SOX2

Summary

Gene Symbol: SOX2
Description: SRY-box 2
Alias: ANOP3, MCOPS3, transcription factor SOX-2, SRY (sex determining region Y)-box 2, SRY-related HMG-box gene 2, sex determining region Y-box 2, transcription factor SOX2
Species: human

Top Publications

  1. pmc Core transcriptional regulatory circuitry in human embryonic stem cells
    Laurie A Boyer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 122:947-56. 2005
  2. pmc EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells
    Nicolò Riggi
    Division of Experimental Pathology, Institute of Pathology, University of Lausanne, Lausanne CH 1011, Switzerland
    Genes Dev 24:916-32. 2010
  3. doi Sox2 expression in breast tumours and activation in breast cancer stem cells
    O Leis
    Regulation of Cell Growth Laboratory, Fundación Inbiomed, San Sebastian, Spain
    Oncogene 31:1354-65. 2012
  4. doi SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network
    Xuefei Li
    School of Medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China
    Cancer Lett 336:379-89. 2013
  5. doi SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity
    Munehide Nakatsugawa
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Lab Invest 91:1796-804. 2011
  6. doi The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer
    Yupeng Chen
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
    J Biol Chem 283:17969-78. 2008
  7. pmc SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas
    Thomas Hussenet
    Département Biologie du Cancer, Institut National de la Sante et de la Recherche Medicale, Institut de Genetique et de Biologie Moleculaire et Cellulaire, U964 Illkirch, France
    PLoS ONE 5:e8960. 2010
  8. doi SOX2 expression associates with stem cell state in human ovarian carcinoma
    Petra M Bareiss
    Departments of Internal Medicine II and Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, University of Tuebingen, Tuebingen, Germany
    Cancer Res 73:5544-55. 2013
  9. pmc Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma
    Lynette M Sholl
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 34:1193-8. 2010
  10. pmc Silencing SOX2 induced mesenchymal-epithelial transition and its expression predicts liver and lymph node metastasis of CRC patients
    Xu Han
    Systems Biology Division, Zhejiang California International Nanosystems Institute, Zhejiang University, Hangzhou, Zhejiang, China
    PLoS ONE 7:e41335. 2012

Research Grants

  1. TSHR and thyrocyte development
    Reigh Yi Lin; Fiscal Year: 2013
  2. Differentiating Nkx2.1-positive lung epithelial progenitors from ES cells
    Jayaraj Rajagopal; Fiscal Year: 2013
  3. Herman S Cheung; Fiscal Year: 2014
  4. Generation of Human iPS Cells via Non-integrating Vectors
    Wen Shu Wu; Fiscal Year: 2010
  5. Function of KLF4-expressing stem cells in mouse cutaneous wound healing
    Walden Ai; Fiscal Year: 2013
  6. Cardiovascular and Therapeutic Potential of Reprogrammed Human Fibroblasts
    WILLIAM ROBB MACLELLAN; Fiscal Year: 2010
  7. Aging and Reprogramming of Somatic Cells to Pluripotency
    Peter J Hornsby; Fiscal Year: 2010
  8. JAMES ALEXANDER THOMSON; Fiscal Year: 2015
  9. miRNAs regulate lung epithelial progenitor cells in development and injury repair
    Ying Tian; Fiscal Year: 2013
  10. Mana M Parast; Fiscal Year: 2014

Detail Information

Publications258 found, 100 shown here

  1. pmc Core transcriptional regulatory circuitry in human embryonic stem cells
    Laurie A Boyer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 122:947-56. 2005
    The transcription factors OCT4, SOX2, and NANOG have essential roles in early development and are required for the propagation of undifferentiated embryonic stem (ES) cells in culture...
  2. pmc EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells
    Nicolò Riggi
    Division of Experimental Pathology, Institute of Pathology, University of Lausanne, Lausanne CH 1011, Switzerland
    Genes Dev 24:916-32. 2010
    ..ESFTs and believed to initiate their pathogenesis, induces expression of the embryonic stem cell (ESC) genes OCT4, SOX2, and NANOG in human pediatric MSCs (hpMSCs) but not in their adult counterparts...
  3. doi Sox2 expression in breast tumours and activation in breast cancer stem cells
    O Leis
    Regulation of Cell Growth Laboratory, Fundación Inbiomed, San Sebastian, Spain
    Oncogene 31:1354-65. 2012
    ..Expression of pluripotency genes (Oct4, Nanog and Sox2) was tested in breast tumours by immunohistochemistry and it was found that Sox2 is expressed in early stage breast ..
  4. doi SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network
    Xuefei Li
    School of Medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China
    Cancer Lett 336:379-89. 2013
    b>SOX2 was reported to promote metastasis in various tumor tissues; however the underlying mechanisms remain elusive...
  5. doi SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity
    Munehide Nakatsugawa
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Lab Invest 91:1796-804. 2011
    Recently, the SOX2 gene has been reported to be amplified in human lung squamous cell carcinomas. However, its roles in human lung adenocarcinomas are still elusive...
  6. doi The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer
    Yupeng Chen
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
    J Biol Chem 283:17969-78. 2008
    ..Using cell culture experiments, tissue analysis, molecular profiling, and animal studies, we report here that SOX2 promotes cell proliferation and tumorigenesis by facilitating the G(1)/S transition and through its transcription ..
  7. pmc SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas
    Thomas Hussenet
    Département Biologie du Cancer, Institut National de la Sante et de la Recherche Medicale, Institut de Genetique et de Biologie Moleculaire et Cellulaire, U964 Illkirch, France
    PLoS ONE 5:e8960. 2010
    ..occur in 20% of lung SCC (136 tumors in total) and map to a core region of 2 Mb (Megabases) that encompasses SOX2, a transcription factor gene...
  8. doi SOX2 expression associates with stem cell state in human ovarian carcinoma
    Petra M Bareiss
    Departments of Internal Medicine II and Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, University of Tuebingen, Tuebingen, Germany
    Cancer Res 73:5544-55. 2013
    The SRY-related HMG-box family of transcription factors member SOX2 regulates stemness and pluripotency in embryonic stem cells and plays important roles during early embryogenesis...
  9. pmc Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma
    Lynette M Sholl
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 34:1193-8. 2010
    Many patients with stage I nonsmall cell lung carcinoma will develop recurrence after surgical excision. Sox2 is a marker of embryonic stem cell pluripotency that is associated with aggressive tumor behavior and is expressed in a subset ..
  10. pmc Silencing SOX2 induced mesenchymal-epithelial transition and its expression predicts liver and lymph node metastasis of CRC patients
    Xu Han
    Systems Biology Division, Zhejiang California International Nanosystems Institute, Zhejiang University, Hangzhou, Zhejiang, China
    PLoS ONE 7:e41335. 2012
    b>SOX2 is an important stem cell marker and plays important roles in development and carcinogenesis. However, the role of SOX2 in Epithelial-Mesenchymal Transition has not been investigated...
  11. doi Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma
    Kolja Freier
    Abteilung Molekulare Genetik B060, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg D 69120, Germany
    Genes Chromosomes Cancer 49:9-16. 2010
    ..analyses by quantitative real time polymerase chain reaction found high mRNA expression of candidate genes SOX2 in 3q26.33, FSLT3 in 19p13.3, and CCNE1 in 19q12...
