SRSF9

Summary

Gene Symbol: SRSF9
Description: serine and arginine rich splicing factor 9
Alias: SFRS9, SRp30c, serine/arginine-rich splicing factor 9, SR splicing factor 9, pre-mRNA-splicing factor SRp30C, splicing factor, arginine/serine-rich 9
Species: human

Top Publications

  1. ncbi Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection
    Ute Raffetseder
    Division of Nephrology and Clinical Immunology, University Hospital of Aachen, 52057 Aachen, Germany
    J Biol Chem 278:18241-8. 2003
  2. ncbi Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils
    Qing Xu
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, Denver, Colorado 80206, USA
    J Biol Chem 278:27112-8. 2003
  3. ncbi A key role for stress-induced satellite III transcripts in the relocalization of splicing factors into nuclear stress granules
    Alexandra Metz
    INSERM U309, Institut Albert Bonniot, Domaine de la Merci, 38706 La Tronche Cedex, France
    J Cell Sci 117:4551-8. 2004
  4. ncbi A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways
    Mridul Mukherji
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 45:15529-40. 2006
  5. ncbi [Dissecting molecular mechanism of spinocerebellar ataxia type 31]
    Kinya Ishikawa
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University
    Rinsho Shinkeigaku 51:1122-4. 2011
  6. pmc Identification and characterization of three members of the human SR family of pre-mRNA splicing factors
    G R Screaton
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    EMBO J 14:4336-49. 1995
  7. pmc The SR protein family
    Peter J Shepard
    Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697 4025, USA
    Genome Biol 10:242. 2009
  8. doi Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer
    Hirofumi Yoshino
    Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Biochem Biophys Res Commun 417:588-93. 2012
  9. pmc Heterogeneous Nuclear Ribonucleoprotein C Proteins Interact with the Human Papillomavirus Type 16 (HPV16) Early 3'-Untranslated Region and Alleviate Suppression of HPV16 Late L1 mRNA Splicing
    Soniya Dhanjal
    From the Department of Laboratory Medicine, Lund University, 221 84 Lund, Sweden
    J Biol Chem 290:13354-71. 2015
  10. doi Functional association of human Ki-1/57 with pre-mRNA splicing events
    Gustavo C Bressan
    Laboratorio Nacional de Luz Sincrotron, Campinas, SP, Brasil
    FEBS J 276:3770-83. 2009

Scientific Experts

  • M Mihm
  • Hiromasa Funato
  • Ankur Jain
  • D J Elliott
  • Kinya Ishikawa
  • Nozomu Sato
  • Gustavo C Bressan
  • Stefan Schwartz
  • Beatrice Orru
  • Stefan Stamm
  • Takeshi Amino
  • Hidehiro Mizusawa
  • Philippe Cloutier
  • Tatyana Novoyatleva
  • Soniya Dhanjal
  • Yan Chun Guan
  • Benoit Chabot
  • Aamira Tariq
  • Yu Fu
  • Cecilia Johansson
  • Yingzi Wang
  • Hirofumi Yoshino
  • Fergus Ryan
  • Junning Wang
  • Monika Somberg
  • Yusuke Niimi
  • John H Fingert
  • O Stoss
  • Bingnan Han
  • Dario O Passos
  • Peter J Shepard
  • Jörg Kobarg
  • Marcelo D Gomes
  • Eduardo C Moraes
  • Adriana O Manfiolli
  • Toshio Watanuki
  • Lulzim Shkreta
  • Johanne Toutant
  • Caroline Paradis
  • Jin Zhu
  • Natalya Benderska
  • Mridul Mukherji
  • Eonyoung Park
  • Christian L Lorson
  • Robert Lafyatis
  • Athena Andreadis
  • Oliver Stoss
  • S Stamm
  • Shinichi Kondo
  • Alexandra Metz
  • Qing Xu
  • Ute Raffetseder
  • Jacob Glahder
  • Mei Yun Fang
  • Liang liang Ma
  • Ann Kristin Mossberg
  • Lei Jiang
  • Xiang Nan Sun
  • Naoko Kajitani
  • Dong Xia Qu
  • Jing Liu
  • Dan Dan Yu
  • Philip J Young
  • Joy Irobi
  • Martin J Simard
  • Wojciech Garncarz
  • Wei Wu
  • Oliver Pusch
  • Michael F Jantsch
  • Ying Wang
  • Zhen Shi
  • Binlu Huang
  • Cornelia Handl
  • Jiayu Han
  • Jieqiong Huangfu
  • Ales Balik
  • Takeshi Chiyomaru
  • Masayuki Nakagawa
  • Naohiko Seki
  • Takashi Yamane
  • Tokushi Tachiwada
  • Shuichi Tatarano
  • Takenari Gotannda
  • Nijiro Nohata
  • Hideo Hidaka
  • M Denegri
  • Ciaran Cunniffe
  • Hideki Enokida
  • Takeshi Yamasaki
  • Joanna Fay

