SPINK1

Summary

Gene Symbol: SPINK1
Description: serine peptidase inhibitor, Kazal type 1
Alias: PCTT, PSTI, Spink3, TATI, TCP, serine protease inhibitor Kazal-type 1, pancreatic secretory trypsin inhibitor, serine protease inhibitor, Kazal type 1, tumor-associated trypsin inhibitor
Species: human

Top Publications

  1. ncbi Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer
    M L Huhtala
    J Biol Chem 257:13713-6. 1982
  2. ncbi Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis
    Eija Tukiainen
    Second Department of Surgery, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Pancreas 30:239-42. 2005
  3. pmc The role of SPINK1 in ETS rearrangement-negative prostate cancers
    Scott A Tomlins
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 13:519-28. 2008
  4. ncbi Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene
    A Horii
    Institute for Molecular and Cellular Biology, Osaka University, Suita, Japan
    Biochem Biophys Res Commun 149:635-41. 1987
  5. pmc Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis
    J M Chen
    J Med Genet 37:67-9. 2000
  6. ncbi Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
    H Witt
    Department of Pediatrics, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Nat Genet 25:213-6. 2000
  7. ncbi SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis
    R H Pfützer
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Gastroenterology 119:615-23. 2000
  8. ncbi Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants
    Niels Teich
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Germany
    Am J Gastroenterol 97:341-6. 2002
  9. ncbi Determination of the relative contribution of three genes-the cystic fibrosis transmembrane conductance regulator gene, the cationic trypsinogen gene, and the pancreatic secretory trypsin inhibitor gene-to the etiology of idiopathic chronic pancreatitis
    Marie Pierre Audrezet
    INSERM EMI 01 15, Génétique Moléculaire et Génétique Epidémiologique, Centre Hospitalier Universitaire, Brest, France
    Eur J Hum Genet 10:100-6. 2002
  10. pmc The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease
    J Threadgold
    Department of Surgery, University of Liverpool, 5th Floor UCD Building, Daulby Street, Liverpool L69 3GA, UK
    Gut 50:675-81. 2002

Research Grants

  1. Role of Pancreatic Trypsin Inhibitors in Pancreatic
    Rodger A Liddle; Fiscal Year: 2010
  2. Andrew S Levey; Fiscal Year: 2014
  3. NAPS2 Continuation Genome Wide Association Study of Pancreatitis
    DAVID CLEMENT WHITCOMB; Fiscal Year: 2011
  4. Genetic Epidemiology of Young-Onset Pancreatic Cancer
    Robert R McWilliams; Fiscal Year: 2010
  5. CARLOS TORRES MORAES; Fiscal Year: 2016
  6. Evette S Radisky; Fiscal Year: 2014
  7. Optical Encoding Technology for Viral Screening Panels
    ROBERT HAUSHALTER; Fiscal Year: 2009
  8. 14th Internatinal Symposium on Inherited Diseases
    David Whitcomb; Fiscal Year: 2004
  9. NAPS2 Continuation - Genome-Wide Association Study of Pancreatitis
    David C Whitcomb; Fiscal Year: 2010
  10. MOLECULAR GENETICS OF HEREDITARY PANCREATITIS
    David Whitcomb; Fiscal Year: 2008

Detail Information

Publications195 found, 100 shown here

  1. ncbi Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer
    M L Huhtala
    J Biol Chem 257:13713-6. 1982
    ..The 21 residues determined were found to be identical with the corresponding ones of human pancreatic trypsin inhibitor. The purified peptide also inhibited bovine trypsin effectively...
  2. ncbi Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis
    Eija Tukiainen
    Second Department of Surgery, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Pancreas 30:239-42. 2005
    Mutations in the secretory trypsin inhibitor (SPINK1) gene have been found to be associated with hereditary and chronic pancreatitis. There are no previous reports on SPINK1 mutations in patients with acute pancreatitis (AP).
  3. pmc The role of SPINK1 in ETS rearrangement-negative prostate cancers
    Scott A Tomlins
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 13:519-28. 2008
    ..Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS rearrangement-negative cancers ( approximately 10% of total ..
  4. ncbi Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene
    A Horii
    Institute for Molecular and Cellular Biology, Osaka University, Suita, Japan
    Biochem Biophys Res Commun 149:635-41. 1987
    The human pancreatic secretory trypsin inhibitor (PSTI) gene was isolated from a human gene library. Restriction endonuclease mapping and DNA sequencing analysis revealed that this gene is approximately 7...
  5. pmc Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis
    J M Chen
    J Med Genet 37:67-9. 2000
  6. ncbi Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
    H Witt
    Department of Pediatrics, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Nat Genet 25:213-6. 2000
    ..children and adolescents with CP for mutations in the gene encoding the serine protease inhibitor, Kazal type 1 (SPINK1), a pancreatic trypsin inhibitor. We found mutations in 23% of the patients...
  7. ncbi SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis
    R H Pfützer
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Gastroenterology 119:615-23. 2000
    ..Loss of trypsin inhibitor function may have similar effects. We investigated the prevalence of SPINK1 (PSTI) mutations in familial pancreatitis, idiopathic chronic pancreatitis, and controls.
  8. ncbi Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants
    Niels Teich
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Germany
    Am J Gastroenterol 97:341-6. 2002
    ..After mutational screening of a cohort of patients with nonalcoholic chronic pancreatitis, we report three novel variants of the trypsinogen molecule and the clinical characteristics of the carriers...
  9. ncbi Determination of the relative contribution of three genes-the cystic fibrosis transmembrane conductance regulator gene, the cationic trypsinogen gene, and the pancreatic secretory trypsin inhibitor gene-to the etiology of idiopathic chronic pancreatitis
    Marie Pierre Audrezet
    INSERM EMI 01 15, Génétique Moléculaire et Génétique Epidémiologique, Centre Hospitalier Universitaire, Brest, France
    Eur J Hum Genet 10:100-6. 2002
    ..transmembrane conductance regulator (CFTR) gene, the cationic trypsinogen (PRSS1) gene, and the pancreatic secretory trypsin inhibitor (PSTI) gene, have been found to be associated with chronic pancreatitis (CP)...
