SIRT1

Summary

Gene Symbol: SIRT1
Description: sirtuin 1
Alias: SIR2, SIR2L1, SIR2alpha, NAD-dependent protein deacetylase sirtuin-1, SIR2-like protein 1, regulatory protein SIR2 homolog 1, sirtuin type 1
Species: human

Top Publications

  1. ncbi Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    Anne Brunet
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Center for Blood Research CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 303:2011-5. 2004
  2. pmc Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell Metab 9:327-38. 2009
  3. ncbi hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
    H Vaziri
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 107:149-59. 2001
  4. ncbi Negative control of p53 by Sir2alpha promotes cell survival under stress
    J Luo
    Institute of Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Cell 107:137-48. 2001
  5. pmc SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
    V Byles
    Cancer Center and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Oncogene 31:4619-29. 2012
  6. ncbi Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
    Wen Yong Chen
    Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cell 123:437-48. 2005
  7. ncbi SIRT1 deacetylates and positively regulates the nuclear receptor LXR
    Xiaoling Li
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Mol Cell 28:91-106. 2007
  8. pmc Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    Fan Yeung
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    EMBO J 23:2369-80. 2004
  9. doi Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1
    Elhadji M Dioum
    Veterans Affairs North Texas Health Care System, Department of Medicine, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Science 324:1289-93. 2009
  10. doi Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha
    Ji Hong Lim
    Department of Pharmacology, Ischemic Hypoxic Disease Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Mol Cell 38:864-78. 2010

Research Grants

  1. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
  2. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2013
  3. JEFFREY SCOTT SMITH; Fiscal Year: 2014
  4. The role of the deacetylase Sirt1 in the maintenance of adult neural stem cells
    VICTORIA RAFALSKI; Fiscal Year: 2010
  5. Ivona Percec; Fiscal Year: 2016
  6. Shin Ichiro Imai; Fiscal Year: 2016
  7. Leonard P Guarente; Fiscal Year: 2016
  8. Not Only SIRT1: A Role for Nuclear SIRT6 in Circadian Control
    Paolo Sassone-Corsi; Fiscal Year: 2013
  9. FASEB SRC on HDACs, Sirtuins and Reversible Acetylation in Signaling and Disease
    Scott W Hiebert; Fiscal Year: 2013
  10. David A Sinclair; Fiscal Year: 2016

Detail Information

Publications322 found, 100 shown here

  1. ncbi Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    Anne Brunet
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Center for Blood Research CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 303:2011-5. 2004
    ..We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control the cellular response to stress by regulating the FOXO family of Forkhead transcription factors,..
  2. pmc Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell Metab 9:327-38. 2009
    ..b>SIRT1, a NAD+-dependent protein deacetylase, is an important regulator of energy homeostasis in response to nutrient ..
  3. ncbi hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
    H Vaziri
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 107:149-59. 2001
    ..We show here that the protein product of the gene hSIR2(SIRT1), the human homolog of the S...
  4. ncbi Negative control of p53 by Sir2alpha promotes cell survival under stress
    J Luo
    Institute of Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Cell 107:137-48. 2001
    ..Here, we show that mammalian Sir2alpha physically interacts with p53 and attenuates p53-mediated functions...
  5. pmc SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
    V Byles
    Cancer Center and Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Oncogene 31:4619-29. 2012
    ..we propose a novel mechanism through which the nicotinamide adenine dinucleotide-dependent histone deacetylase SIRT1 regulates EMT in prostate cancer cells through cooperation with the EMT inducing transcription factor ZEB1...
  6. ncbi Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
    Wen Yong Chen
    Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cell 123:437-48. 2005
    ..by which the loss of HIC1 function promotes tumorigenesis is via activating the stress-controlling protein SIRT1 and thereby attenuating p53 function...
  7. ncbi SIRT1 deacetylates and positively regulates the nuclear receptor LXR
    Xiaoling Li
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Mol Cell 28:91-106. 2007
    The NAD(+)-dependent deacetylase Sir2 regulates life span in lower eukaryotes. The mammalian ortholog SIRT1 regulates physiological processes including apoptosis, fat metabolism, glucose homeostasis, and neurodegeneration...
  8. pmc Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    Fan Yeung
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    EMBO J 23:2369-80. 2004
    ..In this study, we demonstrate that SIRT1, a nicotinamide adenosine dinucleotide-dependent histone deacetylase, regulates the transcriptional activity of NF-..
  9. doi Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1
    Elhadji M Dioum
    Veterans Affairs North Texas Health Care System, Department of Medicine, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Science 324:1289-93. 2009
    ..We demonstrate that Sirtuin 1 (Sirt1), a redox-sensing deacetylase, selectively stimulates activity of the transcription factor hypoxia-inducible ..
  10. doi Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha
    Ji Hong Lim
    Department of Pharmacology, Ischemic Hypoxic Disease Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Mol Cell 38:864-78. 2010
    To survive in hypoxic environments, organisms must be able to cope with redox imbalance and oxygen deficiency. The SIRT1 deacetylase and the HIF-1alpha transcription factor act as redox and oxygen sensors, respectively...
  11. pmc Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands
    Heather M O'Hagan
    Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Cell 20:606-19. 2011
    ..Thus, oxidative damage induces formation and relocalization of a silencing complex that may explain cancer-specific aberrant DNA methylation and transcriptional silencing...
  12. doi NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response
    B Wang
    Department of Cancer Biology, City of Hope, Duarte, CA, USA
    Oncogene 30:907-21. 2011
    ..NAMPT has crucial roles for many cellular functions by regulating NAD(+)-dependent SIRT1 deacetylase. However, roles of NAMPT in cancer are poorly defined...
  13. doi MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1
    Rossella Menghini
    Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Circulation 120:1524-32. 2009
    ..miR-217 regulates the expression of silent information regulator 1 (SirT1), a major regulator of longevity and metabolic disorders that is progressively reduced in multiple tissues during ..
  14. pmc Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
    Jonathan M Solomon
    Elixir Pharmaceuticals, Inc, One Kendall Square, Cambridge, MA 02139, USA
    Mol Cell Biol 26:28-38. 2006
    Human SIRT1 is an enzyme that deacetylates the p53 tumor suppressor protein and has been suggested to modulate p53-dependent functions including DNA damage-induced cell death...
