photosystem II of Nicotiana tabacum
    A Gasser
    , , , Germany
    Z Naturforsch C 54:199-208. 1999
    ..of boiling methanol and chloroform and subsequent HPLC-chromatography showed that in the D1-peptide isolated via SDS-polyacrylamide gel electrophoresis, monogalactolipids, phosphatidylglycerol and sulfolipid molecules are bound ..
  12. pmc Effects of high calcium diet on arterial smooth muscle function and electrolyte balance in mineralocorticoid-salt hypertensive rats
    P Arvola
    Department of Biomedical Sciences, University of Tampere, Finland
    Br J Pharmacol 108:948-58. 1993
    ..The rate of aortic low Na+ contractions (evaluating Ca2+ influx via Na+, Ca2+ exchange), as well as that of subsequent relaxations was slower in DOC-NaCl-treated rats than in controls,..
  13. ncbi Superoxide-dependent and -independent nitrite formation from hydroxylamine: inhibition by plant extracts
    U Rohnert
    , , Freising Weihenstephan, Germany
    Z Naturforsch C 53:241-9. 1998
    ..The formation of OH (Fenton)-type radicals is catalyzed by enzymes such as xanthine oxidase (XOD) via one-electron reduction of molecular oxygen producing superoxide radical anions (O2)...
  14. pmc Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo
    Y Hirayama
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 108:844-51. 1993
    ..We conclude that in guinea-pig airways, plasma leakage induced by endogenous tachykinins is mediated predominantly via NK1-receptors, whereas bronchoconstriction is mediated predominantly via NK2-receptors...
  15. pmc Modulation by nicotinamide adenine dinucleotide of sympathetic and sensory-motor neurotransmission via P1-purinoceptors in the rat mesenteric arterial bed
    V Ralevic
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 114:1541-8. 1995
    ..concluded that NAD can act as a modulator of sympathetic and sensory-motor transmission in rat mesenteric arteries via P1-purinoceptors possibly via direct actions but with a contribution of adenosine formed following breakdown of NAD ..
  16. ncbi Development and pharmacology of fluvastatin
    L A Jokubaitis
    Cardiovascular Clinical Research, Sandoz Research Institute, East Hanover, NJ 07936, USA
    Br J Clin Pract Suppl 77:11-5. 1996
    ..Some 95% of a single dosage of fluvastatin is excreted via the biliary route, with less than 2% of this being the parent compound...
  17. ncbi [Infections which humans in the household transmit to dogs and cats]
    A Mayr
    , Infektions und Seuchenmedizin, ,
    Zentralbl Bakteriol Mikrobiol Hyg B 187:508-26. 1989
    ..Listeria, salmonella, campylobacteria, toxoplasma, fungi, yeasts and viruses are transmitted via feed...
  18. pmc Effect of inhibition of nitric oxide synthesis on the uptake of LDL and fibrinogen by arterial walls and other organs of the rat
    L E Cardona Sanclemente
    Pathopharmacology Unit, William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1490-4. 1995
    ..2. The uptake of LDL and fibrinogen, labelled respectively with 125I or 131I via the adduct tyramine cellobiose ([125I]TC-LDL and [131I]TC-fibrinogen), were compared in aortic walls, heart, ..
  19. ncbi [Work of breathing in differentiation of various forms of sleep-related breathing disorders]
    T Barchfeld
    Krankenhaus Kloster Grafschaft, , Schlaf- und Beatmungsmedizin, Schmallenberg Grafschaft
    Pneumologie 51:931-5. 1997
    ..oesophageal catheter; at the same time, the minute ventilation (VE) and the breathing frequency (fb) were measured via a pneumotachygraph. The area under the pressure-volume loop was correlated to WOB...
  20. ncbi NGF-resistant PC12 cell death induced by arachidonic acid is accompanied by a decrease of active PKC zeta and nuclear factor kappa B
    N J Macdonald
    Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch at Galveston, USA
    J Neurosci Res 57:219-26. 1999
    ..NGF acts via binding to a specific tyrosine kinase receptor (TrkA)...
  21. ncbi Metabolism of trimethylamines in kelp bass (Paralabrax clathratus) and marine and freshwater pink salmon (Oncorhynchus gorbuscha)
    R P Charest
    Department of Biological Sciences, University of Southern California, Los Angeles 90089
    J Comp Physiol B 158:609-19. 1988
    ..up into a sequestered pool from which it is slowly released, oxidized to TMAO in the liver, and then transported via the circulation to the muscle mass. The location of this proposed sequestered TMA pool was not determined...
  22. pmc Predominance of endothelinA (ETA) receptors in ovine airway smooth muscle and their mediation of ET-1-induced contraction
    R G Goldie
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 112:749-56. 1994
    ..Contraction of parenchymal lung strip preparations to ET-1 was mediated via non-ETB receptors, presumably ETA receptors, with contributions to this response perhaps coming from airway and ..
  23. ncbi Cholinergic transmission via central synapses in the locust nervous system
    S Gauglitz
    Freie Universitat Berlin, Institut fur Biologie, Neurobiologie, Germany
    J Comp Physiol A 187:825-36. 2001
    ..Glutamate also inhibits wind elicited A4I1 responses. Although attempts were made to further characterize the receptor involved, tested substances such as kainic acid, glycine, CNQX or GDEE had no effect...
  24. pmc Endogenous tachykinins facilitate transmission through parasympathetic ganglia in guinea-pig trachea
    N Watson
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 109:751-9. 1993
    ..either by (i) pre-ganglionic vagus nerve stimulation (PGS), (ii) stimulation of postganglionic intramural nerves via transmural stimulating electrodes (TMS) in the presence of ganglion-blocking concentrations of hexamethonium and (..
  25. ncbi Selective translocation of non-conventional protein kinase C isoenzymes by gonadotropin-releasing hormone (GnRH) in the gonadotrope-derived alpha T3-1 cell line
    M Kratzmeier
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    Mol Cell Endocrinol 118:103-11. 1996
    Gonadotropin-releasing hormone acts via G-protein coupled receptors to stimulate polyphosphoinositide-specific phospholipase C (PIC) with consequent elevation of cytosolic Ca2+ and activation of protein kinase C (PKC)...
  26. pmc The effect of cyclic AMP elevating agents on bradykinin- and carbachol-induced signal transduction in canine cultured tracheal smooth muscle cells
    C M Yang
    Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
    Br J Pharmacol 112:781-8. 1994
    ..The BK-induced responses were mediated via a G protein which was not inhibited by CTX or pertussis toxin treatment. 2...
  27. pmc Stimulation of human umbilical vein endothelial cell proliferation by A2-adenosine and beta 2-adrenoceptors
    V Sexl
    Institute of Pharmacology, University of Vienna, Austria
    Br J Pharmacol 114:1577-86. 1995
    ..We therefore conclude that both receptors stimulate endothelial cell proliferation via a common signal transduction pathway. 5...
  28. ncbi Hepatocyte growth factor/scatter factor in the eye
    I Grierson
    Unit of Ophthalmology, Department of Medicine, University of Liverpool, Duncan Building, L69 3GA, Liverpool, UK
    Prog Retin Eye Res 19:779-802. 2000
    ..HGF/SF is synthesised by mesenchymally derived cells and targets and signals epithelial cells in a paracrine manner via their c-Met surface receptor...
