SHP-1

Summary

Gene Symbol: SHP-1
Description: protein tyrosine phosphatase, non-receptor type 6
Alias: HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, tyrosine-protein phosphatase non-receptor type 6, hematopoietic cell phosphatase, hematopoietic cell protein-tyrosine phosphatase, protein-tyrosine phosphatase 1C, protein-tyrosine phosphatase SHP-1
Species: human

Top Publications

  1. ncbi The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes
    N A Fanger
    Immunex Corporation, Seattle, Washington 98101, USA
    Eur J Immunol 28:3423-34. 1998
  2. pmc CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1
    J J Perez-Villar
    Immunology and Inflammation Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Mol Cell Biol 19:2903-12. 1999
  3. ncbi BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
    Norihiko Watanabe
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Immunol 4:670-9. 2003
  4. pmc Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype
    George P Christophi
    Department of Neurology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Lab Invest 89:742-59. 2009
  5. ncbi Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling
    D R Plas
    Howard Hughes Medical Institute, Center for Immunology, Washington University Medical School, St Louis, Missouri 63110, USA
    Science 272:1173-6. 1996
  6. ncbi SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors
    B A Binstadt
    Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 273:27518-23. 1998
  7. ncbi Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase
    G G Chiang
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 276:23173-8. 2001
  8. pmc Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif
    Issa Abu-Dayyeh
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    PLoS Negl Trop Dis 2:e305. 2008
  9. ncbi Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2
    T Ulyanova
    Howard Hughes Medical Institute, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 276:14451-8. 2001
  10. doi Calpain-dependent cleavage of SHP-1 and SHP-2 is involved in the dephosphorylation of Jurkat T cells induced by Entamoeba histolytica
    K A Kim
    Department of Environmental Medical Biology, Institute of Tropical Medicine, and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Parasite Immunol 32:176-83. 2010

Research Grants

  1. Clifford A Lowell; Fiscal Year: 2016
  2. System for Tracking and Managing Pain (STAMP)
    Wendy A Rogers; Fiscal Year: 2012
  3. Redox control of CD8 T cell proliferation, differentiation and death
    JASON MITCHELL GRAYSON; Fiscal Year: 2012
  4. Renate B Pilz; Fiscal Year: 2014
  5. HoxA10 Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
  6. Dana E Niles; Fiscal Year: 2015
  7. Paul T Massa; Fiscal Year: 2015
  8. Examining the Costs of a Medical Home Transformation for Seniors
    Arturo Vargas Bustamante; Fiscal Year: 2013
  9. Role of SHP-1 in T cell activation and development
    Ulrike Lorenz; Fiscal Year: 2009
  10. P120 AND CELL CELL ADHESION
    Albert B Reynolds; Fiscal Year: 2010

Detail Information

Publications276 found, 100 shown here

  1. ncbi The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes
    N A Fanger
    Immunex Corporation, Seattle, Washington 98101, USA
    Eur J Immunol 28:3423-34. 1998
    ..These findings suggest that LIR-1 and LIR-2 function as unique MHC class I receptors involved in the inhibition or down-modulation of monocyte activation signals, particularly those mediated through the receptors for IgG, IgE and IgA...
  2. pmc CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1
    J J Perez-Villar
    Immunology and Inflammation Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Mol Cell Biol 19:2903-12. 1999
    ..These results suggest a critical role of the CD5 ITIM-like motif, which by binding to SHP-1 mediates the down-regulatory activity of this receptor...
  3. ncbi BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
    Norihiko Watanabe
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Immunol 4:670-9. 2003
    ..B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1)...
  4. pmc Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype
    George P Christophi
    Department of Neurology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Lab Invest 89:742-59. 2009
    ....
  5. ncbi Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling
    D R Plas
    Howard Hughes Medical Institute, Center for Immunology, Washington University Medical School, St Louis, Missouri 63110, USA
    Science 272:1173-6. 1996
    ..Expression of a dominant negative mutant of SHP-1 in T cells increased the sensitivity of the antigen receptor. Thus, SHP-1 functions as a negative regulator of the T cell antigen receptor and in setting the threshold of activation...
  6. ncbi SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors
    B A Binstadt
    Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 273:27518-23. 1998
    ....
  7. ncbi Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase
    G G Chiang
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 276:23173-8. 2001
    ..The failure of SHP-1 to inactivate Lck may contribute to some of the lymphoid abnormalities observed in motheaten mice...
  8. pmc Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif
    Issa Abu-Dayyeh
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    PLoS Negl Trop Dis 2:e305. 2008
    ..We thus provide the first demonstration that a pathogen can exploit a host protein tyrosine phosphatase, namely SHP-1, to directly inactivate IRAK-1 through a generally conserved KTIM motif...
  9. ncbi Molecular cloning of MIS, a myeloid inhibitory siglec, that binds protein-tyrosine phosphatases SHP-1 and SHP-2
    T Ulyanova
    Howard Hughes Medical Institute, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 276:14451-8. 2001
    ..Moreover, MIS exerted an inhibitory effect on FcgammaRI receptor-induced calcium mobilization. These data suggest that MIS can play an inhibitory role through its ITIM sequences...
  10. doi Calpain-dependent cleavage of SHP-1 and SHP-2 is involved in the dephosphorylation of Jurkat T cells induced by Entamoeba histolytica
    K A Kim
    Department of Environmental Medical Biology, Institute of Tropical Medicine, and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Parasite Immunol 32:176-83. 2010
    ..These results suggest that calpain-dependent cleavage of SHP-1 and SHP-2 may contribute to protein tyrosine dephosphorylation in Jurkat T cell death induced by E. histolytica...
  11. ncbi Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1
    Kenneth W Harder
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Blood 104:3901-10. 2004
    ..We also show that mice lacking SHIP-1 have defects in the erythroid and myeloid compartments similar to those in mice lacking Lyn or SHP-1, suggesting an intimate relationship between Lyn, SHP-1, and SHIP-1 in regulating hematopoiesis...