  15. doi Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis
    Isabelle Gorenne
    University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Circulation 127:386-96. 2013
    ..Sirtuin 1 deacetylase (SIRT1) regulates cell ageing and energy metabolism and regulates the DNA damage response through multiple targets...
  16. pmc Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
    Qing Jun Zhang
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, PR China
    Cardiovasc Res 80:191-9. 2008
    ..Recent studies suggest that class III deacetylase SIRT1 may promote cell survival via novel antioxidative mechanisms...
  17. pmc Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
    Lydia Kriegl
    Department of Pathology, Ludwig Maximilians University LMU, Munich Germany
    Oncotarget 3:1182-93. 2012
    ..Here, we investigate the expression of the c-MYC oncogene and the SIRT1 protein deacetylase by immunohistochemical staining in subgroups of colorectal serrated lesions that were ..
  18. ncbi Mammalian SIRT1 represses forkhead transcription factors
    Maria Carla Motta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 116:551-63. 2004
    ..elegans. Here we show that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead ..
  19. ncbi Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    Haim Y Cohen
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Science 305:390-2. 2004
    ..Here we show that expression of mammalian Sir2 (SIRT1) is induced in CR rats as well as in human cells that are treated with serum from these animals...
  20. pmc SIRT1 regulates the function of the Nijmegen breakage syndrome protein
    Zhigang Yuan
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Mol Cell 27:149-62. 2007
    ..Here, we report that NBS1 is an acetylated protein and that the acetylation level is tightly regulated by the SIRT1 deacetylase...
  21. ncbi SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
    Shino Nemoto
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 280:16456-60. 2005
    ..Here we have examined the cellular effects of overexpression of SIRT1, the closest mammalian ortholog of Sir2...
  22. ncbi Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity
    Jyothish B Pillai
    Department of Cardiothoracic Surgery, University of Chicago, IL 60637, USA
    J Biol Chem 280:43121-30. 2005
    ..Here, we show that depletion of myocyte NAD levels and the subsequent reduction of Sir2alpha deacetylase activity are the sequential steps contributing to PARP-mediated myocyte cell death...
  23. ncbi SIRT1 is significantly elevated in mouse and human prostate cancer
    Derek M Huffman
    Division of Physiology and Metabolism, Department of Nutrition Sciences, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
    Cancer Res 67:6612-8. 2007
    Evidence suggests that the histone deacetylase, SIRT1, is a mediator of life span extension by calorie restriction; however, SIRT1 may paradoxically increase the risk of cancer...
  24. pmc Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island
    Heather M O'Hagan
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
    PLoS Genet 4:e1000155. 2008
    ..to the site of damage of key proteins involved in establishing and maintaining transcriptional repression, namely SIRT1, EZH2, DNMT1, and DNMT3B, and the appearance of the silencing histone modifications, hypoacetyl H4K16, H3K9me2 and ..
  25. pmc The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling
    Rui Chen
    Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas, TX 75216, USA
    J Biol Chem 287:30800-11. 2012
    ..CBP acetylates HIF-2α, is a major coactivator for HIF-2-mediated Epo induction, and is required for Sirt1 augmentation of HIF-2 signaling during hypoxia in Hep3B cells...
  26. doi Sirt1 deacetylates c-Myc and promotes c-Myc/Max association
    Beibei Mao
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    Int J Biochem Cell Biol 43:1573-81. 2011
    ..b>Sirt1, a NAD-dependent class III histone deacetylase, has a paradoxical role in tumorigenesis by deacetylating several ..
  27. doi SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells
    Yi Zu
    Department of Pharmacology, University of Hong Kong, Hong Kong, China
    Circ Res 106:1384-93. 2010
    ..b>SIRT1 is a conserved NAD(+)-dependent deacetylase possessing beneficial effects against aging-related diseases, despite ..
  28. doi Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth
    Juan Chen
    The State Key Laboratory in Oncology in South China, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Cancer Res 71:4138-49. 2011
    ..Sirtuin 1 (SIRT1) is a class III histone deacetylase that is implicated in gene regulations and stress resistance...
  29. pmc The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
    Ron Firestein
    Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2020. 2008
    ..The Sir2/SIRT1 family of NAD(+)-dependent deacetylases is proposed to underlie the health benefits of calorie restriction (CR), a ..
  30. pmc Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
    Rui Hong Wang
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 14:312-23. 2008
    ..Here we mutated the Sirt1 gene, a homolog of yeast Sir2, in mice to study its function...
  31. doi Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection
    Laia Bosch-Presegué
    Chromatin Biology Laboratory, Cancer Epigenetics and Biology Program, Institut d Investigacio Biomedica de Bellvitge, Avinguda Gran Via de l Hospitalet 199 203, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Mol Cell 42:210-23. 2011
    ..The Sirtuin SirT1 is involved in facultative heterochromatin formation through an intimate functional relationship with the H3K9me3 ..
  32. doi MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1
    Laisheng Li
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, 651 East Dong Feng Road, Guangzhou 510060, People s Republic of China
    Clin Exp Med 13:109-17. 2013
    ..of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1. We examined miR-34a levels in breast cancer cell lines and breast cancer specimens by qRT-PCR...
  33. doi A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
    Yuji Nakamaru
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    FASEB J 23:2810-9. 2009
    ..increase of MMP9 expression, and here we show that oxidative stress-dependent reduction of a protein deacetylase, SIRT1, known as a putative antiaging enzyme, causes elevation of MMP9 expression...
  34. pmc SIRT1 genetic variation is related to BMI and risk of obesity
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:2828-34. 2009
    b>SIRT1 has pleiotropic metabolic functions. We investigated whether SIRT1 genetic variation is associated with obesity.
  35. doi MicroRNA-34a regulation of endothelial senescence
    Takashi Ito
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, West Henrietta, NY 14586, USA
    Biochem Biophys Res Commun 398:735-40. 2010
    ..Searching for how miR-34a affects senescence, we discovered that SIRT1 is a target of miR-34a...