  10. pmc The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease
    J Threadgold
    Department of Surgery, University of Liverpool, 5th Floor UCD Building, Daulby Street, Liverpool L69 3GA, UK
    Gut 50:675-81. 2002
    ..Recently, an association between the mutation N34S in the pancreatic secretory trypsin inhibitor (SPINK1 or PSTI) gene and idiopathic chronic pancreatitis (ICP) was reported...
  11. pmc Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis
    J P H Drenth
    Department of Medicine, Division of Gastroenterology and Hepatology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Gut 50:687-92. 2002
    ..As serine protease inhibitor Kazal type 1 (SPINK1) is a potent natural inhibitor of pancreatic trypsin activity, we hypothesised that SPINK1 ..
  12. pmc Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis
    G R Chandak
    J Med Genet 39:347-51. 2002
  13. pmc SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent
    Zahid Hassan
    Barts and The London Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Am J Hum Genet 71:964-8. 2002
    ..Since the N34S variant of the SPINK1 trypsin inhibitor gene has been found to partially account for genetic susceptibility to chronic pancreatitis, we ..
  14. ncbi Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations
    Eesh Bhatia
    Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Gastroenterology 123:1020-5. 2002
    ..In the present study we report on mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) gene in north Indian patients with TCP.
  15. ncbi SPINK1/PSTI mutations are associated with tropical pancreatitis and type II diabetes mellitus in Bangladesh
    Alexander Schneider
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Gastroenterology 123:1026-30. 2002
    ..In a preliminary study, we found serine protease inhibitor, Kazal type 1 (SPINK1) mutations in 6 of 8 patients with fibrocalculous pancreatic diabetes in Bangladesh...
  16. ncbi Germline mutations in CFTR and PSTI genes in chronic pancreatitis patients
    Ezio Gaia
    Struttura Complessa di Gastroenterologia, Dipartimento di Clinica Medica, Azienda Ospedaliera San Luigi Gonzaga, Torino, Italy
    Dig Dis Sci 47:2416-21. 2002
    ..cystic fibrosis transmembrane conductance regulator (CFTR) and pancreatic secretory trypsinogen inhibitor (PSTI) genes have recently been associated with chronic pancreatitis...
  17. ncbi Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States
    Alexander Schneider
    Department of Medicine, Division of Gastroenterology, Center for Genomic Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Dig Dis Sci 48:1110-5. 2003
    Mutations in the SPINK1 gene (e.g. N34S) have been reported in patients with idiopathic, familial, tropical, and alcoholic pancreatitis...
  18. ncbi Mutations in the SPINK1 gene in idiopathic pancreatitis Italian patients
    Macarena Gomez-Lira
    Section of Biology and Genetics, Department of Mother and Child, Biology and Genetics, University of Verona, Verona, Italy
    Eur J Hum Genet 11:543-6. 2003
    ..Mutations in the serine protease inhibitor Kazal 1 (SPINK1) have been described in some idiopathic chronic patients and it has been suggested that mutations in this gene ..
  19. ncbi Mutation analysis of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the cationic trypsinogen (PRSS1) gene, and the serine protease inhibitor, Kazal type 1 (SPINK1) gene in patients with alcoholic chronic pancreatitis
    Francesco Perri
    Division of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, 71013 San Giovanni Rotondo 1, Italy
    Eur J Hum Genet 11:687-92. 2003
    ..PRSS1), cystic fibrosis transmembrane conductance regulator (CFTR), and serine protease inhibitor, Kazal type 1 (SPINK1) genes have been variably associated with both the hereditary and the idiopathic form of chronic pancreatitis (CP)...
  20. ncbi Co-expression of trypsin and tumour-associated trypsin inhibitor (TATI) in colorectal adenocarcinomas
    S Solakidi
    Institute of Biological Research, National Hellenic Research Foundation, Athens, Greece
    Histol Histopathol 18:1181-8. 2003
    Trypsin and its specific inhibitor, TATI (tumour-associated trypsin inhibitor), are expressed in normal human pancreas and in a variety of tumours...
  21. ncbi CFTR, PRSS1 and SPINK1 mutations in the development of pancreatitis in Brazilian patients
    Andrea L Ferreira Bernardino
    Human Genome Research Center, University of Sao Paulo, Sao Paulo, Brazil
    JOP 4:169-77. 2003
    ..cystic fibrosis transmembrane conductance regulator (CFTR), in cationic trypsinogen (PRSS1) and in serine protease inhibitor Kazal type 1 (SPINK1) genes have been associated with chronic pancreatitis (alcohol related, idiopathic and ..
  22. ncbi Tumour-associated trypsin inhibitor, carcinoembryonic antigen and acute-phase reactant proteins CRP and alpha1-antitrypsin in patients with gastrointestinal malignancies
    Sylvia Solakidi
    Institute of Biological Research, National Hellenic Research Foundation, 116 35 Athens, Greece
    Clin Biochem 37:56-60. 2004
    Elevated serum tumour-associated trypsin inhibitor (TATI) levels have been observed in association with malignancy or inflammation. The aim of our study was to evaluate the role of TATI in gastric and colorectal cancer.
  23. ncbi Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer
    Hiroyuki Matsubayashi
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Cancer Biol Ther 2:652-5. 2003
    ..Inheritance of polymorphisms in SPINK1 and CFTR are associated with an increased risk of developing pancreatitis...
  24. ncbi Two novel severe mutations in the pancreatic secretory trypsin inhibitor gene (SPINK1) cause familial and/or hereditary pancreatitis
    C Le Marechal
    INSERM 01 15, Génétique Moléculaire et Génétique Epidémiologique, Établissement Français du sang Bretagne, Universite de Bretagne Occidentale, Centre Hospitalier Universitaire de Morvan, Brest, France
    Hum Mutat 23:205. 2004
    Mutations in the serine protease inhibitor Kazal type 1 gene (SPINK1) encoding pancreatic secretory trypsin inhibitor (PSTI) have recently been found to be associated with chronic pancreatitis...