  12. ncbi Analysis of SHP-1-mediated down-regulation of the TRK-T3 oncoprotein identifies Trk-fused gene (TFG) as a novel SHP-1-interacting protein
    Emanuela Roccato
    Department of Experimental Oncology Operative Unit Molecular Mechanisms of Cancer Growth and Progression, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milan, Italy
    J Biol Chem 280:3382-9. 2005
    ..Our data contribute to the definition of cellular mechanisms involved in thyroid tumorigenesis. Moreover, it reveals TFG as a novel protein able to modulate SHP-1 activity...
  13. pmc Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation
    You Sook Cho
    Division of Allergy and Clinical Immunology, Johns Hopkins Asthma Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Am J Respir Cell Mol Biol 39:412-9. 2008
    ..Thus, increased intracellular oxidative stress and lack of SHP-1 in the presence of T helper cell type 2-prone cellular activation may lead to the development of allergic airway inflammation...
  14. pmc mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2
    Z Yu
    Pharmaceutical Sector, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada H4P 2R2
    Biochem J 353:483-92. 2001
    ..The gene encoding mSiglec-E is localized in the same chromosome as that encoding mouse CD33. Phylogenetic analysis reveals that neither mouse mSiglec-E nor CD33 shows a clear relationship with any human siglecs so far identified...
  15. pmc CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation
    C L Law
    Department of Microbiology, University of Washington, Seattle 98195, USA
    J Exp Med 183:547-60. 1996
    ..These results suggest that tyrosyl-phosphorylated CD22 may be a substrate for PTP-1C regulates tyrosyl phosphorylation of CD22...
  16. ncbi PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta
    D D Mousseau
    Mammalian Cell Genetics, National Research Council Biotechnology Research Institute, Montreal, Quebec H4P 2R2
    J Biol Chem 275:4467-74. 2000
    ..The PILRalpha and PILRbeta genes are localized to chromosome 7 which is in contrast with the mapping of known members of the inhibitory receptor superfamily...
  17. pmc Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1
    H Keilhack
    Research Unit, Molecular Cell Biology, D 07747 Jena, Germany
    J Cell Biol 152:325-34. 2001
    ..Overexpression of SHP-1 results in Ros dephosphorylation and effectively downregulates Ros-dependent proliferation and transformation. We propose that SHP-1 is an important downstream regulator of Ros signaling...
  18. ncbi Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration
    Wen Mei Yu
    Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Blood 99:2351-9. 2002
    ..these mutant Gab2 molecules also significantly ameliorated their enhanced migration capacity associated with the SHP1 gene mutation...
  19. doi SHP-1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome-positive cells derived from patients with chronic myeloid leukemia
    Nicola Esposito
    CEINGE Biotecnologie Avanzate, Naples, Italy
    Blood 118:3634-44. 2011
    ..0001). In conclusion, we suggest that SHP-1 could be a new biologic indicator at baseline of IMA sensitivity in patients with chronic myelogenous leukemia...
  20. ncbi sst2 somatostatin receptor mediates negative regulation of insulin receptor signaling through the tyrosine phosphatase SHP-1
    C Bousquet
    INSERM U151, Institut Louis Bugnard, IFR 31, CHU Rangueil, 31403 Toulouse Cedex 04, France
    J Biol Chem 273:7099-106. 1998
    ..Furthermore, somatostatin inhibits the insulin-induced mitogenic signal by accelerating and amplifying the effect of SHP-1 on the termination of the insulin signaling pathway...
  21. ncbi Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells
    J G Sathish
    Department of Medicine, University of Wales College of Medicine, Cardiff, Wales, United Kingdom
    J Immunol 166:1763-70. 2001
    ..We propose that this mechanism may exert a constitutive negative regulatory role upon T cell signaling...
  22. ncbi Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF
    Mitsue Kurita-Taniguchi
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka, Japan
    Mol Immunol 38:689-700. 2002
    ..The molecular complex involving CD46 may confer high MV permissiveness leading to immune modulation in Mphi...
  23. ncbi Negative regulation of beta-catenin signaling by tyrosine phosphatase SHP-1 in intestinal epithelial cells
    Cathia Duchesne
    Département d Anatomie et Biologie Cellulaire, Faculte de Medecine, Universite de Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 278:14274-83. 2003
    ..Taken together, our results indicate that SHP-1 may be involved in the regulation of beta-catenin transcriptional function and in the negative control of intestinal epithelial cell proliferation...
  24. pmc STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:6948-53. 2005
    ..Reversal of such gene silencing represents an attractive aim for novel anticancer therapies...
  25. ncbi LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes
    L Meyaard
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304 1104, USA
    Immunity 7:283-90. 1997
    ....
  26. pmc Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1
    Ajaikumar B Kunnumakkara
    Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Res 7:118-28. 2009
    ..Overall, our results suggest that AKBA is a novel inhibitor of STAT3 activation and has potential in the treatment of cancer...
  27. ncbi Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase
    P A Ram
    Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 272:17694-702. 1997
    ..No such association of SHP-1 with GH-activated STAT3 was detected, a finding that could help explain the marked desensitization of STAT3, but not STAT5b, to subsequent GH pulses following an initial GH activation event...
  28. ncbi The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling
    F Lopez
    INSERM Unité 151, Institut Louis Bugnard, CHU Rangueil, F 31403 Toulouse Cedex, France
    J Biol Chem 272:24448-54. 1997
    ..Our data identify SHP-1 as the tyrosine phosphatase associated with sst2 and demonstrate that this enzyme may be an initial key transducer of the antimitogenic signaling mediated by sst2...
  29. ncbi High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages
    A Veillette
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Biol Chem 273:22719-28. 1998
    ..Taken together, these findings indicate that SHPS-1 is likely to play a significant role in macrophages, at least partially as a consequence of its capacity to recruit SHP-1...
  30. ncbi The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1
    Y Wu
    Program in Molecular Biology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Curr Biol 8:1009-17. 1998
    ..Moreover, direct substrates of SHP-1 have not been identified in any B-cell signaling pathway...
  31. ncbi Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1
    J Yang
    Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, USA
    J Biol Chem 273:28199-207. 1998
    ..Our mutagenesis and kinetic measurements have supported this hypothesis...
  32. ncbi Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates
    C T Hua
    Division of Human Immunology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia, 5000 Australia
    J Biol Chem 273:28332-40. 1998
    ....