  12. ncbi Oct3/4 and Sox2 are significantly associated with an unfavorable clinical outcome in human esophageal squamous cell carcinoma
    Qi Wang
    Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway
    Anticancer Res 29:1233-41. 2009
    The embryonic stem cell factors Oct3/4 and Sox2 are essential for pluripotency and self-renewal of embryonic stem cells...
  13. doi Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells
    Maria Ferletta
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    Int J Cancer 129:45-60. 2011
    Numerous studies support a role for Sox2 to keep stem cells and progenitor cells in an immature and proliferative state...
  14. doi MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
    Na Xu
    Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, The University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Cell 137:647-58. 2009
    ..We identify the pluripotency factors OCT4, SOX2, and KLF4 as direct targets of miR-145 and show that endogenous miR-145 represses the 3' untranslated regions of ..
  15. doi Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Ann Surg Oncol 16:3488-98. 2009
    ..We investigated the role of three stem cell markers (CD133, OCT4, and SOX2) in rectal cancer and evaluated the association between these gene levels and clinical outcome in rectal cancer ..
  16. doi Expression pattern of Oct-4, Sox2, and c-Myc in the primary culture of human dental pulp derived cells
    Lu Liu
    Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Sun Yat Sen University, Guangzhou, Guangdong, China
    J Endod 37:466-72. 2011
    ..Recently, the transcription factors of Oct-4, Sox2, c-Myc, and Klf4 have been reported to play a regulatory role in the stem cell self-renewal process, namely cell ..
  17. pmc Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile
    Daniel Hägerstrand
    Department of Oncology Pathology, Karolinska Institutet, Cancer Center Karolinska, Karolinska University Hospital in Solna, SE 171 76, Stockholm, Sweden
    Neuro Oncol 13:1178-91. 2011
    ..The type A cultures displayed high expression of CXCR4, SOX2, EAAT1, and GFAP and low expression of CNP, PDGFRB, CXCL12, and extracellular matrix proteins...
  18. pmc SOX2 targets fibronectin 1 to promote cell migration and invasion in ovarian cancer: new molecular leads for therapeutic intervention
    Xiaoyan Lou
    1 Systems Biology Division and Propriumbio Research Center, Zhejiang California International Nanosystems Institute ZCNI, Zhejiang University, Hangzhou, China
    OMICS 17:510-8. 2013
    ..To this end, the human transcription factor SOX2 is involved in a wide range of pathophysiological roles, such as the maintenance of stem cell ..
  19. doi Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells
    Zheng Wang
    Yale Stem Cell Center, Department of Genetics, Yale University, New Haven, CT 06520, USA
    Cell Stem Cell 10:440-54. 2012
    Nanog, Oct4, and Sox2 are the core regulators of mouse (m)ESC pluripotency. Although their basic importance in human (h)ESCs has been demonstrated, the mechanistic functions are not well defined...
  20. doi Expression of Sox2 in human cervical carcinogenesis
    Jing Ji
    Department of Reproductive Medicine, The First Affiliated Hospital of Medical School, Xi an Jiaotong University, Xi an, The People s Republic of China
    Hum Pathol 41:1438-47. 2010
    b>Sox2 is a key transcription factor for embryonic development and plays a critical role in determining the fate of stem cells. Recently, Sox2 has been detected in several human tumors, indicating a potential function in tumorigenesis...
  21. doi Role of Sox2 and Oct4 in predicting survival of hepatocellular carcinoma patients after hepatectomy
    Pinzhu Huang
    Department of Hepatobiliary Oncology, Sun Yat sen University Cancer Center, Guangzhou, GD 510060, China
    Clin Biochem 44:582-9. 2011
    The present study was aimed to explore the prognostic strength of Sox2 and Oct4A in hepatocellular carcinoma (HCC).
  22. doi Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis
    A J M Gillis
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Josephine Nefkens Institute, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Int J Androl 34:e160-74. 2011
    OCT3/4, NANOG, SOX2 and, most recently, LIN28 have been identified as key regulators of pluripotency in mammalian embryonic and induced stem cells, and are proven to be crucial for generation of the mouse germ-cell lineage...
  23. ncbi Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer
    D C Ambrosetti
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 275:23387-97. 2000
    ..inner cell mass of the blastocyst and in EC cells requires the combined activity of two transcriptional regulators, Sox2 and Oct-3, which bind to adjacent sites on the FGF-4 enhancer DNA and synergistically activate transcription...
  24. doi Sox2 expression in pulmonary non-small cell and neuroendocrine carcinomas
    Lynette M Sholl
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Appl Immunohistochem Mol Morphol 18:55-61. 2010
    b>Sox2 is a transcription factor that regulates embryonic stem cell pluripotency and drives commitment of airway precursor cells to basal-type and neuroendocrine cells in the developing lung...
  25. ncbi Reprogramming of human somatic cells to pluripotency with defined factors
    In Hyun Park
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 451:141-6. 2008
    ..have been reprogrammed directly to pluripotency by ectopic expression of four transcription factors (Oct4, Sox2, Klf4 and Myc) to yield induced pluripotent stem (iPS) cells...
  26. doi ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers
    Xuefeng Fang
    Cancer Institute Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People s Republic of China
    OMICS 14:369-84. 2010
    b>SOX2 is an HMG box containing transcription factor that has been implicated in various types of cancer, but its role in colorectal cancers (CRC) has not been studied...
  27. pmc Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma
    Claudia Lengerke
    University of Tuebingen Medical Center II, Otfried Mueller Strasse 10, 72076 Tuebingen, Germany
    BMC Cancer 11:42. 2011
    The SRY-related HMG-box family of transcription factors member SOX2 has been mainly studied in embryonic stem cells as well as early foregut and neural development...
  28. doi Sox2 targets cyclinE, p27 and survivin to regulate androgen-independent human prostate cancer cell proliferation and apoptosis
    F Lin
    Department of Biochemistry and Molecular Biology, College of Basic Medical Science, Harbin Medical University, Harbin, China
    Cell Prolif 45:207-16. 2012
    b>Sox2 is a major transcription factor and the transforming growth factor-α (TGF-α)/EGFR autocrine loop is a hallmark of prostate cancer progression...
  29. doi MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2
    Juan Li
    Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, Shandong Province, China
    Cancer Lett 329:84-90. 2013
    ..Functionally, miR-429 overexpression suppressed cell apoptosis by directly targeting SOX2 in HT-29 cells...
  30. pmc SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis
    T Otsubo
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45, Yushima, Tokyo 113 8519, Japan
    Br J Cancer 98:824-31. 2008
    ..We previously reported that the SOX2 protein is expressed in normal gastric mucosae but downregulated in some human gastric carcinomas...
  31. ncbi Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene
    Shin ichi Aota
    Department of Molecular Biology, Biomolecular Engineering Research Institute BERI, 6 2 3 Furuedai, 565 0874, Suita, Osaka, Japan
    Dev Biol 257:1-13. 2003
    ..sequence contains three plausible sites of HMG domain recognition, and HMG domain-containing transcription factors Sox2 and Sox3 activated LE9 synergistically with Pax6...
  32. pmc Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis
    Flavio Cimadamore
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 8:538-51. 2011
    The transcription factor SOX2 is widely known to play a critical role in the central nervous system; however, its role in peripheral neurogenesis remains poorly understood...