  36. pmc Serum withdrawal up-regulates human SIRT1 gene expression in a p53-dependent manner
    Linshan Shang
    Key Laboratory for Experimental Teratology of the Ministry of Education and Institute of Medical Genetics, Shandong University School of Medicine, Jinan, Shandong, China
    J Cell Mol Med 13:4176-84. 2009
    b>SIRT1, a nicotinamide adenine dinucleotide (NAD(+))-dependent histone/protein deacetylase, has been extensively studied recently for its critical role in the regulation of physiology, calorie restriction and aging...
  37. ncbi SIRT1 as a novel potential treatment target for vascular aging and age-related vascular diseases
    F Wang
    State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, New Building 507, Beijing, 100005, People s Republic of China
    Curr Mol Med 13:155-64. 2013
    ..Mammalian Sir2 (SIRT1, a NAD+-dependent deacetylase), previously shown to extend the lifespan of lower organisms, is a promising target ..
  38. pmc SIRT1 polymorphism, long-term survival and glucose tolerance in the general population
    Sylwia M Figarska
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 8:e58636. 2013
    ..b>SIRT1, the human homolog of Sir2, that controls numerous physiological processes including the glucose metabolism, is ..
  39. doi STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation
    Rosanna Sestito
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Via Monti di Creta, 104, 00167 Rome, Italy
    FASEB J 25:916-27. 2011
    ..Due to the opposite effects of IL-22 and SIRT1, we investigated whether IL-22-induced effects in keratinocytes could be regulated by SIRT1 through control of ..
  40. doi Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor receptor activation
    M L Balestrieri
    Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via L De Crecchio 7, Naples 80138, Italy
    Diabetologia 56:162-72. 2013
    ..short-term exposure to high glucose concentrations relates to reduced activity of silent information regulator 1 (SIRT1) and increased synthesis of platelet-activating factor (PAF)...
  41. ncbi Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1
    Fei Chu
    Department of Pediatrics, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
    Cancer Res 65:10183-7. 2005
    ..We report that expression of the longevity gene sirt1 increased both at the RNA and protein levels in all the five drug-resistant cell lines tested when compared with ..
  42. doi Expression and prognostic significance of SIRT1 in ovarian epithelial tumours
    Kyu Yun Jang
    Department of Pathology, Medical School and Institute for Medical Sciences, Chonbuk National University, Dukjin Gu, Jeonju, Jeonbuk, Republic of Korea
    Pathology 41:366-71. 2009
    Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase...
  43. doi Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index
    M Carola Zillikens
    Department of Internal Medicine, Room D428, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Clin Nutr 91:1387-93. 2010
    Genetic variation in SIRT1 has been associated with body mass index (BMI) and risk of obesity. SIRT1 may be influenced by diet.
  44. pmc Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity
    Stephen J Clark
    Department of Genomics of Common Diseases, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK
    Obesity (Silver Spring) 20:178-85. 2012
    Recent studies have reported associations of sirtuin 1 (SIRT1) single nucleotide polymorphisms (SNPs) to both obesity and BMI. This study was designed to investigate association between SIRT1 SNPs, SIRT1 gene expression and obesity...
  45. doi Expression of SIRT1 in gastric cardiac cancer and its clinicopathologic significance
    An Ning Feng
    Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, China
    Int J Surg Pathol 19:743-50. 2011
    b>SIRT1 is a deacetylase that modifies gene expression. Some researchers have found that SIRT1 is upregulated in malignant tumor tissues...
  46. pmc SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians
    Yan Dong
    Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
    Mol Genet Metab 104:661-5. 2011
    Genetic variation in SIRT1 affects obesity-related phenotypes in several populations...
  47. pmc SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages
    Ran Zhang
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    J Biol Chem 285:7097-110. 2010
    SIRT1 (Sirtuin type 1), a mammalian orthologue of yeast SIR2 (silent information regulator 2), has been shown to mediate a variety of calorie restriction (CR)-induced physiological events, such as cell fate regulation via deacetylation of ..
  48. pmc SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
    Kimberly R Holloway
    Department of Molecular and Cellular Physiology, School of Medicine, and Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Proc Natl Acad Sci U S A 107:9216-21. 2010
    Sirtuin 1 (SIRT1) is a class III histone deacetylase that deacetylates histone and nonhistone proteins to regulate gene transcription and protein function...
  49. pmc SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer
    Selvakumar Elangovan
    Department of Biochemistry, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia, USA
    Cancer Res 71:6654-64. 2011
    The NAD-dependent histone deacetylase silent information regulator 1 (SIRT1) is overexpressed and catalytically activated in a number of human cancers, but recent studies have actually suggested that it may function as a tumor suppressor ..
  50. pmc Janus-faced role of SIRT1 in tumorigenesis
    Na Young Song
    Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea
    Ann N Y Acad Sci 1271:10-9. 2012
    Silent mating type information regulation 1 (Sirtuin 1; SIRT1) has been reported to regulate various physiological events, such as aging and metabolism, via deacetylation of histone and nonhistone proteins...
  51. pmc Inhibition of transcriptional activity of c-JUN by SIRT1
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 376:793-6. 2008
    ..b>SIRT1 (Sirtuin 1) is a histone deacetylase that controls gene transcription through modification of chromatin structure...
  52. doi Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells
    Alexander Breitenstein
    Cardiovascular Research, Physiology Institute, University of Zurich, 8057 Zurich, Switzerland
    Cardiovasc Res 89:464-72. 2011
    The mammalian silent information regulator-two 1 (Sirt1) blunts the noxious effects of cardiovascular risk factors such as type 2 diabetes mellitus and obesity...
  53. pmc Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
    Mei Ming
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:22623-8. 2010
    ..Here we show that inhibition of the deacetylase and longevity factor SIRT1 impairs global genome NER through suppressing the transcription of XPC in a SIRT1 deacetylase-dependent manner...
  54. doi Deacetylation of cortactin by SIRT1 promotes cell migration
    Y Zhang
    Department of Pathology and Cell Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Oncogene 28:445-60. 2009
    ..Mouse embryo fibroblasts (MEFs) lacking sir2alpha (the mouse homolog of SIRT1) migrated more slowly than did wild-type cells...