  25. pmc Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis
    G R Chandak
    Genome Research Group, Centre for Cellular and Molecular Biology, Hyderabad, India
    Gut 53:723-8. 2004
    ..As a modifier role has been proposed for trypsin inhibitor (serine protease inhibitor, Kazal type I; SPINK1) mutations, the role of SPINK1 mutations in these patients was also analysed.
  26. ncbi Mutations N34S and P55S of the SPINK1 gene in patients with chronic pancreatitis or pancreatic cancer and in healthy subjects: a report from Finland
    Marko Lempinen
    Fourth Department of Surgery, Helsinki University Central Hospital, FI 00029 Helsinki, Finland
    Scand J Gastroenterol 40:225-30. 2005
    Mutations in the Kazal type 1 serine protease inhibitor (SPINK1) gene have recently been associated with chronic pancreatitis (CP), an established risk factor for pancreatic cancer...
  27. ncbi High tissue expression of tumour-associated trypsin inhibitor (TATI) associates with a more favourable prognosis in gastric cancer
    J P Wiksten
    Department of Surgery, University of Helsinki, Helsinki, Finland
    Histopathology 46:380-8. 2005
    The tumour-associated trypsin inhibitor (TATI) is a 6-kDa protease inhibitor with potential inhibitory effects on tissue degradation. In serum, increased levels have been associated with adverse prognosis in different forms of cancer...
  28. ncbi Mutation analysis of SPINK1 and CFTR gene in Korean patients with alcoholic chronic pancreatitis
    Kwang Hyuck Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Liver Research Institute, Seoul, Korea
    Dig Dis Sci 50:1852-6. 2005
    ..However, their roles in alcoholic chronic pancreatitis are controversial. We investigated the prevalence of SPINK1 N34S and new CFTR Q1352H mutations in alcoholic chronic pancreatitis in Korea...
  29. ncbi Differential expression of trypsinogen and tumor-associated trypsin inhibitor (TATI) in bladder cancer
    K Hotakainen
    Department of Clinical Chemistry, Helsinki University Central Hospital, FIN 00029, Helsinki, Finland
    Int J Oncol 28:95-101. 2006
    Tumor-associated trypsin inhibitor (TATI) is a marker of mucinous ovarian carcinoma, but it is also widely expressed in other malignant tumors and normal human tissues...
  30. ncbi Detection of a large genomic deletion in the pancreatic secretory trypsin inhibitor (SPINK1) gene
    Emmanuelle Masson
    INSERM, U613, 29220 Brest, France
    Eur J Hum Genet 14:1204-8. 2006
    Mutations and polymorphisms in the SPINK1 gene, which encodes trypsin's physiological inhibitor, pancreatic secretory trypsin inhibitor, have been found to be associated with chronic pancreatitis...
  31. ncbi SPINK1 gene mutations and pancreatitis in Japan
    Tooru Shimosegawa
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Gastroenterol Hepatol 21:S47-51. 2006
    b>SPINK1 can inhibit up to 20% of trypsin activity, and may constitute one major mechanism to protect the pancreas from autodigestion. In 2000, Witt et al...
  32. ncbi Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis
    Steven Keiles
    Ambry Genetics, Aliso Viejo, CA 92656, USA
    Pancreas 33:221-7. 2006
    ..Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) and the serine protease inhibitor Kazal type 1 (SPINK1) genes are also associated with pancreatitis.
  33. ncbi Differential roles of the SPINK1 gene mutations in alcoholic and nonalcoholic chronic pancreatitis
    Atsushi Masamune
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Gastroenterol 42:135-40. 2007
    ..We here examined the prevalence of the serine protease inhibitor Kazal type 1 (SPINK1) gene mutations in Japanese patients with CP, and whether the disease course was different ..
  34. ncbi Contribution of the CFTR gene, the pancreatic secretory trypsin inhibitor gene (SPINK1) and the cationic trypsinogen gene (PRSS1) to the etiology of recurrent pancreatitis
    M Tzetis
    Department of Medical Genetics, Medical School, Athens University, Athens, Greece
    Clin Genet 71:451-7. 2007
    ..486C/T and c.738C/T were found in nine patients each, three homozygotes for the minor alleles. Two carried SPINK1 gene mutation p.N34S, one being transheterozygote with CFTR mutation p.F1052V...
  35. pmc Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation
    Orsolya Kiraly
    Department of Molecular and Cell Biology, Boston University, Goldman School of Dental Medicine, Boston, MA, USA
    Gut 56:1433-8. 2007
    Mutations of the SPINK1 gene encoding pancreatic secretory trypsin inhibitor have been identified in association with chronic pancreatitis...
  36. ncbi Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene
    Arnaud Boulling
    INSERM, U613, Établissement Français du sang Bretagne, Brest 29220, France
    Eur J Hum Genet 15:936-42. 2007
    Variations in the SPINK1 gene (encoding pancreatic secretory trypsin inhibitor (PSTI)) are associated with chronic pancreatitis...
  37. ncbi Co-inheritance of a novel deletion of the entire SPINK1 gene with a CFTR missense mutation (L997F) in a family with chronic pancreatitis
    Emmanuelle Masson
    INSERM, U613, 29220 Brest, France
    Mol Genet Metab 92:168-75. 2007
    ..was established in order to make possible the rapid and efficient mutational analysis of the pancreatic secretory trypsin inhibitor (SPINK1) gene...
  38. doi Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells
    V Gouyer
    Centre de Recherche Jean Pierre Aubert, U837, Faculte de Medecine, Lille, France
    Oncogene 27:4024-33. 2008
    ..cells, HT-29 5M21 (CM-5M21), expressing a spontaneous invasive phenotype, tumor-associated trypsin inhibitor (TATI) was identified and characterized by proteomics, cDNA microarray approaches and functional analyses...
  39. doi Tumor-associated protein SPIK/TATI suppresses serine protease dependent cell apoptosis
    Xuanyong Lu
    Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, College of Medicine, Drexel University, 3805 Old Easton Road, Doylestown, PA 18902, USA
    Apoptosis 13:483-94. 2008
    ..Here, we show that over-expression of a cellular protein called serine protease inhibitor Kazal (SPIK/TATI/PSTI) results in a significant decrease in cell susceptibility to SPDCA, suggesting that SPIK is an apoptosis inhibitor ..