  29. pmc Differential effects of NGF and BDNF on axotomy-induced changes in GABA(A)-receptor-mediated conductance and sodium currents in cutaneous afferent neurons
    A A Oyelese
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurophysiol 78:31-42. 1997
    ..Ringer (vehicle) solution was delivered in vivo directly to the transected sciatic nerve stump in axotomized rats via an osmotic pump. Recordings were obtained from neurons 5-24 h after culture...
  30. pmc Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways
    K T Tamai
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    Mol Cell Biol 14:8155-65. 1994
    ..cerevisiae HSF responds to multiple, distinct stimuli to activate yeast metallothionein gene transcription and that these stimuli elicit responses through nonidentical, genetically separable signalling pathways...
  31. pmc Differential changes of adrenoceptor- and muscarinic receptor-linked prostacyclin synthesis by the aorta and urinary bladder of the diabetic rat
    J Y Jeremy
    Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, University of London
    Br J Pharmacol 108:1131-6. 1993
    ..Signal transduction systems were studied via stimulation of PGI2 synthesis with phorbol ester dibutyrate (PDBU; a protein kinase C activator [PKC]), Ca2+ ..
  32. ncbi The relationship of tamoxifen with dementia, depression, and dependence in activities of daily living in elderly nursing home residents
    B Breuer
    Medical Research Department, The Jewish Home and Hospital, New York, NY 10025, USA
    Women Health 31:71-85. 2000
    ..SETTING: New York State long-term care facilities. DESIGN: Cross-sectional study via secondary analysis of 1,385 matched sets of residents...
  33. pmc Vascular mode of action of kinin B1 receptors and development of a cellular model for the investigation of these receptors
    L Levesque
    , , Canada
    Br J Pharmacol 109:1254-62. 1993
    1. Kinins exert a contractile effect on rabbit aortic rings via the stimulation of B1 receptors. Des-Arg9-bradykinin (BK) is more potent than BK on this receptor type...
  34. pmc Autoregulation of enterochromaffin-like cell histamine secretion via the histamine 3 receptor subtype
    M Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520-8062, USA
    Yale J Biol Med 69:9-19. 1996
    ..We have proposed that histamine may regulate its own synthesis and release via an autocrine mechanism...
  35. ncbi Alpha 2-macroglobulin-mediated degradation of amyloid beta 1--42: a mechanism to enhance amyloid beta catabolism
    D Lauer
    Institute of Biochemistry, University of Leipzig, Liebigstrasse 16, 04103 Leipzig, Germany
    Exp Neurol 167:385-92. 2001
    ..There are indications that soluble A beta present in circulation can cross the blood-brain barrier via transcytosis mediated by brain capillary endothelial cells...
  36. pmc Muscarinic (M1) receptor-mediated inhibition of K(+)-evoked [3H]-noradrenaline release from human neuroblastoma (SH-SY5Y) cells via inhibition of L- and N-type Ca2+ channels
    R L McDonald
    Department of Pharmacology, University of Leeds
    Br J Pharmacol 113:621-7. 1994
    ..Activation of muscarinic Ml receptors can inhibit release via a pertussis toxin-insensitive mechanism which involves non-selective inhibition of L- and N-type Ca2+ channels...
  37. ncbi Repression of the rat steroidogenic acute regulatory (StAR) protein gene by PGF2alpha is modulated by the negative transcription factor DAX-1
    T W Sandhoff
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, USA
    Endocrine 10:83-91. 1999
    ..Consistent with the possibility that PGF2alpha regulates ovarian StAR expression via DAX-1, Western blot analysis indicated a three- and fivefold increase in rat ovarian DAX-1 levels at 2 and 4 h ..
  38. pmc Calcium signaling mechanisms in the gastric parietal cell
    C S Chew
    Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia 30310-1495
    Yale J Biol Med 65:561-76; discussion 621-3. 1992
    ..In vitro studies have shown that histamine acts mainly via a cAMP-dependent pathway, and acetylcholine acts via a calcium-dependent pathway...
  39. ncbi [Ionic perturbations produced by a non-laminar flow in vascular smooth muscle cells in culture. Protection by cicletanine via a cyclo-oxygenase metabolite]
    C Rosati
    INSERM U7/CNRS UA 318, , Paris
    Arch Mal Coeur Vaiss 82:41-4. 1989
    ..Sodium nitroprusside, a compound able to stimulate calcium entry in the sarcoplasmic reticulum via cyclic GMP, was also able to protect vascular cells (although it acted at higher concentrations than cicletanine)...
  40. ncbi Montelukast in the prophylaxis of migraine: a potential role for leukotriene modifiers
    F Sheftell
    New England Center for Headache, Stamford, CT 06902, USA
    Headache 40:158-63. 2000
    ..metabolism of arachidonic acid, with prostaglandins coming off the cyclooxygenase pathway and leukotrienes derived via the enzyme 5-lipoxygenase. Both prostaglandins and leukotrienes mediate inflammatory responses...
  41. ncbi Predicting the outcomes of electrophysiologic studies of patients with unexplained syncope: preliminary validation of a derived model
    M Linzer
    Department of Medicine, Duke University Medical Center, Durham, North Carolina
    J Gen Intern Med 6:113-20. 1991
    ..from the history, the physical examination, electrocardiography (ECG), and Holter monitoring were analyzed via two multivariable predictive modeling strategies (ordinal logistic regression and recursive partitioning) for their ..
  42. ncbi Biochemical comparisons of the normal and oncogenic forms of insect cell-expressed neu tyrosine kinases
    P M Guy
    Department of Biochemistry, Molecular, and Cell Biology, Cornell University, Ithaca, New York 14853-6401
    J Biol Chem 267:13851-6. 1992
    ..Using three different forms of neu expressed in insect cells via baculovirus infection, we have examined the biochemical differences between the normal and transforming forms of ..
  43. ncbi Renal function in one-kidney, one-clip hypertension and low renin essential hypertension
    J E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505
    Am J Hypertens 4:523S-533S. 1991
    ..homeostasis mechanisms that initially raise cardiac output and later elevate total peripheral vascular resistance via autoregulatory adjustments...
  44. ncbi Sleep apnea and quality of life
    E H Yang
    Johns Hopkins Hospital Department of Medicine, USA
    Sleep 23:535-41. 2000
    ..Health history and demographic data were obtained via structured interview and medical record review...
  45. pmc Effects of tumor necrosis factor, endothelin and nitric oxide on hyperdynamic circulation of rats with acute and chronic portal hypertension
    Ji Jian Wang
    Department of General Surgery, Second Affiliated Hospital, Chongqing University of Medical Sciences, 74 Linjing Road, Chongqing 400010, China
    World J Gastroenterol 10:689-93. 2004
    ..To evaluate the effect of tumor necrosis factor (TNF), endothelin (ET) and nitric oxide (NO) on hyperdynamic circulation (HC) of rats with acute and chronic portal hypertension (PHT)...
  46. pmc The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene
    C Schuller
    Vienna Biocenter, Institut fur Biochemie und Molekulare Zellbiologie, Universitat Wien, Austria
    EMBO J 13:4382-9. 1994
    ..g. HSP104) are regulated like CTT1. Furthermore, catalase T was shown to be important for viability under severe osmotic stress, and heat shock was demonstrated to provide cross-protection against osmotic stress...
  47. pmc Endotoxin impairs the response of rabbit mesenteric artery to electrical stimulation via a prejunctional mechanism
    S Tomikawa
    Department of Pharmacology, Kanagawa Dental College, Japan
    Br J Pharmacol 107:826-32. 1992
    ..results suggest that treatment of rabbits with LPS inhibits noradrenaline release from sympathetic nerve endings via increased sensitivity of both prejunctional inhibitory muscarinic receptors and x2-adrenoceptors in mesenteric ..