  55. doi SIRT1 acts as a modulator of neointima formation following vascular injury in mice
    Li Li
    National Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, No 5 Dong Dan San Tiao, Beijing 100005, People s Republic of China
    Circ Res 108:1180-9. 2011
    ..Sirtuin 1 (SIRT1), a class III histone deacetylase (HDAC), has been reported to have the function of antiatherosclerosis, but its ..
  56. pmc Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
    Ling Li
    Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA
    Cancer Cell 21:266-81. 2012
    ..Thus, strategies targeting LSC are required to achieve cure. We show that the NAD(+)-dependent deacetylase SIRT1 is overexpressed in human CML LSC...
  57. doi Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells
    Hidetaka Ota
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Arterioscler Thromb Vasc Biol 28:1634-9. 2008
    ..The purpose of the present study was to clarify the molecular mechanisms underlying the preventive effect of treatment with cilostazol on oxidative stress-induced premature senescence in human endothelial cells...
  58. doi SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis
    Minakshi Nihal
    Department of Dermatology University of Wisconsin School of Medicine and Public Health Madison, WI USA Paul P Carbone Comprehensive Cancer Center University of Wisconsin School of Medicine and Public Health Madison, WI USA
    Cell Cycle 13:632-40. 2014
    Silent information regulator type-1 (SIRT1) is the best-studied member of the Sirtuin (Sir2) family of nicotinamide dinucleotide (NAD)-dependent class III histone deacetylases (HDACs), but has not yet been explored in cutaneous T-cell ..
  59. doi p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence
    Seok Young Jang
    School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 702 701, Republic of Korea
    FEBS Lett 585:3360-6. 2011
    ..This acetylation event was suppressed by SIRT1 activation. CKIIα and CKIIβ were co-immunoprecipitated with SIRT1 in a p53-independent manner...
  60. pmc Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
    Frederic Picard
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 429:771-6. 2004
    ..Here we show that the mammalian SIR2 orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie restriction in mammals; that is, fat mobilization in white ..
  61. doi SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma
    Kyu Yun Jang
    Department of Pathology, Chonbuk National University Medical School, Institute for Medical Sciences, Jeonju, Republic of Korea
    Am J Surg Pathol 32:1523-31. 2008
    Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, it is suggested that SIRT1 may be involved in the development of malignant tumors including mouse lymphoma...
  62. pmc SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
    Jarno Rutanen
    Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Diabetes 59:829-35. 2010
    Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents...
  63. doi SIRT1 variants are associated with aging in a healthy Han Chinese population
    Wei Guang Zhang
    Department of Gerontology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
    Clin Chim Acta 411:1679-83. 2010
    Aging is influenced by diverse environmental and genetic risk factors. The SIRT1 (silent information regulator 1) gene has been shown to regulate lifespan and aging in previous studies...
  64. doi SIRTUIN 1 gene polymorphisms are associated with cholesterol metabolism and coronary artery calcification in Japanese hemodialysis patients
    Yasuhiko Shimoyama
    Department of Advanced Medicine for Uremia, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    J Ren Nutr 22:114-9. 2012
    Sirtuin 1 (SIRT1), a longevity gene, protects cells against oxidative and genotoxic stress...
  65. doi SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
    D Herranz
    Tumor Suppression Group, Spanish National Cancer Research Center CNIO, Madrid, Spain
    Oncogene 32:4052-6. 2013
    Current genetic evidence in mice indicates that SIRT1 has potent tumor suppressor activity in a variety of cancer models, with no evidence yet for SIRT1 oncogenic activity in vivo...
  66. pmc SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells
    Jenna D Lovaas
    Cancer Research Center and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Prostate 73:522-30. 2013
    ..b>SIRT1 is a nicotinamide adenine dinucleotide-dependent histone deacetylase (class III HDAC) that has recently been shown ..
  67. pmc The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population
    Ekta Rai
    National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    PLoS ONE 7:e48621. 2012
    ..Recent literature on the role of SIRT1 as a potential master switch modulating insulin secretion and regulating gene expression in pancreatic β cells ..
  68. doi Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation
    Brendan C Dickson
    Department of Pathology, University of Toronto, Ontario, Canada M5S 1A8
    Hum Pathol 44:1125-30. 2013
    Sirtuin, silent mating-type information regulation 2 homolog Saccharomyces cerevisiae 1 (SIRT1), is a protein that has been implicated in multiple mammalian functions including cell aging, stress resistance, and differentiation...
  69. pmc High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma
    Albrecht Stenzinger
    Institute of Pathology, and National Center for Tumor Diseases NCT, University Hospital Heidelberg, Heidelberg, Germany
    BMC Cancer 13:450. 2013
    Several lines of evidence indicate that Sirt1, a class III histone deacetylase (HDAC) is implicated in the initiation and progression of malignancies and thus gained attraction as druggable target...
  70. ncbi Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells
    Yuning Sun
    Beijing Institute of Radiation Medicine, 27 Taiping Road, Hai Dian District, Beijing 100850, China
    Lung Cancer 58:21-9. 2007
    b>Sirt1, a conserved nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, has been implicated in modulating transcriptional silencing and cell survival, and seems to play a key role in carcinogenesis through deacetylation of ..
  71. ncbi Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
    Eun Joo Kim
    Department of Bioscience and Biotechnology, Sejong University, 98 Kunja dong, Kwangjin gu, Seoul 143 747, Korea
    Mol Cell 28:277-90. 2007
    Human SIRT1 is an NAD+-dependent deacetylase protein that plays a role in cell death/survival, senescence, and endocrine signaling. While its substrates, including p53, have been well characterized, no direct regulators are known...
  72. pmc Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?
    Brittney Jung-Hynes
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 284:3823-32. 2009
    ..Employing in vitro and in vivo approaches, in this study, we tested the hypothesis that SIRT1, which belongs to the Sir2 (silent information regulator 2) family of sirtuin class III histone deacetylases, is ..
  73. doi Sirtuin 1 in malignant transformation: friend or foe?
    Yujiang Fang
    Department of Surgery, University of Missouri School of Medicine, Columbia, 65212, USA
    Cancer Lett 306:10-4. 2011
    In the past decade, great interest has been shown in the role of sirtuin 1 (SIRT1) in tumorigenesis. The published data show SIRT1 can function as both a tumor promoter and tumor suppressor...
