stratifin

Summary

Gene Symbol: stratifin
Description: stratifin
Alias: YWHAS, 14-3-3 protein sigma, 14-3-3 sigma, epithelial cell marker protein 1
Species: human

Top Publications

  1. ncbi Stratifin-induced matrix metalloproteinase-1 in fibroblast is mediated by c-fos and p38 mitogen-activated protein kinase activation
    Eugene Lam
    Wound Healing Research Group, Department of Surgery, University of Alberta, Edmonton, AB, Canada
    J Invest Dermatol 125:230-8. 2005
  2. ncbi Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3
    Vivek Bhalla
    Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0532, USA
    Mol Endocrinol 19:3073-84. 2005
  3. pmc Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3
    Sindhu Rajan
    Institute of Physiology, Marburg University, Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 545:13-26. 2002
  4. doi Cooperative effect of p21Cip1/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF
    P G Hemmati
    Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charite, Campus Berlin Buch, Germany
    Oncogene 27:6707-19. 2008
  5. ncbi Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437
    Arun K Rishi
    Veterans Affairs Medical Center, Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 278:33422-35. 2003
  6. ncbi Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas
    Ekkehard Kunze
    Department of Osteopathology and Haematopathology, University of Gottingen, D 37099 Göttingen, Germany
    Int J Mol Med 18:547-57. 2006
  7. ncbi Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells
    G L Prasad
    Cell and Molecular Physiology Section, National Cancer Institute, Bethesda, Maryland 20892
    Cell Growth Differ 3:507-13. 1992
  8. ncbi Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway
    H Leffers
    Institute of Medical Biochemistry, Danish Centre for Human Genome Research, Aarhus University
    J Mol Biol 231:982-98. 1993
  9. ncbi 14-3-3sigma is a p53-regulated inhibitor of G2/M progression
    H Hermeking
    Johns Hopkins Oncology Center, Baltimore, Maryland, USA
    Mol Cell 1:3-11. 1997
  10. ncbi 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
    T A Chan
    The Johns Hopkins Oncology Center, Program in Human Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 401:616-20. 1999

Research Grants

  1. Moving toward Axon Protection and Remyelination Therapies in Man
    Timothy Coetzee; Fiscal Year: 2006
  2. ANGIOGENESIS INHIBITORS: A MECHANISM OF ACTION
    Erkki Ruoslahti; Fiscal Year: 2006
  3. Emily Ho; Fiscal Year: 2014
  4. Antioxidants and Antiinflammatory in Colorectal Cancer
    Ah Ng Tony Kong; Fiscal Year: 2012
  5. Fung Lung Chung; Fiscal Year: 2014
  6. Isothiocyanates as specific antagonists of human SXR
    David Eaton; Fiscal Year: 2009
  7. Dietary HDAC Inhibitors in Colon Cancer Prevention
    Roderick H Dashwood; Fiscal Year: 2012
  8. Richard L Eckert; Fiscal Year: 2016
  9. 7th National Headache Foundation Research Summit
    Rima Dafer; Fiscal Year: 2009
  10. Louise R Howe; Fiscal Year: 2014

Detail Information

Publications231 found, 100 shown here

  1. ncbi Stratifin-induced matrix metalloproteinase-1 in fibroblast is mediated by c-fos and p38 mitogen-activated protein kinase activation
    Eugene Lam
    Wound Healing Research Group, Department of Surgery, University of Alberta, Edmonton, AB, Canada
    J Invest Dermatol 125:230-8. 2005
    Previously, we have demonstrated that keratinocyte releasable stratifin, also known as 14-3-3 sigma protein, stimulates matrix metalloproteinase (MMP)-1 expression in dermal fibroblasts...
  2. ncbi Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3
    Vivek Bhalla
    Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0532, USA
    Mol Endocrinol 19:3073-84. 2005
    ..These results demonstrate a novel, physiologically significant role for 14-3-3 proteins in modulating ubiquitin ligase-dependent pathways in the control of epithelial ion transport...
  3. pmc Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3
    Sindhu Rajan
    Institute of Physiology, Marburg University, Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 545:13-26. 2002
    ..Our findings suggest that interaction of 14-3-3 with TASK-1 or TASK-3 may promote the trafficking of the channels to the surface membrane...
  4. doi Cooperative effect of p21Cip1/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF
    P G Hemmati
    Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charite, Campus Berlin Buch, Germany
    Oncogene 27:6707-19. 2008
    ..Furthermore, our data delineate that the disruption of G2/M cell cycle checkpoint control critically determines the sensitivity of the cell toward p14(ARF)-induced mitochondrial apoptosis...
  5. ncbi Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437
    Arun K Rishi
    Veterans Affairs Medical Center, Department of Internal Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    J Biol Chem 278:33422-35. 2003
    ..Identification of CARP-1 as a key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents...
  6. ncbi Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas
    Ekkehard Kunze
    Department of Osteopathology and Haematopathology, University of Gottingen, D 37099 Göttingen, Germany
    Int J Mol Med 18:547-57. 2006
    ....
  7. ncbi Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells
    G L Prasad
    Cell and Molecular Physiology Section, National Cancer Institute, Bethesda, Maryland 20892
    Cell Growth Differ 3:507-13. 1992
    ..HME1 therefore appears to be a cellular differentiation marker that may be down-regulated during neoplastic transformation...
  8. ncbi Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway
    H Leffers
    Institute of Medical Biochemistry, Danish Centre for Human Genome Research, Aarhus University
    J Mol Biol 231:982-98. 1993
    ..masses ranging between 30,000 and 31,100 (isoelectric focussing sample spot proteins 9109 (epithelial marker stratifin), 9124, 9125, 9126 and 9231 in the master two-dimensional gel database of human keratinocyte proteins) that ..
  9. ncbi 14-3-3sigma is a p53-regulated inhibitor of G2/M progression
    H Hermeking
    Johns Hopkins Oncology Center, Baltimore, Maryland, USA
    Mol Cell 1:3-11. 1997
    ..As the fission yeast 14-3-3 homologs rad24 and rad25 mediate similar checkpoint effects, these results document a molecular mechanism for G2/M control that is conserved throughout eukaryotic evolution and regulated in human cells by p53...
  10. ncbi 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
    T A Chan
    The Johns Hopkins Oncology Center, Program in Human Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 401:616-20. 1999
    ..These results may indicate a mechanism for maintaining the G2 checkpoint and preventing mitotic death...
  11. ncbi Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression
    C Laronga
    Departments of Surgical Oncology Molecular and Cellular Oncology and the Breast Cancer Research Program, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 275:23106-12. 2000
    ..These findings define 14-3-3 sigma as a negative regulator of the cell cycle progression and suggest that it has an important function in preventing breast tumor cell growth...