Detail Information

Publications44

  1. ncbi Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection
    Ute Raffetseder
    Division of Nephrology and Clinical Immunology, University Hospital of Aachen, 52057 Aachen, Germany
    J Biol Chem 278:18241-8. 2003
    ..Here, we identify the arginine/serine-rich SRp30c protein as an interacting protein of YB-1 by performing a two-hybrid screen against a human mesangial cell cDNA ..
  2. ncbi Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils
    Qing Xu
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, Denver, Colorado 80206, USA
    J Biol Chem 278:27112-8. 2003
    ..The predominant alternative splicing factor in neutrophils is SRp30c, which is one of several highly conserved serine-arginine-rich (SR) proteins that are involved in both ..
  3. ncbi A key role for stress-induced satellite III transcripts in the relocalization of splicing factors into nuclear stress granules
    Alexandra Metz
    INSERM U309, Institut Albert Bonniot, Domaine de la Merci, 38706 La Tronche Cedex, France
    J Cell Sci 117:4551-8. 2004
    ..We show that the recruitment of the two serine/arginine-rich (SR) proteins SF2/ASF and SRp30c requires the presence of stress-induced satellite III transcripts...
  4. ncbi A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways
    Mridul Mukherji
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 45:15529-40. 2006
    ..Selective depletion of some of these proteins, including RNA binding proteins SRRM2, SFRS1, SFRS9, and SFRS10, by siRNAs reduced the rate of migration of ErbB2-overexpressing ovarian cancer cells.
  5. ncbi [Dissecting molecular mechanism of spinocerebellar ataxia type 31]
    Kinya Ishikawa
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University
    Rinsho Shinkeigaku 51:1122-4. 2011
    ..repeats transcribed in BEAN direction form RNA aggregates ("RNA foci"), and essential splicing factors, SFRS1 and SFRS9, bind to (UGGAA)(n), the transcript of (TGGAA)(n)in vitro...
  6. pmc Identification and characterization of three members of the human SR family of pre-mRNA splicing factors
    G R Screaton
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    EMBO J 14:4336-49. 1995
    ..We have cloned a cDNA encoding a novel human SR protein designated SRp30c, which has an unusually short RS domain...
  7. pmc The SR protein family
    Peter J Shepard
    Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697 4025, USA
    Genome Biol 10:242. 2009
    ..These activities point up the importance of SR proteins during the regulation of mRNA metabolism...
  8. doi Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer
    Hirofumi Yoshino
    Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Biochem Biophys Res Commun 417:588-93. 2012
    ..In this study, we focused on splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) on the basis of our previous genome-wide gene expression analysis using miR-1-transfected BC cell lines because ..
  9. pmc Heterogeneous Nuclear Ribonucleoprotein C Proteins Interact with the Human Papillomavirus Type 16 (HPV16) Early 3'-Untranslated Region and Alleviate Suppression of HPV16 Late L1 mRNA Splicing
    Soniya Dhanjal
    From the Department of Laboratory Medicine, Lund University, 221 84 Lund, Sweden
    J Biol Chem 290:13354-71. 2015
    ..HPV16 late, 5'-splice site SD3632; produced elevated levels of RNA-binding proteins SRSF1 (ASF/SF2), SRSF9 (SRp30c), and HuR that are known to regulate HPV16 late gene expression; or were shown by a gene expression array analysis ..
  10. doi Functional association of human Ki-1/57 with pre-mRNA splicing events
    Gustavo C Bressan
    Laboratorio Nacional de Luz Sincrotron, Campinas, SP, Brasil
    FEBS J 276:3770-83. 2009
    ..assays, we verified the association of Ki-1/57 with the endogenous splicing proteins hnRNPQ and SFRS9 in HeLa cell extracts...
  11. ncbi SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1
    Philip J Young
    Arizona State University, Department of Biology, Tempe, AZ 85287 1501, USA
    Hum Mol Genet 11:577-87. 2002
