STAT3

Summary

Gene Symbol: STAT3
Description: signal transducer and activator of transcription 3
Alias: ADMIO, ADMIO1, APRF, HIES, signal transducer and activator of transcription 3, DNA-binding protein APRF, acute-phase response factor
Species: human

Top Publications

  1. ncbi Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma
    Yoshiyasu Aoki
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:1535-42. 2003
  2. pmc STATs in cancer inflammation and immunity: a leading role for STAT3
    Hua Yu
    Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
    Nat Rev Cancer 9:798-809. 2009
  3. pmc STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
    Dimitrios Iliopoulos
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 39:493-506. 2010
  4. ncbi Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    Z Zhong
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021
    Science 264:95-8. 1994
  5. pmc B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
    Danielle T Avery
    Immunology Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    J Exp Med 207:155-71. 2010
  6. pmc STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
    J Chung
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 17:6508-16. 1997
  7. pmc Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    Sizhi Paul Gao
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Invest 117:3846-56. 2007
  8. pmc STAT3 upregulates the protein expression and transcriptional activity of β-catenin in breast cancer
    Hanan Armanious
    Department of Laboratory Medicine and Pathology, Cross Cancer Institute and University of Alberta Edmonton, Alberta, Canada
    Int J Clin Exp Pathol 3:654-64. 2010
  9. pmc STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain
    Olga A Timofeeva
    Department of Oncology and Radiation Medicine, and Drug Discovery Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Proc Natl Acad Sci U S A 110:1267-72. 2013
  10. pmc Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma
    Lloyd T Lam
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 111:3701-13. 2008

Research Grants

  1. Gadiparthi N Rao; Fiscal Year: 2016
  2. Cong Yan; Fiscal Year: 2014
  3. STAT3 Structural Determinants
    Nancy C Reich; Fiscal Year: 2012
  4. Cell signaling as a leukemia biomarker
    JAMES WILLIAM JACOBBERGER; Fiscal Year: 2013
  5. Adiponectin effects on leptin signaling in hepatocellular carcinoma
    Neeraj Kumar Saxena; Fiscal Year: 2011
  6. Kevin D Cooper; Fiscal Year: 2014
  7. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
  8. Haojie Huang; Fiscal Year: 2015
  9. Robert A Anders; Fiscal Year: 2014
  10. Functional Role of IL-6 in Fetal Brain Development and Abnormal Behavior
    Elaine Hsiao; Fiscal Year: 2012

Detail Information

Publications394 found, 100 shown here

  1. ncbi Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma
    Yoshiyasu Aoki
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:1535-42. 2003
    ..Here we show that inhibition of signal transducer and activator of transcription-3 (STAT3) leads to apoptosis in PEL cells. STAT3 is constitutively phosphorylated in PEL cell lines BC-1, BCBL-1, and VG-1...
  2. pmc STATs in cancer inflammation and immunity: a leading role for STAT3
    Hua Yu
    Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
    Nat Rev Cancer 9:798-809. 2009
    ..Persistently activated STAT3 and, to some extent, STAT5 increase tumour cell proliferation, survival and invasion while suppressing anti-tumour ..
  3. pmc STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
    Dimitrios Iliopoulos
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 39:493-506. 2010
    ..b>STAT3, a transcription factor activated by IL-6, directly activates miR-21 and miR-181b-1...
  4. ncbi Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    Z Zhong
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021
    Science 264:95-8. 1994
    ..A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth ..
  5. pmc B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
    Danielle T Avery
    Immunology Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    J Exp Med 207:155-71. 2010
    ..Interleukin (IL)-21 activates STAT1 and STAT3 and has emerged as a potent regulator of B cell differentiation...
  6. pmc STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
    J Chung
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 17:6508-16. 1997
    Recent studies have indicated that serine phosphorylation regulates the activities of STAT1 and STAT3. However, the kinase(s) responsible and the role of serine phosphorylation in STAT function remain unresolved...
  7. pmc Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    Sizhi Paul Gao
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Invest 117:3846-56. 2007
    Persistently activated or tyrosine-phosphorylated STAT3 (pSTAT3) is found in 50% of lung adenocarcinomas...
  8. pmc STAT3 upregulates the protein expression and transcriptional activity of β-catenin in breast cancer
    Hanan Armanious
    Department of Laboratory Medicine and Pathology, Cross Cancer Institute and University of Alberta Edmonton, Alberta, Canada
    Int J Clin Exp Pathol 3:654-64. 2010
    ..Our analysis of the gene promoter of β-catenin revealed multiple putative STAT3 binding sites...
  9. pmc STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain
    Olga A Timofeeva
    Department of Oncology and Radiation Medicine, and Drug Discovery Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Proc Natl Acad Sci U S A 110:1267-72. 2013
    Activation of STAT3 in cancers leads to gene expression promoting cell proliferation and resistance to apoptosis, as well as tumor angiogenesis, invasion, and migration...
  10. pmc Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma
    Lloyd T Lam
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 111:3701-13. 2008
    ..Using RNA interference for STAT3, we defined a gene expression signature of IL-6 and IL-10 signaling through STAT3...
  11. pmc Stat3 activation by Src induces specific gene regulation and is required for cell transformation
    J Turkson
    H Lee Moffitt Cancer Center and Research Institute, and Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa 33612, USA
    Mol Cell Biol 18:2545-52. 1998
    ..Previous studies have demonstrated that one STAT family member, Stat3, possesses constitutively elevated tyrosine phosphorylation and DNA-binding activity in fibroblasts stably ..
  12. ncbi Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells
    Lanxi Song
    Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Insitute, University of South Florida College of Medicine Tampa, FL 33612, USA
    Oncogene 22:4150-65. 2003
    ..Here we demonstrate that multiple nonsmall cell lung cancer cell lines demonstrate constitutive Stat3 DNA-binding activity...
  13. pmc STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation
    SEAN A DIEHL
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 180:4805-15. 2008
    ..STAT activation by cytokines and their effects on B cell differentiation prompted us to investigate the effect of STAT3 activation in plasma cell differentiation...
  14. pmc Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells
    L Y W Bourguignon
    San Francisco Veterans Affairs Medical Center and Department of Medicine, University of California at San Francisco and Endocrine Unit 111N2, San Francisco, CA 94121, USA
    Oncogene 31:149-60. 2012
    ..This novel Nanog/Stat-3 signaling pathway-specific mechanism involved in miR-21 production is significant for the formation of future intervention strategies in the treatment of HA/CD44-activated HNSCC...
  15. doi STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells
    Zheng Wei
    Key Laboratory of Hepatosplenic Surgery, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
    Cell Signal 25:931-8. 2013
    The interleukin-6 (IL-6)/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway mediates cell proliferation and migration...
  16. ncbi Stat3 as an oncogene
    J F Bromberg
    Laboratory of Molecular Cell Biology, The Rockefeller University, New York, New York 10021 6399, USA
    Cell 98:295-303. 1999
    ..In many human cancers and transformed cell lines, Stat3 is persistently activated, and in cell culture, active Stat3 is either required for transformation, enhances ..
  17. doi Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway
    Matthias Brock
    Center for Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Circ Res 104:1184-91. 2009
    ..Because IL-6 signaling is mainly mediated by STAT3 (signal transducer and activator of transcription 3), the expression of STAT3 was knocked down by small interfering RNA, which abolished the IL-..
  18. pmc Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?