  12. ncbi The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax
    T Samuel
    Laboratory of Molecular Tumor Biology, Department of Dermatology, University of Erlangen Nuremberg, 91052 Erlangen, Germany
    J Biol Chem 276:45201-6. 2001
    ..In conclusion, final sigma not only enforces the p53-dependent G(2) arrest but also delays the apoptotic signal transduction...
  13. ncbi Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth
    Tomohiko Urano
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 417:871-5. 2002
    ..These data provide an insight into the cell-cycle machinery and tumorigenesis of breast cancer by identifying 14-3-3 sigma as a target for proteolysis by Efp, leading to cell proliferation...
  14. ncbi The tumor suppressor gene 14-3-3 sigma is commonly methylated in normal and malignant lymphoid cells
    Kishor Bhatia
    KFNCCC and R, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia, 11211
    Cancer Epidemiol Biomarkers Prev 12:165-9. 2003
    14-3-3 sigma/Stratifin was first identified as an epithelial cell antigen (HME-1) exclusively expressed in epithelia...
  15. pmc 14-3-3 sigma positively regulates p53 and suppresses tumor growth
    Heng Yin Yang
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 23:7096-107. 2003
    ..These results defined an important p53 regulatory loop and suggested that 14-3-3 sigma expression can be considered for therapeutic intervention in cancers...
  16. ncbi 14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid
    Yasuhiro Ito
    Department of Surgery, Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Cancer Lett 200:161-6. 2003
    ..These results suggest that 14-3-3 sigma plays a constitutive role in papillary carcinoma rather than acting as a cell cycle regulator, whereas it is not required for the occurrence and development of follicular tumor...
  17. ncbi Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation
    Jun ichi Akahira
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 10:2687-93. 2004
    ..In this study, we examined the promoter methylation status and expression of 14-3-3 sigma and evaluated its clinical significance in epithelial ovarian cancer...
  18. ncbi Loss of 14-3-3sigma in prostate cancer and its precursors
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Cancer Res 10:3064-8. 2004
    ..The sigma isoform (also called HME-1 or stratifin) is expressed in epithelial cells...
  19. ncbi Keratinocyte-releasable stratifin functions as a potent collagenase-stimulating factor in fibroblasts
    Aziz Ghahary
    Department of Surgery, Wound Healing Research Group, University of Alberta, Edmonton, Alberta, Canada
    J Invest Dermatol 122:1188-97. 2004
    ..peptide mapping, a keratinocyte-derived collagenase-stimulating factor turned out to be a releasable form of stratifin, also known as 14-3-3 sigma protein...
  20. ncbi Immunohistochemical expression of 14-3-3 sigma protein in various histological subtypes of uterine cervical cancers
    Takaaki Sano
    Department of Tumor Pathology, Gunma University, Graduate School of Medicine, Faculty of Medicine, Gunma, Japan
    Pathol Int 54:743-50. 2004
    ..These observations are consistent with the hypothesis that inactivation of either 14-3-3sigma or p16 has an effect equivalent to the expression of E6 and E7 oncoproteins of HPV...
  21. ncbi Prostate cancer is characterized by epigenetic silencing of 14-3-3sigma expression
    Dimitri Lodygin
    Molecular Oncology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried Munich, Germany
    Oncogene 23:9034-41. 2004
    ....
  22. ncbi Differentiated keratinocyte-releasable stratifin (14-3-3 sigma) stimulates MMP-1 expression in dermal fibroblasts
    Aziz Ghahary
    Department of Surgery, Wound Healing Research Group, University of Alberta, Alberta, Canada
    J Invest Dermatol 124:170-7. 2005
    ..identified KDAF as being the keratinocyte-releasable 14-3-3 sigma (14-3-3sigma) protein, which is also known as stratifin. In this study, we hypothesize that differentiated, but not proliferating, keratinocytes are the primary source ..
  23. ncbi A structural basis for 14-3-3sigma functional specificity
    Erik W Wilker
    Center for Cancer Research, Department of Biology and Division of Biological Engineering, Massachsuetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 280:18891-8. 2005
    ....
  24. ncbi 14-3-3sigma expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients
    Alexander Perathoner
    Tyrolean Cancer Research Institute, Innsbruck, Austria
    Clin Cancer Res 11:3274-9. 2005
    ..In this study, we examined the expression of 14-3-3sigma and evaluated its clinical significance in colorectal carcinoma...
  25. pmc Epigenetic regulation of the cell type-specific gene 14-3-3sigma
    Marc M Oshiro
    Pharmacology and Toxicology, University of Arizona, Arizona Cancer Center, Tucson, AZ 85724, USA
    Neoplasia 7:799-808. 2005
    ..These findings extend the spectrum of cell type-specific genes controlled, partly, by normal epigenetic mechanisms, and suggest that this subset of genes may represent important targets of epigenetic dysregulation in human cancer...
  26. ncbi 14-3-3sigma in endometrial cancer--a possible prognostic marker in early-stage cancer
    Kiyoshi Ito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Clin Cancer Res 11:7384-91. 2005
    ..We examined expression of 14-3-3sigma, a regulator of cell proliferation, and evaluated its clinical significance in endometrioid endometrial carcinoma...
  27. ncbi Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma
    Hiroko Nakayama
    Department of Tumor Pathology, Gunma University, Graduate School of Medicine, Faculty of Medicine, Maebashi, Japan
    Pathol Int 55:707-15. 2005
    ....
  28. ncbi Sensitizing hormone-refractory prostate cancer cells to drug treatment by targeting 14-3-3sigma
    Baoguang Han
    Department of Pharmacology and Toxicology, Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mol Cancer Ther 5:903-12. 2006
    ..Based on these studies, we propose that therapeutic intervention targeting 14-3-3sigma may be useful for sensitizing hormone-refractory prostate cancers to chemotherapy by both G2-M checkpoint abrogation and apoptosis enhancement...
  29. ncbi Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factor
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi ken, 980 8575, Japan
    Cancer Sci 98:644-51. 2007
    ..Nuclear cyclin B1-positive breast carcinoma is resistant to adjuvant therapy, and nuclear cyclin B1 immunoreactivity is a potent prognostic factor in breast carcinoma patients...
  30. ncbi 14-3-3sigma controls mitotic translation to facilitate cytokinesis
    Erik W Wilker
    Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 446:329-32. 2007
    ....
  31. ncbi Roles for negative cell regulator 14-3-3sigma in control of MDM2 activities
    H Y Yang
    Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 26:7355-62. 2007
    ..Also, 14-3-3sigma blocks MDM2-mediated retinoblastoma degradation and p53 NEDDylation. Our results provide evidence that 14-3-3sigma is a pivotal MDM2 regulator involved in blocking a variety of activities of MDM2...