    ..We now demonstrate that a second splicing factor, SRp30c, can stimulate SMN exon 7-inclusion and that this activity required the same AG-rich enhancer as hTra2 beta 1...
  12. ncbi Expression of glucocorticoid receptor isoforms and associations with serine/arginine-rich protein 30c and 40 in patients with systemic lupus erythematosus
    Yan Chun Guan
    Department of Rheumatology, The First Affiliated Hospital of Dalian Medical University, Dalian, China
    Clin Exp Rheumatol 33:225-33. 2015
    ....
  13. pmc SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis
    Yu Fu
    Protein Science Laboratory of the Ministry of Education, School of Life Sciences, Tsinghua University, Beijing, China
    EMBO Mol Med 5:737-50. 2013
    ..Overexpression of SRSF1 and SRSF9 promote β-catenin accumulation via the recruitment of β-catenin mRNA and by enhancing its translation in an mTOR-..
  14. pmc Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells
    Ankur Jain
    Department of Cell Biology and Anatomy, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107, USA
    Invest Ophthalmol Vis Sci 53:857-66. 2012
    ..mRNA splicing is mediated by spliceosomes, which include serine-arginine rich proteins (SRps). The purpose of this study was to determine whether specific SRps regulate levels of these isoforms and thereby GC response in TM cells...
  15. doi Development and validation of a novel reporter assay for human papillomavirus type 16 late gene expression
    Beatrice Orru
    Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    J Virol Methods 183:106-16. 2012
    ..of adenovirus E4orf4 protein (E4orf4), polypyrimidine tract binding protein (PTB), arginine/serine-rich SRp30c protein (SRp30c) or alternative splicing factor/splicing factor 2 (ASF/SF2) induced an increased expression of CAT ..
  16. pmc RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation
    Aamira Tariq
    Department of Chromosome Biology, Max F Perutz Laboratories, University of Vienna, Dr Bohr Gasse 1, A 1030 Vienna, Austria
    Nucleic Acids Res 41:2581-93. 2013
    ..The three proteins RPS14, SFRS9 and DDX15 interact with RNA...
  17. doi Antagonistic effects of the SRp30c protein and cryptic 5' splice sites on the alternative splicing of the apoptotic regulator Bcl-x
    Philippe Cloutier
    RNA RNP Group, Departement de Microbiologie et d Infectiologie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Biol Chem 283:21315-24. 2008
    ..b>SRp30c binds to these elements and can shift splicing to the 5' splice site of Bcl-x(L) in an ML2/AM2-dependent manner in ..
  18. pmc hnRNP I/PTB can antagonize the splicing repressor activity of SRp30c
    Caroline Paradis
    RNA RNP Group, Departement de Microbiologie et d Infectiologie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    RNA 13:1287-300. 2007
    ..We have shown previously that the 5' portion of the 38-nucleotide-long CE9 element is bound by SRp30c, and that this interaction is important for repression in vitro...
  19. doi Arginine methylation analysis of the splicing-associated SR protein SFRS9/SRP30C
    Gustavo C Bressan
    Laboratorio Nacional de Luz Sincrotron, Campinas, SP, Brasil
    Cell Mol Biol Lett 14:657-69. 2009
    The human SFRS9/SRp30c belongs to the SR family of splicing regulators. Despite evidence that members of this protein family may be targeted by arginine methylation, this has yet to be experimentally addressed...
  20. pmc Spinocerebellar ataxia type 31 is associated with "inserted" penta-nucleotide repeats containing (TGGAA)n
    Nozomu Sato
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Hum Genet 85:544-57. 2009
    ..mobility-shift assay showed that essential splicing factors, serine/arginine-rich splicing factors SFRS1 and SFRS9, bind to (UGGAA)n in vitro...
  21. pmc Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders
    John H Fingert
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA
    Mol Vis 16:596-601. 2010
    ....
  22. pmc Proteomic analysis of nuclei isolated from cancer cell lines treated with indenoisoquinoline NSC 724998, a novel topoisomerase I inhibitor