  48. ncbi Biochemical basis of hepatocellular injury
    G L Kedderis
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:77-83. 1996
    ..concentration of the toxicant (parent compound or metabolite) delivered to the hepatocytes across the liver acinus via blood flow...
  49. pmc The biphasic response of rat vesical smooth muscle to ATP
    C Bolego
    Institute of Pharmacological Sciences, University of Milan, Italy
    Br J Pharmacol 114:1557-62. 1995
    1. Adenosine-5'-triphosphate (ATP) is known to exert a variety of biological effects via the activation of either ionotropic P2x- or G-protein coupled P2Y-purinoceptor subtypes...
  50. ncbi A phase I study of recombinant interleukin 2 in melanoma patients. Toxicity and clinical effects
    R Marolda
    Division of Surgical Oncology "B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 73:575-84. 1987
    ..doses from 100 micrograms/m2 to 800 micrograms/m2 were administered thrice a day with bolus injections given via a peripheral venous catheter for up to a maximum of 7 days...
  51. pmc Intracerebral microdialysis combined with recording of extracellular field potential: a novel method for investigation of depolarizing drugs in vivo
    T P Obrenovitch
    Gough Cooper Department of Neurological Surgery, Institute of Neurology, London
    Br J Pharmacol 113:1295-302. 1994
    ..Increasing concentrations of excitatory amino acids were applied for 2 min via the microdialysis probe, and the extracellular direct current (d.c...
  52. ncbi Effects of deamino-8-D-arginin vasopressin on blood loss and coagulation factors in scoliosis surgery. A double-blind randomized clinical trial
    A Alanay
    Department of Orthopaedics and Traumatology, Hacettepe University, Ankara, Turkey
    Spine (Phila Pa 1976) 24:877-82. 1999
    ..has any effect on reducing blood loss in spinal surgery, to identify the probable mechanisms of effectiveness via blood coagulation factors, and to outline any adverse effect associated with the use of deamino-8-D-arginin ..
  53. ncbi Histamine blocks interleukin 2 (IL-2) gene expression and regulates IL-2 receptor expression
    A R Rezai
    Department of Microbiology and Immunology, UCLA School of Medicine 90024
    Immunopharmacol Immunotoxicol 12:345-62. 1990
    ..This inhibition was mediated via the H2 receptor since cimetidine, a known H2 antagonist, removed the inhibition, whereas the addition of the H1 ..
  54. ncbi Stimulation of chemosensitive afferents from multifidus muscle does not sensitize multifidus muscle spindles to vertebral loads in the lumbar spine of the cat
    Y M Kang
    Palmer Center for Chiropractic Research, Davenport
    Spine (Phila Pa 1976) 26:1528-36. 2001
    ..afferents sensitive to algesic or inflammatory metabolites increases the stretch sensitivity of muscle spindles via a reflex pathway involving gamma-motoneurons...
  55. ncbi [Temporary caval filter allowing diagnosis and fibrinolytic therapy in patients suspect of massive pulmonary embolism]
    C Thery
    Service de soins intensifs, Hopital Cardiologique de Lille
    Arch Mal Coeur Vaiss 84:525-30. 1991
    ..A removable vena cava filter is rapidly introduced percutaneously via a brachial, femoral or jugular vein, and opened in the inferior vena cava...
  56. pmc In vivo and in vitro evidence of altered nitric oxide metabolism in the spontaneously diabetic, insulin-dependent BB/Edinburgh rat
    R M Lindsay
    Metabolic Unit, Western General Hospitals NHS Trust, Edinburgh
    Br J Pharmacol 120:1-6. 1997
    ..2. Mean arterial pressure (measured directly via indwelling carotid arterial cannulae) was not significantly different between non-diabetic (116 +/- 3 mmHg; n = 10) ..
  57. ncbi Intrahepatic chemotherapy with floxuridine, leucovorin and dexamethasone in continuous infusion and mitomycin-C bolus in unresectable hepatic metastases from colorectal cancer: a phase II study
    M Bertuccelli
    Sezione di Oncologia Medica, Ospedale di Livorno, Italy
    Tumori 85:473-7. 1999
    ..5 mg/m2/day) + dexamethasone (20 mg on days 1 to 14) and bolus mitomycin C (10 mg/m2 on day 1) via the hepatic artery. Cycles were administered every four weeks...
  58. ncbi Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2/hydroxyapatite-tricalcium phosphate after laminectomy in the nonhuman primate
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, USA
    Spine (Phila Pa 1976) 24:1179-85. 1999
    ..adult rhesus monkeys underwent a laminectomy at L4-L5 followed by bilateral intertransverse process arthrodesis via the same midline incision (n = 16) or a minimally invasive video-assisted posterolateral approach (n = 5)...
  59. pmc Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators
    D T Walsh
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 114:1343-50. 1995
    ..6. These results suggest that SP-induced inflammatory events may be mediated via two mechanisms involving NK1 receptor-dependent and independent pathways...
  60. ncbi Molecular and cellular mechanisms used in the acute phase of stimulated steroidogenesis
    M Thomson
    Department of Biological Sciences, University of Western Sydney Nepean, Kingswood, Australia
    Horm Metab Res 30:16-28. 1998
    ..Cholesterol may then translocate from the outer mitochondrial membrane to the inner via sites of contact between the two membranes...
  61. ncbi Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia
    L X Feng
    Department of Cell Biology, Georgetown University Medical Center, Washington, DC. 20007, USA
    J Biol Chem 275:25572-6. 2000
    ..Constitutively active v-AKT highly phosphorylated p70S6K, which was totally inhibited by rapamycin. Thus, SCF/c-kit uses a rapamycin-sensitive PI3-K/AKT/p70S6K/cyclin D3 pathway to promote spermatogonial cell proliferation...
  62. ncbi Induction of colony-stimulating factor(s) after administration of a traditional Chinese medicine, xiao-chai-hu-tang (Japanese name: shosaiko-to)
    K Yonekura
    Traditional Chinese Medicine Research Laboratories, Kanebo Co. Ltd, Osaka, Japan
    Immunopharmacol Immunotoxicol 12:647-67. 1990
    ..A dose-dependent induction of CSF was observed in mice given shosaiko-to via intravenous route as well as via intraperitoneal route...
  63. ncbi The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent
    M Zewail-Foote
    Department of Chemistry and Biochemistry, The University of Texas at Autin, 78712, USA
    Chem Biol 8:1033-49. 2001
    ..Et 743 binds in the minor groove of DNA and alkylates N2 of guanine via a unique mechanism involving catalytic activation...
  64. pmc Mechanism of carbachol-evoked contractions of guinea-pig ileal smooth muscle close to freezing point
    A M Blackwood
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London
    Br J Pharmacol 109:1029-37. 1993
    ..Thus the majority of the activator calcium required for contraction entered the tissue via voltage-dependent calcium channels (VDCs) at both 37 degrees C and 3 degrees C. 4...
  65. ncbi Wolff Award 1996. The actions of valproate and neurosteroids in a model of trigeminal pain
    F M Cutrer
    Department of Neurology, Massachusetts General Hospital, Boston 02129, USA
    Headache 36:579-85. 1996
    ..pretreated with either valproate or allopregnanolone 30 minutes prior to activation of trigeminal afferent fibers via intracisternal injection of the irritant, capsaicin...