  32. ncbi Over-expression of 14-3-3sigma in budding colorectal cancer cells modulates cell migration in the presence of tenascin-C
    Munenori Ide
    Department of General Surgical Science Surgery I, Gunma University Graduate School of Medicine, Gunma 371 8511, Japan
    Oncol Rep 18:1451-6. 2007
    ..001). We concluded that the expression of 14-3-3sigma in the invasive area modulates tumor cell migration in certain types of colorectal cancer and thus facilitates tumor progression...
  33. ncbi Quantitative detection of methylated ESR1 and 14-3-3-sigma gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy
    Joaquina Martínez-Galán
    Servicio de Oncologia Radioterapica, Hospital Virgen de las Nieves, Granada, Spain
    Cancer Biol Ther 7:958-65. 2008
    ..Although numerous issues remain to be resolved, the quantitative measurement of circulating methylated DNA remains a promising tool for cancer risk assessment...
  34. doi Primary human keratinocytes externalize stratifin protein via exosomes
    Claudia Chavez-Munoz
    Department of Surgery, BC Professional Burn and Wound Healing Research Lab, The University of British Columbia, Vancouver, British Columbia, Canada
    J Cell Biochem 104:2165-73. 2008
    Although, stratifin (SFN) is externalized by keratinocytes and stimulates the expression of matrix metalloproteinase-1 (MMP-1) in fibroblasts, its mechanism of externalization is not known...
  35. pmc 14-3-3sigma Modulates pancreatic cancer cell survival and invasiveness
    Divas Neupane
    Department of Medicine and Pharmacology and Toxicology, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Hanover, New Hamsphire 03756, USA
    Clin Cancer Res 14:7614-23. 2008
    ..The purpose of the present study was to investigate the potential role of 14-3-3sigma in pancreatic ductal adenocarcinoma (PDAC)...
  36. doi Inactivation of 14-3-3 sigma by promoter methylation correlates with metastasis in nasopharyngeal carcinoma
    Bin Yi
    Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
    J Cell Biochem 106:858-66. 2009
    ..Our data are the first to show that 14-3-3 sigma is frequently inactivated by promoter methylation in NPC and this aberrant methylation correlates with lymph node and distant metastasis...
  37. doi Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer
    Benjamin Schumacher
    Chemical Genomics Centre of the Max Planck Society, Dortmund, Germany
    FEBS Lett 584:1443-8. 2010
    ..The structure exhibits a potential binding site for small molecules that could stabilize the p53/14-3-3 protein complex suggesting the possibility for therapeutic intervention...
  38. pmc Hypermethylated 14-3-3-sigma and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasis
    Mercedes Zurita
    Radiation Oncology, Hospital Virgen de Nieves, Granada, Spain
    BMC Cancer 10:217. 2010
    ..study was to investigate the association between clinical extension of breast cancer and methylation status of estrogen receptor1 (ESR1) and stratifin (14-3-3-sigma) gene promoters in disease-free and metastatic breast cancer patients.
  39. pmc Role of 14-3-3σ in poor prognosis and in radiation and drug resistance of human pancreatic cancers
    Zhaomin Li
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BMC Cancer 10:598. 2010
    ..Recently, the level of 14-3-3σ mRNA was found to be increased in pancreatic cancers and this increased expression may contribute to the failure in treatment of pancreatic cancers. In the present study, we tested this hypothesis...
  40. pmc 14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis
    Dashnamoorthy Ravi
    Greehey Children s Cancer Research Institute, University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 6:e15864. 2011
    ..To understand better the impact of O₂ on the propagation of cancer cells in vitro, we compared the growth potential of a panel of ovarian cancer cell lines under ambient (21%) or physiological (3%) O₂...
  41. pmc Hypomethylation of the 14-3-3σ promoter leads to increased expression in non-small cell lung cancer
    Vijayababu M Radhakrishnan
    Arizona Cancer Center, 1515 N Campbell Ave, Tucson, Arizona 85724, USA
    Genes Chromosomes Cancer 50:830-6. 2011
    ..And also no mutations were found in 14-3-3σ gene. Overall, our data suggest that misregulated expression of 14-3-3σ gene may be due to altered methylation status. © 2011 Wiley-Liss, Inc...
  42. pmc Aberrant upregulation of 14-3-3ơ expression serves as an inferior prognostic biomarker for gastric cancer
    Wei hua Zhou
    Department of Hematology, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    BMC Cancer 11:397. 2011
    ..However, the expression dynamics of 14-3-3ơ and its clinicopathological/prognostic significance in human tumors are still controversial...
  43. ncbi Immunohistochemical demonstration of 14-3-3 sigma protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineage
    Takashi Nakajima
    Second Department of Pathology and The First Department of Surgery, Gunma University School of Medicine, and Immuno Biological Laboratories Co Ltd, Gunma, Japan
    Pathol Int 53:353-60. 2003
    ....
  44. ncbi Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins
    Romesh R Subramanian
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Cell Res 294:581-91. 2004
    ..These data support a model that 14-3-3 proteins regulate the proapoptotic function of ASK1 in part by controlling its subcellular distribution...
  45. ncbi 14-3-3 proteins--an update
    Paulette Mhawech
    Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cell Res 15:228-36. 2005
    ..Gene silencing of 14-3-3sigma by CpG methylation has been found in many human cancer types. This suggests that therapy-targeting 14-3-3sigma may be beneficial for future cancer treatment...
  46. ncbi Human astrocytes express 14-3-3 sigma in response to oxidative and DNA-damaging stresses
    Jun ichi Satoh
    Department of Bioinformatics and Neuroinformatics, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, Japan
    Neurosci Res 56:61-72. 2006
    ..These observations suggest that 14-3-3sigma might serve as a marker of oxidative and DNA-damaging stresses inducing the mitotic checkpoint dysfunction in reactive astrocytes under pathological conditions...
  47. doi Differential epithelial and stromal protein profiles in keratoconus and normal human corneas
    R Joseph
    Department of Vision Sciences, University of Alabama at Birmingham, 924 18th Street South, Birmingham, AL 35294 4390, USA
    Exp Eye Res 92:282-98. 2011
    ..Additionally, because several epithelial and stromal enzymes exhibited up- or down-regulation in the KC corneas relative to normal corneas, the two layers of KC corneas were under metabolic stress to adjust their remodeling...
  48. doi 14-3-3 sigma and 14-3-3 zeta plays an opposite role in cell growth inhibition mediated by transforming growth factor-beta 1
    Hye Young Hong
    Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, 200 701, Korea
    Mol Cells 29:305-9. 2010
    ..Taken together, our findings indicate that dysregulation of 14-3-3 sigma or 14-3-3 zeta contributes to TGF-beta1 resistance in cancer cells...