    Bingnan Han
    Developmental Therapeutics Program, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, USA
    J Proteome Res 9:4016-27. 2010
    ..12 differentially expressed proteins (ETFA, HCC1, HNRCL, KAP1, NPM, NUCL, PRDX1, PRP19, PSB6, RAE1L, RU2A, and SFRS9) were common to both cell lines...
  23. doi Serine/arginine-rich protein 30c activates human papillomavirus type 16 L1 mRNA expression via a bimodal mechanism
    Monika Somberg
    Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, Husargatan 3, Box 582, 751 23 Uppsala, Sweden
    J Gen Virol 92:2411-21. 2011
    ..These splice sites are suppressed in mitotic cells. This study showed that serine/arginine-rich protein 30c (SRp30c), also named SFRS9, activated both SD3632 and SA5639 and induced production of L1 mRNA...
  24. ncbi [Spinocerebellar ataxia type 31]
    Kinya Ishikawa
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University
    Rinsho Shinkeigaku 50:985-7. 2010
    ..We further found that splicing factors, SFRS1 and SFRS9, binds to (UGGAA)(n), the transcript of (TGGAA)(n) in vitro...
  25. ncbi Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA
    Shinichi Kondo
    Division of Structural Cellular Biology, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    Genes Cells 9:121-30. 2004
    ..b>SRp30c also enhanced the splicing of tau exon 10...
  26. pmc SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements
    O Nayler
    Max Planck Institute of Neurobiology and Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Nucleic Acids Res 26:3542-9. 1998
    ....
  27. ncbi PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes
    Y Yuan
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 273:20347-53. 1998
    ..In addition, we have found that PIR1 interacted with splicing factors 9G8 and SRp30C, possibly through an RNA intermediate during a yeast two-hybrid screen...
  28. pmc The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation
    S K Petersen-Mahrt
    Department of Medical Biochemistry and Microbiology, BMC, Uppsala University, S 751 23 Uppsala, Sweden
    EMBO J 18:1014-24. 1999
    ..Here we present evidence that p32 interacts with ASF/SF2 and SRp30c, another member of the SR protein family...
  29. ncbi Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c
    O Stoss
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Biol Chem 274:10951-62. 1999
    We report on the molecular cloning of a novel human cDNA by its interaction with the splicing factor SRp30c in a yeast two-hybrid screen...
  30. pmc A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection
    D J Elliott
    Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland
    Proc Natl Acad Sci U S A 97:5717-22. 2000
    ..Our results suggest that RBM protein is an evolutionarily conserved mammalian splicing regulator which operates as a germ cell-specific cofactor for more ubiquitously expressed pre-mRNA splicing activators...
  31. ncbi The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites
    O Stoss
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, D 82152 Martinsried, the Forschungszentrum Karlsruhe, Institut fur Genetik, Postfach 3640, D 76021 Karlsruhe, Germany
    J Biol Chem 276:8665-73. 2001
    ..various proteins involved in the regulation of alternative splicing, among them the serine/arginine-rich protein SRp30c, the splicing-associated factor YT521-B and the scaffold attachment factor B...
  32. pmc Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors
    M Denegri
    Istituto di Genetica Biochimica ed Evoluzionistica del Consiglio Nazionale delle Richerche, Pavia 27100, Italy
    Mol Biol Cell 12:3502-14. 2001
    ..With the use of the 580-725 region as bait in a two-hybrid screening, we have selected SRp30c and 9G8, two members of the SR family of splicing factors...
  33. pmc SRp30c is a repressor of 3' splice site utilization
    Martin J Simard
    Departement de Microbiologie et d Infectiologie, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Mol Cell Biol 22:4001-10. 2002