  66. pmc Transmission of hepatitis B, hepatitis C and human immunodeficiency viruses through unsafe injections in the developing world: model-based regional estimates
    A Kane
    Trinity College, Duke University, Durham, NC, USA
    Bull World Health Organ 77:801-7. 1999
    ..every year in developing countries, many of them unsafe, and the transmission of certain bloodborne pathogens via this route is thought to be a major public health problem...
  67. ncbi Problems and risks of unsolicited e-mails in patient-physician encounters in travel medicine settings
    A Sing
    , , Munich, Germany
    J Travel Med 8:109-12. 2001
    ..Seeking on-line travel health advice via E-mail for preventive (teleprevention) or diagnostic reasons may become increasingly popular among patients with ..
  68. ncbi The immobilization of glucose oxidase onto radio-frequency plasma-modified poly(etherurethaneurea)
    M J Danilich
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH
    J Biomater Sci Polym Ed 3:195-216. 1992
    ..Active sites for the immobilization were obtained via reduction with aqueous sodium borohydride and activation with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate...
  69. ncbi [Characteristics and predictive value of quality of life in a French cohort of angina patients]
    S M Consoli
    Service de psychologie clinique et psychiatrie de liaison, , 75015 Paris
    Arch Mal Coeur Vaiss 94:1357-66. 2001
    ..QoL was assessed at baseline via a self-administered 12-item general questionnaire, the Short-Form 12 (SF-12), enabling to compute a mental ..
  70. pmc The effect of caffeine on prostaglandin output from the guinea-pig uterus
    E K Naderali
    Department of Pharmacology, University of Edinburgh Medical School
    Br J Pharmacol 113:103-10. 1994
    ..were not prevented by lack of extracellular calcium, ryanodine or ruthenium red (both inhibitors of calcium release via the ryanodine receptor), although the increase in PGF2 alpha output tended to be slower when extracellular calcium ..
  71. pmc SMS 201-995-induced stimulation of gastric acid secretion via the dorsal vagal complex and inhibition via the hypothalamus in anaesthetized rats
    M Yoneda
    CURE Gastroenteric Biology Center, West Los Angeles VA Medical Center, CA 90073, USA
    Br J Pharmacol 116:2303-9. 1995
    ..The site specific pattern of acid responses to SMS 201-995 may be linked to the distribution of receptor subtypes at these sites that convey the different biological actions of somatostatin...
  72. ncbi Isolation, characterization, and substrate specificity of the plasma membrane ATPase of the hlophilic achaeon Haloferax volcanii
    K Steinert
    , , Bundesrepublik Deutschland
    Z Naturforsch C 51:29-39. 1996
    Isolated membranes of the moderate halophilic bacterium Haloferax volcanii are able to hydrolyze ATP via an ATPase, which needs the presence of Mg2+ or Mn2+, high concentrations of NaCl, a pH value of 9, and high temperatures with an ..
  73. ncbi Mechanical strain stimulates a mitogenic response in coronary vascular smooth muscle cells via release of basic fibroblast growth factor
    K Sudhir
    Baker Medical Research Institute, Alfred Hospital, Prahran, Victoria, Australia
    Am J Hypertens 14:1128-34. 2001
    ..Thus, mechanical strain is an important stimulus for growth factor release in coronary VSM cells. The mitogenic response is mediated by release of bFGF...
  74. ncbi ATP- and adenosine-induced relaxation of the smooth muscle of the pig urethra
    Viktoria Werkström
    Department of Clinical and Experimental Pharmacology, Lund University Hospital, Lund, Sweden
    BJU Int 96:1386-91. 2005
    ..role of ATP in nerve-evoked urethral relaxations, as ATP is thought to cause bladder smooth muscle contraction via P2X receptors, whereas relaxation is mediated via G-protein coupled P2Y receptors, and ATP may also induce ..
  75. doi Steroids in the equine oviduct: synthesis, local concentrations and receptor expression
    Hilde Nelis
    Reprod Fertil Dev . 2015
    ..fluid in the oviduct and diffusion of follicular fluid steroids after ovulation; (2) local transfer of steroids via blood or lymph; (3) local synthesis of progesterone in the oviduct, as evidenced by the expression of steroidogenic ..
  76. ncbi Ophidian envenomation strategies and the role of purines
    Steven D Aird
    Laboratório de Toxinas Naturais, Universidade Estadual do Ceara, Avenida Paranjana, 1700, Itaperi, 60740 000, Fortaleza, CE, Brazil
    Toxicon 40:335-93. 2002
    Snake envenomation employs three well integrated strategies: prey immobilization via hypotension, prey immobilization via paralysis, and prey digestion...
  77. ncbi [The role of hydrogen sulfide in acute lung injury during endotoxic shock and its relationship with nitric oxide and carbon monoxide]
    Xin Li Huang
    Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China
    Zhonghua Yi Xue Za Zhi 88:2240-5. 2008
    ..To explore the role of hydrogen sulfide (H2S) in acute lung injury (ALI) during endotoxic shock (ES) and its relationship with nitric oxide (NO) and carbon monoxide (CO)...
  78. doi Seasonal influenza vaccines
    Anthony E Fiore
    Centers for Disease Control and Prevention, 1600 Clifton Rd, NE Atlanta, GA 30333, USA
    Curr Top Microbiol Immunol 333:43-82. 2009
    ..Inactivated influenza vaccines have been available since the 1940s and are administered via intramuscular injection. Inactivated vaccines can be given to anyone six months of age or older...
  79. ncbi Peroxisomal lipid degradation via beta- and alpha-oxidation in mammals
    G P Mannaerts
    Katholieke Universiteit Leuven, Departement Moleculaire Celbiologie, Afdeling Farmacologie, Campus Gasthuisberg O and N, Herestraat 49, B 3000 Leuven, Belgium
    Cell Biochem Biophys 32:73-87. 2000
    ..straight chain acyl-CoAs (including the CoA esters of dicarboxylic fatty acids and eicosanoids) are beta-oxidized via palmitoyl-CoA oxidase, multifunctional protein-1 (which displays 2-enoyl-CoA hydratase and L-3-hydroxyacyl-CoA ..
  80. ncbi Pharmacological characterization of the ergot alkaloid receptor in the salivary gland of the ixodid tick Amblyomma hebraeum
    W Reuben Kaufman
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, T6G 2E9, Canada
    J Exp Biol 209:2525-34. 2006
    ..the family Ixodidae osmoregulate by secreting the excess fluid of the blood meal back into the host's circulation via the salivary glands...
  81. ncbi Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis)
    Jose A Castro
    Centro de Investigaciones Toxicológicas CEITOX CITEFA CONICET, J B de La Salle 4397, Villa Martelli, Pcia de Buenos Aires 1603, Argentina
    Hum Exp Toxicol 25:471-9. 2006
    ..There are different modes of infection: (1) via blood sucking vector insects infected with T...
  82. pmc Potentiation by endothelin-1 of cholinergic nerve-mediated contractions in mouse trachea via activation of ETB receptors
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 114:563-9. 1995
    ..have previously shown that endothelin-1-induced contraction of mouse isolated tracheal smooth muscle was mediated via both ETA and ETB receptors...
  83. ncbi A survey of albuterol administration practices in intubated patients in the neonatal intensive care unit
    Julie Ballard
    Respiratory Care Department, Primary Children s Medical Center, 100 North Medical Drive, Salt Lake City UT 84113 1100, USA
    Respir Care 47:31-8. 2002
    ....