  74. doi Expression and role of SIRT1 in hepatocellular carcinoma
    Ha Na Choi
    Department of Pathology, Chonbuk National University, Medical School, Jeonju, Republic of Korea
    Oncol Rep 26:503-10. 2011
    Silent mating type information regulation 2 homolog 1 (SIRT1) is a multifaceted, nicotinamide adenine dinucleotide-dependent protein deacetylase with involvement in a wide variety of cellular processes ranging from cancer to aging...
  75. doi The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy
    Nagalingam R Sundaresan
    Department of Surgery, Committee on Cellular and Molecular Physiology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Sci Signal 4:ra46. 2011
    ..Deacetylation by SIRT1 enhanced binding of Akt and PDK1 to PIP(3) and promoted their activation...
  76. doi Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
    Kai Li
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 283:7590-8. 2008
    ..Mammalian Sir2 (SIRT1) has also been found to regulate premature cellular senescence induced by the tumor suppressors PML and p53...
  77. pmc SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation
    Fan Lan
    Diabetes and Metabolism Research Unit, Department of Medicine, Section of Endocrinology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 283:27628-35. 2008
    b>SIRT1, a histone/protein deacetylase, and AMP-activated protein kinase (AMPK) are key enzymes responsible for longevity and energy homeostasis...
  78. ncbi Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
    Kevin J Bitterman
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:45099-107. 2002
    ..A human homologue of Sir2, SIRT1, regulates the activity of the p53 tumor suppressor and inhibits apoptosis...
  79. pmc Inhibition of SUV39H1 methyltransferase activity by DBC1
    Zhenyu Li
    Department of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 284:10361-6. 2009
    ..SUV39H1 forms a complex with SirT1, and its activity is stimulated by SirT1 binding...
  80. doi Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX
    Kazutsune Yamagata
    Department of Molecular Oncology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 390:1355-60. 2009
    b>Sirt1 appear to be NAD(+)-dependent deacetylase that deacetylates histones and several non-histone proteins...
  81. ncbi Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing
    Tadahiro Shimazu
    Chemical Genetics Laboratory, Discovery Research Institute, RIKEN, Wako, Saitama 351 0198, Japan
    J Biol Chem 282:4470-8. 2007
    ..Whereas CBP acetylated these proteins, HDAC1, HDAC3, HDAC10, SIRT1, and SIRT2 were involved in in vivo deacetylation...
  82. doi A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
    Keitaro Kojima
    Department of Urology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, Gifu 501 1193, Japan
    Biochem Biophys Res Commun 373:423-8. 2008
    b>SIRT1, which belongs to the family of type III histone deacetylase, is implicated in diverse cellular processes...
  83. doi Epigenetic control of rDNA loci in response to intracellular energy status
    Akiko Murayama
    Graduate School of Life and Environmental Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8572, Japan
    Cell 133:627-39. 2008
    ..eNoSC contains Nucleomethylin, which binds histone H3 dimethylated Lys9 in the rDNA locus, in a complex with SIRT1 and SUV39H1...
  84. doi Nicotinamide phosphoribosyltransferase/sirtuin 1 pathway is involved in human immunodeficiency virus type 1 Tat-mediated long terminal repeat transactivation
    Hong Sheng Zhang
    College of Life Science and Bioengineering, Beijing University of Technology, Pingleyuan 100, District of Chaoyang, Beijing 100124, China
    J Cell Biochem 110:1464-70. 2010
    ..activity is controlled by nicotinamide adenine nucleotide(+) (NAD(+))-dependent deacetylase sirtuin 1 (SIRT1)...
  85. ncbi Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
    Takehiko Takata
    Laboratory of Molecular and Cellular Assembly, Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    Biochem Biophys Res Commun 301:250-7. 2003
    ..Here we demonstrate that the human Sir2 homologue, SIRT1, also physically associates with the human bHLH repressor proteins, hHES1 and hHEY2, both in vitro and in vivo...
  86. pmc Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression
    Thanaset Senawong
    Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences, College of Pharmacy, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon 97331, USA
    J Biol Chem 278:43041-50. 2003
    ..The human homolog of yeast Sir2, SIRT1, was found to interact directly with CTIP2 and was recruited to the promoter template in a CTIP2-dependent manner...
  87. ncbi FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)
    Armando van der Horst
    Department of Physiological Chemistry, Center for Biomedical Genetics, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Biol Chem 279:28873-9. 2004
    ..Deacetylation of FOXOs involves binding of the NAD-dependent deacetylase hSir2(SIRT1)...
  88. pmc Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation
    Andrei Kuzmichev
    Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 102:1859-64. 2005
    ..formation of a previously undescribed PRC complex, PRC4, that contains the NAD+-dependent histone deacetylase SirT1 and isoform 2 of the PRC component Eed...
  89. ncbi Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
    Chuangui Wang
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Nat Cell Biol 8:1025-31. 2006
    ..The mammalian homologue of Sir2 (SirT1) regulates p53, NF-kappaB and Forkhead transcription factors, and is implicated in stress response...
  90. ncbi SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity
    Jin Ming Dai
    Beijing Institute of Radiation Medicine, Beijing, China
    J Cell Physiol 210:161-6. 2007
    ..Moreover, SIRT1 binds to p53 while repressing the expression of their target genes...
  91. ncbi Sirtuin functions in health and disease
    Hiroyasu Yamamoto
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, Boite Postale 10142, 67404 Illkirch, France
    Mol Endocrinol 21:1745-55. 2007
    ..The mammalian sirtuins SIRT1-SIRT7 are implicated in a variety of cellular functions ranging from gene silencing, over the control of the cell ..
  92. ncbi SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
    Alejandro Vaquero
    Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Jersey 08854, USA
    Nature 450:440-4. 2007
    ..Sirtuin 1 (SIRT1) and suppressor of variegation 3-9 homologue 1 (SUV39H1) are amongst the enzymes responsible for chromatin ..
  93. pmc SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity
    Swami R Narala
    Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada
    Mol Biol Cell 19:1210-9. 2008
    b>SIRT1, the mammalian homolog of SIR2 in Saccharomyces cerevisiae, is an NAD-dependent deacetylase implicated in regulation of lifespan...
