stearoyl CoA desaturase

Summary

Gene Symbol: stearoyl CoA desaturase
Description: stearoyl-CoA desaturase
Alias: FADS5, MSTP008, SCD1, SCDOS, hSCD1, acyl-CoA desaturase, delta(9)-desaturase, fatty acid desaturase, stearoyl-CoA desaturase (delta-9-desaturase), stearoyl-CoA desaturase opposite strand
Species: human
Products:     stearoyl CoA desaturase

Top Publications

  1. Attie A, Krauss R, Gray Keller M, Brownlie A, Miyazaki M, Kastelein J, et al. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res. 2002;43:1899-907 pubmed
    ..Mice with a targeted disruption of the SCD1 gene have very low levels of VLDL and impaired triglyceride and cholesterol ester biosynthesis...
  2. Du X, Wang Q, Chan E, Merchant M, Liu J, French D, et al. FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth. Cancer Res. 2012;72:5843-55 pubmed publisher
    ..In turn, SREBP1 regulates the expression of key lipogenic enzymes, including stearoyl CoA desaturase 1 (SCD1/SCD)...
  3. Zhang L, Ge L, Parimoo S, Stenn K, Prouty S. Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J. 1999;340 ( Pt 1):255-64 pubmed
    ....
  4. Shiwaku K, Hashimoto M, Kitajima K, Nogi A, Anuurad E, Enkhmaa B, et al. Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians. J Lipid Res. 2004;45:914-22 pubmed
    ..HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians. ..
  5. Moore S, Knudsen B, True L, Hawley S, Etzioni R, Wade C, et al. Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma. Int J Cancer. 2005;114:563-71 pubmed
    ..These results indicate that loss of SCD expression is a frequent event in prostate adenocarcinoma, and further supports a role for altered lipid metabolism as a factor in the process of carcinogenesis. ..
  6. Scaglia N, Caviglia J, Igal R. High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts. Biochim Biophys Acta. 2005;1687:141-51 pubmed
    ..The strong correlation of high levels of MUFA and neoplastic phenotype suggest that the regulation of stearoyl CoA desaturase (SCD) must play a significant role in cancer development...
  7. Gong J, Campos H, McGarvey S, Wu Z, Goldberg R, Baylin A. Genetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults. J Nutr. 2011;141:2211-8 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) activity, a key regulator of lipid metabolism, may be associated with the development of metabolic syndrome (MetS)...
  8. Scaglia N, Chisholm J, Igal R. Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PLoS ONE. 2009;4:e6812 pubmed publisher
    ..We have previously shown that a stable knockdown of stearoyl-CoA desaturase 1 (SCD1), the main Delta9-desaturase that converts SFA into MUFA, in cancer cells decreases the rate of lipogenesis, ..
  9. Mason P, Liang B, Li L, Fremgen T, Murphy E, Quinn A, et al. SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLoS ONE. 2012;7:e33823 pubmed publisher
    ..Using RNAi we have demonstrated that depletion of fatty-acid synthesis pathway enzymes SCD1, FASN, or ACC1 in HCT116 colon cancer cells results in cytotoxicity that is reversible by addition of exogenous ..
  10. Li J, Ding S, Habib N, Fermor B, Wood C, Gilmour R. Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues. Int J Cancer. 1994;57:348-52 pubmed
    ..It is suggested that certain classes of tumour may exhibit increased levels of desaturase mRNA. ..

Detail Information

Publications62

  1. Attie A, Krauss R, Gray Keller M, Brownlie A, Miyazaki M, Kastelein J, et al. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res. 2002;43:1899-907 pubmed
    ..Mice with a targeted disruption of the SCD1 gene have very low levels of VLDL and impaired triglyceride and cholesterol ester biosynthesis...
  2. Du X, Wang Q, Chan E, Merchant M, Liu J, French D, et al. FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth. Cancer Res. 2012;72:5843-55 pubmed publisher
    ..In turn, SREBP1 regulates the expression of key lipogenic enzymes, including stearoyl CoA desaturase 1 (SCD1/SCD)...
  3. Zhang L, Ge L, Parimoo S, Stenn K, Prouty S. Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J. 1999;340 ( Pt 1):255-64 pubmed
    ....