  84. pmc Morphology and connectivity of the small bistratified A8 amacrine cell in the mouse retina
    Sammy C S Lee
    Max Planck Institute for Brain Research, 60438, Frankfurt am Main, Germany
    J Comp Neurol 523:1529-47. 2015
    ..Furthermore, A8 cells are coupled to ON cone bipolar cells by gap junctions, and provide inhibitory input via glycine receptor (GlyR) subunit α1 to OFF cone bipolar cells and to ON A-type ganglion cells...
  85. ncbi Transport of 99mTc-MAG3 via rat renal organic anion transporter 1
    Naoto Shikano
    Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan
    J Nucl Med 45:80-5. 2004
    ..It has been proposed that OAT1 is indirectly involved in PAH uptake via the Na(+) dicarboxylate cotransporter...
  86. ncbi Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens
    John C O'Connor
    DuPont Haskell Laboratory for Health and Environmental Sciences, P O Box 50, Newark, Delaware 19714, USA
    Toxicol Sci 69:92-108. 2002
    ..assay using intact adult male rats has been evaluated for its ability to detect six antiandrogenic compounds via oral administration...
  87. doi Electrodiagnostic medicine skills competency in physical medicine and rehabilitation residents: a method for development and assessment
    David Brown
    UMDNJ Robert Wood Johnson Medical School, Department of Rehabilitation Medicine, JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA
    Am J Phys Med Rehabil 87:654-65. 2008
    ..module, knowledge acquisition and skill attainment were measured in (1) clinical skill in diagnostic procedures via a procedure checklist, (2) diagnosis and ability to design a patient-care management plan via chart simulated ..
  88. ncbi Fluoxetine inhibits calcium-activated currents of salamander rod photoreceptor somata and presynaptic terminals via modulation of intracellular calcium dynamics
    Ernest C Steele
    Neuroscience Institute, Department of Anatomy and Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Mol Vis 11:1200-10. 2005
    ....
  89. doi Comparison of the effects of genistein and zoledronic acid on the bone loss in OPG-deficient mice
    Jianghua Liu
    Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China
    Bone 42:950-9. 2008
    ..In contrast, zoledronic acid could effectively suppress bone resorption and prevent bone loss...
  90. doi Cyanobacterial toxins: a qualitative meta-analysis of concentrations, dosage and effects in freshwater, estuarine and marine biota
    Bas W Ibelings
    Netherlands Institute of Ecology NIOO KNAW Centre for Limnology, Rijksstraatweg 6, 3631 AC, Nieuwersluis, The Netherlands
    Adv Exp Med Biol 619:675-732. 2008
    ..of different cyanobacterial toxins in the tissues of various groups of aquatic biota after exposure via different routes, experimentally in the lab or via natural routes in the environment. The second table (Table A...
  91. doi Treatment of arteriovenous malformations: assessment of 2 techniques--transmandibular curettage versus resection and immediate replantation
    Hossein Behnia
    Department of Oral and Maxillofacial Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    J Oral Maxillofac Surg 66:2557-65. 2008
    This study evaluates 2 surgical methods used at our center for the treatment of mandibular arteriovenous malformations (AVMs): resection with immediate replantation and curettage via proximal transmandibular osteotomy.
  92. ncbi [Phylogeny of gas exchange systems]
    K D Jurgens
    Abteilung Vegetative Physiologie, Medzinische Hochschule, Hannover
    Anasthesiol Intensivmed Notfallmed Schmerzther 37:185-98. 2002
    ..When two convectional gas flows are linked via a diffusional barrier (gas/fluid in the case of the avian lung, fluid/fluid in the case of gills), the directions ..
  93. ncbi Hereditary progressive dystonia with marked diurnal fluctuation
    M Segawa
    Segawa Neurological Clinic for Children, 2 8 Surugadai Kanda, Chiyoda ku, 101 0062, Tokyo, Japan
    Brain Dev 22:S65-80. 2000
    ..This consequently disinhibit the inhibitory efferent pathways and develops postural dystonia via the particular descending pathways to the reticulospinal tract and postural tremor via the ascending pathways to ..
  94. ncbi Physiology of electrosensory lateral line lobe neurons in Gnathonemus petersii
    Y Sugawara
    Department of Physiology, Teikyo University School of Medicine, Kaga 2 11 1, Itabashi ku, Tokyo 173 8605, Japan
    J Exp Biol 202:1301-9. 1999
    ..of the ELL also receive inputs of central origin, including electric organ corollary discharge signals, via parallel fibers and via fibers from the juxtalobar nucleus...
  95. pmc The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase
    Xiaoyong Lei
    Department of Medicine, Mass Spectrometry Resource, and Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 46:10170-85. 2007
    ..apoptosis of INS-1 insulinoma cells due to thapsigargin-induced ER stress was suppressed by inhibition of the group VIA Ca2+-independent phospholipase A2 (iPLA2beta), associated with an increased level of ceramide generation, and that ..
  96. doi Comparison of hairbrush, toothbrush and cotton swab methods for diagnosing asymptomatic dermatophyte scalp carriage
    M Akbaba
    Department of Public Health, Faculty of Medicine, University of Cukurova, Adana, Turkey
    J Eur Acad Dermatol Venereol 22:356-62. 2008
    ..Tinea capitis may also present as a minimal infection, termed carrier state. Anthropophilic dermatophytes (i.e. Trichophyton tonsurans and Trichophyton violaceum) have been generally associated with high rates of asymptomatic carriage...
  97. ncbi Longchain n-3 polyunsaturated fatty acids and microvascular reactivity: observation in the hamster cheek pouch
    Cristiane M S Conde
    Laboratório de Pesquisas em Microcirculação, Pavilhão Reitor Haroldo Lisboa da Cunha, terreo, Universidade do Estado do Rio de Janeiro, Rua Sao Francisco Xavier, 524, 20550 013 Rio de Janeiro RJ, Brazil
    Microvasc Res 73:237-47. 2007
    ..In these microvessels, endothelium-derived relaxing factors (EDRFs) seem to regulate arteriolar diameter [via nitric oxide (NO) and cyclic GMP] and vasomotion [probably via endothelium-derived hyperpolarizing factor (EDHF)]...
  98. ncbi [Primary anterior focus debridement and bone autograft with internal fixation via transperitoneal approach for tuberculosis of lumbosacral junction]
    Lianping Xiao
    Department of Orthopedics, Tianjin Third Central Hospital, Tianjin 300170, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:913-6. 2009
    To evaluate the clinical outcomes of primary anterior focus debridement, bone autograft, and internal fixation via transperitoneal approach in treating tuberculosis of the lumbosacral junction.
  99. pmc Dual-lumen catheters for continuous venovenous hemofiltration: limits for blood delivery via femoral vein access and a potential alternative in an experimental setting in anesthetized pigs
    Juliane K Unger
    Department of Comparative Medicine and Laboratory Animal Sciences, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Crit Care 11:R18. 2007
    ..pathophysiological hemorheology, and/or low cardiac output [CO] are assumed to reduce available blood flow rates via common dual-lumen catheters (except for those with a right atrium catheter tip position) in the critically ill ..
  100. ncbi Cocaine acts on accumbens monoamines and locomotor behavior via a 5-HT2A/2C receptor mechanism as shown by ketanserin: 24-h follow-up studies
    Patricia A Broderick
    Department of Physiology and Pharmacology, CUNY Medical School, New York, NY 10031, USA
    Prog Neuropsychopharmacol Biol Psychiatry 28:547-57. 2004
    It is well known that cocaine's psychomotor stimulant properties derive from enhanced monoamines via synaptic transporter/reuptake inhibition and release mechanisms...