  94. doi Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression
    Kazuhiro Hasegawa
    Department of Internal Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 1608582, Japan
    Biochem Biophys Res Commun 372:51-6. 2008
    NAD(+)-dependent protein deacetylase Sirt1 regulates cellular apoptosis...
  95. pmc TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1
    Marina Cardellini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetes 58:2396-401. 2009
    ..We tested its association with atherosclerosis in subjects with type 2 diabetes and identified Sirtuin 1 (SirT1) as a major regulator of TIMP3 expression.
  96. pmc Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation
    Yuan Bin Xie
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 284:28762-74. 2009
    ..Interestingly, the repression of SMILE on ERRgamma is released by SIRT1 inhibitors, a catalytically inactive SIRT1 mutant, and SIRT1 small interfering RNA but not by histone protein ..
  97. ncbi Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
    R A Frye
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15240, USA
    Biochem Biophys Res Commun 260:273-9. 1999
    ..Here five human sirtuin cDNAs are characterized. The SIRT1 sequence has the closest homology to the S. cerevisiae Sir2p...
  98. ncbi Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    Konrad T Howitz
    BIOMOL Research Laboratories, Inc, 5120 Butler Pike, Plymouth Meeting, Pennsylvania 19462, USA
    Nature 425:191-6. 2003
    ..Included in this family are SIR-2.1, a Caenorhabditis elegans enzyme that regulates lifespan, and SIRT1, a human deacetylase that promotes cell survival by negatively regulating the p53 tumour suppressor...
  99. ncbi Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
    Alejandro Vaquero
    Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Mol Cell 16:93-105. 2004
    We characterized human SirT1, one of the human homologs of the budding yeast Sir2p, an NAD+-dependent histone deacetylase involved in establishing repressive chromatin and increased life span...
  100. ncbi SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
    Toula Bouras
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Rd, Washington, DC 20057, USA
    J Biol Chem 280:10264-76. 2005
    ..b>SIRT1, the closest mammalian ortholog of the yeast SIR2 (silent information regulator 2) gene, represses several ..
  101. ncbi FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    Yukari Ido Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, Columbia University, New York, New York 10032, USA
    Cell Metab 2:153-63. 2005
    ..stress by forming a complex with the promyelocytic leukemia protein Pml and the NAD-dependent deacetylase Sirt1 to activate expression of NeuroD and MafA, two Insulin2 (Ins2) gene transcription factors...

Research Grants68

  1. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
    ..The mammalian homolog SIRT1, deacetylates FOXO1, thus shifting FOXO-dependent responses away from cell death and towards cell survival...
  2. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2013
    ..founding member yeast Sir2 (ySir2, yeast silent information regulator 2) which is equivalent to human sirtuin1 (SIRT1) is essential for maintaining silent chromatin via the deacetylation of histones and non-histone proteins...
  3. JEFFREY SCOTT SMITH; Fiscal Year: 2014
    ..between Sir2 and RNA, and to determine the level of conservation with sirtuins from other species such as human SIRT1, the closest ortholog to yeast Sir2...
  4. The role of the deacetylase Sirt1 in the maintenance of adult neural stem cells
    VICTORIA RAFALSKI; Fiscal Year: 2010
    ..One member of this family, Sirt1, has recently been implicated in a wide range of cellular processes, including cell survival and inhibition of ..
  5. Ivona Percec; Fiscal Year: 2016
    ..that the sirtuin genes contribute significantly to adipose tissue aging and found in my preliminary studies that SIRT1, SIRT3, SIRT6, and SIRT7 are differentially expressed in aging adipose tissue...
  6. Shin Ichiro Imai; Fiscal Year: 2016
    ..Our new study has recently demonstrated a novel function of the mammalian SIR2 ortholog SIRT1 in the hypothalamus, particularly in the dorsomedial and lateral hypothalamic nuclei (DMH and LH, respectively), ..
  7. Leonard P Guarente; Fiscal Year: 2016
    ..In mammals, there are seven sirtuins termed SIRT1-7. Three (SIRT1, 6, and 7) are primarily nuclear, three (SIRT3-5) are mitochondrial and SIRT2 is cytoplasmic...
  8. Not Only SIRT1: A Role for Nuclear SIRT6 in Circadian Control
    Paolo Sassone-Corsi; Fiscal Year: 2013
    ..Accumulating evidence has implicated the histone deacetylase SIRT1 in circadian regulation, a key discovery since this enzyme utilizes NAD+ as coenzyme, thereby linking energy ..
  9. FASEB SRC on HDACs, Sirtuins and Reversible Acetylation in Signaling and Disease
    Scott W Hiebert; Fiscal Year: 2013
    ..With the identification, isolation, cloning and functional characterization of 18 human HDACs (HDAC1- 11 and SIRT1-7) and many acetyltransferases in the past decade, the coming years will see a continued dramatic expansion in our ..
  10. David A Sinclair; Fiscal Year: 2016
    ..There are seven mammalian sirtuins, SIRT1-7. SIRT1 is the best studied...
  11. Sirtuins in Glaucomatous Optic Neuropathy
    Robert N Weinreb; Fiscal Year: 2013
    ABSTRACT This proposal addresses the idea that activation of sirtuin-1 (Sirt1), a deacetylase that can regulate gene expression, will increase retinal ganglion cell (RGC) survival and visual system function in glaucoma...
  12. High-throughput assays for the development of SIRT5-specific inhibitors
    Hening Lin; Fiscal Year: 2012
    ..Humans have seven sirtuins, SIRT1-7, that have been shown to regulate a variety of biological processes, including aging, transcription, and ..
  13. Marcia Haigis; Fiscal Year: 2014
    ..Mammals have seven Sir2 homologs (sirtuins;SIRT1-7), which regulate distinct aspects of metabolism...
  14. Bruce R Troen; Fiscal Year: 2014
    ..and SRT1720 are synthetic resveratrol mimetics (SyRMs) that were designed to specifically activate sirtuin1 (Sirt1), but an increasing number of reports suggest that RSV and SyRMs act on targets other than Sirt1...
  15. Dimitri Krainc; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Sirt1, an NAD-dependent protein deacetylase has emerged as important regulator of mammalian transcription in response to cellular metabolic status and stress...