  4. Shiwaku K, Hashimoto M, Kitajima K, Nogi A, Anuurad E, Enkhmaa B, et al. Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians. J Lipid Res. 2004;45:914-22 pubmed
    ..HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians. ..
  5. Moore S, Knudsen B, True L, Hawley S, Etzioni R, Wade C, et al. Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma. Int J Cancer. 2005;114:563-71 pubmed
    ..These results indicate that loss of SCD expression is a frequent event in prostate adenocarcinoma, and further supports a role for altered lipid metabolism as a factor in the process of carcinogenesis. ..
  6. Scaglia N, Caviglia J, Igal R. High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts. Biochim Biophys Acta. 2005;1687:141-51 pubmed
    ..The strong correlation of high levels of MUFA and neoplastic phenotype suggest that the regulation of stearoyl CoA desaturase (SCD) must play a significant role in cancer development...
  7. Gong J, Campos H, McGarvey S, Wu Z, Goldberg R, Baylin A. Genetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults. J Nutr. 2011;141:2211-8 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) activity, a key regulator of lipid metabolism, may be associated with the development of metabolic syndrome (MetS)...
  8. Scaglia N, Chisholm J, Igal R. Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PLoS ONE. 2009;4:e6812 pubmed publisher
    ..We have previously shown that a stable knockdown of stearoyl-CoA desaturase 1 (SCD1), the main Delta9-desaturase that converts SFA into MUFA, in cancer cells decreases the rate of lipogenesis, ..
  9. Mason P, Liang B, Li L, Fremgen T, Murphy E, Quinn A, et al. SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLoS ONE. 2012;7:e33823 pubmed publisher
    ..Using RNAi we have demonstrated that depletion of fatty-acid synthesis pathway enzymes SCD1, FASN, or ACC1 in HCT116 colon cancer cells results in cytotoxicity that is reversible by addition of exogenous ..
  10. Li J, Ding S, Habib N, Fermor B, Wood C, Gilmour R. Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues. Int J Cancer. 1994;57:348-52 pubmed
    ..It is suggested that certain classes of tumour may exhibit increased levels of desaturase mRNA. ..
  11. Holder A, Gonzalez Angulo A, Chen H, Akcakanat A, Do K, Fraser Symmans W, et al. High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients. Breast Cancer Res Treat. 2013;137:319-27 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) is an essential regulator of fatty acid synthesis. We have previously shown that overexpression of SCD1 increases the growth of breast cancer cell lines...
  12. Mauvoisin D, Charfi C, Lounis A, Rassart E, Mounier C. Decreasing stearoyl-CoA desaturase-1 expression inhibits β-catenin signaling in breast cancer cells. Cancer Sci. 2013;104:36-42 pubmed publisher
    Stearoyl-CoA desaturase-1 (SCD1) is an endoplasmic reticulum anchored enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly palmytoleyl-CoA and oleyl-CoA...
  13. Mauvoisin D, Mounier C. Hormonal and nutritional regulation of SCD1 gene expression. Biochimie. 2011;93:78-86 pubmed publisher
    Stearoyl-CoA Desaturase 1 (SCD1) is the rate limiting enzyme catalyzing the biosynthesis of monounsaturated fatty acids preferentially from palmitoyl-CoA and stearoyl-CoA forming respectively palmitoleyl-CoA and oleyl-CoA...
  14. Scaglia N, Igal R. Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. Int J Oncol. 2008;33:839-50 pubmed
    ..of tissue MUFA and several types of cancer has been reported, but a causal relationship between the function of SCD1, the main human SCD isoform, and cancer development has not yet been firmly established...
  15. Hulver M, Berggren J, Carper M, Miyazaki M, Ntambi J, Hoffman E, et al. Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab. 2005;2:251-61 pubmed
    ..Herein, we show that the lipogenic gene, stearoyl-CoA desaturase 1 (SCD1), is robustly up-regulated in skeletal muscle from extremely obese humans...
  16. Kotronen A, Seppanen Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepää A, et al. Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. Diabetes. 2009;58:203-8 pubmed publisher
    To determine whether 1) hepatic ceramide and diacylglycerol concentrations, 2) SCD1 activity, and 3) hepatic lipogenic index are increased in the human nonalcoholic fatty liver...
  17. Zhou Y, Egeland G, Meltzer S, Kubow S. The association of desaturase 9 and plasma fatty acid composition with insulin resistance-associated factors in female adolescents. Metabolism. 2009;58:158-66 pubmed publisher
    ....