  101. ncbi [Making of the animal model with sterilized testes]
    Feng hua Liu
    Reproductive Medical Center, Third Hospital Affiliated to Guangzhou Medical College, Guangzhou, Guangdong 510150, China
    Zhonghua Nan Ke Xue 13:125-9. 2007
    ..To explore the methods of making an animal model with sterilized testes...

Research Grants141 found, 100 shown here

  1. Watching a vertebrate brain learn and behave in a virtual environment
    Florian Engert; Fiscal Year: 2011
    ..The fish are allowed to control these stimuli via activity in their motor-neurons recorded by a set of external suction electrodes...
  2. Florian Engert; Fiscal Year: 2015
    ..The fish are allowed to control these stimuli via activity in their motor-neurons recorded by a set of external suction electrodes...
  3. RAYMOND CHARLES KOEHLER; Fiscal Year: 2016
    ..dopamine D1 receptors, and striatopallidal neurons are enriched with adenosine A2A receptors, both of which act via PKA and the phosphorylation regulatory protein DARPP-32...
  4. Rapid ischemic tolerance: Synaptic re-organization and reduced excitotoxicity
    Robert Meller; Fiscal Year: 2012
    ..Our prior studies have shown that rapid ischemic tolerance is mediated by selective protein degradation via the ubiquitin-proteasome system...
  5. Molecular mechanisms of neural plasticity in drug addiction
    LAURA NICOLE SMITH; Fiscal Year: 2010
    ..that chronic cocaine exposure regulates spine density in the nucleus accumbens, the brain's reward center, via cyclic-adenosine monophosphate (cAMP)-dependent inhibition of a transcription factor known as myocyte enhancer ..
  6. Kinase/Phosphatase-mediated Mitochondrial Restructuring in Neuroprotection
    Stefan Strack; Fiscal Year: 2012
    ..integrates death and survival signals from the cytosol and from within mitochondria to restructure the organelle via reversible phosphorylation of the Drp1::Mff fission complex...
  7. Paco S Herson; Fiscal Year: 2016
    ..is of most direct importance, that (iii) the novel nitrosylation mechanisms contributes to ischemic damage by prolonging T286 phosphorylation, and that (iv) NR2B-binding enables efficient nitrosylation via localizing CaMKII near nNOS.
  8. Stefan Strack; Fiscal Year: 2016
    ..integrates death and survival signals from the cytosol and from within mitochondria to restructure the organelle via reversible phosphorylation of Drp1 at S656...
  9. GABA-B Receptor Modulation of Calcium Currents
    Michelle Mynlieff; Fiscal Year: 2010
    ..determine whether the enhancement of L-type calcium current is through activation of silent L-type calcium channels via a phosphorylation event...
  10. LRP AND ALZHEIMER'S DISEASE
    Bradley T Hyman; Fiscal Year: 2011
    ..Aim 1 tests the hypothesis that apoE/AB and a2M/AB complexes are cleared, and that this clearance is via LRP. We will determine the specific domains on LRP which mediate these processes...
  11. Regulation of Mitochondrial Fission/Fusion by PP2A and PKA in Neurons
    Stefan Strack; Fiscal Year: 2009
    ..are controlled by an opposing protein kinase and phosphatase that are localized to the outer mitochondrial membrane via specific targeting/regulatory subunits...
  12. Christopher W Cowan; Fiscal Year: 2015
    ..studies indicate that activation of cAMP/PKA signaling promotes the nuclear import of HDAC5 in striatal neurons via dephosphorylation of HDAC5 at a novel Cdk5 site...
  13. Habibeh Khoshbouei; Fiscal Year: 2014
    ..regulation of dopamine transporter function is through a physical interaction with the dopamine transporter via a shared binding domain with calcium calmodulin kinase II alpha (CaMKIIa) on the C-terminus domain of the dopamine ..
  14. Andy Hudmon; Fiscal Year: 2015
    ..Fourth, we have recently published that inhibiting CaMKII directly induces neuronal apoptosis via calcium dysregulation and hyperexcitability to aberrant glutamate signaling...
  15. Apolipoprotein E receptors and Alzheimers disease
    G William Rebeck; Fiscal Year: 2010
    ..Several groups have now defined that apoE receptors affect calcium influx via NMDA receptors and long term potentiation...
  16. CALCIUM CHANNELS, CALMODULIN AND NUCLEAR CREB SIGNALING
    Richard W Tsien; Fiscal Year: 2010
    ..We have found compelling evidence that signaling to CREB via the local pathway invokes a cooperative mechanism, similar to other forms of excitation-response coupling...
  17. Steven J Tavalin; Fiscal Year: 2015
    ..methods, and a novel imaging based approach to understand the: 1) Whether AKAP79 favors homomeric GluA1 receptors via GluA1 regulatory sites using a simplified heterologous system...
  18. Synaptic Mechanisms of Vestibular Efferent Responses
    JOSEPH CHRISTOPHER HOLT; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Vestibular organs, via their hair cells and afferent innervation, transmit information about the direction, speed, and magnitude of head and body movements, which are critical for maintaining our ..
  19. PAULUS ML JANSSEN; Fiscal Year: 2016
    ..experiments, we have formulated the hypothesis that myofilament-based frequency-dependent regulation is mediated via kinase-mediated phosphorylation, and that this process is deranged in hypertrophy and heart failure...
  20. JUAN ENRIQUE ROZENGURT; Fiscal Year: 2015
    ..the overarching hypothesis of this proposal is that CaSR signaling inhibits colon epithelial cell proliferation via down-regulation of b-catenin signaling...
  21. Linda A Barlow; Fiscal Year: 2016
    ..genetic tools to test the hypothesis that: Taste buds continually renew from a specialized set of progenitor cells via processes that are distinct from the surrounding epithelium, and regulated by Wnt/ss-catenin signaling. Aim 1...
  22. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  23. Bradley P Sutton; Fiscal Year: 2015
    ..Intellectual Merit: Prior studies of the topology of particular brain regions have been performed via invasive methods on post-mortem tissues and result in discussions of average brain changes across age, not specific ..
  24. Rona G Giffard; Fiscal Year: 2016
    ..BCL2 family proteins are central regulators of the life/death decision in cells (Adams et al, 2007), and via their regulation of mitochondrial membrane integrity and function control apoptosis signaling...
  25. Robert J Butera; Fiscal Year: 2016
    ..different constructs and parameters, the Optogenetic Population Clamp will pave the way for gene-therapeutic treatments of a variety of neurological disorders that employ closed-loop light stimulation via implanted fiber optics.
  26. Terence S Dermody; Fiscal Year: 2015
    ..Following peroral inoculation of newborn mice, reovirus infects intestinal mucosa, disseminates via hematogenous or neural routes, and targets the heart, liver, and central nervous system (CNS) to cause disease...
  27. AD classification algorithms using ADNI multi-modal image data
    Vikas Singh; Fiscal Year: 2010
    ..These algorithms will be implemented and disseminated via an easy to use software system to facilitate AD diagnosis (Specific Aim 3)...
  28. Kwabena Boahen; Fiscal Year: 2015
    ..the principled design of: (1) An entirely new class of encoders that can spatio-temporally pattern neural activity via optogenetic techniques...
  29. Inderjit Singh; Fiscal Year: 2014
    ..AICAR) or metformin attenuates EAE disease and provides neuro-protection via immunomodulation and protection of the blood brain barrier (BBB)...
  30. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..It has been clearly demonstrated that the long isoform of LepRs mediates cell signaling via the JAK family of tyrosine kinases and subsequent phosphorylation of STAT3...