  40. pmc Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis
    Elie Aoun
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 3:e2003. 2008
    ..interactions between recurrent trypsin-mediated pancreatic injury, alcohol-associated pancreatic injury and SPINK1 polymorphisms in chronic pancreatitis (CP) are undefined...
  41. pmc Minigene analysis of intronic variants in common SPINK1 haplotypes associated with chronic pancreatitis
    E Kereszturi
    Department of Molecular and Cell Biology, Boston University Goldman School of Dental Medicine, Boston, Massachusetts, USA
    Gut 58:545-9. 2009
    Two common haplotypes of the serine protease inhibitor Kazal type 1 (SPINK1) gene have been shown to increase the risk for chronic pancreatitis. A haplotype comprising the c.101A>G (p...
  42. doi Pancreatic secretory trypsin inhibitor is a major motogenic and protective factor in human breast milk
    Tania Marchbank
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, and Queen Charlotte s Hospital, Turner St, London E1 2AD, UK
    Am J Physiol Gastrointest Liver Physiol 296:G697-703. 2009
    ..We examined whether human colostrum and milk contained pancreatic secretory trypsin inhibitor (PSTI), a peptide of potential relevance for mucosal defense and, using in vitro and in vivo ..
  43. pmc High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer
    A Gaber
    Department of Laboratory Medicine, Center for Molecular Pathology, Malmo University Hospital, Lund University, Malmo, Sweden
    Br J Cancer 100:1540-8. 2009
    Increased expression of tumour-associated trypsin inhibitor (TATI) in tumour tissue and/or serum has been associated with poor survival in various cancer forms...
  44. doi Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants
    Monique H M Derikx
    Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands
    Eur J Gastroenterol Hepatol 21:889-94. 2009
    ..The SPINK1 variant p.N34S is strongly associated with TCP, but other genetic factors remain to be defined...
  45. pmc Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma
    Bo Han
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mod Pathol 22:1176-85. 2009
    ..b>SPINK1, a biomarker expressed exclusively in a subset of ETS negative prostate carcinomas, was expressed in 6% of ETS ..
  46. doi Genetic mutations in a Spanish population with chronic pancreatitis
    Josefina Mora
    Department of Clinical Chemistry, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Pancreatology 9:644-51. 2009
    Mutations in the PRSS1 and the SPINK1 genes have variably been associated with alcohol-related, idiopathic and hereditary chronic pancreatitis (CP)...
  47. pmc Hepatitis B and hepatitis C virus replication upregulates serine protease inhibitor Kazal, resulting in cellular resistance to serine protease-dependent apoptosis
    Jason Lamontagne
    Drexel Institute for Biotechnology and Virology Research, Department of Microbiology, Drexel University, 3805 Old Easton Road, Doylestown, PA 18902, USA
    J Virol 84:907-17. 2010
    ..These findings suggest a possibility by which HBV and HCV, two very different viruses, can share a common mechanism in provoking liver disease and cancer...
  48. doi Association of SPINK1 expression and TMPRSS2:ERG fusion with prognosis in endocrine-treated prostate cancer
    Katri A Leinonen
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Department of Urology, Tampere University Hospital, Tampere, Finland
    Clin Cancer Res 16:2845-51. 2010
    The aim of the study was to examine whether TMPRSS2:ERG fusion or SPINK1 protein expression is associated with hormone responsiveness of prostate cancer and can thus be used as a biomarker.
  49. ncbi Phenotypic variability of the homozygous IVS3+2T>C mutation in the serine protease inhibitor Kazal type 1 (SPINK1) gene in patients with chronic pancreatitis
    Yuji Ota
    Department of Gastroenterology, Hamamatsu Rosai Hospital
    Tohoku J Exp Med 221:197-201. 2010
    ..Recent studies have shown an association between mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene and CP...
  50. doi Idiopathic chronic pancreatitis in India: phenotypic characterisation and strong genetic susceptibility due to SPINK1 and CFTR gene mutations
    Shallu Midha
    Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110029, India
    Gut 59:800-7. 2010
    ..To study the genetic predisposition, phenotype and prognosis of idiopathic chronic pancreatitis (CP)...
  51. pmc Increased serum levels of tumour-associated trypsin inhibitor independently predict a poor prognosis in colorectal cancer patients
    Alexander Gaber
    Department of Laboratory Medicine, Lund University, Skane University Hospital, Center for Molecular Pathology, Malmo, Sweden
    BMC Cancer 10:498. 2010
    ..In a previous study, we found that high tumour tissue expression of tumour-associated trypsin inhibitor (TATI) correlated with liver metastasis and an impaired prognosis in CRC...
  52. pmc Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis
    Alexander Schneider
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gastroenterology 140:162-71. 2011
    ..We investigated whether sequence variants in the gene encoding the pancreatic secretory trypsin inhibitor SPINK1 further increase the risk of pancreatitis in these patients.
  53. pmc Combined genomic and phenotype screening reveals secretory factor SPINK1 as an invasion and survival factor associated with patient prognosis in breast cancer
    Wendy Weijia Soon
    Cancer Biology and Pharmacology, Genome Institute of Singapore
    EMBO Mol Med 3:451-64. 2011
    ..We identified Serine protease inhibitor Kazal-type 1 (SPINK1) to be associated with poor survival in estrogen receptor-positive (ER+) cases...
  54. doi CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?
    Jonas Rosendahl
    Department for Paediatrics and Else Kröner Fresenius Zentrum EKFZ, Technical University Munich TUM, Gregor Mendel Str 2, 85350 Freising, Germany
    Gut 62:582-92. 2013
    ..In chronic pancreatitis (CP), alterations in several genes have so far been described, but only small cohorts have been extensively investigated for all predisposing genes...
  55. doi Tumour-associated trypsin inhibitor TATI is a prognostic marker in colorectal cancer
    Selja Koskensalo
    Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Oncology 82:234-41. 2012
    The tumour-associated trypsin inhibitor TATI is expressed together with trypsin in many cancer forms, and an elevated serum level associates with poor prognosis...