  18. Stefan N, Peter A, Cegan A, Staiger H, Machann J, Schick F, et al. Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans. Diabetologia. 2008;51:648-56 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) is the rate-limiting enzyme in monounsaturated fatty acid synthesis. It is imperative for the assembly of VLDL particles, which transport triacylglycerol (TG) from liver to adipose tissue and other sites...
  19. Minville Walz M, Pierre A, Pichon L, Bellenger S, Fèvre C, Bellenger J, et al. Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells. PLoS ONE. 2010;5:e14363 pubmed publisher
    ..This change in fatty acid metabolism is associated with overexpression of stearoyl-CoA desaturase 1 (Scd1), which catalyses the transformation of saturated fatty acids into monounsaturated fatty acids (e.g., oleic acid)...
  20. Scaglia N, Igal R. Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells. J Biol Chem. 2005;280:25339-49 pubmed
    ....
  21. Mar Heyming R, Miyazaki M, Weissglas Volkov D, Kolaitis N, Sadaat N, Plaisier C, et al. Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 2008;28:1193-9 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) is the rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, and in mice SCD1 activity is associated with plasma triglyceride levels...
  22. von Roemeling C, Marlow L, Wei J, Cooper S, Caulfield T, Wu K, et al. Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res. 2013;19:2368-80 pubmed publisher
    We set out to identify Stearoyl-CoA desaturase 1 (SCD1) as a novel molecular target in clear cell renal cell carcinoma (ccRCC) and examine its role in tumor cell growth and viability in vitro and in vivo independently as well as in ..
  23. Ide Y, Waki M, Hayasaka T, Nishio T, Morita Y, Tanaka H, et al. Human breast cancer tissues contain abundant phosphatidylcholine(36∶1) with high stearoyl-CoA desaturase-1 expression. PLoS ONE. 2013;8:e61204 pubmed publisher
    ..The protein expression of stearoyl-CoA desaturase-1 (SCD1), which is a synthetic enzyme of MUFA, showed accumulation in the cancerous areas as observed by the results of ..
  24. Liew C, Groves C, Wiltshire S, Zeggini E, Frayling T, Owen K, et al. Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. Diabetologia. 2004;47:2168-75 pubmed
    ..Although this study provided no evidence that SCD sequence variation influences diabetes susceptibility or related traits, SCD remains a major target for pharmaceutical and/or environmental manipulation. ..
  25. Wang J, Yu L, Schmidt R, Su C, Huang X, Gould K, et al. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Biochem Biophys Res Commun. 2005;332:735-42 pubmed
    ..Microsome fractions prepared from hSCD1 and hSCD5 transfected cells displayed similar delta 9 desaturase activity...
  26. Peter A, Cegan A, Wagner S, Elcnerova M, Konigsrainer A, Königsrainer I, et al. Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans. Am J Physiol Endocrinol Metab. 2011;300:E321-6 pubmed publisher
    Stearoyl-CoA desaturase-1 (SCD1) has gained much interest as a future drug target to treat fatty liver and its consequences. However, there are few and inconsistent human data about expression and activity of this important enzyme...
  27. Warensjo E, Ingelsson E, Lundmark P, Lannfelt L, Syvanen A, Vessby B, et al. Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity. Obesity (Silver Spring). 2007;15:1732-40 pubmed
    ..The lipogenic enzyme, stearoyl-coenzyme A-desaturase (SCD), is related to obesity. Further, SCD1-deficent mice are protected against obesity and insulin resistance...
  28. McNamara R, Liu Y, Jandacek R, Rider T, Tso P. The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity. Prostaglandins Leukot Essent Fatty Acids. 2008;78:293-304 pubmed publisher
    ..The implications of age-related reductions in OFC PUFA composition for affective dysregulation in the elderly are discussed. ..
  29. Noubiap J, Mengnjo M, Nicastro N, Kamtchum Tatuene J. Neurologic complications of sickle cell disease in Africa: A systematic review and meta-analysis. Neurology. 2017;89:1516-1524 pubmed publisher
    ....