  16. Raul Mostoslavsky; Fiscal Year: 2014
    ..Seven mammalian Sir2 homologs have been found (SIRT1-7), but their functions remain to be fully elucidated...
  17. Leonard P Guarente; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): We plan to further the study of the function of SIRT1 in mice. In Aim 1 we study whether SIRT1 (and other sirtuin) activity declines aging...
  18. SIRT1 Overexpression in Cellular Mitochondrial Metabolism and Function
    James Russell; Fiscal Year: 2009
    ..b>SIRT1 is a member of the sirtuin family of NAD+dependent deacetylases, which is proposed to be responsible for health ..
  19. The Role of SIRT6 in Modulating Circadian Gene Expression
    Selma Masri; Fiscal Year: 2012
    ..Of particular importance, SIRT1 is responsible for deacetylation and regulation of BMAL1, as well as deacetylation of H3 lysine 9/14 at circadian ..
  20. Srinivasan V Narayanan; Fiscal Year: 2014
    ..C[unreadable] (PKC[unreadable]) and sirtuins (family of protein/histone deacetylases), specifically sirtuin 1 (SIRT1), following IPC;(2) Determine the mechanism(s) of Nrf2-mediated neuroprotection, primarily its effects on synaptic ..
  21. Novel Role for Sirtuin Signaling Mechanisms and Downstream Targets in Depression
    Deveroux Ferguson; Fiscal Year: 2013
    ..The objectives of this program of research are to evaluate the role of SIRT1 and its downstream targets as potential new candidates for the treatment of neuropsychiatric disorders by ..
  22. Stephen D Anton; Fiscal Year: 2014
    ..e. SIRT1 and SIRT3), and (iii) improvements in functional performance, as well as metabolic risk factors...
  23. Albert R La Spada; Fiscal Year: 2016
    ..of a family of proteins known as the "sirtuins", and noted a physical interaction between ataxin-7 and mammalian Sirt1. In this renewal proposal, we outline a series of experiments to define SCA7 epigenetic dysregulation by ..
  24. Chemical Tools to Visualize Sirtuin Activity in Cells
    Anthony A Sauve; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The mammalian sirtuins (SIRT1-7) are NAD+-dependent deacetylase enzymes that regulate adaptations of cells to nutrient availability and are linked to the life-extending and health-providing benefits ..
  25. Anthony A Sauve; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The mammalian sirtuins (SIRT1-7) are NAD+-dependent deacetylase enzymes that deacetylate cellular proteins to regulate their target proteins...
  26. Kevin Pruitt; Fiscal Year: 2015
    ..we propose to do the following: Specific Aim 1 - Determine the role of methyl-CpG binding proteins in targeting SIRT1 to endogenous hypermethylated gene promoters...
  27. Virginia Gao; Fiscal Year: 2015
    ..oxygen species include sirtuins, a class of deacetylases involved in a number of cellular functions, of which SIRT1 is known to play a role in memory...
  28. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..SIRT2 shares large areas of homology with other class I sirtuins, including SIRT1. Although little is known about SIRT2, SIRT1 has been associated with p53 activity and with apoptosis...
  29. ZOLTAN ISTVAN UNGVARI; Fiscal Year: 2014
    ..Importantly, the age-related effects of CR appear to be dependent on the NAD+ dependent protein deacetylase SIRT1. SIRT1 is expressed in the vasculature and regulates multifaceted vasoprotective pathways...
  30. Simon Schenk; Fiscal Year: 2016
    ..The NAD+-dependent protein deacetylase, sirtuin 1 (SIRT1) is activated by CR, and is thought to be the putative signaling node linking age and CR to muscle insulin action...
  31. Mammalian Sir2 Function in Pancreatic Beta Cells
    Shin Ichiro Imai; Fiscal Year: 2012
    ..the physiological significance of a novel metabolic network comprised of systemic NAD biosynthesis as a driver and Sirt1 as a mediator in the regulation of metabolism and aging in mammals...
  32. The AMP-activated protein kinase (AMPK) antagonizes inflammation through SIRT1
    Hang Shi; Fiscal Year: 2012
    ..AMPK functions as a cellular energy gauge that regulates metabolic pathways in lipid and glucose metabolism. SIRT1, which also functions as an energy sensor, is an NAD+dependent deacetylase that mediates the effects of caloric ..
  33. Regulation WRN deacetylation by SIRT1 after DNA damage
    JIANYUAN JACK LUO; Fiscal Year: 2012
    ..elegans. Mammalian Sir2 (SIRT1) has also been found regulating premature cellular senescence induced by the tumor suppressors PML and p53...
  34. Sir2 Regulates AMPK and Lipid Metabolism in Diabetes
    Mengwei Zang; Fiscal Year: 2012
    ..b>SIRT1, a mammalian ortholog of silent information regulator 2 (Sir2), is an NAD-dependent deacetylase mediates the ..
  35. Does SIRT1 regulate mammalian health and longevity?
    Joseph A Baur; Fiscal Year: 2011
    ..It has been proposed that the Sir2/SIRT1 deacetylase is a critical mediator of CR's effects and indeed, Sir2 is necessary for lifespan extension by CR ..
  36. Hypothalamic SIRT1 and Energy Balance
    Eduardo A Nillni; Fiscal Year: 2013
    ..The enzyme Sirt1 is an evolutionarily conserved NAD+-dependent deacetylase involved in many biological processes including cellular ..
  37. Joseph A Baur; Fiscal Year: 2016
    ..We hypothesize that this limits the activity of NAD-dependent enzymes, such as the deacetylase SIRT1, which has strong protective effects against diabetes and other age-related diseases...
  38. Neil B Ruderman; Fiscal Year: 2015
    ..Other studies have suggested a similar role for the sirtuin SIRT1, an NAD-dependent histone/protein deacetylases, best known as a possible mediator of the increased longevity ..
  39. SIRT1 attenuates beta-catenin mediated tumorigenesis
    Eric Bell; Fiscal Year: 2010
    ..Preliminary data indicate that SIRT1, a protein deacetylase that is necessary and sufficient for the anti-aging affects of CR, deacetylates P-catenin ..