  56. ncbi SPINK1 mutations are associated with multiple phenotypes
    R H Pfützer
    Department of Medicine II, University Hospital of Heidelberg at Mannheim, Germany
    Pancreatology 1:457-60. 2001
    Mutations in the gene encoding for the pancreatic secretory trypsin inhibitor or serine protease inhibitor, Kazal type I (SPINK1) have been associated with different entities of chronic pancreatitis...
  57. ncbi Mutations in the serine protease inhibitor Kazal Type 1 (SPINK1) gene in Japanese patients with pancreatitis
    Kiyoshi Kume
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreatology 5:354-60. 2005
    Recent studies have shown an association between the N34S mutation in the serine protease inhibitor Kazal type 1 (SPINK1) gene and chronic pancreatitis (CP)...
  58. ncbi Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair
    T Marchbank
    University Division of Gastroenterology, Leicester General Hospital NHS Trust, UK
    Digestion 59:167-74. 1998
    b>Pancreatic secretory trypsin inhibitor is a potent protease inhibitor which was originally identified in the pancreas...
  59. ncbi Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis
    K Kaneko
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Hum Genet 46:293-7. 2001
    ..Recently, the N34S alteration of the pancreatic secretory trypsin inhibitor (PSTI) gene has been suggested to be closely associated with the pathogenesis of hereditary and/or ..
  60. ncbi Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis
    Kaspar Truninger
    Department of Medicine II, University of Freiburg, Germany
    Am J Gastroenterol 97:1133-7. 2002
    ..Recently, a point mutation (N34S) in the gene encoding the serine protease inhibitor, Kazal type 1 (SPINK1), was found in approximately 20% of patients with CP...
  61. ncbi Analysis of CFTR, SPINK1, PRSS1 and AAT mutations in children with acute or chronic pancreatitis
    Agnieszka Sobczynska-Tomaszewska
    Department of Medical Genetics, Institute of Mother and Child, Warsaw, Poland
    J Pediatr Gastroenterol Nutr 43:299-306. 2006
    Defects of PRSS1, SPINK1, CFTR and AAT are considered causative or predisposing to pancreatitis...
  62. ncbi Expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor in ovarian cancer: prognostic study on tissue and serum
    Annukka Paju
    Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland
    Clin Cancer Res 10:4761-8. 2004
    ..significance of tissue expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor (TATI) and serum concentration of trypsinogen-2, trypsin-2-API (complex of trypsin-2 with alpha-1-proteinase inhibitor), ..
  63. ncbi [Chronic pancreatitis--pancreas cancer: influence of genetic factors]
    V Keim
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig AoR
    Praxis (Bern 1994) 94:811-7. 2005
    ..In this group of patients the mutation N34S of the trypsin inhibitor SPINK1 was detected...
  64. ncbi Expression and functional analysis of rat P23, a gut hormone-inducible isoform of trypsin, reveals its resistance to proteinaceous trypsin inhibitors
    Shin Ichi Fukuoka
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611, Japan
    Biochim Biophys Acta 1588:106-12. 2002
    ..Interestingly, rat pancreatic secretory trypsin inhibitor (PSTI), which protects against deleterious activation of trypsinogens in zymogen granules, failed ..
  65. ncbi Tumor-associated trypsinogen-2 (trypsinogen-2) activates procollagenases (MMP-1, -8, -13) and stromelysin-1 (MMP-3) and degrades type I collagen
    Merja Moilanen
    Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland
    Biochemistry 42:5414-20. 2003
    ..These proMMP activations are inhibited by tumor-associated trypsin inhibitor (TATI)...
  66. pmc Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype
    Joelle M J Romac
    Department of Medicine, Duke University, Durham, NC 27710, USA
    Am J Physiol Gastrointest Liver Physiol 298:G518-24. 2010
    ..Rodent trypsin inhibitors are highly homologous to human serine protease inhibitor Kazal-type 1 (SPINK1)...
  67. ncbi Genetic aspects of chronic pancreatitis: insights into aetiopathogenesis and clinical implications
    K Truninger
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Swiss Med Wkly 131:565-74. 2001
    ..Two different protective mechanisms prevent activation of the pancreatic digestive enzyme cascade. First, SPINK1 inhibits up to 20% of potential trypsin activity and, second, trypsin itself activates trypsin-like enzymes ..
  68. ncbi Relevance of variants in serum antiproteinases for the course of chronic pancreatitis
    N Teich
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Germany
    Scand J Gastroenterol 37:360-5. 2002
    Mutations of the pancreatic serine protease inhibitor, Kazal type 1 (SPINK1), the cationic trypsinogen (PRSS1) and the cystic fibrosis transmembrane conductance regulator (CFTR) were reported to be genetic risk factors of chronic ..
  69. ncbi Tumor-associated trypsin inhibitor in normal and malignant renal tissue and in serum of renal-cell carcinoma patients
    A Lukkonen
    Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland
    Int J Cancer 83:486-90. 1999
    Tumor-associated trypsin inhibitor (TATI) is a 6-kDa peptide, which is identical to the pancreatic-secretory-trypsin inhibitor (PSTI)...
  70. ncbi Common protein-binding sites in the 5'-flanking regions of human genes for cytochrome c1 and ubiquinone-binding protein
    H Suzuki
    Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan
    J Biol Chem 265:8159-63. 1990
    ..in the 280-base pair BamHI-HindIII fragment of the ubiquinone-binding protein gene and in the 154-base pair SalI-PstI fragment of the cytochrome c1 gene...
  71. pmc Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue
    Mathias Stenman
    Department of Anatomy, Institute of Biomedicine, Helsinki, Finland
    Am J Pathol 167:1119-24. 2005
    ..Thus, trypsin-2 and its regulators should be further studied for use as markers of prognosis and disease activity in rheumatoid arthritis...