  33. ncbi Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function
    J R Carlyle
    Departments ofImmunology and Anatomy and Cell Biology, University of Toronto, Toronto, Ontario, Canada
    J Immunol 162:5917-23. 1999
    ..The existence of these two NK1.1 Ags with opposite functions suggests a potential role for NKR-P1 molecules, such as those of the Ly-49 gene family, in regulating NK cell function...
  34. ncbi Regulation of acidification and apoptosis by SHP-1 and Bcl-2
    M Thangaraju
    Fraser Laboratories, Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Quebec, H3A 1A1
    J Biol Chem 274:29549-57. 1999
    ....
  35. ncbi SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates
    T Adachi
    Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    J Biol Chem 276:26648-55. 2001
    ....
  36. ncbi Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia
    Takashi Angata
    Glycobiology Research and Training Center, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0687, USA
    J Biol Chem 277:24466-74. 2002
    ....
  37. ncbi Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1
    Friederike Kitzig
    Molecular Immunopathology Unit, DCEXS, Universitat Pompeu Fabra, Barcelona, Spain
    Biochem Biophys Res Commun 296:355-62. 2002
    ..Finally, we demonstrated that Siglec-10 was not able to bind SAP/SH2d1A, indicating that the so-called CD150-like motif in Siglec-10 might be a docking site for other signal transduction mediators...
  38. pmc Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity
    Christopher C Stebbins
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Mol Cell Biol 23:6291-9. 2003
    ..Such a mechanism explains how inhibitory receptors can block activating signals induced by different receptors...
  39. ncbi CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation
    Dong Hui Chung
    Veterans Administration Medical Center and University of California, San Francisco, CA 94121, USA
    J Immunol 171:6541-8. 2003
    ..Thus, we define a new family of myeloid receptors, and demonstrate that the first member of this family, CLM-1, is an inhibitory receptor, able to block osteoclastogenesis...
  40. ncbi The protein-tyrosine phosphatase SHP-1 regulates the phosphorylation of alpha-actinin
    Siang Yo Lin
    Department of Surgery, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey and the Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA
    J Biol Chem 279:25755-64. 2004
    ....
  41. ncbi SRC homology-2-containing protein tyrosine phosphatase-1 restrains cell proliferation in human medullary thyroid carcinoma
    Maria Chiara Zatelli
    Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy
    Endocrinology 146:2692-8. 2005
    ..Our data demonstrate that SRIF inhibitory effects on TT cell proliferation are mediated, at least in part, by SHP-1, which acts through a MAPK-dependent mechanism...
  42. ncbi Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions
    Carl F Fortin
    Laboratory for Immunology, Research Center on Aging, Clinical Research Center, and Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    J Leukoc Biol 79:1061-72. 2006
    ..Our results suggest an alteration of the SHP-1 modulation by GM-CSF in lipid rafts of PMN with aging. These alterations could contribute to the decreased GM-CSF effects on PMN...
  43. ncbi Identification of a novel lipid raft-targeting motif in Src homology 2-containing phosphatase 1
    Mohan Sankarshanan
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Immunol 179:483-90. 2007
    ..Taken together, these data define a novel 6-mer motif within SHP-1 that is necessary and sufficient for lipid raft localization and for the function of SHP-1 as a negative regulator of TCR signaling...
  44. pmc Isolation of a src homology 2-containing tyrosine phosphatase
    J Plutzky
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02118
    Proc Natl Acad Sci U S A 89:1123-7. 1992
    ..The structure of SH-PTP1 establishes an additional branch of the tyrosine phosphatase family and suggests mechanisms through which tyrosine phosphatases might participate in signal transduction pathways...
  45. ncbi Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains
    T Uchida
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    J Biol Chem 269:12220-8. 1994
    ....
  46. ncbi A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP
    G M Doody
    Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, School of Clinical Medicine, UK
    Science 269:242-4. 1995
    ..In secondary lymphoid organs, CD22 may be sequestered away from mIg through interactions with counterreceptors on T cells. Thus, CD22 is a molecular switch for SHP that may bias mIg signaling to anatomic sites rich in T cells...
  47. ncbi Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts
    D Banville
    Pharmaceutical Biotechnology Sector, Biotechnology Research Institute, Montreal, Quebec, Canada
    Genomics 27:165-73. 1995
    ..Characterization of the 5' ends of the PTPN6 mRNAs by RT-PCR and analysis of the flanking genomic sequences identified putative initiation sites within the two promoters...
  48. ncbi Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
    U Klingmuller
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 80:729-38. 1995
    ..We show that the hematopoietic protein tyrosine phosphatase SH-PTP1 (also called HCP and PTP1C) associates via its SH2 domains with the tyrosine-phosphorylated EPO-R...
  49. pmc Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells
    U Lorenz
    Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts 02215
    Mol Cell Biol 14:1824-34. 1994
    ..In comparison, little is known about the role of nontransmembrane PTPs in early T-cell signaling. SH-PTP1 (PTP1C, HCP, SHP) is a nontransmembrane PTP expressed primarily in hematopoietic cells, including T cells...
  50. pmc Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1
    M David
    Division of Cytokine Biology, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892, USA
    Mol Cell Biol 15:7050-8. 1995
    ..We have found that SH2 domain-containing PTP1 (SHPTP1; also called PTP1C, HCP, or SHP) reversibly associates with the IFN-alpha receptor complex upon IFN addition...
  51. pmc Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor
    D N Burshtyn
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Immunity 4:77-85. 1996
    ..We report association of the tyrosine phosphatase HCP with the p58 receptor in NK cells. HCP association was dependent on tyrosine phosphorylation of p58...
  52. ncbi Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase
    A K Somani
    Department of Medicine, University of Toronto and The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 272:21113-9. 1997
    ..These observations, together with the finding of reduced Src activity in HEY cells expressing a dominant negative form of SHP-1, provide compelling evidence that SHP-1 functions include the positive regulation of Src activation...
  53. ncbi The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells
    J Kroll
    Department of Internal Medicine II Cardiology, Ulm University Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Federal Republic of Germany
    J Biol Chem 272:32521-7. 1997
    ..Taken together, our results substantially broaden the spectrum of KDR-associating molecules, indicating that endothelial function and angiogenesis are regulated by a diverse network of signal transduction cascades...