  40. Sterling C Johnson; Fiscal Year: 2014
    ..metabolism in the brain assessed in vivo with PET FDG and in situ with assays of key metabolic regulators PGC-1a, SIRT1, mTOR, and AMPK...
  41. JOSEPH ANTHONY GARCIA; Fiscal Year: 2014
    ..recently demonstrated that HIF-2, but not HIF-1, signaling during hypoxia is selectively augmented by Sirtuin 1 (Sirt1), a deacetylase also implicated in aging, nutrient sensing, and genotoxic stress response...
  42. Yong Chao Ma; Fiscal Year: 2014
    ..Specifically, this proposal will focus on SIRT1, a NAD-dependent protein deacetylase that is a master regulator of stress response, and forkhead transcription ..
  43. MARIA JOSE ALMEIDA; Fiscal Year: 2016
    ..The involvement of the histone deacetylase Sirt1 in the inhibition of Wnt/2-catenin by ROS;and co- activation by 2-catenin of the expression of FoxO-target genes ..
  44. MELANIE MARIA OTT; Fiscal Year: 2014
    ..We find that Tat hyperactivates T cells by blocking the deacetylase activity of SIRT1 (Kwon et al, Cell Host Microbe, 2008)...
  45. Androgen Receptor Function in Prostate Cancer
    Richard G Pestell; Fiscal Year: 2013
    ..We showed that 1. AR acetylation and phosphorylation are linked, 2. SirT1 expression and function are regulated by dihydrotestosterone (DHT) and metabolism 3...
  46. Generating Blood-based Diagnosis for Alzheimer Disease
    Eugenia Wang; Fiscal Year: 2012
    ..In this proposal, we focus on a specific up-regulated microRNA, miR-34a, whose known targets are SIRT1, cdk4, cdk6, cyclin E2, bcl2, etc. SIRT1 is a member of the 7-member Silent Information Regulator protein family...
  47. Rozalyn M Anderson; Fiscal Year: 2014
    ..We have proposed that CR-induced alterations in GSK32 and SIRT1 act through PGC-11 to implement the metabolic reprogramming observed in WAT from CR mice...
  48. Effect of nutritional status on MRP2 expression and biliary excretion of bispheno
    Angela L Slitt; Fiscal Year: 2012
    ..RES) is an antioxidant in red wine with anti-aging effects that mimic CR, and is an agonist for the deacetylase Sirt1. Understanding how RES, fasting, and CR regulate the expression and function of liver transporters involved in ..
  49. SIRT1, AMPK , and hepatocyte nutrient sensing
    LAUREN NELSON DISE; Fiscal Year: 2012
    ..Two proteins that stand out as candidates for the study of this process are SIRT1 and AMPK...
  50. Molecular Mechanisms of Age-related Impairment of Muscle Regeneration
    Thomas A Rando; Fiscal Year: 2013
    ..3) To explore the molecular interactions between the Wnt signaling pathway with two key "longevity genes", SIRT1 and Klotho, and the functional significance of these interactions in terms of stem cell functionality in adult and ..
  51. Hal E Broxmeyer; Fiscal Year: 2016
    ..b>Sirt1, a member of the Sirtuin family of deacetylases, has been linked to longevity and stress tolerance in budding ..
  52. Role of Chromatin in Genomic Maintenance
    David A Sinclair; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The SIR2/SIRT1 gene is an ancient gene that delays aging in diverse organisms, from yeast to flies, and potentially even mammals...
  53. Marc R Montminy; Fiscal Year: 2016
    ..TORC2 is silenced through SIRT1-mediated deacetylation during prolonged fasting, when FOXO1 is reciprocally activated...
  54. Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 Pathway
    Marc R Montminy; Fiscal Year: 2010
    ..TORC2 is silenced through SIRT1-mediated deacetylation during prolonged fasting, when FOXO1 is reciprocally activated...
  55. Kenneth S Shindler; Fiscal Year: 2016
    ..b>SIRT1 is an NAD+-dependent deacetylase involved in cellular stress responses and cell survival that may reduce oxidative ..
  56. Ulf Beier; Fiscal Year: 2015
    ..We propose to study the role of Sirtuin-1 (Sirt1), a class III HDAC highly conserved across eukaryotic species and an important mediator of cellular metabolism and ..
  57. Development of cambinol analogues as antilymphoma agents
    Antonio Bedalov; Fiscal Year: 2012
    ..to synthesize and evaluate analogues of cambinol, a small molecule inhibitor of human NAD-dependent deacetylases SIRT1 and SIRT2, and to validate SIRT1 and/or SIRT2 as therapeutic targets in germinal center lymphomas...
  58. HTS of Compounds Modulating PGC-1a Acetylation and Oxidative Metabolic Function
    Pere Puigserver; Fiscal Year: 2012
    ..Deacetylation of PGC-11 through Sirt1 is one of the key chemical modifications that activate PGC-11 under exercise or nutrient deprivation conditions...
  59. EPIGENETIC AGING OF THE OXIDATIVE STRESS RESPONSE IN THE MOUSE RPE
    Zeljka Smit McBride; Fiscal Year: 2010
    ..The set includes Er1, Err1, Foxo3a, Nrf2, Pgc11, Prdx3, p66/Shc1, Sirt1, Sod2, Txn2, Txnrd2, and 14-3-38...
  60. Wenyong Chen; Fiscal Year: 2015
    ..The long term goal is to understand how a stress-response gene SIRT1 is involved in regulating mammalian longevity and cancer, and to develop novel strategies for cancer treatment and ..
  61. Barry London; Fiscal Year: 2016
    ..b>SIRT1 is a mammalian protein lysine deacetylase which belongs to the SIRTUIN family of NAD+-dependent deacetylases...
  62. Molecular mechanisms of fatty liver disease: role of the protein DBC1
    Eduardo N Chini; Fiscal Year: 2013
    ..and biochemical roles of DBC1, however recent studies indicate that DBC1 binds and inhibits the enzyme SIRT1. SIRT1 is a NAD-dependent deacetylase that controls metabolism, ageing and longevity...
  63. Pier Paolo Pandolfi; Fiscal Year: 2014
    ..We have identified specific phosphorylation and acetylation sites in LRF and we have demonstrated that GSK32 and SIRT1 are responsible for these modifications...