    Bharat B Aggarwal
    Department of Experimental Therapeutics, Cytokine Research Laboratory, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Ann N Y Acad Sci 1171:59-76. 2009
    ..Several of these small molecules are chemopreventive agents derived from plants. This review discusses the intimate relationship between STAT-3, inflammation, and cancer in more detail...
  19. doi Oct-4 is required for an antiapoptotic behavior of chemoresistant colorectal cancer cells enriched for cancer stem cells: effects associated with STAT3/Survivin
    Kunming Wen
    Department of General Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China
    Cancer Lett 333:56-65. 2013
    ..Knockdown increased apoptosis, decreased CSCs marker expression and weakened tumorigenicity in drug-resistant cell lines. In conclusion, we show that these events can be at least in part attributed to the STAT3/Survivin pathway.
  20. ncbi Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
    Guilian Niu
    Immunology Program, H Lee Moffitt Cancer Center and Research Institute, Department of Oncology, University of South Florida College of Medicine, Tampa, Florida, FL 33612, USA
    Oncogene 21:2000-8. 2002
    ..While tyrosine kinases signal through multiple pathways, signal transducer and activation of transcription 3 (Stat3) is a point of convergence for many of these and is constitutively activated with high frequency in a wide range ..
  21. doi Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer
    Jing Chen
    The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China
    Mol Cancer Ther 11:277-87. 2012
    b>STAT3 has been strongly implicated in human malignancies, and constitutive activation of STAT3 serves a crucial role in cell survival, angiogenesis, immune evasion, and inflammation...
  22. ncbi Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages
    Lynn Williams
    Kennedy Institute of Rheumatology Division, Imperial College London, ARC Building, 1 Aspenlea Road, Hammersmith, London W6 8LH, United Kingdom
    J Immunol 172:567-76. 2004
    ..Macrophage-specific STAT3-null mice have demonstrated that STAT3 plays a critical role in the suppression of LPS-induced TNF-alpha release, ..
  23. pmc Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas
    B Belinda Ding
    Departments of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 111:1515-23. 2008
    ..Here, we report that the STAT3 gene is a transcriptional target of BCL6...
  24. doi Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells
    Shuling Huang
    Department of Gastroenterology, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China
    Cancer Lett 315:198-205. 2012
    ..The underlying mechanisms of this phenomenon have not been well understood. Accumulating evidence indicates that Stat3 plays an important role in tumorigenesis of various primary cancers and cancer cell lines by upregulating cell ..
  25. ncbi Stat3 regulates genes common to both wound healing and cancer
    Daniel J Dauer
    Thoracic Oncology Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Oncogene 24:3397-408. 2005
    ..The mechanisms that link wound healing and cancer are poorly understood. We report here that Stat3, a common signaling mechanism involved in oncogenesis and tissue injury, regulates a common set of genes involved ..
  26. pmc Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis
    Nandini Sen
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:600-5. 2012
    ..Conversely, in this study, we found that VZV triggers STAT3 phosphorylation in cells infected in vitro and in human skin xenografts in SCID mice in vivo and that STAT3 ..
  27. doi MiR-21 modulates hTERT through a STAT3-dependent manner on glioblastoma cell growth
    Ying Yi Wang
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, China
    CNS Neurosci Ther 18:722-8. 2012
    ..However, the precise biological function and molecular mechanism of miR-21 in GBM remain elusive. This study is designed to explore the mechanism of miR-21 involved in the control of GBM cell growth...
  28. pmc Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation
    Kouji Izumi
    George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA
    EMBO Mol Med 5:1383-401. 2013
    ..dissection revealed that targeting PCa AR with siRNA promoted PCa cell migration/invasion via CCL2-dependent STAT3 activation and epithelial-mesenchymal transition (EMT) pathways...
  29. pmc The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation
    Daniel J Gough
    New York University Langone School of Medicine, New York, NY, United States of America
    PLoS ONE 8:e83395. 2013
    Activating mutations in the RasGTPases are the most common oncogenic lesions in human cancer. Similarly, elevated STAT3 expression and/or phosphorylation are observed in the majority of human cancers...
  30. pmc Epithelial to mesenchymal transition promotes breast cancer progression via a fibronectin-dependent STAT3 signaling pathway
    Nikolas Balanis
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 288:17954-67. 2013
    ..cancer (BC) model, we find that in addition to EGF, adhesion to fibronectin (FN) activates signal transducer and activator of transcription 3 (STAT3) through EGFR-dependent and -independent mechanisms...
  31. pmc Signal transducer and activator of transcription (STAT)-3 regulates microRNA gene expression in chronic lymphocytic leukemia cells
    Uri Rozovski
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer 12:50. 2013
    ..deregulated in chronic lymphocytic leukemia (CLL) and signal transducer and activator of transcription (STAT)-3 is constitutively activated in CLL, we sought to determine whether STAT3 affects the transcription of miR genes in CLL cells.
  32. ncbi Constitutive activation of STAT transcription factors in acute myelogenous leukemia
    K Spiekermann
    Department of Medicine III, Grosshadern, Germany
    Eur J Haematol 67:63-71. 2001
    ..patterns of STAT activation were found: (I) activation of only STAT1, (II) activation of STAT1 in combination with STAT3, and (III) activation of STAT1, 3 and 5...
  33. ncbi Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis
    Marisa Dolled-Filhart
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Clin Cancer Res 9:594-600. 2003
    ..a high frequency of tumors contain constitutively activated signal transducers and activators of transcription 3 (Stat3), its relationship to breast cancer and patient survival has not been determined in a large retrospective study of ..
  34. pmc Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression
    Emily C Brantley
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Clin Cancer Res 14:4694-704. 2008
    ..The objective of this study was to examine the expression of STAT-3 and its negative regulator, PIAS3, in human tissue samples from control and GBM brains...
  35. pmc Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells
    Cecilia Proietti
    Instituto de Biología y Medicina Experimental IBYME, CONICET, Buenos Aires 1428, Argentina
    Mol Cell Biol 25:4826-40. 2005
    ..In the present study, we explored the capacity of progestins to modulate Stat3 transcriptional activation in an experimental model of hormonal carcinogenesis in which the synthetic progestin ..
  36. ncbi Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma
    Yajun Han
    Department of Laboratory Medicine and Pathology, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2
    Blood 108:2796-803. 2006
    ..24 hours of transfection, pJAK3 and pSTAT3 were decreased, and these changes correlated with down-regulation of STAT3 downstream targets including cyclin D3, mcl-1, and bcl-2...
  37. pmc Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer
    Marjan Berishaj
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 USA
    Breast Cancer Res 9:R32. 2007
    b>Signal transducer and activator of transcription 3 (Stat3) is constitutively tyrosine-phosphorylated in approximately 50% of primary breast carcinomas...
  38. pmc Green tea catechins inhibit angiogenesis through suppression of STAT3 activation
    Hoyee Leong
    The Ben May Department for Cancer Research, The University of Chicago, GCIS W325D, 929 East 57th Street, Chicago, IL 60637, USA
    Breast Cancer Res Treat 117:505-15. 2009
    ..IFN-gamma)-induced gene transcription via IFN-gamma-activating sequence (GAS) elements and downstream STAT3 activation by inhibiting STAT1 and STAT3 dimerization in MDA-MB231 cells...
  39. doi The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3
    Michael Vogt
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrasse 30, Aachen 52074, Germany
    J Cell Sci 124:900-9. 2011
    b>STAT3 is an important transcription factor involved in immunity and cancer. In response to cytokine stimulation, STAT3 becomes phosphorylated on a single tyrosine residue...