  72. ncbi Trypsinogen-1, -2 and tumour-associated trypsin-inhibitor in bile and biliary tract tissues from patients with biliary tract diseases and pancreatic carcinomas
    J Hedstrom
    Department of Clinical Chemistry, University of Helsinki, Finland
    Scand J Clin Lab Invest 61:111-8. 2001
    The bile concentrations of trypsinogen-1, -2 and tumour-associated trypsin-inhibitor (TATI) were determined in 23 patients with benign biliary tract disease, two with biliary tract cancer, and in 15 with pancreatic cancer...
  73. ncbi The course of genetically determined chronic pancreatitis
    Volker Keim
    Medizinische Klinik II, Universitatsklinikum Leipzig, Germany
    JOP 4:146-54. 2003
    The clinical course of chronic pancreatitis in patients with mutations of cationic trypsinogen and the trypsin inhibitor SPINK1 has not yet been characterized.
  74. pmc Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis
    S Mahurkar
    Genome Research Group, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
    Gut 55:1270-5. 2006
    ..Mutations in pancreatic secretory trypsin inhibitor (SPINK1) rather than cationic trypsinogen (PRSS1) explain the disease in only 50% of TCP patients...
  75. pmc A 93 year old man with the PRSS1 R122H mutation, low SPINK1 expression, and no pancreatitis: insights into phenotypic non-penetrance
    A Khalid
    Division of Gastroenterology, Hepatology, and Nutrition, M2, C Wing, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Gut 55:728-31. 2006
    ..HP twins study suggests that modifier genes influence severity but not penetrance...
  76. doi Copy number variations in chronic pancreatitis
    J M Chen
    Institut National de la Sante et de la Recherche Medicale INSERM, U613, Brest, France
    Cytogenet Genome Res 123:102-7. 2008
    ..two loss-of-function copy number mutations (deletions) in the SPINK1 gene, which encodes pancreatic secretory trypsin inhibitor (PSTI)...
  77. pmc Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell death
    Eva Kereszturi
    Department of Molecular and Cell Biology, Boston University, Henry M Goldman School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 284:33392-9. 2009
    ..trypsin inhibitor benzamidine in the growth medium; or (2) cotransfection with the physiological trypsin inhibitor SPINK1; or (3) by mutation of the catalytic Ser(200) residue in trypsinogen...
  78. pmc A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis
    Heiko Witt
    Department of Hepatology and Gastroenterology, Charite University Hospital, Augustenburger Platz 1, 13353 Berlin, Germany
    Nat Genet 38:668-73. 2006
    ..Mutations in the genes encoding cationic trypsinogen (PRSS1) and the pancreatic secretory trypsin inhibitor (SPINK1) are associated with chronic pancreatitis...
  79. ncbi Adaptive response of the rat pancreas to dietary substrates: parallel regulation of trypsinogen and pancreatic secretory trypsin inhibitor
    R Graf
    Department of Surgery, Universitatsspital Zurich, Switzerland
    Pancreas 21:181-90. 2000
    ..g., trypsinogen) are upregulated during protein deprivation. We hypothesize that the (cationic) pancreatic secretory trypsin inhibitor (PSTI) is down-regulated after a protein-deficient diet...
  80. ncbi Increased secretion of the pancreatic secretory trypsin inhibitor (PSTI-I, monitor peptide) during development of chronic pancreatitis in the WBN/Kob rat
    R Graf
    Pancreatitis Research Laboratory, Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland
    Pancreatology 2:108-15. 2002
    Recent genetic investigations into cationic trypsinogen and pancreatic secretory trypsin inhibitor (PSTI) led to the conclusion that mutations in either gene can contribute to the development of (hereditary) chronic pancreatitis...
  81. ncbi Motion--genetic testing is useful in the diagnosis of nonhereditary pancreatic conditions: arguments for the motion
    David C Whitcomb
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pennsylvania, USA
    Can J Gastroenterol 17:47-52. 2003
    ..PRSS1) gene, the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the pancreatic secretory trypsin inhibitor (PSTI) or serine protease inhibitor, Kazal type 1 (SPINK1) gene...
  82. ncbi Serine protease inhibitor Kazal type 1 mutations and pancreatitis
    Alexander Schneider
    Department of Medicine II Gastroenterology, Hepatology and Infectious Diseases, University Hospital of Heidelberg at Mannheim, Theodor Kutzer Ufer 1 3 D 68135, Mannheim, Germany
    Gastroenterol Clin North Am 33:789-806. 2004
    In summary, SPINK1 is thought to play an important role in protecting the pancreas against excessive trypsinogen activation...
  83. doi The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families
    Christopher J Grocock
    School of Cancer Studies, University of Liverpool, UCD Building, Daulby Street, Liverpool, UK
    Gut 59:357-63. 2010
    ..To characterise the phenotypes associated with the p.A16V mutation of PRSS1...
  84. ncbi Association analyses of S(A) gene variant in essential hypertensives
    R Y Zee
    Department of Physiology, The University of Sydney, New South Wales, Australia
    Am J Hypertens 10:235-42. 1997
    ..A polymerase chain reaction technique was developed for PstI restriction fragment length polymorphism (RFLP) determination...
  85. ncbi Urinary levels of tumor-associated trypsin inhibitor (TATI) in the detection of transitional cell carcinoma of the urinary bladder
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, 75390 9110, USA
    Eur Urol 48:424-31. 2005
    To assess whether urinary levels of tumor-associated trypsin inhibitor (TATI) would aid in the detection of bladder transitional cell carcinoma (TCC); and to compare diagnostic performance of urinary TATI with that of nuclear matrix ..
  86. doi Pancreatic secretory trypsin inhibitor acts as an effective inhibitor of cysteine proteinases gingipains from Porphyromonas gingivalis
    J Bania
    Department of Food Hygiene and Consumer Protection, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
    J Periodontal Res 43:232-6. 2008
    ..The aim of this study was to investigate the susceptibility of gingipains K and R to inhibition by a pancreatic secretory trypsin inhibitor.
  87. ncbi Comparison of the prognostic value of a panel of tissue tumor markers and established clinicopathological factors in patients with gastric cancer
    Jan Patrik Wiksten
    Department of Surgery, University of Helsinki, Helsinki, Finland
    Anticancer Res 28:2279-87. 2008
    ..The studied markers were chosen to represent different aspects of tumor biology...