  33. pmc Cord blood stem cells revert glioma stem cell EMT by down regulating transcriptional activation of Sox2 and Twist1
    Kiran Kumar Velpula
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA
    Oncotarget 2:1028-42. 2011
    ..In this regard, our studies on hGBM tissue grade IV specimens showed significant expression of Twist1 and Sox2, known mesenchymal and stemness related markers, respectively, indicating their association with glial tumor ..
  34. pmc EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer
    Sandeep Singh
    Department of Tumor Biology, H, Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA
    Mol Cancer 11:73. 2012
    ..Further, we investigated if the self-renewal of SP cells is dependent on EGFR mediated signaling...
  35. doi Acetylation of sox2 induces its nuclear export in embryonic stem cells
    Gretchen A Baltus
    Developmental and Molecular Pathways, Novartis Institute of Biomedical Research, Cambridge, Massachusetts 02139, USA
    Stem Cells 27:2175-84. 2009
    ..Central to these processes are the proteins Oct4, Nanog, and Sox2. Although the transcriptional targets of these factors have been extensively studied, very little is known about ..
  36. ncbi Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions
    Eun Taek Park
    Gastrointestinal Research Laboratory, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Int J Cancer 122:1253-60. 2008
    ..b>SOX2, an HMG-box transcription factor expressed in gastric mucosa but not in intestine is thought to play an important ..
  37. doi Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells
    Helen Fong
    Sue and Bill Gross Stem Cell Research Program, Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA
    Stem Cells 26:1931-8. 2008
    ..Studies in mice have implicated three factors in regulating pluripotency in embryonic stem cells, Oct4, Nanog, and Sox2. However, significant differences in growth regulation between mouse embryonic stem and hES cells have been ..
  38. pmc Novel SOX2 mutations and genotype-phenotype correlation in anophthalmia and microphthalmia
    Adele Schneider
    Albert Einstein Medical Center, Department of Pediatrics Division of Genetics, Milwaukee, Wisconsin, USA
    Am J Med Genet A 149:2706-15. 2009
    b>SOX2 represents a High Mobility Group domain containing transcription factor that is essential for normal development in vertebrates...
  39. pmc Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma
    Nan Ge
    State Key Laboratory of Oncology in South China, Cancer Center of Sun Yat Sen University, Guangzhou 510060, China
    J Transl Med 8:94. 2010
    Oct4 and Sox2 are two major transcription factors related to the stem cell self-renewal and differentiation...
  40. ncbi Expression of Sox2 in mature and immature teratomas of central nervous system
    Ji Hoon Phi
    Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea
    Mod Pathol 20:742-8. 2007
    b>Sox2 is a transcription factor that plays a critical role in the maintenance of the self-renewal capability of neural stem cells...
  41. doi SOX2 gene amplification and protein overexpression are associated with better outcome in squamous cell lung cancer
    Theresia Wilbertz
    Institute of Pathology, Comprehensive Cancer Center, University Hospital Tuebingen, Tuebingen, Germany
    Mod Pathol 24:944-53. 2011
    The transcription factor SOX2 (3q26.3-q27) is a key regulator of foregut development and an embryonic stem cell factor cooperating during induction of pluripotency in terminally differentiated somatic cells...
  42. pmc Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers
    Attila Remenyi
    Gene Expression Program, EMBL, 69117 Heidelberg, Germany
    Genes Dev 17:2048-59. 2003
    ..In this study, we focus on two transcription factors, Oct4 and Sox2, as their combination on DNA is considered to direct the establishment of the first three lineages in the mammalian ..
  43. pmc Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology
    Alvaro C Laga
    Department of Pathology, Program in Dermatopathology, Boston, MA 02115, USA
    Am J Pathol 176:903-13. 2010
    b>SOX2 is a gene located on chromosome 3q26.33 that encodes a transcription factor important to maintenance of embryonic neural crest stem cell pluripotency...
  44. doi Sox2 nuclear expression is closely associated with poor prognosis in patients with histologically node-negative oral tongue squamous cell carcinoma
    Lutao Du
    Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, PR China
    Oral Oncol 47:709-13. 2011
    b>Sox2 is a marker of embryonic stem cell pluripotency and plays an important role in tumor progression...
  45. doi Diagnostic utility of neural stem and progenitor cell markers nestin and SOX2 in distinguishing nodal melanocytic nevi from metastatic melanomas
    Pei Ling Chen
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Mod Pathol 26:44-53. 2013
    ..Recent studies have demonstrated strong expression of neural stem/progenitor cell markers nestin and SOX2 in melanoma...
  46. pmc Influence of adriamycin on changes in Nanog, Oct-4, Sox2, ARID1 and Wnt5b expression in liver cancer stem cells
    Ding Sun
    Ding Sun, Lei Qin, Yang Xu, Jian Xia Liu, Li Ping Tian, Hai Xin Qian, Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
    World J Gastroenterol 20:6974-80. 2014
    To determine the influence of Adriamycin (ADM) on the changes in Nanog, Oct4, Sox2, as well as, in ARID1 and Wnt5b expression in liver cancer stem cells.
  47. ncbi Sox2 expression in brain tumors: a reflection of the neuroglial differentiation pathway
    Ji Hoon Phi
    Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea
    Am J Surg Pathol 32:103-12. 2008
    b>Sox2 is a key transcription factor that maintains the proliferation of neuroglial stem cells and inhibits neuronal fate commitment...
  48. pmc CARM1 mediates modulation of Sox2
    Hai Yong Zhao
    National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 6:e27026. 2011
    b>Sox2 is a key component of the transcription factor network that maintains the pluripotent state of embryonic stem cells (ESCs)...
  49. pmc Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus
    Dongying Zhang
    Rolf Luft Center for Diabetes Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
    BMC Med Genet 11:116. 2010
    MCF2L2, ADIPOQ and SOX2 genes are located in chromosome 3q26-27, which is linked to diabetic nephropathy (DN). ADIPOQ and SOX2 genetic polymorphisms are found to be associated with DN...
  50. doi Hypoxia induces CD133 expression in human lung cancer cells by up-regulation of OCT3/4 and SOX2
    Hajime Iida
    Department of Biochemistry, University of Occupational and Environmental Health, Fukuoka, Japan
    Int J Oncol 40:71-9. 2012
    ..direct binding of Octamer biding trans-cription factor 3/4 (OCT4) and/or SRY-box containing gene 2 (SOX2) to the P1 promoter region of CD133 gene loci...
  51. pmc High SOX2 levels predict better outcome in non-small cell lung carcinomas
    Vamsidhar Velcheti
    Department of Medical Oncology, Yale University School of Medicine, New Haven, Connecticut, USA
    PLoS ONE 8:e61427. 2013
    b>SOX2 is an embryonic developmental transcription factor, which is important in the development of the respiratory tract. SOX2 overexpression is associated with aggressive disease in several tumor types...
  52. doi SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell
    Xianpei Jia
    Medical School of Nankai University, Tianjin, China
    J Mol Cell Biol 3:230-8. 2011
    SRY-related HMG-box gene 2 (SOX2) is one of the key regulatory genes that maintain the pluripotency and self-renewal properties in embryonic stem cells...
  53. pmc Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells
    Jochen Utikal
    Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Massachusetts General Hospital Center for Regenerative Medicine, 185 Cambridge Street, Boston, MA 02114, USA
    J Cell Sci 122:3502-10. 2009
    ..at low frequencies from different cell types through ectopic expression of the transcription factors Oct4 and Sox2, combined with either Klf4 and c-Myc or Lin28 and Nanog...