  40. ncbi Association of the chaperone glucose-regulated protein 58 (GRP58/ER-60/ERp57) with Stat3 in cytosol and plasma membrane complexes
    Gary G Guo
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    J Interferon Cytokine Res 22:555-63. 2002
    ..proteins in the S100 cytosol fraction of human hepatoma Hep3B cells that was differentially coshifted by anti-Stat3 antibody in an antibody-subtracted differential protein display assay...
  41. pmc Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness
    Nuria de la Iglesia
    Department of Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5870-8. 2008
    ..Genetic studies suggest that the transcription factor signal transducers and activators of transcription 3 (STAT3) harbors a PTEN-regulated tumor suppressive function in mouse astrocytes...
  42. ncbi Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
    C Lutticken
    Institute for Biochemistry, RWTH Aachen, Germany
    Science 263:89-92. 1994
    ..Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenically related to the p91 subunit of the interferon-stimulated gene factor-3 alpha (ISGF-3 alpha)..
  43. ncbi Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling
    Sachiko Kamakura
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 6:547-54. 2004
    ..Here we show that STAT3 is activated in the presence of active Notch, as well as the Notch effectors Hes1 and Hes5...
  44. pmc Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells
    Lilly Y W Bourguignon
    Department of Medicine, University of California, San Francisco, and Endocrine Unit, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 283:17635-51. 2008
    ....
  45. pmc JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling
    Lanxi Song
    Thoracic Oncology and Experimental Therapeutics Programs H Lee Moffitt Cancer Center and Research Institute MRC3 East, Room 3056F, 12902 Magnolia Drive Tampa, Florida 33612 9497, USA
    Mol Cancer Ther 10:481-94. 2011
    ..cell lines including those with activating mutations in the EGFR and examined upstream kinases responsible for STAT3 phosphorylation and activation using small molecules, antibodies, and RNA interference...
  46. ncbi ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases
    M A Olayioye
    Friedrich Miescher Institute, P O Box 2543, CH 4002 Basel, Switzerland
    J Biol Chem 274:17209-18. 1999
    ..In A431 cells, Stat1, Stat3, and Stat5, were constitutively complexed with ErbB1 and rapidly phosphorylated on tyrosine in response to EGF...
  47. pmc The Current STATus of lymphocyte signaling: new roles for old players
    Adewole S Adamson
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    Curr Opin Immunol 21:161-6. 2009
    ..Focusing on how STATs work in concert with other transcription factors will hopefully provide a better mechanistic understanding of the pathogenesis of various autoimmune diseases...
  48. doi Reciprocal effects of STAT5 and STAT3 in breast cancer
    Sarah R Walker
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cancer Res 7:966-76. 2009
    ..Two related transcription factors, signal transducer and activator of transcription (STAT) 5 and STAT3, play important and distinct roles in mammary development and both can be activated in breast cancer...
  49. pmc Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma
    S Takemoto
    Department of Obstetrics and Gynecology, Kurume University School of Medicine, Fukuoka, Japan
    Br J Cancer 101:967-72. 2009
    b>Stat3 is a member of the Janus-activated kinase/STAT signalling pathway. It normally resides in the cytoplasm and can be activated through phosphorylation...
  50. doi Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin
    Ji Hye Seo
    Myunggok Medical Research Institute, College of Medicine, Konyang Univeristy, Daejeon 302 718, Republic of Korea
    Cancer Lett 288:50-6. 2010
    ..In this report, we determined the role of signal transducers and activators of transcription 3 (STAT3) and the effect of a chemopreventive agent, curcumin, on LPA-induced ovarian cancer cell motility...
  51. pmc Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells
    Yan Liu
    Department of Pediatrics, Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, The Ohio State University, Columbus, Ohio 43205, USA
    J Biol Chem 285:27429-39. 2010
    ..However, IL-6 also activates STAT3 in many types of human cancer...
  52. ncbi Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution
    Bharat B Aggarwal
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Ann N Y Acad Sci 1091:151-69. 2006
    ..Signal-transducer-and-activator-of-transcription-3 (STAT3), a member of a family of six different transcription factors, is closely linked with tumorigenesis...
  53. pmc Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome
    Ellen D Renner
    Department of Pediatrics, University of Washington School of Medicine and Children s Hospital and Regional Medical Center, Seattle, Wash 98101 1304, USA
    J Allergy Clin Immunol 122:181-7. 2008
    ..Recently it was shown that heterozygous signal transducer and activator of transcription 3 (STAT3) mutations cause autosomal-dominant HIES.
  54. ncbi Serine phosphorylation and negative regulation of Stat3 by JNK
    C P Lim
    Signal Transduction Laboratory, Institute of Molecular and Cell Biology, National University of Singapore, Singapore 117609
    J Biol Chem 274:31055-61. 1999
    ..Recently, serine phosphorylation of Stat3 on Ser-727 by ERK has been identified in response to epidermal growth factor (EGF)...
  55. ncbi Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
    Jiazhi Sun
    Department of Interdisciplinary Oncology, Drug Discovery and Molecular Oncology Programs, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, MRC DRDIS, Tampa, FL 33612 9497, USA
    Oncogene 24:3236-45. 2005
    Constitutive activation of the JAK/STAT3 pathway is a major contributor to oncogenesis...
  56. pmc Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction
    Svetlana A Tsareva
    Institute of Biochemistry I, Friedrich Schiller University Jena Medical School, Jena, Germany
    Neoplasia 9:279-91. 2007
    b>Signal transducer and activator of transcription 3 (STAT3) is aberrantly activated in colorectal carcinomas (CRCs). Here, we define the relationship between STAT3 function and the malignant properties of colon carcinoma cells...
  57. pmc S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling
    Yi Xie
    Laboratories of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Endocrinology 150:1122-31. 2009
    ..particularly susceptible to redox regulation, we hypothesized that oxidative modification of cysteine residues of STAT3 by S-glutathionylation may occur...
  58. doi Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population
    Lynnette R Ferguson
    Discipline of Nutrition, FM and HS, The University of Auckland, Auckland, New Zealand Nutrigenomics New Zealand, New Zealand
    Mutat Res 690:108-15. 2010
    ..Two members of that pathway, STAT3 and JAK2, enhanced the risk of Crohn's disease (CD) in recent genome-wide association studies...
  59. pmc STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells
    Inbal Hazan-Halevy
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 115:2852-63. 2010
    ..In CLL, however, STAT3 is constitutively phosphorylated on serine 727, not tyrosine 705, residues...
  60. pmc Rac1 mediates STAT3 activation by autocrine IL-6
    T R Faruqi
    Department of Pathology, State University of New York, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 98:9014-9. 2001
    ..In this report constitutively active Rac1 (Rac V12) is shown to stimulate the activation of STAT3, a member of the family of signal transducers and activators of transcription (STATs)...
  61. ncbi Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system
    Virote Sriuranpong
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, 20892 4330, USA
    Cancer Res 63:2948-56. 2003
    ..is often associated with the constitutive activation of signal-transducer-and-activator-of-transcription-3 (STAT3), which is believed to result from the persistent stimulation of EGF receptors that are highly expressed in ..
  62. pmc Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo
    Dana M Bronte-Tinkew
    Department of Pediatrics and Physiology, University of Toronto, Toronto, Canada
    Cancer Res 69:632-9. 2009
    ..Recent evidence indicates that aberrant activation of the signal transducers and activators of transcription 3 (STAT3) signaling pathway may play a role in gastric carcinogenesis. Therefore, we hypothesized that H...