  49. pmc Epstein-barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma
    Gyeong Hoon Kang
    Department of Pathology, Seoul NationalUniversity College of Medicine and Cancer Research Institute, Seoul, Korea
    Am J Pathol 160:787-94. 2002
    ..These results demonstrate a relationship between EBV and aberrant methylation in GC and suggest that aberrant methylation may be an important mechanism of EBV-related gastric carcinogenesis...
  50. doi Simulation and assessment of cerebrovascular damage in deep brain stimulation using a stereotactic atlas of vasculature and structure derived from multiple 3- and 7-tesla scans
    Wieslaw L Nowinski
    Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore
    J Neurosurg 113:1234-41. 2010
    ..Therefore, the authors proposed the use of a detailed 3D stereotactic cerebrovascular atlas to assist in SFN planning and to potentially reduce DBS-induced hemorrhage...
  51. ncbi Subcutaneous fat necrosis of the newborn associated with anemia
    B Varan
    Department of Pediatrics, , Ankara, Turkey
    Pediatr Dermatol 16:381-3. 1999
    ..She developed SFN on the fourth postnatal day. Her condition improved after blood transfusions and the skin lesions resolved in 6 weeks. This appears to be the first report of SFN associated with anemia...
  52. doi Epigenetics, spermatogenesis and male infertility
    Singh Rajender
    Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, India
    Mutat Res 727:62-71. 2011
    ..Epigenetic changes, in contrast to genetic aberrations, may be less deleterious because they are potentially reversible. Further research could identify certain drugs capable of reversing epigenetic changes...
  53. ncbi [Expression of iron regulatory protein-2 and ferritins in intestinal mucosa of rats with iron deficiency]
    Wen Li Zuo
    Department of Hematology, Henan Province Cancer Hospital, Zhengzhou 450052, Henan Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:565-8. 2008
    ..05). It is concluded that IRP(2) protein serves as an important regulator of iron metabolism in the human body, and regulates iron uptake from the intestine by controlling the expression of fn mRNA at the post transcriptional level...
  54. doi Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts
    Alessio Papi
    Dipartimento di Biologia Evoluzionistica e Sperimentale, Universita di Bologna, Via Selmi 3, 40126 Bologna, Italy
    J Agric Food Chem 56:875-83. 2008
    ....
  55. pmc Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane
    Olga Azarenko
    Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Carcinogenesis 29:2360-8. 2008
    ....
  56. pmc Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)
    Jonathan B Catterall
    Division of Rheumatology, Department of Medicine, Duke University, Genome Science Research Building I, 905 South LaSalle Street, Durham, NC 27710, USA
    Arthritis Res Ther 12:R229. 2010
    ..In this study, to better understand the early biological changes which occur after acute injury, we investigated synovial fluid and serum biomarkers...
  57. doi Transcriptional regulation and activation of the mitogen-activated protein kinase pathway after Japanese encephalitis virus infection in neuroblastoma cells
    Nimesh Gupta
    Division of Virology, Defence Research and Development Establishment, Gwalior, India
    FEMS Immunol Med Microbiol 62:110-21. 2011
    ..These findings provide a new insight into the role of the mitogen- and stress-activated kinases in JEV pathogenesis and opens up new avenues of therapeutics...
  58. ncbi Molecular characterization of a new ovarian cancer cell line, YDOV-151, established from mucinous cystadenocarcinoma
    HanByoul Cho
    Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    Tohoku J Exp Med 218:129-39. 2009
    ..In addition, the identification and validation of up-regulated genes may provide a genetic approach for identifying biomarkers in ovarian cancer...
  59. doi Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2)
    Taiga Maruichi
    Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Biochem Pharmacol 79:288-95. 2010
    ..These findings clearly demonstrated that human CES1A1 is induced by Nrf2. This is the first study to demonstrate the molecular mechanism of the inducible regulation of human CES1A1...
  60. pmc Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A
    Tomasz A Łeski
    The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    J Bacteriol 187:1815-24. 2005
    ..aureus transpeptidases (PBP2 and PBP4) and an acquired transpeptidase (PBP2A) in staphylococcal cell wall biosynthesis and susceptibility to antimicrobial agents...
  61. pmc Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds
    Hui Nian
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    Environ Mol Mutagen 50:213-21. 2009
    ..Collectively, the results from these studies, and others reviewed herein, provide new insights into the relationships between reversible histone modifications, diet, and cancer chemoprevention...
  62. ncbi The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe
    Maria Castedo
    CNRS UMR 8125, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Oncogene 23:4353-61. 2004
    ..Inhibition of Chk2 thus can sensitize proliferating cells to chemotherapy-induced apoptosis...
  63. ncbi Expression of CXCR-1 and CXCR-2 chemokine receptors on synovial neutrophils in inflammatory arthritides: does persistent or increasing expression of CXCR-2 contribute to the chronic inflammation or erosive changes?
    Salih Pay
    Division of Rheumatology of Department of Medicine, Gulhane Military School of Medicine, Etlik Ankara 06018 Turkey
    Joint Bone Spine 73:691-6. 2006
    ....
  64. doi The antimicrobial effects of glucosinolates and their respective enzymatic hydrolysis products on bacteria isolated from the human intestinal tract
    A Aires
    CITAB UTAD Centre for the Research and Technology for Agro Environment and Biological Sciences, Integrative Biology and Quality group research, Universidade de Tras os Montes e Alto Douro, Apartado, Portugal
    J Appl Microbiol 106:2086-95. 2009
    ..The aim of the study was to evaluate the in vitro antibacterial activity of glucosinolates and their enzymatic hydrolysis product against bacteria isolated from the human intestinal tract...
  65. ncbi Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells
    Changjiang Xu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Oncogene 24:4486-95. 2005
    ....
  66. doi New biomarkers for monitoring the levels of isothiocyanates in humans
    Anoop Kumar
    Department of Environmental Health Sciences, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 2100 SL 29, New Orleans, Louisiana 70112, USA
    Chem Res Toxicol 23:756-65. 2010
    ..This new technique will improve the assessment of ITC exposure and the power of studies on the relationship between ITC intake and cancer...
  67. ncbi DNA damage and expression of checkpoint genes p21(WAF1/CIP1) and 14-3-3 sigma in taurine-deficient cardiomyocytes
    Olga Golubnitschaja
    Department of Radiology, Division of Molecular Experimental Radiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Biochem Pharmacol 66:511-7. 2003
    ..We also carried out quantitative determination of DNA damage...
  68. ncbi The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA
    Cancer Res 67:6409-16. 2007
    ..Because PEITC is a stronger inducer of apoptosis than SFN, these results indicate that direct covalent binding to cellular proteins is an important early event in the induction of apoptosis by the ITCs...