  54. doi Pluripotency regulators in human mesenchymal stem cells: expression of NANOG but not of OCT-4 and SOX-2
    Enrico Pierantozzi
    Molecular Medicine Section, Department of Neuroscience, University of Siena, Siena, Italy
    Stem Cells Dev 20:915-23. 2011
    ..factors that regulate the maintenance of the pluripotent state in embryonic stem cells, including NANOG, SOX2, and OCT4, have been proposed to play a similar role also in adult stem cells, although with conflicting results...
  55. doi Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays
    Harini Chakravarthy
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Cell Physiol 216:651-62. 2008
    b>Sox2 and Oct-3/4 function as master regulators during mammalian embryogenesis, where they are believed to regulate a critical gene regulatory network by cooperatively binding to DNA regulatory regions composed of adjacent HMG and POU ..
  56. pmc Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer
    A O Gure
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:4198-203. 2000
    ..lines using pooled sera of SCLC patients led to the isolation of 14 genes, including 4 SOX group B genes (SOX1, SOX2, SOX3, and SOX21) and ZIC2...
  57. pmc Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development
    Y Kamachi
    Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Dev 15:1272-86. 2001
    ..We demonstrate that Pax6 initiates lens development by forming a molecular complex with SOX2 on the lens-specific enhancer elements, e.g., the delta-crystallin minimal enhancer DC5...
  58. ncbi Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor SOX2: comparison of expression patterns between invasive components and cancerous or nonneoplastic intr
    Yuichi Sanada
    Department of Surgical Oncology, Research Institution for Radiation Biology and Medicine, Hiroshima University, 1 2 3 Kasumi, Hiroshima 734 8551, Japan
    Pancreas 32:164-70. 2006
    The purpose of this study was to perform histopathologic and immunohistochemical analyses of gastric transcription factor SOX2 and gastric mucin MUC5AC to better understand the stepwise progression of pancreatic carcinoma.
  59. ncbi Germinal mosaicism and familial recurrence of a SOX2 mutation with highly variable phenotypic expression extending from AEG syndrome to absence of ocular involvement
    Nicolas Chassaing
    Department of Medical Genetics, Hopital Purpan, Toulouse, France
    Am J Med Genet A 143:289-91. 2007
  60. pmc Sox2 uses multiple domains to associate with proteins present in Sox2-protein complexes
    Jesse L Cox
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 5:e15486. 2010
    Master regulators, such as Sox2, Oct4 and Nanog, control complex gene networks necessary for the self-renewal and pluripotency of embryonic stem cells (ESC)...
  61. pmc Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans
    Daniel Kelberman
    London Centre for Paediatric Endocrinology, Biochemistry, Endocrinology, Institute of Child Health, University College London, London, United Kingdom
    J Clin Invest 116:2442-55. 2006
    The transcription factor SOX2 is expressed most notably in the developing CNS and placodes, where it plays critical roles in embryogenesis...
  62. ncbi Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families
    Goslik E Schepers
    Dev Cell 3:167-70. 2002
  63. pmc Anophthalmia and microphthalmia
    Amit S Verma
    MRC Human Genetics Unit, Edinburgh, UK
    Orphanet J Rare Dis 2:47. 2007
    ..Chromosomal duplications, deletions and translocations are implicated. Of monogenic causes only SOX2 has been identified as a major causative gene. Other linked genes include PAX6, OTX2, CHX10 and RAX...
  64. ncbi Pairing SOX off: with partners in the regulation of embryonic development
    Y Kamachi
    Institute for Molecular and Cellular Biology, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Trends Genet 16:182-7. 2000
    ..The focus of this article is the mechanism of action of SOX proteins, in particular, how SOX proteins specifically pair off with respective partner factors and, as a consequence, select distinct sets of genes as their regulatory targets...
  65. ncbi Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia
    Tetsuya Tsukamoto
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Nagoya, Chikusa ku, Japan
    J Cancer Res Clin Oncol 130:135-45. 2004
    ..Hence, we here analyzed Sox2, a human homolog of a chicken gastric transcription factor, with reference to our new classification for gastric/..
  66. ncbi Mutations in SOX2 cause anophthalmia-esophageal-genital (AEG) syndrome
    Kathleen A Williamson
    Medical Genetics Section, MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Hum Mol Genet 15:1413-22. 2006
    We report heterozygous, loss-of-function SOX2 mutations in three unrelated individuals with Anophthalmia-Esophageal-Genital (AEG) syndrome. One previously reported case [Rogers, R.C. (1988) Unknown cases...
  67. pmc SOX2 anophthalmia syndrome: 12 new cases demonstrating broader phenotype and high frequency of large gene deletions
    P Bakrania
    Dept of Physiology, Anatomy and Genetics, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX, United Kingdom
    Br J Ophthalmol 91:1471-6. 2007
    ..Heterozygous mutations in SOX2, a SOX1B-HMG box transcription factor, have been found in up to 10% of individuals with severe microphthalmia or ..
  68. doi The early human germ cell lineage does not express SOX2 during in vivo development or upon in vitro culture
    Rebecca M Perrett
    Centre for Human Development, Stem Cells and Regeneration, Human Genetics Division, University of Southampton, Southampton SO16 6YD, United Kingdom
    Biol Reprod 78:852-8. 2008
    NANOG, POU5F1, and SOX2 are required by the inner cell mass of the blastocyst and act cooperatively to maintain pluripotency in both mouse and human embryonic stem cells...
  69. doi Hypermethylation of SOX2 gene in hydatidiform mole and choriocarcinoma
    Albert S M Li
    Department of Pathology, Queen Mary Hospital, Hong Kong, China
    Reprod Sci 15:735-44. 2008
    This study investigated the expression and methylation profiles of SOX2, a stem cell-related transcription factor, in placentas and gestational trophoblastic disease...
  70. doi SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity
    Rosaria Maria Rita Gangemi
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Stem Cells 27:40-8. 2009
    ..Glioblastoma cells express several genes typical of normal neural stem cells. One of them, SOX2, is a master gene involved in sustaining self-renewal of several stem cells, in particular neural stem cells...
  71. ncbi Genes involved in regulation of stem cell properties: studies on their expression in a small cohort of neuroblastoma patients
    Mariarosa A B Melone
    Department of Pediatrics F Fede, Second University of Naples, Naples 80138, Italy
    Cancer Biol Ther 8:1300-6. 2009
    ..In several specimens we detected the expression of genes belonging to the OCT3/SOX2/NANOG/KLF4 core circuitry that acts at the highest level in regulating stem cell biology...
  72. pmc Novel SOX2 partner-factor domain mutation in a four-generation family
    Marija Mihelec
    The Children s Hospital at Westmead, Children s Medical Research Institute and Save Sight Institute, Sydney, NSW, Australia
    Eur J Hum Genet 17:1417-22. 2009
    ..In most cases the underlying genetic cause is unknown, but mutations in some genes, such as SOX2, cause ocular developmental defects, particularly anophthalmia, in a subset of patients...
  73. doi Helicobacter pylori induces gastric mucosal intestinal metaplasia through the inhibition of interleukin-4-mediated HMG box protein Sox2 expression
    Sho Asonuma
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Am J Physiol Gastrointest Liver Physiol 297:G312-22. 2009
    ..A SRY-related HMG box protein Sox2 is an essential transcription factor of organ development in brain, lung, and stomach...