  63. pmc Activation of the signal transducer and activator of transcription 3 pathway up-regulates estrogen receptor-beta expression in lung adenocarcinoma cells
    Hao Chen Wang
    Institute of Basic Medical Sciences, National Cheng Kung University, Medical College, Tainan, Taiwan, Republic of China
    Mol Endocrinol 25:1145-58. 2011
    ..We have found that signal transducer and activator of transcription 3 (Stat3) activation up-regulates ERβ expression in PC14PE6/AS2 lung cancer cells in a ..
  64. pmc STAT3 mediates resistance to MEK inhibitor through microRNA miR-17
    Bingbing Dai
    Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 71:3658-68. 2011
    ..In particular, ingenuity pathway analysis revealed that activation of the STAT3 pathway was associated with MEK inhibitor resistance...
  65. doi Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis
    Amir Sonnenblick
    Sharett Institute of Oncology, Hadassah Hebrew University Medical Center, Ein Kerem, POB 12000, Jerusalem 91120, Israel
    Clin Transl Oncol 14:232-6. 2012
    ..b>Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signalling pathways...
  66. doi EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis
    Tobias Ettl
    Department of Oral and Maxillofacial Surgery, University of Regensburg, Franz Josef Strauβ Allee 11, 93053 Regensburg, Germany
    Hum Pathol 43:921-31. 2012
    ..b>STAT3 and the apoptosis inhibitor survivin represent distinct oncogenes in various human neoplasms...
  67. pmc Functional regulatory role of STAT3 in HPV16-mediated cervical carcinogenesis
    Shirish Shukla
    Division of Molecular Oncology, Institute of Cytology and Preventive Oncology, Noida, Uttar Pradesh, India
    PLoS ONE 8:e67849. 2013
    b>Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor constitutively active and aberrantly expressed in cervical cancer...
  68. doi Abrogation of constitutive Stat3 activity circumvents cisplatin resistant ovarian cancer
    Teng Ji
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    Cancer Lett 341:231-9. 2013
    The aim of the present study was to investigate the role of Stat3 in cisplatin resistant ovarian cancer. It was first demonstrated that higher activated Stat3 was detected in cisplatin-resistant ovarian cancer cell lines...
  69. doi The modulation of microRNAs by type I IFN through the activation of signal transducers and activators of transcription 3 in human glioma
    Masasuke Ohno
    Department of Neurosurgery, Aichi Cancer Center Research Institute, Nagoya 466 8550, Japan
    Mol Cancer Res 7:2022-30. 2009
    ..the IFN-beta-mediated suppression of miR-21; the addition of signal transducers and activators of transcription 3 (STAT3)-expressing vectors induced the IFN-beta-mediated suppression of miR-21, whereas STAT3-inhibiting agents inhibited ..
  70. ncbi Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation
    J J Schuringa
    Department of Genetics, Biological Center, Kerklaan 30, 9751 NN Haren, The Netherlands
    J Biol Chem 276:27709-15. 2001
    Activation of signal transducer and activator of transcription 3 (STAT3) by interleukin-6 (IL-6) involves phosphorylation of Tyr-705 and Ser-727, both of which are critical for STAT3 transactivation...
  71. ncbi Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells
    Adina Vultur
    Department of Microbiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Oncogene 23:2600-16. 2004
    b>Stat3 (signal transducer and activator of transcription-3) activity is required for transformation by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to induce neoplastic transformation...
  72. ncbi STAT3 ser727 phosphorylation and its association with negative estrogen receptor status in breast infiltrating ductal carcinoma
    Yao Tsung Yeh
    Institute of Medicine, Kaohsiung Medical University, Taiwan, Republic of China
    Int J Cancer 118:2943-7. 2006
    Although it is known that STAT3 transcriptional activity is modulated by phosphorylation at serine residue 727, the role of STAT3 serine phosphorylation in breast cancer remains mostly unexplored...
  73. ncbi Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation
    Hao H Ho
    Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, New York, New York 10021, USA
    J Biol Chem 281:14111-8. 2006
    ..In myeloid cells IFNalpha/beta activates signal transducers and activators of transcription STAT1, STAT2, and STAT3. STAT1 and STAT2 mediate the antiviral and inflammatory effects of IFNalpha/beta, but the function of IFNalpha/..
  74. ncbi REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells
    Akira Sekikawa
    Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine 880 Kitakobayshi, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Carcinogenesis 29:76-83. 2008
    b>Signal transducer and activator of transcription 3 (STAT3) signaling plays roles in inflammation-associated carcinogenesis...
  75. pmc Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
    Cindy S Ma
    Immunology and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst 2010, Australia
    J Exp Med 205:1551-7. 2008
    ..Recent investigations have identified mutations in STAT3 in the majority of HIES patients studied...
  76. pmc Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas
    Camilla Pilati
    Génomique fonctionnelle des tumeurs solides, Institut National de la Sante et de la Recherche Medicale INSERM, U674, Paris, F 75010, France
    J Exp Med 208:1359-66. 2011
    ..Here, we report that 12% of IHCA subsets lacking IL6ST mutations harbor somatic signal transducer and activator of transcription 3 (STAT3) mutations (6/49)...
  77. doi STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer
    B Jiang
    Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China
    Genet Mol Res 10:1856-65. 2011
    Signal transducer and activator of transcription protein 3 (STAT3) has been implicated in cancer development and is recognized as a type of oncogene...
  78. pmc Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy
    M Gupta
    Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 26:1356-64. 2012
    ..ABC cell lines have constitutive activation of STAT3; however, the mechanisms regulating STAT3 signaling in lymphoma are unknown...
  79. doi Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets
    Caroline Gest
    Laboratoire M E R C I EA 3829, Faculte de Medecine et de Pharmacie, Universite de Rouen, Rouen, France
    Cancer Lett 317:207-17. 2012
    ..Among 10 agents tested for their ability to decrease cancer cell aggressivity using these two models, inhibitors of Stat3, IGF-IR and Rho GTPase were found to be the most promising.
  80. doi JAK2 and STAT3 polymorphisms in a Han Chinese population with Behçet's disease
    Ke Hu
    First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, People s Republic of China
    Invest Ophthalmol Vis Sci 53:538-41. 2012
    Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) polymorphisms have been demonstrated as a common risk factor for a number of autoimmune diseases...
  81. doi Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease
    N Polgar
    Department of Medical Genetics, University of Pecs, Pecs, Hungary
    Int J Immunogenet 39:247-52. 2012
    ..Components of the interleukin-23 signalling pathway, such as IL23R, JAK2 and STAT3, have been implicated in both diseases...
  82. pmc Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation
    Heehyoung Lee
    Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 109:7765-9. 2012
    ..Here, we report that lysine acetylation of the oncogenic transcription factor STAT3 is elevated in tumors...
  83. pmc Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP
    Mamta Gupta
    Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Blood 120:4400-6. 2012
    b>STAT3 regulates cell growth by up-regulating downstream targets, such as Myc...
  84. pmc New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain
    Laure Dumoutier
    Ludwig Institute for Cancer Research, B 1200 Brussels
    J Biol Chem 284:26377-84. 2009
    ..of the interleukin-22 receptor (IL-22R) recruits in a tyrosine-independent manner the coiled-coil domain of STAT3. Mutation of all IL-22R cytoplasmic tyrosines did not abolish activation of STAT3, in contrast to that of STAT1 ..