  88. doi Evaluation of urine tumor-associated trypsin inhibitor, CYFRA 21-1, and urinary bladder cancer antigen for detection of high-grade bladder carcinoma
    Ioannis Gkialas
    Department of Urology, Athens General Hospital, G Gennimatas, Athens, Greece
    Urology 72:1159-63. 2008
    To assess the value of urine tumor-associated trypsin inhibitor (TATI), CYFRA 21-1, which measures cytokeratin 19 fragment, and urinary bladder carcinoma antigen (UBC) for the detection of high-grade bladder carcinoma.
  89. ncbi Tumor-associated trypsin inhibitor in induced and acquired immunodeficiency. Studies on transplanted and HIV-infected patients
    G Banfi
    Laboratorio Analisi, Istituto Scientifico S Raffaele, Milano, Italy
    Scand J Clin Lab Invest Suppl 207:55-8. 1991
    A new tumor marker, tumor-associated trypsin inhibitor (TATI), was studied in 5 patients who received successful kidney or pancreas grafts and in 30 subjects with antibodies against human immunodeficiency virus...
  90. ncbi Isolation of periplasmic nitrate reductase genes from Rhodobacter sphaeroides DSM 158: structural and functional differences among prokaryotic nitrate reductases
    F Reyes
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Cordoba, Spain
    Mol Microbiol 19:1307-18. 1996
    ..A 0.6 kb BamHI-EcoRI segment of this region was used as a probe to isolate, from the wild-type strain, a 6.8 kb PstI fragment carrying the putative genes coding for the periplasmic nitrate reductase...
  91. ncbi The genome of bacteriophage phiKZ of Pseudomonas aeruginosa
    Vadim V Mesyanzhinov
    Laboratory of Gene Technology, Katholieke Universiteit Leuven, Kardinaal Mercierlaan 92, B 3001 Leuven, Belgium
    J Mol Biol 317:1-19. 2002
    ..phiKZ DNA has no detectable sequence homology to other viruses and microorganisms, and it does not contain NotI, PstI, SacI, SmaI, XhoI, and XmaIII endonuclease restriction sites...
  92. ncbi Relationship between renal function and blood level of chromogranin A
    G Tramonti
    Dipartimento di Medicina Interna Sezione di Nefrologia, Universitaz di Pisa, Italy
    Ren Fail 23:449-57. 2001
    ..Blood CGA was determined by RIA. Plasma creatinine, beta2microglobulin (beta2m) and tumor associated trypsin inhibitor (TATI) were also determined...
  93. ncbi The bifunctional rat pancreatic secretory trypsin inhibitor/monitor peptide provides protection against premature activation of pancreatic juice
    R Graf
    Pancreatitis Research Laboratory, Department of Surgery, University Hospital, Zurich, Switzerland
    Pancreatology 3:195-206. 2003
    In the rat, two forms of the pancreatic secretory trypsin inhibitor, PSTI-I and PSTI-II, are secreted into pancreatic juice...
  94. ncbi Analysis of CYP2E1 polymorphism for the determination of genetic susceptibility to gastric cancer in Koreans
    Geun Tae Park
    Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea
    J Gastroenterol Hepatol 18:1257-63. 2003
    ..The present study was undertaken to reveal the association between the polymorphism of CYP2E1 (CYP2E1/PstI and CYP2E1/DraI) with genetic susceptibility to gastric cancer development in Koreans.
  95. ncbi Mitochondrial DNA polymorphism in Chinese
    M S Yu
    Institute of Genetics, Fudan University, Shanghai
    Sci Sin B 31:860-72. 1988
    ..patterns (morphs) were observed with the enzyme ApaI, BamHI, EcoRI, HindIII, HinfI, HhaI, HapII, KpnI, Mbol, PstI, PvuII, SacI, ScaL and XhoI...
  96. ncbi Structural analysis of chloroplast DNA in Prunus (Rosaceae): evolution, genetic diversity and unequal mutations
    H Katayama
    Food Resources Education and Research Center, Kobe University, 675 2103 Hyogo, Japan
    Theor Appl Genet 111:1430-9. 2005
    ..covered the entire sequence of the peach cpDNA were digested by restriction enzymes (SalI, XhoI, BamHI, SacI, and PstI) used singly or in combination. The molecular size of peach cpDNA was estimated to be about 152 kb...
  97. ncbi The comparative molecular study between Bombycidae and Saturniidae based on mtDNA RFLP and cytochrome oxidase I gene sequences: implication for molecular evolution
    J S Hwang
    National Sericulture and Entomology Research, Suwon, Korea
    Z Naturforsch C 54:587-94. 1999
    ..Of the fourteen different restriction endonucleases used, BamHI, HindIII, PstI, EcoRI and XbaI showed RFLP. Among these, only HindIII showed RFLP between B. mori and B. mandarina...
  98. ncbi Identification and preliminary characterization of PCNA gene in the marine phytoplankton Dunaliella tertiolecta and Isochrysis galbana
    S Lin
    Marine Science Research Center, State University of New York, Stony Brook 11794, USA
    Mol Mar Biol Biotechnol 7:62-71. 1998
    ..Southern blot hybridization using a PstI fragment of rat PCNA gene (pCR-1) as a probe showed that there is apparently a single copy of this gene per haploid ..
  99. ncbi A gene involved in quinate metabolism is specific to one DNA homology group of Xanthomonas campestris
    Y A Lee
    Department of Biology, Fu Jen Catholic University, Taipei, Taiwan, Republic of China
    J Appl Microbiol 87:649-58. 1999
    ..A 0.7 kb SalI-PstI fragment internal to qumA was used as a probe to hybridize against total genomic DNA from 43 pathovars of X...
  100. pmc Complete nucleotide sequence of ubiquitous plasmid pEA29 from Erwinia amylovora strain Ea88: gene organization and intraspecies variation
    G C McGhee
    Department of Botany and Plant Pathology, Michigan State University, East Lansing, Michigan 48824 1312, USA
    Appl Environ Microbiol 66:4897-907. 2000
    ..b>PstI and KpnI restriction patterns for pEA29 isolated from tree fruit strains of E...