  74. doi SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract
    Kevin B Long
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 40:1768-73. 2009
    b>SOX2 is a high-mobility group box embryonic stem cell transcription factor that is expressed in the developing foregut and normal gastric epithelium and is downregulated in intestinal metaplasia of the stomach and esophagus...
  75. doi SOX2 has gender-specific genetic effects on diabetic nephropathy in samples from patients with type 1 diabetes mellitus in the GoKinD study
    Harvest F Gu
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Gend Med 6:555-64. 2009
    Sex-determining region Y-box 2 (SOX2) is a transcription factor that plays an important role in the induction of pluripotent stem cells from somatic cells. The SOX2 gene is located in chromosome 3q26...
  76. doi Role of SOX2 in maintaining pluripotency of human embryonic stem cells
    Keiko Adachi
    Department of Development and Differentiation, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara cho, Shougoin, Sakyo ku, Kyoto 606 8507, Japan
    Genes Cells 15:455-70. 2010
    ..cell (ESC) pluripotency is thought to be regulated by several key transcription factors including OCT4, NANOG, and SOX2. Although the functions of OCT4 and NANOG in human ESCs are well defined, that of SOX2 has not been fully ..
  77. doi SOX2 gene expression in normal human thymus and thymoma
    Anca Maria Cimpean
    Department of Histology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
    Clin Exp Med 11:251-4. 2011
    ..like small cell lung carcinoma, meningioma, gastric, and pancreatic cancer, have been found to be immunogenic for SOX2 protein...
  78. doi Role of the stemness factors sox2, oct3/4, and nanog in gastric carcinoma
    Junko Matsuoka
    Department of Surgical Oncology, Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Surg Res 174:130-5. 2012
    ..Recently, the stemness factors Sox2, Oct3/4, and Nanog were associated with induced pluripotent stem cells, suggesting a correlation between these ..
  79. pmc Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas
    U Basu-Roy
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Oncogene 31:2270-82. 2012
    ..In this report we show that the stem cell transcription factor Sox2 is highly expressed in human and murine osteosarcoma (mOS) cell lines as well as in the tumor samples...
  80. pmc Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas
    Marta M Alonso
    Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e26740. 2011
    We undertook this study to understand how the transcription factor Sox2 contributes to the malignant phenotype of glioblastoma multiforme (GBM), the most aggressive primary brain tumor...
  81. pmc SOX2-RNAi attenuates S-phase entry and induces RhoA-dependent switch to protease-independent amoeboid migration in human glioma cells
    Felix Oppel
    Department of Neurosurgery, Section Experimental Neurosurgery and Tumor Immunology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Mol Cancer 10:137. 2011
    b>SOX2, a high mobility group (HMG)-box containing transcription factor, is a key regulator during development of the nervous system and a persistent marker of neural stem cells. Recent studies suggested a role of SOX2 in tumor progression...
  82. pmc Sex-determining region Y-box 2 expression predicts poor prognosis in human ovarian carcinoma
    Jing Zhang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 43:1405-12. 2012
    ..035; log-rank test). Our results showed that sex-determining region Y-box 2 expression may be a potential marker related to tumor recurrence, as implicated by its role in cancer stem cells...
  83. doi Morphologic and clinicopathologic features of lung squamous cell carcinomas expressing Sox2
    Luka Brcic
    Dept of Pathology PUH C608, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Am J Clin Pathol 138:712-8. 2012
    b>Sox2 amplification was recently reported as a common event in squamous cell carcinomas (SCCs) occurring at different anatomic sites including the lung...
  84. doi SOX2 overexpression correlates with poor prognosis in laryngeal squamous cell carcinoma
    Xia Bing Tang
    Department of Otolaryngology, Head and Neck Surgery, Wuxi People s Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, PR China
    Auris Nasus Larynx 40:481-6. 2013
    The aim of present study was to investigate the expression of SOX2, a key transcription factor, in LSCC and to assess its prognostic significance.
  85. pmc SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors
    Flavio Cimadamore
    Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:E3017-26. 2013
    The transcription factor SRY (sex-determining region)-box 2 (SOX2) is an important functional marker of neural precursor cells (NPCs) and plays a critical role in self-renewal and neuronal differentiation; however, the molecular ..
  86. doi The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis
    Shi Yan Ng
    Stem Cell and Developmental Biology Group, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore
    Mol Cell 51:349-59. 2013
    ..RMST physically interacts with SOX2, a transcription factor known to regulate neural fate...
  87. pmc Elevated expression of SOX2 and FGFR1 in correlation with poor prognosis in patients with small cell lung cancer
    Fang Yang
    Department of Respiratory Medical Oncology, The Tumor Hospital Affiliated Harbin Medical University Harbin, China
    Int J Clin Exp Pathol 6:2846-54. 2013
    The central issue in this study is to investigate the expression of Sex determining region Y-BOX2 (SOX2) and fibroblast growth factor receptor 1 (FGFR1), evaluate their clinicopathological variables and prognostic significance in small ..
  88. ncbi Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3
    H Yuan
    Department of Microbiology, New York University School of Medicine, New York 10016, USA
    Genes Dev 9:2635-45. 1995
    ..Through the cloning and characterization of an F9 cell cDNA we now show that the latter activity is Sox2, a member of the Sry-related Sox factors family...
  89. ncbi Mutations in SOX2 cause anophthalmia
    Judy Fantes
    MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Nat Genet 33:461-3. 2003
    A submicroscopic deletion containing SOX2 was identified at the 3q breakpoint in a child with t(3;11)(q26.3;p11.2) associated with bilateral anophthalmia...
  90. ncbi Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex
    David C Williams
    Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 0520, USA
    J Biol Chem 279:1449-57. 2004
    ..Upon binding of Sox2 to an adjacent site in the Hoxb1 regulatory element, all components of the ternary Oct1.Sox2...
  91. ncbi Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma
    Xue Ling Li
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    Int J Oncol 24:257-63. 2004
    b>SOX2, a SRY-related HMG box protein, is thought to be an important transcription factor during organogenesis, including the stomach although the expression and function are unclear...
  92. ncbi Bilateral anophthalmia and brain malformations caused by a 20-bp deletion in the SOX2 gene
    J C Zenteno
    Clin Genet 68:564-6. 2005
  93. ncbi Inhibition of DNA binding of Sox2 by the SUMO conjugation
    Shu Tsuruzoe
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 351:920-6. 2006
    b>Sox2 is a member of the high mobility group (HMG) domain DNA-binding proteins for transcriptional control and chromatin architecture...
  94. ncbi Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression
    Yasuyo Tani
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45, Yushima, Tokyo 113 8519, Japan
    J Cancer Res Clin Oncol 133:263-9. 2007
    b>Transcription factor SOX2 is expressed in normal gastric mucosae but not in the normal colon. We aimed to clarify the role of SOX2 with reference to pepsinogen expression in the gastrointestinal epithelium.
  95. ncbi Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer
    Socorro M Rodriguez-Pinilla
    Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Mod Pathol 20:474-81. 2007
    ..b>SOX2 is an embryonic transcription factor located at chromosome 3q, a region frequently gained in sporadic basal-like ..
  96. pmc Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal
    Boris Greber
    Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Berlin, Germany
    BMC Dev Biol 7:46. 2007
    ..To obtain further insights into the regulation of self-renewal, we have silenced hES/hEC cell-specific genes in NCCIT hEC cells and analysed the downstream effects by means of microarrays...