  30. Khemani K, Ross D, Sinha C, Haight A, Bakshi N, Krishnamurti L. Experiences and Decision Making in Hematopoietic Stem Cell Transplant in Sickle Cell Disease: Patients' and Caregivers' Perspectives. Biol Blood Marrow Transplant. 2017;: pubmed publisher
    ..Understanding the key influential factors in decision making and the impact HSCT has on these patients and their families will generate crucial insights that can guide the care of future patients and research studies. ..
  31. Müller S, Preische O, Göpfert J, Yañez V, Joos T, Boecker H, et al. Tau plasma levels in subjective cognitive decline: Results from the DELCODE study. Sci Rep. 2017;7:9529 pubmed publisher
    ..In conclusion, plasma tau is not increased in SCD patients. In addition, the lack of correlation between tau in plasma and CSF in the examined cohort suggests that tau levels are affected by different factors in both biofluids. ..
  32. Siqingaowa -, Sekar S, Gopalakrishnan V, Taghibiglou C. Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation. Biochem Biophys Res Commun. 2017;488:136-140 pubmed publisher
    ..Our in vitro data suggest that SREBP1 may contribute to pancreatic tumor growth and its inhibitors could be considered as a potential target in the management of pancreatic cancer cell proliferation. ..
  33. Puri L, Nottage K, Hankins J, Anghelescu D. State of the Art Management of Acute Vaso-occlusive Pain in Sickle Cell Disease. Paediatr Drugs. 2017;: pubmed publisher
    ..This report reviews the mechanisms of pain associated with acute VOC, describes the current management of VOC, and describes some of the new therapies under evaluation for the management of acute VOC in SCD. ..
  34. Nakaya K, Ayaori M, Uto Kondo H, Sotherden G, Nishida T, Katamoto H, et al. Overexpression of stearoyl-coenzyme A desaturase 1 in macrophages promotes reverse cholesterol transport. Biochim Biophys Acta. 2013;1831:1402-11 pubmed publisher
    Stearoyl-coenzyme A desaturase 1 (SCD1) is the rate-limiting enzyme in the synthesis of monounsaturated fatty acids. However, the impact of SCD1 on atherosclerosis remains unclear...
  35. Jeyakumar S, Sheril A, Vajreswari A. Vitamin A Improves Hyperglycemia and Glucose-Intolerance through Regulation of Intracellular Signaling Pathways and Glycogen Synthesis in WNIN/GR-Ob Obese Rat Model. Prev Nutr Food Sci. 2017;22:172-183 pubmed publisher
    Vitamin A and its metabolites modulate insulin resistance and regulate stearoyl-CoA desaturase 1 (SCD1), which are also known to affect insulin resistance...
  36. Winchenne A, Cecchini J, Deux J, de Prost N, Razazi K, Carteaux G, et al. A clinical risk score for pulmonary artery thrombosis during acute chest syndrome in adult patients with sickle cell disease. Br J Haematol. 2017;179:627-634 pubmed publisher
    ..The negative predictive value of a PAT-ACS risk score ≥2 was 94%. In conclusion, we propose a simple clinical risk score to identify SCD patients at high risk of PAT during ACS...
  37. Agarwal N, Iyer D, Gabbi C, Saha P, Patel S, Mo Q, et al. HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD. Sci Rep. 2017;7:13362 pubmed publisher
    ..liver X receptor-α (LXRα) with increased expression of its lipogenic targets Srebp1c, Chrebp, Lpk, Dgat, Fasn and Scd1, and intranuclear SREBP1c and ChREBP...
  38. Martin O, Moquist K, Hennessy J, Nelson S. Invasive pneumococcal disease in children with sickle cell disease in the pneumococcal conjugate vaccine era. Pediatr Blood Cancer. 2018;65: pubmed publisher
    ..Further study is needed to characterize the incidence of and risk factors for the development of IPD in SCD in the PCV era to help drive better prevention strategies...
  39. Fontao F, Barnes L, Kaya G, Saurat J, Sorg O. High susceptibility of Lrig1 sebaceous stem cells to TCDD in mice. Toxicol Sci. 2017;: pubmed publisher
    ..within the glands, and (iii) a dramatic repression of the genes encoding the sebogenic enzymes AWAT1, ELOVL3 and SCD1. These effects were reversible...