  101. ncbi Differentially expressed genes associated with hepatitis B virus HBx and MHBs protein function in hepatocellular carcinoma
    Dae Ghon Kim
    Division of GI and Hepatology, Department of Internal Medicine, Chonbuk National University Medical School and Hospital, Jeonbuk, Republic of Korea
    Methods Mol Biol 317:141-55. 2006
    ..genes in HCC tissue negative for HBx and MHBs-expression were preferentially expressed including pancreatic secretory trypsin inhibitor (PSTI), H19, guanidine nucleotide-binding protein alpha-1 subunit (GNAZ), carbamyl phosphate ..

Research Grants20

  1. Role of Pancreatic Trypsin Inhibitors in Pancreatic
    Rodger A Liddle; Fiscal Year: 2010
    ..With the recent identification of genetic mutations in the trypsinogen and pancreatic secretory trypsin inhibitor (PSTI) genes and their associations with hereditary and familial pancreatitis, respectively, it ..
  2. Andrew S Levey; Fiscal Year: 2014
    ..weight serum proteins: [unreadable]-trace protein (BTP), [unreadable]-2 microglobulin (B2M), and tumor associated trypsin inhibitor (TATI);and 1 metabolite: 2-([unreadable]-mannopyranosyl)-L-tryptophan (MPT, also known as Tryp-Man), ..
  3. NAPS2 Continuation Genome Wide Association Study of Pancreatitis
    DAVID CLEMENT WHITCOMB; Fiscal Year: 2011
    ..We demonstrated strong epistasis between CFTR and serine protease inhibitor Kazal type 1 (SPINK1) variants as a model of complex traits...
  4. Genetic Epidemiology of Young-Onset Pancreatic Cancer
    Robert R McWilliams; Fiscal Year: 2010
    ..Frequency of mutations in BRCA2, CDKN2A (Familial Melanoma), Fanconi Anemia Genes (FANCC and FANCG), CFTR, SPINK1, PRSS1, and polymorphisms of several DNA repair genes will be determined among 500 young-onset cases versus 1000 ..
  5. CARLOS TORRES MORAES; Fiscal Year: 2016
    ..will use a novel mouse developed in our laboratory in which a mitochondria targeted restriction endonuclease (Mito-PstI) is expressed in a tissue-specific and inducible fashion...
  6. Evette S Radisky; Fiscal Year: 2014
    ..that, for a small molecularly-defined subset of ovarian cancer patients, the secreted protein protease inhibitor SPINK1 may represent a key oncogenic driver of tumor proliferation, invasion, and chemoresistance, and that SPINK1 may ..
  7. Optical Encoding Technology for Viral Screening Panels
    ROBERT HAUSHALTER; Fiscal Year: 2009
    ..b>PSTI) will formulate a Parallume-encoded bead set containing 15 optical codes which will be used in a direct comparison ..
  8. 14th Internatinal Symposium on Inherited Diseases
    David Whitcomb; Fiscal Year: 2004
    ..Within the last few years the importance of several genetic factors has emerged, especially mutations in CFTR, the SPINK1 gene and others...
  9. NAPS2 Continuation - Genome-Wide Association Study of Pancreatitis
    David C Whitcomb; Fiscal Year: 2010
    ..Knowledge of the genetic basis of pancreatitis will lead to new treatments, and help remove the stigma that chronic pancreatitis is only a disease of drunkards. ..
  10. MOLECULAR GENETICS OF HEREDITARY PANCREATITIS
    David Whitcomb; Fiscal Year: 2008
    ..The HP and familial pancreatitis studies are especially important because of the statistical power of family studies and the ability to detect modifier genes in a uniform background of susceptibility factors. ..
  11. The Cystic Fibrosis Gene and Chronic Pancreatitis
    Jonathan Cohn; Fiscal Year: 2009
    ..g., due to polymorphism s or splice variants).Additional studies will test the prediction that the N34S PSTI mutation independently increases ICP risk in individuals with CFTR mutations...
  12. MOLECULAR BASIS OF SECRETORY DIARRHEA
    Jonathan Cohn; Fiscal Year: 2003
    ..Given the pivotal role of CFTR in the pathogenesis of diarrhea and CF this project has excellent prospects of leading to information of practical benefit in the treatment of these conditions. ..
  13. HIGHLY MULTIPLEXED GENOTYPING PLATFORM
    Steven Miller; Fiscal Year: 2005
    ..b>PSTI). They have demonstrated that it is possible to resolve >300 individual ratios from a two-color RUP system...
  14. Role of trypsinogen sulfation in alcoholic pancreatitis
    Miklos Sahin Toth; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  15. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2007
    ..Accomplishing these aims will fill significant gaps in the understanding of chronic pancreatitis and this new knowledge may help identify effective treatment approaches to this disease. [unreadable] [unreadable]..
  16. Pro & Anti-Inflammatory Cytokines in Colorectal Cancer
    GLORIA YF HO; Fiscal Year: 2010
    ..These high-risk individuals may benefit from prophylactic NSAIDS for prevention of colorectal cancer. ..
  17. Polymorphisms of INS/IGF Signal Pathways & Female Cancer
    Gloria Ho; Fiscal Year: 2006
    ..This genetic study, in conjunction with the ongoing serological study, will provide a comprehensive examination of the role of the insulin/IGF system in tumorigenes ..
  18. Aspirin, Inflammation Markers, and Colorectal Adenoma
    Gloria Ho; Fiscal Year: 2006
    ..It may also identify target populations (e.g., those with high levels of proinflammatory cytokines) who may benefit most from chemoprevention of aspirin. ..
  19. SPONTANEOUS REGRESSION BIOMARKERS IN CERVIX DYSPLASIA
    Gloria Ho; Fiscal Year: 2003
    ..DNA typing of class II HLA alleles by PCR will be performed using blood collected at baseline. Associations between these factors and regression of CIN will be assessed by appropriate univariate and multivariate analyses. ..