  69. pmc Correlation between CpG methylation profiles and hormone receptor status in breast cancers
    Weiwei Feng
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Breast Cancer Res 9:R57. 2007
    ..The present study was undertaken to determine whether methylation of a set of growth-suppressor genes would correlate to the expression of estrogen receptors (ERs) and progesterone receptors (PRs)...
  70. doi In vitro evidence of nerve growth factor effects on human conjunctival epithelial cell differentiation and mucin gene expression
    Alessandro Lambiase
    CIR Laboratory of Ophthalmology, University Campus Bio Medico, Rome, Italy
    Invest Ophthalmol Vis Sci 50:4622-30. 2009
    ..The aim of this study was to evaluate in vitro the effect of NGF on conjunctival goblet cell differentiation and mucin production and secretion...
  71. doi Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma
    Wen Feng Chu
    Department of Pharmacology, Harbin Medical University, Baojian Road 157, Harbin, Heilongjiang 150081, PR China
    Oral Oncol 45:998-1004. 2009
    ..The present study provides an evidence for testing SFN efficacy in vivo and warranting future investigations to exam the clinical potential of SFN in ACC chemotherapy...
  72. pmc Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression
    Kerstin Gross-Steinmeyer
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Toxicol Sci 116:422-32. 2010
    ..The downregulation of CYP3A4 by SFN may have important implications for drug interactions...
  73. ncbi Differential expression of multiple anti-apoptotic proteins in epidermis of IGF-1 transgenic mice as revealed by 2-dimensional gel electrophoresis/mass spectrometry analysis
    Jianjun Shen
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Mol Carcinog 46:331-40. 2007
    ..The current data suggest that some of the differentially expressed proteins may play a role in the tumor promoting action of IGF-1 in mouse skin...
  74. ncbi Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro
    Gerlinde Pappa
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, C010 2 Chemoprevention, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Carcinogenesis 28:1471-7. 2007
    ..These data stress the need for elucidating mechanistic interactions for better predicting beneficial health effects of bioactive food components...
  75. pmc Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells
    Hyon Jeen Kim
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Allergy Clin Immunol 121:1255-1261.e7. 2008
    ..Recent studies suggest that the redox equilibrium of dendritic cells (DCs) is a key factor in maintaining protective cellular immunity and that a disturbance of this homeostatic mechanism could contribute to immune senescence...
  76. pmc Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry
    Patricia A Egner
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 21:1991-6. 2008
    ..This method determines SFN and all four SFN glutathione-derived metabolites with minimal sample preparation and will be extremely useful in understanding the role of SFN-rich foods in preventing cancer and other chronic diseases...
  77. doi Gene signature of the metastatic potential of cutaneous melanoma: too much for too little?
    Jozsef Timar
    2nd Department of Pathology, Semmelweis University, 1091 Budapest, Hungary
    Clin Exp Metastasis 27:371-87. 2010
    ....
  78. doi Sulforaphane and alpha-lipoic acid upregulate the expression of the pi class of glutathione S-transferase through c-jun and Nrf2 activation
    Chong Kuei Lii
    Department of Nutrition, China Medical University, Taichung 404, Taiwan
    J Nutr 140:885-92. 2010
    ..These results suggest that SFN and LA in either its oxidized or reduced form upregulate the transcription of the GSTP gene by activating c-jun and Nrf2 binding to the enhancer element GPEI...
  79. doi [Small fibre neuropathy: Diagnostic approach and therapeutic issues, and its association with primary Sjögren's syndrome]
    D Sene
    Service de Medecine Interne, Hopital Pitie Salpetriere, AP HP, Universite Paris 6, 75013 Paris, France
    Rev Med Interne 31:677-84. 2010
    ..This requires a better availability of the appropriate diagnostic procedures, the investigation of underlying immunopathological mechanisms and the assessment of the new treatments recently proposed in pSS, mainly rituximab...
  80. ncbi Evaluation of arthropod-borne viruses and other infectious disease pathogens as the causes of febrile illnesses in the Khartoum Province of Sudan
    M C McCarthy
    U S Naval Medical Research Unit No 3, Cairo, Egypt
    J Med Virol 48:141-6. 1996
    ..These data indicated that phleboviruses and to a lesser extent, WN, P. falciparum, and enterobacterial pathogens were causes of acute febrile illnesses following the 1988 flood in Khartoum, Sudan...
  81. ncbi Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
    F L Chung
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, NY 10595, USA
    Carcinogenesis 21:2287-91. 2000
    ..05). The NAC conjugates were inactive as anti-initiators against AOM-induced ACF. These findings provide important laboratory evidence for a potential role of SFN and PEITC in the protection against colon cancer...
  82. ncbi Regulation of the G2/M transition by p53
    W R Taylor
    Department of Molecular Biology, Lerner Research Insititute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Oncogene 20:1803-15. 2001
    ..In summary, multiple overlapping p53-dependent and p53-independent pathways regulate the G2/M transition in response to genotoxic stress...
  83. doi Primary Raynaud phenomenon and small-fiber neuropathy: is there a connection? A pilot neurophysiologic study
    Nisha J Manek
    Mayo Clinic, Rochester, MN 55905, USA
    Rheumatol Int 31:577-85. 2011
    ..The presence of SFN raises the possibility that a subset of patients with primary RP have an underlying, subclinical small-fiber dysfunction. These data open new avenues of research and therapeutics for this common condition...
  84. doi On the relationship between nociceptive evoked potentials and intraepidermal nerve fiber density in painful sensory polyneuropathies
    Jordi Casanova-Molla
    Department of Neurology, Hospital Clinic, Barcelona, Spain
    Pain 152:410-8. 2011
    ..The correlation between nociceptive evoked potentials (laser-evoked potentials and contact heat-evoked potentials) and skin biopsy aids in the diagnosis of painful neuropathies...
  85. ncbi Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes
    C C Conaway
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, One Dana Road, Valhalla, New York 10595, USA
    Chem Res Toxicol 14:1170-6. 2001
    ....
  86. ncbi Single value of serum transferrin receptor is not diagnostic for the absence of iron stores in anaemic patients with rheumatoid arthritis
    S Siebert
    Department of Rheumatology, University Hospital of Wales and University of Wales College of Medicine, Cardiff, UK
    Clin Lab Haematol 25:155-60. 2003
    ....
  87. ncbi Proteomic analysis reveals successive aberrations in protein expression from healthy mucosa to invasive head and neck cancer
    M Roesch-Ely
    Molecular Biology Laboratory, Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany
    Oncogene 26:54-64. 2007
    ..Calgizarrin (S100A11), the Cystein proteinase inhibitor Cystatin A, Acyl-CoA-binding protein, Stratifin (14-3-3 sigma), Histone H4, alpha- and beta-Hemoglobin, a C-terminal fragment of beta-hemoglobin and the alpha-..