  85. pmc Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species
    Karol Szczepanek
    Department of Biochemistry and Molecular Biology, Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 286:29610-20. 2011
    Expression of the STAT3 transcription factor in the heart is cardioprotective and decreases the levels of reactive oxygen species...
  86. doi Glucocorticoids enhance Th17/Th1 imbalance and signal transducer and activator of transcription 3 expression in systemic lupus erythematosus patients
    Catuxa Prado
    Department of Functional Biology, Immunology Area, Faculty of Medicine, University of Oviedo, c Julian Claveria s n, Oviedo, Asturias, Spain
    Rheumatology (Oxford) 50:1794-801. 2011
    ..To investigate the relative amounts of Th17 and Th1 cells present in SLE patients and the possible effects of treatments or disease features on these populations...
  87. pmc IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma
    Fang Ming Gu
    Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, P R China
    Mol Cancer 10:150. 2011
    ..However, their relevance in cancer biology remains controversial. This study aimed to clarify the biological action of IL-17 on hepatocellular carcinoma (HCC)...
  88. ncbi Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction
    A Kaptein
    Laboratoires Glaxo Wellcome, Centre de Recherche, ZA de Courtaboeuf, France
    J Biol Chem 271:5961-4. 1996
    Interleukin-6 (IL-6) induces tyrosine phosphorylation and activation of the latent transcription factor Stat3 in HepG2 cells...
  89. ncbi Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor
    Huang Shao
    Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 63:3923-30. 2003
    The oncogene signal transducer and activator of transcription 3 (Stat3) is constitutively activated in a wide variety of human cancers, including squamous cell carcinoma of the head and neck...
  90. ncbi STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets
    A V Ivanova
    Basic Research Program, SAIC Frederick Inc, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    J Mol Biol 340:641-53. 2004
    ..for STRA13-interacting proteins with oncogenic potential by the yeast two-hybrid screening, we identified STAT3 beta as a STRA13-binding partner...
  91. pmc Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells
    In Ohk Lee
    Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seodaemunku Shinchondong 134, Seoul 120 752, Korea
    J Biol Chem 285:16042-50. 2010
    ..relation to its tyrosine phosphorylation status on the gp130-mediated signal switch between the SHP2/ERK and JAK/STAT3 pathways. We showed that in the presence of CagA, SHP2 was recruited to gp130...
  92. doi Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells
    Romain Bedel
    INSERM Institut National de la Santé et de la Recherche Médicale UMR 645, Besancon, France
    Cancer Res 71:1615-26. 2011
    ..b>STAT3 plays a pivotal role both in oncogenic functions and in immunosuppression...
  93. pmc Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer
    Rachel Haviland
    Molecular Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
    PLoS ONE 6:e24923. 2011
    Cytokine and growth factor signaling pathways involving STAT3 are frequently constitutively activated in many human primary tumors, and are known for the transcriptional role they play in controlling cell growth and cell cycle ..
  94. doi Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation
    Kiyomi Takaishi
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Cancer Sci 101:2128-36. 2010
    ..This study focused on the activation of signal transducer and activator of transcription 3 (Stat3) which is a critical signal transduction molecule at a point of convergence for ..
  95. pmc Activation and association of Stat3 with Src in v-Src-transformed cell lines
    X Cao
    Signal Transduction Laboratory, Institute of Molecular and Cell Biology, National University of Singapore
    Mol Cell Biol 16:1595-603. 1996
    ..New members of the STAT gene family are identified. Among them, Stat3 has 52...
  96. pmc The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6
    T Zhang
    Institute of Molecular and Cell Biology, Singapore 117609, Singapore
    Mol Cell Biol 20:7132-9. 2000
    ..of the N-domain and each of the alpha-helices and mutagenesis of conserved residues in the coiled-coil region of Stat3. Our results indicate that the coiled-coil domain is essential for Stat3 recruitment to the receptor and the ..
  97. ncbi Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway
    Michael Yeh
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 279:30175-81. 2004
    ..Furthermore, treatment of HAEC with Ox-PAPC and its component PEIPC induced the activation of STAT3 by phosphorylating Tyr705, a feature of STAT3 activation. STAT3 is a known downstream effector of c-src...
  98. ncbi Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas
    Huamin Wang
    Department of Pathology, Program in Genes and Development, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Lab Invest 84:941-51. 2004
    ..of the PTEN and EGFR signaling pathways, Akt, NFkappaB, and signal transducer and activator of transcription-3 (Stat3) have been shown to play important roles in the control of cell proliferation, apoptosis, and oncogenesis...
  99. ncbi Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis C cirrhosis
    Peter Starkel
    Department and Laboratory of Gastroenterology, St Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium
    J Hepatol 43:687-95. 2005
    In vitro and animal data suggest that alcohol and hepatitis C virus (HCV) proteins might interfere with Stat3 signaling, a potential regulator of liver cell apoptosis and proliferation.
  100. ncbi Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Nature 448:1058-62. 2007
    ..Here we show that dominant-negative mutations in the human signal transducer and activator of transcription 3 (STAT3) gene result in the classical multisystem HIES...
  101. doi Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases
    Stephanie Kreis
    Laboratoire de Biologie et Physiologie Intégrée, University of Luxembourg, 162A Avenue de la Faïencerie, L 1511 Luxembourg, Luxembourg
    Mol Cancer Res 5:1331-41. 2007
    ..play a crucial role in oncogenic signaling where inappropriate and sustained activation of STATs, especially STAT3, is a trait of many different cancers and their derived cell lines...

Research Grants108 found, 100 shown here

  1. Gadiparthi N Rao; Fiscal Year: 2016
    ..we have discovered that besides VEGFA, VEGFB, VEGFC, DLL4 and cleaved NOTCH1 induction, hypoxia activates CREB and STAT3 in the mouse retina in a robust and sustained manner...
  2. Cong Yan; Fiscal Year: 2014
    ..to their cell-surface receptors, IL-6 family members trigger activation (phosphorylation) of signal transducer and activator of transcription 3 (Stat3) by Janus-activated kinases (JAKs)...
  3. STAT3 Structural Determinants
    Nancy C Reich; Fiscal Year: 2012
    ..The signal transducer and activator of transcription 3 (STAT3) plays a pivotal role in both acute and chronic inflammatory responses that ..
  4. Cell signaling as a leukemia biomarker
    JAMES WILLIAM JACOBBERGER; Fiscal Year: 2013
    ..aims are 1) to measure signaling for 2 ligands (Stem cell factor and Flt3-ligand) and 5 endpoints (Erk, Akt, S6, Stat3, and Stat5) on committed myeloid precursor cells in 60 healthy human donors to define the normal ranges for each ..
  5. Adiponectin effects on leptin signaling in hepatocellular carcinoma
    Neeraj Kumar Saxena; Fiscal Year: 2011
    ..recent studies investigating the oncogenic actions of leptin revealed that - i) leptin induces proliferation via Stat3, Akt and ERK activation, ii) leptin-induced phosphorylation of ERK and Akt was dependent on Stat3 activation, and ..
  6. Kevin D Cooper; Fiscal Year: 2014
    ..by human T regulatory cells, and c) that psoriatic T cells exhibit hyper-responsive phosphorylation of STAT3, it is critical to test whether IL-6 and and/or other STAT3-activating cytokines favor escape for Tmem/eff cells ..