  31. Rafael Yuste; Fiscal Year: 2016
    ..role in the circuit: they tile the CNS with near- complet coverage, are connected into an extensive syncytium via gap junctions, and processes from a single astrocyte can contact up to tens of thousands of synapses...
  32. Ann Arvin; Fiscal Year: 2016
    ..Our application will investigate how the gBcyt modulates cell- cell fusion mechanisms via intracellular signaling pathways to produce the characteristic syncytia in vitro and fusion of epidermal cells and ..
  33. Laurie J Ozelius; Fiscal Year: 2016
    ..The molecular counterparts of the behaviors will be assayed via measures of induction of phosphorylation of ERK and DARPP-32, following D1R, D2R, and A2AR receptor agonists and ..
  34. Seahorse XF96 Extracellular Flux Analyzer
    Enrique Saez; Fiscal Year: 2013
    ..for energy and various inhibitors of specific enzymes and metabolic pathways, which can be delivered automatically via four integrated injection ports, the Seahorse Extracellular Flux Analyzer provides an unprecedented, thorough and ..
  35. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
    ..interactions modulate the neurogenic inflammation by regulating the functional activity of TRPVi receptors via activating signal transduction cascades, such as protein kinase C (PKC)...
  36. ROBERT JOSEPH SHMOOKLER REIS; Fiscal Year: 2016
    ..levels of HSP/chaperones to refold transiently misfolded proteins (preventing their adherence to aggregates via exposed hydrophobic residues), protein repair of covalent molecular damage that would favor misfolding, and ..
  37. Jun Chen; Fiscal Year: 2014
    ..from different models suggests that the degeneration of dopaminergic neurons in PD is mediated at least in part via apoptosis-execution cascades...
  38. AARON DAVID MICKLE; Fiscal Year: 2014
    ..that PTHrP, by acting through its receptor PTH1 on sensory afferents, induce constitutive nociceptor sensitization via upregulation of activity/expression of the transient receptor potential vanilloid-1 (TRPV1) channel, which might ..
  39. Stimuli promoting the survival of spiral ganglion neurons
    Steven H Green; Fiscal Year: 2011
    ..This is reminiscent of the mechanism by which peptide neurotrophic factors suppress JNK signaling via their receptor protein-trosine kinases and PKB...
  40. Stefano Vicini; Fiscal Year: 2014
    ..This control is exerted via both phasic and tonic GABAa receptor activation...
  41. The Regulation of Plasma Membrane Estrogen Receptor-a Levels by Endocytosis
    Reymundo Dominguez; Fiscal Year: 2012
    ..a finding we corroborated in cortical neurons by showing internalization of membrane-impermeable estradiol via endosomes...
  42. HORMONE-NEUROTRANSMITTER INTERACTIONS IN THE BRAIN
    Elaine M Hull; Fiscal Year: 2011
    ..Glutamate elicits MPOA DA release, via NO, and is important for both sexual behavior and sexual learning...
  43. HING HUNG HENRY LAI; Fiscal Year: 2016
    ..Aim 2: To test the hypothesis that mGluR5 modulates bladder hyperalgesia via spinal ERK1/2 signaling and by modulating spinal neuronal excitability...
  44. Tae Wan Kim; Fiscal Year: 2015
    ..different species of A[unreadable], such as A[unreadable] oligomers and fibrils, may contribute to AD pathogenesis via distinct mechanisms at different stages of the disease...
  45. Modulation of GABAB receptor signaling
    Stephen J Moss; Fiscal Year: 2010
    ..preliminary studies have led us to formulate our central hypothesis: Prolonged exposure of neurons to glutamate via the activation of NMDA receptors inhibits AMPK-dependent phosphorylation of GABAB receptors...
  46. IL-6-mediated Jak2/Stat3 signaling and Brain Development
    Jun Tan; Fiscal Year: 2011
    ..potential effect on improving abnormal, autistic like social behaviors in IL-6/MIA offspring in adulthood via its attenuation of the JAK2/STAT3 signal pathway...
  47. Stephen J Moss; Fiscal Year: 2014
    ..This interaction is subject to dynamic modulation via the phosphorylation of serine residues within these intracellular domains, a process that determines both receptor ..
  48. Agonist-evoked changes in TRPV ion channel selectivity
    Michael J Caterina; Fiscal Year: 2011
    ..seek to identify amino acids that are selectively important for agonist-evoked pore dilation in TRPV1 and TRPV3 via systematic mutagenesis of residues within the domains adjacent to the selectivity filter...
  49. Dandan Sun; Fiscal Year: 2016
    ..For example, NKCC1 activity is up-regulated via protein phosphorylation following oxygen and glucose deprivation (OGD) and transient focal ischemia...
  50. PI(3,5)P2 synthesis in AMPA receptor trafficking and synaptic function
    AMBER JOYCE MCCARTNEY; Fiscal Year: 2012
    ..Under Aim 1, changes in AMPA receptor sorting will be assessed via biochemistry and immunofluorescence in cultured neurons from wild-type and mutant mice in which the essential ..
  51. Kevin J Staley; Fiscal Year: 2016
    ..is that seizure-induced changes in osmotic pressure favor movement of cations, Cl-i and water into neurons via cotransporters so that Cl-i increases and GABA signaling becomes excitatory...
  52. The Regulation of GABAA Receptor Cell Surface Stability
    Stephen Moss; Fiscal Year: 2009
    ..We hypothesize that the cell surface stability of GABAA receptors, is regulated via direct interactions with the AP2 complex, which plays an essential role in the recruitment of cargo into clathrin-..
  53. Durga Prasanna Mohapatra; Fiscal Year: 2015
    ..bone marrow, sensitize sensory neurons by enhancing TRPV1 channel activity in a phosphorylation-dependent manner, via activation of their respective receptors on sensory afferents...
  54. Pin1-dependent telomere regulation in aging and Alzheimer's disease
    Tae Ho Lee; Fiscal Year: 2010
    ..This study will have a significant impact upon our basic understanding of AD, and might eventually facilitate the development of novel treatments of AD via targeting of telomere maintenance.
  55. EFFECTS ON AB ON SYNAPTIC TRANMISSION AND PLASTICITY
    Paul Greengard; Fiscal Year: 2011
    ..work, we have found that the kinase, Cdk5 (previously implicated in AD), regulates dendritic spine morphology via phosphorylation of WAVE1 (a regulator of actin polymerization), and that Ap may regulate WAVE1 phosphorylation and ..
  56. Mechanisms of cytokine-mediated viral clearance from neurons
    LAUREN ALENE O apos DONNELL; Fiscal Year: 2010
    ..Our laboratory uses a transgenic mouse model of CNS-restricted MV infection via targeted neuronal expression of one of the measles virus receptors (CD46) to study interactions between MV-infected ..
  57. KENDRA BENCE; Fiscal Year: 2015
    ..We hypothesize that PTP1B and SHP2 have important metabolic roles specifically in these neurons via either leptin-dependent or - independent effects...
  58. Linda S Sorkin; Fiscal Year: 2014
    ..The proposal explores the possibility that TNF, via several identified steps, causes insertion of more and more active glutamate receptors into neuronal membranes to ..
  59. Regulatory mechanisms of proteasome function in neurons
    Gentry N Patrick; Fiscal Year: 2010
    ..Recent published findings support the idea that regulated proteolysis via the ubiquitin proteasome system (UPS) is required to promote, limit or restrict modulations in synaptic strength...