  88. pmc Multi-targeted prevention of cancer by sulforaphane
    John D Clarke
    Department of Nutrition and Exercise Sciences, 117 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
    Cancer Lett 269:291-304. 2008
    ..The current status of SFN in human clinical trials also is included, with consideration of the chemistry, metabolism, absorption and factors influencing SFN bioavailability...
  89. doi Clinical and electromyographic deep tendon reflexes in polyneuropathy: diagnostic value and prevalence*
    K R Sharma
    Department of Neurology, University of Miami School of Medicine, FL 33136, USA
    Acta Neurol Scand 119:224-32. 2009
    ..There are few studies that assessed the diagnostic utility of electromyographically recorded DTR (Er-DTR) in patients with polyneuropathy...
  90. ncbi Characterization of gene expression in major types of salivary gland carcinomas with epithelial differentiation
    Ilmo Leivo
    Department of Pathology, Haartman Institute and Helsinki University Central Hospital, P O Box 21 Haartmaninkatu 3, FIN 00014 University of Helsinki, Helsinki, Finland
    Cancer Genet Cytogenet 156:104-13. 2005
    ..The array results were validated by RT-PCR and immunohistochemistry...
  91. ncbi Evaluation of serum transferrin receptor assay in a centralized iron screening service
    S O'Broin
    Department of Haematology, St James s Hospital, Dublin, Ireland
    Clin Lab Haematol 27:190-4. 2005
    ..The high specificity (>90%) of the mean cell haemoglobin for ID may be under-utilized diagnostically...
  92. ncbi The p53 pathway and outcome among patients with T1G3 bladder tumors
    Elena Lopez-Knowles
    Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, and Hospital del Mar, Barcelona, Spain
    Clin Cancer Res 12:6029-36. 2006
    ..The aim was to analyze Tp53 and HDM2 in T1G3 bladder tumors and to determine the prognostic value of their alterations...
  93. ncbi Erythropoiesis and iron metabolism in dominant erythropoietic protoporphyria
    S Alexander Holme
    Department of Dermatology, University Hospital of Wales and School of Medicine, Cardiff University, Cardiff, United Kingdom
    Blood 110:4108-10. 2007
    ..This response may in part be mediated by protoporphyrin, but we found no correlation between erythrocyte protoporphyrin and Hb, sFn, total iron-binding capacity, or transferrin saturation...
  94. ncbi Subcutaneous fat necrosis of the newborn: a review of 11 cases
    A D Burden
    Department of Dermatology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Dermatol 16:384-7. 1999
    ..Hypercalcemia developed in four infants up to 7 weeks after the onset of SFN. Infants with this condition should be carefully monitored for hypercalcemia...
  95. doi Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis
    Mireia Niso-Santano
    Departamento de Bioquimica y Biologia Molecular y Genetica, E U Enfermería y Terapia Ocupacional, Universidad de Extremadura, 10071 Caceres, Spain
    Free Radic Biol Med 48:1370-81. 2010
    ....
  96. pmc Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival
    Vesela P Kovacheva
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    FASEB J 23:1054-63. 2009
    ..DNA methylation within the tumor suppressor gene, stratifin (Sfn, 14-3-3sigma), was proportional to the prenatal choline supply and correlated inversely with the expression ..
  97. ncbi Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C
    Shivendra V Singh
    Department of Pharmacology and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Biol Chem 279:25813-22. 2004
    ..Activation of Chk2 in response to DNA damage is well documented, but the present study is the first published report to link Chk2 activation to cell cycle arrest by an isothiocyanate...
  98. ncbi HFE mutations, iron deficiency and overload in 10,500 blood donors
    H A Jackson
    Department of Haematology, University of Wales College of Medicine and University Hospital of Wales, Cardiff, UK
    Br J Haematol 114:474-84. 2001
    ..The Welsh Blood Service collects blood from about 140 000 people each year including an estimated 950 who are homozygous for HFE C282Y. They are probably healthy and unaware of any family history of iron overload...
  99. ncbi Branching patterns of the common and superficial fibular nerves in fetus
    Zeliha Kurtoglu
    Department of Anatomy, Mersin University, Mersin, Turkey
    Clin Anat 19:621-6. 2006
    ..The reason for different patterns and piercing levels of the nerves may be the effect of the elongating extremity during aging that enforces the fascia and modifies its position with a more stable structure, the nerve...
  100. ncbi Diagnostic role of deep tendon reflex latency measurement in small-fiber neuropathy
    Khema R Sharma
    Department of Neurology, University of Miami School of Medicine, Miami, FL 33136, USA
    J Peripher Nerv Syst 12:223-31. 2007
    ..DTR latency measurement is a reproducible, valuable, sensitive tool in the evaluation of mild subclinical involvement of large fibers...
  101. pmc The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells
    Markus Schwab
    First Department of Medicine ZAFES, Johann Wolfgang Goethe University Frankfurt, Germany
    Immunology 125:241-51. 2008
    ..In this process HBD-2 expression is regulated via VDR, mitogen-activated protein kinase kinase/extracellular-regulated kinase and nuclear factor-kappaB signalling...

Research Grants65

  1. Moving toward Axon Protection and Remyelination Therapies in Man
    Timothy Coetzee; Fiscal Year: 2006
    ..The outcome of the workshop will be published in an appropriate peer-reviewed publication and will also be made available for the scientific community at large. [unreadable] [unreadable] [unreadable]..
  2. ANGIOGENESIS INHIBITORS: A MECHANISM OF ACTION
    Erkki Ruoslahti; Fiscal Year: 2006
    ..This study may provide important information on the mechanism of action of a class of angiogenesis inhibitors, information that may prove helpful in designing clinical trials for these compounds. [unreadable] [unreadable]..
  3. Emily Ho; Fiscal Year: 2014
    ..This application is innovative and timely in bridging basic mechanisms, preclinical models, and human studies of epigenetics and diet. ..
  4. Antioxidants and Antiinflammatory in Colorectal Cancer
    Ah Ng Tony Kong; Fiscal Year: 2012
    ..This is an R01 competing application to study the mechanism of dietary phytochemicals isothiocyanates (sulforaphane and PEITC) and phenolic compounds (curcumin and DBM) alone or in combination against colorectal cancer. ..
  5. Fung Lung Chung; Fiscal Year: 2014
    ..This research will allow design more effective small compounds related to ITCs that target to mutant p53 for cancer prevention and therapy. ..
  6. Isothiocyanates as specific antagonists of human SXR
    David Eaton; Fiscal Year: 2009
    ..Finally, they could help to further elucidate the risks and benefits of sulforaphane, a potential dietary phytochemical that has been proposed as a safe 'nutraceutical'compound to reduce cancer risk. ..