    ..This protein corresponds to SRp30c. Consistent with a role for SRp30c in the activity of CE9, recombinant SRp30c interacts specifically with CE9 and ..
  34. ncbi Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3
    Joy Irobi
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology VIB, Born Bunge Foundation BBS, University of Antwerp, Antwerpen, Belgium
    J Peripher Nerv Syst 7:87-95. 2002
    ..ubiquitous (K-ALPHA-1), tubulin alpha 3 (TUBA3), tubulin alpha 6 (TUBA6), splicing factor arginine/serine-rich 9 (SFRS9), U5 snRNP 100 kd (U5- 100K), putative chemokine receptor, GTP-binding protein (HM74), MondoA, cut (Drosophila)-..
  35. doi Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients
    Toshio Watanuki
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    J Affect Disord 110:62-9. 2008
    ....
  36. ncbi Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors
    Junning Wang
    Shriver Center at UMMS, Waltham, Massachusetts 02452, USA
    J Neurochem 88:1078-90. 2004
    ..Lastly, we identified the domains of regulators SWAP and hnRNPG, which are required for regulation of exon 10 splicing...
  37. ncbi p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1
    Oliver Stoss
    Klinikum Kassel, Pathology, Mönchebergstr 41 43, D 34125 Kassel, Germany
    Mol Cell Neurosci 27:8-21. 2004
    ..Here, we demonstrate that rSLM-1 interacts with itself, scaffold-attachment factor B, YT521-B, SAM68, rSLM-2, SRp30c, and hnRNP G. rSLM-1 regulates splice site selection in vivo via a purine-rich enhancer...
  38. ncbi Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1
    Yingzi Wang
    Shriver Center at University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
    J Biol Chem 280:14230-9. 2005
    ..this study, we investigated three regulators of exon 2 and 10 splicing: serine/arginine-rich (SR) proteins SRp55, SRp30c, and htra2beta1. The first two inhibit both exons; htra2beta1 inhibits exon 2 but activates exon 10...
  39. ncbi Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript
    Eonyoung Park
    School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    J Biol Chem 281:401-9. 2006
    ..b>SRp30c specifically binds to both ESE3 and ESE4, whereas 9G8 binds to an element in exon 3 and strongly enhances the ..
  40. ncbi Differential effects of antidepressants on dexamethasone-induced nuclear translocation and expression of glucocorticoid receptor
    Hiromasa Funato
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Brain Res 1117:125-34. 2006
    ..Antidepressants did not alter the expression of SRp30c that is associated with alternative splicing of GR transcript...
  41. pmc Bombesin attenuates pre-mRNA splicing of glucocorticoid receptor by regulating the expression of serine-arginine protein p30c (SRp30c) in prostate cancer cells
    Jin Zhu
    Department of Urology, Weill Medical College of Cornell University and New York Presbyterian Hospital, Rm E 300, Box 23, 1300 York Ave, New York, NY 10021, USA
    Biochim Biophys Acta 1773:1087-94. 2007
    ..We found that suppression of SRp30c expression by siRNA specifically antagonized bombesin's effect on glucocorticoid-mediated inhibition of PC cells, ..
  42. ncbi Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing
    Tatyana Novoyatleva
    University of Erlangen, Institute for Biochemistry, Germany
    Hum Mol Genet 17:52-70. 2008
    ..Eight other proteins, including SF2/ASF and SRp30c, contain an evolutionary conserved PP1 docking motif in the beta-4 strand of their RRMs indicating that binding to ..
  43. doi Differentiation of the bovine dominant follicle from the cohort upregulates mRNA expression for new tissue development genes
    M Mihm
    Division of Cell Sciences, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
    Reproduction 135:253-65. 2008
    ..growth arrest and DNA damage-inducible, beta; GADD45B), RNA synthesis (splicing factor, arginine/serine rich 9; SFRS9) and unknown processes associated with enhanced steroidogenesis (ovary-specific acidic protein; DQ004742) in ..