  54. pmc SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain
    M Kozlowski
    Health Canada Life Sciences and the University of Ottawa, Canada
    Mol Cell Biol 18:2089-99. 1998
    ....
  55. pmc Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages
    J F Timms
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 18:3838-50. 1998
    ..Our data suggest that BIT and PIR-B recruit multiple signaling molecules to receptor complexes, where they are regulated by SHP-1 and/or SHP-2...
  56. ncbi Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling
    H Keilhack
    Research Unit Molecular Cell Biology, Medical Faculty, Friedrich Schiller University, D 07747 Jena, Germany
    J Biol Chem 273:24839-46. 1998
    ..Therefore, receptor dephosphorylation may be the result of the combined activity of receptor-bound SHP-1 and SHP-1 bound to an auxiliary docking protein...
  57. ncbi Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells
    C Cantoni
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Eur J Immunol 29:3148-59. 1999
    ..Since IRp60 is also expressed by other cell types, including T cell subsets, monocytes and granulocytes, it may play a more general role in the negative regulation of different leukocyte populations...
  58. ncbi Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase
    B D Cuevas
    Division of Medicine, Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 276:27455-61. 2001
    ..a process that we have shown to be reversed by the activity of the p85-associated SH2 domain-containing phosphatase SHP1. We demonstrate that phosphorylation of the downstream PI3K target Akt is increased in cells lacking SHP1, ..
  59. ncbi SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC
    Anita M Kant
    Herman B Wells Center for Pediatrics Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 100:1852-9. 2002
    ....
  60. ncbi Modulation of the ERG K+ current by the tyrosine phosphatase, SHP-1
    Francisco S Cayabyab
    Cellular and Molecular Biology Division, Toronto Western Research Institute, Ontario M5T 2S8, Canada
    J Biol Chem 277:48130-8. 2002
    ..Our results show that ERG-1 is a SHP-1 substrate constituting the first report that an ion current is regulated by SHP-1...
  61. ncbi The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation
    Zhongsen Zhang
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:4668-74. 2003
    ....
  62. ncbi The protein-tyrosine phosphatase SHP-1 associates with the phosphorylated immunoreceptor tyrosine-based activation motif of Fc gamma RIIa to modulate signaling events in myeloid cells
    Latha P Ganesan
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, The Dorothy M Davis Heart and Lung Institute, and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 278:35710-7. 2003
    ..Finally, overexpression of wild-type SHP-1 but not catalytically deficient SHP-1 led to a down-regulation of NF kappa B-dependent gene transcription in THP-1 cells activated by clustering Fc gamma RIIa...
  63. ncbi SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway
    Chor Sang Chim
    University Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong
    Blood 103:4630-5. 2004
    SOCS1 and SHP1 negatively regulate the Janus kinase/signal transducer and activator of transcription (Jak/STAT) signaling pathway...
  64. ncbi Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus
    Matthew L Jones
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 279:40475-83. 2004
    ....
  65. ncbi Visualization of SHP-1-target interaction
    Christoph Biskup
    Institute of Physiology II, Medical Faculty, Friedrich Schiller University, Drackendorfer Str 1, 07747 Jena, Germany
    J Cell Sci 117:5165-78. 2004
    ....
  66. pmc Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells
    Dong Wan Seo
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 1500, USA
    J Biol Chem 281:3711-21. 2006
    ....
  67. pmc SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients
    George P Christophi
    Department of Neurology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Lab Invest 88:243-55. 2008
    ..Thus, PBMCs of MS patients display a stable deficiency of SHP-1 expression, heightened STAT6 phosphorylation, and an enhanced state of activation relevant to the mechanisms of inflammatory demyelination...
  68. doi Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery
    F J Rodríguez-Ubreva
    Departamento de Bioquimica y Biologia Molecular, Universidad de Alcala, Alcala de Henares, E 28871 Madrid, Spain
    Oncogene 29:345-55. 2010
    ..This study shows that SHP-1 depletion promotes cell-cycle arrest by modulating the activity of cell-cycle regulators and suggests that SHP-1 may be required for the proper functioning of events governing cell-cycle progression...
  69. ncbi SHP-1 in cell-cycle regulation
    Pilar López-Ruiz
    Department of Biochemistry and Molecular Biology, University of Alcala, Alcala de Henares, Madrid, Spain
    Anticancer Agents Med Chem 11:89-98. 2011
    ..Since several inhibitors targeting SHP-1 have demonstrated their value in cancer treatment, this phosphatase has been proposed as a therapeutic target for this pathology...
  70. doi Inhibitory ITAM signaling traps activating receptors with the phosphatase SHP-1 to form polarized "inhibisome" clusters
    Séverine Pfirsch-Maisonnas
    INSERM U699, F 75018 Paris, France
    Sci Signal 4:ra24. 2011
    ....
  71. doi Breast cancer cells proliferation is regulated by tyrosine phosphatase SHP1 through c-jun N-terminal kinase and cooperative induction of RFX-1 and AP-4 transcription factors
    Shahreen Amin
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    Mol Cancer Res 9:1112-25. 2011
    ..Tyrosine phosphatase SHP1 is known to negatively regulate signal transduction pathways activated by cell surface receptors including IGF-1...
  72. pmc Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway
    Yash Mittal
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:32404-15. 2011
    ..We conclude that SHP-1 antagonizes the action of receptor and non-receptor-tyrosine kinases on GIV and down-regulates the phospho-GIV-PI3K-Akt axis of signaling...
  73. pmc A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling
    Peisong Ma
    Department of Medicine and Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Blood 119:1935-45. 2012
    ..We also show that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical ..
  74. pmc The endothelial tyrosine phosphatase SHP-1 plays an important role for vascular haemostasis in TNFα -induced inflammation in vivo
    Elisabeth Koch
    Medizinische Klinik und Poliklinik IV, Innenstadt, Ludwig Maximilians Universitat Munchen, Ziemssenstr 1, 80336 Munich, Germany
    Mediators Inflamm 2013:279781. 2013
    ..In this study we investigated the influence of SHP-1 on platelet-endothelium interaction and arterial thrombosis in TNFα -induced endothelial inflammation in vivo...