  40. Garcia C, Duby C, Catheline D, Toral P, Bernard L, Legrand P, et al. Synthesis of the suspected trans-11,cis-13 conjugated linoleic acid isomer in ruminant mammary tissue by FADS3-catalyzed Δ13-desaturation of vaccenic acid. J Dairy Sci. 2017;100:783-796 pubmed publisher
    ..However, in rodents, the fatty acid desaturase 3 (FADS3) gene was recently shown to code for an enzyme able to catalyze the unexpected Δ13-desaturation ..
  41. Lee M, Shin Y, Jung S, Kim S, Jo Y, Kim C, et al. The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response. Molecules. 2017;22: pubmed publisher
    ..These results suggest that TBEs may inhibit adipogenesis and inflammatory response; therefore, they seem to be beneficial as a food ingredient to prevent obesity-associated inflammation. ..
  42. Nashed M, Chisholm J, Igal R. Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells. Exp Biol Med (Maywood). 2012;237:1007-17 pubmed
    Stearoyl-CoA desaturase-1 (SCD1), the main enzyme that converts saturated fatty acids into monounsaturated fatty acids, is a key factor in the mechanisms of cancer cell proliferation, survival and tumorigenesis...
  43. Shi H, Zhang C, Zhao W, Luo J, Loor J. Peroxisome proliferator-activated receptor delta facilitates lipid secretion and catabolism of fatty acids in dairy goat mammary epithelial cells. J Dairy Sci. 2017;100:797-806 pubmed publisher
    ..Collectively, these results highlight an important role for PPARD in the homeostasis of ruminant mammary cells by facilitating fatty acid activation and lipid droplet formation and secretion. ..
  44. Thomsen K, Laposata M, Njoroge S, Umunakwe O, Katrangi W, Seegmiller A. Increased elongase 6 and Δ9-desaturase activity are associated with n-7 and n-9 fatty acid changes in cystic fibrosis. Lipids. 2011;46:669-77 pubmed publisher
    ..Taken together, these findings suggest that fatty acid abnormalities of the n-7 and n-9 series in cystic fibrosis are as a result, at least in part, of increased expression and activity of these metabolic enzymes in CFTR-mutated cells. ..
  45. Ikaga R, Li D, Yamazaki T. Dietary β-conglycinin prevents acute ethanol-induced fatty liver in mice. Biochem Biophys Res Commun. 2017;493:542-547 pubmed publisher
    ....
  46. Magnusson P, Morner S. EvaLuation Using Cardiac Insertable Devices And TelephonE in Hypertrophic Cardiomyopathy (ELUCIDATE HCM)-rationale and design: a prospective observational study on incidence of arrhythmias in Sweden. BMJ Open. 2017;7:e019541 pubmed publisher
    ..The remaining time the potential burden arrhythmia is unknown. Therefore, the aim of the present study is to assess NSVT and AF incidence during 18 months by an insertable cardiac monitor (ICM)...
  47. Zhang J, Song F, Zhao X, Jiang H, Wu X, Wang B, et al. EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer. Mol Cancer. 2017;16:127 pubmed publisher
    ..This is the focus of our study. The interaction between EGFR and stearoyl-CoA desaturase-1 (SCD1) was detected byco-immunoprecipitation...
  48. Ilyas I, Alrumaih H, Rabbani S. Noncemented Total Hip Arthroplasty in Sickle-Cell Disease: Long-Term Results. J Arthroplasty. 2017;: pubmed publisher
    ..Avascular necrosis of the femoral head is a well-known sequela of sickle-cell disease (SCD) requiring a surgical intervention that comes with technical challenges...
  49. Wakefield E, Popp J, Dale L, Santanelli J, Pantaleao A, Zempsky W. Perceived Racial Bias and Health-Related Stigma Among Youth with Sickle Cell Disease. J Dev Behav Pediatr. 2017;38:129-134 pubmed publisher
    ..The purpose of this study was to investigate the occurrence of perceived racial bias and health-related stigma among youth with SCD and its relationship with psychological and physical well-being...
  50. Nio Y, Hasegawa H, Okamura H, Miyayama Y, Akahori Y, Hijikata M. Liver-specific mono-unsaturated fatty acid synthase-1 inhibitor for anti-hepatitis C treatment. Antiviral Res. 2016;132:262-7 pubmed publisher
    ..The results suggest that MK8245 is an option for anti-HCV multi-drug therapy with a low risk of emergence of drug-resistant HCV without significant side effects. ..