  60. Richard M Ransohoff; Fiscal Year: 2015
    ..soluble CX3CL1 released from neurons signals to CX3CR1 within microglia and plays a unique role in AD phenotypes via blocking phagocytic removal of A? by microglia and reducing phosphorylation and aggregation of MAPT within neurons ..
  61. SK2-associated protein kinase CK2: molecular basis and physiological roles
    John P Adelman; Fiscal Year: 2010
    Small conductance Ca2+-activated K+ channels (SK channels) are gated directly by Ca2+ ions, via constitutively associated calmodulin (CaM)...
  62. Regulation of Axonal Transport by the JNK (c-Jun N-terminal Kinase) Pathway
    Meng Meng Fu; Fiscal Year: 2013
    ..which has the ability to associate with JNK, both anterograde and retrograde motor proteins, and vesicles (via transmembrane proteins)...
  63. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  64. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..gt;50,000 sensors/cm2), automated microfluidic operation, and commercially validated manufacturability via CMOS-compatible processing...
  65. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..During these comprehensive annual visits, and via widely disseminated research flyers and outreach efforts (including over 60 activities in 2006), patients are ..
  66. Yasmin Wadia; Fiscal Year: 2014
    ..urine leak;d) damage to the kidney parenchyma evident by compromised renal function or long term renal function via creatinine clearance and MAG3 nuclear renal scan and e) mortality...
  67. SHAOCHUNG VICTOR HSIA; Fiscal Year: 2016
    ..In this project, we will further study the mechanisms by which T3/TR regulates HSV-1 replication/gene expression via the following Specific Aims. Specific Aim 1...
  68. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..to determine menstrual cycle-induced changes in cardiovascular risk factors and how inhibiting ovarian activity via hormonal oral contraceptives affects these factors...
  69. James D Bryers; Fiscal Year: 2016
    ..Our goal is to develop tissue regenerative biomaterials that will also provide a short-term defense and life long immune response to specific bacterial infections ..
  70. Tibor T Glant; Fiscal Year: 2016
    ..In Aim 1, we will narrow, and (if possible) separate genes of the Gpr107-Nsc1-Hmcn2 cluster via new recombinations by generating new IVSC mice (with even smaller Chr intervals or single genes), which will be ..
  71. Mitchell Kronenberg; Fiscal Year: 2014
    ..In Project 1, led by Dr. Liu, we will investigate how an E3 ubiquitin ligase, Cbl-b, stimulates Foxp3 induction, via a pathway that leads to increased activity of the transcription factor Foxo3a. Project 2, from Dr...
  72. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..Psychiatry at SLR on activation of the award, and will obtain further advice on advancement from formal mentors and via informal mentorship from other junior and senior investigators in the CU research network. Dr...
  73. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..eCB/CB1 receptor signaling is involved in the regulation of food consumption and metabolism via multiple mechanisms: it regulates the rewarding properties of food via effects on central mesolimbic pathways;it ..
  74. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..QT Prolongation in Beagle Dog via Implantable Telemetry: This study has been awarded to the lab to determine the sensitivity and specificity of the ..
  75. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..QT Prolongation in Beagle Dog via Implantable Telemetry: This study has been awarded to the lab to determine the sensitivity and specificity of the ..
  76. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..and enhances glucose disposal and glycogen storage by preventing desensitization of adrenergic receptor actions via suppression of insulin clearance and by maintaining of low NO levels...
  77. Noreen F Rossi; Fiscal Year: 2016
    ..whether exercise training will decrease arterial pressure and contralateral RSNA in 2K-1C (or sham-clipped) rats via inhibition of afferent nerve inputs from the clipped kidney;(2) We will evaluate whether exercise training ..
  78. DEBROSKI R HERBERT; Fiscal Year: 2016
    ..allergic reactions and worm infestation stimulate the differentiation of alternatively activated macrophages (AAMF) via exposure to IL-4 and/or IL-13 that promotes allergic disease and helminth destruction...
  79. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..This overload of excitotoxic chemicals incapacitates the victim via cholinergic toxidrome, resulting in seizures, paralysis, mucous secretions, eye irritation, cardiorespiratory ..
  80. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..6[unreadable]C by differential scanning calorimetry). Recombinant protein will be enriched via internal His-tag...
  81. Qinghua Sun; Fiscal Year: 2015
    ..5) pollution induces adipose dysfunction via reactive oxygen species (ROS)-dependent activation of endoplasmic reticulum (ER) stress and potentiation of insulin ..
  82. Melissa A Rosenkranz; Fiscal Year: 2014
    ..time, resources, and formal structure for Melissa to greatly expand her expertise in immunology and neuroanatomy via formal mentorship and advisory relationships, and to add a new neuroimaging modality (PET) to her repertoire of ..
  83. Patrice G Guyenet; Fiscal Year: 2015
    ..Third, the C1 neurons also regulate the circulation via the control that they exert over lower brainstem noradrenergic neurons (A5 and locus coeruleus)...
  84. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..For Aim 2, we will measure oxidative damage to DNA via 8OHdG in urine (oxidized, excreted DNA bases) and the comet assay (DNA strand breaks in lymphocytes) to test the ..
  85. Priyabrata Mukherjee; Fiscal Year: 2016
    ..Recent studies have shown that CBS can efficiently produce H2S via condensation of Cys and Hcy to form cystathionine and H2S...
  86. Susan Carnell; Fiscal Year: 2015
    ..Psychiatry at SLR on activation of the award, and will obtain further advice on advancement from formal mentors and via informal mentorship from other junior and senior investigators in the CU research network. Dr...
  87. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..We propose a more thorough abrogation of IRI-induced tissue damage via the deployment of a bifunctional PARP-1 inhibitor, R-503, formed from the covalent linkage of 2 moieties, each with ..
  88. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..Genetic loss of HDL via apoA-I deletion dramatically increases pulmonary inflammation and collagen deposition and increases airway ..
  89. Maria Diakonova; Fiscal Year: 2014
    ..These receptors are non tyrosine kinases, they transduce the signal via associated kinases that are recruited by the receptor and activated upon ligand binding...
  90. Jianming Qiu; Fiscal Year: 2016
    ..Furthermore, B19V replication in EPCs is markedly increased under hypoxic conditions and is mediated via the down-regulation of MEK/ERK signaling...
  91. THEA NOREEN GOLDEN; Fiscal Year: 2015
    ..During inflammation, NO production is increased via upregulation of inducible nitric oxide synthase (iNOS) expression in leukocytes and epithelial cells...
  92. Bethany B Moore; Fiscal Year: 2016
    ..Blockade of periostin interactions with the avb3 and avb5 integrins via the administration of the OC-20 monoclonal Ab could partially reverse periostin-mediated wound closure and ..
  93. UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2016
    ..to generate tight epithelial-stromal metabolic coupling with epithelial cancer cells with high OXPHOS metabolism via upregulation of monocarboxylate transporter 1 (MCT1), nuclear respiration factor 1 (NRF1) and mitoNEET and stromal ..
  94. ARUNKUMAR GOVINDAKARNAVAR; Fiscal Year: 2016
    ..cell count, and bacterial culture (where media/reagents are available) on cerebrospinal fluid (CSF) obtained via lumbar puncture from patients with AFI...
  95. Interplay Between Tissue Architecture and Nuclear Organization in the DNA Damage
    Pierre Alexandre Vidi; Fiscal Year: 2013
    ..Mechanotransduction or biochemical signaling via hemidesmosomal integrins may convey extracellular cues to the cell nucleus, leading to changes in nuclear ..