  97. pmc SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development
    Daniel Kelberman
    Developmental Endocrinology Research Unit, Clinical and Molecular Genetics Unit, Institute of Child Health, 30 Guilford Street, London, United Kingdom
    J Clin Endocrinol Metab 93:1865-73. 2008
    Heterozygous, de novo mutations in the transcription factor SOX2 are associated with bilateral anophthalmia or severe microphthalmia and hypopituitarism...
  98. doi Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation
    Marianna Sikorska
    Neurogenesis and Brain Repair Group, Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    J Neurosci Res 86:1680-93. 2008
    b>SOX2 is a key neurodevelopmental gene involved in maintaining the pluripotency of stem cells and proliferation of neural progenitors and astroglia...
  99. doi Novel SOX2 mutation associated with ocular coloboma in a Chinese family
    Panfeng Wang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Rd, Guangzhou 510060, China
    Arch Ophthalmol 126:709-13. 2008
    To report a novel SOX2 (OMIM 184429) mutation in a Chinese family and to describe its ocular and extraocular clinical features.
  100. pmc Familial recurrence of SOX2 anophthalmia syndrome: phenotypically normal mother with two affected daughters
    Adele Schneider
    Division of Genetics, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141, USA
    Am J Med Genet A 146:2794-8. 2008
    The SOX2 anophthalmia syndrome is emerging as a clinically recognizable disorder that has been identified in 10-15% of individuals with bilateral anophthalmia. Extra-ocular anomalies are common...
  101. pmc Complex architecture and regulated expression of the Sox2ot locus during vertebrate development
    Paulo P Amaral
    ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia
    RNA 15:2013-27. 2009
    The Sox2 gene is a key regulator of pluripotency embedded within an intron of a long noncoding RNA (ncRNA), termed Sox2 overlapping transcript (Sox2ot), which is transcribed in the same orientation...

Research Grants76

  1. TSHR and thyrocyte development
    Reigh Yi Lin; Fiscal Year: 2013
    ..into an ES cell-like state using the retrovirus-mediated transfection of four transcription factors (Oct4, Sox2, c-Myc, and Klf4)...
  2. Differentiating Nkx2.1-positive lung epithelial progenitors from ES cells
    Jayaraj Rajagopal; Fiscal Year: 2013
    ..We will use two complementary strategies to produce Nkx2.1-positive cells and more committed Nkx2.1+/Sox2+ airway progenitor cells...
  3. Herman S Cheung; Fiscal Year: 2014
    ..Our recent study showed that cells isolated from adult human PDL expressed ESC markers ( Oct4, Nanog, Sox2) and NC markers (p75, Nestin, Sox10), and exhibited the potential to differentiate into all 3 germ layers...
  4. Generation of Human iPS Cells via Non-integrating Vectors
    Wen Shu Wu; Fiscal Year: 2010
    ..pluripotent stem (iPS) cells by reprogramming of somatic cells via the defined transcription factors (Oct3/4 and Sox2 with Klf4 and c-Myc or Nanog and Lin28)...
  5. Function of KLF4-expressing stem cells in mouse cutaneous wound healing
    Walden Ai; Fiscal Year: 2013
    ..of induced pluripotent stem cells from well-differentiated fibroblasts with three other proteins, Oct4, c-myc, and Sox2. This proposal focuses on testing the hypothesis that KLF4- expressing stem cells have a critical function in mouse ..
  6. Cardiovascular and Therapeutic Potential of Reprogrammed Human Fibroblasts
    WILLIAM ROBB MACLELLAN; Fiscal Year: 2010
    ..of the pluripotency-associated POU domain class 5 transcription factor 1 (Oct3/4), SRY-box containing gene 2 (Sox2), proto-oncogene myc (c-Myc), and Kruppel-like factor 4 (Klf4) led to the generation of induced pluripotent stem (..
  7. Aging and Reprogramming of Somatic Cells to Pluripotency
    Peter J Hornsby; Fiscal Year: 2010
    ..This will be tested by the retroviral introduction of reprogramming genes (Oct4, Sox2, Klf4, with or without c-Myc) into skin fibroblasts from marmosets of a range of ages, newborn to very old (~13 ..
  8. JAMES ALEXANDER THOMSON; Fiscal Year: 2015
    ..Factors for Reprogramming/Transdifferentation," aims are: Design ATFs that activate expression of Oct4, Sox2 or Nanog in primary fibroblasts;Perform genome-wide location analysis, CSI and transcriptome analysis to determine ..
  9. miRNAs regulate lung epithelial progenitor cells in development and injury repair
    Ying Tian; Fiscal Year: 2013
    ..Overexpression of miR-302/367 in developing airway epithelium causes expansion of Sox2+ proximal and Sox9+ distal progenitor cells and decreased airway epithelial cell differentiation...
  10. Mana M Parast; Fiscal Year: 2014
    ..from these molar placentas and reprogram them into iPS cells using lenti- or Sendai virus expressing Klf4, Sox2, Oct4, and c-Myc...
  11. Matthew Thomson; Fiscal Year: 2016
    ..the ES cell, but, in previous research, I showed that a circuit of just two transcription factors, Oct4 and Sox2, controls germ layer fate selection...
  12. Marian L Waterman; Fiscal Year: 2016
    ..is a transcription factor that in mouse ESCs (mESCs) represses expression of master pluripotency factors Oct4, Sox2, and Nanog (OSN)...
  13. Ming Ming Zhou; Fiscal Year: 2014
    ..reprogramming of somatic cells to induced pluripotent stem cells using four transcription factors Oct3/4, Sox2, Klf4 and c-Myc (OSKM) highlights the ultimate control of cell fate by gene transcription...
  14. David L Spector; Fiscal Year: 2016
    ..The nuclear position of a series of 4 genes encoding the transcription factors Oct4, Nanog, Sox2, and Klf4 will be examined, as transcriptional silencing of these genes serves as a trigger for the initiation of ..
  15. Nuclear Reprogramming and Phenotype in Cloned Embryos
    Keith E Latham; Fiscal Year: 2013
    ..in vitro are mis-expressed in clones compared to fertilized embryos;Klf4 is over-expressed in cloned embryos, while Sox2 is under-expressed...
  16. Edward E Morrisey; Fiscal Year: 2015
    ..of Hdac1/2 causes severe defects in early proximal airway epithelial development including decreased maintenance of Sox2+ proximal progenitors accompanied by an increase in apoptosis...
  17. A Myc-centered network in embryonic stem cells and somatic cell reprogramming
    Jonghwan Kim; Fiscal Year: 2013
    ..Myc is one of the four transcription factors (Oct4, Sox2, Klf4, and Myc) used in generation of IPS cells and is a protein of interest due to its dual roles in the ..
  18. Generation of hPSCs Using Reprogramming Proteins-Encapsulated Nanoparticles
    Hsian Rong Tseng; Fiscal Year: 2012
    ..These NPs are capable of delivering reprogramming transcription factors (TFs), namely OCT4, SOX2, KLF4 and c-MYC...
  19. Optimal Generation and Characterization of iPS Cell Lines from Healthy and ADHD S
    Kwang Soo Kim; Fiscal Year: 2010
    ..e., Oct4, Sox2, Klf4 and c-Myc)...
  20. Optimal Generation and Characterization of iPS Cell Lines from Healthy and ADHD S
    Kwang Soo Kim; Fiscal Year: 2012
    ..e., Oct4, Sox2, Klf4 and c-Myc)...