  7. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..showed that GBM U87 cells express both chemerin and its receptors and that chemerin signals GBM U87 cells by STAT3 and S6 phosphorylation...
  8. Haojie Huang; Fiscal Year: 2015
    ..b>STAT3 is important for IL-6-induced activation of the AR through its interaction with AR...
  9. Robert A Anders; Fiscal Year: 2014
    ..Second, we link the production of interleukin 6 and stimulation of STAT3 phosphorylation to the lymphotoxin receptor...
  10. Functional Role of IL-6 in Fetal Brain Development and Abnormal Behavior
    Elaine Hsiao; Fiscal Year: 2012
    ..to detect downstream responses of IL-6Ra activation, including phosphorylation of the transcription factors, STAT3 and STAT1...
  11. Mitch A Phelps; Fiscal Year: 2014
    ..One principal mediator in pancreatic cancer is the Signal-Transducer and Activator of Transcription-3 (STAT3) protein...
  12. The Role of IL-6/STAT3 in the Pathogenesis and Progression of Barrett's Esophagus
    Ronnie Fass; Fiscal Year: 2012
    ..tissue to bile acids and gastric acid leads to IL-6 upregulation, increased activation of transcription factor STAT3, apoptosis resistance, and cancer development...
  13. Etty N Benveniste; Fiscal Year: 2016
    ....
  14. Shougang Zhuang; Fiscal Year: 2016
    ..and activation of renal interstitial fibroblasts are accompanied by phosphorylation of signal transducer and activator of transcription 3 (STAT3);3) Blockade of the STAT3 pathway also inhibits activation and proliferation of NRK-..
  15. Targeting STAT3 as a novel approach to cancer therapy
    Said M Sebti; Fiscal Year: 2013
    ..grant proposal is to discover novel anticancer drugs based on designing small synthetic molecules that inhibit STAT3 dimerization and aberrant function in tumors that depend on STAT3 for survival...
  16. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..isoform of LepRs mediates cell signaling via the JAK family of tyrosine kinases and subsequent phosphorylation of STAT3. Deletion of LepR-mediated STAT3 signaling (LRbS1138 s/s) recapitulates the db/db metabolic phenotype, producing ..
  17. Nihal Tumer; Fiscal Year: 2015
    ..Leptin signals via the signal transducer and activator of transcription protein 3 (STAT3) and the nutrient sensing AMP-activated kinase (AMPK)/acetyl CoA carboxylase (ACC) pathways...
  18. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2009
    ..the existence of two subgroups of TRH neurons in the PVN responsive to leptin (direct, through phosphorylation of STAT3, and to [unreadable]-MSH (indirect, through phosphorylation CREB) (1), and since resistance to leptin is mostly ..
  19. Regulation of IL-6-Type Cytokine Cardioprotective Signaling in the Ischemic Heart
    George W Booz; Fiscal Year: 2012
    ..Aim 2 will establish the role of the STAT3 - SOCS3 axis in cardiac endothelial cell function...
  20. IL-6-mediated Jak2/Stat3 signaling and Brain Development
    Jun Tan; Fiscal Year: 2011
    ..Our preliminary studies showed that the citrus bioflavonoid, luteolin, inhibits neuronal JAK2/STAT3 phosphorylation in both murine neuron-like (N2a) cells and primary cultured neuronal cells challenged with mouse ..
  21. George Miller; Fiscal Year: 2016
    ..that TLR-mediated inflammation in these cells provide IL-6 and other pro-inflammatory cytokines that promote STAT3 phosphorylation in the Kras-mutated epithelial cells leading to Notch activation in both epithelial and stromal ..
  22. Yi Zhang; Fiscal Year: 2016
    ..We will examine whether and how STAT3 interacts with NF-?B signaling to control the expression of Dll4 in DCs...
  23. Regulation of chromatin modifications by miRNAs to control cytokine expression
    To Ha Thai; Fiscal Year: 2012
    ..miR-155 target sequences, and miR-155 controls IL-17 and IL-22 production through a pathway distinct from the STAT3 and ROR[unreadable]t/ROR[unreadable] transcriptional pathways;3) mechanistically, we have demonstrated that the ..
  24. STAT Activation: Inactivation Cycle and Activated STAT3 in Cancer Cells
    James E Darnell; Fiscal Year: 2010
    ..but the regulated inactivation of the STATs are vital to proper functioning since over-activity particularly of STAT3 in cancer is widespread...
  25. RAIF SALIM GEHA; Fiscal Year: 2016
    ..observation that DOCK8 functions downstream of TLR9 in B cells, and is essential for TLR9-induced activation of STAT3, which plays an important role in the differentiation of B cells into antibody producing cells, and demonstrated ..
  26. Regulatory T cell control of gut inflammation
    Robert M Samstein; Fiscal Year: 2013
    ..However, the mechanisms that Tregs use to suppress inflammation remain unclear. Conditional deletion of Stat3 in Tregs results in a fatal inflammatory colitis characterized by an imbalance of Th17 responses but not Th1 and ..
  27. Lionel B Ivashkiv; Fiscal Year: 2016
    ..We anticipate that these studies will yield insights about specific regulation of subsets of TLR-inducible cytokines and genes that will be useful in developing therapeutic approaches to modulate specific innate immune functions. ..
  28. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..RANKL appears to be regulated via ERK1/2 and STAT3 phosphorylation...
  29. Serpil C Erzurum; Fiscal Year: 2016
    ..amp;survival, which is dependent on activation of signal transducer and activator of transcription-3 (STAT3), a fundamental regulator of cell survival and angiogenesis...
  30. Role of The Jak-Stat Pathway in Ischemic Preconditioning
    Yu Ting Xuan; Fiscal Year: 2010
    ..and Ser-727 phosphorylation of STATS by using a Tyr-705 dominant negative mutant of STATS and a Ser-727 mutant of STAT3, respectively...
  31. JENNIFER ELYNN YEH; Fiscal Year: 2016
    ..of CD44+ cells in TNBC cell lines, many of which also have constitutive activation of the transcription factor STAT3, suggests that CD44 is not merely a marker of tumor-initiating cells, as it is generally viewed, but rather ..
  32. Dean T Yamaguchi; Fiscal Year: 2016
    ....
  33. Structural consequences of TSC gene mutations in brain
    Peter B Crino; Fiscal Year: 2012
    ..RNAs play a pivotal role in translational regulation and interact with several proteins including EIFs and STAT3 that mediate the effects of TSC1/TSC2 in neurons...
  34. Dae Joon Kim; Fiscal Year: 2016
    ..irradiation it is translocated to the nucleus where it contributes to the inactivation of signal transducer and activator of transcription 3 (Stat3), a well-known oncogenic protein...
  35. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2013
    ..Receptor alpha (PPAR1), 2) Decreases the expression of p21waf1 and 3) Enhances Signal Transducer and Activator of Transcription 3 (STAT-3) phosphorylation despite lower IL-6 levels through decreasing Suppressor of Cytokine ..
  36. A Novel Therapy for Restricted Induction of Tolerance to Treat Diabetes Mellitus
    Kanneganti Murthy; Fiscal Year: 2013
    ..and 2) immunohistochemical identification of T cell subset infiltration and the phosphorylation of T-bet and STAT3. Plasma concentrations of mR-412 will be determined by ELISA and compared to functional outcomes...