  51. Bacchi S, Chim I, Kramer P, Postuma R. Domperidone for Hypotension in Parkinson's Disease: A Systematic Review. J Parkinsons Dis. 2017;7:603-617 pubmed publisher
    ..However, domperidone use in PD is tempered by concerns regarding QT prolongation and ventricular tachyarrhythmia and sudden cardiac death (VT/SCD)...
  52. Carvalho M, Souza A, Carvalho M, Pacheco A, Rocha L, do Nascimento V, et al. Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease. Front Immunol. 2017;8:1491 pubmed publisher
    ..In summary, AAT may need to be included in studies related to SCD and in the discussion of further therapeutic strategies...
  53. Kucharski M, Kaczor U. [Stearoyl-CoA desaturase--the lipid metabolism regulator]. Postepy Hig Med Dosw (Online). 2014;68:334-42 pubmed publisher
    ..Also, it seems that using sheep as a potential animal model could be helpful in uncovering and understanding the mechanisms regulated by stearoyl-CoA desaturase. ..
  54. Nkya S, Mgaya J, Urio F, Makubi A, Thein S, Menzel S, et al. Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania. EBioMedicine. 2017;23:146-149 pubmed publisher
    ..In SCD, improving SpO2, in part through cardiovascular compensation and associated with reduced reticulocytosis, may be a mechanism by which HbF reduces disease severity. ..
  55. Wijnberge M, Parmar K, Kesse Adu R, Howard J, Cohen A, Hunt B. The utility of thromboelastography and thrombin generation in assessing the prothrombotic state of adults with sickle cell disease. Thromb Res. 2017;158:113-120 pubmed publisher
    ....
  56. Magi S, Lariccia V, Maiolino M, Amoroso S, Gratteri S. Sudden cardiac death: focus on the genetics of channelopathies and cardiomyopathies. J Biomed Sci. 2017;24:56 pubmed publisher
    ..Functional alterations of the related proteins are also described. ..
  57. Souza C, Vannice G, Neto J, Calder P. Is Palmitoleic Acid a Plausible Non-Pharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?. Mol Nutr Food Res. 2017;: pubmed publisher
    ..Therefore more human-based research is needed in order to identify whether palmitoleic acid meets the promising therapeutic potential suggested by the pre-clinical research. This article is protected by copyright. All rights reserved...
  58. Vogel J, Varga Doležalová M, La Joie R, Marks S, Schwimmer H, Landau S, et al. Subjective cognitive decline and β-amyloid burden predict cognitive change in healthy elderly. Neurology. 2017;89:2002-2009 pubmed publisher
    ..To assess in a longitudinal study whether subjective cognitive decline (SCD) and brain β-amyloid (Aβ) contribute unique information to cognitive decline...
  59. Leong I, Stuckey A, Belluoccio D, Fan V, Skinner J, Prosser D, et al. Massively Parallel Sequencing of Genes Implicated in Heritable Cardiac Disorders: A Strategy for a Small Diagnostic Laboratory. Med Sci (Basel). 2017;5: pubmed publisher
    ....
  60. Wang X, Wu C, Wang H, Gonsamo A, Liu Z. No evidence of widespread decline of snow cover on the Tibetan Plateau over 2000-2015. Sci Rep. 2017;7:14645 pubmed publisher
    ..The roles of temperature and precipitation on snow cover penology varied in different elevation zones, and the impact of both temperature and precipitation strengthened as elevation increases. ..
  61. Adegoke S, Braga J, D Adekile A, Figueiredo M. Impact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Disease. J Pediatr Hematol Oncol. 2017;: pubmed publisher
    ..To evaluate the impact of hydroxyurea (HU) on nutritional status and serum 25-hydroxyvitamin D (25-OHD) of children with sickle cell disease (SCD)...
  62. Asadollahpour Nanaei H, Ansari Mahyari S, Edriss M. Effect of LEPR, ABCG2 and SCD1 gene polymorphisms on reproductive traits in the Iranian Holstein cattle. Reprod Domest Anim. 2014;49:769-74 pubmed publisher
    ..located in the ATP-binding cassette superfamily G member 2 transporter (ABCG2), stearoyl-CoA desaturase 1 (SCD1) and leptin receptor (LEPR) genes on reproductive traits and somatic cell count (SCC)...