  75. pmc Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13
    T L Yi
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Mol Cell Biol 12:836-46. 1992
    ..One novel protein tyrosine phosphatase was expressed predominantly in hematopoietic cells. Hematopoietic cell phosphatase encodes a 68-kDa protein that contains a single phosphatase conserved domain...
  76. ncbi Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains
    D Pei
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Biochemistry 33:15483-93. 1994
    The steady-state kinetic properties of SH-PTP1 (PTP1C, SHP, HCP), a Src homology 2 (SH2) domain-containing protein tyrosine phosphatase (PTPase), were assessed and compared with those of three truncation mutants, using p-nitrophenyl ..
  77. ncbi Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase
    A Yetter
    Division of Hematology Oncology, Loyola University of Chicago, Maywood, Illinois 60153, USA
    J Biol Chem 270:18179-82. 1995
    ..We report that Tyk-2 forms stable complexes with the SH2-containing hematopoietic cell phosphatase (HCP) in several hematopoietic cell lines in vivo, and that the IFN alpha-induced tyrosine-..
  78. ncbi Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1
    D D'Ambrosio
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA
    Science 268:293-7. 1995
    ..Inhibitory signaling mediated by Fc gamma RIIB1 is deficient in motheaten mice which do not express functional PTP1C. Thus, PTP1C is an effector of BCR-Fc gamma RIIB1 negative signal cooperativity...
  79. ncbi Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases
    L Olcese
    Center for Immunology, INSERM CNRS of Marseille Luminy, France
    J Immunol 156:4531-4. 1996
    ....
  80. pmc Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C
    A M Fry
    Department of Microbiology and Immunology, Howard Hughes Medical Institute University of California, San Francisco 94143, USA
    J Exp Med 184:295-300. 1996
    ..phosphorylation of the NKB1 KIR consensus motif, YxxL(x)26 YxxL, induces an association with the protein tyrosine phosphatase 1C (PTP1C)...
  81. pmc Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C
    K S Campbell
    Basel Institute for Immunology, Switzerland
    J Exp Med 184:93-100. 1996
    ..These results implicate PTP-1C as a cytosolic component of the negative signaling pathway through NK cell inhibitory receptors...
  82. pmc Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1
    H Jiao
    Department of Cancer Biology, The Cleveland Clinic Foundation Research Institute, Ohio 44195, USA
    Mol Cell Biol 16:6985-92. 1996
    ..They also suggest that such interactions may provide one of the mechanisms that control SHP-1 substrate specificity...
  83. ncbi A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1
    D N Burshtyn
    Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 272:13066-72. 1997
    ..The contribution of a hydrophobic amino acid two residues upstream of the tyrosine in the SHP-1-binding motif may be an important feature that distinguishes inhibitory receptors from those that provide activation signals...
  84. ncbi SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity
    B Cuevas
    Division of Medicine, and the Cell Growth Regulation Laboratory, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 274:27583-9. 1999
    ....
  85. ncbi Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome
    Erica M Hanson
    Department of Immunology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 278:3903-11. 2003
    ..These results suggest that the loss of tyrosine phosphorylation of Stat6 is regulated by the action of SHP-1 and the proteasome but is not dependent on new protein synthesis...
  86. ncbi Receptor activator of NF-kappa B ligand stimulates recruitment of SHP-1 to the complex containing TNFR-associated factor 6 that regulates osteoclastogenesis
    Zhiyuan Zhang
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 171:3620-6. 2003
    ..Therefore, SHP-1 plays a role in signals downstream of RANKL by recruitment to the complex containing TRAF6 and these observations may help to understand the mechanism of osteoporosis in Me(v)/Me(v) mice...
  87. ncbi Dysmyelination and reduced myelin basic protein gene expression by oligodendrocytes of SHP-1-deficient mice
    Paul T Massa
    Department of Neurology, Neuroscience Program, SUNY Upstate Medical University, Syracuse, New York 13066, USA
    J Neurosci Res 77:15-25. 2004
    ..We propose that SHP-1 is a critical regulator of developmental signals leading to terminal differentiation and myelin sheath formation by oligodendrocytes...
  88. pmc Mechanisms of SHP-1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV-1-transformed T cells
    Koichi Nakase
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
    J Leukoc Biol 85:165-74. 2009
    ....
  89. ncbi A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases
    S H Shen
    Section of Molecular Genetics, National Research Council of Canada, Montreal, Quebec
    Nature 352:736-9. 1991
    ..PTPase activity may thus directly link growth factor receptors and other signalling proteins through protein-tyrosine phosphorylation...
  90. ncbi SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates
    H Bone
    School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom
    J Biol Chem 272:14470-6. 1997
    The cytoplasmic tyrosine phosphatases, SHP1 and SHP2, are implicated in the control of cellular proliferation and survival...
  91. ncbi Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation
    B A Binstadt
    Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Immunity 5:629-38. 1996
    ..These results suggest sequential roles for Lck and SHP-1 in the inhibition of PTK following MHC recognition by NK cells...
  92. ncbi Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B
    J Tao
    Department of Molecular Pharmacology, University Medical Center, State University of New York, Stony Brook, New York 11794-8651, USA
    J Biol Chem 276:39705-12. 2001
    ..These data provide the first molecular basis for the interplay between Galpha(i2) and insulin signaling, i.e. activation of Galpha(i2) can suppress both the expression and activity of PTP1B in insulin-sensitive tissues...
  93. doi Diagnostic strategies for autosomal dominant acute porphyrias: retrospective analysis of 467 unrelated patients referred for mutational analysis of the HMBS, CPOX, or PPOX gene
    Sharon D Whatley
    Department of Medical Biochemistry and Immunology, University Hospital of Wales and School of Medicine, Cardiff University, Cardiff, UK
    Clin Chem 55:1406-14. 2009
    Clinically indistinguishable attacks of acute porphyria occur in acute intermittent porphyria (AIP), hereditary coproporphyria (HCP), and variegate porphyria (VP). There are few evidence-based diagnostic strategies for these disorders.
  94. ncbi Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2007
    Anthony E Fiore
    Influenza Division, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 56:1-54. 2007
    ..including young children and adults with risk factors for influenza complications, health-care personnel (HCP), and pregnant women...