  21. Max A Cayo; Fiscal Year: 2016
    ..Methods: We generate iPSC lines from human fibroblasts by lentiviral transduction (vectors encoding Oct4, Nanog, Sox2, Lin28) and validate the resulting iPSC by immunostaining/fluorescence microscopy, flow cytometry, DNA fingerprint ..
  22. TcdB Based Protein Delivery of iPSC Reprogramming Factors
    Yung Nien Chang; Fiscal Year: 2011
    ..We will then test if the engineered TcdB can deliver biologically active reprogramming factors (Oct4 and Sox2) to another reporter cell line and assess their ability to differentiate mouse embryonic stem cells with the help ..
  23. Role of OCT4 in reprogramming human skin keratinocytes
    Jackie R Bickenbach; Fiscal Year: 2012
    ..pluripotent through transduction with a retroviral vector carrying a cocktail of two embryonic genes, Oct4 and Sox2, and two cancer genes, Klf4 and c-myc...
  24. Neurons from pluripotent stem cells derived from schizophrenia patient fibroblast
    Russell L Margolis; Fiscal Year: 2010
    ..2, we will generate fibroblast cell lines form the skin biopsies, and then use retroviruses containing human Oc3/4, Sox2, Klf4, and c-Myc to generate pluripotent stem cells from the fibroblasts...
  25. Chandrakala Puligilla; Fiscal Year: 2014
    ..Recent studies have shown that the HMG class transcription factor Sox2 is dynamically expressed in prosensory cells and is required for the formation of this cell type...
  26. Development of a cell replacement therapy to treat retinal degenerative blindness
    BUDD ALBERT TUCKER; Fiscal Year: 2010
    ..produced via genetic reprogramming of dermal fibroblasts to pluripotency using the 4 transcription factors Oct4, Sox2, KLF4, and c-Myc, is of interest...
  27. Jeffrey H Kordower; Fiscal Year: 2016
    ..e., Oct4, Sox2, Klf4 and c-Myc)(Takahashi and Yamanaka, 2006)...
  28. Patricia Devaux; Fiscal Year: 2014
    ..virus can be modified into "one cycle" reprogramming vectors expressing the four reprogramming genes (OCT4, KFL4, SOX2 and cMYC)...
  29. A novel protein transduction method to generate induced pluripotent stem cells wi
    JAMES FREDERICK ELIASON; Fiscal Year: 2010
    ..The initial methods for reprogramming focused on delivery of four genes (Oct4, Sox2, and either Klf4 plus c-Myc, or NANOG plus Lin 28) using genetic transduction methods that potentially can create ..
  30. Generation of pluripotent cells by reprogramming of the somatic epigenome.
    GORDON GRANT WELSTEAD; Fiscal Year: 2010
    ..The recent discovery that four transcription factors: Oct4, Sox2, c-Myc and Klf4, can reprogram somatic fibroblasts into an embryonic-like pluripotent state has provided a ..
  31. Rajeshwar B Awatramani; Fiscal Year: 2014
    ..suggest that these SC are arrested at the promyelinating-myelinating transition, maintain the expression of Sox2, and lack the SC master regulator gene Egr2 (Krox20)...
  32. Pilar Blancafort; Fiscal Year: 2015
    ..The oncogenic TFs Sox2 is over-expressed in breast cancers of advanced stage, while the gene is silenced and hyper-methylated in normal ..
  33. Hainan Lang; Fiscal Year: 2016
    ..More recently, we have shown that acute SGN injury induces up-regulation of Sox2, a transcription factor that is highly expressed in undifferentiated neural cells during development and adult ..
  34. Elaine Fuchs; Fiscal Year: 2016
    ..in cultured embryonic stem cells (ESCs), Tcf3 is an integral component of the pluripotency regulatory complex (Sox2, Oct4, Nanog), not present in adult SCs...
  35. Brigid L M Hogan; Fiscal Year: 2016
    ..self-renewal and differentiation of basal stem cells, focusing initially on the role of the transcription factor, Sox2. Finally, in a high risk Aim 3, we will test the hypothesis that small non-coding RNAs known as microRNAs can ..
  36. Investigation of the Tip60-p400 complex role in embryonic stem cell self-ren
    Barbara Panning; Fiscal Year: 2012
    ..Several transcription factors, such as Oct4, Nanog, Sox2, Foxd3, and Stat3, are essential for self-renewal and pluripotency...
  37. Novel Roles of Pluripotency Regulators in the Early Mouse Embryo
    Wing H Wong; Fiscal Year: 2012
    ..In addition, our data suggest that the pluripotency regulators, Sox2 and Sall4, may also have critical functions prior to blastocyst formation...
  38. Development of Pluripotent Amniotic Stem Cell Banks for Disease Modeling
    JAMES FREDERICK ELIASON; Fiscal Year: 2011
    ..by applicant): Direct reprogramming of somatic cells with the transcription factors Oct4 (also called Pou5f1), Sox2, Klf4 and Myc1 yields induced Pluripotent Stem (iPS) cells with marked similarity to Embryonic Stem (ES) cells...
  39. Jianlong Wang; Fiscal Year: 2015
    ..The pluripotent ESC identity is governed by a set of transcription factors centered on Oct4, Sox2 and Nanog together with a number of epigenetic regulators...
  40. TGF-b family signaling in cardiomyocyte differentiation from embryonic stem cells
    RIK M DERYNCK; Fiscal Year: 2010
    ..Oct4, Sox2 and Nanog function as essential transcription factors for self-renewal and pluripotency, yet may also play key ..
  41. Alan P Fields; Fiscal Year: 2016
    ..signaling in NSCLC tumor-initiating cells;and 4) PKC? regulates recruitment of the stem cell pluripotency factor Sox2 to th promoter region of the gene encoding Hedgehog Acyl Transferase (HHAT), an enzyme that catalyzes a key step in ..
  42. A Myc-centered network in embryonic stem cells and somatic cell reprogramming
    Jonghwan Kim; Fiscal Year: 2010
    ..Myc is one of the four transcription factors (Oct4, Sox2, Klf4, and Myc) used in generation of iPS cells and Is a protein of interest due to its dual roles In the ..
  43. Sheng Ding; Fiscal Year: 2014
    ..g. Oct4, cMyc, Sox2 and Klf4)...
  44. Amy Ralston; Fiscal Year: 2016
    ..The transcription factors Oct4 (Pou5f1) and Sox2 are necessary for pluripotency in ES cells and are key regulators of induced pluripotency...
  45. Sai Hemanth Chavala; Fiscal Year: 2015
    ..b>SOX2 and PAX6 are transcription factors that are attractive candidates for regulating this pathway because they are ..
  46. Anthony S LaMantia; Fiscal Year: 2015
    ..Apparent embryonic OE stem cells express high levels of the transcription factor Meis1 as well as low levels of Sox2, divide slowly and symmetrically, and are necessary for the genesis of olfactory and vomeronasal receptor neurons (..
  47. John J Laterra; Fiscal Year: 2016
    ..Specific transcription factors (TFs) such as Sox2, Oct4, and Nanog, have essential roles in maintaining the stemness and proliferation potential of normal neural ..
  48. Elena Ezhkova; Fiscal Year: 2016
    ..The most prominent among them was Sox2, which encodes a transcription factor that is highly expressed in Merkel cells...
  49. KEVIN C EGGAN; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The combined activity of four transcription factors (Oct4, Sox2, cMyc and Klf4) can reprogram adult cells into induced pluripotent stem (iPS) cells...