  37. STAT3 Functional Defects and a Novel Therapeutic Approach for Hyper IgE Syndrome
    Hans Ochs; Fiscal Year: 2009
    ..Results from these investigations will clarify the function of WASP, explain the phenotypes of WAS/XLT and will undoubtedly have implications for optimal therapy of affected patients. ..
  38. Regulation of Monocyte and Granulocyte Lineage Specification
    Alan D Friedman; Fiscal Year: 2013
    ..GCSFR signals in lineage- negative murine marrow myeloid cells, we find that while G-CSF specifically activates STAT3, M-CSF preferentially activates ERK and thereby stabilizes c-Fos...
  39. Srikanta Dash; Fiscal Year: 2016
    ..iv). We showed that HCV infection does not alter IFN-? receptor-1 expression. IFN-? activates Stat3, AKT and MAPK pathways to inhibit HCV replication and overcomes IFN-[unreadable] /ribavirin resistance mechanisms ..
  40. Role of Epithelium in Immunity, Inflammation and Disease
    Robert P Schleimer; Fiscal Year: 2013
    ..Other recent data from our laboratories show evidence for impairment in activation of STAT3, a molecule that is known to mediate immune and protective responses...
  41. Wenshu Chen; Fiscal Year: 2014
    ..Quercetin also suppresses IL-6-induced Stat3 activation in human bronchial epithelial cells (HBECs)...
  42. Hexin Chen; Fiscal Year: 2016
    ..We have systematically dissected the HER2-downstream signaling pathways and found that the NFkB and STAT3 pathways are the most important for self-renewal of CSCs...
  43. ESTHER AMALIA GUZMAN; Fiscal Year: 2014
    ..RAGE promotes constitutive activation of NFkB and phosphorylation and mitochondrial translocation of STAT3 leading to chronic inflammation and resistance to apoptosis...
  44. The role of the mu-Opioid Receptor in Inflammatory Bowel Disease Pathology and Th
    Jason R Goldsmith; Fiscal Year: 2013
    ..Prelminary studies also show MOR-induced IL-22 mRNA expression in vivo. IL-22 is a potent inducer of STAT3 phosphorylation, and other prelminary data shows the MOR agonist induces STAT3 activation in cultured enterocytes...
  45. Chemical probes that target Stat3 to treat cancer
    DAVID JOHN TWEARDY; Fiscal Year: 2013
    ..population that the top canonical pathways involved in breast TIC self-renewal include Stat3 signaling (3)...
  46. Brian C Betts; Fiscal Year: 2016
    ..Moreover, blockade of downstream STAT3 abrogates alloresponses as a single agent...
  47. Jason C Mills; Fiscal Year: 2016
    ..CD44 activates STAT3 and is induced by ERK signaling...
  48. Interactions of KSHV and endothelial cells
    Michael Lagunoff; Fiscal Year: 2012
    ..Persistent signaling of STAT3 is common in many tumors and is induced by latent KSHV infection of endothelial cells...
  49. Jane Hoyt Buckner; Fiscal Year: 2016
    ..Specifically we address how alterations in the IL-2/STAT5 and IL-6/STAT3 cytokine signaling pathways contribute to the loss of this balance in individuals with T1D, MS and CD...
  50. MARGARET MARY CHOU; Fiscal Year: 2014
    ..We further identified NF?B and STAT3 as key effectors of TRE17 in ABC pathogenesis...
  51. Maternal pro-inflammatory status in obesity regulates placental function
    Theresa L Powell; Fiscal Year: 2013
    ..translation and/or membrane trafficking of specific amino acid transporter isoforms, mediated in part by STAT3. We will address this central hypothesis in three specific aims: 1...
  52. Mien Chie Hung; Fiscal Year: 2014
    ..Later, we demonstrated that EGFR interacts with STAT3 in the nucleus and the EGFR/STAT3 complex recognizes the ATRS and STAT binding sequence of the iNOS promoter and ..
  53. Breast cancer health disparity:mammary fat tissue and tumor macrophages interpla
    Marta Torroella-Kouri; Fiscal Year: 2012
    ..Moreover, the impact of blocking the functions of these paracrine factors on mf 's NFkB and STAT3 activation will be studied....
  54. Susan M Kaech; Fiscal Year: 2016
    ..of mature antiviral memory CD8 T cells and their precursors that involves the actions of IL-10, IL-21 and STAT3. Based on our findings, we hypothesize that memory cell fates are not necessarily "programmed" in activated CD8 T ..
  55. Pak H Chan; Fiscal Year: 2015
    ..We have recently discovered that signal transducer and activator of transcription 3 (STAT3) is a transcription activator of the promoter of manganese-superoxide dismutase (SOD2)..
  56. STAT3 and astrogliogenesis in HIV-1 associated dementia
    Hui Peng; Fiscal Year: 2010
    ..Our preliminary study showed both IL-1b and TNF-a, as well as HIV-1-infected and LPS-activated MP induced STAT3 activation, a critical pathway of astrogliogenesis...
  57. Junxuan Lu; Fiscal Year: 2014
    ..rapid inhibition of DNA replicative synthesis, and an activation of the p53 tumor suppressor and inactivating the Stat3 oncogenic signaling, associated with cyclin D1 (cell cycle) and Bcl-xL/Mcl-1 (cell survival) down regulation...
  58. Richard J Bram; Fiscal Year: 2015
    ..reactive oxygen species (ROS) and decreased levels of Chk1 and mutant p53, as well as decreased activation of Stat3, all of which have been implicated in regulation of cancer cell proliferation, suggesting a mechanism underlying ..
  59. Tatiana Efimova; Fiscal Year: 2014
    ..and angiogenic mediators, including COX2, VEGF1, and AP1, as well as activation of oncogenic transcription factor Stat3, are abrogated in p384-null setting...
  60. Role of Id1 in NSCLC Progression and Metastasis
    Srikumar P Chellappan; Fiscal Year: 2013
    ..We hypothesize that both nAChRs and EGFR induce Id1 in a Src and STAT3-dependent fashion and contributes to the invasive and metastatic properties of these cancers...
  61. SRINIVAS RAVI V IYENGAR; Fiscal Year: 2016
    ..The findings using agonists that activate the cannabinoid-1 (CB1)receptor-Go/i and interlukin-6 (IL60 receptor-JAK-STAT3 network suggested that there may be many components in the regulatory networks involved in subcellular processes ..
  62. Interleukin-6/Stat3 regulation of the Estrogen Receptor Alpha in Breast Cancer
    JENNIFER EBELE NNOLI; Fiscal Year: 2013
    ..The work proposed here will reveal a novel role for the IL-6/Jak/Stat3 pathway in modulating ER expression through epigenetic modification of the ER promoter and may lead to targeted ..
  63. James Versalovic; Fiscal Year: 2016
    ..to histamine, suppress chronic intestinal inflammation and inflammation-associated colonic neoplasia by regulating Stat3 and MAP kinase signaling pathways...
  64. ELIZABETH ANN EKLUND; Fiscal Year: 2016
    ..Gas2 inhibits calpain;a serine protease with substrates that include bcate-nin, Stat3, Stat5 and Xiap...
  65. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..components responsible for LIF action (glycoprotein 130, or gp130;janus kinase 1, or JAK1;signal transducer and activator of transcription 3, or STAT3) were also highest in unruptured rhesus macaque follicles 12 h after hCG ..
  66. Julie S Barber-Rotenberg; Fiscal Year: 2015
    ..Upregulation of STAT3 is found in many human cancers, including breast, prostate, and melanoma...