  95. doi SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein
    Mélanie Simoneau
    Département d Anatomie et Biologie Cellulaire, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke Quebec, Canada
    Cell Signal 23:269-79. 2011
    ....
  96. doi Formation of smooth muscle alpha actin filaments in CD34+ bone marrow cells on arterial elastic laminae: potential role of SH2 domain-containing protein tyrosine phosphatase-1
    Shu Q Liu
    Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3107, United States
    Matrix Biol 27:282-94. 2008
    ..These observations suggest that elastic laminae stimulate the formation of SM alpha actin filaments in CD34+ bone marrow cells and SHP-1 mediates the stimulatory effect of elastic laminae...
  97. ncbi [Control of staphylococcal skin infections in a nursery]
    F Y Huang
    Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan, R O C
    Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 32:165-70. 1991
    ..developed in January 1985, and declined dramatically to 3 cases in March of the same year when 3% hexachlorophene (HCP) bathing was used (period 1-January 1985 to March 1985)...
  98. ncbi The occurrence of obstructive vs absorptive hydrocephalus in newborns and infants: relevance to treatment choices
    Liana Beni-Adani
    Department of Pediatric Neurosurgery, Dana Children s Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman St, Tel Aviv, 64239, Israel
    Childs Nerv Syst 22:1543-63. 2006
    ..The objective of this paper is to present the spectrum of obstructive-communicating hydrocephalus, which is more complex in the pediatric group, and to propose the relevance of this particular classification to treatment options...
  99. pmc Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus
    Paul T Massa
    Department of Neurology, Upstate Medical University, State University of New York, Syracuse 13210, USA
    J Virol 76:8335-46. 2002
    ..These findings indicate that SHP-1 is a critical factor in controlling virus replication in the CNS glia and virus-induced demyelination...
  100. ncbi Analysis for residual host cell proteins and DNA in process streams of a recombinant protein product expressed in Escherichia coli cells
    Anurag Singh Rathore
    Amgen Inc, Mail Stop 30W 2 A, One Amgen Center Drive, Thousand Oakes, CA 91320, USA
    J Pharm Biomed Anal 32:1199-211. 2003
    ..finalized, there is a tremendous volume of testing required to confirm the absence of residual host cell proteins (HCP) and DNA. Analytical tests for these components are very challenging since (1)...
  101. doi New insights into the relationship of neurogenesis and affect: tickling induces hippocampal cell proliferation in rats emitting appetitive 50-kHz ultrasonic vocalizations
    M Wohr
    Experimental and Physiological Psychology, Philipps University, Gutenbergstrasse 18, Marburg, Germany
    Neuroscience 163:1024-30. 2009
    Adult hippocampal cell proliferation (HCP) has been associated with psychopathology, especially depression...

Research Grants69

  1. Clifford A Lowell; Fiscal Year: 2016
    ..This will lead to better design of therapeutcs to target immune diseases, as well as leukemia and lymphoma. ..
  2. System for Tracking and Managing Pain (STAMP)
    Wendy A Rogers; Fiscal Year: 2012
    ..2) Shared Medical Decision-making on treatment goals and options [2, 35, 39] through patient-healthcare provider (HCP) collaboration...
  3. Redox control of CD8 T cell proliferation, differentiation and death
    JASON MITCHELL GRAYSON; Fiscal Year: 2012
    ....
  4. Renate B Pilz; Fiscal Year: 2014
    ..These studies will provide the foundation for novel and improved treatment strategies in osteoporosis. ..
  5. HoxA10 Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..In undifferentiated myeloid cells, we found that HoxA10 is maintained in a non-tyrosine phosphorylated state by SHP1 and SHP2 protein tyrosine phosphatases...
  6. Dana E Niles; Fiscal Year: 2015
    ..However, healthcare provider (HCP) anxiety, operator position, HCP training, crowded bed space and infant size are significant barriers to timely and ..
  7. Paul T Massa; Fiscal Year: 2015
    ..These studies will be critical to defining the autonomous activity of SHP-1 in controlling ROS production in oligodendrocytes and resulting demyelinating processes in vivo. ..
  8. Examining the Costs of a Medical Home Transformation for Seniors
    Arturo Vargas Bustamante; Fiscal Year: 2013
    ..by comparing costs of a wellness care redesign for older adult patients of HealthCare Partners Medical Group (HCP), an integrated medical group with 31 practice sites, and 213 practices sites of HCP's network of Independent ..
  9. Role of SHP-1 in T cell activation and development
    Ulrike Lorenz; Fiscal Year: 2009
    ..In addition, we expect to gain a better understanding of factors that influence the development and function of CD4+CD25+ Treg cells with a focus on the role of SHP-1 during these processes. ..
  10. P120 AND CELL CELL ADHESION
    Albert B Reynolds; Fiscal Year: 2010
    ..g, PER, Fyn, Yes) and -phosphatases (eg, PTPa, DEP1, SHP1)...
  11. Substrate Profiling of Protein Tyrosine Phosphatases
    Dehua Pei; Fiscal Year: 2013
    ..abstract_text> ..
  12. Evaluating the Impact of Mandatory Influenza Vaccination for Hospital Workers in
    KATHERINE MARIE HARRIS; Fiscal Year: 2011
    ..Our preliminary data suggests that nationally, uptake of seasonal vaccine is roughly twice as high among HCP subject to employer mandates compared to those who are not...
  13. Natarajan Muthusamy; Fiscal Year: 2016
    ..in this proposal demonstrate that TRU-016 ligation of the CD37 antigen causes recruitment and phosphorylation of SHP1 via a potential ITIM domain within the intracytplasmic domain...
  14. Monobody for Renal Inflammaton
    James W Larrick; Fiscal Year: 2011
    ..Inflammation has recently been shown to contribute to the decay of renal function. A novel antibody which inhibits inflammation by binding to FcaR1 will be developed as an immunotherapeutic for kidney disease. ..
  15. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..Understanding the mechanisms by which these factors enhance anti-viral immunity is essential to the development of novel strategies to delay onset and progression of HSV in at risk populations. ..
  16. Anna Huttenlocher; Fiscal Year: 2015
    ..specific signaling molecules that mediate neutrophil reverse migration, including the tyrosine phosphatase SHP1 that has been associated with autoinflammation...