  7. Dietary HDAC Inhibitors in Colon Cancer Prevention
    Roderick H Dashwood; Fiscal Year: 2012
    ....
  8. Richard L Eckert; Fiscal Year: 2016
    ..These studies are highly relevant to understanding the biological role of SFN in preventing skin cancer formation. ..
  9. 7th National Headache Foundation Research Summit
    Rima Dafer; Fiscal Year: 2009
    ....
  10. Louise R Howe; Fiscal Year: 2014
    ..Our proposal is thus highly responsive to several areas of interest defined by PAR-11-079. ..
  11. Fibronectin Binding MSCRAMMs
    AXEL MAGNUS HOOK; Fiscal Year: 2013
    ..Many microorganisms require Fn-binding proteins to be fully infectious. We propose to characterize the microbe-Fn interaction in detail and to determine the molecular basis for the role of Fn-binding proteins in infectious disease. ..
  12. Shivendra Singh; Fiscal Year: 2015
    ..Finally, the possibility that Aim 4 ultimately leads to a novel SFN-based regimen for clinical management of CRPC is equally meritorious. ..
  13. Michelle Hernandez; Fiscal Year: 2014
    ..Angela Kashuba, the director f the clinical pharmacology fellowship at UNC with extensive experience in clinical pharmacokinetic and pharmacodynamic studies. ..
  14. Rodney W Johnson; Fiscal Year: 2015
    ..abstract_text> ..
  15. Yuanyuan Li; Fiscal Year: 2014
    ..Breast cancer affects hundreds of thousands of women world-wide and elucidation of its prevention through natural bioactive products will have global impact. ..
  16. Pilot Clinical &Molecular Analysis of Atypical Nevus Response to Sulforaphane
    JOHN MUNN KIRKWOOD; Fiscal Year: 2013
    ....
  17. Prasun K Datta; Fiscal Year: 2015
    ..abstract_text> ..
  18. Role of 14-3-3 sigma in breast cancer
    Erik Wilker; Fiscal Year: 2006
    ..Biological and biochemical analyses will provide significance to the interactions and modifications discovered. The results from this proposal will identify potential future targets for specific anti-cancer therapies. ..
  19. Cigarette Smoke and Susceptibility to Influenza Infection
    Terry L Noah; Fiscal Year: 2013
    ..abstract_text> ..
  20. Genetic Identification of Sulforaphane's Mechanism of Action in Yeast Cell Death
    NICANOR AUSTRIACO; Fiscal Year: 2010
    ..We expect this research not only to help us better understand the process of cell suicide but also to enhance the drug's efficacy in clinical trials to treat cancer patients. ..
  21. Gwenn A Garden; Fiscal Year: 2015
    ..The program will benefit 250 young neuroscientists at each workshop and countless others via Web-based dissemination activities. ..
  22. Sharmila Shankar; Fiscal Year: 2016
    ..Our studies are very novel and significant because they have prognostic relevance and inhibit pancreatic cancer initiation and progression by targeting CSCs. ..
  23. Survival Skills and Ethics Workshops for Neuroscientists
    Beth A Fischer; Fiscal Year: 2011
    ..Throughout the workshop, special attention will be given to discussions of issues of particular relevance to women, members of under-represented minority groups, and individuals for whom English is a second language. ..
  24. Neuroscience Scholars Program
    Erich D Jarvis; Fiscal Year: 2013
    ..mentoring and networking activities, Scholars will develop increased scientific knowledge and career development skills while building support systems and a shared sense of community critical to managing environmental barriers to ..
  25. CHALKLABS LLC [10-011442]
    X X; Fiscal Year: 2010
    ..The basic grants data plus the results of the topic model analysis will be transferred to Chalklabs, which will integrate it into an interface for Topic Model Browsing and for mapping using the DrL algorithm. ..
  26. MAPPING AND END USER INTERFACE FOR TOPIC MODELS OF NIH GRANTS
    X X; Fiscal Year: 2009
    ..The basic grants data plus the results of the topic model analysis will be transferred to Chalklabs, which will integrate it into an interface for Topic Model Browsing and for mapping using the DrL algorithm. ..
  27. MAPPING AND END USER INTERFACE FOR TOPIC MODELS OF NIH GRANTS
    BRUCE HERR; Fiscal Year: 2011
    ..The basic grants data plus the results of the topic model analysis will be transferred to Chalklabs, which will integrate it into an interface for Topic Model Browsing and for mapping using the DrL algorithm. ..
  28. Yale E Cohen; Fiscal Year: 2016
    ..Consequently, a focused symposium will facilitate and spur growth in this important research area. ..
  29. Protein Kinase G Regulation of Granulosa Cell Viability
    John Peluso; Fiscal Year: 2006
    ..We now propose to test this hypothesis using biochemical, genetic, imaging and cell biological techniques. [unreadable] [unreadable]..
  30. NEOPLASTIC COMPLICATIONS IN INFLAMMATORY BOWEL DISEASE
    Stephen Meltzer; Fiscal Year: 2007
    ..B. Clinical parameters will be correlated with gene expression, methylation and copy number data to delineate specific genes potentially relevant to neoplastic progression in IBD. ..
  31. Commercializing digital wireless telemetry: the animal epilepsy monitoring unit
    Andre Fenton; Fiscal Year: 2009
    ....
  32. Intestinal Disposition of Chemoprevention Agents
    Thomas Cook; Fiscal Year: 2004
    ..abstract_text> ..
  33. Neurobiology of Disease -- Teaching Workshop
    Arnold Kriegstein; Fiscal Year: 2005
    ..Society members are encouraged to suggest topics in the SFN Newsletter. ..
  34. TUMOR CELLS IN CIRCULATION
    Erkki Ruoslahti; Fiscal Year: 2001
    ..Finally, the ability to eliminate tumor cells from the circulation by sFN administration may provide additional protection against tumor cell transfer in bone marrow transplantation used to treat cancer and against tumor metastasis. ..
  35. Structure and Function: Diabetic Small Fiber Neuropathy
    Christopher Gibbons; Fiscal Year: 2006
    ..The proposed studies will elucidate these structure-function relationships in patients with diabetic SFN. [unreadable] [unreadable]..
  36. SCHLAFEN--THE CONTROL OF THYMOCYTE GROWTH & DEVELOPMENT
    STEPHEN HEDRICK; Fiscal Year: 1999
    ..Upon identifying a specific point in cell cycle arrest, we will begin to determine the molecular target of Sfn. Experiments will focus on the Cyclin holoenzymes that are known to regulate specific checkpoints in the cell cycle. ..