  67. Arianne L Theiss; Fiscal Year: 2014
    ..Furthermore, our recent data show that PHB interacts with STAT3 in colon mucosa and cultured intestinal epithelial cell lines and modulates its downstream apoptotic responses...
  68. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..Increased Stat3 activity was observed in the lungs of IL-6-treated vs...
  69. Interleukin-6 Expression and Function in Adipose Cells
    Jianbei Deng; Fiscal Year: 2006
    ..IL-6 traditionally signals through STAT3 activation, but in differentiating preadipocytes, IL-6 inhibits and STAT3 appears to be necessary for adipocyte ..
  70. Christine Schwartz; Fiscal Year: 2014
    ..transcriptome sequencing shows that genes encoding regulatory proteins of well- known survival pathways, JAK3, STAT3, AKT1, MAPK1/3 are significantly upregulated during torpor and IBA...
  71. Michael Karin; Fiscal Year: 2016
    ..In this respect, we will investigate how loss of the APC tumor suppressor, NF-?B and STAT3 activation in pre-malignant IEC results in loss of junctional proteins and mucin expression, thereby contributing ..
  72. Translational Insights into Estrogen Receptor alpha-Positive Luminal Breast Cance
    ROBERT DAVID SCHREIBER; Fiscal Year: 2013
    ..mammary tumors from STAT1-/- mice, placing special emphasis on defining the role(s) of the hyperactivated JAK2-STAT3/5 signaling pathway that is operative in these tumor cells, and in identifying differentially expressed proteins ..
  73. Fu Dong Shi; Fiscal Year: 2014
    ..Also, the absence of NK cells promoted the activation of the Th17 lineage-specific transcription factors Rorc and STAT3 in a manner that was dependent on microglia...
  74. Wael El-Rifai; Fiscal Year: 2016
    ..transcription up-regulation of DARPP-32 by NF-kB connects cancer cell signaling pathways leading to activation of STAT3, thereby placing DARPP-32 as a bridge between two important signaling pathways amplifying their oncogenic signals ..
  75. Edaire Cheng; Fiscal Year: 2016
    ..effects of IL-13, IL-4, and periostin on esophageal fibroblast;(3) To confirm that IL-13 and/or IL-4 can cause STAT3-mediated periostin expression and fibrotic effects in organotypic models, and to correlate STAT3 pathway ..
  76. Peter J Houghton; Fiscal Year: 2016
    ..by an increase in the MEK-dependent gene signature, enhanced IL-6 transcription and secretion, and activation of STAT3 signaling...
  77. Neil A Bhowmick; Fiscal Year: 2016
    ..In the last funding cycle we also identified that the knockout of Tgfbr2 up regulates Stat3 signaling...
  78. Cynthia Ju; Fiscal Year: 2016
    ..c) The STAT3hep/- mice will be utilized to examine the role of hepatocyte-specific STAT3 signaling in BMMC accumulation in the liver after alcohol exposure...
  79. PAUL MICHAEL TITCHENELL; Fiscal Year: 2015
    ..Preliminary data suggest that Stat3 is activated in livers null for Akt and Foxo1...
  80. Cellular plasticity and survival mechanisms in medulloblastoma stem cells
    Ronnie Yoo; Fiscal Year: 2013
    ..in the survival and plasticity, I will first determine the gene expression profile of the MBSC and the rol of STAT3 in the MBSC...
  81. Targeted theranostic microbubble vectors for transcription factor decoy delivery
    Flordeliza S Villanueva; Fiscal Year: 2013
    ..We will utilize the STAT3 decoy as a test therapeutic, as this small nucleic acid is known to have therapeutic potential and safety in ..
  82. Zheng W Chen; Fiscal Year: 2015
    ..T cell subsets are more activated as they expressed much higher levels of phosphorylated signaling molecules p38, stat3, stat5, and Erk1/2 than Tim-3- controls...
  83. Carole A Oskeritzian; Fiscal Year: 2015
    ..pharmacological, molecular and genetic approaches, we have discovered a new signaling pathway linking S1P2 to Stat3 transcription factor and how disrupting this pathway may potentially abrogate aspects of remodeling observed in ..
  84. Noah D Peyser; Fiscal Year: 2014
    ..Increased activation of Signal Transducer and Activator of Transcription-3 (STAT3) has been implicated in OSCC tumorigenesis and progression...
  85. CONTEMPORARY THERAPEUTICS FOR ANAPLASTIC GLIOMAS
    G Yancey Gillespie; Fiscal Year: 2013
    ..These include: 1)Targeted'Intervention of the JAK2/STAT3 Signaling Axis for Anaplastic Glioma Therapy \o develop a rational basis for inhibiting the JAK2/STAT3 pathway ..
  86. Lee Quinton; Fiscal Year: 2016
    ..pneumonia, the cytokine leukemia inhibitory factor (LIF) is critical for activation of the transcription factor STAT3, which has emerged as an important signaling hub for both antimicrobial defense and tissue protection in the lungs ..
  87. Potent organometallic inhibitors of Signal Transducer and Activator of Transcript
    ZACHARY THOMAS BALL; Fiscal Year: 2013
    ..There is a large unmet need for new AML treatment options. The signal transducer and activator of transcription 3 (STAT3) protein is a potentially powerful new therapeutic target for the treatment of ..
  88. Novel Therapeutic Strategy for Refractory and Relapse Childhood Acute Leukemia
    Mark R Kelley; Fiscal Year: 2013
    ..downstream targets involved in cancer growth, metabolism and drug resistance (NF-?B, AP-1, HIF-1[unreadable], STAT3), coupled with our previous studies with E3330 as a specific Ref-1 redox inhibitor and our preliminary data on T-..
  89. ANDREW TAYANJANA NAMANJA; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The Signal Transducer and Activator of Transcription 3 (STAT3) is persistently activated in many types of cancers, including breast, prostate, leukemia and lymphoma, to support oncogenesis...
  90. Addanki Pratap Kumar; Fiscal Year: 2016
    ..and activity of two key redox-regulated transcription factors that control oncogenic signaling namely NF?B and Stat3 that results in modulation of anti-apoptotic protein FLIP...
  91. MATTHEW MINUS; Fiscal Year: 2015
    ..A significant body of research has pointed to STAT3 as a promising new target for the treatment of drug-resistant tumors...
  92. Zhenghe Wang; Fiscal Year: 2016
    ..Using a cutting-edge phospho-proteomic approach, we identified STAT3 and paxillin as PTPRT substrates. PTPRT dephosphorylates the key STAT3 activation site Y705...
  93. SHANNON CELESTE KENNEY; Fiscal Year: 2016
    ..through its ability to induce ATM/p53-dependent lytic EBV reactivation, and to inhibit essential EBV-activated cellular pathways (including c-myc, NF-Kappa B, and STAT3) that are required for the viability of EBV-transformed B cells.
  94. Ichiro Nakano; Fiscal Year: 2016
    ..This pathway involves the mitotic kinase MELK, methyl transferase EZH2, and oncogenic transcription factor STAT3. Importantly, dysregulation of this pathway accelerates GSC growth and promotes GBM malignancy, and are tightly ..
  95. Keith Syson Chan; Fiscal Year: 2016
    ..Finally, Aim 3 will access Stat3 and additional downstream mechanisms related to DDR1, using established proteomics profiling approach...
  96. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..amp;survival, which is dependent on activation of signal transducer and activator of transcription-3 (STAT3), a fundamental regulator of cell survival and angiogenesis...