  17. Regulation of the early events of platelet activation
    Lawrence F Brass; Fiscal Year: 2013
    ..A better understanding of this critical, but under-explored aspect of platelet biology is key to understanding and preventing what goes wrong when people have heart and strokes. ..
  18. Darrell J Irvine; Fiscal Year: 2016
    ..As a proof of concept, we will focus on delivery of a small-molecule inhibitor of the key T-cell phosphatase Shp1, which is a downstream target of a broad spectrum of negative regulatory signals in the tumor microenvironment ..
  19. Protective Factors Against the Development of Microvascular Complications
    Andrzej S Krolewski; Fiscal Year: 2012
    ....
  20. IMMUNODEFICIENCY AND TUMORIGENESIS
    Leonard Shultz; Fiscal Year: 2002
    ..This mutation is a null mutation within the hematopoietic cell phosphatase (Hcph) gene. Hcph encodes a cytoplasmic protein-tyrosine phosphatase termed SHP-1...
  21. Negative Regulatory Mechanisms for Myelin Specific T cells
    Brian D Evavold; Fiscal Year: 2013
    ..Two specific aims are designed to test this hypothesis. Aim 1: To define SHP-1 regulation in myelin reactive T cells- Aim 2: To determine the efficacy of MVP and adoptive T cell therapy in regulating autoimmune disease- ..
  22. Tumor-Induced Defective CTL Lytic Function
    Alan B Frey; Fiscal Year: 2010
    ....
  23. SH2 DOMAIN CONTAINING PTPASES SHP1 AND 2
    Tomas Mustelin; Fiscal Year: 1999
    ..one protein tyrosine phosphatase (PTPase), CD45, has so far been found to be important, while two other PTPases, SHP1 and SHP2, may participate...
  24. Angiotensin Receptor AT1 in Cardiovascular Cell Control.
    Tadashi Inagami; Fiscal Year: 2010
    ..abstract_text> ..
  25. Francesca Dominici; Fiscal Year: 2014
    ..Schrag, Alexander, Block) and Health Care Policy (HCP) at Harvard Medical School (HMS) (Dr. Normand)...
  26. Experiences of Family Members of Nursing Home Patients with Advanced Dementia
    Jane L Givens; Fiscal Year: 2013
    ..to describe HCP involvement in medical decision- making among 323 HCPs of NH residents with advanced dementia and to examine the ..
  27. Carole Ober; Fiscal Year: 2016
    ..how genetic variation in the LILRB receptors modulate the effects of HLA-G on both T cell phenotype and on the SHP1 and SHP2 signaling pathways that modulate airway smooth muscle hypertrophy in chronic asthma...
  28. Regulation of signaling in tumor infiltrating CD8+ T cells by Protocadherin-18
    Edwin J Vazquez-Cintron; Fiscal Year: 2011
    ....
  29. James C Paulson; Fiscal Year: 2016
    ..Thus, a deeper understanding of the basic immune processes studied in this project will aid in the development of novel therapeutic approaches infectious disease, chronic inflammatory disease and cancer. ..
  30. Role of SHP-1 in monocyte-mediated demyelination
    Paul T Massa; Fiscal Year: 2013
    ..The present project is thus focused on defining the essential role of SHP-1 in macrophage-mediated demyelinating disease. ..
  31. Patrick J Pagano; Fiscal Year: 2016
    ..This research plan is novel at al levels and has potential implications for the role of myriad other matricellular proteins in CVD. ..
  32. Yasuyoshi Ueki; Fiscal Year: 2014
    ....
  33. Janina P Lewis; Fiscal Year: 2016
    ..The major upregulated gene was hcp, which codes for a putative hydroxylamine reductase...
  34. BCR signaling during B cell development and maintenance
    MICHAEL CRAIG CARROLL; Fiscal Year: 2012
    ..abstract_text> ..
  35. Kerry S Campbell; Fiscal Year: 2014
    ....
  36. Norbert E Kaminski; Fiscal Year: 2016
    ..Finally, the proposed experiments will provide new knowledge concerning the fundamental role of the AHR in B cell immunobiology. ..
  37. Zeev Kain; Fiscal Year: 2015
    ..children's hospitals, each with a total of approximately 20 anesthesia and nursing health care providers (HCP) will examine the effectiveness of P-TIPS in preventing high anxiety and improving the recovery process in children ..
  38. PAUL MARTINETTI; Fiscal Year: 2014
    ..Aim 2 is to use interviews with expert health care professionals (HCP's) to design and create the FT communication interface, pilot testing it in our Sexual Medicine Clinic at UT M...
  39. Enhancing CD8 T Cell Function by Abrogating Inhibition by Regulatory Proteins
    Joseph N Blattman; Fiscal Year: 2010
    ....
  40. Tyrosine Phosphatase in Signal Transduction
    ZHIZHUANG ZHAO; Fiscal Year: 2007
    ..Our central hypothesis is that LAIR-1 and PZR play a maj or role in defining specificity of SHP 1 and SHP-2 and by using monoclonal anti-LAIR-1 and anti-PZR antibodies and membrane-permeable, tyrosine-..
  41. REGULATION OF INTERFERON ACTIVITY BY SHP-1 IN THE CNS
    PAUL MASSA; Fiscal Year: 2007
    ..We believe that information gained under these specific aims will elucidate mechanisms whereby SHP-1 controls virus infections in oligodendrocytes and perhaps other cells of the CNS. ..
  42. Renato V Iozzo; Fiscal Year: 2016
    ....
  43. Longitudinal DTI study in Children Treated for Congenital Hydrocephalus
    Weihong Yuan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Children with hydrocephalus (HCP) may suffer from significant brain injury resulting in concomitant functional and cognitive deficits...
  44. Dennis Ross-Degnan; Fiscal Year: 2014
    ..intervention tiers are as follows: 1) Tier 1 includes a comprehensive, individualized home care plan (HCP) reviewed by the medical service floor nurse with the patient prior to discharge;2) Tier 2 adds the electronic ..
  45. Deficiency of SHP-1 expression and function in multiple sclerosis
    Paul T Massa; Fiscal Year: 2010
    ..abstract_text> ..