  50. Small molecules that induce/promote generation of iPS cells
    Sheng Ding; Fiscal Year: 2010
    ..e. Oct4, cMyc, Sox2 and Klf4) together [5]...
  51. Defining factors associated with the conversion of primordial germ cells into plu
    Candace Kerr; Fiscal Year: 2009
    ..those containing sequence elements that may be responsive to known pluripotent factors such as Oct4, Nanog, or Sox2;and (4) finally, pathways shown to be relevant in pluripotent or multipotent cells...
  52. Michael Rendl; Fiscal Year: 2016
    ..In this proposal, we will utilize genetic drivers of DP genes Tbx18 and Sox2 to test the hypothesis that DP cells establish a niche for HF stem cells...
  53. Examining the Therapeutic Potential of iPS cells in Duchenne Muscular Dystrophy
    Rita C R Perlingeiro; Fiscal Year: 2010
    ..of direct reprogramming adult mouse and human fibroblasts toward a pluripotent state by introducing Oct3/4, Sox2, Klf4, and c-Myc, has brought new hope for the generation of patient- and disease- specific stem cells without the ..
  54. Bruce B Riley; Fiscal Year: 2016
    ..Additionally, various transcription factors belonging to the Pax2/5/8 and Sox2/3 families modify the response to Fgf to help establish different kinds of cell types...
  55. Genetic Basis of Congenital Anophthalmia
    THOMAS M GLASER; Fiscal Year: 2013
    ..Mutations in few genes have been identified, including transcription factors PAX6, CHX10, RX, SOX2 and OTX2, and growth factors GDF6 and BMP4...
  56. Bruce A Morgan; Fiscal Year: 2016
    ..A second is to characterize the role of a transcription factor, Sox2 that is expressed in the DP...
  57. FGF in sensory system development
    OLIVIA MARY BERMINGHAM MCDONOGH; Fiscal Year: 2010
    ..defined by p27 expression, is specified by the Notch pathway ligand, Jagged1, FGF receptor 1, and the transcription factor Sox2. Following specification, hair cells and supporting cells are defined within this region by a process ..
  58. The Role of transcription factor Sox2 in the homeostasis of the adult esophagus
    JIAN WEN QUE; Fiscal Year: 2013
    ..My previous studies using mouse models demonstrated that the transcription factor, Sox2, is essential for the normal development of the esophagus...
  59. Nabora Soledad Reyes de Mochel; Fiscal Year: 2014
    ..While the regulatory interactions and morphological contributions of transcription factors such as Oct3/4, Nanog, Sox2, Tead4, and Cdx2 have been extensively studied, surprisingly little is known about the roles of secreted growth ..
  60. Epigenetics, Stem Cells, and Cancer
    Rudolf Jaenisch; Fiscal Year: 2010
    ..Oct4 is a pluripotency gene that in combination with Nanog and Sox2 controls the self-renewal of embryonic stem cells...
  61. Shoukhrat M Mitalipov; Fiscal Year: 2014
    ..examine a cumulative impact of the TE inactivation along with upregulation of critical pluripotent factors - Oct4, Sox2, and Nanog - on reprogramming and derivation of ESCs. Aim 2...
  62. New Multiplexed Quantitative Detection of Pluripotency and Germ Layer Proteins
    Bradley H Garcia; Fiscal Year: 2011
    ..by identifying matched pairs of antibodies (working sandwich assays) for four key pluripotency targets: Sox2, Oct4, Nanog and Rex1...
  63. Epigenetics of Dental Stem Cells: Markers and CP27 Function
    Xianghong Luan; Fiscal Year: 2010
    ..exchange and ES cell pluripotency network maintenance, including transcriptional regulators such as Nanog and Sox2. In order to explain the effect of CP27 on chromatin-mediated gene regulation mechanisms, the variant histone H2A...
  64. Dieter C Gruenert; Fiscal Year: 2015
    ..cells using phiC31 Integrase-mediated, sequence-specific integration of a plasmid carrying 2A peptide linked Oct4, Sox2, Klf4, and cMyc reprogramming cDNAs or by using small activating double stranded RNA (saRNA) to transiently enhance ..
  65. Jonathan S Weissman; Fiscal Year: 2016
    ..Specifically, we will modify the epigenetic marks of the murine Oct4 and Sox2 loci as the endogenous experimental testbed, and study the importance of modifier recruitment positioning and ..
  66. Guojun Wu; Fiscal Year: 2016
    ..PSC (piPSC) technique that reprogrammed heterogeneous malignant Breast Cancer Cells (malBCCs) into piPSCs using the Sox2/Oct4/Nanog (SON) proteins with 90[unreadable]4% conversion...
  67. Jimmy Kuang Hsien Hu; Fiscal Year: 2015
    ..specifically in the incisor stem cell population by removing MST1/2 or SAV, key components of the pathway, using Sox2-Cre...
  68. Plasticity and Regulation in Xenopus Anterior-Posterior Patterning
    Margaret S Saha; Fiscal Year: 2013
    ..differentiation genes (GAD, xvGlut1);genes expressed earlier in the neural determination pathway (FoxD5, Geminin, Sox2);and genes encoding key anterior-posterior signaling molecules (Frzb-1, xWnt8, and FGF8)...
  69. Transduction of cells with transcription factors to achieve nuclear reprogramming
    Hidde Ploegh; Fiscal Year: 2009
    ..to endow them with pluripotent stem cell-like properties by delivery of the necessary transcription factors (Oct4, Sox2, c-Myc and Klf4) in cell-permeable form...
  70. Sadhan Majumder; Fiscal Year: 2015
    ..We have discovered a new regulatory axis based on a novel miR-21-Sox2 axis in GBM patients and patient glioblastoma-derived stem cells through bioinformatic and biochemical studies...
  71. Michael A Dyer; Fiscal Year: 2016
    ..system to quantify the epigenetic reprogramming of individual retinal neurons by using 4 factors (Oct4, Klf4, Sox2, and Myc) and somatic cell nuclear transfer...
  72. Konrad Hochedlinger; Fiscal Year: 2015
    ..We have recently identified rare Sox2+ cells in the antrum and corpus of mice...
  73. MECHANISMS OF FGF RESPONSES IN OSTEOGENIC CELLS
    Claudio Basilico; Fiscal Year: 2009
    ..We have also observed a striking induction of the expression of Sox2, a member of the HMG domain family of transcription factors, and shown that constitutive expression of Sox2 can ..
  74. Zebrafish Lateral Line Enhancer Elucidation via Comparative Genomics and Transge
    NICHOLAS COLEY; Fiscal Year: 2009
    Empirical evidence exists for a genetic hierarchy of sox2/sox3>atonal>and brnSc in the neural induction and patterning of the otic placode (sox2/sox3) of and the subsequent neural differentiation of mechanosensory structures from ..
  75. Roles of Lin-28 and miRNAs in direct reprogramming of human fibroblasts
    Kathleen Worringer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) or Oct4, Sox2, Nanog, and Lin-28 in fibroblasts can "reprogram" them to become induced pluripotent stem (iPS) cells, which are highly similar to ..
  76. REGULATION OF FGF-4 GENE EXPRESSION IN DEVELOPMENT
    Claudio Basilico; Fiscal Year: 2003
    ..This element interacts with two specific transcriptional regulators, Sox2 and Oct-3, which are coexpressed in EC and ES cells, and in the inner cells mass (ICM) of the blastocyst, the first ..