  37. Novel Methylation Targets in Gastric Cancer
    Stephen Meltzer; Fiscal Year: 2005
    ..3) To correlate the results of, aims (1) and (2) with each other as well as with other clinical and biologic parameters of these gastric lesions. ..
  38. New Anti-Metastatic and Anti-Angiogenic Compounds
    Erkki Ruoslahti; Fiscal Year: 2001
    ..proposed commercial application: not available ..
  39. SUPERFIBRONECTIN--A NEW ANTIMETASTATIC AGENT
    Renata Pasqualini; Fiscal Year: 1999
    ..These studies are expected to provide the information needed to proceed into experimental clinical trials after the phase II of this grant. PROPOSED COMMERCIAL APPLICATION: Not available. ..
  40. SURVIVAL SKILLS AND ETHICS WORKSHOP FOR NEUROSCIENTISTS
    Beth Fischer; Fiscal Year: 2002
    ..Some of the faculty will be drawn from the local areas at which the workshops will be held. ..
  41. Ontogeny of Motor Systems: Neurogenesis to Behavior
    Ronald Oppenheim; Fiscal Year: 2003
    ..g., by using the membership mailing list to the Association for Ethnic Diversity in the Neurosciences). ..
  42. Reduction of Amyloid Burden by Antisense APP
    Neelima Chauhan; Fiscal Year: 2005
    ..Significance: Targeting the translation of amyloidogenic APP by antisense synthetic oligodeoxynucleotides may prove to be an effective and safe form of gene therapy for treating familial AD and other genetic diseases. ..
  43. Survival Skills and Ethics Workshops for Neuroscientists
    Beth Fischer; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  44. Bioactive Food Comoponents, Alternative Medicine and Cancer Chemoprevention: Rece
    Shivendra Singh; Fiscal Year: 2007
    ..The theme of our symposium is highly focused and attracts leaders and highly accomplished scientists to discuss promises and challenges in cancer chemoprevention research. [unreadable] [unreadable] [unreadable] [unreadable]..
  45. Control of hTERT in initiation and progression of aging
    Trygve Tollefsbol; Fiscal Year: 2002
    ..These studies are intended to strengthen the potential for development of therapeutic control of hTERT expression during aging and in age-associated diseases such as cancer. ..
  46. Epigenetics of Dietary EGCG in Cancer Prevention
    Trygve Tollefsbol; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  47. MECHANISM OF DRUG BINDING TO P-GLYCOPROTEIN
    Jian Ting Zhang; Fiscal Year: 2001
    ..This work may lead us to the discovery of a new family of chaperone proteins associated with ribosomes that are important in determining the folding of membrane proteins co-translationally. ..
  48. Role of p170 in lung tumorigenesis
    Jian Ting Zhang; Fiscal Year: 2007
    ..This work will certainly add to our understanding of the functional mechanism of translation initiation of protein synthesis. ..
  49. Toxicological Relevance of Human GST P1-1 Polymorphism
    Shivendra Singh; Fiscal Year: 2005
    ..abstract_text> ..
  50. MOLECULAR BASES OF MULTIDRUG RESISTANCE IN CANCERS
    Jian Ting Zhang; Fiscal Year: 2001
    ..Additionally, this study will increase our understanding of how specific protein topological structures are related to transport functions in general. ..
  51. Orphan nuclear receptor TLX signaling in neural stem cells
    Yanhong Shi; Fiscal Year: 2010
    ..Each component of the TLX signaling network, either downstream target genes or upstream regulators, will be novel molecular targets for intervening neurodegenerative diseases. ..
  52. ROLE OF HUMAN GST PI POLYMORPHISM IN DRUG RESISTANCE
    Shivendra Singh; Fiscal Year: 2003
    ..These studies, in the long term, may be valuable in identifying subjects that may be at a higher risk for developing GST-mediated resistance to some alkylating agents. ..
  53. MECHANISM OF ANTICARCINOGENIC ACTIVITY--ORGANOSULFIDES
    Shivendra Singh; Fiscal Year: 2003
    ..Insights gained from these studies should help in devising practical dietary recommendation for humans. ..
  54. NOVEL GST AND DETOXICATION OF DIOL EPOXIDES
    Shivendra Singh; Fiscal Year: 2006
    ..In the long-term, this knowledge will guide us in developing strategies for prevention of PAH-induced cancers in humans. ..
  55. THE UCLA CLINICAL NUTRITION RESEARCH UNIT
    David Heber; Fiscal Year: 2006
    ..The UCLA CNRU is serving as a regional and national resource at the cutting edge of nutrition and cancer prevention research...
  56. Knockout/congenic strains to map and identify QTL's
    Bruce Herron; Fiscal Year: 2007
    ..Subcongenic strains will be made for further refinement of the region and to be used as future tools for the eventual positional cloning of these genes. [unreadable] [unreadable]..
  57. TLX Ligands in Neural Stem Cells & Neurodegeneration
    Yanhong Shi; Fiscal Year: 2007
    ..Thus, these studies are directly responsive to the NINDS Collaborative Research in Stem Cell Biology. [unreadable] [unreadable] [unreadable]..
  58. UCLA TRAINING PROGRAM IN NUTRITION AND OBESITY
    David Heber; Fiscal Year: 2007
    ..abstract_text> ..
  59. MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLIN
    Roderick Dashwood; Fiscal Year: 2008
    ..3C. Determine CHL effects on beta-catenin nuclear export and Adherins junction remodeling. 3D. Assess direct effects of CHL on a downstream target of beta-catenin, c-Jun. ..
  60. Targeting the oligomerization of human ABCG2
    Jian Ting Zhang; Fiscal Year: 2009
    ..This work may also lead us to the discovery of a new class of therapeutic agents that can help overcome drug-resistant cancers. ..
  61. GENETICS OF VEGF MEDIATED ANGIOGENESIS IN MOUSE SKIN
    Bruce J Herron; Fiscal Year: 2010
    ..Our results will improve the validity of testing of mouse models and could lead to the discovery of new therapeutic targets or biomarkers for VEGF mediated therapies. ..
  62. Regulation and role of CEACAM6 in the lung alveolus
    Philip L Ballard; Fiscal Year: 2011
    ..The studies of this project will examine expression and function of the protein in normal lung and its role in response to lung injury and infection. ..
  63. Regulation of cyclin-dependent kinase inhibitor p27 in cancer
    Mong Hong Lee; Fiscal Year: 2008
    ..abstract_text> ..
  64. Mechanisms of Chemoprevention by Resveratrol
    Rakesh Srivastava; Fiscal Year: 2009
    ..Thus, resveratrol based strategies can be utilized for prevention and treatment of prostate cancer, and in the long-term it may have profound impact on the overall incidence of human prostate cancer. ..