  46. REGULATION OF B LYMPHOCYTE PROLIFERATION BY ANTIGEN
    Anthony L DeFranco; Fiscal Year: 2013
    ....
  47. Todd S Braver; Fiscal Year: 2016
    ..of the proposed project is its integration and synergistic relationship with the on-going Human Connectome Project (HCP), which will provide the most comprehensive characterization of normative human brain function and variation in the ..
  48. A Critical Role for SHP-1 in Retinal Degeneration
    Bonnie Lyons; Fiscal Year: 2006
    ..Such determinations will test the hypothesis that SHP- 1 is a critical signaling molecule necessary for the normal phagocytic function of the RPE. ..
  49. Pan Zheng; Fiscal Year: 2016
    ..initiated by HMGB1? Since SIglecG/10 has ITIM motifs in the cytoplasmic domain that was known to be associated with SHP1 and SHP2, we will test a hypothesis that SIglecG/10 is the signal transducer for CD24-mediated negative regulation...
  50. Inhibitory receptors in early B cell development
    Anne B Satterthwaite; Fiscal Year: 2013
    ....
  51. Heme Acquisition in Group A Streptococcus
    Benfang Lei; Fiscal Year: 2005
    ..Recently, we identified a novel heme-associated cell-surface protein (designated Shp1) made by GAS. The shp 1 gene is co-transcribed with 8 contiguous downstream genes, including spy1795, spy1794, and spy1793 encoding ..
  52. HLA-G - LILRB - SHP2 Axis in Airway Smooth Muscle
    Julian Solway; Fiscal Year: 2012
    ..In preliminary studies, we found that LILRB1, LILRB2, and their family member LILRB4, and SHP2 (but not SHP1) are all expressed in human ASM;that LILRB receptors activate SHP2 within human airway myocytes; and that SHP2 ..
  53. SHP-1/TYK2 INTERACTION AND ITS DEFECT IN FHLH DISEASE
    Taolin Yi; Fiscal Year: 2001
    ..These studies will make significant contributions toward achieving our long term objective of elucidating the physiological roles of SHP-1 in hematopoietic cells and defining its involvement of hematopoietic diseases. ..
  54. FUNCTION AND REGULATION OF SHP-1 TYROSINE PHOSPHATASE
    Terry Woodford Thomas; Fiscal Year: 1999
    ..Studies are proposed to further define the interaction. The studies proposed in this application will lay the foundations for development of pharmacological agents to modulate leukocyte activation and proliferation. ..
  55. Peter MacGarr Rabinowitz; Fiscal Year: 2014
    ..Prevention of occupational hearing loss and development of better tools to assess HCP effectiveness are top priorities of the National Occupational Research Agenda (NORA) for manufacturing...
  56. ANTIGEN-INDUCED B LYMPHOCYTE DEVELOPMENT
    Douglas Fearon; Fiscal Year: 2006
    ..abstract_text> ..
  57. Bruce R Rosen; Fiscal Year: 2014
    ..of this novel system, we will scan normal human subjects, including a number of subjects recruited from the other HCP site, and begin initial development of software to analyze this data and compare, document and disseminate the ..
  58. The role of PD-1 and SOCS-1 in HCV core/gC1qR-mediated IL-12 suppression
    Zhi Yao; Fiscal Year: 2009
    ..An understanding of these mechanisms will provide important information for the development of effective antiviral and vaccine strategies. ..
  59. Role of SOCS in Regulation of Transplantation Tolerance
    Stanislaw Stepkowski; Fiscal Year: 2004
    ..Such an approach will directly evaluate whether Stat5 or Stat6 activation is regulated by SOCS3 and/or other SOCS. These experiments will provide the first evidence for the role of SOCS in induction of transplantation tolerance. ..
  60. NEGATIVE REGULATION OF INTERLEUKIN-4 SIGNALING
    SAIKH HAQUE; Fiscal Year: 2004
    ..abstract_text> ..
  61. SHP1 Targeted Inhibition by Stibogluconate for Melanoma
    Ernest Borden; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  62. Expert Visual Guidance of Ultrasound for Telemedicine
    Florence Sheehan; Fiscal Year: 2006
    ..objective of this research is to develop an expert visual guidance system to direct rural health care providers (HCP) in acquiring diagnostic medical ultrasound images...
  63. The Transtheoretical Model and Health Care Proxies
    MARY JEZEWSKI; Fiscal Year: 2005
    ..Model (TTM) (stages of change, decisional balance, processes of change, self-efficacy) for health care proxy (HCP) completion, and developing models based on the relationships between the stages of change measure and the other ..
  64. REQUIRED REQUEST: DETERMINANTS OF FAMILY CONSENT
    Laura Siminoff; Fiscal Year: 1999
    ..Data collected will include interviews of 800 family members and 1,260 HCP respondents...
  65. Negative Regulation of Signal Transduction by G-CSF
    Fan Dong; Fiscal Year: 2006
    ..The proposed research will improve our understanding of the regulatory network of G-CSF signaling and the molecular mechanisms by which C- terminal truncation of the G-CSF receptor contribute to leukemogenesis. ..
  66. Function of the PRL Receptor Complex in Breast Cancer
    CHARLES CLEVENGER; Fiscal Year: 2006
    ..demonstrated that the complex of the transmembrane protein SHPS1 and the protein tyrosine phosphatases (PTP) SHP1 and SHP associate with the deltaS1 PRLr and undergo tyrosine phosphorylation following PRL stimulation...
  67. PRIMARY EPO SIGNALS FOR PROERYTHROID CELL EXPANSION
    Don Wojchowski; Fiscal Year: 2002
    ..Upstream effectors that dock at Epo-receptor complexes are relatively well defined (Jak2, Syp, HCP, STAT5, PLC-gamma, P13K, SHIP, Shc, Grb2, Crk-l, Cbl, Vav) and for many, links to mitogenic response pathways ..
  68. REGULATION AND SUBSTRATE SPECIFICITY OF SHP1 AND SHP2
    Guangwen Zhou; Fiscal Year: 2003
    ..The long-term goal of this proposal is to understand the fine-tuning regulatory functions of SHP-1 and SHP-2 on lymphocyte signaling. ..